CN114452343A

CN114452343A - Plant extract eyesight improving liquid and preparation method thereof

Info

Publication number: CN114452343A
Application number: CN202111455743.4A
Authority: CN
Inventors: 刘溪金; 刘强
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-12-02
Filing date: 2021-12-02
Publication date: 2022-05-10
Anticipated expiration: 2041-12-02
Also published as: CN114452343B

Abstract

The invention relates to A61, in particular to a plant extract eyesight improving liquid and a preparation method thereof. The raw materials for preparing the eyesight improving solution comprise, by weight, 5-10% of wild chrysanthemum flower extract, 1-4% of rhizoma acori graminei extract and 1-2% of semen cassiae extract. The invention provides an eyesight improving liquid, which can fully exert the effects of improving eyesight, diminishing inflammation, relieving eye swelling and pain and the like by using a wild chrysanthemum extract as a monarch drug and adding various components such as a grassleaf sweelflag rhizome extract, a cassia seed extract and the like. The components of the plant extracts are different, partial substances are separated out after the plant extracts are mixed with water, particularly in the process of gradually reducing the temperature, and the problems of separation and the like can be effectively reduced and the eyesight improving liquid is promoted to keep clear and transparent by adding the radix ophiopogonis extracting solution, the medlar extracting solution, the liquorice extracting solution and the like.

Description

Plant extract eyesight improving liquid and preparation method thereof

Technical Field

The invention relates to A61, in particular to a plant extract eyesight improving liquid and a preparation method thereof.

Background

The eyes are the most important parts of the human body, are the windows of soul, are glittering and translucent, are clear and bright like autumn water, and are the same appearance of the eyes of the person, which is also pursued by the person. However, with the progress of times and scientific development, the living standard of people is improved, and electronic products such as televisions, projectors, computers, panels, mobile phones and the like appear endlessly and are popularized in various families and hands, so that children can read books without leaving the mobile phone panels at present. Tremble sound, fast hand, believe a little, it is everywhere to elude, the time that occupies everybody is not had a hole, it is the normality to stay up to play the cell-phone flat board night, it is inevitable to use eyes excessively, it is unserviced to follow it is eyes, tired eye, dry eye, blurred vision, blepharospasm, dark eye ring, eyelid edema, eye bag, eyes congestion etc. eye problem become the symptoms that daily everybody faces also must be solved in time.

Pure traditional Chinese medicine formula is mild, effective and non-irritant eyesight improving liquid, multiple effective components reach the whole eyes through a skin penetration mode, eye nutrition can be quickly supplemented, the immunity and the oxidation resistance of the eyes are improved, the metabolism of eye tissues is promoted, the blood circulation of the eyes is improved, and the elasticity of the eyes is recovered, so that … … effects of improving eyesight, removing nebula, clearing heat, relieving spasm, removing dark circles, promoting blood circulation, removing blood stasis and the like are achieved, for example, CN107496642A discloses blood activating and eyesight improving liquid which comprises fructus viticis, mustard, tribulus terrestris, folium mori, cortex fraxini, cortex phellodendri and other substances.

However, the components in the existing eyesight improving liquid are complex, the use safety is difficult to ensure, and suspended matters and the like also appear in the storage process, so that the eyesight improving liquid is difficult to use for a long time once opened.

Disclosure of Invention

In order to solve the above problems, the first aspect of the present invention provides a plant extract eyesight improving solution, wherein the eyesight improving solution is prepared from, by weight, 5-10% of a wild chrysanthemum flower extract, 1-4% of a grassleaf sweelflag rhizome extract, 1-2% of a cassia seed extract, 1-4% of a red ginseng extract, 1-4% of a safflower extract, 1-5% of a glossy privet fruit extract, and the balance water.

As a preferred technical scheme of the invention, the eyesight improving solution also comprises 1-2% of radix ophiopogonis extract, 1-3% of medlar extract and 1-4% of gardenia extract by weight.

As a preferable technical scheme of the invention, the preparation raw materials of the eyesight improving solution further comprise 1-3% of polygala tenuifolia extract, 1-4% of liquorice extract and 1-4% of phellodendron extract in percentage by weight.

As a preferred technical scheme, the eyesight improving solution also comprises 1-2% of poria cocos wolf extract, 1-2% of salvia miltiorrhiza extract and 1-2% of costustoot extract by weight.

As a preferable technical scheme, the eyesight improving solution also comprises 1-2% of semen plantaginis extract and 1-3% of gentian extract by weight.

As a preferable technical scheme, the eyesight improving solution also comprises 1-3% of agilawood extracting solution and 1-3% of wormwood extracting solution in percentage by weight.

As a preferred technical scheme of the invention, the preparation raw materials of the eyesight improving solution further comprise 1-2% of cistanche extract and 1-5% of schisandra extract in percentage by weight.

As a preferred technical scheme, the eyesight improving liquid also comprises 1-2% of fructus forsythiae extract and 1-2% of pepper extract according to weight percentage.

Flos Chrysanthemi Indici is a perennial herb of Compositae, and has effects of dispelling pathogenic wind and heat, and relieving swelling and removing toxic substance. Contains volatile oil, flos Chrysanthemi Indici lactone, flos Buddlejae glycoside, flos Chrysanthemi Indici alcohol, and flos Chrysanthemi Indici triol (Chrysanthemum heterotriol). Acorus gramineus belonging to genus Acorus, contains beta-asarone, cis-methyl isoeugenol, elemene, asarone, delta-piper jejunum, thymol, and carnosic acid. Semen Cassiae is dry mature seed of Cassia tora or Cassia tora L.of Leguminosae, and can be used for treating conjunctival congestion, pain, photophobia, lacrimation, dim and unclear vision, etc. Ginseng radix Rubri is a perennial herb of Panax of Araliaceae, and contains triterpene saponin, volatile oil, polysaccharide, amino acid, etc. Fructus Ligustri Lucidi is fruit of Ligustrum lucidum belonging to Oleaceae. Carthami flos, Compositae plant of Campanulales, contains chlorogenic acid, caffeic acid, and Carthami flos polysaccharide which is prepared by linking glucose, xylose, arabinose and galactose (galactose) with beta-chain. Radix Ophiopogonis, a perennial evergreen herb of Ophiopogon of Liliaceae, contains ophiopogonin, glucose, amino acids, steroid saponins, sitosterol, alkaloids, etc., and has effects of relieving fatigue and scavenging free radicals. Fructus Lycii, belonging to genus Lycium of family Solanaceae, contains Lycium barbarum polysaccharides, betaine, atropine, and henbane, and has mild nature and sweet taste. Gardenia jasminoides ellis is fruit of Gardenia jasminoides Ellis of Rubiaceae, and has effects of purging pathogenic fire, relieving restlessness, clearing heat and promoting diuresis. Polygala tenuifolia belonging to genus Polygala of family Polygalaceae contains tenuifolin, oroxanthone, oligosaccharide ester and alkaloid, and has effects of tranquilizing mind, improving intelligence, and relieving swelling. Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch of Leguminosae, contains glycyrrhizic acid and liquiritin, and has effects of clearing away heat and toxic materials, and relieving spasm and pain. Cortex Phellodendri is dry bark of phellodendron amurense belonging to Rutaceae, and has effects of clearing heat and eliminating dampness. The invention can fully exert the eyesight improving effect by controlling the composition and the dosage of raw materials, and can promote the dispersion of insoluble oily components while increasing the viscosity of the eyesight improving solution and acting with substances such as small molecular alcohol or alkali, thereby avoiding the increase of the turbidity of the eyesight improving solution caused by aggregation and obtaining the eyesight improving solution with higher compatibility and clarity and transparency.

In addition, the invention adopts natural plant sources, is safe and nontoxic, can contact human mucosa and does not have any stimulation or anaphylactic reaction to human bodies, can resist various bacteria, fungi, viruses, parasites and other microorganisms, and can realize zero addition of preservatives. The zanthoxylum bungeanum fruit extract contains active ingredients such as limonene, cumic alcohol, dinosaur alcohol, phytosterol, benzoic acid, unsaturated organic acid, diosmetin, alkaloid and the like, and the active ingredients can easily permeate a cell membrane structure to interfere the permeability of a microbial cell membrane, hinder the absorption of the cell membrane on amino acid and disorder the physiological activity of microbes, so that the effect of bacteriostasis is achieved. The fructus forsythiae extract contains hypericin, triterpenoid saponin, phytosterol, forsythol, alkaloid, saponin, oleanolic acid, coumarins, abundant vitamins, and small amount of volatile oil. They penetrate the cell body through the cell membrane to denature proteins, thereby exerting antibacterial effects. Hypericin has broad-spectrum antibacterial effect, has strong inhibiting effect on Staphylococcus aureus and Shigella dysenteriae, and has inhibiting effect on typhoid bacillus, Vibrio cholerae, Escherichia coli, Pseudomonas aeruginosa, Bordetella pertussis, Mycobacterium tuberculosis, Diplococcus pneumoniae, and hemolytic streptococcus, and also has inhibiting effect on influenza virus.

As a preferable technical scheme, the preparation raw material of the eyesight improving solution is prepared by distillation extraction or supercritical extraction. Various extracts in the eyesight improving solution provided by the invention are extracted by a water distillation extraction or supercritical extraction method well known in the art and are obtained after filtration, wherein the weight ratio of each plant to water in the extraction process is 1: 0.8 to 1.2.

The second aspect of the invention provides a preparation method of the plant extract eyesight improving liquid, which comprises the following steps: mixing the raw materials for preparing the eyesight improving solution to obtain the eyesight improving solution.

Compared with the prior art, the invention has the following beneficial effects:

(1) the invention provides an eyesight improving liquid, which can fully exert the effects of improving eyesight, diminishing inflammation, relieving eye swelling and pain and the like by using a wild chrysanthemum flower extract as a monarch drug and adding various components such as a grassleaf sweelflag rhizome extract, a cassia seed extract, a red ginseng extract, a safflower extract, a glossy privet fruit extract and the like as auxiliary materials.

(2) The preparation method is simple through simple water distillation extraction or supercritical extraction, and the inventor finds that partial substances are separated out after the plant extracts are different in components and are mixed by adding water, particularly in the process of gradually reducing the temperature, and the problems of separation and the like can be effectively reduced by adding the radix ophiopogonis extracting solution, the medlar extracting solution, the liquorice extracting solution and the like, so that the eyesight improving solution is kept clear and transparent.

(3) In addition, the taste of the components of the eyesight improving liquid is different, even conflicts with the wild chrysanthemum extract, and the taste is influenced when the eyesight improving liquid is used, and the poria cocos, the red sage root extract, the costustoot extract and the like are added, so that the eyesight improving liquid can improve the eyesight improving effect, improve the smell of the eyesight improving liquid and reduce the irritation.

(4) In order to improve the storage time of the existing eyesight improving liquid, chemical preservative components are generally added to reduce the problems of bacterial breeding and the like after the eyesight improving liquid is opened, but the eyesight improving liquid is not beneficial to acting on eyes.

(5) The invention adopts the compounding of various plant extracts, the obtained eyesight improving liquid is clear and transparent, has stable pH and stability, does not generate precipitate and the like when being subjected to the effects of centrifugation and the like, and can quickly play the role of improving eyesight.

Drawings

FIG. 1 shows the results of measurement of skin blood flow.

FIG. 2 shows the measurement of the water content of stratum corneum.

FIG. 3 shows the results of skin texture measurements of a subject.

Fig. 4 is a skin texture measurement result of another subject.

Detailed Description

Examples

The raw materials used in the examples are all prepared by a method of water distillation extraction, and the specific preparation method comprises the steps of crushing plants, adding the raw materials in a weight ratio of 1: 1, distilling and extracting for 1-2 h, and filtering (a 2000-mesh screen) to obtain the plant extract.

Example 1

The embodiment provides a plant extract eyesight improving solution, which is prepared from, by weight, 10% of a wild chrysanthemum flower extract, 4% of a grassleaf sweelflag rhizome extract, 2% of a cassia seed extract, 4% of a red ginseng extract, 4% of a safflower extract, 5% of a glossy privet fruit extract, the balance of water, 2% of a dwarf lilyturf tuber extract, 3% of a Chinese wolfberry fruit extract, 4% of a gardenia extract, 3% of a polygala tenuifolia extract, 4% of a licorice extract, 4% of a phellodendron bark extract, 2% of a poria cocos extract, 2% of a salvia miltiorrhiza extract, 2% of an elecampane extract, 2% of a plantain seed extract, 3% of a gentian extract, 3% of an agilawood extract, 3% of a blumea extract, 2% of cistanche deserticola extract, 5% of a schisandra chinensis extract, 2% of a forsythia fruit extract, and 2% of a zanthoxylum bunge fruit extract.

The present invention also provides a method for preparing the plant extract eyesight improving solution, comprising: mixing the raw materials for preparing the eyesight improving solution to obtain the eyesight improving solution.

Example 2

The embodiment provides a plant extract eyesight improving solution, which is prepared from, by weight, 5% of a wild chrysanthemum flower extract, 1% of a rhizoma acori graminei extract, 1% of a semen cassiae extract, 1% of a red ginseng extract, 1% of a red flower extract, 1% of a glossy privet fruit extract, the balance of water, 1% of a radix ophiopogonis extract, 1% of a medlar extract, 1% of a gardenia extract, 1% of a polygala tenuifolia extract, 1% of a licorice extract, 1% of a phellodendron extract, 1% of a poria cocos extract, 1% of a salvia miltiorrhiza extract, 1% of a costustoot extract, 1% of a plantain seed extract, 1% of a gentian extract, 1% of an agilawood extract, 1% of a blumea extract, 1% of a cistanche extract, 1% of a fructus schizandrae extract and 1% of a pepper extract.

Example 3

The embodiment provides a plant extract eyesight improving solution, which is prepared from, by weight, 10% of a wild chrysanthemum flower extract, 4% of a rhizoma acori graminei extract, 2% of a semen cassiae extract, 4% of a red ginseng extract, 4% of a safflower extract, 5% of a fructus ligustri lucidi extract, the balance of water, 4% of a fructus gardeniae extract, 3% of a polygala tenuifolia extract, 4% of a cortex phellodendri extract, 2% of a poria cocos extract, 2% of a salvia miltiorrhiza extract, 2% of an elecampane extract, 2% of a semen plantaginis extract, 3% of a radix gentianae extract, 3% of an agilawood extract, 3% of an wormwood extract, 2% of a cistanche salsa extract, 5% of a fructus schizandrae extract, 2% of a forsythia extract and 2% of a pepper extract.

Example 4

The embodiment provides a plant extract eyesight improving solution, which is prepared from, by weight, 10% of a wild chrysanthemum flower extract, 4% of a grassleaf sweelflag rhizome extract, 2% of a cassia seed extract, 4% of a red ginseng extract, 4% of a safflower extract, 5% of a glossy privet fruit extract, the balance of water, 2% of a dwarf lilyturf tuber extract, 3% of a Chinese wolfberry fruit extract, 4% of a gardenia extract, 3% of a polygala tenuifolia extract, 4% of a licorice extract, 4% of a phellodendron bark extract, 2% of a poria cocos extract, 2% of a salvia miltiorrhiza extract, 2% of an elecampane extract, 2% of a plantain seed extract, 3% of a gentian extract, 3% of an agilawood extract and 3% of a wormwood extract.

Evaluation of Performance

1. Measurement of skin blood flow: the effect of the ocular fluid provided in example 1 on blood flow to the eye and nutrient delivery were monitored by measuring Skin Blood Flow (SBF). Changes in skin blood flow in the area using the ocular fluid are measured by a laser doppler hemometer (laser doppler can monitor the amount of blood perfusion throughout the microcirculatory system, including capillaries (nutrient blood flow), arterioles, venules, and anastomotic branches).

Test subjects: the subjects were 15 healthy adults, 6 males and 9 females, aged 20-25 years.

The test method comprises the following steps: the blood flow change before the eye is improved by using the laser center of a laser Doppler blood flow instrument to measure the skin around the eye. The 5 minute measurement was made and the blood flow values for the first and fifth minutes were recorded. After applying the eye brightening solution to the skin around the eyes, the blood flow changes were measured and recorded for analysis at 2, five, 10 and 15 minutes, respectively, and the results are shown in fig. 1.

And (4) test conclusion: the blood flow change of the skin is not very different from 1min to 5min before the eyesight improving liquid is used, and the blood flow is obviously increased after the eyesight improving liquid is used for 2 min.

2. Measuring the water content of the skin stratum corneum: SKICON-200 is adopted to measure the skin conductance to measure the water content of the stratum corneum of the skin so as to reflect the change of the number of fine lines of the skin and the improvement of the elasticity of the skin.

Test subjects: 20 healthy subjects, age 19-55 years, mean not 34 years old, were randomly divided into two groups, one group did not use the eyesight improving solution, and the other group used the eyesight improving solution provided in example 1, and subjects applied the eyesight improving solution once every morning and evening, and required the product to be applied evenly, during which no other skin care product was applied.

The test method comprises the following steps: the water content of the stratum corneum of the skin was measured at 0, 2, 4 and 8 weeks of the test, and the test subjects were asked to evaluate the state and the supervisor. The environmental temperature is required to be about 20-25 ℃ and the relative humidity is required to be 40-50% during testing, and a subject cleans the skin around the eyes to wait for testing during measurement.

Measuring the water content of the horny layer: the SKICON-200 high-frequency conductance tester is used for indirectly measuring the water content of the epidermis by detecting the conductivity of the skin to the high-frequency current of 3.5 MHz. The conductance method and the measured stratum corneum moisture content correlation coefficient can be up to 0.99, the moisture content of the stratum corneum can be measured very sensitively, the pouch positions are measured continuously for 7 times around the eyes, and the average value is obtained after the maximum value and the minimum value are removed, and the result is shown in figure 2.

And (4) test conclusion: the water content of the horny layer of the skin is reduced in 0 to 8 weeks before the eyesight improving solution is not used, and the water content is obviously increased in 2 weeks after the eyesight improving solution is used.

3. Skin texture determination: subjective skin texture assessment was performed by clinical scoring. The method comprises the following steps: 1. the skin condition around the eyes was used as a criterion for judging the aging characteristics of the skin, and the skin aging condition was graded according to the skin wrinkles and skin condition. 2. Female volunteers of 25-45 years old were randomly selected. 3. The subjects were washed and kept in a constant temperature and humidity environment at a temperature of about 22 ℃ and a humidity of 50% for 20min, and the same parts around their eyes were photographed. 4. The subjects apply the eyesight improving liquid once every morning and evening, the product is required to be uniformly applied, no other skin care products are applied in the period, and the service cycle is 4 weeks. 5. After four weeks, the anti-aging and anti-wrinkle effects of the eyesight improving solution are judged by comparing the front and rear pictures, and the results are shown in fig. 3 and 4, and it is found that the eyesight improving solution provided by the embodiment 1 of the invention can effectively reduce wrinkles around eyes and promote fine skin texture.

4. Cooling stability: the eyesight improving solution provided by the embodiment is cooled to 5 ℃ from 60 ℃, the cooling rate is 1 ℃/min, whether the problems of precipitation or solution transparency reduction exist or not is observed, and the results show that the precipitation does not exist or the transparency is reduced in the embodiments 1-2, and the transparency is reduced in the embodiment 3.

5. Breeding of microorganisms: the eyesight improving solutions provided in examples 1-2 were allowed to stand at room temperature for 15 days, and turbidity changes before and after standing were observed to be less than 0.02, while turbidity changes in example 4 were 0.08.

According to the test results, the eyesight improving liquid provided by the invention has good eyesight improving, relieving and anti-inflammatory effects.

Claims

1. The plant extract eyesight improving liquid is characterized by being prepared from 5-10 wt% of wild chrysanthemum flower extracting solution, 1-4 wt% of rhizoma acori graminei extracting solution, 1-2 wt% of semen cassiae extracting solution, 1-4 wt% of red ginseng extracting solution, 1-4 wt% of safflower extracting solution, 1-5 wt% of glossy privet fruit extracting solution and the balance of water.

2. The plant extract eyesight improving solution according to claim 1, wherein the eyesight improving solution is prepared from, by weight, 1-2% of an radix ophiopogonis extract, 1-3% of a medlar extract and 1-4% of a gardenia extract.

3. The plant extract eyesight improving solution according to claim 1, wherein the eyesight improving solution is prepared from raw materials including, by weight, 1-3% of polygala tenuifolia extract, 1-4% of licorice extract, and 1-4% of phellodendron extract.

4. The plant extract eyesight improving solution according to claim 1, wherein the raw materials for preparing the eyesight improving solution further comprise, by weight, 1-2% of poria cocos wolf extract, 1-2% of salvia miltiorrhiza extract and 1-2% of elecampane extract.

5. The plant extract eyesight improving solution according to claim 1, wherein the eyesight improving solution is prepared from raw materials including, by weight, 1-2% of semen plantaginis extract and 1-3% of radix gentianae extract.

6. The plant extract eyesight improving solution according to claim 1, wherein the eyesight improving solution is prepared from raw materials including, by weight, 1-3% of agilawood extract and 1-3% of wormwood extract.

7. The plant extract eyesight improving solution according to claim 1, wherein the raw materials for preparing the eyesight improving solution further comprise, by weight, 1-2% of a cistanche extract and 1-5% of a schisandra extract.

8. The plant extract eyesight improving solution according to claim 1, wherein the eyesight improving solution is prepared from 1-2% by weight of fructus forsythiae extract and 1-2% by weight of fructus Zanthoxyli extract.

9. The plant extract eyesight improving solution according to any one of claims 1 to 8, wherein the raw materials for preparing the eyesight improving solution are prepared by distillation extraction or supercritical extraction.

10. A method for preparing the plant extract eyesight improving solution according to any one of claims 1 to 9, comprising: mixing the raw materials for preparing the eyesight improving solution to obtain the eyesight improving solution.