CN114452343B

CN114452343B - Plant extract for reducing periocular wrinkles and preparation method thereof

Info

Publication number: CN114452343B
Application number: CN202111455743.4A
Authority: CN
Inventors: 刘溪金; 刘强
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-12-02
Filing date: 2021-12-02
Publication date: 2023-06-23
Anticipated expiration: 2041-12-02
Also published as: CN114452343A

Abstract

The invention relates to A61, in particular to a plant extract eyesight improving liquid and a preparation method thereof. The preparation raw materials of the eyesight improving liquid comprise, by weight, 5-10% of wild chrysanthemum flower extract, 1-4% of grassleaf sweelflag rhizome extract and 1-2% of cassia seed extract. The invention provides an eyesight improving liquid, which can fully play roles of improving eyesight, diminishing inflammation, relieving swelling and pain of eyes and the like by using wild chrysanthemum extract as a monarch drug and assisting with a plurality of components such as grassleaf sweelflag rhizome extract, cassia seed extract and the like, and the eyesight improving liquid provided by the invention can not stimulate eyes and has mild effect. The plant extracts have different components, and after being mixed with water, partial substances are separated out, especially when the temperature is gradually reduced.

Description

Plant extract for reducing periocular wrinkles and preparation method thereof

Technical Field

The invention relates to A61, in particular to a plant extract eyesight improving liquid and a preparation method thereof.

Background

The eyes are very important parts of the human body, are heart windows, are crystal clear, have bright eyes like autumn water, clear and bright patterns of the eyes of the human body, and are also pursued by the human body. However, with the progress of the times, the scientific development is advanced, and electronic products such as televisions, projectors, computers, tablets and mobile phones are endlessly appeared and popularized in various families and every person, so that the children can not read books from the mobile phone tablet at present. Tremble, fast hand, weChat, panned precious everywhere, no hole is left in the time of taking everyone, the mobile phone tablet is always played at night, the excessive use of eyes is inevitable, and the eye problems such as eye fatigue, dry eyes, blurred vision, blepharospasm, dark eye circles, eyelid edema, eye bags, eye congestion and the like become symptoms which are required to be solved in time even if people face daily.

The pure traditional Chinese medicine formula is mild, effective and non-irritating, and the eye-improving liquid can make various effective components reach the whole eyes in a skin permeation mode, can quickly supplement eye nutrition, improve eye immunity and antioxidation capability, promote eye tissue metabolism, improve eye blood circulation, and enable eyes to recover elasticity, thereby achieving the effects of … … improving eyesight and removing nebula, clearing heat and relieving spasm, removing black eye, promoting blood circulation and removing blood stasis, and the like, and as CN107496642A discloses a blood-activating eye-improving liquid which comprises materials such as fructus viticis, radix et rhizoma Sinapis Albae, fructus tribuli, folium mori, cortex fraxini, cortex phellodendri, and the like.

However, the components in the prior eyesight improving liquid are complex, so that the use safety is difficult to ensure, and suspended matters and the like appear in the storage process, so that once the eyesight improving liquid is opened, the eyesight improving liquid is difficult to use for a long time.

Disclosure of Invention

In order to solve the problems, the first aspect of the invention provides a plant extract eyesight improving liquid, which is prepared from the following raw materials, by weight, 5-10% of wild chrysanthemum flower extract, 1-4% of grassleaf sweelflag rhizome extract, 1-2% of cassia seed extract, 1-4% of red ginseng extract, 1-4% of safflower extract, 1-5% of glossy privet fruit extract and the balance of water.

As a preferable technical scheme, the eyesight improving liquid is prepared from the following raw materials, by weight, 1-2% of radix ophiopogonis extract, 1-3% of medlar extract and 1-4% of gardenia extract.

As a preferable technical scheme of the invention, the preparation raw materials of the eyesight improving liquid also comprise 1-3% of polygala tenuifolia extract, 1-4% of liquorice extract and 1-4% of phellodendron bark extract by weight percent.

As a preferable technical scheme, the eyesight improving liquid is prepared from the following raw materials in percentage by weight, 1-2% of poria with hostwood extract, 1-2% of red sage root extract and 1-2% of radix aucklandiae extract.

As a preferable technical scheme of the invention, the eyesight improving liquid is prepared from the following raw materials by weight percent, 1-2% of plantain seed extract and 1-3% of gentian extract.

As a preferable technical scheme, the eyesight improving liquid is prepared from the following raw materials in percentage by weight, 1-3% of agilawood extracting solution and 1-3% of wormwood extracting solution.

As a preferable technical scheme of the invention, the eyesight improving liquid is prepared from the following raw materials in percentage by weight, 1-2% of cistanche deserticola extract and 1-5% of schisandra chinensis extract.

As a preferable technical scheme of the invention, the preparation raw materials of the eyesight improving liquid comprise 1-2% of weeping forsythiae capsule extract and 1-2% of pricklyash peel extract by weight percent.

The flos Chrysanthemi Indici is perennial herb of Compositae, and has effects of dispelling pathogenic wind and heat, and detumescence and removing toxic substances. Contains volatile oil, flos Chrysanthemi Indici lactone, buddleja officinalis glycoside, flos Chrysanthemi Indici alcohol, and flos Chrysanthemi Indici triol (chrysanthediol). Grassleaf sweelflag rhizome belongs to grassleaf plants, and contains beta-asarone, cis-methyl isoeugenol, elemene, asarone, delta-piper camptothecine, thymol and falcate working acid. Semen Cassiae is dry mature seed of Cassia Torae semen or Cassia tora L.of Leguminosae, and can be used for treating conjunctival congestion, pain, photophobia, lacrimation, dim eyesight, etc. The Ginseng radix Rubri is perennial herb of Panax of Araliaceae, contains triterpene saponin, volatile oil, polysaccharide, amino acid, etc. Fructus Ligustri Lucidi is fruit of Ligustrum lucidum ait of Oleaceae. Safflower, a plant of the family Compositae of the order platycodon, contains chlorogenic acid, gankemic acid, and also contains safflower polysaccharide linked by glucose, xylose, arabinose and galactose (galactose) in beta-chain. Radix Ophiopogonis, and perennial evergreen herb of genus Ophiopogon of family Liliaceae, contains ophiopogonin, glucose, amino acid, steroid saponin, sitosterol, alkaloid, etc., and has effects of relieving fatigue and scavenging free radicals. The plant of Lycium in Solanaceae contains Lycium polysaccharide, betaine, atropine, hyoscyamine, and has good taste. Fructus Gardeniae is fruit of Gardenia jasminoides Ellis of Rubiaceae, and has effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting diuresis, etc. Polygala tenuifolia, polygala tenuifolia of Polygalaceae, contains tenuifolin, xanthone, oligosaccharide ester and alkaloid, and has effects of tranquilizing mind, improving intelligence and detumescence. Glycyrrhrizae radix is dry root and rhizome of Glycyrrhrizae radix of Leguminosae, has glycyrrhizic acid, glycyrrhizin, etc., and has effects of clearing heat, detoxicating, and relieving spasm and pain. Cortex Phellodendri is dry bark of cortex Phellodendri of Rutaceae, and has effects of clearing heat and eliminating dampness. The invention can fully exert the eyesight improving effect by controlling the composition and the dosage of raw materials, and simultaneously can increase the viscosity of the eyesight improving liquid and the effects of substances such as micromolecular alcohol or alkali and the like, thereby promoting the dispersion of indissolvable oily components, avoiding the increase of turbidity of the eyesight improving liquid caused by aggregation and obtaining the higher compatible, clear and transparent eyesight improving liquid.

In addition, the invention adopts natural plant sources, is safe and nontoxic, can contact human mucosa, can extract various effective components from fructus zanthoxyli and fructus forsythiae without any irritation or anaphylactic reaction to human body, can resist various microorganisms such as bacteria, fungi, viruses, parasites and the like, and can realize zero addition of preservative. The pricklyash peel extract contains active ingredients such as limonene, cumyl alcohol, longniu alcohol, phytosterol, benzoic acid, unsaturated organic acid, dioscin, alkaloid and the like, which are easy to penetrate through a cell membrane structure, interfere the permeability of a microbial cell membrane, prevent the absorption of amino acid by the cell membrane, and cause the physiological activity of the microorganism to be disordered, thereby playing a role in bacteriostasis. The fructus forsythiae extract contains hypericin, triterpenoid saponin, phytosterol, forsythol, alkaloid, saponin, oleanolic acid, coumarone, abundant vitamins and small amount of volatile oil as active ingredients. They can permeate cell membranes to cell bodies, denature proteins, and thus exert an antibacterial effect. Hypericin has broad-spectrum antibacterial effect, has strong inhibition effect on staphylococcus aureus and shigella dysenteriae, has inhibition effect on typhoid bacillus, vibrio cholerae, escherichia coli, pseudomonas aeruginosa, pertussis bacillus, tubercle bacillus, pneumococcus and hemolytic streptococcus, and has inhibition effect on influenza virus.

As a preferable technical scheme of the invention, the preparation raw materials of the eyesight improving liquid are prepared by distillation extraction or supercritical extraction. The various extracts in the eyesight improving liquid are extracted by a water distillation extraction or supercritical extraction method well known in the art and are obtained after filtration, wherein the weight ratio of each plant to water in the extraction process is 1:0.8 to 1.2.

The invention provides a preparation method of the plant extract eyesight-improving liquid, which comprises the following steps: mixing the preparation raw materials of the eyesight improving liquid to obtain the eyesight improving liquid.

Compared with the prior art, the invention has the following beneficial effects:

(1) The invention provides an eyesight improving liquid, which takes wild chrysanthemum extract as a monarch drug and is supplemented with a plurality of components such as grassleaf sweelflag rhizome extract, cassia seed extract, red ginseng extract, safflower extract, glossy privet fruit extract and the like, can fully play roles of improving eyesight, diminishing inflammation, relieving eye swelling and pain and the like, and can not stimulate eyes and has mild effect.

(2) The invention adopts simple water distillation extraction or supercritical extraction, the preparation method is simple, the inventor discovers that after the components of each plant extract are different and water is added for mixing, partial substances are separated out, especially in the process of gradually reducing the temperature, and the problems of separation and the like can be effectively reduced by adding the dwarf lilyturf tuber extract, the medlar extract, the liquorice extract and the like, so that the eyesight improving liquid is promoted to be kept clear and transparent.

(3) In addition, the taste of each component of the invention is different and even conflicts with the wild chrysanthemum extract to influence the taste sense when in use, and the invention can improve the smell of the eyesight improving liquid and reduce the irritation by adding the poria with hostwood extract, the red sage root extract, the costustoot extract and the like, thereby improving the eyesight improving effect of the eyesight improving liquid.

(4) In order to improve the storage time, chemical preservative components are generally added into the eyesight improving liquid to reduce the problems of bacterial growth and the like after the eyesight improving liquid is opened, but the eyesight improving liquid is unfavorable for eyes.

(5) The eyesight improving liquid is clear and transparent, has stable pH and stability, can not generate precipitation and the like when being subjected to the effects of centrifugation and the like, and can rapidly play roles of improving eyesight.

Drawings

FIG. 1 shows the results of skin blood flow measurement.

FIG. 2 shows the results of measurement of the moisture content of the stratum corneum.

Fig. 3 is a skin texture measurement of a subject.

Fig. 4 is a skin texture measurement of another subject.

Detailed Description

Examples

The raw materials used in the embodiment are all prepared by a water distillation extraction method, and the specific preparation method comprises the steps of crushing plants, adding the crushed plants and mixing the crushed plants with the plants according to the weight ratio of 1:1, distilling and extracting for 1-2 h, and filtering (2000 mesh screen) to obtain the plant extract.

Example 1

The plant extract eyesight improving liquid is prepared from the following raw materials in percentage by weight.

The example also provides a preparation method of the plant extract eyesight-improving liquid, which comprises the following steps: mixing the preparation raw materials of the eyesight improving liquid to obtain the eyesight improving liquid.

Example 2

Example 3

Example 4

Evaluation of Performance

1. Skin blood flow measurement: the effect of the eyesight-improving fluid provided in example 1 on blood flow and nutrient delivery in the eyes was monitored by measuring Skin Blood Flow (SBF). The change in skin blood flow in the area where the improving eyesight liquid is used is measured by a laser doppler blood flow meter (laser doppler can monitor the blood perfusion amount of the whole microcirculation system, including capillaries (nutrient blood flow), arterioles, venules and anastomotic branches).

Test object: 15 healthy adults, 6 men and 9 women, aged 20-25 years, were tested.

The test method comprises the following steps: the laser center of the laser Doppler blood flow meter is used for measuring the skin around eyes, and the blood flow change before the eye brightening liquid is used. Blood flow values were measured for 5 minutes and recorded for the first and fifth minutes. Then, after applying the eye-improving liquid to the skin around the eyes, the blood flow changes were measured at 2 minutes, five minutes, 10 minutes, and 15 minutes, respectively, and recorded for analysis, and the results are shown in fig. 1.

Conclusion of the test: the skin blood flow changes slightly from 1min to 5min before the eyesight improving liquid was used, and an increase in blood flow started to be seen clearly after 2 min after the eyesight improving liquid was used.

2. Skin stratum corneum moisture content determination: skin conductance was measured using the SKICON-200 method to measure the moisture content of the stratum corneum to reflect changes in the number of fine lines and improvement in skin elasticity.

Test object: 20 healthy subjects, aged 19-55 years, were randomly divided into two groups, one group was not used with the eyesight improving liquid and the other group was used with the eyesight improving liquid provided in example 1, and the subjects were applied once daily in the morning and evening, requiring even application of the product, and no other skin care products were applied during the period.

The test method comprises the following steps: the skin stratum corneum moisture content was measured at 0,2,4,8 weeks of the test, and the subjects were asked to evaluate the condition and the subject. The test requires the ambient temperature to be about 20-25 degrees and the relative humidity to be 40-50%, and the test is carried out by cleaning the skin around the eyes during the measurement.

Measurement of the moisture content of the stratum corneum: the skin conductance is measured by a SKICON-200 high frequency conductance measuring instrument, and the water content of the epidermis is indirectly measured by detecting the conductivity of the skin to a high frequency current of 3.5 MHz. The conductivity and measured stratum corneum moisture correlation coefficient of up to 0.99 allows for very sensitive measurement of stratum corneum moisture, 7 consecutive measurements around the eye, pouch position, and averaging after maximum and minimum removal, as shown in figure 2.

Conclusion of the test: the moisture content of the skin cuticle tended to decrease 0 to 8 weeks before the use of the conditioning fluid, and a significant increase in moisture content began 2 weeks after the use of the conditioning fluid.

3. Skin texture measurement: subjective skin texture evaluation was determined by the method of clinical scoring. The method comprises the following steps: 1. the skin condition around the eyes is used as a criterion for the skin aging characteristics, and the skin aging condition is ranked according to the skin wrinkles and the skin condition. 2. Female volunteers 25-45 years old were randomly selected. 3. The subjects were allowed to wash their faces and to take pictures of the same parts around their eyes in a constant temperature and humidity environment at a temperature of about 22 ℃ and a humidity of 50% for 20 min. 4. The subjects apply the eyesight improving liquid once in the morning and evening every day, the product is required to be uniformly applied, no other skin care products are applied during the period, and the service period is 4 weeks. 5. After four weeks, the pictures before and after the comparison judge the anti-aging and anti-wrinkle effects of the eyesight improving liquid, and the results are shown in fig. 3 and 4, and the eyesight improving liquid provided by the embodiment 1 of the invention can effectively reduce wrinkles around eyes and promote fine skin textures.

4. Cooling stability: the eyesight-improving liquid provided in examples was cooled from 60 to 5℃at a cooling rate of 1℃per minute, and whether or not there were problems such as precipitation or decrease in transparency of the solution was observed, and it was found that examples 1 to 2 were free from precipitation or decrease in transparency, and that example 3 was poor in transparency.

5. Microorganism breeding: the eyesight improving liquid provided in examples 1 to 2 was left at room temperature for 15 days, and the turbidity change before and after leaving was observed, and found to be less than 0.02, whereas the turbidity change in example 4 was 0.08.

The test result shows that the eyesight improving liquid provided by the invention has good eyesight improving, relieving and anti-inflammatory effects.

Claims

1. The plant extract for reducing periocular wrinkles is characterized by comprising the following raw materials, by weight, 10% of wild chrysanthemum extract, 4% of grassleaf sweelflag rhizome extract, 2% of cassia seed extract, 4% of red ginseng extract, 4% of safflower extract, 5% of glossy privet fruit extract, 2% of dwarf lilyturf tuber extract, 3% of medlar extract, 4% of gardenia extract, 3% of polygala tenuifolia extract, 4% of liquorice extract, 4% of amur corktree bark extract, 2% of poria with hostwood extract, 2% of red sage root extract, 2% of costustoot extract, 2% of plantain seed extract, 3% of gentian extract, 3% of agilawood extract, 3% of wormwood extract, 2% of cistanche deserticola extract, 5% of schisandra chinensis extract, 2% of weeping forsythia extract, 2% of pricklyash peel extract and the balance of water;

the plant extract is prepared from the raw materials by distillation extraction or supercritical extraction.

2. A method for preparing a plant extract for reducing periocular wrinkles according to claim 1, characterized by comprising the steps of: mixing the preparation raw materials of the plant extract to obtain the plant extract.