CN112190512A - Preparation method and application of eye cream with remarkable curative effect on dark eye circles and under-eye puffiness - Google Patents

Abstract

The invention belongs to the field of skin care, and particularly relates to a preparation method and application of eye cream with a remarkable curative effect on dark circles and under-eye puffiness. The preparation method comprises extracting active ingredients of semen Persicae, filtering, concentrating, preparing ointment matrix, dissolving and dispersing aescin and semen Persicae extract in water, adding matrix, stirring, and homogenizing. The eye cream contains aescin and peach kernel extract. The eye cream has the effects of resisting oxidation, improving eye blood circulation and removing dark eye circles and bags.

Description

Preparation method and application of eye cream with remarkable curative effect on dark eye circles and under-eye puffiness

Technical Field

The invention belongs to the field of skin care, and particularly relates to a preparation method and application of eye cream with a remarkable curative effect on black eye circles and under-eye puffiness.

Background

The formation of dark circles is related to the following factors: staying up all night, sleeping insufficiently, eyestrain excessively, making eyelids in a tense and contracted state, making eyes not rest, increasing blood flow of the part for a long time, and causing blood vessels of subcutaneous tissues of the eyelids to be full, thereby causing congestion of eye circles and detention of dark shadows; aging or aging causes blood flow velocity of blood vessels of the skin of the eyes to be too slow to form stagnation; insufficient oxygen supply to tissues and excessive accumulation of metabolic waste in blood vessels can cause pigmentation of eyes. The older the person, the thinner the subcutaneous fat around the eyes becomes, so the more obvious the dark circles; for people who suffer from long-term diseases or are cured before the disease, due to weak tissues under the eyelids, the skin is easy to generate pigmentation, black eyes appear on the upper eyelid and the lower eyelid, and the prior anti-black eye-circle cosmetics in the market have more types and different effects.

The formation of the pouch is related to the following factors: the loose and atrophic skin of the eyelid and the edema of the connective tissue under the eye can cause the formation of pouches. Bags can be classified into congenital and acquired types. Acquired pouches are mainly caused by long-term increase of blood flow and unsmooth circulation of lower eyelids due to night-out, insufficient sleep and excessive eye fatigue, and cause blood vessels of eyelid subcutaneous tissues to be full, edema and fat accumulation. Congenital bags are poorly treated by conservative therapy, which can only be corrected by surgery. The bags in the eyes of most people are acquired. The traditional Chinese medicine considers that the root cause of the formation of the pouch is the weakness of the spleen and the stomach, so that the spleen and the qi are required to be strengthened and the qi is required to be supplemented for treating the acquired pouch, and the soil generated by the pouch is eliminated fundamentally.

The peach kernel is a traditional Chinese medicine, has the effects of promoting blood circulation to remove blood stasis and improving blood circulation, is used by adopting a water decoction in the traditional Chinese medicine, and is reported in documents that an ethanol extract of the traditional Chinese medicine has the effects of resisting oxidation and delaying skin aging, and has the effects of resisting skin aging, resisting oxidation, whitening and the like in cosmetics. However, it is hardly used in industrial cosmetics.

The main effective component of peach kernel is liposoluble component, peach kernel contains a large amount of grease, which can be extracted simultaneously in the extraction process, and high-temperature concentration is easy to cause deterioration, oil-water separation and inactivation.

The quillaja saponaria extract is an active component extracted from aesculus hippocastanum or Japanese chestnut, the main component is aescin or sodium aescin, and the quillaja saponaria extract has the effects of resisting inflammation, improving blood circulation, reducing vascular permeability, eliminating edema, promoting blood circulation and removing blood stasis, is mainly used in medicines at present and is almost rarely used in cosmetics.

In the process of adding the active ingredients, the addition amount of the peach kernel extract is large, and the saponin ingredients contained in the horse chestnut extract can cause emulsion breaking of cream, oil-water separation and the like.

Disclosure of Invention

The invention provides a preparation method of eye cream with remarkable effects on black eye circles and under-eye puffiness, and aims to overcome the defects of poor curative effect and high cost in the aspect of nursing eye skin in the prior art, so that the preparation method of the eye cream is simple and convenient to use, low in cost and remarkable in effect, and particularly aims at the black eye circles and under-eye puffiness of eyes.

Another object of the present invention is to provide use of a method for preparing an eye cream having a remarkable effect on black eyes and under-eye puffiness, which can effectively alleviate both black eyes and under-eye puffiness.

In order to achieve the purpose, the invention adopts the following technical measures:

a method for preparing eye cream with remarkable curative effect on dark circles and under-eye puffiness comprises the following steps:

step 1: peach kernel extract: crushing the raw material peach kernel, putting the crushed peach kernel into an extraction device, adding 10-12 times of 70-75% ethanol by weight, performing reflux extraction for 2-3 hours, repeating extraction for 2-3 times, combining extracting solutions, and performing reduced pressure concentration until the weight ratio of the peach kernel to the peach kernel extract is 2: 0.9-1;

step 2: preparation of an eye cream base aqueous phase: adding the components in the phase A into a water phase pot according to parts by weight, heating to 85-90 ℃, and stirring at 80-100 revolutions per minute until the components are completely dissolved;

and step 3: preparing an eye cream base oil phase: adding the raw materials of the components in the phase B into an oil phase pot according to the parts by weight, and heating to 85-90 ℃;

and 4, step 4: preparing an eye cream base: slowly adding the heated phase B into the phase A, wherein the weight ratio of the phase A to the phase B is 77.5-83.2: 14.65-18.65; stirring at 80-100 rpm for 20-30 minutes, homogenizing at 6000-10000 rpm for 10-20 minutes, and stirring for naturally cooling;

and 5: dissolving horse chestnut extract with water of the same weight under stirring, adding a small amount of sodium hydroxide, and stirring to clarify the solution;

step 6: adding the peach kernel extract and the solution obtained in the step 5 into the matrix obtained in the step 4, stirring for 20-30 minutes at 80-100 rpm, and homogenizing for 10-20 minutes at 6000-10000 rpm;

and 7: adding essence into the step 7, homogenizing for 10-15 minutes at 6000-10000 rpm, and naturally cooling to room temperature to obtain the eye cream;

the weight ratio of the phase A, the phase B, the peach kernel extract and the horse chestnut extract is as follows:

77.5～83.2:14.65～18.65:3.0～5.0:0.3～1.0；

the phase A comprises the following main effective components in parts by weight:

the phase B: the main effective components are as follows according to the weight portion:

the rest components are as follows according to the weight portion:

3.0-5.0 parts of peach kernel extract

0.3-1.0% of horse chestnut extract (calculated by aescin)

0.05-0.06 parts of essence;

sodium hydroxide is added to the horse chestnut extract to an amount such that the solution is clear.

The peach kernel is dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch. Harvesting after fruits are ripe, removing pulp and nucleocapsid, taking out seeds, and drying in the sun;

the Quillaja saponaria Molina extract is natural plant extract, and is prepared from dry mature seed of horse chestnut (scientific name: Aesculus wilsonii Rehd.) of Aesculus of Hippocastanaceae.

Other raw materials and auxiliary materials used in the invention are common daily chemical raw material products.

The invention also comprises the eye cream prepared by the method, and the eye cream can be used for relieving the symptoms of dark circles and/or bags under the eyes.

Compared with the prior art, the invention has the following advantages:

the traditional Chinese medicine peach kernel with the functions of promoting blood circulation to remove blood stasis and improving blood circulation is prepared into eye cream by adopting an optimized process and extracting active ingredients with the functions of resisting oxidation, delaying skin aging, whitening and the like by using ethanol, and the eye cream is matched with the aesculus chinensis extract with the functions of resisting inflammation, improving blood circulation, reducing vascular permeability, eliminating edema, promoting blood circulation to remove blood stasis and is used for improving dark eye circles and under-eye puffiness caused by eye fatigue, insufficient sleep and the like.

Detailed Description

In order to make those skilled in the art better understand the technical solution of the present invention, the following detailed description will be given with reference to specific embodiments. In the embodiment of the invention, the traditional Chinese medicine extracting and concentrating equipment comprises: TN50, emulsifying pan: YH-5L; extracting solvent: ethanol (95%) pharmaceutical grade, purified water; horse chestnut extract was purchased from commercial sources; the remainder are not specified in detail and are conventional reagents or procedures in the art.

Example 1:

the eye cream prepared by the invention has the following curative effect difference with other reference substances on black eyes and under-eye puffiness:

an eye cream having a remarkable effect on dark circles and under-eye puffiness, which is prepared by the steps of:

step 1: peach kernel extract: pulverizing semen Persicae, placing in an extraction device, adding 10 times of 70% ethanol, reflux extracting for 2 hr, repeating the extraction for 2 times, mixing extractive solutions, and concentrating under reduced pressure at 60 deg.C until the weight ratio of semen Persicae to semen Persicae extract is 2: 1.

Step 2: preparation of an eye cream base aqueous phase: and (3) adding the components in the phase A into a water phase pot according to weight, heating to 85 ℃, and stirring at 100 revolutions per minute until the components are completely dissolved.

And step 3: preparing an eye cream base oil phase: adding the raw materials of the components in the phase B into an oil phase pot according to weight parts respectively, and heating to 85 ℃;

and 4, step 4: preparation of eye cream base heated phase B was slowly added to phase A at a weight ratio of phase A to phase B of 81.6: 16.7. Stirring at 100 rpm for 30 minutes, homogenizing at 6000 rpm for 10 minutes, and naturally cooling to 40 ℃;

and 5: dissolving horse chestnut extract with water of the same weight under stirring, adding a small amount of sodium hydroxide, and stirring to clarify the solution;

step 6: and (3) adding the peach kernel extract and the solution obtained in the step (5) into the matrix obtained in the step (4) in sequence, stirring for 30 minutes at 100 revolutions per minute, and homogenizing for 20 minutes at 6000 revolutions per minute.

And 7: and (4) adding essence into the product obtained in the step (6), homogenizing at 6000 rpm for 10 minutes, and naturally cooling to room temperature to obtain the eye cream.

In the embodiment of the invention, the essence type is 82320D which is universal in the cosmetic industry.

The weight ratio of the phase A, the phase B, the peach kernel extract and the horse chestnut extract is as follows: 81.6: 16.7:5.0:0.5

The phase A comprises the following components in parts by weight:

the phase B comprises the following components in parts by weight:

the rest components are as follows according to the weight portion:

control 1: in the field, the safflower also has the functions of promoting blood circulation to remove blood stasis, and modern medicine proves that the eye cream also has the functions of beautifying and removing dark circles.

Control 2:

only the extraction solvent is changed into water in the process of extracting the main effective component by 70 percent ethanol in the preparation process of the to-be-detected product, so as to investigate the influence of different extraction solvents on the effect of relieving the black eye.

Control 3:

diluting the peach kernel extract and the horse chestnut extract in the preparation process of the product to be detected into the same concentration with the peach kernel extract and the horse chestnut extract contained in the product to be detected by using a solution of 5:1 of glycerin and water, uniformly mixing, replacing the product to be detected, and using the method the same as that of the product to be detected so as to investigate the influence of the prepared eye cream on the drug effect.

The experimental scheme is as follows: selecting a certain number of volunteers, wherein the volunteers are 25-50 years old and appear as dark circles caused by fatigue staying up all night, randomly grouping and marking the volunteers into 1-4 groups, and respectively testing the to-be-tested sample and the reference sample by 1-3 20 persons in each group.

The test method comprises the following steps: the eye cream is uniformly applied to the skin surface around eyes of volunteers, 0.01g per square centimeter for 3 times per day for 30 days.

Observation indexes are as follows: the color card is used for comparing, observing and observing the change of skin color around eyes of a volunteer after the volunteer uses the color card, recording the color number, and measuring the width of a black eye ring by a caliper.

A first group: using the article to be tested

And (3) test results: the color change and width change of the dark circles after 90 days for 20 persons are shown in the following table:

to summarize: a total of 20 volunteers from the test group were used, with an age distribution of 27 to 46 years. The color of the black eye is obviously lightened after the eye-protecting mask is used, the size of the black eye is reduced, the pouch disappears, and the eyelid skin is loosened and improved.

Second group: use of control 1

And (3) test results: the color change and width change of the dark circles after 30 days in 20 persons are shown in the following table:

to summarize: a total of 20 volunteers were used as a control with an age distribution of 27 to 46 years. The color of the black eye after use is reduced to a lesser extent than that of the test sample, the size of the black eye is reduced, the size is reduced to a lesser extent than that of the test sample group, the symptom of the pouch is reduced, and the eyelid skin is flaccid.

Third group: use of control 2

And (3) test results: the color change and width change of the dark circles after 30 days in 20 persons are shown in the following table:

to summarize: a total of 20 volunteers in control 2 groups were used, with an age distribution of 25 to 42 years. The dark circles were lighter in color after application, less intense than the test samples, and the dark circles were reduced in size, less intense than the test samples, with substantial disappearance of bags and improved eyelid laxity.

And a fourth group: use control 3

And (3) test results: the color change and width change of the dark circles after 30 days in 20 persons are shown in the following table:

to summarize: a total of 20 volunteers were used as a control with an age distribution of 27 to 46 years. The color of the black eye after use is reduced to a lesser extent than that of the test sample, the size of the black eye is reduced to a lesser extent than that of the test sample group, the pouch is reduced or substantially eliminated, and the eyelid skin is improved in laxity.

The above results show that:

the effect of relieving dark circles is poor by replacing the peach kernel prescription with other plant components which have the same functions of promoting blood circulation and removing blood stasis in the eye cream, which indicates that the peach kernel cannot be simply replaced with other plant components with the same functions.

When the extraction solvent of the main effective components is changed from 70 percent ethanol to water, the treatment effect is obviously inferior to that of eye cream prepared by extracting 70 percent ethanol, which shows that the solvent of the invention is selected to better extract fat-soluble components in medicinal materials than common solvent water, and the extracted components can more easily play an important role in the treatment process of tinea pedis.

The extract can be directly used for relieving black eye and pouch. The effect is slightly worse than that of the eye cream, but the eye cream is inconvenient to use, the absorption of effective components is worse than that of the eye cream prepared by the eye cream, the stability is worse, and the eye cream can not be sold as cosmetics.

Example 2:

an eye cream having a remarkable effect on dark circles and under-eye puffiness, which is prepared by the following method:

the eye cream comprises the following main effective components in parts by weight: peach kernel extract 4.0, horse chestnut extract (calculated as aescin) 1.0.

The preparation method and parameters are the same as the preparation steps of the sample to be tested in the example 1, and the using method is the same as the example 1.

And (3) test results: 20 volunteers, all had pouches caused by fatigue and staying up overnight, and the pouch changes after 10 days of use are shown in the following table:

example 3:

an eye cream having a remarkable effect on dark circles and under-eye puffiness, which is prepared by the following method:

the eye cream comprises the following main effective components in parts by weight: peach kernel extract 3.0, horse chestnut extract (calculated as aescin) 0.3.

The preparation method and parameters are the same as the preparation steps of the sample to be tested in the example 1, and the using method is the same as the example 1.

And (3) test results: 20 volunteers, all had pouches caused by fatigue and staying up overnight, and the pouch changes after 10 days of use are shown in the following table:

the results of example 2 and example 3 show that adjusting the ratio of peach kernel extract to horse chestnut extract within the scope of the present invention does not significantly affect the use effect of the product.

The embodiments of the present invention have been described in detail, but the description is only for the preferred embodiments of the present invention and is not intended to limit the present invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.

Claims (3)

1. A method for preparing eye cream with remarkable curative effect on dark circles and under-eye puffiness comprises the following steps:

step 1: peach kernel extract: crushing a raw material of peach kernel, putting the crushed peach kernel into an extraction device, adding 70-75% ethanol which is 10-12 times of the weight of the peach kernel, performing reflux extraction for 2-3 hours, repeatedly extracting for 2-3 times, combining extracting solutions, and performing reduced pressure concentration until the weight ratio of the peach kernel to the peach kernel extract is 2: 0.9-1;

step 2: preparation of an eye cream base aqueous phase: adding the components in the phase A into a water phase pot according to parts by weight, heating to 85-90 ℃, and stirring at 80-100 r/min until the components are completely dissolved;

and step 3: preparing an eye cream base oil phase: adding the raw materials of the components in the phase B into an oil phase pot according to parts by weight, and heating to 85-90 ℃;

and 4, step 4: preparing an eye cream base: slowly adding the heated phase B into the phase A, wherein the weight ratio of the phase A to the phase B is 77.5-83.2: 14.65-18.65; stirring at 80-100 rpm for 20-30 minutes, homogenizing at 6000-10000 rpm for 10-20 minutes, and stirring for naturally cooling;

and 5: dissolving horse chestnut extract with water of the same weight under stirring, adding a small amount of sodium hydroxide, and stirring to clarify the solution;

step 6: adding the peach kernel extract and the solution obtained in the step 5 into the matrix obtained in the step 4, stirring for 20-30 minutes at 80-100 rpm, and homogenizing for 10-20 minutes at 6000-10000 rpm;

and 7: adding essence into the step 7, homogenizing for 10-15 minutes at 6000-10000 rpm, and naturally cooling to room temperature to obtain the eye cream;

the weight ratio of the phase A, the phase B, the peach kernel extract and the horse chestnut extract is as follows: 77.5-83.2: 14.65-18.65: 3.0-5.0: 0.3-1.0;

the phase A comprises the following main effective components in parts by weight:

70-73% of water

0.05-0.10 parts of phenoxyethanol

0.1-0.2 of methylparaben

0.15-0.20 parts of chlorphenesin

Acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.15-0.16

0.05-0.06 parts of sodium hyaluronate

4.0-6.0% of glycerin

3.0-3.5 parts of mannitol

The phase B: the main effective components are as follows according to the weight portion:

PEG-100 stearate 0.8-1.2

2.5-3.5% of squalane

Neopentyl glycol dicaprylate 2.0-2.5

BINESTER132 1.5~2.0

Polydimethylsiloxane 3.0-2.5

Ceteareth-202.0-2.5

0.5-1.5% of vitamin E

16/18 alcohol 1.0-1.2

Acryloyl dimethyl sodium taurate copolymer 1.2-1.5

Triethanolamine 0.15-0.16

The rest components are as follows according to the weight portion:

3.0-5.0 parts of peach kernel extract

0.3-1.0% of horse chestnut extract (calculated by aescin)

0.05-0.06 parts of essence;

sodium hydroxide is added to the horse chestnut extract to an amount such that the solution is clear.

2. Use of the method of claim 1 in the preparation of an eye cream.

3. The use according to claim 2, wherein the eye cream is used for relieving symptoms of dark under-eye circles and/or under-eye bags.