CN112791021A

CN112791021A - Whitening, black eye removing and aging delaying functional compound and preparation method thereof

Info

Publication number: CN112791021A
Application number: CN202110088802.2A
Authority: CN
Inventors: 蔡建平; 吴倩; 刘�英
Original assignee: Shanghai Jiaxin Biotechnology Co ltd
Current assignee: Shanghai Jiaxin Biotechnology Co ltd
Priority date: 2021-01-22
Filing date: 2021-01-22
Publication date: 2021-05-14
Anticipated expiration: 2041-01-22
Also published as: CN112791021B

Abstract

The application relates to the field of skin care products, and particularly discloses a compound with effects of whitening skin, removing dark circles and delaying aging and a preparation method thereof; the compound is prepared from the following raw materials in parts by weight: 15-25 parts of ginseng extract, 10-15 parts of peach kernel extract, 10-15 parts of angelica extract, 4-10 parts of caffeine, 8-16 parts of astragalus extract and 5-10 parts of heparin sodium; the preparation method comprises the following steps: weighing and mixing ginseng extract, peach kernel extract, angelica extract, astragalus extract, caffeine and heparin sodium, heating to 60-75 ℃, stirring at the rotating speed of 1000-; the eye cream has the effects of whitening, removing dark eye circles, delaying aging and the like.

Description

Whitening, black eye removing and aging delaying functional compound and preparation method thereof

Technical Field

The application relates to the field of skin care products, in particular to a compound with effects of whitening, removing dark circles and delaying senescence and a preparation method thereof.

Background

With the development of society, the life rhythm of modern people is gradually accelerated, especially for young people, the aging speed of skin is gradually accelerated due to long-term bad work such as overtime, staying up overnight and the like, so that the skin problems of black eyes and under-eye puffiness are more and more common, the beauty pursuit psychology of people makes people pay more attention to eye skin care, and eye cream is more and more popular with people.

The eye cream is a skin care product acting on eyes, has a moistening effect, can reduce the problems of black eye circles and under-eye puffiness, can improve fine lines and wrinkles, has certain effects on under-eye puffiness, black eye circles, crow's feet and the like, but has different effects on different eye creams, such as moistening eye cream, firming eye cream, moisturizing eye cream, anti-aging eye cream, anti-allergy eye cream and the like, so the eye cream in the market is generally single-function eye cream, and no eye cream has three effects of whitening, removing black eye circles, delaying aging and the like at present.

Disclosure of Invention

In order to enable the eye cream to have the effects of whitening, removing dark circles, delaying senescence and the like, the application provides a compound with the effects of whitening, removing dark circles and delaying senescence and a preparation method thereof.

In a first aspect, the application provides a compound with effects of whitening skin, removing dark circles and delaying aging, and adopts the following technical scheme:

the compound with the effects of whitening, removing dark circles and delaying senescence is prepared from the following raw materials in parts by weight: 15-25 parts of ginseng extract, 10-15 parts of peach kernel extract, 10-15 parts of angelica extract, 4-10 parts of caffeine, 8-16 parts of astragalus extract and 5-10 parts of heparin sodium.

By adopting the technical scheme, the ginseng extract and the scutellaria extract are matched, and black eye circles are fundamentally removed by inhibiting the formation of melanin; the ginseng extract, the peach kernel extract and the angelica extract are matched, so that the skin can be promoted to absorb phloretin and other functional small molecules in the ginseng, and active ingredients are enabled to permeate into the muscle bottom, so that the secretion of melanin is inhibited; the peach kernel extract, the angelica extract and the heparin sodium are matched, so that the blood circulation of the skin can be promoted, the metabolism of the skin is increased, and the melanin pigmentation and the melanin granules on the basal layer are removed; the functional micromolecules which inhibit the formation of melanin are absorbed by the skin, so that the functional micromolecules reach the skin basal layer, the formation of melanin is fundamentally inhibited, and then the melanin is eliminated by improving the metabolism of the skin, and finally the purpose of removing black eye circles is achieved.

The ginseng extract and the scutellaria extract are matched, so that the whitening effect is good, the skin metabolism can be promoted, the skin elasticity can be improved, and the skin aging can be delayed; the heparin sodium, the peach kernel extracting solution, the Chinese angelica extracting solution and the caffeine are matched, so that the absorption and the preservation of nutrients by skin can be promoted, the skin has good heat preservation and moistening effects, the excretion of metabolic wastes is promoted, and the anti-wrinkle effect is good.

Preferably, the compound also comprises the following raw materials in parts by weight: 1-2 parts of borneol and 0.5-1.5 parts of azone.

By adopting the technical scheme, the borneol and the azone are matched to promote the ginsenoside in the ginseng extract and the baicalin and other components in the scutellaria baicalensis extract to permeate into the dermis; the ginsenoside and baicalin are not strong in lipophilicity, and the borneol can change the arrangement of lipid molecules so as to increase the fluidity of the lipid molecules, and the essential oil and other functional components in the ginseng extract and the peach kernel extract are matched to improve the hydration of the skin, so that the ginsenoside and baicalin can be finally promoted to penetrate through the horny layer and permeate into the dermis layer, thereby inhibiting the formation of melanin, recovering the elasticity of the skin, promoting the metabolism of the skin, and enabling the skin to have good effects of whitening, removing dark circles and delaying aging.

Preferably, the borneol is natural borneol.

By adopting the technical scheme, the natural borneol is a crystal obtained by extracting resin and volatile oil of borneol of a borneol family plant, namely borneol, and is almost pure d-borneol, so that the permeation effect of ginsenoside and baicalin is improved; and the natural borneol does not contain heavy metal, so that the eye cream is safer to use when being prepared into eye cream.

Preferably, the compound also comprises the following raw materials in parts by weight: 1-3 parts of azone modified bacterial cellulose, 0.5-1 part of polyvinyl alcohol, 1-2 parts of loading mesoporous nano silicon dioxide and 8-14 parts of water; baicalin is loaded in pores of the material-loading mesoporous nano-silica.

By adopting the technical scheme, the material-carrying mesoporous nano silicon dioxide, the azone modified bacterial cellulose and the polyvinyl alcohol are matched, the material-carrying mesoporous nano silicon dioxide is adhered to the surface of the azone modified bacterial cellulose by utilizing the adhesive property of the polyvinyl alcohol, when the baicalin in the mesoporous nano silicon dioxide is gradually released, the active ingredient is contacted with the azone on the surface of the bacterial cellulose, and the baicalin is enabled to gradually penetrate through the horny layer and permeate to the dermis layer by matching with the higher permeation effect of the azone, so that the effect of inhibiting melanin generation for a long time is achieved, the active ingredient is prevented from permeating to the dermis layer due to the fact that the cell metabolism speed is accelerated, and the action time of the active ingredient is shortened.

Because the mesoporous nano-silica has deeper pores and higher loaded baicalin content, before the baicalin is gradually released, the bacterial cellulose connects the loaded mesoporous nano-silica to form a compact reticular structure, so that ultraviolet rays in the external environment can be isolated, the skin melanin is prevented from being deposited in a large amount by the irradiation of the ultraviolet rays, melanocytes are activated, the compound can avoid the formation of black eye circles by isolating the ultraviolet rays, and the compound has the effect of removing the black eye circles.

Preferably, the azone modified bacterial cellulose is prepared by the following method: weighing 1-3 parts of bacterial cellulose, soaking in 10-15 parts of azone for 1-3min, and air-drying at 40 ℃ for 1-3min to obtain the modified bacterial cellulose.

Through adopting above-mentioned technical scheme, place bacterial cellulose in azone solution and soak, because bacterial cellulose has stronger adsorption, can adsorb azone material in a large number to make azone material attached to bacterial cellulose surface, after azone is air-dried and is attached to bacterial cellulose surface, make azone modified bacterial cellulose.

Preferably, the loading mesoporous nano-silica is prepared by the following method:

weighing 0.1-0.2 part of hexadecyl trimethoxy ammonium bromide, dissolving the hexadecyl trimethoxy ammonium bromide into 150 parts of deionized water, adding 3-5 parts of ammonia water, and magnetically stirring at 40 ℃ for 25-35min to prepare a stirring solution;

weighing 1-1.5 parts of tetraethyl silicate, placing the tetraethyl silicate in the prepared stirring liquid, stirring for 3-5h, centrifuging, washing for 2-5 times, drying in vacuum, and calcining at 800 ℃ for 1-3h to obtain a product, thus obtaining the mesoporous nano-silica;

thirdly, weighing 1-3 parts of baicalin, 1-2 parts of sodium alginate and 4-10 parts of mesoporous nano-silica, placing the materials in 60-75 parts of water for ultrasonic dispersion for 5-10min, and drying to obtain the material-carrying mesoporous nano-silica.

By adopting the technical scheme, baicalin and mesoporous nano-silica are matched with ultrasonic dispersion, so that a large amount of baicalin is dispersed in pores of the mesoporous nano-silica; baicalin, sodium alginate and mesoporous nano-silica are matched, baicalin is attached to pores of the mesoporous nano-silica by utilizing the better adhesive property of an aqueous solution of the sodium alginate, and after drying, a large amount of baicalin active ingredients are contained in the pores of the mesoporous nano-silica, so that the slow release of the baicalin active ingredients can be realized.

Preferably, the stirring is carried out for 2-5min at the rotating speed of 600-800r/min before the ultrasonic dispersion.

By adopting the technical scheme, the sodium alginate is dissolved in the water by stirring before ultrasonic dispersion to prepare the sodium alginate solution, and the dissolved sodium alginate has the adhesive property, so that the baicalin can be stably adhered to the pores of the mesoporous nano-silica during ultrasonic dispersion.

In a second aspect, the application provides a preparation method of a compound with effects of whitening skin, removing dark circles and delaying aging, which adopts the following technical scheme:

a preparation method of a compound with effects of whitening, removing dark circles and delaying aging comprises the following steps:

s1, weighing azone modified bacterial cellulose, polyvinyl alcohol and loading mesoporous nano silicon dioxide, mixing, placing in water, mixing and stirring, ultrasonically dispersing for 1-3min, and standing for 3-5min to obtain a mixture;

s2, weighing the ginseng extract, the peach kernel extract, the angelica extract, the astragalus extract, the caffeine and the heparin sodium, putting the ginseng extract, the peach kernel extract, the angelica extract, the astragalus extract, the caffeine and the heparin sodium into the mixture prepared in the S1, heating to 60-75 ℃, and stirring for 5-10min at the rotating speed of 1000-1500r/min to prepare a finished compound product.

By adopting the technical scheme, the azone modified bacterial cellulose, the polyvinyl alcohol and the loading mesoporous nano silicon dioxide are placed in water, the polyvinyl alcohol is dissolved in the water, the loading mesoporous nano silicon dioxide is attached to the surface of the azone modified bacterial cellulose by utilizing the adhesive property of the polyvinyl alcohol, so that the baicalin active ingredients released from pores of the mesoporous nano silicon dioxide are enabled to be matched with the higher penetration effect of the azone on the surface of the bacterial cellulose, the baicalin active ingredients in the mesoporous nano silicon dioxide can be gradually penetrated into a dermis layer, and the generation of melanin is inhibited for a long time.

The mixture is mixed with ginseng extract, peach kernel extract, angelica extract, astragalus extract, caffeine and heparin sodium to prepare a finished product of the compound, and the operation is simple and convenient, and the enterprise production is easy.

In summary, the present application has the following beneficial effects:

1. the ginseng extract, the scutellaria baicalensis extract, the peach kernel extract, the angelica sinensis extract, the caffeine and the heparin sodium are matched, so that the prepared compound has the effects of whitening, removing dark circles and delaying senescence.

2. The borneol, the ginseng extract and the scutellaria baicalensis extract are matched, so that the antibacterial and bacteriostatic effects are good, the skin is prevented from being infected by microorganisms such as corynebacteria, staphylococcus and mites due to unclean cleaning, the antibacterial and bacteriostatic effects can be achieved on the surface of the skin, and bacterial infection in the skin can be avoided along with the permeation of the borneol, the ginsenoside and the baicalin, so that the skin is healthier, smoother and more delicate.

3. The bacterial cellulose, the baicalin and the mesoporous nano-silica are matched, so that the antibacterial and bacteriostatic properties are good; and the azone modified bacterial cellulose and the ginseng extract are matched, so that the skin can be deeply moistened, the skin elasticity can be recovered, and the skin is tight and smooth.

Detailed Description

The present application will be described in further detail with reference to examples.

Preparation example of bacterial cellulose

The yeast in the raw materials of the following preparation examples was purchased from Ningbo boat Biotechnology Co., Ltd, Acetobacter xylinum was purchased from Goodel chemical Co., Ltd, and other raw materials were all generally commercially available.

Preparation example 1: the bacterial cellulose is prepared by the following method:

weighing 120kg of coconut juice, inoculating 0.4kg of yeast, fermenting for 26 hours at 28 ℃, sterilizing for 20min at 121 ℃ to obtain a yeast culture solution, inoculating 8kg of acetobacter xylinum into the yeast culture solution, performing aeration culture for 18 hours, standing and culturing for 5.5 days, and taking out suspended substances on the surface of the culture solution to obtain bacterial cellulose.

Preparation example 2: the bacterial cellulose is prepared by the following method:

weighing 110kg of coconut juice, inoculating 0.4kg of yeast, fermenting for 26 hours at 28 ℃, sterilizing for 20min at 121 ℃ to obtain a yeast culture solution, inoculating 8kg of acetobacter xylinum into the yeast culture solution, performing aeration culture for 18 hours, standing and culturing for 5.5 days, and taking out suspended substances on the surface of the culture solution to obtain bacterial cellulose.

Preparation example 3: the bacterial cellulose is prepared by the following method:

130kg of coconut juice is weighed, 0.4kg of yeast is inoculated, fermentation is carried out for 26 hours at the temperature of 28 ℃, sterilization is carried out for 20 minutes at the temperature of 121 ℃ to prepare yeast culture solution, 8kg of acetobacter xylinum is inoculated into the yeast culture solution, aeration culture is carried out for 18 hours, then static culture is carried out for 5.5 days, and suspended substances on the surface of the culture solution are taken out to prepare bacterial cellulose.

Preparation of Azone-modified bacterial cellulose Azone of the following raw materials was purchased from water-soluble Azone produced by Wabon Natural flavors, Inc. of Jiangxi; other raw materials and equipment are all sold in the market.

Preparation example 4: the azone modified bacterial cellulose is prepared by the following method:

weighing 2kg of bacterial cellulose prepared in the preparation example 1, placing the bacterial cellulose in 12kg of azone, soaking the bacterial cellulose in the azone at a rotating speed of 350r/min, stirring the bacterial cellulose for 2min, and air-drying the bacterial cellulose at 40 ℃ for 2min to obtain the modified bacterial cellulose.

Preparation example 5: the azone modified bacterial cellulose is prepared by the following method:

weighing 1kg of bacterial cellulose prepared in the preparation example 2, placing the bacterial cellulose in 10kg of azone, soaking the bacterial cellulose in the azone at the rotating speed of 350r/min, stirring the bacterial cellulose for 1min, and air-drying the bacterial cellulose at the temperature of 40 ℃ for 1min to obtain the modified bacterial cellulose.

Preparation example 6: the azone modified bacterial cellulose is prepared by the following method:

3kg of the bacterial cellulose prepared in the preparation example 3 is weighed, soaked in 15kg of azone at the rotating speed of 350r/min, stirred for 3min, and air-dried at 40 ℃ for 3min to obtain the modified bacterial cellulose.

Preparation example of loading mesoporous nano-silica cetyl trimethoxyammonium bromide in the following raw materials was purchased from Shanghai Xuejie chemical Co., Ltd, model 1631 bromine; ammonia was purchased from Chengdu Bosheng chemical Co., Ltd; tetraethyl silicate is purchased from Jinan Hencui New Material Co., Ltd, and the content is 99%; baicalin is purchased from Shanxi Hao Chen Biotech Co., Ltd, and has a content of 85%; other raw materials and equipment are all sold in the market.

Preparation example 7: the material-carrying mesoporous nano silicon dioxide is prepared by the following method:

weighing 0.16kg of hexadecyl trimethoxy ammonium bromide, dissolving the hexadecyl trimethoxy ammonium bromide into 140kg of deionized water, adding 4kg of ammonia water with the mass fraction of 15%, and magnetically stirring the mixture for 30min at 40 ℃ to prepare a stirring solution;

weighing 1.22kg of tetraethyl silicate, placing the tetraethyl silicate in the prepared stirring solution, stirring for 4 hours at the temperature of 28 ℃ and the speed of 1200r/min, centrifuging, washing for 3 times by using deionized water, drying at the temperature of 40 ℃ in vacuum, placing the mixture in a muffle furnace, and calcining for 2 hours at the temperature of 650 ℃ to obtain a product, thus obtaining mesoporous nano-silica;

thirdly, weighing 2kg of baicalin, 1.6kg of sodium alginate and 8kg of the mesoporous nano-silica prepared by the second step, placing the obtained mixture in 70kg of water, stirring for 4min at the rotating speed of 700r/min, then performing ultrasonic dispersion for 8min, and drying at room temperature to obtain the loading mesoporous nano-silica.

Preparation example 8: the material-carrying mesoporous nano silicon dioxide is prepared by the following method:

weighing 0.1kg of hexadecyl trimethoxy ammonium bromide, dissolving the hexadecyl trimethoxy ammonium bromide into 130kg of deionized water, adding 3kg of ammonia water with the mass fraction of 15%, and magnetically stirring the mixture for 25min at 40 ℃ to prepare a stirring solution;

weighing 1kg of tetraethyl silicate, placing the tetraethyl silicate in the prepared stirring solution, stirring for 3 hours at 25 ℃ and 1200r/min, centrifuging, washing for 2 times by using deionized water, drying at 40 ℃ in vacuum, placing the mixture in a muffle furnace, and calcining for 1 hour at 500 ℃ to obtain mesoporous nano-silica;

thirdly, weighing 1kg of baicalin, 1kg of sodium alginate and 4kg of the prepared mesoporous nano-silica, placing the obtained product in 60kg of water, stirring for 2min at the rotating speed of 600r/min, then performing ultrasonic dispersion for 5min, and drying at room temperature to obtain the loading mesoporous nano-silica.

Preparation example 9: the material-carrying mesoporous nano silicon dioxide is prepared by the following method:

weighing 0.2kg of hexadecyl trimethoxy ammonium bromide, dissolving the hexadecyl trimethoxy ammonium bromide into 150kg of deionized water, adding 5kg of ammonia water with the mass fraction of 15%, and magnetically stirring for 35min at 40 ℃ to prepare a stirring solution;

weighing 1.5kg of tetraethyl silicate, placing the tetraethyl silicate in the prepared stirring solution, stirring for 5 hours at 26 ℃ and 1200r/min, centrifuging, washing for 5 times by using deionized water, drying at 40 ℃ in vacuum, placing the mixture in a muffle furnace, and calcining for 3 hours at 800 ℃ to obtain a product, thus obtaining the mesoporous nano-silica;

thirdly, 3kg of baicalin, 2kg of sodium alginate and 10kg of the mesoporous nano-silica prepared by the third step are weighed and placed in 75kg of water to be stirred for 5min at the rotating speed of 800r/min, then the mixture is ultrasonically dispersed for 10min, and the material-carrying mesoporous nano-silica is prepared after drying at room temperature.

Examples

The ginseng extract in the following raw materials is purchased from Guangzhou city rain and dew chemical company Limited, and the content is not less than 98 percent; peach kernel extract was purchased from Jiangxi Tianmei perfume oil Co., Ltd; the angelica extract is purchased from angelica extract produced by Shaanxi Murphy Biotech limited, and the content is 98 percent; scutellariae radix extractive solution is purchased from Guangzhou Minyue Biotechnology GmbH; the heparin sodium is purchased from food-grade heparin sodium produced by Baiying biotechnology limited in Jiangxi; the natural borneol and the synthetic borneol are purchased from Ji' an Yufeng natural plant spice Co Ltd, and the purity is 99 percent; polyvinyl alcohol was purchased from Kyon chemical Co., Ltd; other raw materials and equipment are all sold in the market.

Example 1: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 20kg of ginseng extract, 12kg of peach kernel extract, 12kg of angelica extract, 11kg of astragalus extract, 7kg of caffeine and 8kg of heparin sodium, mixing, heating to 70 ℃, and stirring for 8min at the rotating speed of 1250r/min to obtain the finished compound.

Example 2: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 15kg of ginseng extract, 10kg of peach kernel extract, 10kg of angelica extract, 8kg of astragalus extract, 4kg of caffeine and 5kg of heparin sodium, mixing, heating to 60 ℃, and stirring for 5min at the rotating speed of 1000r/min to obtain the finished compound.

Example 3: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 25kg of ginseng extract, 15kg of peach kernel extract, 15kg of angelica extract, 16kg of astragalus extract, 10kg of caffeine and 10kg of heparin sodium, mixing, heating to 75 ℃, and stirring at the rotating speed of 1500r/min for 10min to obtain the finished compound.

Example 4: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 20kg of ginseng extract, 12kg of peach kernel extract, 12kg of angelica extract, 11kg of astragalus extract, 7kg of caffeine, 8kg of heparin sodium, 1.6kg of natural borneol and 1.1kg of azone, mixing, heating to 70 ℃, and stirring for 8min at the rotating speed of 1250r/min to obtain a finished compound product.

Example 5: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 15kg of ginseng extract, 10kg of peach kernel extract, 10kg of angelica extract, 8kg of astragalus extract, 4kg of caffeine, 5kg of heparin sodium, 1kg of synthetic borneol and 0.5kg of azone, mixing, heating to 60 ℃, and stirring at the rotating speed of 1000r/min for 5min to obtain the finished compound.

Example 6: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 25kg of ginseng extract, 15kg of peach kernel extract, 15kg of angelica extract, 16kg of astragalus extract, 10kg of caffeine, 10kg of heparin sodium, 2kg of synthetic borneol and 1.5kg of azone, mixing, heating to 75 ℃, and stirring at the rotating speed of 1500r/min for 10min to obtain the finished compound.

Example 7: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 2kg of azone modified bacterial cellulose prepared in preparation example 4, 0.8kg of polyvinyl alcohol and 1.6kg of loading mesoporous nano-silica prepared in preparation example 7, mixing, putting into 10kg of water, mixing and stirring, performing ultrasonic dispersion for 2min under the condition of 20kHz, and then standing for 4min to obtain a mixture;

s2, weighing 20kg of ginseng extract, 12kg of peach kernel extract, 12kg of angelica extract, 11kg of astragalus extract, 7kg of caffeine, 8kg of heparin sodium, 1.6kg of natural borneol and 1.1kg of azone, mixing in the mixture prepared in the S1, heating to 70 ℃, and stirring at the rotating speed of 1250r/min for 8min to obtain a finished compound product.

Example 8: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 1kg of azone modified bacterial cellulose prepared in preparation example 5, 0.5kg of polyvinyl alcohol and 1kg of loading mesoporous nano-silica prepared in preparation example 8, mixing, placing in 8kg of water, mixing and stirring, performing ultrasonic dispersion for 1min under the condition of 20kHz, and then standing for 3min to obtain a mixture;

s2, weighing 15kg of ginseng extract, 10kg of peach kernel extract, 10kg of angelica extract, 8kg of astragalus extract, 4kg of caffeine, 5kg of heparin sodium, 1kg of synthetic borneol and 0.5kg of azone, mixing in the mixture prepared in S1, heating to 60 ℃, and stirring at the rotating speed of 1000r/min for 5min to obtain the finished compound product.

Example 9: a preparation method of a compound with efficacies of whitening skin, removing dark circles and delaying aging comprises the following steps:

s1, weighing 3kg of azone modified bacterial cellulose prepared in preparation example 6, 1kg of polyvinyl alcohol and 2kg of loading mesoporous nano-silica prepared in preparation example 9, mixing, placing in 14kg of water, mixing and stirring, performing ultrasonic dispersion for 3min under the condition of 20kHz, and then standing for 5min to obtain a mixture;

s2, weighing 25kg of ginseng extract, 15kg of peach kernel extract, 15kg of angelica extract, 16kg of astragalus extract, 10kg of caffeine, 10kg of heparin sodium, 2kg of synthetic borneol and 1.5kg of azone, mixing the materials in the mixture prepared in the S1, heating to 75 ℃, and stirring at the rotating speed of 1500r/min for 10min to obtain a finished compound product.

Comparative example

Comparative example 1: the difference between this comparative example and example 1 is that the ginseng extract was replaced with the same mass of the scutellaria extract as the raw material.

Comparative example 2: the difference between this comparative example and example 1 is that the ginseng extract was replaced with an angelica extract of the same mass as the raw material.

Comparative example 3: the difference between the comparative example and example 1 is that heparin sodium was replaced with the same mass of peach kernel extract as the starting material.

Comparative example 4: this comparative example differs from example 4 in that the azone was replaced by the same mass of borneol in the starting material.

Comparative example 5: this comparative example differs from example 7 in that polyvinyl alcohol was not added to the starting material.

Comparative example 6: this comparative example differs from example 7 in that:

s1, weighing 2kg of the bacterial cellulose prepared in preparation example 1, 0.8kg of polyvinyl alcohol and 1.6kg of the loading mesoporous nano-silica prepared in preparation example 7, mixing, placing in 10kg of water, mixing and stirring, performing ultrasonic dispersion for 2min under the condition of 20kHz, and then standing for 4min to obtain a mixture.

Comparative example 7: the difference between this example and example 7 is that sodium alginate is not added to the raw material when the mesoporous nano-silica is prepared.

Performance test

1. Composite efficacy performance test

The compounds were prepared by the preparation methods of examples 1 to 9 and comparative examples 1 to 7, respectively, and eye creams were prepared as follows: weighing 3g of the compound, 2g of sodium hyaluronate, 4g of glycerol, 0.15g of urea sac and 3g of propylene glycol, placing the mixture in 100g of water, heating to 80 ℃, stirring for 10min at the rotating speed of 700r/min, then preserving heat for 15min, and cooling to room temperature to obtain the finished product of eye cream.

Finding 160 volunteers with similar black eye degree, evenly dividing the volunteers into 16 groups of 10 persons, and respectively using the finished eye creams prepared in examples 1-9 and comparative examples 1-7; volunteers before, 30 days after and 60 days after use respectively score the conditions of black eye fading, whitening and fine line fading totally with a score of 100.

2. Composite permeability Performance test

Collecting 200g male rat, cutting neck of rat, removing abdominal hair with hair clipper, cutting abdominal skin, removing subcutaneous fat layer, blood vessel and residue, cleaning with normal saline, testing integrity, rinsing with normal saline, and placing in-10 deg.C refrigeratorFreezing and storing for later use; in vitro transdermal test was performed using a horizontal Franz diffusion device, with rat skin sandwiched between a delivery chamber and a receiving chamber, with the stratum corneum facing the delivery chamber and an effective permeation area of 1.14cm²Adding 4.5mL of the sample (the plant composition prepared in each example and comparative example) into the supply chamber, adding 4.5mL of Phosphate Buffered Saline (PBS) into the receiving chamber, keeping the liquid level of the supply chamber and the receiving chamber completely over the uppermost edge of the skin at a constant speed of 300r/min at a constant temperature of 32 ℃, continuously stirring, sucking 0.1mL of the solution in the receiving chamber as a test solution by a pipette at 1min and 3min, measuring the content of the water-soluble active substance by an ultraviolet spectrophotometer, repeating the transdermal test of each human sample 3 times, and calculating the cumulative transdermal quantity according to the following formula:

in the formula, Q: accumulating the permeation amount; s: an effective diffusion area; v: receiving a volume of liquid in the receiving chamber; ci: the solubility of the sample in the receiving solution from the 1 st to the last sampling; cn: the concentration of the sample in the receiving fluid at this time.

3. Detection of the UV resistance of the composite

QB/T2410-98 ultraviolet absorbance method, namely measuring method of UVB sunscreen skin care effect of sunscreen skin care product, is adopted to detect the sunscreen effect of the finished eye cream prepared in examples 1-9 and comparative examples 1-7.

Table 1 composite performance test meter

Combining examples 1-3 and examples 4-6 with table 1, it can be seen that the addition of borneol and azone to the starting materials of examples 4-6 resulted in a higher fraction of example 4 than example 1 compared to example 1; the penetration of example 4 was higher than that of example 1; the borneol and the azone are matched, so that the active ingredients in the compound can be promoted to penetrate through the stratum corneum and permeate into the dermis, the generation of melanin is better inhibited, the compound has good whitening effect and fine wrinkle fading effect, and the effects of whitening the compound, removing dark circles and delaying aging are improved.

By combining examples 4-6 and examples 7-9 and table 1, it can be seen that the fraction of the raw material of examples 7-9, which is added with the azone modified bacterial cellulose, the polyvinyl alcohol and the loading mesoporous nano-silica, is higher than that of examples 4-6 in example 7; the penetration of example 7 was higher than that of example 4; the absorbance A value of example 7 is higher than that of example 4; the loaded mesoporous nano silicon dioxide, the azone modified bacterial cellulose and the polyvinyl alcohol are matched, so that the active ingredients in the mesoporous nano silicon dioxide can be slowly released, the compound has the effect of acting on the dermis of the skin for a long time, and the phenomenon that the active ingredients are lost due to skin metabolism to influence the effect of the compound on inhibiting melanin generation is avoided; and the bacterial cellulose and the carrier mesoporous nano-silica are matched and can be connected to form a compact net structure, so that ultraviolet rays in the external environment are isolated, and the skin melanin is prevented from being deposited in a large amount due to the irradiation of the ultraviolet rays, so that the effects of whitening the compound, removing dark circles and delaying aging are improved.

Combining examples 1-3 and comparative examples 1-3 and combining table 1, it can be seen that, in the raw material of comparative example 1, the ginseng extract was replaced with the same mass of the scutellaria baicalensis extract, the comparative example 1 was lower in score than example 1, the permeation amount of comparative example 1 was lower in score than example 1, and the absorbance a of comparative example 1 was lower than the absorbance a of example 1; the combination of the ginseng extract and the scutellaria extract is proved, the black eye is fundamentally removed by inhibiting the formation of melanin, and the whitening and wrinkle-fading effects are good.

Comparative example 2 in which the ginseng extract was replaced with the same mass of the angelica extract as the raw material, comparative example 2 was lower in score than example 1, comparative example 2 was lower in permeation amount than example 1, and comparative example 2 was lower in absorbance a than example 1; the combination of the ginseng extract, the peach kernel extract and the angelica extract can promote skin to absorb phloretin and other functional small molecules in ginseng, so that active ingredients penetrate into the muscle bottom, the secretion of melanin is inhibited, and the effects of whitening and fading fine wrinkles are achieved.

Comparative example 3 in which heparin sodium was replaced with the same mass of peach kernel extract as the raw material, comparative example 3 was lower in score than example 1, comparative example 3 was lower in permeation amount than example 1, and comparative example 3 was lower in absorbance a than example 1; the peach kernel extract, the angelica extract and the heparin sodium are matched, so that the blood circulation of the skin can be promoted, the metabolism of the skin is increased, the melanin pigmentation and the melanin granules on the basal layer are removed, and the effects of whitening and fading fine wrinkles are achieved.

Combining examples 4-6 and comparative example 4 and table 1, it can be seen that, replacing azone with an equivalent mass of borneol in the comparative example 4 starting material, the comparative example 4 score is lower than the example 4 score, the permeation of comparative example 4 is lower than the example 4, and the absorbance a of comparative example 4 is lower than the absorbance a of example 4; the borneol and the azone are matched, so that the absorption of the effective components in the compound by the skin can be effectively promoted, and the absorption amount is increased along with the prolonging of the time.

Combining examples 7-9 and comparative examples 5-7 and table 1, it can be seen that the raw material of comparative example 5 without polyvinyl alcohol added has a lower score for comparative example 5 than example 7, a lower permeation amount for comparative example 5 than example 7, and a lower absorbance a for comparative example 5 than example 7; the material-carrying mesoporous nano silicon dioxide is adhered to the surface of the azone modified bacterial cellulose by the polyvinyl alcohol, so that the effects of whitening, removing dark circles and fading fine lines of the compound can be improved; and the compound has good ultraviolet resistance.

Comparative example 6 the bacterial cellulose in the raw material was not modified with azone, and compared to example 7, the comparative example 6 was lower in score than example 7, the permeation amount of comparative example 6 was lower in permeation amount than example 7, and the absorbance a of comparative example 6 was lower in absorbance a than example 7; the result shows that the bacterial cellulose modified by the azone can enable the baicalin in the mesoporous nano silicon dioxide to quickly permeate into the dermis layer of the skin, so that the effect of long-acting inhibition of melanin generation is realized.

Comparative example 7 in the preparation of the loading mesoporous nano silica, no sodium alginate is added, compared with example 1, the fraction of comparative example 7 is lower than that of example 7, the permeation amount of comparative example 7 is lower than that of example 7, and the absorbance A of comparative example 7 is lower than that of example 7; the sodium alginate and the baicalin are matched with the mesoporous nano silicon dioxide, so that a large amount of baicalin can be positioned in pores of the nano mesoporous silicon dioxide, and the effect of long-acting inhibition of melanin generation can be realized along with the slow release of the baicalin.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. The compound with the effects of whitening, removing dark circles and delaying aging is characterized by being prepared from the following raw materials in parts by weight: 15-25 parts of ginseng extract, 10-15 parts of peach kernel extract, 10-15 parts of angelica extract, 4-10 parts of caffeine, 8-16 parts of astragalus extract and 5-10 parts of heparin sodium.

2. The compound with effects of whitening, removing dark circles and delaying senescence according to claim 1, which is characterized in that: the compound also comprises the following raw materials in parts by weight: 1-2 parts of borneol and 0.5-1.5 parts of azone.

3. The compound with effects of whitening, removing dark circles and delaying aging according to claim 2, wherein the borneol is natural borneol.

4. The compound with the effects of whitening, removing dark circles and delaying senescence according to claim 2, further comprising the following raw materials in parts by weight: 1-3 parts of azone modified bacterial cellulose, 0.5-1 part of polyvinyl alcohol, 1-2 parts of loading mesoporous nano silicon dioxide and 8-14 parts of water; baicalin is loaded in pores of the material-loading mesoporous nano-silica.

5. The compound with effects of whitening, removing dark circles and delaying aging according to claim 4, wherein the azone modified bacterial cellulose is prepared by the following method: weighing 1-3 parts of bacterial cellulose, soaking in 10-15 parts of azone for 1-3min, and air-drying at 40 ℃ for 1-3min to obtain the modified bacterial cellulose.

6. The compound with effects of whitening, removing dark circles and delaying senescence according to claim 4, wherein the loading mesoporous nano-silica is prepared by the following method:

7. The composition with effects of whitening, removing dark circles and delaying senescence according to claim 6, wherein the composition is stirred at a rotation speed of 600-800r/min for 2-5min before ultrasonic dispersion.

8. The preparation method of the compound with the effects of whitening, removing dark circles and delaying aging as claimed in any one of claims 4-7, is characterized by comprising the following steps: