CN108969444A - One kind removing black eye, crease-resistant Firm anti-age corrective eye treatment cream and preparation method thereof - Google Patents
One kind removing black eye, crease-resistant Firm anti-age corrective eye treatment cream and preparation method thereof Download PDFInfo
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- CN108969444A CN108969444A CN201811093713.1A CN201811093713A CN108969444A CN 108969444 A CN108969444 A CN 108969444A CN 201811093713 A CN201811093713 A CN 201811093713A CN 108969444 A CN108969444 A CN 108969444A
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- treatment cream
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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Abstract
The invention discloses one kind to remove black eye, crease-resistant Firm anti-age corrective eye treatment cream and preparation method thereof.The anti-age corrective eye treatment cream includes following components: glycerol, palmitinic acid, saualane, cetostearyl alcohol, methyl gluceth -10, lecithin, caprylic/capric triglyceride, liposome containing essence oil nanometer, Coffea arabica seed extract, Rhizoma Zingiberis zerumbet extract, Portugal leaf extract, undecylenoyl phenylalanine, acetyl chitosamine, Ba 2672, plants fruits and seeds superfine powder, dextran sulfate sodium, polypropylene acyl group dimethyl Taurine ammonium, Phenoxyethanol, Sensiva SC50, surplus is deionized water.There is significant cooperative gain effect between each ingredient, to Vitamin K, calm down microgroove, eliminate eye pouch and have a significant effect, and relative to existing eye cream, the present invention is more salubrious easily to be absorbed, it will not cause to bear to eye skin, not will form eye fat granule.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to one kind goes black eye, crease-resistant Firm anti-age corrective eye treatment cream and its system
Preparation Method.
Background technique
Eyes are the positions for revealing the age earliest on the face.It since eye skin is the most thin skin of human body, while being living again
Move most frequent position, it is easier to by extraneous injury.Eye sub-surface porosity connective tissue is abundant, soft and flexible,
In the fibre structure of loose connective tissue, it is dispersed with capillary and nerve endings extremely abundant, the pipe of these capillaries
Wall is very thin, and has certain permeability.Loose connective tissue is easy to congested, ponding and forms hemotoncus or oedema.
Eye is subcutaneously distributed almost without sebaceous glands or sweat gland, and the thin thin skin skin around eyes is very easy to drying, lacks moisture.Cause
Lack sebaceous glands and sweat gland for eye part skin, the not natural moist ability of periocualr skin, the grease that can be supplied is opposite will less very
It is more, cause eye part skin to be easy to aging.The skin sensitivity of circumference of eyes is fragile, and capilary is extremely fine, it is easy to generate wrinkle
Line, black eye, eye pouch.
Black eye, eye microgroove and eye pouch seriously affect the makings and appearance of a people, are easy to make one to present a weathered appearance thin and pallid
It is worried.The formation of three is a kind of chain reaction, due to the growth at age, dry thinning, the collagen egg of the epidermal tissue of eye part skin
White and elastin laminin is gradually lost, and the dusting cover reticular structure being interwoven originally by collagenous fibres and elastomer is destroyed,
It just will appear the different wrinkle of thickness；Eye sluggish metabolism, poor blood circulation, capillary blocking.It is anti-to cause inflammation
Should and pigmentation, form black eye；The further aging of eye skin, when aging to a certain extent, just support incessantly siltation
Fat causes eye skin plumpness prominent, eye pouch there have been.
Eye cream, one of skin type cosmetic product are that have moist function for protecting around eyes than relatively thin skin
Effect, has certain effect to eye pouch, black eye, crow's feet, dry line, microgroove etc..Eye cream product has much currently on the market, but
It is generally existing poor permeability, is not easy to absorb, the problems such as using effect is unobvious, some products even can causes grease grain, mistake
Some adverse reactions such as quick, therefore, it is necessary to one kind can safely and effectively solve the problems, such as the beauty skin care product of eye part skin, with
Meets the needs of market.
Summary of the invention
The object of the present invention is to provide one kind to remove black eye, crease-resistant Firm anti-age corrective eye treatment cream and preparation method thereof.Described repairs
Eyeshield frost, which contains, nourishes ingredient there are many natural, can effectively penetrate into eye part skin tissue, eliminate melanin, Vitamin K, and
Dermal collagen and fibrocyte are activated, the reconstruct of collagen elastic fibers is promoted, to realize depth Firm, lift crease-resistant and hold
Continuous elasticity of renewing one's youth.
The present invention is achieved by the following technical programs:
One kind going black eye, crease-resistant Firm anti-age corrective eye treatment cream, by mass percentage, including following components: glycerol 2~8%,
Palmitinic acid 1~3%, saualane 1~3%, cetostearyl alcohol 1~4%, methyl gluceth -10 1~3%, lecithin 0.5
~4%, caprylic/capric triglyceride 1~5%, liposome containing essence oil nanometer 6~12%, Coffea arabica seed extract 0.5~
4%, Rhizoma Zingiberis zerumbet extract 0.5~4%, Portugal leaf extract 0.5~4%, undecylenoyl phenylalanine 1~4%, acetyl
Chitosamine 1~4%, Ba 2672 1~4%, plants fruits and seeds superfine powder 3~7%, dextran sulfate sodium 1~6%, poly- third
Enoyl- dimethyl Taurine ammonium 0.2~1%, Phenoxyethanol 0.01~0.2%, Sensiva SC50 0.01~0.2%, surplus
For deionized water.
It is preferred that described goes black eye, crease-resistant Firm anti-age corrective eye treatment cream, by mass percentage, including following components: glycerol
4~6%, palmitinic acid 1~2%, saualane 1~2%, cetostearyl alcohol 1~3%, methyl gluceth -10 1~3%, ovum
Phosphatidase 1~3%, caprylic/capric triglyceride 2~4%, liposome containing essence oil nanometer 8~12%, Coffea arabica seed extract 1
~3%, Rhizoma Zingiberis zerumbet extract 1~3%, Portugal leaf extract 1~3%, undecylenoyl phenylalanine 2~3%, acetyl shell
Osamine 1~3%, Ba 2672 1~3%, plants fruits and seeds superfine powder 4~6%, dextran sulfate sodium 2~5%, polypropylene
Acyl group dimethyl Taurine ammonium 0.5~1%, Phenoxyethanol 0.05~0.15%, Sensiva SC50 0.05~0.15%, surplus
For deionized water.
It is further preferred that described goes black eye, crease-resistant Firm anti-age corrective eye treatment cream, by mass percentage, including following components: it is sweet
It is oil 5%, palmitinic acid 1.5%, saualane 2%, cetostearyl alcohol 3%, methyl gluceth -10 2%, lecithin 3%, pungent
Acid/Triglyceride DDD 4%, liposome containing essence oil nanometer 10%, Coffea arabica seed extract 3%, Rhizoma Zingiberis zerumbet extract 2%,
Portugal leaf extract 2%, undecylenoyl phenylalanine 3%, acetyl chitosamine 1.5%, Ba 2672 2%, plant fruit
Seed superfine powder 5%, dextran sulfate sodium 4%, polypropylene acyl group dimethyl Taurine ammonium 0.5%, Phenoxyethanol 0.05%, second
Base hexyl glycerol 0.15%, surplus is deionized water.
The plants fruits and seeds superfine powder is oenothera seed, Semen Vitis Amurensis, alfalfa seed and buckwheat seed with 1:(1~2):
(0.5~1): the mass ratio composition of (1~3).It is preferred that the plants fruits and seeds superfine powder is oenothera seed, Semen Vitis Amurensis, purple lucerne
Mu seed and buckwheat seed are formed with the mass ratio of 1:1:0.5:2.
The preparation of the plants fruits and seeds superfine powder is the following steps are included: by the oenothera seed, Semen Vitis Amurensis, purple of formula ratio
Alfalfa seed and buckwheat seed mix, and crush, obtain seed mixed-powder；Seed mixed-powder is added in airflow milling powder machine, into
Row airflow milling, the micro mist sufficiently ground is with air-flow by the gap of separation wheel, and what is do not ground sufficiently cannot then pass through,
Continue airflow milling, until the partial size of powder is 0.2~1 μm, collection obtains plants fruits and seeds superfine powder.
The mass percent of solid content is 20~30% in the liposome containing essence oil nanometer, and the formula group of solid content
At by mass percentage, including following components: permanent flower essential oil 5~10%, rock Rosa Damascana 5~10%, vitamin E 8~
16%, hydrogenated soy phosphatidyl choline 35~45%, cholesterol 5~15%, cupreol 5~15% and Tween-80 4~8%.
It is preferred that the mass percent of solid content is 20~30% in the liposome containing essence oil nanometer, and solid content
Formula composition by mass percentage, including following components: permanent flower essential oil 8%, rock Rosa Damascana 8%, vitamin E 14%,
Hydrogenated soy phosphatidyl choline 40%, cholesterol 12%, cupreol 12% and Tween-80 6%.
The preparation of the liposome containing essence oil nanometer the following steps are included:
(1) permanent flower essential oil, rock Rosa Damascana, vitamin E, hydrogenated soy phosphatidyl choline, cholesterol, β-paddy are measured by formula
Sterol is added in 40~60 DEG C of dehydrated alcohol, is sufficiently dissolved, is obtained oily phase；
(2) Tween-80 of formula ratio is added in the PBS buffer solution that temperature is 40~50 DEG C, is slowly added to, Bian Jia
Side stirring, is sufficiently mixed, and the solution that the mass percent of Tween-80 is 0.8~2.4% is made, obtains water phase；
(3) in the case where magnetic stirring apparatus is stirred continuously, water phase is injected into oily phase with syringe, is sufficiently mixed 0.5~1h,
Then at 28~32 DEG C, rotary evaporation under conditions of 0.1~1MPa removes ethyl alcohol, then vibrates aquation in 30~35 DEG C of water-baths
React 1~2h, obtain liposome suspension, using the partial size of syringe type filter adjustment liposome suspension to 100~
150nm is to get liposome containing essence oil nanometer.
In addition, the present invention also provides the preparation method for going black eye, crease-resistant Firm anti-age corrective eye treatment cream described in one kind, this method
The following steps are included:
(1) by the deionized water of formula ratio, glycerol, acetyl chitosamine, plants fruits and seeds superfine powder, dextran sulfate sodium,
Polypropylene acyl group dimethyl Taurine ammonium is added water phase pot, is heated to 70~75 DEG C, stirs evenly, obtain water phase；
(2) by the palmitinic acid of formula ratio, saualane, cetostearyl alcohol, methyl gluceth -10, lecithin, octanoic acid/
Triglyceride DDD is added oily phase pot, is heated to 70~75 DEG C, stirs evenly, obtain oily phase；
(3) will water phase be pumped into vacuum emulsifying machine in, open stirring and vacuum, 80~85 DEG C, vacuum degree be -0.06~-
Under conditions of 0.04MPa, speed of agitator are 60~80r/min, by oily mutually sucking mulser, mixed liquor are obtained, is then existed
10~15min of homogeneous under 2000~3000r/min；
(4) it after the completion of homogeneous, keeps vacuum degree and mixing speed constant, is cooled to 40~45 DEG C, be added and contain essence oil nanometer
Liposome, Coffea arabica seed extract, Rhizoma Zingiberis zerumbet extract, Portugal leaf extract, undecylenoyl phenylalanine, horse chestnut
Saponin(e, Phenoxyethanol and Sensiva SC50 continue to stir evenly, be cooled to room temperature, discharging, filling to get going black eye, anti-
Wrinkle Firm anti-age corrective eye treatment cream.
It is thin to can promote skin rich in substances such as neryl acetate, neryl butyrate, nerols for permanent flower essential oil in formula
Born of the same parents' regeneration, activates Skin Cell, promotes cutin interstitial and collagen regeneration, accelerates wound to repair speed, to microgroove is calmed down, tightly
Cause eye skin that there is apparent effect；Rock Rosa Damascana is rich in the substances such as α-firpene, borneol, acetic acid bornyl ester, laudanum alcohol,
Can unimpeded blood vessel, promote blood circulation, promote lympha toxin expelling, tissue detumescence, to desalination eye black eye, eliminate eye pouch have it is bright
Aobvious effect.The present invention compounds permanent flower essential oil and rock Rosa Damascana, is formed with being conducive to the nanometer that eye part skin absorbs
Liposome can be effectively absorbed by the skin through cuticula, and substantially increase the stability of essential oil, reduce the stimulation of essential oil
Property.A small amount of vitamin E is added in formula simultaneously, Skin Cell can be helped preferably to absorb essential oil nutritional ingredient, makes containing essence
Oily nano liposomes preferably play desalination eye black eye, calm down microgroove, eliminate the effect of eye pouch.
Inhibit to make in addition, Coffea arabica (COFFEA ARABICA) seed extract contained in formula has trypsase
With, can inhibit degradation of the trypsase to elastin laminin, to cortex elastic protein fiber have protective effect, fundamentally solve
Wrinkle Producing reason: the loss of collagen elastic fibers inhibits the generation of wrinkle to have apparent effect to microgroove is calmed down
Fruit.Rhizoma Zingiberis zerumbet (ZINGIBER ZERUMBET) extract has the function of improving eyesight nourishing the liver, and eyes is made to regain beautiful brilliance, bright eyes
It is kind to look at, and the diuresis that can dehumidify, activating blood circulation promote skin metabolism, activate skin microcirculation by vasodilator effect, from
And a large amount of rows that vein is detained and siltation is fatty is caused to be rushed down, deep layer melanin is excluded, helps to eliminate eye pouch and black eye.Portugal
(SYZYGIUM JAMBOS) leaf extract can balance skin pH value, restrain pore, repair impaired skin, and be melted into rich in antioxygen
Point, cuticula depths can be effectively infiltrated into, the generation of Mai Laning is prevented, prevents blackspot, color spot, eliminates black eye.Three's compounding
Use, by inhibiting the loss of collagen elastic fibers, activating blood circulation promotes skin metabolism, repair impaired skin with
And oxidation resistant effect, reach the compact eye skin of lifting, calms down microgroove, eliminates eye pouch and black-eyed purpose.
The undecylenoyl phenylalanine passes through melanin stimulating hormone receptor on competitive binding melanocyte
MC1-R makes melanocyte that cannot generate tyrosinase, to inhibit melanocyte activity, reduces the generation of melanin, can
Enhance Portugal leaf extract and eliminates black-eyed effect.Acetyl chitosamine can promote hyaluronic acid synthesis, enhance the hydration of skin
Ability has obvious effect to the elasticity for promoting eye skin, can enhance the effect that Coffea arabica seed extract calms down microgroove.Seven
Leaf tree saponin(e, which can promote blood circulation, improves eye circumference edema, can enhance the effect that Rhizoma Zingiberis zerumbet extract eliminates eye pouch.
Plants fruits and seeds superfine powder in formula is the mixed of oenothera seed, Semen Vitis Amurensis, alfalfa seed and buckwheat seed superfine powder
Object is closed, the smooth effect of eye cream can be improved, improves salubrious degree, prevents clogging of pores, prevent the formation of fat granule.
Anti-age corrective eye treatment cream appearance provided by the invention is fine and smooth lotion, and pH is 6.2~7.1, viscosity is 10000~
15000mpa.s, 45 DEG C 24 hours heat-resisting, changes after restoring room temperature without obvious character, and -18 DEG C 24 hours cold-resistant, after restoring room temperature
No obvious character variation.
Ingredient in inventive formulation is unless otherwise instructed commercial product.Wherein, Coffea arabica
(COFFEAARABICA) seed extract is purchased from U.S. Active Concepts company.Rhizoma Zingiberis zerumbet (ZINGIBER ZERUMBET)
Extract is purchased from Tianfeng Biological Science & Technology Co., Ltd., Xi'an.Portugal (SYZYGIUM JAMBOS) leaf extract is purchased from Xi'an Tianrui
Bioisystech Co., Ltd.No. CAS of undecylenoyl phenylalanine are as follows: 175357-18-3, purchased from the good rich biology that is full of in Xi'an
Science and Technology Ltd..No. CAS of acetyl chitosamine are as follows: 7512-17-6 is purchased from this Biotechnology Co., Ltd of Guangzhou bud.Seven
No. CAS of leaf tree saponin(e are as follows: 6805-41-0 is purchased from Hubei Ju Sheng Science and Technology Ltd..
Oenothera seed is purchased from Bozhou City An Bo pharmaceutcal corporation, Ltd；Semen Vitis Amurensis is purchased from the good boat medicine company Limited Liability of Bozhou City
Company；Alfalfa seed and buckwheat seed are purchased from Bozhou City benevalent hall Chinese medicine sale Co., Ltd.
Permanent flower essential oil, source area France, mentions commerce and trade Co., Ltd purchased from Beijing Ya Keye；Rock Rosa Damascana, source area
France mentions commerce and trade Co., Ltd purchased from purchased from Beijing Ya Keye；Vitamin E is purchased from Guangzhou Nuo Xin Biotechnology Co., Ltd.
Compared with prior art, the invention has the following advantages:
(1) anti-age corrective eye treatment cream proportion science of the present invention, Coffea arabica seed extract, Rhizoma Zingiberis zerumbet extract, the Portugal leaf contained
Extract, undecylenoyl phenylalanine, acetyl chitosamine, Ba 2672, liposome containing essence oil nanometer, plants fruits and seeds are super
The nutritional ingredients such as fine powder have significant cooperative gain effect each other, to Vitamin K, calm down microgroove, eliminate eye pouch have
Apparent effect, and relative to existing eye cream, the present invention is more salubrious easily to be absorbed, it will not cause to bear to eye skin,
Eye fat granule is not will form.
(2) present invention optimizes the formulation composition of anti-age corrective eye treatment cream, by inhibiting the loss of collagen elastic fibers,
Activating blood circulation, promote skin metabolism, promote row rushes down vein be detained and siltation fat, exclude deep layer melanin, repair by
Skin is damaged, moisturizing is releived and oxidation resistant effect, reaches the compact eye skin of lifting, calms down microgroove, eliminates eye pouch and black eye
The purpose of circle.
(3) anti-age corrective eye treatment cream of the present invention is low to skin irritation, will not cause allergic reaction, property mildly safety, and infiltration
Property is good, is easy to absorb, clearly not sticky using rear skin；And preparation process is simple, and condition is controllable, process stabilizing.
Specific embodiment
The following examples are further illustrations of the invention, rather than limiting the invention.
1 liposome preparation containing essence oil nanometer of embodiment
The mass percent of solid content is 25%, specifically, the formula of solid content in 1 liposome containing essence oil nanometer of embodiment
It forms by mass percentage, including component shown in following table:
It is calculated by 25g containing solid content in 100g liposome containing essence oil nanometer,
The preparation method of A group:
(1) it is solid that the permanent flower essential oil of 2g, 2g rock Rosa Damascana, 3.5g vitamin E, 10g hydrogenated soy phosphatidyl choline, 3g gallbladder are weighed
Alcohol, 3g cupreol are added in 50 DEG C of dehydrated alcohol, are sufficiently dissolved, are obtained oily phase；
(2) 1.5g Tween-80 is added in the PBS buffer solution that temperature is 50 DEG C, is slowly added to, it is stirring while adding,
It is sufficiently mixed, the solution that the mass percent of Tween-80 is 1.5% is made, obtains water phase；
(3) in the case where magnetic stirring apparatus is stirred continuously, water phase is injected into oily phase with syringe, is sufficiently mixed 1h, then
At 30 DEG C, rotary evaporation under conditions of 0.8MPa removes ethyl alcohol, then hydration reaction 2h is vibrated in 32 DEG C of water-baths, obtains liposome
Suspension, using the partial size of syringe type filter adjustment liposome suspension to 100~150nm to get rouge containing essence oil nanometer
Plastid.
B, the preparation method of C group refers to A group.
The preparation of 2 plants fruits and seeds superfine powder of embodiment
The formula composition of 2 plants fruits and seeds superfine powder of embodiment are as follows: based on 100g plants fruits and seeds superfine powder, including shown in following table
Component:
| Component | A group | B group | C group |
| Oenothera seed | 22.2g | 16.7g | 18.2g |
| Semen Vitis Amurensis | 22.2g | 16.7g | 36.4g |
| Alfalfa seed | 11.2g | 16.7g | 9.0g |
| Buckwheat seed | 44.4g | 49.9g | 36.4g |
Preparation method: the oenothera seed of formula ratio, Semen Vitis Amurensis, alfalfa seed and buckwheat seed mix, crushes, obtains
Seed mixed-powder；Will seed mixed-powder be added airflow milling powder machine in, carry out airflow milling, the micro mist sufficiently ground with
Air-flow is by the gap of separation wheel, and what is do not ground sufficiently cannot then pass through, and continue airflow milling, until the partial size of powder
It is 0.2~1 μm, collection obtains plants fruits and seeds superfine powder.
The preparation of 3 anti-age corrective eye treatment cream of embodiment
The formula composition of 3 anti-age corrective eye treatment cream of embodiment are as follows: by mass percentage, including component shown in following table:
Preparation method:
(1) by the deionized water of formula ratio, glycerol, acetyl chitosamine, plants fruits and seeds superfine powder, dextran sulfate sodium,
Polypropylene acyl group dimethyl Taurine ammonium is added water phase pot, is heated to 75 DEG C, stirs evenly, obtain water phase；
(2) by the palmitinic acid of formula ratio, saualane, cetostearyl alcohol, methyl gluceth -10, lecithin, octanoic acid/
Triglyceride DDD is added oily phase pot, is heated to 75 DEG C, stirs evenly, obtain oily phase；
(3) water phase is pumped into vacuum emulsifying machine, opens stirring and vacuum, be -0.04MPa, stir in 80 DEG C, vacuum degree
Under conditions of revolving speed is 80r/min, by oily mutually sucking mulser, mixed liquor is obtained, then the homogeneous at 3000r/min
12min；
(4) it after the completion of homogeneous, keeps vacuum degree and mixing speed constant, is cooled to 45 DEG C, lipid containing essence oil nanometer is added
Body, Coffea arabica seed extract, Rhizoma Zingiberis zerumbet extract, Portugal leaf extract, undecylenoyl phenylalanine, horse chestnut soap
Glycosides, Phenoxyethanol and Sensiva SC50 continue to stir evenly, be cooled to room temperature, discharging, filling to get anti-age corrective eye treatment cream.
The preparation of 1 anti-age corrective eye treatment cream of comparative example
The formula composition of 1 anti-age corrective eye treatment cream of comparative example are as follows: by mass percentage, including component shown in following table:
Preparation method reference implementation example 3.
Test example one, anti-age corrective eye treatment cream security test
Tested crowd's number: 110 people, women, the age 30-60 years old, subjects skin's health, no skin allergy history met
Tested aspiration inclusion criteria, is divided into 11 groups, and every group of 10 people average age 38 ± 2 years old, respectively test 1-11 group, wherein test
1-5 group is formulated eye cream made from 1-5 using embodiment 3, and test 6-11 group is formulated eye cream made from 6-11 using comparative example 1.
Application method: dipping eye cream small rice grain size with the third finger, first taps in side now, left hand is lightly by eye
Lower eyelid a bit, then does annular along inner eye corner, upper eyelid, eye tail, lower eyelid and gently massages toward drop-down, and generally 4-5 circle is left
It is right；Finally again with the third finger of two hands, gently corresponding eyes are clapped in place, and skin is allowed to fully absorb.
The result shows that: after smearing eye cream 8h, 12h made from the formula of the embodiment of the present invention 3 1-5 and comparative example 6-11, have no
The rubescent equal allergic reactions of eye part skin, illustrate the eye cream of product of the present invention be it is safe, without any bad phenomenon.
Test example two, anti-age corrective eye treatment cream go black eye effect assessment
Tested crowd's number: selection periocualr skin has the women trial volunteer of the obscure colour of skin, color spot, black eye problem
110, the age 25-60 years old, average age 35 ± 5 years old, it is divided into 11 groups, every group of 10 people, respectively test 1-5 group and comparison 1-6
Group, wherein test 1-5 group is formulated eye cream made from 1-5 using embodiment 3, and comparison 1-6 group is formulated 6-11 system using comparative example 1
The eye cream obtained.
Application method: after morning and evening face cleaning skin toner, taking tested eye cream appropriate, and point is applied to eye circumference, uniformly smears and is massaged into
It absorbs.Respectively before use, testing the melanin value of eye part skin after using 1 month, colour of skin L* value, colour of skin b* value is calculated
ITA °, wherein colour of skin L* value is bigger, indicates that the colour of skin is whiter；Colour of skin b* value is bigger, indicates that the colour of skin is more dark yellow；ITA ° of bigger, the table of value
Show that the colour of skin is whiter.As a result it see the table below shown in 1.
1 anti-age corrective eye treatment cream of table removes black-eyed effect assessment
The results show that trial volunteer uses embodiment 3 to be formulated eye cream made from 1-5, the level of eye melanin respectively
It being substantially reduced, colour of skin L* value and ITA ° of value increase, and effect is substantially better than using eye cream made from the formula of comparative example 1 6-11, and with
The using effect of eye cream made from the formula of embodiment 31 is best, shows that anti-age corrective eye treatment cream provided by the invention is black with preferably removing
Eyelet promotes the effect of eye skin brilliant white degree.And during the test, the trial volunteer in addition to 6 groups of comparison has 4 eyes
Portion occurs outside a small amount of fat granule, remaining each group trial volunteer does not occur fat granule.
By comparative example 1 it is found that lacking liposome containing essence oil nanometer in formula, to melanin content is reduced, it is bright to promote skin
It is certain to show that liposome containing essence oil nanometer has effects that improvement black eye symptom for the decreased effectiveness of whiteness；It can by comparative example 2-4
Know, lacks Rhizoma Zingiberis zerumbet extract and Portugal leaf extract simultaneously in formula, or lack Coffea arabica seed extract and Portugal simultaneously
Leaf extract, or lack Coffea arabica seed extract and Rhizoma Zingiberis zerumbet extract simultaneously, to melanin content is reduced, it is bright to promote skin
The decreased effectiveness of whiteness shows Coffea arabica seed extract, Portugal leaf extract and Rhizoma Zingiberis zerumbet extract three compounding, to improvement
Black eye has apparent synergistic effect；By comparative example 5 it is found that directly permanent flower essential oil and rock Rosa Damascana are directly added into and are matched
Fang Zhong, rather than in the form of liposome, to melanin content is reduced, the decreased effectiveness of skin brilliant white degree is promoted, is shown containing essence
Oily nano liposomes are more advantageous to skin absorption, more preferably remove black eye effect to play；By comparative example 6 it is found that formula
The middle plants fruits and seeds superfine powder that lacks is little to the influential effect for improving black eye symptom, and eye cream obtained still has preferable reduction
Melanin content promotes the effect of skin brilliant white degree, but influences the appearance situation of trial volunteer's eye fat granule, shows plant
Fruit seed superfine powder helps to promote the smooth degree of eye cream, can effectively defend occur the bad anti-of fat granule in eye cream use process
It answers.
Test example three, anti-age corrective eye treatment cream go eye pouch effect assessment
Tested crowd's number: selection has trial volunteer 220 of long-term eye pouch problem, the age 40-60 years old, is divided into 11
Group, every group of 20 people, respectively test 1-5 group and comparison 1-6 group, wherein test 1-5 group is formulated made from 1-5 using embodiment 3
Eye cream, comparison 1-6 group are formulated eye cream made from 6-11 using comparative example 1.
Application method: after morning and evening face cleaning skin toner, taking tested eye cream appropriate, and point is applied to eye circumference, uniformly smears and is massaged into
It absorbs.Respectively before use, measuring eye pouch volume after using 2 months.Eye pouch stereometry is known as Fringe using one
The technology of Projection carries out, and the 3D rendering of survey region obtains by a FaceScanner and uses Optocat software
Processing (Breuckman, Germany-EoTech, France).
Curative effect determinate standard:
Effective: eye pouch volume reduces 35% or more；
Effective: eye pouch volume reduces 30-35%；
Improve: eye pouch volume reduces 0-30%；
Invalid: eye pouch volume does not change or increases.
As a result it see the table below shown in 2.
The effect assessment of 2 anti-age corrective eye treatment cream of table removal eye pouch
The results show that trial volunteer uses embodiment 3 to be formulated eye cream made from 1-5 respectively, eye pouch volume is significantly reduced,
Obvious effective rate is efficient up to 45% or more up to 20% or more；Inefficiency is 0%；Effect, which is substantially better than, is formulated 6-11 using comparative example 1
Eye cream obtained, and it is best with the using effect of eye cream made from the formula of embodiment 31, show anti-age corrective eye treatment cream provided by the invention
With preferable removal eye pouch effect.And during the test, the trial volunteer in addition to 6 groups of comparison has 7 eyes to occur
Outside a small amount of fat granule, remaining each group trial volunteer does not occur fat granule.
Test example four, anti-age corrective eye treatment cream increase skin elasticity, anti-wrinkle effect evaluation
Tested crowd's number: selection women trial volunteer 110, the age 35-60 years old, all trial volunteer's skins were strong
Health, no skin allergy history, meets subject enrollment standard, is divided into 11 groups, every group of 10 people, respectively test 1-5 group and comparison 1-6
Group, wherein test 1-5 group is formulated eye cream made from 1-5 using embodiment 3, and comparison 1-6 group is formulated 6-11 system using comparative example 1
The eye cream obtained.
Application method: after morning and evening face cleaning skin toner, taking tested eye cream appropriate, and point is applied to eye circumference, uniformly smears and is massaged into
It absorbs.The skin elasticity CotometerMPA580 master manufactured using German Courage+Khazaka company (German CK company)
Machine, used probe are Reviscometer RV600 elastic fibrous tissue test probes, survey five times and are averaged.Test section
Domain: eye circumference skin.The blank value (R2, R5, R7) of 30min after being tested region clean is first measured, then provides that subject is daily
Sooner or later adhere to that, using above-mentioned trial target, test zone skin elasticity index R2, R5, R7 value (was tested after testing 0 week, 4 weeks respectively
It is 450mbar that negative pressure is constant in journey).
Index explanation: for skin elasticity index R2, R5, R7 closer to 1, the elasticity of skin is better.
R2=Ua/Uf；R5=Ur/Ue；R7=Ur/Uf.
Uf --- skin maximum tension amount.
Ue --- after constant negative pressure is added on skin, the amount of tension of skin, positioning elastic part amount of tension at 0.1 second.
Ur --- after cancelling negative pressure, skin will restore to the original state rapidly state, equally be divided into elastic portion score value Ur, that is, cancel negative
Pressure is after 0.1 second, the recovery value and visco-elastic portions value or plastic value of skin.
Ua --- from cancellation negative pressure to the recovery value of skin when follow-on test skin surface adds negative pressure again next time.
As a result it see the table below shown in 3.
3 anti-age corrective eye treatment cream of table increases skin elasticity, anti-wrinkle effect evaluation
The results show that trial volunteer use respectively embodiment 3 be formulated 1-5 made from after eye cream 4 weeks R2, R5, R7 on
Rise obvious, and R2, R5, R7 value level off to 1, and the skin elasticity index of subject has very big promotion, hence it is evident that better than using pair
Ratio 1 is formulated eye cream made from 6-11, and best with the using effect of eye cream made from the formula of embodiment 31, it can be seen that, this
Invention anti-age corrective eye treatment cream, which has, to be increased skin elasticity, calms down microgroove, anti-aging function.And during the test, in addition to comparison 6
The trial volunteer of group has 3 eyes to occur outside a small amount of fat granule, remaining each group trial volunteer does not occur fat granule.
The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
It also should be regarded as protection scope of the present invention into retouching.
Claims (9)
1. one kind goes black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that by mass percentage, including following components: it is sweet
Oil 2~8%, palmitinic acid 1~3%, saualane 1~3%, cetostearyl alcohol 1~4%, methyl gluceth -10 1~3%,
Lecithin 0.5~4%, caprylic/capric triglyceride 1~5%, liposome containing essence oil nanometer 6~12%, Coffea arabica seed extract
Object 0.5~4%, Rhizoma Zingiberis zerumbet extract 0.5~4%, Portugal leaf extract 0.5~4%, undecylenoyl phenylalanine 1~
4%, acetyl chitosamine 1~4%, Ba 2672 1~4%, plants fruits and seeds superfine powder 3~7%, dextran sulfate sodium 1~
6%, polypropylene acyl group dimethyl Taurine ammonium 0.2~1%, Phenoxyethanol 0.01~0.2%, Sensiva SC50 0.01~
0.2%, surplus is deionized water.
2. according to claim 1 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that by mass percentage,
Including following components: glycerol 4~6%, palmitinic acid 1~2%, saualane 1~2%, cetostearyl alcohol 1~3%, methyl alcohol
Polyethers -10 1~3%, lecithin 1~3%, caprylic/capric triglyceride 2~4%, liposome containing essence oil nanometer 8~12%,
Coffea arabica seed extract 1~3%, Rhizoma Zingiberis zerumbet extract 1~3%, Portugal leaf extract 1~3%, undecylenoyl phenylpropyl alcohol
Propylhomoserin 2~3%, acetyl chitosamine 1~3%, Ba 2672 1~3%, plants fruits and seeds superfine powder 4~6%, glucan sulfuric acid
Ester sodium 2~5%, polypropylene acyl group dimethyl Taurine ammonium 0.5~1%, Phenoxyethanol 0.05~0.15%, Sensiva SC50
0.05~0.15%, surplus is deionized water.
3. according to claim 1 or 2 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that the plant fruit
Seed superfine powder is oenothera seed, Semen Vitis Amurensis, alfalfa seed and buckwheat seed with 1:(1~2): (0.5~1): the quality of (1~3)
Than composition.
4. according to claim 3 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that the plants fruits and seeds
Superfine powder is that oenothera seed, Semen Vitis Amurensis, alfalfa seed and buckwheat seed are formed with the mass ratio of 1:1:0.5:2.
5. according to claim 3 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that the plants fruits and seeds
The preparation of superfine powder mixes, powder the following steps are included: by the oenothera seed of formula ratio, Semen Vitis Amurensis, alfalfa seed and buckwheat seed
It is broken, obtain seed mixed-powder；Seed mixed-powder is added in airflow milling powder machine, airflow milling is carried out, is sufficiently ground
Micro mist with air-flow by the gap of separation wheel, and what is do not ground sufficiently cannot then pass through, and continue airflow milling, until powder
The partial size of body is 0.2~1 μm, and collection obtains plants fruits and seeds superfine powder.
6. according to claim 1 or 2 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that described contains essential oil
The mass percent of solid content is 20~30% in nano liposomes, and the formula composition of solid content is by mass percentage, packet
Include following components: permanent flower essential oil 5~10%, rock Rosa Damascana 5~10%, vitamin E 8~16%, hydrogenated soy phosphatidyl choline
35~45%, cholesterol 5~15%, cupreol 5~15% and Tween-80 4~8%.
7. according to claim 6 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that described to be received containing essential oil
The mass percent of solid content is 20~30% in the plastid of Mizhi, and the formula composition of solid content is by mass percentage, including
Following components: permanent flower essential oil 8%, rock Rosa Damascana 8%, vitamin E 14%, hydrogenated soy phosphatidyl choline 40%, cholesterol
12%, cupreol 12% and Tween-80 6%.
8. according to claim 6 go black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that described to be received containing essential oil
The preparation of Mizhi plastid the following steps are included:
(1) permanent flower essential oil, rock Rosa Damascana, vitamin E, hydrogenated soy phosphatidyl choline, cholesterol, cupreol are measured by formula
It is added in 40~60 DEG C of dehydrated alcohol, sufficiently dissolves, obtain oily phase；
(2) Tween-80 of formula ratio is added in the PBS buffer solution that temperature is 40~50 DEG C, is slowly added to, side edged stirs
It mixes, is sufficiently mixed, the solution that the mass percent of Tween-80 is 0.8~2.4% is made, obtains water phase；
(3) in the case where magnetic stirring apparatus is stirred continuously, water phase is injected into oily phase with syringe, is sufficiently mixed 0.5~1h, then
At 28~32 DEG C, rotary evaporation under conditions of 0.1~1MPa removes ethyl alcohol, then hydration reaction 1 is vibrated in 30~35 DEG C of water-baths
~2h, obtains liposome suspension, using syringe type filter adjustment liposome suspension partial size to 100~150nm to get
Liposome containing essence oil nanometer.
9. a kind of prepare the method described in claim 1 for going black eye, crease-resistant Firm anti-age corrective eye treatment cream, which is characterized in that including
Following steps:
(1) by the deionized water of formula ratio, glycerol, acetyl chitosamine, plants fruits and seeds superfine powder, dextran sulfate sodium, poly- third
Enoyl- dimethyl Taurine ammonium is added water phase pot, is heated to 70~75 DEG C, stirs evenly, obtain water phase；
(2) by the palmitinic acid of formula ratio, saualane, cetostearyl alcohol, methyl gluceth -10, lecithin, caprylic/capric
Triglycerides is added oily phase pot, is heated to 70~75 DEG C, stirs evenly, obtain oily phase；
(3) will water phase be pumped into vacuum emulsifying machine in, open stirring and vacuum, 80~85 DEG C, vacuum degree be -0.06~-
Under conditions of 0.04MPa, speed of agitator are 60~80r/min, by oily mutually sucking mulser, mixed liquor are obtained, is then existed
10~15min of homogeneous under 2000~3000r/min；
(4) it after the completion of homogeneous, keeps vacuum degree and mixing speed constant, is cooled to 40~45 DEG C, lipid containing essence oil nanometer is added
Body, Coffea arabica seed extract, Rhizoma Zingiberis zerumbet extract, Portugal leaf extract, undecylenoyl phenylalanine, horse chestnut soap
Glycosides, Phenoxyethanol and Sensiva SC50 continue to stir evenly, be cooled to room temperature, discharging, filling to get going black eye, crease-resistant
Firm anti-age corrective eye treatment cream.
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| CN111991286A (en) * | 2020-08-20 | 2020-11-27 | 上海致新生物科技有限公司 | Eye cream composition for fading fine wrinkles and preparation method thereof |
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