CN114209640B - Anti-aging skin care product composition and preparation method thereof - Google Patents
Anti-aging skin care product composition and preparation method thereof Download PDFInfo
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- CN114209640B CN114209640B CN202210104699.0A CN202210104699A CN114209640B CN 114209640 B CN114209640 B CN 114209640B CN 202210104699 A CN202210104699 A CN 202210104699A CN 114209640 B CN114209640 B CN 114209640B
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- ginger
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- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 240000000451 Zingiber zerumbet Species 0.000 claims abstract description 77
- 235000014687 Zingiber zerumbet Nutrition 0.000 claims abstract description 77
- VDFOMVRWDSKWSL-UHFFFAOYSA-N Zerumbone Natural products CC1=C2CC(C)(C)C=C2C(=O)C(=CCC1)C VDFOMVRWDSKWSL-UHFFFAOYSA-N 0.000 claims abstract description 35
- GIHNTRQPEMKFKO-SKTNYSRSSA-N zerumbone Chemical compound C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1 GIHNTRQPEMKFKO-SKTNYSRSSA-N 0.000 claims abstract description 35
- GIHNTRQPEMKFKO-UHFFFAOYSA-N zurembone Natural products CC1=CCC(C)(C)C=CC(=O)C(C)=CCC1 GIHNTRQPEMKFKO-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229940002508 ginger extract Drugs 0.000 claims abstract description 26
- 150000002576 ketones Chemical class 0.000 claims abstract description 23
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 19
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 19
- 229960003237 betaine Drugs 0.000 claims abstract description 19
- 239000008169 grapeseed oil Substances 0.000 claims abstract description 19
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 18
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 18
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 18
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 17
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 17
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 17
- 239000011648 beta-carotene Substances 0.000 claims abstract description 17
- 229960002747 betacarotene Drugs 0.000 claims abstract description 17
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 239000011159 matrix material Substances 0.000 claims description 22
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 20
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 20
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 20
- FLIACVVOZYBSBS-UHFFFAOYSA-N Methyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC FLIACVVOZYBSBS-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
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- 238000002156 mixing Methods 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 11
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 10
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 10
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- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
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- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 4
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 4
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- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Biotechnology (AREA)
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- Microbiology (AREA)
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- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an anti-aging skin care product composition and a preparation method thereof, and relates to the field of skin care products. The anti-aging skin care product composition is prepared from the following raw materials in parts by weight: 0.2-0.5 part of zerumbet ginger extract containing high-concentration zerumbet ginger ketone, 0.1-0.3 part of betaine, 0.01-0.05 part of grape seed oil, 0.005-0.01 part of beta-carotene and 0.005-0.01 part of tocopheryl acetate; wherein, the zerumbone has a structure shown in formula I:the multi-component comprehensive effect of the zingiber zerumbet extract, betaine, beta-carotene, grape seed oil and tocopheryl acetate containing high-concentration zerumbet can achieve the purposes of improving tension, causing skin and smoothing fine wrinkles by inhibiting the loss of collagen elastic fiber, repairing damaged skin and resisting oxidation.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an anti-aging skin care product composition and a preparation method thereof.
Background
With the improvement of the economic level and the abundance of material life of people, the demands of people for maintaining the image and the spirit and the appearance of the people are increasing, and skin care products (skin protection products) are going to common families nowadays.
Skin aging is actually the aging injury of skin function, so that the protection capability, regulation capability and the like of the skin on the organism are reduced, and further the change of appearance finishing conditions such as skin color, luster, morphology, texture and the like, which are caused by the fact that the skin cannot adapt to the change of internal and external environments, is caused.
Endogenous aging and exogenous aging are two major "murders" of skin aging. The endogenous aging refers to natural aging of skin with aging, and the aging is more obvious, and the skin is mainly characterized by fine wrinkles, reduced elasticity, loose skin and the like. Light aging caused by sun exposure in exogenous aging is a major cause, and is manifested by wrinkles, skin sagging, rough, yellowish or sallowness skin discoloration, telangiectasia, formation of pigment spots, and the like.
Endogenous aging is objectively present and unavoidable, and although there is currently no way to make aging reversible, it can delay the trace of aging left on the skin. Exogenous aging can be controlled and regulated, and the skin aging-resistant skin care product is used for improving skin immunity from inside to outside while helping skin to resist oxidation and repairing daily skin injury. However, the existing anti-aging skin care products still have poor anti-aging effect, and development of a skin care product with better anti-aging effect is necessary.
Disclosure of Invention
The invention provides an anti-aging skin care product composition which can inhibit biosynthesis of aging proteins and radically delay skin aging.
The invention provides an anti-aging skin care product composition which is prepared from the following raw materials in parts by weight: 0.2-0.5 part of zerumbet ginger extract containing high-concentration zerumbet ginger ketone, 0.1-0.3 part of betaine, 0.01-0.05 part of grape seed oil, 0.005-0.01 part of beta-carotene and 0.005-0.01 part of tocopheryl acetate;
wherein, the zerumbone has a structure shown in formula I:
further, the extract of zerumbet ginger containing high concentration of zerumbet ginger ketone is prepared by the steps of:
dissolving zerumbone in dimethyl sulfoxide to obtain zerumbone solution; mixing the zerumbone solution with hydrogenated castor oil, performing ultrasonic treatment, and incubating at 33 ℃ for 20-30 minutes to obtain zerumbone nano-microemulsion; adding the zerumbet nanometer microemulsion into the zerumbet ginger extract, and mixing to obtain the zerumbet ginger extract containing high concentration zerumbet ginger ketone.
Further, the mass ratio of the zerumbone to the dimethyl sulfoxide is 1 (80-120); preferably, the mass ratio of the zerumbone to the dimethyl sulfoxide is 1:100;
the mass ratio of the zerumbone solution to the hydrogenated castor oil is (1-5) 1; preferably, the mass ratio of the zerumbet solution to the hydrogenated castor oil is 3:1;
the mass ratio of the zerumbone nano microemulsion to the zerumbone extract is 1 (80-120); preferably, the mass ratio of the zerumbet nanometer microemulsion to the zerumbet ginger extract is 1:100.
Further, the power of the ultrasound is 0.1W; the time of the ultrasonic treatment is 10 seconds; the number of times of ultrasound was 3.
Further, the anti-aging skin care product composition also comprises a skin care product matrix.
Further, the skin care product matrix comprises at least one of water, glycerol, 1, 2-pentanediol, xanthan gum, cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone, or phenoxyethanol.
Further, the skin care product matrix is prepared from the following raw materials in parts by weight: 20-40 parts of water, 2-4 parts of glycerin, 0.2-0.4 part of 1, 2-pentanediol, 0.05-0.1 part of xanthan gum, 0.5-1 part of cetostearyl alcohol, 1-2 parts of caprylic/capric triglyceride, 0.5-1 part of polydimethylsiloxane, 0.15-0.3 part of glycerol stearate, 0.3-0.6 part of methyl palmitate, 0.1-0.2 part of p-hydroxyacetophenone and 0.3-0.6 part of phenoxyethanol.
Further, the skin care product matrix is prepared by the following steps:
adding water, glycerol, 1, 2-pentanediol, xanthan gum and betaine into a water phase pot, heating to 35-80 ℃, stirring uniformly, and pumping into a vacuum emulsifying machine;
adding cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone and phenoxyethanol into an oil phase pot, heating to 35-80 ℃, stirring, and pumping into a vacuum emulsifying machine;
mixing, homogenizing, and cooling to obtain a mixture of water and skin care product matrix.
Further, the ratio of the total mass of the functional raw materials to the total mass of the skin care product matrix is 1:100; wherein the total mass of the functional raw materials is the sum of the mass of the high-concentration zedoary turmeric extract, betaine, grape seed oil, beta-carotene and tocopheryl acetate.
The invention also provides a preparation method of the anti-aging skin care product composition according to any one of the above steps, which comprises the following steps:
adding rhizoma Zingiberis recens extract containing high concentration of zerumbet, beta-carotene, grape seed oil, and tocopheryl acetate into skin care product matrix, and mixing to obtain antiaging skin care product composition.
The invention has the following advantages:
the anti-aging skin care product composition provided by the invention is prepared by compounding the zingiber zerumbet extract containing high-concentration zerumbet ketone, betaine, beta-carotene, grape seed oil, tocopheryl acetate and the like, and the comprehensive effects of the components are realized, so that the skin aging is delayed. The skin care product composition has the advantages of safe raw material sources and good application prospect.
Specifically, the zerumbet is used as an effective component of the zerumbet ginger extract, the zerumbet ginger extract has low content, the zerumbet ginger extract is added with the zerumbet ginger extract by preparing the zerumbet ginger ketone into a nano microemulsion state, the zerumbet ginger ketone content is improved, and the zerumbet ginger ketone can radically delay skin aging by inhibiting the degradation of ZEB1 protein and reducing the biosynthesis of aging protein at the downstream of the zerumbet ginger ketone. In addition, the extract of Zingiber zerumbet with high concentration of zerumbet can relieve the inhibition of ultraviolet irradiation on skin superoxide dismutase activity, inhibit the reduction of hydroxyproline content of skin by ultraviolet irradiation, and reduce the generation of malondialdehyde in skin by ultraviolet irradiation.
When the skin is subjected to high osmotic pressure in the external environment, a great deal of cell osmotic quality is lost, so that cell apoptosis is caused, the betaine osmotic quality can inhibit the process, and the betaine osmotic quality can permeate into the skin through the stratum corneum to protect the balance of cells, so that the protection effect of the zerumbet ginger extract containing high-concentration zerumbet ginger ketone on the cells is enhanced. Betaine can also repair DNA, and has effect in recovering damaged skin.
The grape seed oil contains rich linoleic acid, is favorable for promoting the absorption of the body to the tocopheryl acetate, can help skin cells to absorb the nutrient components of the grape seed oil better, has better antioxidant effect after the two are compounded than the single use, and effectively improves the stability of the grape seed oil. Tocopheryl acetate also significantly improves the oxidative stability of beta-carotene.
Therefore, the multi-component comprehensive effect of the zingiber zerumbet extract containing high-concentration zerumbet, betaine, beta-carotene, grape seed oil and tocopheryl acetate can achieve the purposes of lifting and tightening skin and smoothing fine wrinkles and resisting aging by inhibiting the loss of collagen elastic fiber, repairing damaged skin and resisting oxidization.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention. In the drawings:
FIG. 1 is a graph showing the superoxide dismutase content of the skin care products of example 1 and comparative examples 1-6 of the test example 1 of the present invention after the skin of the mice is coated with the skin care products;
FIG. 2 is a graph showing the hydroxyproline content of the skin care products of example 1 and comparative examples 1 to 6 applied to the skin of a mouse in test example 1 according to the present invention;
FIG. 3 is a graph showing malondialdehyde content of the skin care products of example 1 and comparative examples 1 to 6 applied to the skin of a mouse in test example 1 according to the present invention.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. Embodiments of the invention and features of the embodiments may be combined with each other without conflict.
The embodiment of the invention provides an anti-aging skin care product composition which is prepared from the following raw materials in parts by weight: 0.2-0.5 part of zerumbet ginger extract containing high-concentration zerumbet ginger ketone, 0.1-0.3 part of betaine, 0.01-0.05 part of grape seed oil, 0.005-0.01 part of beta-carotene and 0.005-0.01 part of tocopheryl acetate;
wherein, the zerumbone has a structure shown in formula I:
in the embodiment of the invention, the inventor finds that the zerumbet ketone with the structure shown in the formula I has important efficacy in resisting aging, combines the zerumbet ketone with the zerumbet ginger extract, and then acts together with betaine, grape seed oil, beta-carotene, tocopheryl acetate and the like, thereby effectively improving the anti-aging effect of the skin care product composition.
In one embodiment of the invention, the zingiber zerumbet extract containing high concentration of zerumbet ketone is prepared by the steps of:
dissolving zerumbone in dimethyl sulfoxide to obtain zerumbone solution; mixing the zerumbone solution with hydrogenated castor oil (PEG-40), performing ultrasonic treatment, and incubating at 33 ℃ for 20-30 minutes to obtain zerumbone nano-microemulsion; adding the zerumbet nanometer microemulsion into the zerumbet ginger extract, and mixing to obtain the zerumbet ginger extract containing high concentration zerumbet ginger ketone. According to the embodiment of the invention, through a specific preparation method, the zerumbet and the zerumbet ginger extract are fully mixed to obtain the zerumbet ginger extract containing high-concentration zerumbet ginger ketone, so that the effects of the zerumbet ginger ketone and the zerumbet ginger extract in sun-proof aging are effectively improved.
Specifically, the mass ratio of the zerumbone to the dimethyl sulfoxide is 1 (80-120); preferably, the mass ratio of the zerumbone to the dimethyl sulfoxide is 1:100.
Specifically, the mass ratio of the zerumbet solution to the hydrogenated castor oil is (1-5): 1; preferably, the mass ratio of the zerumbet solution to the hydrogenated castor oil is 3:1.
Specifically, the mass ratio of the zerumbet nanometer microemulsion to the zerumbet ginger extract is 1 (80-120); preferably, the mass ratio of the zerumbet nanometer microemulsion to the zerumbet ginger extract is 1:100.
Further, the power of the ultrasound is 0.1w; the time of the ultrasonic treatment is 10 seconds; the number of times of ultrasound was 3.
In one embodiment of the invention, the anti-aging skin care product composition further comprises a skin care product matrix.
In a preferred embodiment of the present invention, the skin care product base comprises water, glycerol, 1, 2-pentanediol, xanthan gum, cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone, phenoxyethanol.
In a preferred embodiment of the invention, the skin care product matrix is prepared from the following raw materials in parts by weight: 20-40 parts of water, 2-4 parts of glycerin, 0.2-0.4 part of 1, 2-pentanediol, 0.05-0.1 part of xanthan gum, 0.5-1 part of cetostearyl alcohol, 1-2 parts of caprylic/capric triglyceride, 0.5-1 part of polydimethylsiloxane, 0.15-0.3 part of glycerol stearate, 0.3-0.6 part of methyl palmitate, 0.1-0.2 part of p-hydroxyacetophenone and 0.3-0.6 part of phenoxyethanol. The skin care product substrate is matched with the high-concentration zerumbet ginger extract, betaine, grape seed oil, beta-carotene, tocopheryl acetate and the like in an auxiliary way, so that the efficacy of the skin care product is further improved, and the application stability of the skin care product is improved.
In one embodiment of the invention, the skin care product matrix is prepared by the steps of:
adding water, glycerol, 1, 2-pentanediol, xanthan gum and betaine into a water phase pot, heating to 35-80 ℃, stirring uniformly, and pumping into a vacuum emulsifying machine;
adding cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone and phenoxyethanol into an oil phase pot, heating to 35-80 ℃, stirring, and pumping into a vacuum emulsifying machine;
mixing, homogenizing, and cooling to obtain skin care product matrix. The time for mixing and homogenizing was 10 minutes. Cooled to room temperature. Wherein the room temperature is 20-30 ℃.
The embodiment of the invention also provides a preparation method of the anti-aging skin care product composition, which comprises the following steps:
adding rhizoma Zingiberis recens extract containing high concentration of zerumbet, beta-carotene, grape seed oil, and tocopheryl acetate into skin care product matrix, and stirring to obtain antiaging skin care product.
The invention will be described in detail with reference to examples.
Example 1An anti-aging skin care product composition is prepared from the following raw materials in parts by weight:
1) Adding 30 parts of water, 4 parts of glycerol, 0.2 part of 1, 2-pentanediol, 0.1 part of xanthan gum and 0.3 part of betaine into a water phase pot, heating to 80 ℃, stirring uniformly, and pumping into a vacuum emulsifying machine;
adding 0.5 part of cetostearyl alcohol, 1 part of caprylic/capric triglyceride, 0.5 part of polydimethylsiloxane, 0.15 part of glycerol stearate, 0.6 part of methyl palmitate, 0.1 part of p-hydroxyacetophenone and 0.3 part of phenoxyethanol into an oil phase pot, heating to 80 ℃, stirring uniformly, and pumping into a vacuum emulsifying machine;
stirring, mixing and homogenizing for 10 minutes, and cooling to room temperature to obtain a skin care product matrix;
2) Adding 0.5 part of the red ball ginger extract containing high-concentration zerumbet, 0.01 part of beta-carotene, 0.05 part of grape seed oil and 0.01 part of tocopheryl acetate into the skin care product matrix, wherein the ratio of the total mass of the functional raw materials to the total mass of the skin care product matrix is 1:100, and uniformly stirring to obtain an anti-aging skin care product;
wherein, the preparation of the extract of the zerumbet ginger containing high concentration zerumbet ginger ketone comprises the following steps:
0.01 part of zerumbone is dissolved in 1 part of dimethyl sulfoxide to obtain zerumbone solution for standby;
mixing 1 part of zerumbone solution with 3 parts of hydrogenated castor oil, carrying out ultrasonic treatment for 10 seconds at 0.1w power, repeating for 3 times, and incubating at 33 ℃ for 30 minutes to enable the components to be fully mutually dissolved to obtain zerumbone nano-microemulsion;
adding 0.01 part of zerumbet nano microemulsion into 1 part of zerumbet ginger extract, and sufficiently oscillating to dissolve the zerumbet ginger extract with high concentration of zerumbet ginger ketone.
Comparative examples 1 to 5
The preparation method of example 1 was repeated according to the raw material content in Table 1, and the kinds and contents of other unlisted components were exactly the same as those of example 1, to obtain the skin care composition having different components, respectively.
TABLE 1
Test example 1Anti-aging effect experiment of anti-aging skin care product composition
54 healthy 1 month old Kunming males, weighing 16+ -1 g, randomized group: blank, model, example 1, comparative examples 1-6, 6 per group. All mice were dehaired on their backs, approximately 2X 2cm 2 Is a square area of (c). The model group, example 1 group, comparative examples 1-6 groups were exposed to UV radiation every other day with a total UV dose of 500mJ/cm per exposure 2 Two weeks in succession. The anti-aging skin care compositions of example 1, comparative examples 1-6 were applied to the groups of example 1, comparative examples 1-5, respectively, prior to each exposure to UV radiation.
According to the grouping, about 1g of skin tissue blocks at the back of each mouse is taken, subcutaneous fat and other connective tissues are removed after the washing of normal saline, the filter paper absorbs water and is weighed, the normal saline with the weight of 8 times of the volume is added and is transferred into a mortar, after the tissue blocks are ground, the tissue blocks are crushed for 3 minutes in an ice bath of an ultrasonic crusher, and the process is repeated for 3 times. The homogenate was centrifuged at 5000rpm/min for 20 min, and the supernatant was assayed according to the protocol described for superoxide dismutase, hydroxyproline, malondialdehyde kit, and the results of the assay are shown in FIGS. 1-3.
As shown in figures 1-3, the extract of rhizoma Zingiberis recens containing high concentration of zerumbet is effective in relieving the inhibition of skin superoxide dismutase activity by ultraviolet irradiation, inhibiting the reduction of skin hydroxyproline content by ultraviolet irradiation, and reducing the formation of malondialdehyde in skin by ultraviolet irradiation. In conclusion, the combination of the components of the extract of the zingiber zerumbet, the betaine, the grape seed oil, the beta-carotene and the tocopheryl acetate with high concentration of the zerumbet ketone is used for obtaining the composition with strong oxidation resistance, ultraviolet injury resistance and aging resistance.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (9)
1. The anti-aging skin care product composition is characterized by being prepared from the following raw materials in parts by weight: 0.2-0.5 part of zerumbet ginger extract containing high-concentration zerumbet ginger ketone, 0.1-0.3 part of betaine, 0.01-0.05 part of grape seed oil, 0.005-0.01 part of beta-carotene and 0.005-0.01 part of tocopheryl acetate;
wherein, the zerumbone has a structure shown in formula I:
a formula I;
the extract of zerumbet ginger containing high concentration zerumbet ginger ketone is prepared by the following steps:
dissolving zerumbone in dimethyl sulfoxide to obtain zerumbone solution; mixing the zerumbone solution with hydrogenated castor oil, performing ultrasonic treatment, and incubating at 37 ℃ for 20-30 minutes to obtain zerumbone nano-microemulsion; adding the zerumbet nano-microemulsion into the zerumbet ginger extract, and mixing to obtain the zerumbet ginger extract containing high-concentration zerumbet ginger ketone;
wherein, the mass ratio of the zerumbone to the dimethyl sulfoxide is 1 (80-120);
the mass ratio of the zerumbone solution to the hydrogenated castor oil is (1-5) 1;
the mass ratio of the zerumbone nano microemulsion to the zerumbone extract is 1 (80-120).
2. An anti-aging skin care composition according to claim 1, wherein,
the mass ratio of the zerumbone to the dimethyl sulfoxide is 1:100;
the mass ratio of the zerumbone solution to the hydrogenated castor oil is 3:1;
the mass ratio of the zerumbone nano microemulsion to the zerumbone extract is 1:100.
3. An anti-aging skin care composition according to claim 1, wherein,
the power of the ultrasonic wave is 0.1W; the time of the ultrasonic treatment is 10 seconds; the number of times of ultrasound was 3.
4. The anti-aging skin care product composition according to any one of claim 1 to 3, wherein,
the anti-aging skin care product composition further comprises a skin care product matrix.
5. The anti-aging skin care composition according to claim 4, wherein,
the skin care product matrix comprises at least one of water, glycerol, 1, 2-pentanediol, xanthan gum, cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone or phenoxyethanol.
6. The anti-aging skin care composition according to claim 5, wherein,
the skin care product matrix is prepared from the following raw materials in parts by weight: 20-40 parts of water, 2-4 parts of glycerin, 0.2-0.4 part of 1, 2-pentanediol, 0.05-0.1 part of xanthan gum, 0.5-1 part of cetostearyl alcohol, 1-2 parts of caprylic/capric triglyceride, 0.5-1 part of polydimethylsiloxane, 0.15-0.3 part of glycerol stearate, 0.3-0.6 part of methyl palmitate, 0.1-0.2 part of p-hydroxyacetophenone and 0.3-0.6 part of phenoxyethanol.
7. The anti-aging skin care composition according to claim 6, wherein,
the skin care product matrix is prepared by the following steps:
adding water, glycerol, 1, 2-pentanediol, xanthan gum and betaine into a water phase pot, heating to 75-80 ℃, stirring uniformly, and pumping into a vacuum emulsifying machine;
adding cetostearyl alcohol, caprylic/capric triglyceride, polydimethylsiloxane, glycerol stearate, methyl palmitate, p-hydroxyacetophenone and phenoxyethanol into an oil phase pot, heating to 75-80 ℃, stirring, and pumping into a vacuum emulsifying machine;
mixing, homogenizing, and cooling to obtain a mixture of water and skin care product matrix.
8. The anti-aging skin care product composition according to any one of claim 4 to 7, wherein,
the ratio of the total mass of the functional raw materials to the total mass of the skin care product matrix is 1:100; wherein the total mass of the functional raw materials is the sum of the mass of the high-concentration zedoary turmeric extract, betaine, grape seed oil, beta-carotene and tocopheryl acetate.
9. The method for preparing the anti-aging skin care product composition according to any one of claims 1 to 8, which is characterized by comprising the following steps:
adding rhizoma Zingiberis recens extract containing high concentration of zerumbet, beta-carotene, grape seed oil, and tocopheryl acetate into skin care product matrix, and mixing to obtain antiaging skin care product composition.
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| FR2985425A1 (en) * | 2012-01-10 | 2013-07-12 | Sederma Sa | NEW USE OF ZERUMBON |
| CN105920217A (en) * | 2016-04-13 | 2016-09-07 | 上海本真食品有限公司 | Beauty keeping and skin moistening grape seed oil and preparation method thereof |
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| FR2985425A1 (en) * | 2012-01-10 | 2013-07-12 | Sederma Sa | NEW USE OF ZERUMBON |
| CN107106478A (en) * | 2015-01-13 | 2017-08-29 | 赛德玛公司 | The plant cell of edelweiss is used for the purposes and corresponding active component of cosmetic treatments |
| CN105920217A (en) * | 2016-04-13 | 2016-09-07 | 上海本真食品有限公司 | Beauty keeping and skin moistening grape seed oil and preparation method thereof |
| CN109288781A (en) * | 2018-09-03 | 2019-02-01 | 芜湖凌梦电子商务有限公司 | Whitening and softening skin essence cream and preparation method thereof |
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