CN106420471B - It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently - Google Patents
It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently Download PDFInfo
- Publication number
- CN106420471B CN106420471B CN201610929941.2A CN201610929941A CN106420471B CN 106420471 B CN106420471 B CN 106420471B CN 201610929941 A CN201610929941 A CN 201610929941A CN 106420471 B CN106420471 B CN 106420471B
- Authority
- CN
- China
- Prior art keywords
- sun
- proof
- skin care
- care item
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention belongs to cosmetic technical field, it is related to and a kind of has sun-proof and after-sun function skin care item and preparation method thereof concurrently.The present invention, which has sun-proof and after-sun function skin care item concurrently, includes following composition：Sodium copper chlorophyllin, cell factor complex liposome, Thallus Gracilariae extract, Lonicera confusa extract, cortex fraxini extract, dipotassium glycyrrhizinate, shea butter, butanediol, beta glucan, Sodium Hyaluronate, xanthans, trehalose, hydrogenated jojoba oil, saualane, ring five dimethyl silicone polymer, cetearyl glucoside, cetostearyl alcohol, the stearates of PEG 100, tocopherol acetate, bisabolol, preservative, essence and deionized water.What the present invention was provided have concurrently, and sun-proof and after-sun function skin care item formula is reasonable, and property is stable, action temperature and, no skin irritation, and by the synergy of various active ingredients, the effects such as with significant sun-proof and after-sun.
Description
Technical field
The invention belongs to cosmetic technical field, it is related to a kind of skin care item and its system for having sun-proof and after-sun function concurrently
Preparation Method.
Background technology
In recent years, with the raising of people's health consciousness, harm of the ultraviolet to skin has caused the extensive concern of people.
A series of biological damages that ultraviolet is produced to skin, not only have influence on the appearance whitening of people, or even threaten human body skin to be good for
Health.With the development of modern society, the rise of the stress-relieving activity such as people's out on tours, outdoor activities increase, skin is exposed to purple
The time lengthening of UV radiation, along with environmental pollution causes the destruction of atmospheric ozone layer, is radiated the ultraviolet of earth surface
It is more and more, therefore, protect the skin from ultraviolet injury and increasingly attracted attention in the modern life, sun-proof class cosmetics
Research and development become one of focus of cosmetics research and development.
Ultraviolet can be divided into long wave ultraviolet UVA (320nm-400nm), ultraviolet B radiation UVB (280nm- by wavelength
320nm) with short wave ultraviolet UVC (100nm-280nm).UVA can penetrate epiderm skin and most skin corium, oxide skin
In reduced form melanin and direct tanning, long duration of action can destroy the elastic fibers in skin, cause skin light
Aging, serious infringement is caused to skin.UVB is weak compared with UVA to skin ability to function, and the overwhelming majority is absorbed by epidermis, on a small quantity
Through epidermis, the nucleic acid or protein denaturation in skin epidermal cells can be made, occur acute dermatitis erythema or burn.
Sun-proof biology is current sun-proof and after-sun class cosmetics research and development focus, is mainly used in natural plants
Some compositions can absorb ultraviolet, the active oxygen radical that ultraviolet radiation is caused be removed or reduce, so as to prevent or reduce
Dermal tissue insult after Exposure to Sunlight, promotes day after-sun, plays indirect anti-sunlight function.Sun-proof interval big, the sensitization rate of biological sun-screening agent
It is low, safe and effective, sun-proof while, also with whitening spot-removing, the anti-ageing effect of waiting for a long time, thus have broad application prospects.
The B of Chinese patent CN 103405363 disclose a kind of sun-proof repair combination, are extracted by aloe extract, radix scutellariae
Thing, green-tea extract, green stone lotus extract, vitamin E, SP, nano level titanium dioxide, isomery hexadecane, jojoba oil,
Saualane, glycerine, anhydrous sorbitol laurate, sorbitan monooleate, xanthans, essence, preservative and deionization
Water is prepared, and UVB and UVA can effectively be absorbed and Isolated Shield.But nano level physical sunscreen agent easily penetrates human body skin
Skin top layer is penetrated into inside skin, has potentially hazardous to health, meanwhile, research shows, nano-TiO2With heredity
Toxicity, can cause DNA oxidative damage, DNA is untwisted and is broken, or even cause apoptosis and the necrosis of cell.
At present, the biological sun-proof class cosmetics of in the market, to improve sun-proof performance, its sun-proof active ingredient is more anti-by biology
Agent and physical sunscreen agent or the compound composition of chemical sun are shone, though it is potential to skin to reduce sun care preparations to a certain extent
Excitant, but because it still contains physical sunscreen agent or chemical sun, comfortableness, stability and the security of product etc. are still
Have much room for improvement.
The content of the invention
It is an object of the invention to overcome existing technological deficiency there is provided a kind of to have sun-proof and after-sun function shield concurrently
Skin product and preparation method thereof.What the present invention was provided has sun-proof and after-sun function skin care item concurrently, with sodium copper chlorophyllin, dragon
Palpus dish extract, Lonicera confusa extract and cortex fraxini extract are main sun-prevention component, each composition synergy, sun-proof interval big,
Sun-proof result is notable.Meanwhile, the present invention is free of physical sunscreen agent and chemical sun, action temperature and no skin irritation, safety
Property it is high.In addition, present invention offer has sun-proof and after-sun function skin care item concurrently and has significant skin whitening, moisturizing effect, to purple
Acute dermatitis erythema has significant mitigation caused by UV radiation.
Technical scheme is as follows：
It is a kind of to have sun-proof and after-sun function skin care item concurrently, by weight percentage, including following composition：Chlorophyll
Copper sodium 4-8%, cell factor complex liposome 1-2%, Thallus Gracilariae extract 3-5%, Lonicera confusa extract 2-4%, the bark of ash
Extract 2-5%, dipotassium glycyrrhizinate 0.05-0.2%, shea butter 5-10%, butanediol 5-10%, beta glucan 1-3%, thoroughly
The sour sodium 0.02-0.1% of bright matter, xanthans 0.08-0.2%, trehalose 0.8-1.5%, hydrogenated jojoba oil 3-6%, saualane
2-5%, ring five dimethyl silicone polymer 2-5%, cetearyl glucoside 1-4%, cetostearyl alcohol 1-3%, PEG-100 are hard
Resin acid ester 1-3%, tocopherol acetate 0.3-0.6%, bisabolol 0.1-0.4%, preservative 0.5-1%, essence 0.01-
0.05% and deionized water 25-63%；
Wherein, interleukin 12 and EGF are contained in cell factor complex liposome.
Further, the cell factor complex liposome, is counted by weight, including following component：Interleukins-
120.002-0.005 parts, 0.001-0.002 parts of EGF, 5-15 parts of naked oats protein zymolyte, hydrolecithin 80-
120 parts, 20-30 parts of 1-3 parts of sodium taurocholate and cholesterol.
Further, in the cell factor complex liposome, the preparation method of naked oats protein zymolyte includes following step
Suddenly：
A. naked oats flour is taken, the water that 12-15 times of its quality is measured, the NaOH solution for being 1-2mol/L with concentration after mixing is added
PH to 10-12 is adjusted, is 42-48 DEG C in temperature, power is ultrasonically treated 40-60min, 3000- under conditions of 200-250W
4000r/min centrifuges 20-25min, with 200 mesh filter-cloth filterings, takes supernatant, plus concentration to be adjusted for 0.5-1mol/L HCl solution
PH value is saved to 4.0,10-15min, 3000-4000r/min centrifugation 20-25min is stood, takes precipitation, be freeze-dried, obtain naked oats egg
In vain；
B. naked oats albumen is taken, is added water by solid-to-liquid ratio 8-12g/L, total solution weight 8-12% alkalescence is stirring evenly and then adding into
Protease, is 58-65 DEG C in temperature, and pH value is digests 4-6h under conditions of 8.5-9.0, enzymolysis process keeps solution ph not
Become, 100 DEG C of enzyme 5-8min that go out after enzymolysis terminates, centrifuging and taking supernatant, is concentrated under reduced pressure after cooling, spray drying produces naked oats egg
White zymolyte.
Further, the preparation method of the cell factor complex liposome comprises the following steps：
1) hydrolecithin, sodium taurocholate and cholesterol are taken, is added by solid-to-liquid ratio 2-5mg/mL in absolute ethyl alcohol, is stirred molten
Solution, obtains solution I；
2) interleukin 12, EGF and naked oats protein zymolyte are taken, is added by solid-to-liquid ratio 2-5mg/mL
PBS, stirring and dissolving obtains solution II；
3) by step 1) solution I and step 2) solution II adds supercritical autoclave, is 30-40 in temperature
DEG C, pressure is 20-28MPa, CO2Flow is emulsifies 30-45min under conditions of 12-16L/h, and decompression separation emulsification product is obtained carefully
Intracellular cytokine composite liposome body；Wherein, separation temperature is 30-40 DEG C, and separating pressure is 5-15MPa.
Further, in the cell factor complex lipid preparation, step 3) pH of the PBS is 6.8-7.0,
Concentration is 0.01-0.03mol/L.
Further, the preservative is glycerol caprylate, 1,2- pentanediols and Herba Lophatheri extract by weight 1:1-
2:The preservative of 0.3-0.6 compounding compositions, wherein, Herba Lophatheri extract is grass henon bamboo leaf (Lophatherum
Gracile Bongn.) cauline leaf extract, purchased from Xi'an Bioisystech Co., Ltd of Tianrui.
What the present invention was provided has sun-proof and after-sun function skin care item concurrently with sodium copper chlorophyllin, asparagus extraction
Thing, Lonicera confusa extract and cortex fraxini extract are main sun-prevention component, without physical sunscreen agent and chemical sun, action temperature
With no skin irritation is safe.
Chlorophyll belongs to pyrrole derivatives species pigment, and catalytic action is played in photosynthesis, has light absorbs containing one
Singly-bound and the conjugated system of double bond formation absorb some visible light in the porphyrin ring of ability, porphyrin ring.Now there are some researches show Ye Lv
Element has dual sun-proof function, can absorb simultaneously and scatters ultraviolet.Chlorophyll molecule is unstable in its natural state, easily decomposes
Inactivation, therefore the present invention uses sodium copper chlorophyllin as sun-prevention component, improves the stability of product.
Thallus Gracilariae extract is the frond of fragrant plant mentioned in ancient texts section fragrant plant mentioned in ancient texts platymiscium asparagus (Gracilaria lemaneiformis)
Extract, purchased from Xi'an Bioisystech Co., Ltd of Tianrui, the composition such as protein containing algae red, mucin and cholesterine, with moisturizing,
Anti-inflammatory and sun-proof function.Lonicera confusa extract for caprifoliaceae plant Honeysuckle flower (Lonicera confusae DC.) bud or
The extract for the flower that band is just opened, purchased from Xi'an Bioisystech Co., Ltd of Tianrui, containing volatile oil, chlorogenic acid, isochlorogenic acid, sweet-scented osmanthus
The compositions such as careless element, the effects such as with anti-inflammatory, antipyretic, anti-oxidant, scavenging capacity oxygen radical.Cortex fraxini extract is that Oleaceae falls
Leaf magaphanerophytes hardship manger's Chinese wax (Fraxinus rhynchophlla Hance) or Fraxinus bungeana (Fraxinus bungeana
DC. the extract of stem skin), purchased from Xi'an Bioisystech Co., Ltd of Tianrui, containing coumarin kind compound, to UVA and UVB
It is respectively provided with larger absorption.
Sodium copper chlorophyllin, Thallus Gracilariae extract, Lonicera confusa extract and cortex fraxini extract compounding are used as sun-screening agent application
In sun care preparations, collaboration is acted between each composition, the sun-proof ability and sun-proof effect of sun care preparations, sun-proof result can be improved
Significantly.
UVB can cause the DNA break of horn cell, promote horn cell to occur apoptosis, and the DNA damage that it is induced is main
Intracellular cyclobutane pyrimidine dimer (CPDs) substantial increase is embodied in, causes a large amount of sunburn cells (SCs) formation, makes skin
The physical barriers of skin are by heavy damage.Research shows that interleukin 12 can effectively repair the skin DNA caused by radiation
Damage, is greatly lowered intracellular CPDs, reduces sunburn cells number, recovers impaired cutaneous immunisation state, increase skin
Moisture, so that with significant after-sun function.
EGF can effectively facilitate cytothesis and tissue repair, accelerate the metabolism of cell, so as to promote
The synthesis of hyaluronic acid and collagen etc., so as to reach the work repaired wound, eliminate color spot and pigmentation and the tender skin of moisturizing
With.
Naked oats protein zymolyte is containing abundant proteins and peptides composition, it is easy to is absorbed by the skin utilization, has to skin
Preferable skin-moisturizing, skin and antioxidation.Naked oats protein zymolyte has positive association with interleukin 12, EGF
Same-action, one side naked oats protein zymolyte can keep the abundant moisture of skin, so as to well maintain interleukins-
12 and the bioactivity of EGF, another aspect three collaboration can improve oozing for each active ingredient of composite liposome body
Permeability, is conducive to absorption of the skin to each active component, improves its bioavilability.
Sensitive inflammation phenomenon, there is anti-inflammatory sedation to inflammation when dipotassium glycyrrhizinate can prevent skin stimulated；Newborn fruit tree
Oil has been absorbed by the skin, can nourishes rough skin, safeguard elastin, improve skin elasticity.Cell factor complex liposome and radix glycyrrhizae
Sour dipotassium, the oily compound use of newborn fruit tree, with significant nutrition skin, the work(for promoting skin tissue regeneration, repairing skin injury
Effect.
What the present invention was provided have concurrently, and sun-proof and after-sun function skin care item formula is reasonable, and property is stable, action temperature and,
Without skin irritation, and by the synergy of various active ingredients, the effects such as with significant sun-proof and after-sun.
Correspondingly, the present invention also provides a kind of system of the present invention for having sun-proof and after-sun function skin care item concurrently
Preparation Method, comprises the following steps：
S1：Take shea butter, hydrogenated jojoba oil, saualane, ring five dimethyl silicone polymer, cetostearyl alcohol, PEG-
100 stearates, tocopherol acetate and bisabolol are added in oil cauldron, are heated to 80-85 DEG C, constant temperature is stirred to complete
Dissolving, obtains material A；
S2：Extracting liquorice acid dipotassium, butanediol, Sodium Hyaluronate, xanthans, trehalose, cetearyl glucoside and go
Ionized water is added in aqueous phase pot, is heated to 80-85 DEG C, constant temperature, which is stirred to after being completely dissolved, is pumped into warmed-up emulsifying
In pot, stirring is opened, material A is slowly pumped into emulsification pot, carries out emulsifying, speed of agitator is 2500-3000r/min,
The emulsifying time is 5-10min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40-45 DEG C, sodium copper chlorophyllin, cell factor complex liposome, β-Portugal are added
Glycan, Thallus Gracilariae extract, Lonicera confusa extract, cortex fraxini extract, preservative and essence, carry out second of emulsifying, stir
Mix rotating speed is 500-700r/min, and the emulsifying time is 2-5min, vacuum defoamation, is cooled to room temperature, sampling Detection, it is qualified go out
Material, is produced.
Compared with prior art, the beneficial effects of the invention are as follows：
1) what the present invention was provided has sun-proof and after-sun function skin care item concurrently, is carried with sodium copper chlorophyllin, asparagus
It is main sun-prevention component to take thing, Lonicera confusa extract and cortex fraxini extract, each composition synergy, sun-proof interval big, sun-proof effect
Fruit significantly, meanwhile, the present invention be free of physical sunscreen agent and chemical sun, action temperature and, no skin irritation is safe；
2) what the present invention was provided has sun-proof and after-sun function skin care item formula concurrently rationally, and property is stable, action temperature
With, no skin irritation, and by the synergy of various active ingredients, the effects such as with significant sun-proof and after-sun；
3) preparation method for having sun-proof and after-sun function skin care item concurrently that the present invention is provided is simple, process stabilizing,
It is convenient to carry out, can industrialized production, be conducive to popularization and application.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.This
In inventive embodiments unless otherwise instructed, raw materials used is conventional commercial product.
The preparation of the naked oats protein zymolyte of embodiment 1
Comprise the following steps：
A. naked oats flour is taken, the water of 12 times of amounts of its quality, the NaOH solution for being 1mol/L with concentration after mixing regulation is added
PH to 10.5, is 45 DEG C in temperature, and power is ultrasonically treated 45min under conditions of 200W, 4000r/min centrifugation 20min, is used
200 mesh filter-cloth filterings, take supernatant, plus concentration to adjust pH value to 4.0 for 1mol/L HCl solution, stand 10min, 4000r/
Min centrifuges 20min, takes precipitation, is freeze-dried, obtains naked oats albumen；
B. naked oats albumen is taken, is added water by solid-to-liquid ratio 10g/L, the basic protein of total solution weight 10% is stirring evenly and then adding into
Enzyme, is 60 DEG C in temperature, and pH value is to digest 6h under conditions of 8.5, and enzymolysis process keeps solution ph constant, after enzymolysis terminates
100 DEG C of enzyme 5min that go out, centrifuging and taking supernatant, is concentrated under reduced pressure after cooling, spray drying, produces naked oats protein zymolyte.
The preparation method of the cell factor complex liposome of embodiment 2
The present embodiment cell factor complex liposome, is counted by weight, including following component：Interleukins-
120.003 parts, 0.001 part of EGF, embodiment 1 prepare 10 parts of naked oats protein zymolyte, hydrolecithin 100
Part, 25 parts of 2 parts of sodium taurocholate and cholesterol.
Comprise the following steps：
1) hydrolecithin, sodium taurocholate and cholesterol are taken, is added by solid-to-liquid ratio 3mg/mL in absolute ethyl alcohol, stirring and dissolving,
Obtain solution I；
2) interleukin 12, EGF and naked oats protein zymolyte are taken, pH is added by solid-to-liquid ratio 3.5mg/mL
For 6.8, concentration is 0.02mol/L PBS, and stirring and dissolving obtains solution II；
3) by step 1) solution I and step 2) solution II adds supercritical autoclave, is 30 DEG C in temperature, pressure
Power is 25MPa, CO2Flow is emulsifies 40min under conditions of 15L/h, and decompression separation emulsification product obtains cytokine complex fat
Plastid；Wherein, separation temperature is 30 DEG C, and separating pressure is 8MPa.
Embodiment 3 has the preparation of sun-proof and after-sun function skin care item concurrently
The present embodiment has sun-proof and after-sun function skin care item concurrently, by weight percentage, is made up of following composition：
Sodium copper chlorophyllin 5%, the cell factor complex liposome 1% of the preparation of embodiment 2, Thallus Gracilariae extract 3%, Honeysuckle flower are extracted
Thing 3%, cortex fraxini extract 5%, dipotassium glycyrrhizinate 0.1%, shea butter 6%, butanediol 6%, beta glucan 2%, hyalomitome
Sour sodium 0.05%, xanthans 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, saualane 2%, ring five dimethyl silicone polymer
4%th, cetearyl glucoside 2%, cetostearyl alcohol 1%, PEG-100 stearates 1.5%, tocopherol acetate 0.4%,
Bisabolol 0.1%, preservative 0.7%, essence 0.01% and deionized water 52.04%；Wherein, preservative is by glycerine octanoic acid
Ester, 1,2- pentanediols and Herba Lophatheri extract are by weight 1:1:0.4 compounding composition
Preparation method：
S1：Take shea butter, hydrogenated jojoba oil, saualane, ring five dimethyl silicone polymer, cetostearyl alcohol, PEG-
100 stearates, tocopherol acetate and bisabolol are added in oil cauldron, are heated to 85 DEG C, constant temperature is stirred to completely molten
Solution, obtains material A；
S2：Extracting liquorice acid dipotassium, butanediol, Sodium Hyaluronate, xanthans, trehalose, cetearyl glucoside and go
Ionized water is added in aqueous phase pot, is heated to 85 DEG C, and constant temperature, which is stirred to after being completely dissolved, is pumped into warmed-up emulsifying pot
In, stirring is opened, material A is slowly pumped into emulsification pot, carries out emulsifying, speed of agitator is 3000r/min, emulsifying
Time is 8min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40 DEG C, addition sodium copper chlorophyllin, cell factor complex liposome, β-Portugal gather
Sugar, Thallus Gracilariae extract, Lonicera confusa extract, cortex fraxini extract, preservative and essence, carry out second of emulsifying, stirring
Rotating speed is 600r/min, and the emulsifying time is 4min, and vacuum defoamation is cooled to room temperature, and sampling Detection, qualified discharging is produced.
Embodiment 4 has the preparation of sun-proof and after-sun function skin care item concurrently
The present embodiment has sun-proof and after-sun function skin care item concurrently, by weight percentage, is made up of following composition：
Sodium copper chlorophyllin 6%, cell factor complex liposome 1.5%, Thallus Gracilariae extract 4%, the Honeysuckle flower of the preparation of embodiment 2 are carried
Take thing 3%, it is cortex fraxini extract 4%, dipotassium glycyrrhizinate 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthans 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, saualane 3%, the polydimethylsiloxanes of ring five
Alkane 3%, cetearyl glucoside 2%, cetostearyl alcohol 2%, PEG-100 stearates 2%, tocopherol acetate 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, the preservative is by caprylic
Acid esters, 1,2- pentanediols and Herba Lophatheri extract are by weight 1:2:0.3 compounding composition.
Preparation method be the same as Example 3.
Comparative example 1
1) cell factor complex liposome is prepared：Count by weight, including following component：Interleukin 12 0.003
25 parts of part, 0.001 part of EGF, 100 parts of hydrolecithin, 2 parts of sodium taurocholate and cholesterol.
The preparation method be the same as Example 2 of cell factor complex liposome is similar.
2) prepare and have sun-proof and after-sun function skin care item concurrently：By weight percentage, it is made up of following composition：Leaf
Green plain copper sodium 6%, cell factor complex liposome 1.5%, Thallus Gracilariae extract 4%, the Honeysuckle flower of the preparation of this comparative example are carried
Take thing 3%, it is cortex fraxini extract 4%, dipotassium glycyrrhizinate 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthans 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, saualane 3%, the polydimethylsiloxanes of ring five
Alkane 3%, cetearyl glucoside 2%, cetostearyl alcohol 2%, PEG-100 stearates 2%, tocopherol acetate 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, the preservative is by caprylic
Acid esters, 1,2- pentanediols and Herba Lophatheri extract are by weight 1:2:0.3 compounding composition.
Preparation method be the same as Example 4 is similar.
The difference of comparative example 1 and embodiment 4 is, naked oats proteolysis is free of in the cell factor complex liposome
Thing.
Comparative example 2
This comparative example has sun-proof and after-sun function skin care item concurrently, by weight percentage, is made up of following composition：
Sodium copper chlorophyllin 6%, cell factor complex liposome 1.5%, Thallus Gracilariae extract 4%, the Honeysuckle flower of the preparation of embodiment 2 are carried
Take thing 3%, it is Baical Skullcap root P.E 4%, dipotassium glycyrrhizinate 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthans 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, saualane 3%, the polydimethylsiloxanes of ring five
Alkane 3%, cetearyl glucoside 2%, cetostearyl alcohol 2%, PEG-100 stearates 2%, tocopherol acetate 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, the preservative is by caprylic
Acid esters, 1,2- pentanediols and Herba Lophatheri extract are by weight 1:2:0.3 compounding composition.Preparation method be the same as Example 9 is similar.
The difference of comparative example 2 and embodiment 4 is, cortex fraxini extract is replaced with Baical Skullcap root P.E.
The human skin patch of test example one
With reference to the Ministry of Public Health《Cosmetics health specification》In (version in 2007) related request of " human skin patch " and
Method carries out " human body skin enclosed type patch test ".
1st, given the test agent：What 3-4 of the embodiment of the present invention, comparative example 1-2 were prepared has sun-proof and after-sun function concurrently
Skin care item.
2nd, test method：The volunteer that selection 140 meets inclusion criteria participates in experiment, is randomly divided into 4 groups, every group 35
People.Device is tried from qualified spot, 0.025g given the test agent is added in spot examination device, and is sticked spot examination device with non-stimulated adhesive tape cloth
In the bent side of the forearm of trial volunteer, gently pressed with palm and be allowed to equably be pasted on skin, the examination of tested material spot is removed after 24h
Device, respectively at observing dermoreaction after 30min, 2h, 4h, 24h and 48h, according to《Skin adverse reaction grade scale table》Record
Reaction result.
3rd, result of the test：Embodiment 3-4, the result of the test of all trial volunteers of comparative example 1-2 groups are negative findings,
Thus it can determine that, what 3-4 of the embodiment of the present invention, comparative example 1-2 were prepared has sun-proof and after-sun function skin care item concurrently
Without skin adverse reaction.It is safe that what the present invention was provided has sun-proof and after-sun function skin care item concurrently.
The sun-proof performance test of test example two
1st, SPF (spf value) is determined
With reference to the Ministry of Public Health《Cosmetics health specification》" sun care preparations SPF (spf value) is determined in (version in 2007)
The related request and assay method of method " are carried out.Given the test agent be 3-4 of the embodiment of the present invention, comparative example 1-2 prepare it is simultaneous
Sun-proof and after-sun function the skin care item of tool.Choose 60 trial volunteers to be tested, be randomly divided into 4 groups, every group of 15 people.
2nd, long wave ultraviolet protection index (PFA values) is determined
With reference to the Ministry of Public Health《Cosmetics health specification》" sun care preparations long wave ultraviolet protection index in (version in 2007)
The related request and assay method of (PFA values) assay method " are carried out.Given the test agent is 3-4 of the embodiment of the present invention, comparative example 1-2
What is prepared has sun-proof and after-sun function skin care item concurrently.Choose 60 trial volunteers to be tested, be randomly divided into 4
Group, every group of 15 people.
3rd, test result：It is shown in Table 1.
The present invention of table 1 has the sun-proof the performance test results of sun-proof and after-sun function skin care item concurrently
| Group | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 |
| Spf value | 28 | 30 | 20 | 18 |
| PFA values | 8 | 10 | 3 | 4 |
| PA grades | PA+++ | PA+++ | PA+ | PA++ |
Sun-proof and after-sun work(is had concurrently from what the test result of table 1 can be seen that 3-4 of the embodiment of the present invention prepares
Can skin care item spf value more than 25, PA grades reach PA+++, illustrate it is of the invention provide have sun-proof and after-sun concurrently
The skin care item of function are respectively provided with good absorption and barrier property to UVB and UVA, and sun-proof result is notable.It is simultaneous that the present invention is provided
Sun-proof and after-sun function the skin care item sun-proof result of tool is substantially better than comparative example group.
The sensory evaluation of test example three
1st, given the test agent：What 3-4 of the embodiment of the present invention, comparative example 1-2 were prepared has sun-proof and after-sun function concurrently
Skin care item.
2nd, test method：Choose 200 skin healths and the women trial volunteer without allergic history participates in experiment, will
All trial volunteers are randomly divided into 4 groups, every group of 50 people.Each group trial volunteer tries out above-mentioned given the test agent respectively, continuously makes
With one month, try out after terminating, the using effect such as each trial volunteer this self-assessment moisturizing, whitening, sun-proof, overall assessment is done
Sensory evaluation, according to using effect in a 0-10/marking, 9-10 points are fine, and 7-8 points are preferable, and 5-6 points are general, 3-
4 points are poor, and 1-2 points are very poor, are averaged.
3rd, result of the test：It is shown in Table 2.
The present invention of table 2 has sun-proof and after-sun function skin care item effect assessment concurrently
| Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | |
| Sun-proof result | 8.5 | 8.9 | 7.2 | 6.8 |
| Moistening effect | 8.2 | 8.6 | 5.7 | 7.2 |
| Whitening effect | 8.5 | 8.7 | 6.8 | 7.1 |
| After-sun effect | 8.6 | 8.8 | 5.6 | 6.8 |
| Clearly without greasy feeling | 8.4 | 8.6 | 7.5 | 7.4 |
| Assimilation effect | 8.2 | 8.5 | 6.8 | 7.3 |
| Overall assessment | 8.2 | 8.5 | 6.4 | 6.9 |
As can be known from the results of Table 2, what prepared by 3-4 of the embodiment of the present invention has sun-proof and after-sun function skin care item concurrently
Degree of recognition is high, and using effect is evaluated high.What the present invention was prepared have concurrently sun-proof and after-sun function skin care item it is sun-proof and
Significantly, after use, skin is clearly without greasy feeling, good absorbing effect for after-sun effect.Continuously using after one month, volunteer tested
The phenomenons such as person's dry skin, epidermal pigment calmness are obviously improved.In process of the test, trial volunteer is without allergy or other skins
Adverse reaction.What contrast 1-2 was prepared has sun-proof and after-sun function skin care item using effect concurrently not as embodiment 3-4
What is prepared has sun-proof and after-sun function skin care item concurrently.
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
The specific implementation of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (6)
1. a kind of have sun-proof and after-sun function skin care item concurrently, it is characterised in that the skin care item by weight percentage,
Including following composition：Sodium copper chlorophyllin 4-8%, cell factor complex liposome 1-2%, Thallus Gracilariae extract 3-5%, mountain silver
Flower extract 2-4%, cortex fraxini extract 2-5%, dipotassium glycyrrhizinate 0.05-0.2%, shea butter 5-10%, butanediol 5-
10%th, beta glucan 1-3%, Sodium Hyaluronate 0.02-0.1%, xanthans 0.08-0.2%, trehalose 0.8-1.5%, hydrogenation
Jojoba oil 3-6%, saualane 2-5%, ring five dimethyl silicone polymer 2-5%, cetearyl glucoside 1-4%, spermaceti
Stearyl alcohol 1-3%, PEG-100 stearate 1-3%, tocopherol acetate 0.3-0.6%, bisabolol 0.1-0.4%, anti-corrosion
Agent 0.5-1%, essence 0.01-0.05% and deionized water 25-63%；
Wherein, the cell factor complex liposome, is counted by weight, including following component：Interleukin 12
0.002-0.005 parts, 0.001-0.002 parts of EGF, 5-15 parts of naked oats protein zymolyte, hydrolecithin 80-120
Part, 20-30 parts of 1-3 parts of sodium taurocholate and cholesterol.
2. have sun-proof and after-sun function skin care item concurrently as claimed in claim 1, it is characterised in that the cell factor
In complex liposome, the preparation method of naked oats protein zymolyte comprises the following steps：
A. naked oats flour is taken, the water that 12-15 times of its quality is measured is added, the NaOH solution for being 1-2mol/L with concentration after mixing regulation
PH to 10-12, is 42-48 DEG C in temperature, power is ultrasonically treated 40-60min, 3000-4000r/ under conditions of 200-250W
Min centrifuges 20-25min, and with 200 mesh filter-cloth filterings, it is 0.5-1mol/L HCl solution regulation pH value to take supernatant, plus concentration
To 4.0,10-15min, 3000-4000r/min centrifugation 20-25min are stood, precipitation is taken, is freeze-dried, obtains naked oats albumen；
B. naked oats albumen is taken, is added water by solid-to-liquid ratio 8-12g/L, total solution weight 8-12% basic protein is stirring evenly and then adding into
Enzyme, is 58-65 DEG C in temperature, and pH value is digests 4-6h under conditions of 8.5-9.0, enzymolysis process keeps solution ph constant, enzyme
100 DEG C of enzyme 5-8min that go out after solution terminates, centrifuging and taking supernatant, is concentrated under reduced pressure after cooling, spray drying, produces naked oats proteolysis
Thing.
3. have sun-proof and after-sun function skin care item concurrently as claimed in claim 1, it is characterised in that the cell factor
The preparation method of complex liposome comprises the following steps：
1) hydrolecithin, sodium taurocholate and cholesterol are taken, is added by solid-to-liquid ratio 2-5mg/mL in absolute ethyl alcohol, stirring and dissolving is obtained
Solution I；
2) interleukin 12, EGF and naked oats protein zymolyte are taken, PBS is added by solid-to-liquid ratio 2-5mg/mL, stirs
Dissolving is mixed, solution II is obtained；
3) by step 1) solution I and step 2) solution II adds supercritical autoclave, is 30-40 DEG C in temperature, pressure
Power is 20-28MPa, CO2Flow is to emulsify 30-45min under conditions of 12-16L/h, decompression separation emulsification product, obtain cell because
Sub- composite liposome body；Wherein, separation temperature is 30-40 DEG C, and separating pressure is 5-15MPa.
4. have sun-proof and after-sun function skin care item concurrently as claimed in claim 3, it is characterised in that the cell factor is answered
Close method for preparing lipidosome in, step 3) PBS pH be 6.8-7.0, concentration is 0.01-0.03mol/L.
5. have sun-proof and after-sun function skin care item concurrently as claimed in claim 1, it is characterised in that the preservative is
Glycerol caprylate, 1,2- pentanediols and Herba Lophatheri extract are by weight 1:1-2:The preservative of 0.3-0.6 compounding compositions.
6. the preparation method for having sun-proof and after-sun function skin care item concurrently as described in claim 1-5 is any, its feature
It is, comprises the following steps：
S1：Take shea butter, hydrogenated jojoba oil, saualane, ring five dimethyl silicone polymer, cetostearyl alcohol, PEG-100 hard
Resin acid ester, tocopherol acetate and bisabolol are added in oil cauldron, are heated to 80-85 DEG C, and constant temperature is stirred to being completely dissolved,
Obtain material A；
S2：Extracting liquorice acid dipotassium, butanediol, Sodium Hyaluronate, xanthans, trehalose, cetearyl glucoside and deionization
Water is added in aqueous phase pot, is heated to 80-85 DEG C, and constant temperature, which is stirred to after being completely dissolved, is pumped into warmed-up emulsifying pot
In, stirring is opened, material A is slowly pumped into emulsification pot, carries out emulsifying, speed of agitator is 2500-3000r/min,
Matter emulsification times are 5-10min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40-45 DEG C, add sodium copper chlorophyllin, cell factor complex liposome, beta glucan,
Thallus Gracilariae extract, Lonicera confusa extract, cortex fraxini extract, preservative and essence, carry out second of emulsifying, speed of agitator
For 500-700r/min, the emulsifying time is 2-5min, vacuum defoamation, is cooled to room temperature, sampling Detection, qualified discharging, i.e.,
.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610929941.2A CN106420471B (en) | 2016-10-31 | 2016-10-31 | It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610929941.2A CN106420471B (en) | 2016-10-31 | 2016-10-31 | It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106420471A CN106420471A (en) | 2017-02-22 |
| CN106420471B true CN106420471B (en) | 2017-08-25 |
Family
ID=58177341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610929941.2A Active CN106420471B (en) | 2016-10-31 | 2016-10-31 | It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106420471B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
| CN107157892A (en) * | 2017-06-22 | 2017-09-15 | 西林县大银子铁皮石斛种销农民专业合作社 | It is a kind of to be used to repair dendrobium candidum clay mask of acne print and preparation method thereof |
| CN107714547A (en) * | 2017-11-02 | 2018-02-23 | 宁波凯斯宝玛卫厨有限公司 | A kind of sun screen |
| CN107854404B (en) * | 2017-12-25 | 2021-04-23 | 吉安智企企业服务有限公司 | Sunscreen skin care product containing herba Centellae extract and its preparation method |
| CN107854339B (en) * | 2017-12-25 | 2021-02-12 | 金鹏飞 | Sunscreen skin care lotion with high stability and preparation method thereof |
| CN108186438B (en) * | 2018-02-09 | 2020-11-24 | 广东科玮生物技术股份有限公司 | After-sun repair gel containing cell growth factors and preparation method thereof |
| CN108670905B (en) * | 2018-07-17 | 2021-02-05 | 唯美爱科技(中国)有限公司 | Liquid crystal type emulsion with sun-screening and after-sun repairing functions and preparation method thereof |
| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
| CN109662928A (en) * | 2019-02-14 | 2019-04-23 | 成都市葆姿健康管理有限公司 | A kind of skin care compositions and its application and preparation method with sun-proof reparation effect |
| CN111714389A (en) * | 2020-07-28 | 2020-09-29 | 广州美兮生物科技有限公司 | Compound sunscreen agent, sunscreen cosmetic and preparation method thereof |
| CN113633584A (en) * | 2021-08-23 | 2021-11-12 | 南方海洋科学与工程广东省实验室(湛江) | Asparagus polyphenol moisturizing skin care product and preparation method thereof |
| CN114767605A (en) * | 2022-04-30 | 2022-07-22 | 杭州千岛湖蓝色天使实业有限公司 | Sunscreen repair emulsion and preparation method thereof |
| CN115252510B (en) * | 2022-09-29 | 2022-12-13 | 广东粤港澳大湾区黄埔材料研究院 | Sunscreen composition and application thereof |
| CN115670968B (en) * | 2022-10-31 | 2023-08-25 | 梅晔生物医药股份有限公司 | Composition with anti-inflammatory and allergy-relieving effects and daily chemical product |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420433C (en) * | 2006-09-27 | 2008-09-24 | 广州市采诗化妆品有限公司 | Pure natural plant additive of sunproofing cosmetics |
| CN102247300A (en) * | 2010-12-24 | 2011-11-23 | 天津天狮生物发展有限公司 | Human epidermal growth factor nanoliposome and its preparation method |
| CN102793642B (en) * | 2012-08-28 | 2014-01-15 | 广州丹奇日用化工厂有限公司 | Skin care product composition |
| CN102827899B (en) * | 2012-09-18 | 2013-11-27 | 国家海洋局第三海洋研究所 | Gracilaria lemaneiformis agar oligosaccharide and preparation method and application thereof |
-
2016
- 2016-10-31 CN CN201610929941.2A patent/CN106420471B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106420471A (en) | 2017-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106420471B (en) | It is a kind of to have sun-proof and after-sun function skin care item and preparation method thereof concurrently | |
| CN102302417B (en) | Comprehensive-effect sunscreen lotion containing oceanic biological active substances | |
| CN103191042A (en) | Skin care agent capable of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing | |
| CN109453087B (en) | Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive | |
| CN109288715A (en) | A kind of whitening remediation composition and preparation method thereof | |
| CN102293733A (en) | Overall whitening and speckle removal skin care product | |
| CN105381007A (en) | Externally-applied traditional Chinese medicine composition with effect on whitening skin, preparation as well as preparation method and application thereof | |
| CN109662928A (en) | A kind of skin care compositions and its application and preparation method with sun-proof reparation effect | |
| CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
| CN107213096A (en) | A kind of plant type suncream and preparation method thereof | |
| CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
| CN115252510B (en) | Sunscreen composition and application thereof | |
| KR20100000081A (en) | Cosmetic composition comprising wild plants ferment extract | |
| CN108014060B (en) | Sunscreen synergistic composition and application thereof | |
| KR101036933B1 (en) | (multi-functional cosmetic composition | |
| KR101370990B1 (en) | Anti-heat aging effect of fermented Limonia acidissima extract and its cosmetic usage to improve skin problems | |
| CN111821230A (en) | Anti-allergy repairing cosmetic composition and application thereof | |
| KR101139373B1 (en) | Cosmetic composition for skinwhitening and manufacturing method thereof and mask-pack containing this | |
| CN110115706A (en) | Resveratrol after-sun recovery product and its production method | |
| CN110897905A (en) | Ginseng eye nutrition essence and preparation method thereof | |
| CN109010572A (en) | A kind of Chinese medicine composition and its preparation method and application with sun-proof synergy and anti-aging effects | |
| CN114805485A (en) | Chlorella bioactive peptide and application thereof in preparation of anti-aging essence | |
| CN103622880A (en) | Application of litsea cubeba oil in sunscreen product and sunscreen composition | |
| CN106937918A (en) | A kind of natural radiation-preventing composition and its application | |
| CN114533613A (en) | Whitening cosmetic composition and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230721 Address after: Building 102, Building 1, No. 76, Xieshi Road, Shibi Street, Shibi Village, Panyu District, Guangzhou City, Guangdong Province, 511496 Patentee after: Guangdong Kewei Zhili Biopharmaceutical Co.,Ltd. Address before: Room 301, 401, 39 BAOYING Avenue, Guangzhou Free Trade Zone, Guangdong 510730 Patentee before: GUANGDONG COOWAY BIOTECHNOLOGY Co.,Ltd. |