CN106420471A - Skin care product with sunscreen and sun repair functions and preparation method thereof - Google Patents
Skin care product with sunscreen and sun repair functions and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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Abstract
The invention belongs to the technical field of cosmetics, and relates to a skin care product with sunscreen and sun repair functions and a preparation method thereof. The skin care product with the sunscreen and sun repair functions comprises the following components: sodium copper chlorophyllin, cytokine complex liposome, an asparagus extract, a flos lonicerae extract, an ash bark extract, dipotassium glycyrrhizinate, shea butter, butanediol, beta-glucan, sodium hyaluronate, xanthan gum, trehalose, hydrogenated jojoba oil, squalane, cyclopentasiloxane, cetearyl glucoside, cetearyl alcohol, PEG-100 stearate, tocopheryl acetate, bisabolol, a preservative, essence and deionized water. The skin care product with the sunscreen and sun repair functions, provided by the invention, is reasonable in formula, stable in property, mild in effect and free from skin irritation and has the obvious sunscreen and sun repair functions under the synergistic action of the various effective components.
Description
Technical field
The invention belongs to cosmetic technical field, it is related to a kind of skin care item having sun-proof and after-sun function concurrently and its system
Preparation Method.
Background technology
In recent years, with the raising of people's health consciousness, ultraviolet has caused the extensive concern of people to the harm of skin.
A series of biological damages that ultraviolet produces to skin, not only have influence on the appearance whitening of people, or even threaten human body skin to be good for
Health.With the development of modern society, the rise of the stress-relieving activity such as people's out on tours, outdoor activities increase, and skin is exposed to purple
The time lengthening of UV radiation, along with environmental pollution leads to the destruction of atmospheric ozone layer, is radiated the ultraviolet of earth surface
More and more, therefore, protect the skin from ultraviolet injury and increasingly receive publicity in the modern life, sun-proof class cosmetics
Research and development become one of focus of cosmetics research and development.
Ultraviolet can be divided into long wave ultraviolet UVA (320nm-400nm), ultraviolet B radiation UVB (280nm- by wavelength
320nm) with short wave ultraviolet UVC (100nm-280nm).UVA can penetrate epiderm skin and most skin corium, oxide skin
In the melanin of reduced form and direct tanning, long duration of action can destroy the elastic fiberss in skin, cause skin light
Aging, skin is caused with serious infringement.UVB is weak compared with UVA to skin ability to function, and the overwhelming majority is absorbed by epidermis, on a small quantity
Through epidermis, the nucleic acid in skin epidermal cells or protein denaturation can be made, acute dermatitises erythema occur or burns.
Biology is sun-proof to be sun-proof at present and the research and development focus of after-sun class cosmetics, mainly uses in natural plants
Some compositions can absorb ultraviolet, removing or reduce the reactive oxygen free radical that ultraviolet radiation causes, thus stoping or reducing
Dermal tissue insult after Exposure to Sunlight, promotes day after-sun, plays indirect anti-sunlight function.Sun-proof interval big, the sensitization rate of biological sunscreen
Low, safe and effective, while sun-proof, also there is whitening and speckle dispelling, the anti-ageing effect of waiting for a long time, thus have broad application prospects.
Chinese patent CN 103405363 B discloses a kind of sun-proof repair combination, is extracted by Aloe extract, Radix Scutellariae
Thing, green tea extract, cordierite lotus extract, Vitamin E, silk peptide, nano level titanium dioxide, isomery hexadecane, Jojoba oil,
Squalane, glycerol, anhydrous sorbitol laurate, sorbitan monooleate, xanthan gum, essence, preservative and deionization
Water prepares, UVB and UVA can effectively be absorbed and Isolated Shield.But nano level physical sunscreen agent easily penetrates human body skin
Skin top layer penetrates into inside skin, health is had potentially hazardous, and meanwhile, research shows, nano-TiO2There is heredity
Toxicity, can cause the oxidative damage of DNA, so that DNA is untwisted and rupture, or even causes apoptosis and the necrosis of cell.
At present, the sun-proof class of the biology on market cosmetics, for improving sun-proof performance, how its sun-proof effective ingredient is by biological anti-
Shine agent and be combined composition with physical sunscreen agent or chemical sun, though it is potential to skin to reduce sun care preparationss to a certain extent
Zest, but because it still contains physical sunscreen agent or chemical sun, the comfortableness of product, stability and safety etc. are still
Have much room for improvement.
Content of the invention
It is an object of the invention to overcoming existing technological deficiency, providing and a kind of having sun-proof and after-sun function shield concurrently
Skin product and preparation method thereof.What the present invention provided has sun-proof and after-sun function skin care item concurrently, with sodium copper chlorophllin, dragon
Palpus dish extract, Lonicera confusa extract and Cortex Fraxini extract are main sun-prevention component, each composition synergism, sun-proof interval big,
Sun-proof result is notable.Meanwhile, the present invention do not contain physical sunscreen agent and chemical sun, action temperature and, no skin irritation, safety
Property high.Additionally, present invention offer has sun-proof and after-sun function skin care item concurrently and has significant whitening skin and preserving moisture effect, to purple
The acute dermatitises erythema that UV radiation causes has significant mitigation.
Technical scheme is as follows：
A kind of have sun-proof and after-sun function skin care item concurrently, by weight percentage, including following composition：Chlorophyll
Copper sodium 4-8%, cytokine complex liposome 1-2%, Thallus Gracilariae extract 3-5%, Lonicera confusa extract 2-4%, Cortex Fraxini
Extract 2-5%, glycyrrhizic acid dipotassium 0.05-0.2%, shea butter 5-10%, butanediol 5-10%, beta glucan 1-3%, thoroughly
Bright matter acid sodium 0.02-0.1%, xanthan gum 0.08-0.2%, trehalose 0.8-1.5%, hydrogenated jojoba oil 3-6%, squalane
2-5%, ring five dimethyl silicone polymer 2-5%, cetearyl glucoside 1-4%, cetearyl alcohol 1-3%, PEG-100 are hard
Fat acid ester 1-3%, tocopherol acetass 0.3-0.6%, bisabolol 0.1-0.4%, preservative 0.5-1%, essence 0.01-
0.05% and deionized water 25-63%；
Wherein, interleukin 12 and epidermal growth factor are contained in cytokine complex liposome.
Further, described cytokine complex liposome, counts by weight, including following component：Interleukin-
120.002-0.005 part, epidermal growth factor 0.001-0.002 part, Hulless oate protein zymolyte 5-15 part, hydrolecithin 80-
120 parts, sodium cholate 1-3 part and cholesterol 20-30 part.
Further, in described cytokine complex liposome, the preparation method of Hulless oate protein zymolyte includes walking as follows
Suddenly：
A. take Hulless oate flour, add the water of its quality 12-15 times amount, the NaOH solution being 1-2mol/L with concentration after mixing
Adjust pH to 10-12, be 42-48 DEG C in temperature, power is supersound process 40-60min under conditions of 200-250W, 3000-
4000r/min is centrifuged 20-25min, with 200 mesh filter-cloth filterings, takes supernatant, plus the HCl solution that concentration is 0.5-1mol/L is adjusted
Section pH value, to 4.0, stands 10-15min, and 3000-4000r/min is centrifuged 20-25min, takes precipitation, lyophilization, obtains Hulless oate egg
In vain；
B. take Hulless oate albumen, add water by solid-to-liquid ratio 8-12g/L, be stirring evenly and then adding into the alkalescence of total solution weight 8-12%
Protease, is 58-65 DEG C in temperature, and pH value is enzymolysis 4-6h under conditions of 8.5-9.0, and enzymolysis process keeps solution ph not
Become, enzymolysis terminates rear 100 DEG C of enzyme denaturing 5-8min, centrifuging and taking supernatant after cooling, concentrating under reduced pressure, is spray-dried, obtains final product Hulless oate egg
White zymolyte.
Further, the preparation method of described cytokine complex liposome comprises the steps：
1) take hydrolecithin, sodium cholate and cholesterol, add in dehydrated alcohol by solid-to-liquid ratio 2-5mg/mL, stirring is molten
Solution, obtains solution I；
2) take interleukin 12, epidermal growth factor and Hulless oate protein zymolyte, add by solid-to-liquid ratio 2-5mg/mL
PBS, stirring and dissolving, obtain solution II；
3) by step 1) described solution I and step 2) described solution II adds supercritical autoclave, is 30-40 in temperature
DEG C, pressure is 20-28MPa, CO2Flow is emulsifying 30-45min under conditions of 12-16L/h, and decompression separation emulsification product obtains carefully
Intracellular cytokine composite liposome body；Wherein, separation temperature is 30-40 DEG C, and separating pressure is 5-15MPa.
Further, in described cytokine complex lipid preparation, step 3) pH of described PBS is 6.8-7.0,
Concentration is 0.01-0.03mol/L.
Further, described preservative is glycerol caprylate, 1,2- pentanediol and Herba Lophatheri extract by weight 1:1-
2:0.3-0.6 compounds the preservative of composition, and wherein, Herba Lophatheri extract is grass henon bamboo leaf (Lophatherum
Gracile Bongn.) stem and leaf extract, purchased from Xi'an Bioisystech Co., Ltd of Tianrui.
Sun-proof and after-sun function the skin care item that have concurrently of present invention offer are extracted with sodium copper chlorophllin, Thallus Gracilariae
Thing, Lonicera confusa extract and Cortex Fraxini extract are main sun-prevention component, without physical sunscreen agent and chemical sun, action temperature
With, no skin irritation, safe.
Chlorophyll belongs to pyrrole derivatives species pigment, plays catalytic action in photosynthesis, has light absorbs containing one
The porphyrin ring of ability, in porphyrin ring, the conjugated system of singly-bound and double bond formation absorbs some visible light.Now there are some researches show, Ye Lv
Element has dual sun-proof function, can absorb and scatters ultraviolet simultaneously.Chlorophyll molecule is unstable in its natural state, easily decomposes
Inactivation, therefore the present invention is used sodium copper chlorophllin as sun-prevention component, improves the stability of product.
Thallus Gracilariae extract is the frond of Gracilaria tenuistipitata section Gracilaria tenuistipitata platymiscium Thallus Gracilariae (Gracilaria lemaneiformis)
Extract, purchased from Xi'an Bioisystech Co., Ltd of Tianrui, the composition such as protein containing algae red, mucoprotein and cholesterol, have moisturizing,
Antiinflammatory and sun-proof function.Lonicera confusa extract be caprifoliaceae plant Flos Lonicerae (Lonicera confusae DC.) alabastrum or
The extract of the flower that band is just opened, purchased from Xi'an Bioisystech Co., Ltd of Tianrui, containing volatile oil, chlorogenic acid, isochlorogenic acid, sweet-scented osmanthus
The compositions such as careless element, have the effects such as antiinflammatory, antipyretic, antioxidation, scavenging capacity oxygen-derived free radicals.Cortex Fraxini extract falls for Oleaceae
Leaf magaphanerophytes hardship manger's white beeswax (Fraxinus rhynchophlla Hance) or Fraxinus bungeana (Fraxinus bungeana
The extract of peel of stem DC.), purchased from Xi'an Bioisystech Co., Ltd of Tianrui, containing coumarin kind compound, to UVA and UVB
It is respectively provided with larger absorption.
Sodium copper chlorophllin, Thallus Gracilariae extract, Lonicera confusa extract and Cortex Fraxini extract compound as sunscreen application
In sun care preparationss, act on collaborative between each composition, the sun-proof ability of sun care preparationss and sun-proof effect, sun-proof result can be improved
Significantly.
UVB can cause the DNA break of horn cell, promotes horn cell that apoptosis occurs, the DNA damage of its induction is main
It is embodied in the substantial increase of intracellular cyclobutane pyrimidine dimer (CPDs), lead to the formation of a large amount of SBCs (SCs), make skin
The physical barriers of skin are subject to heavy damage.Research shows, interleukin 12 can effectively repair the skin DNA being led to by radiation
Damage, so that intracellular CPDs is greatly lowered, so that SBC number is reduced, recover impaired skin immunization state, increase skin
Moisture, thus have significant after-sun function.
Epidermal growth factor can effectively facilitate cell regeneration and tissue repair, accelerates the metabolism of cell, thus promoting
The synthesis of hyaluronic acid and collagen protein etc., thus reach the work repaired wound, eliminate mottle and pigmentation and skin moistening skin care
With.
Hulless oate protein zymolyte contains rich in protein and polypeptide moiety it is easy to be absorbed by the skin utilization, and skin is had
Preferably skin-moisturizing, skin and antioxidation.Hulless oate protein zymolyte is had with interleukin 12, epidermal growth factor just assists
Same-action, one side Hulless oate protein zymolyte can keep the abundant moisture of skin, such that it is able to good maintain interleukin-
12 and the biological activity of epidermal growth factor, another aspect three works in coordination with and can improve oozing of each effective ingredient of composite liposome body
Permeability, is conducive to the absorption to each active component for the skin, improves its bioavailability.
Glycyrrhizic acid dipotassium can prevent sensitive inflammation phenomenon during skin irriate, have antiinflammatory sedation to inflammation；Newborn fruit tree
Oil is absorbed by the skin, can nourishes rough skin, safeguard elastin, improve skin elasticity.Cytokine complex liposome and Radix Glycyrrhizae
Sour dipotassium, newborn fruit tree oil compound use, have significant nutrition skin, the work(promoting skin tissue regeneration, repairing skin injury
Effect.
The skin care item formula of sun-proof and after-sun function that what the present invention provided have concurrently rationally, stable in properties, action temperature and,
No skin irritation, and by the synergism of various effective ingredient, the effects such as have significantly sun-proof and after-sun.
Correspondingly, the present invention also provides a kind of system of the skin care item having sun-proof and after-sun function concurrently of the present invention
Preparation Method, comprises the steps：
S1：Take shea butter, hydrogenated jojoba oil, squalane, ring five dimethyl silicone polymer, cetearyl alcohol, PEG-
100 stearates, tocopherol acetass and bisabolol add in oil cauldron, are heated to 80-85 DEG C, and constant temperature stirs to complete
Dissolving, obtains material A；
S2：Extracting liquorice acid dipotassium, butanediol, hyaluronate sodium, xanthan gum, trehalose, cetearyl glucoside and go
Ionized water adds in aqueous phase pot, is heated to 80-85 DEG C, and constant temperature stirs to being completely dissolved the warmed-up emulsifying of rear suction
In pot, open stirring, by slow for material A suction emulsifying pot, carry out emulsifying, speed of agitator is 2500-3000r/min,
The emulsifying time is 5-10min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40-45 DEG C, add sodium copper chlorophllin, cytokine complex liposome, β-Portugal
Polysaccharide, Thallus Gracilariae extract, Lonicera confusa extract, Cortex Fraxini extract, preservative and essence, carry out second emulsifying, stir
Mix rotating speed is 500-700r/min, and the emulsifying time is 2-5min, and vacuum defoamation is cooled to room temperature, sampling Detection, qualified go out
Material, obtains final product.
Compared with prior art, the invention has the beneficial effects as follows：
1) what the present invention provided has sun-proof and after-sun function skin care item concurrently, is carried with sodium copper chlorophllin, Thallus Gracilariae
Thing, Lonicera confusa extract and Cortex Fraxini extract is taken to be main sun-prevention component, each composition synergism, sun-proof interval big, sun-proof effect
Fruit is notable, and meanwhile, the present invention does not contain physical sunscreen agent and chemical sun, action temperature and, no skin irritation, safe；
2) the skin care item formula of sun-proof and after-sun function that what the present invention provided have concurrently rationally, stable in properties, action temperature
With, no skin irritation, and by the synergism of various effective ingredient, the effects such as there is significantly sun-proof and after-sun；
3) preparation method of the skin care item having sun-proof and after-sun function concurrently that the present invention provides is simple, process stabilizing,
Convenient to carry out, can industrialized production, be conducive to popularization and application.
Specific embodiment
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following examples.This
In inventive embodiments if no special instructions, raw materials used it is conventional commercial product.
The preparation of embodiment 1 Hulless oate protein zymolyte
Comprise the steps：
A. take Hulless oate flour, add the water of its quality 12 times amount, adjusted with the NaOH solution that concentration is 1mol/L after mixing
PH to 10.5, is 45 DEG C in temperature, and power is supersound process 45min under conditions of 200W, and 4000r/min is centrifuged 20min, uses
200 mesh filter-cloth filterings, take supernatant, plus the HCl solution that concentration is 1mol/L adjusts pH value to 4.0, stands 10min, 4000r/
Min is centrifuged 20min, takes precipitation, lyophilization, obtains Hulless oate albumen；
B. take Hulless oate albumen, add water by solid-to-liquid ratio 10g/L, be stirring evenly and then adding into the basic protein of total solution weight 10%
Enzyme, is 60 DEG C in temperature, and pH value is enzymolysis 6h under conditions of 8.5, and enzymolysis process keeps solution ph constant, after enzymolysis terminates
100 DEG C of enzyme denaturing 5min, centrifuging and taking supernatant after cooling, concentrating under reduced pressure, it is spray-dried, obtain final product Hulless oate protein zymolyte.
The preparation method of embodiment 2 cytokine complex liposome
The present embodiment cytokine complex liposome, counts by weight, including following component：Interleukin-
120.003 parts, 0.001 part of epidermal growth factor, embodiment 1 preparation 10 parts of Hulless oate protein zymolyte, hydrolecithin 100
Part, 2 parts of sodium cholate and 25 parts of cholesterol.
Comprise the steps：
1) take hydrolecithin, sodium cholate and cholesterol, add in dehydrated alcohol by solid-to-liquid ratio 3mg/mL, stirring and dissolving,
Obtain solution I；
2) take interleukin 12, epidermal growth factor and Hulless oate protein zymolyte, add pH by solid-to-liquid ratio 3.5mg/mL
For 6.8, concentration is the PBS of 0.02mol/L, and stirring and dissolving obtains solution II；
3) by step 1) described solution I and step 2) described solution II adds supercritical autoclave, is 30 DEG C in temperature, pressure
Power is 25MPa, CO2Flow is emulsifying 40min under conditions of 15L/h, and decompression separation emulsification product obtains cytokine complex fat
Plastid；Wherein, separation temperature is 30 DEG C, and separating pressure is 8MPa.
Embodiment 3 has the preparation of the skin care item of sun-proof and after-sun function concurrently
The present embodiment has sun-proof and after-sun function skin care item concurrently, by weight percentage, is grouped into by following one-tenth：
Sodium copper chlorophllin 5%, the cytokine complex liposome 1% of embodiment 2 preparation, Thallus Gracilariae extract 3%, Flos Lonicerae extract
Thing 3%, Cortex Fraxini extract 5%, glycyrrhizic acid dipotassium 0.1%, shea butter 6%, butanediol 6%, beta glucan 2%, hyalomitome
Sour sodium 0.05%, xanthan gum 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, squalane 2%, ring five dimethyl silicone polymer
4%th, cetearyl glucoside 2%, cetearyl alcohol 1%, PEG-100 stearate 1.5%, tocopherol acetass 0.4%,
Bisabolol 0.1%, preservative 0.7%, essence 0.01% and deionized water 52.04%；Wherein, preservative is by glycerol octanoic acid
Ester, 1,2- pentanediol and Herba Lophatheri extract by weight 1:1:0.4 compounding composition.
Preparation method：
S1：Take shea butter, hydrogenated jojoba oil, squalane, ring five dimethyl silicone polymer, cetearyl alcohol, PEG-
100 stearates, tocopherol acetass and bisabolol add in oil cauldron, are heated to 85 DEG C, and constant temperature stirs to completely molten
Solution, obtains material A；
S2：Extracting liquorice acid dipotassium, butanediol, hyaluronate sodium, xanthan gum, trehalose, cetearyl glucoside and go
Ionized water adds in aqueous phase pot, is heated to 85 DEG C, and constant temperature stirs to being completely dissolved the warmed-up emulsifying pot of rear suction
In, open stirring, by slow for material A suction emulsifying pot, carry out emulsifying, speed of agitator is 3000r/min, emulsifying
Time is 8min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40 DEG C, sodium copper chlorophllin, cytokine complex liposome, β-Portugal is added to gather
Sugar, Thallus Gracilariae extract, Lonicera confusa extract, Cortex Fraxini extract, preservative and essence, carry out second emulsifying, stirring
Rotating speed is 600r/min, and the emulsifying time is 4min, and vacuum defoamation is cooled to room temperature, sampling Detection, qualified discharging, obtains final product.
Embodiment 4 has the preparation of the skin care item of sun-proof and after-sun function concurrently
The present embodiment has sun-proof and after-sun function skin care item concurrently, by weight percentage, is grouped into by following one-tenth：
Sodium copper chlorophllin 6%, the cytokine complex liposome 1.5% of embodiment 2 preparation, Thallus Gracilariae extract 4%, Flos Lonicerae carry
Take thing 3%, Cortex Fraxini extract 4%, glycyrrhizic acid dipotassium 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthan gum 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, squalane 3%, ring five polydimethylsiloxanes
Alkane 3%, cetearyl glucoside 2%, cetearyl alcohol 2%, PEG-100 stearate 2%, tocopherol acetass 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, described preservative is by caprylic
Acid esters, 1,2- pentanediol and Herba Lophatheri extract by weight 1:2:0.3 compounding composition.
Preparation method is with embodiment 3.
Comparative example 1
1) prepare cytokine complex liposome：Count by weight, including following component：Interleukin 12 0.003
Part, 0.001 part of epidermal growth factor, 100 parts of hydrolecithin, 2 parts of sodium cholate and 25 parts of cholesterol.
The preparation method of cytokine complex liposome is similar to embodiment 2.
2) preparation has sun-proof and after-sun function skin care item concurrently：By weight percentage, it is grouped into by following one-tenth：Leaf
Verdazulene copper sodium 6%, the cytokine complex liposome 1.5% of this comparative example preparation, Thallus Gracilariae extract 4%, Flos Lonicerae carry
Take thing 3%, Cortex Fraxini extract 4%, glycyrrhizic acid dipotassium 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthan gum 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, squalane 3%, ring five polydimethylsiloxanes
Alkane 3%, cetearyl glucoside 2%, cetearyl alcohol 2%, PEG-100 stearate 2%, tocopherol acetass 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, described preservative is by caprylic
Acid esters, 1,2- pentanediol and Herba Lophatheri extract by weight 1:2:0.3 compounding composition.
Preparation method is similar to embodiment 4.
Comparative example 1 is with the difference of embodiment 4, does not contain Hulless oate proteolysiss in described cytokine complex liposome
Thing.
Comparative example 2
This comparative example has sun-proof and after-sun function skin care item concurrently, by weight percentage, is grouped into by following one-tenth：
Sodium copper chlorophllin 6%, the cytokine complex liposome 1.5% of embodiment 2 preparation, Thallus Gracilariae extract 4%, Flos Lonicerae carry
Take thing 3%, Radix Scutellariae extract 4%, glycyrrhizic acid dipotassium 0.12%, shea butter 8%, butanediol 6%, beta glucan 2%, transparent
Matter acid sodium 0.05%, xanthan gum 0.1%, trehalose 1%, hydrogenated jojoba oil 4%, squalane 3%, ring five polydimethylsiloxanes
Alkane 3%, cetearyl glucoside 2%, cetearyl alcohol 2%, PEG-100 stearate 2%, tocopherol acetass 0.5%,
Bisabolol 0.2%, preservative 0.8%, essence 0.01% and deionized water 46.72%；Wherein, described preservative is by caprylic
Acid esters, 1,2- pentanediol and Herba Lophatheri extract by weight 1:2:0.3 compounding composition.Preparation method is similar to embodiment 9.
Comparative example 2 is with the difference of embodiment 4, replaces Cortex Fraxini extract with Radix Scutellariae extract.
Test example one human skin patch
With reference to Ministry of Public Health《Cosmetics health specification》In (version in 2007) related request of " human skin patch " and
Method carries out " human body skin enclosed type patch test ".
1st, given the test agent：What embodiment of the present invention 3-4, comparative example 1-2 prepared has sun-proof and after-sun function concurrently
Skin care item.
2nd, test method：Select 140 volunteers meeting inclusion criteria to participate in test, be randomly divided into 4 groups, every group 35
People.Try device from qualified speckle, 0.025g given the test agent is added in speckle examination device, and with non-stimulated adhesive tape cloth, speckle examination device is sticked
In the forearm song side of trial volunteer, it is allowed to equably be pasted on skin with the light pressure of palm, after 24h, removes the examination of tested material speckle
Device, observes dermoreaction after 30min, 2h, 4h, 24h and 48h, according to《Skin adverse reaction grade scale table》Record
Reaction result.
3rd, result of the test：Embodiment 3-4, the result of the test of all trial volunteers of comparative example 1-2 group are negative findings,
Thus can determine that, what embodiment of the present invention 3-4, comparative example 1-2 prepared has sun-proof and after-sun function skin care item concurrently
No skin adverse reaction.It is safe that what the present invention provided has sun-proof and after-sun function skin care item concurrently.
The sun-proof performance test of test example two
1st, SPF (sun protection factor) (spf value) measures
With reference to Ministry of Public Health《Cosmetics health specification》In (version in 2007), " sun care preparationss SPF (sun protection factor) (spf value) measures
The related request of method " and assay method are carried out.Given the test agent be embodiment of the present invention 3-4, comparative example 1-2 prepare simultaneous
Have sun-proof and after-sun function skin care item.Choose 60 trial volunteers to be tested, be randomly divided into 4 groups, every group of 15 people.
2nd, long wave ultraviolet protection index (PFA value) measures
With reference to Ministry of Public Health《Cosmetics health specification》" sun care preparationss long wave ultraviolet protection index in (version in 2007)
The related request of (PFA value) assay method " and assay method are carried out.Given the test agent is embodiment of the present invention 3-4, comparative example 1-2
Prepare has sun-proof and after-sun function skin care item concurrently.Choose 60 trial volunteers to be tested, be randomly divided into 4
Group, every group of 15 people.
3rd, test result：It is shown in Table 1.
Table 1 present invention has the sun-proof the performance test results of sun-proof and after-sun function skin care item concurrently
| Group | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 |
| Spf value | 28 | 30 | 20 | 18 |
| PFA value | 8 | 10 | 3 | 4 |
| PA grade | PA+++ | PA+++ | PA+ | PA++ |
Have sun-proof and after-sun work(from what the test result of table 1 can be seen that embodiment of the present invention 3-4 prepares concurrently
More than 25, PA grade all reaches PA+++ to the skin care item spf value of energy, and what present invention offer was described has sun-proof and after-sun concurrently
The skin care item of function are respectively provided with good absorption and barrier property to UVB and UVA, and sun-proof result is notable.It is simultaneous that the present invention provides
Have sun-proof and after-sun function skin care item sun-proof result and be substantially better than comparative example group.
Test example three sensory evaluation
1st, given the test agent：What embodiment of the present invention 3-4, comparative example 1-2 prepared has sun-proof and after-sun function concurrently
Skin care item.
2nd, test method：Choose 200 skin healths and the women trial volunteer of no skin allergy history participates in test, will
All trial volunteers are randomly divided into 4 groups, every group of 50 people.Each group trial volunteer tries out above-mentioned given the test agent respectively, continuously makes
With one month, try out after terminating, the using effect such as this self assessment moisturizing of each trial volunteer, whitening, sun-proof, overall assessment is done
Sensory evaluation, according to using effect in a 0-10/marking, 9-10 is divided into very well, and 7-8 is divided into preferably, and 5-6 is divided into typically, 3-
4 are divided into poor, and 1-2 is divided into very poor, averages.
3rd, result of the test：It is shown in Table 2.
Table 2 present invention has sun-proof and after-sun function skin care item effect assessment concurrently
| Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | |
| Sun-proof result | 8.5 | 8.9 | 7.2 | 6.8 |
| Moistening effect | 8.2 | 8.6 | 5.7 | 7.2 |
| Whitening effect | 8.5 | 8.7 | 6.8 | 7.1 |
| After-sun effect | 8.6 | 8.8 | 5.6 | 6.8 |
| Salubrious no greasy feeling | 8.4 | 8.6 | 7.5 | 7.4 |
| Assimilation effect | 8.2 | 8.5 | 6.8 | 7.3 |
| Overall assessment | 8.2 | 8.5 | 6.4 | 6.9 |
As can be known from the results of Table 2, the skin care item having sun-proof and after-sun function concurrently of embodiment of the present invention 3-4 preparation
Degree of recognition is high, and using effect is evaluated high.What the present invention prepared have concurrently sun-proof and after-sun function skin care item sun-proof and
After-sun effect is significant, after use, skin clearly no greasy feeling, good absorbing effect.After continuously using one month, aspiration is tested
The phenomenons such as person's xerosis cutiss, epidermal pigment calmness are obviously improved.In process of the test, trial volunteer all no allergy or other skins
Untoward reaction.Contrast having concurrently of preparing of 1-2 is sun-proof and skin care item using effect of after-sun function is not so good as embodiment 3-4
Prepare has sun-proof and after-sun function skin care item concurrently.
Above content is to further describe it is impossible to assert with reference to specific preferred implementation is made for the present invention
Being embodied as of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of present inventive concept, some simple deduction or replace can also be made, all should be considered as belonging to the present invention's
Protection domain.
Claims (7)
1. a kind of skin care item having sun-proof and after-sun function concurrently it is characterised in that described skin care item by weight percentage,
Including following composition：Sodium copper chlorophllin 4-8%, cytokine complex liposome 1-2%, Thallus Gracilariae extract 3-5%, mountain silver
Flower extract 2-4%, Cortex Fraxini extract 2-5%, glycyrrhizic acid dipotassium 0.05-0.2%, shea butter 5-10%, butanediol 5-
10%th, beta glucan 1-3%, hyaluronate sodium 0.02-0.1%, xanthan gum 0.08-0.2%, trehalose 0.8-1.5%, hydrogenation
Jojoba oil 3-6%, squalane 2-5%, ring five dimethyl silicone polymer 2-5%, cetearyl glucoside 1-4%, spermaceti
Stearyl alcohol 1-3%, PEG-100 stearate 1-3%, tocopherol acetass 0.3-0.6%, bisabolol 0.1-0.4%, anti-corrosion
Agent 0.5-1%, essence 0.01-0.05% and deionized water 25-63%；
Wherein, interleukin 12 and epidermal growth factor are contained in cytokine complex liposome.
2. have the skin care item of sun-proof and after-sun function as claimed in claim 1 concurrently it is characterised in that described cytokine
Complex liposome, counts by weight, including following component：Interleukin 12 0.002-0.005 part, epidermal growth factor
0.001-0.002 part, Hulless oate protein zymolyte 5-15 part, hydrolecithin 80-120 part, sodium cholate 1-3 part and cholesterol 20-
30 parts.
3. have the skin care item of sun-proof and after-sun function as claimed in claim 2 concurrently it is characterised in that described cytokine
In complex liposome, the preparation method of Hulless oate protein zymolyte comprises the steps：
A. take Hulless oate flour, add the water of its quality 12-15 times amount, adjusted with the NaOH solution that concentration is 1-2mol/L after mixing
PH to 10-12, is 42-48 DEG C in temperature, and power is supersound process 40-60min under conditions of 200-250W, 3000-4000r/
Min is centrifuged 20-25min, with 200 mesh filter-cloth filterings, takes supernatant, plus the HCl solution that concentration is 0.5-1mol/L adjusts pH value
To 4.0, stand 10-15min, 3000-4000r/min is centrifuged 20-25min, takes precipitation, lyophilization, obtains Hulless oate albumen；
B. take Hulless oate albumen, add water by solid-to-liquid ratio 8-12g/L, be stirring evenly and then adding into the basic protein of total solution weight 8-12%
Enzyme, is 58-65 DEG C in temperature, and pH value is enzymolysis 4-6h under conditions of 8.5-9.0, and enzymolysis process keeps solution ph constant, enzyme
Solution terminates rear 100 DEG C of enzyme denaturing 5-8min, centrifuging and taking supernatant after cooling, concentrating under reduced pressure, is spray-dried, obtains final product Hulless oate proteolysiss
Thing.
4. have the skin care item of sun-proof and after-sun function as claimed in claim 2 concurrently it is characterised in that described cytokine
The preparation method of complex liposome comprises the steps：
1) take hydrolecithin, sodium cholate and cholesterol, add in dehydrated alcohol by solid-to-liquid ratio 2-5mg/mL, stirring and dissolving, obtain
Solution I；
2) take interleukin 12, epidermal growth factor and Hulless oate protein zymolyte, add PBS by solid-to-liquid ratio 2-5mg/mL, stir
Mix dissolving, obtain solution II；
3) by step 1) described solution I and step 2) described solution II adds supercritical autoclave, is 30-40 DEG C in temperature, pressure
Power is 20-28MPa, CO2Flow be 12-16L/h under conditions of emulsifying 30-45min, decompression separation emulsification product, obtain cell because
Sub- composite liposome body；Wherein, separation temperature is 30-40 DEG C, and separating pressure is 5-15MPa.
5. have the skin care item of sun-proof and after-sun function as claimed in claim 4 concurrently it is characterised in that described cytokine is multiple
Close method for preparing lipidosome in, step 3) described PBS pH be 6.8-7.0, concentration be 0.01-0.03mol/L.
6. the skin care item having sun-proof and after-sun function as claimed in claim 1 concurrently are it is characterised in that described preservative is
Glycerol caprylate, 1,2- pentanediol and Herba Lophatheri extract by weight 1:1-2:0.3-0.6 compounds the preservative of composition.
7. the preparation method of the described skin care item having sun-proof and after-sun function concurrently as arbitrary in claim 1-6, its feature
It is, comprise the steps：
S1：Take shea butter, hydrogenated jojoba oil, squalane, ring five dimethyl silicone polymer, cetearyl alcohol, PEG-100 hard
Fat acid ester, tocopherol acetass and bisabolol add in oil cauldron, are heated to 80-85 DEG C, and constant temperature stirs to being completely dissolved,
Obtain material A；
S2：Extracting liquorice acid dipotassium, butanediol, hyaluronate sodium, xanthan gum, trehalose, cetearyl glucoside and deionization
Water adds in aqueous phase pot, is heated to 80-85 DEG C, and constant temperature stirs to being completely dissolved the warmed-up emulsifying pot of rear suction
In, open stirring, by slow for material A suction emulsifying pot, carry out emulsifying, speed of agitator is 2500-3000r/min, all
Matter emulsification times are 5-10min, and vacuum defoamation obtains emulsion I；
S3：When thing I to be emulsified is cooled to 40-45 DEG C, add sodium copper chlorophllin, cytokine complex liposome, beta glucan,
Thallus Gracilariae extract, Lonicera confusa extract, Cortex Fraxini extract, preservative and essence, carry out second emulsifying, speed of agitator
For 500-700r/min, the emulsifying time is 2-5min, vacuum defoamation, is cooled to room temperature, sampling Detection, qualified discharging, that is,
?.
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