CN111920724A

CN111920724A - Skin care composition for repairing sensitive muscle

Info

Publication number: CN111920724A
Application number: CN202010975236.2A
Authority: CN
Inventors: 何备战; 刘木水
Original assignee: Guangzhou Hejiarunyan Pharmaceutical Co ltd
Current assignee: Guangzhou Hejiarunyan Pharmaceutical Co ltd
Priority date: 2020-09-16
Filing date: 2020-09-16
Publication date: 2020-11-13

Abstract

The invention belongs to the technical field of cosmetics and discloses a skin care composition for repairing sensitive muscles. The skin care composition for repairing sensitive muscles provided by the invention comprises a kava pepper extract, a lonicera confusa extract, a moringa oleifera seed extract, a corydalis yanhusuo root extract, an andrographis paniculata extract, a goldthread root extract, a scutellaria baicalensis root extract and a houttuynia cordata extract. The invention has the advantages that the kava pepper extract and the corydalis yanhusuo extract are used for calming the skin, the goldthread extract and the scutellaria extract are combined for antibiosis, antiphlogosis and allergy inhibition, the houttuynia cordata extract and the lonicera confusa extract are used for detoxification and antibiosis, the symptoms such as vasodilatation, skin itch and red swelling caused by anaphylactic reaction are rapidly relieved, meanwhile, the moringa pterospifolia seed extract is used for moisturizing, the water balance of allergic skin is ensured, in addition, the andrographis paniculata extract is used for improving the skin immunity, the skin barrier is repaired from a deep level, and the skin tolerance and self-repairing capability are improved.

Description

Skin care composition for repairing sensitive muscle

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a skin care composition for repairing sensitive muscles.

Background

Sensitive skin is a special skin type which shows excessive response to external stimuli and is easy to have objective symptoms such as erythema, pimples, desquamation, telangiectasia and the like. The skin barrier serves as the outermost layer of the epidermis and the bottommost layer of the stratum corneum, and serves to block the invasion of irritants, drugs, and the like. The integrity of the stratum corneum is dependent on the keratinizing particles, which can hold stratum corneum cells together. In normal skin environment, with the continuous maturation and differentiation of keratinocytes, keratinized particles are gradually decomposed and shed by protease, and after the keratinized particles are not fixed, keratinocytes gradually shed through the epidermis, and new keratinocytes are continuously formed to fill the shed keratinocytes. However, after the skin barrier is damaged, the formation of new keratinocytes is hindered, the stratum corneum becomes thinner, exogenous irritants are more likely to invade the skin, the immunoreaction is promoted to be excessive, cytokines induce local immunoreaction on the skin surface, the afferent nerves are changed, the skin barrier function is weakened, and objective symptoms such as erythema, pimple, desquamation and telangiectasia are further caused. The process is induced by a number of factors, including ultraviolet radiation, drugs, and cosmetics. In daily life, these induction factors cannot be avoided one by one, so that it is necessary to develop cosmetics suitable for sensitive skin.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a skin care composition for repairing sensitive muscles, which can effectively relieve the symptoms of facial allergy, deeply repair skin barriers and improve the tolerance capability of the skin.

The invention provides a skin care composition for repairing sensitive muscles, which comprises a kava extract, a lonicera confusa extract, a moringa oleifera seed extract, a corydalis yanhusuo root extract, an andrographis paniculata extract, a goldthread root extract, a scutellaria baicalensis root extract and a houttuynia cordata extract.

Piper METHYSTICUM (Piper METHYSTICUM) extract is Piper METHYSTICUM leaf/root/stem extract, Piper METHYSTICUM Forst is Piperaceae perennial upright Piper medicinal plant, is produced in Pacific island, root and rhizome, and has liposoluble resin as effective component for regulating insomnia and psychological problems such as pressure, anxiety, depression, etc. It has been shown that dihydrokavain and dihydrokavain contained in the kava leaf/root/stem extract have a significant muscle relaxant effect and their analgesic effect is superior to aspirin. Mainly contains kavalactone, kavalactone and the like. Specifically 6 kava lactones, namely kavain, dihydrokavain, methoxykavain and desmethoxykavain. In addition, the skin care product also contains volatile oil, piperine, crude fat, various amide compounds, piperine, feruloyl piperidines, piperone and the like, has good antioxidant effect, removes the internal wastes of the skin, and helps to remove aging substances which are easy to induce various skin problems. The penetration simulation test shows that the product has penetration promoting effect, and can be used as penetration enhancer for cosmetics.

Flos Lonicerae (LONICERA CONFUSA) extract: sweet in nature and taste and cold in nature. It enters lung, heart and stomach. Clear heat and remove toxicity, disperse wind-heat. Can be used for treating carbuncle, swelling, sore, pharyngitis, erysipelas, toxic heat, dysentery, wind-heat type common cold, and warm diseases. Flos Lonicerae contains large amount of chlorogenic acid and luteoloside, chlorogenic acid has good scavenging effect on free radicals, and has wide antibacterial effect, and luteoloside has antibacterial, antiinflammatory, antipyretic and analgesic effects.

MORINGA pterocarpa (MORINGA PTERYGOSPERMA) seed extract: the skin care product mainly has the effects of moisturizing agent, antioxidant and no acne caused by the moringa oleifera seed extract. Has effects in scavenging free radicals, resisting aging, and acting as antioxidant; can supplement water, and can be used as humectant in cosmetic.

Rhizoma CORYDALIS (CORYDALIS TURTSCHININOVII) root extract: rhizoma corydalis is also called as flos Caraganae Sinicae, herba Lobeliae chinensis and rhizoma corydalis, and its extract contains corydalis A, B and C. Has analgesic, tranquilizing and anti-startle effects, and can be used for regulating skin.

Extract of Andrographis PANICULATA (Andrographis PANICULATA): has effects in clearing away heat and toxic materials, relieving inflammation, and relieving swelling and pain. Modern medicine considers that the andrographis paniculata extract can improve the capability of peripheral cells to phagocytize bacteria, and meanwhile, the andrographis paniculata root total flavonoids can also participate in regulating cardiovascular and blood systems.

Extract of goldthread root (COPTIS CHINENSIS): the goldthread root is a common traditional Chinese medicine in China, can treat skin inflammation, eczema, wound healing and the like, and has strong antibacterial property; the extract of Japanese goldthread has effects of promoting collagen production and activating skin, and can be used in antiaging cosmetic in combination with their antioxidant effects; the Coptidis rhizoma extract has effects of inhibiting allergy, whitening skin, and keeping moisture.

Extract of SCUTELLARIA root (scutelaria BAICALENSIS) root: including baicalin (baicailin), wogonin (wogonoside), baicalein (baicalein), and wogonin (wogonin). The scutellaria and the effective components thereof have wide pharmacological actions, such as anti-inflammatory, anti-oxidation, anti-tumor, immunoregulation and the like, and especially have the most obvious antibacterial/antifungal action.

HOUTTUYNIA CORDATA (HOUTTUYNIA cordia) extract: contains volatile oil, quercetin, rutin, etc., and has effects of clearing away heat and toxic materials, and removing carbuncle and pus. The main effect is skin conditioner, and the houttuynia cordata extract has no pox-causing property.

Preferably, the skin care composition for repairing sensitive muscles is mainly prepared from, by mass, 1-2% of a piper wallichii extract, 0.5-1.5% of a lonicera confusa extract, 0.8-1.6% of a pterospermum pterocarpum seed extract, 0.8-1.6% of a corydalis yanhusuo root extract, 1-2% of an andrographis paniculata extract, 0.8-2% of a goldthread root extract, 0.8-2% of a scutellaria baicalensis root extract, 0.5-1.5% of a houttuynia cordata extract, and the balance of cosmetic adjuvants.

Preferably, the cosmetic auxiliary material of the skin care composition for repairing sensitive muscles comprises water and propylene glycol.

Preferably, the skin care composition for repairing sensitive muscles is mainly prepared from, by mass, 1-2% of piper wallichii extract, 0.5-1.5% of lonicera confusa extract, 0.8-1.6% of moringa oleifera seed extract, 0.8-1.6% of corydalis yanhusuo root extract, 1-2% of andrographis paniculata extract, 0.8-2% of coptis chinensis extract, 0.8-2% of scutellaria baicalensis root extract, 0.5-1.5% of houttuynia cordata extract, and the balance of water.

Preferably, the skin care composition for repairing sensitive muscles further comprises kiwi fruit extract.

Preferably, in the skin care composition for repairing sensitive muscles, the kiwi fruit extract is an alcohol extract of kiwi fruit.

Preferably, the skin care composition for repairing sensitive muscles further comprises haematococcus pluvialis extract.

Preferably, in the skin care composition for repairing sensitive muscles, the haematococcus pluvialis extract is a supercritical CO2 extract.

Preferably, the weight ratio of the kiwi fruit extract to the haematococcus pluvialis extract is 1 (0.4-0.6).

Preferably, in the skin care composition for repairing sensitive muscles, the weight ratio of the kiwi fruit extract to the haematococcus pluvialis extract is 1: 0.5.

The invention has the beneficial effects that:

the skin care composition for repairing sensitive muscles, provided by the invention, calms the skin through the kava extract and the corydalis yanhusuo extract, combines the goldthread extract and the scutellaria extract to resist bacteria, diminish inflammation and inhibit allergy, and the houttuynia cordata extract and the lonicera confusa extract to detoxify and resist bacteria, quickly relieves symptoms of vasodilatation, skin itch, skin red swelling and the like caused by anaphylactic reaction, meanwhile, the moringa oleifera seed extract is used for moisturizing, so that the water balance of allergic skin is guaranteed, in addition, the andrographis paniculata extract is used for improving the immunity of the skin, the skin barrier is deeply repaired, the tolerance capability and the self-repairing capability of the skin are improved, and on the whole, the skin care composition for repairing the sensitive skin provided by the invention has good skin feel and mild texture, the skin care cream has the advantages of good safety, no toxic or side effect and no anaphylactic reaction, has good anti-anaphylactic effect, and can also deeply repair damaged skin barriers and thoroughly solve the problem of allergic skin. In addition, the kiwi fruit extract and the haematococcus pluvialis powder extract are added, so that the allergic symptoms can be further quickened and relieved, meanwhile, the tolerance capability of the skin can be further improved on the basis, and allergy can not occur even when the traditional product is used.

Drawings

FIG. 1 is a graph of the results of a skin irritation test for a skin care composition provided by the present invention for repairing sensitive muscles;

FIG. 2 is a graph of the results of clinical use of a skin care composition for repairing sensitive muscles provided by the present invention for 0 day;

FIG. 3 is a graph of the results of 20 days of clinical use of the skin care composition for repairing sensitive muscles provided by the present invention;

FIG. 4 is a graph of the results of a 40-day clinical use of a skin care composition for repairing sensitive muscles provided by the present invention;

fig. 5 is a graph showing the results of the skin care composition for repairing sensitive muscles according to the present invention after being clinically used for 60 days.

Detailed Description

The present invention is further illustrated below with reference to specific examples.

Example 1

This example is directed to the preparation of a skin care composition for repairing sensitive muscles, comprising the steps of:

(1) accurately measuring a kava extract, a lonicera confusa extract, a moringa oleifera seed extract, a corydalis yanhusuo root extract, an andrographis paniculata extract, a goldthread root extract, a scutellaria baicalensis root extract and a houttuynia cordata extract;

(2) respectively dissolving the raw materials weighed in the step (1) in propylene glycol, and fully dissolving the raw materials to obtain propylene glycol solutions of the raw materials;

(3) and (3) uniformly mixing water and the rest propylene glycol, heating to 40-45 ℃, adding the propylene glycol solution of each raw material in the step (2), and fully and uniformly mixing to obtain the skin care composition for repairing sensitive muscles.

The dosage of each raw material in the skin care composition for repairing sensitive muscle provided in this example is shown in table 1:

TABLE 1

Name of raw materials	By weight%
		Water (W)	82
Propylene glycol	8
		Piper methysticum extract	1
Flos Lonicerae extract	0.5
		Moringa oleifera seed extract	1.2
Corydalis yanhusuo root extract	1.6
		Andrographis paniculata extract	2
Extract of goldthread root	1.4
		Scutellaria root extract	0.8
Houttuynia cordata extract	1.5

Example 2

The dosage of each raw material in the skin care composition for repairing sensitive muscle provided in this example is shown in table 2:

TABLE 2

Name of raw materials	By weight%
		Water (W)	81
Propylene glycol	9
		Piper methysticum extract	1.5
Flos Lonicerae extract	1.5
		Moringa oleifera seed extract	1.6
Rhizoma corydalis DecumbentisFetching article	1.1
		Andrographis paniculata extract	1.2
Extract of goldthread root	1.5
		Scutellaria root extract	1.1
Houttuynia cordata extract	0.5

Example 3

The dosage of each raw material in the skin care composition for repairing sensitive muscle provided in this example is shown in table 3:

TABLE 3

Name of raw materials	By weight%
		Water (W)	81
Propylene glycol	9
		Piper methysticum extract	1.8
Flos Lonicerae extract	1.2
		Moringa oleifera seed extract	1.4
Corydalis yanhusuo root extract	0.8
		Andrographis paniculata extract	1.5
Extract of goldthread root	1.2
		Scutellaria root extract	1.3
Houttuynia cordata extract	0.8

Example 4

The dosage of each raw material in the skin care composition for repairing sensitive muscle provided in this example is shown in table 4:

TABLE 4

Name of raw materials	By weight%
		Water (W)	81
Propylene glycol	9
		Piper methysticum extract	1.2
Flos Lonicerae extract	0.8
		Moringa oleifera seed extract	0.8
Corydalis yanhusuo root extract	1.4
		Andrographis paniculata extract	1
Extract of goldthread root	2
		Scutellaria root extract	1.6
Houttuynia cordata extract	1.2

Example 5

The dosage of each raw material in the skin care composition for repairing sensitive muscle provided in this example is shown in table 5:

TABLE 5

Name of raw materials	By weight%
		Water (W)	80
Propylene glycol	10
		Piper methysticum extract	2
Flos Lonicerae extract	1
		Moringa oleifera seed extract	1.6
Corydalis yanhusuo root extract	0.6
		Andrographis paniculata extract	1
Extract of goldthread root	0.8
		Scutellaria root extract	2
Houttuynia cordata extract	1

Example 6

The purpose of this example was to prepare a skin care composition for repairing sensitive muscles.

(1) Weighing kiwi fruit powder, soaking in ethanol to soften the kiwi fruit powder, and evaporating under reduced pressure by using a rotary freezing evaporator to obtain powder, namely the kiwi fruit extract;

(2) weighing haematococcus pluvialis powder, placing the haematococcus pluvialis powder into an extraction kettle, statically extracting for 2 hours, dynamically extracting for 2.5 hours, collecting a supercritical CO2 extract at the temperature of 65 ℃ and under the conditions that the flow rate of CO2 in a supercritical state is 15L/h, the using amount of an entrainer during extraction is 1.2mL/min, the pressure is 40MPa, and vacuum rotary evaporation and concentration are performed, and nitrogen purging is performed to remove an ethanol entrainer, so that the haematococcus pluvialis powder extract is obtained;

(3) mixing the kiwi fruit extract and the haematococcus pluvialis powder extract respectively according to the weight percentage of 1:0.4, 1:0.5 and 1:0.6, dissolving the mixture in propylene glycol to enable the sum of the weight percentages of the kiwi fruit extract and the haematococcus pluvialis powder extract in the finally obtained skin care composition to be 1%, adding the raw materials in the mixture ratio in the embodiment 3, and mixing the mixture uniformly to obtain the skin care composition for repairing sensitive muscles, wherein the skin care composition further comprises 1.8% of kava extract, 1.2% of lonicera confusa extract, 1.4% of moringa oleifera seed extract, 0.8% of corydalis yanhusuo root extract, 1.5% of andrographis paniculata extract, 1.2% of coptis chinensis extract, 1.3% of scutellaria baicalensis root extract, 0.8% of houttuynia cordata extract and 9.

Examples of effects

The purpose of this effect example was to verify the antiallergic function of the skin care compositions for repairing sensitive muscles in examples 1 to 6.

1. Skin irritation test

Removing hair from the back of the experimental mouse and exposing the skin to about 9cm²And randomly dividing the skin care composition into 9 groups, numbering 1-9, and taking 1-8 groups as experimental groups, wherein 1-5 groups are coated with the skin care composition for repairing sensitive muscles provided in the examples 1-5, 6-8 groups are sequentially coated with the skin care composition for repairing sensitive muscles obtained in the example 6 according to the ratio of 1:0.4, 1:0.5 and 1:0.6, and 9 groups are positive control groups (the allergic medicament is 2, 4-dinitrochlorobenzene). The test is carried out for 14 days, the erythema condition of the smearing part is observed every day,wherein, the score of no erythema is 0, the score of mild erythema (barely visible) is 1, the score of moderate erythema (obviously visible) is 2, and the score of severe erythema is 3. The results are shown in FIG. 1. As can be seen from fig. 1, the skin care composition for repairing sensitive muscles provided by the present invention is non-irritating to the skin and free from allergic reactions such as erythema edema.

2. Clinical use

Grouping according to the following rules: group a, pseudo-healthy, with normal skin barrier function and no inflammatory changes, occasional history of allergy, with allergy in approximately three months but no allergy in approximately one month; group B, the group with reduced skin barrier function, has anaphylactic reaction in nearly one month, is easy to be allergic at ordinary times, is not allergic when being tested, and has limited choice of skin care products at ordinary times; group C, inflammatory and reduced barrier function group, being in allergic phase;

sensitive skin: selecting 90 sensitive skin subjects, and grouping according to the rule, wherein the A group comprises 60 persons in the pseudo-healthy group; group B, 32 persons with reduced skin barrier function; group C, inflammatory group and reduced barrier function group 15. The skin care composition for repairing the sensitive muscles obtained in example 6 is coated on 1-3 groups of the skin care composition for repairing the sensitive muscles obtained in example 6 according to the ratio of 1:0.4, 1:0.5 and 1:0.6, the skin care composition for repairing the sensitive muscles provided in example 3 is coated on 4 groups of the skin care composition, the coating method of each group is the same, the skin care composition is uniformly coated on the face 2 times a day and is continuously used for 2 months, the skin health condition of each group of testees is observed before coating, after coating for 20 days, 40 days and 60 days by adopting a noninvasive skin tester, and after 30 days, conventional products on the market are normally selected. As shown in fig. 2 to 5, the skin care composition for repairing sensitive muscles provided by the present invention has good antiallergic effect, and the allergic rate is greatly reduced after the use of conventional products on the market starts in 30 days, which indicates that the skin care composition for repairing sensitive muscles provided by the present invention can not only resist allergy in a short period, maintain the stability of skin, but also adjust the barrier of skin, and solve the allergic root cause from deep level, and is particularly suitable for sensitive muscles.

In conclusion, the skin care composition for repairing sensitive muscles provided by the invention calms the skin through the kava extract and the corydalis yanhusuo extract, combines the coptis extract and the scutellaria extract to resist bacteria, diminish inflammation and inhibit allergy, and the houttuynia extract and the lonicera confusa extract to detoxify and resist bacteria, quickly relieves symptoms such as vasodilatation, skin itch, red swelling and the like caused by anaphylactic reaction, simultaneously uses the moringa oleifera seed extract to replenish water and preserve moisture to ensure the water balance of the allergic skin, and uses the andrographis paniculata extract to improve the immunity of the skin, repair skin barriers from deep levels, improve the tolerance capability and self-repair capability of the skin, and overall, the skin care composition for repairing sensitive muscles provided by the invention has good skin feel, mild texture, good safety, no toxic or side effect and anaphylactic reaction, not only has good antiallergic effect, but also can repair damaged skin barriers from deep levels, thoroughly solves the problem of allergic skin. In addition, the kiwi fruit extract and the haematococcus pluvialis powder extract are added, so that the allergic symptoms can be further quickened and relieved, meanwhile, the tolerance capability of the skin can be further improved on the basis, and allergy can not occur even when the traditional product is used.

The present invention is not limited to the above-described alternative embodiments, and various other forms of products can be obtained by anyone in light of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.

Claims

1. A skin care composition for repairing sensitive muscles is characterized by comprising a kava extract, a lonicera confusa extract, a moringa oleifera seed extract, a corydalis yanhusuo root extract, an andrographis paniculata extract, a goldthread root extract, a scutellaria baicalensis root extract and a houttuynia cordata extract.

2. The skin care composition for repairing sensitive muscles according to claim 1, which is mainly prepared from the following raw materials, by mass, 1-2% of piper wallichii extract, 0.5-1.5% of lonicera confusa extract, 0.8-1.6% of moringa oleifera seed extract, 0.8-1.6% of corydalis yanhusuo root extract, 1-2% of andrographis paniculata extract, 0.8-2% of coptis chinensis extract, 0.8-2% of scutellaria baicalensis root extract, 0.5-1.5% of houttuynia cordata extract, and the balance of cosmetic adjuvants.

3. The skin care composition for repairing sensitive muscles of claim 2, wherein said cosmetic adjunct comprises water and propylene glycol.

4. The skin care composition for repairing sensitive muscles according to claim 3, which is characterized by mainly comprising, by mass, 1-2% of Piper methysticum extract, 0.5-1.5% of Lonicera confusa extract, 0.8-1.6% of Moringa oleifera seed extract, 0.8-1.6% of corydalis yanhusuo root extract, 1-2% of Andrographis paniculata extract, 0.8-2% of Coptis chinensis extract, 0.8-2% of Scutellaria baicalensis root extract, 0.5-1.5% of houttuynia cordata extract, 8-10% of propylene glycol, and the balance of water.

5. The skin care composition for repairing sensitive muscles of any one of claims 1 to 4, further comprising kiwi extract.

6. The skin care composition for repairing sensitive muscles of claim 5, wherein the kiwi extract is an alcoholic extract of kiwi.

7. The skin care composition for repairing sensitive muscles of claim 6, further comprising Haematococcus pluvialis extract.

8. The skin care composition for repairing sensitive muscles of claim 7, wherein said Haematococcus pluvialis extract is a supercritical CO2 extract of Haematococcus pluvialis.

9. The skin care composition for repairing sensitive muscle according to claim 8, wherein the weight ratio of the kiwi fruit extract to the haematococcus pluvialis extract is 1 (0.4-0.6).

10. The skin care composition for repairing sensitive muscles of claim 9, wherein the weight ratio of kiwi extract to haematococcus pluvialis extract is 1: 0.5.