CN106726965A - Composite skin care product that antiallergic is releived and preparation method thereof - Google Patents
Composite skin care product that antiallergic is releived and preparation method thereof Download PDFInfo
- Publication number
- CN106726965A CN106726965A CN201611217415.XA CN201611217415A CN106726965A CN 106726965 A CN106726965 A CN 106726965A CN 201611217415 A CN201611217415 A CN 201611217415A CN 106726965 A CN106726965 A CN 106726965A
- Authority
- CN
- China
- Prior art keywords
- care product
- skin care
- releived
- skin
- antiallergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
Composite skin care product releived the present invention relates to a kind of antiallergic and preparation method thereof.The composite skin care product, by weight percentage, including the following raw material component：Anti-irritant component 1~5%, plant extracts 1~3%, skin barrier renovation agent 0.5~1%, NMF 0.5~1%, function additive 0.1~5%, water surplus, wherein, the anti-irritant component is α bisabolols, ginger-root extract and methylol chitosan oligosaccharide；The plant extracts is with one or more in centella, perilla seed, the windproof, flower bud of lily magnolia, the root of large-flowered skullcap for raw material is prepared.The composite skin care product, can effectively alleviate the symptoms such as heating, rubescent, itch that the skin of allergic symptom has occurred, it is to avoid skin oedema occurs because of scratching, and bleeding is festered.
Description
Technical field
The present invention relates to technical field of skin care, composite skin care product and its preparation side that more particularly to antiallergic is releived
Method.
Background technology
Sensitive from it is allergic be two different concepts.Allergic is a kind of allergy, by allergen
Into after body, promote body to produce corresponding antibodies, trigger antigen-antibody reaction, show as the clinical visitor such as erythema, papule, wheal
Sign is seen, itch is often accompanied by.Typically resulting in allergic anaphylactogen includes：Eat anaphylactogen, injectivity anaphylactogen, contact
Anaphylactogen is in the class of inhalant allergens four.And sensitive is typically the tolerance reduction to stimulating, there are a series of exceptions
Sensory reaction, sensitive skin is defined as the skin condition that a kind of height is not tolerated, is vulnerable to the excitation of various factors and produces
Shouting pain, is burnt, tight, the multiple-factor syndrome of the symptom such as itch, and skin appearance is dried often or with slight furfur, erythema.
Occupy 44% according to investigation skin allergic reaction illness rate in all kinds of allergy, think oneself as allergy skin female
Property accounts for 51.4%, and male accounts for 38.2%；49% women allergy sufferers think that allergy is relevant with menstrual period, and menopausal women skin receives extraneous ring
Border influence factor is bigger.Allergy skin is also relevant with race, and asian ancestry women is to maror, and temperature change and wind suddenly is quicker
Sense.Europe, the relevant sensitiveness crowd in the U.S., women account for 50%, and male accounts for 30%, and Chinese allergic human population account for 36%.
A large amount of New Building Materials, coating, dyestuff, medicine, food, articles for washing, furniture expelling parasite insecticide, oral cleanings
Articles for use and cosmetics etc. enter in the production and life of people, more directly result in a large amount of new anaphylactogens.
As anaphylactogen is continuously increased, the people of sensitive is more and more, the non-cosmetic allergic contact dermatitis of common skin of face
Original mainly includes：Pollen, dust, food, medicine, age, pet, season exchange, temperature change, ultraviolet irradiation；In food
Common seafood, mango, part kernel initiation allergy；Penicillin and sulfamido can all cause allergy in medicine.Age growth is
One major reason of skin allergy, young healthy skin skin barrier is intact, is not encroached on by the external world, with age skin
Fat secretion reduces thinning of skin simultaneously causes sensitive materials to be easily accessible skin.
Skin allergy can not be treated timely and effectively, because skin produces itch, calcination, shouting pain, can cause allergy people
Member is constantly grabbed around, the symptom such as cause skin oedema, bleeding occur, fester, and with inflammation, tumour, wound scar was given
Quick patient brings the bad influence of social activity, physiology, psychology, mood aspect.
It is allergic to need especially meticulous nursing.Currently for allergic, particularly sensitive skin crowd, allergy
Shape can be permanently present, it is impossible to effect a radical cure, can only require that autopath tries one's best away from or avoid contact with anaphylactogen.Cosmetics are
It is closely inseparable with people's life, there is cosmetic allergic contact dermatitis treatment and generally may require that all of cosmetics of deactivation, allow skin to have slow
The time of punching.If skin occurs in that persistently rubescent, itch, calcination, shouting pain can only just go to hospital to carry out desensitization treatment, use
The physiological saline soak of injection, even if using this physiological saline, safe, penetration is good, red, steady with subsiding a swelling, taking off
Determine the function of skin, but in general, it is also desirable to several days, red and swollen phenomenon could be eliminated.
Will develop into chronic inflammation if the symptom such as allergy recurrent exerbation or delay time is very long, occur skin it is rough and
Pigmentation.Without dermatologist's diagnosis, some medicines for containing steroids are bought in pharmacy without authorization, such as cortex renis hormone is soft
Cream etc. is used, and occupation mode and frequency do not control effectively, although it to suppressing scytitis effectively, but can for a long time make
With side effect can be produced to endanger skin health, long-term easily to expand dermal capillary obvious in the past, keratoderma becomes
Thin, barrier function declines, and easily sebum hormone is relied on, and easily occurs hormone allergy rebound phenomenon after disabling, and is formed and swashed
Plain dependence facial dermatitis.Therapy of facial hormone dependent dermatitis patient reason has one in having a strong impact on appearance, disease obstinate
Determine the feeling oneself inferior of degree, anxiety, the feared state of mind.
Subsensitivety maintenance skin care item are developed for anaphylaxis skin in cosmetic field on the market at present, also exploitation has
Anti-inflammatory, the special skin care products of skin of sedation, are primarily adapted for use in responsive type skin crowd and use, and reduce allergy probability, but simultaneously
The skin that allergic symptom has occurred can not be directed to effectively to be nursed.
The content of the invention
Based on this, it is necessary to provide the composite skin care product that a kind of antiallergic is releived, the composite skin care product can effectively delay
There is the symptoms such as the heating of the skin of allergic symptom, rubescent, itch in solution, it is to avoid skin oedema occurs because of scratching, and bleeding is festered
Deng.
The composite skin care product that a kind of antiallergic is releived, by weight percentage, including the following raw material component：
Wherein, the anti-irritant component is α-bisabolol, ginger-root extract and methylol chitosan oligosaccharide；
The plant extracts is with one or more in centella, perilla seed, the windproof, flower bud of lily magnolia, the root of large-flowered skullcap for prepared by raw material
Obtain.
It is allergic that different symptoms are presented in the different stages：The peak value of initial reaction is usual at 15 minutes or so,
Can disappear at 90 minutes or so, sometimes, the late phase response stage for occurring lasting one day for 4-6 hours after immediate reaction；Late period
Reaction includes that a large amount of inflammatory cells enter allergy region, and (eosinophil, neutrophil cell, lymphocyte and hypertrophy are thin
Born of the same parents), cause chronic anaphylaxis skin when lasting anaphylactogen causes periodic reaction thus to trigger, it more difficult to effect a radical cure.
The composite skin care product that antiallergic of the invention is releived, is that allergic symptom quickly is terminated in into initial stage, it is to avoid mistake
Quick order reaction causes tissue damage, and the injury of bigger physiology and psychology is brought to patient.The composite skin care product：(1) it is first
It is secondary to be applied to methylol chitosan oligosaccharide as anti-irritant component in skin care item, in combination with α-bisabolol and ginger-root extract,
Form action target spot complementary, compounding suppresses inflammatory factor, with multi-level, anti-irritant system the features such as Mutiple Targets reaches peace
Full Quick itch stopping, wherein, methylol oligosaccharide can prevent histamine from itching initiation with H1 histamine receptor high-affinity competitive bindings
The H1 receptor activations of sense；α-the bisabolol of natural high-purity synthesis cooperates with compounding product with ginger-root extract, can be effectively complete
The inflammation medium such as suppression cell factor 1L-6,1L-1 α, TNF α, the LTB4 and PGE-2 in face (for details, reference can be made to table 1), more
Comprehensively suppress inflammation to occur, Quick itch stopping.(2) in the market it is allergic repair class product often exist excitant compared with
By force, easily cause allergy and aggravate the phenomenon of skin ageing after disabling, the present invention is further with centella, perilla seed, windproof, pungent
One or more in the smooth, root of large-flowered skullcap is raw material prepared plant extracts, promotes skin reparation, and increasing is cooperateed with foregoing anti-irritant component
While strong antiallergic itching-relieving action, with the blood circulation for promoting subcutaneous capillary, increase the nutrition win-win of skin, adjust skin
Skin water balance etc. is acted on, and thus prevents dry skin to be dehydrated, and increases skin elasticity, so as to protect skin gloss tender, is eliminated
There is red and swollen, the symptom such as papule in the skin that allergy triggers, can not only eliminate the allergic reaction that all kinds of cosmetics cause, and can
Resist because of the skin adverse reaction that environmental pollution causes.
Table 1
Wherein in one embodiment, the anti-irritant component is that mass ratio is (0.9~2)：(0.05~0.1)：(0.1
~α-bisabolol 0.3), ginger-root extract and methylol chitosan oligosaccharide.
Wherein in one embodiment, the plant extracts is with centella, perilla seed, the windproof, flower bud of lily magnolia and the root of large-flowered skullcap as former
Material is prepared.
Wherein in one embodiment, the methylol chitosan oligosaccharide be small molecule methylol chitosan oligosaccharide, its molecular weight for≤
10000 dalton.
Wherein in one embodiment, the plant extracts with mass ratio be (10~20)：(30~4) (10~20):
(30~10)：The centella of (20~10), perilla seed, the windproof, flower bud of lily magnolia and the root of large-flowered skullcap are prepared.
Wherein in one embodiment, the preparation method of the plant extracts is：Mix centella, purple perilla in mass ratio
After sub, the windproof, flower bud of lily magnolia and the root of large-flowered skullcap, using carbon dioxide supercritical extraction, 35~40Mpa of extracting pressure, extraction temperature 50~75
DEG C, extraction time is 2~4h.
Wherein in one embodiment, the skin barrier renovation agent repaiies (INCI titles for moral skin：Hexyldecanol,
Bisabolol, Cetylhydroxyproline Palmitamide, Stearic Acid, Brassica Campestr
(Rapeseed)Sterols；Hexyl decyl alcohol, bisabolol, N- palmityl hydroxy-prolines cetyl, stearic acid, campesterol
Class).
Further combined with the skin barrier repair system using the composite highly effective, the master of simulated skin cuticula bimolecular film
Composition is wanted, the similar skin lipid bilayer of itself can be rapidly recombinated, skin is efficiently repaired, skin anti-irritant energy is improved
Power, reduces cutaneous sensibility.
Wherein in one embodiment, the NMF is that weight ratio is (5~7)：(1~3)：(0.5~0.8) it is sweet
Oil, butanediol and 24h moisturizing factors (INCI titles：Water (Aqua), Pentylene Glycol, Glycerin, Sodium
Lactate, Lactic Acid, Serine, Urea, Sorbitol, Sodium Chloride, Allantoin；Water, 1,2- penta
Glycol, glycerine, sodium lactate, lactic acid, serine, urea, sorb (sugar) alcohol, sodium chloride, allantoin).
Dry skin is to trigger one of allergic factor, and for dry skin, the gentle efficient NMF of selection can
Effectively to help the balance of moisture of skin, the percutaneous moisture loss value of skin is reduced.The present invention uses the NMF of above-mentioned compounding
System, can effectively adjust skin moisture content, soften skin, increase skin elasticity, with good long-acting moistening effect.
Wherein in one embodiment, the function additive includes preservative；The preservative be 1,2- hexylene glycols and/or
Decoyl hydroximic acid.
Wherein in one embodiment, the preservative is that weight ratio is (0.05~0.75)：The 1,2- of (0.3~0.45)
Hexylene glycol and decoyl hydroximic acid.
The composite skin care product that the present invention releives for the antiallergic that the skin of allergic symptom is used is, it is necessary to select gentle
The solution of non-stimulated preservative.And it is directed to the two of material mainly some medium chains that can declare the addition of preservative zero
First alcohol, they have good inhibiting effect to bacterium and saccharomycete, for example, 1,2- ethohexadiol, sad monoglyceride, ethylhexyl
Glycerine, but their inhibitory action to mould are undesirable, and because of the problem of heat generation, easily cause skin allergy.
The present invention carries out compounding and prepares gently in above-mentioned composite skin care product using 1,2- hexylene glycols and decoyl hydroximic acid
Non-stimulated antibacterial system.1,2- hexylene glycol is considered as one of most gentle dihydroxylic alcohols, harmless, with good antibacterial
Moistening effect, excellent aqueous solubility, when merely using 1,2- hexylene glycols, its minimum concentration is 2.5% relatively costly, by multiple
With decoyl hydroximic acid, decoyl hydroximic acid is used for animal and human body as medicine long history, and its toxicity research is obtained very
It is extensive, with high security, and to Fe2+And Fe3+There is efficient selectivity chelation, in the ring that iron ion is limited
Under border, mould growth is also limited, it is possible thereby to the usage amount of 1,2- hexylene glycols is reduced, and while not causing skin allergy, association
With enhancing antibacterial effect.
The present invention also provides the preparation method of the composite skin care product that described antiallergic is releived, and comprises the following steps：
The water and butanediol, glycerine are heated to 75~85 DEG C, 25~35min is stirred；
The skin barrier renovation agent, anti-irritant component and 24h moisturizing factors are sequentially added, 25~35min is stirred；
Temperature is cooled to for 35~45 DEG C, the function additive, plant extracts is added, you can.
Compared with prior art, the invention has the advantages that：
The composite skin care product that antiallergic of the invention is releived, using α-bisabolol, ginger-root extract and small molecule hydroxyl first
Base enclosure oligosaccharides is used as anti-irritant component, and action target spot is complementary, and compounding suppresses inflammatory factor, reach it is safely and fast antipruritic, further
It is raw material prepared plant extracts with reference to one or more in centella, perilla seed, the windproof, flower bud of lily magnolia, the root of large-flowered skullcap, can effectively delays
There is the symptoms such as the heating of the skin of allergic symptom, rubescent, itch in solution, it is to avoid skin oedema occurs because of scratching, and bleeding is festered
Deng.
Brief description of the drawings
Fig. 1 is the allergic experiment marking result of the plant extraction liquid in the embodiment of the present invention；
The alleviation pruitus effect of the composite skin care product that Fig. 2 releives for the antiallergic of the embodiment of the present invention and comparative example is surveyed
Comment result；
The alleviation rubefaction effect of the composite skin care product that Fig. 3 releives for the antiallergic of the embodiment of the present invention and comparative example is surveyed
Comment result；
The alleviation hydroderma effect of the composite skin care product that Fig. 4 releives for the antiallergic of the embodiment of the present invention and comparative example is surveyed
Comment result.
Specific embodiment
Composite skin care product releived to antiallergic of the invention below in conjunction with specific embodiment and preparation method thereof is made into one
Step detailed description.
The raw material components of the composite skin care product that the antiallergic of embodiment of the present invention 1-3 and comparative example 1-3 is releived are (with weight hundred
Divide than meter) as shown in table 2, preparation is to spray：
Table 2
The preparation steps of the composite skin care product that above-mentioned antiallergic is releived are as follows：
1st, A, B, C raw material are heated to 80 DEG C, stir 30min；
2nd, D, E, F, G, H stirring 30min is sequentially added to be well mixed；
The 3rd, water mutually reduced by 40 DEG C of temperature, I, J, K is sequentially added and is stirred and be cooled to normal temperature；
It is 4th, conventionally canned to be made spraying, you can.
Wherein, F raw materials ginger-root extract is De Minshu product efficacy components, and its main active component does not have for gingerol with red
Medicine alcohol, the two collaboration antiallergic is releived skin, and its quality control standard is as shown in table 3：
Table 3
The preparation method of K material plant extracts is as follows：
In mass ratio (10~20)：(30~4) (10~20):(30~10)：(20~10) mixing centella, perilla seed,
After the windproof, flower bud of lily magnolia and the root of large-flowered skullcap, using carbon dioxide supercritical extraction, 35~40Mpa of extracting pressure, 50~75 DEG C of extraction temperature,
Extraction time is 2~4h.
Because for anaphylaxis skin, this skin care compositions reduces the allergy probability of skin without essence.
(1) hypersensitive test marking is carried out to plant extracts.
Test method：
1st, animal selection：Cavy 20, is divided into two groups, and 10/group, back both sides depilation area is not less than 3cm*3cm；
2nd, excite：1% DNCB is smeared respectively in cavy epilating area both sides；
3rd, test, after smearing 5 minutes, start to smear test sample；
First group：Right side is not smeared (blank control group), and 1% plant extracts is smeared in left side；
Second group, dexamethasone is smeared on right side, and 3% plant extracts is smeared in left side；
4th, observe：24h、48h、72h；
5th, standards of grading：
| Dermoreaction intensity | Score value |
| Without erythema | 0 |
| Slight erythema, it is visible reluctantly | 1 |
| Moderate erythema, hence it is evident that visible | 2 |
| Severe erythema | 3 |
| Aubergine erythema, eschar is formed | 4 |
Result of the test is made as shown in figure 1, plant extraction liquid of the invention can preferably improve cavy delayed hypersensitivity reaction
It is suitable with hormone medicine dexamethasone with effect skin.
(2) effect test and appraisal are carried out to the composite skin care product that the antiallergic of embodiment and comparative example is releived.
Patch is excited to test using human body, it is study subject 20 that test object selects 18-30 Sui satisfactory volunteer
People.0.2% histamine solution is configured to using traditional Chinese medicines histamine, reagent is excited as allergy test.
Method of testing：
1) study subject cleans inboard arm totally, selects 1cm2Size is added dropwise 1-2 drops as test zone
0.2% histamine solution, carries out rush and oozes using ultrasonic wave input instrument.
2) 0.2% histamine solution 1min or so is smeared, study subject occurs in that itch, rubescent, oedema phenomenon, uses implementation
The composite skin care product releived of antiallergic of example and comparative example, by inquiry study subject pruritis, record itch disappear when
Between, observation study subject skin is rubescent, oedema vanishing state, and records the time for recovering normal skin state.
Test result：
After subject has used 0.2% HC reagent, subjects skin's reaction is recorded such as according to test judgment criteria
Shown in table 4：
Table 4
| Dermoreaction | Integration |
| 1) pruitus | |
| Without scratchiness | 0 |
| Slight gargalesthesia | 1 |
| Moderate itch | 2 |
| Severe itch, grab disturb it is antipruritic | 3 |
| 2) erythema and eschar are formed | |
| Without erythema | 0 |
| Slight erythema (visible reluctantly) | 1 |
| Obvious erythema (being dispersed in or fritter erythema) | 2 |
| Moderate~severe erythema | 3 |
| Severe erythema (aubergine) to slight eschar is formed | 4 |
| 3) oedema is formed | |
| Without oedema | 0 |
| Slight oedema (visible reluctantly) | 1 |
| Intermediate edema (cutaneous protuberance is clear-cut) | 2 |
| (cutaneous protuberance is about 1mm or more than 1mm to severe edema | 3 |
After having used 0.2% histamine solution to smear, study subject dermoreaction, pruritis integration is 2- to subject
3, erythema generally integration is at 2-3 points；Hydroderma is integrated in 2-3.
The composite skin care product that subject is releived using the antiallergic of embodiment and comparative example, carries out dermoreaction observation experiment
Result is tested average value of giving a mark with subject and recorded, and pruitus contrast is as shown in Figure 2, rubefaction contrasts as shown in Figure 3, skin
Skin oedema is as shown in Figure 4.
Experiment conclusion, all subjects in 10 minutes are effective for the composite skin care product releived using antiallergic of the invention
Antipruritic, in 1h, skin is rubescent and edematous state is relieved, and rubescent, the skin condition of oedema is eliminated to skin in 2h, recovers
To normal skin state.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. the composite skin care product that a kind of antiallergic is releived, it is characterised in that by weight percentage, including the following raw material component：
Wherein, the anti-irritant component is α-bisabolol, ginger-root extract and methylol chitosan oligosaccharide；
The plant extracts is with one or more in centella, perilla seed, the windproof, flower bud of lily magnolia, the root of large-flowered skullcap for raw material is prepared.
2. the composite skin care product that antiallergic according to claim 1 is releived, it is characterised in that the anti-irritant component is matter
Amount is than being (0.9~2)：(0.05~0.1)：α-the bisabolol of (0.1~0.3), ginger-root extract and methylol chitosan oligosaccharide.
3. the composite skin care product that antiallergic according to claim 1 is releived, it is characterised in that the plant extracts is with product
Snow grass, perilla seed, the windproof, flower bud of lily magnolia and the root of large-flowered skullcap are prepared for raw material.
4. the composite skin care product that antiallergic according to claim 1 is releived, it is characterised in that the plant extracts is with matter
Amount is than being (10~20)：(30~4) (10~20):(30~10)：The centella of (20~10), perilla seed, the windproof, flower bud of lily magnolia and Huang
A kind of reed mentioned in ancient books is prepared for raw material.
5. the composite skin care product that antiallergic according to claim 4 is releived, it is characterised in that the system of the plant extracts
Preparation Method is：In mass ratio after mixing centella, perilla seed, the windproof, flower bud of lily magnolia and the root of large-flowered skullcap, using carbon dioxide supercritical extraction,
35~40Mpa of extracting pressure, 50~75 DEG C of extraction temperature, extraction time is 2~4h.
6. the composite skin care product that the antiallergic according to claim any one of 1-5 is releived, it is characterised in that the skin screen
Barrier renovation agent is repaiied for moral skin.
7. the composite skin care product that the antiallergic according to claim any one of 1-5 is releived, it is characterised in that the NMF
For weight ratio is (5~7)：(1~3)：The glycerine of (0.5~0.8), butanediol and 24h moisturizing factors.
8. the composite skin care product that the antiallergic according to claim any one of 1-5 is releived, it is characterised in that the function is helped
Agent includes preservative；The preservative is 1,2- hexylene glycols and/or decoyl hydroximic acid.
9. the composite skin care product that antiallergic according to claim 8 is releived, it is characterised in that the preservative is weight ratio
(0.05~0.75)：The 1,2- hexylene glycols and decoyl hydroximic acid of (0.3~0.45).
10. the preparation method of the composite skin care product that the antiallergic described in any one of claim 7-9 is releived, it is characterised in that bag
Include following steps：
The water and butanediol, glycerine are heated to 75~85 DEG C, 25~35min is stirred；
The skin barrier renovation agent, anti-irritant component and 24h moisturizing factors are sequentially added, 25~35min is stirred；
Temperature is cooled to for 35~45 DEG C, the function additive, plant extracts is sequentially added, you can.
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