CN104644510A - Anti-allergic facial mask fluid for promoting skin regeneration - Google Patents
Anti-allergic facial mask fluid for promoting skin regeneration Download PDFInfo
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- CN104644510A CN104644510A CN201510095165.6A CN201510095165A CN104644510A CN 104644510 A CN104644510 A CN 104644510A CN 201510095165 A CN201510095165 A CN 201510095165A CN 104644510 A CN104644510 A CN 104644510A
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- skin
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- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- SGEWCQFRYRRZDC-VPRICQMDSA-N vitexin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O SGEWCQFRYRRZDC-VPRICQMDSA-N 0.000 description 1
- PZKISQRTNNHUGF-UHFFFAOYSA-N vitexine Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O PZKISQRTNNHUGF-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses anti-allergic facial mask fluid for promoting skin regeneration. According to the anti-allergic facial mask fluid, a variety of pure natural plant extracting solutions are in combined use to achieve a certain synergistic effect, immunoregulation and inflammation prevention can be really achieved endogenously, the self-repairing ability of the skin can also be activated, and after the anti-allergic facial mask fluid is used, the skin is comfortable, no irritation can be caused, and erythema can be improved. Relative to the total mass of the facial mask fluid, the anti-allergic facial mask fluid comprises the following components in percentage by mass: 0.1-0.2% of hyaluronic acid, 0.5-1% of tranexamic acid, 0.05-0.1% of methyl hesperidin, 0.01-0.03% of carboxymethyl dextran, 2-3% of a wheat protein hydrolysate, 0.5-0.8% of a common lophatherum herb extracting solution, 1-1.5% of a baikal skullcap root extracting solution, 2.3-3% of a danshen root extracting solution, 0.3-0.5% of a fresh ginger extracting solution, 0.5% of an aloe extracting solution, 2-2.5% of a wild chrysanthemum flower extracting solution, 0.2-0.8% of a largehead atractylodes rhizome extracting solution and 0.2-0.3% of 1,2-hexanediol.
Description
Technical field
The present invention relates to a kind of facial mask liquid, particularly relate to that a kind of safety has no side effect, can sensitivity be repaired, promote skin regeneration facial mask liquid.
Background technology
Owing to selecting improper and frequent life-time service cosmetics and cleaning supplies and weakening of the skin tolerance caused, skin sensitivity can be caused.Consequent symptom comprises, visible condition susceptible: erythema and casting off a skin; More the supraneural discomfort of subjective sensation, such as twinge, scorching hot, pruritus, tight etc.
Sensitive-skinned feature; 1, epiderm skin is thin, and blood capillary is obvious; 2, skin lacks gloss, cheek easily congested redness; 3, skin is made easily to present unsure state because of seasonal variations; Situation, there will be itch, rise erythra; 4, cold wind, food, water quality, ultraviolet, synthetic fibers, fragrance is subject to; Or the impact of material.The physiological period of healthy skin is 28 days, forms the compact texture of marshalling, provide skin to protect fully and moisture-keeping functions from basal layer to horny layer.Skin has normal physiological period, and the horny layer horn cell of the skin the superiors can arrange very neat, and lines is very careful, oil-water balance.The skin metabolism period staggering of responsive skin; epidermal structure arrangement is mixed and disorderly; Skin Cell is not when also immaturity, nature moisturizing factor and intercellular lipid also manufacture complete; horny layer has just peeled off, and keratodermatitis cell arrangement is irregular, and can up roll up crowded; the moisture content of skin inside easily runs off; do not have the protection of sebum film, excitor substance or allergin easily invade, and cause the inner inflammation of skin.
Make the reason applied some make up because improper, the people of current sensitivity subhealth state skin quality gets more and more.The product of most of antiallergic sense on the market, be only calm antiinflammatory, this is helpful to immediate allergic skin, but use is little in fact to the conditioning of sensitive skin.Also there are some high-tech biological polypeptides now, as EGF epidermal growth factor, horny layer can be repaired to a certain extent, but it are expensive, and there is no the effect of immunomodulating anti-inflammatory.
The present invention aims to provide one and makes full use of pure natural plant extract, especially the facial mask liquid of Chinese medicine ingredients, and each component is collaborative can be played calm, and anti-inflammatory, neu-roimmunomodulation, promotes skin regeneration, the rational facial mask liquid of cost.
Summary of the invention
Based on the technical problem that background technology exists, the present invention is directed to current anti-sensitive product poor effect, can not from endogenous immunity moderation, and the problem of high cost, provide a kind of promotion skin regeneration newly, antiallergic sense, the facial mask liquid of anti-inflammatory.
Trenaxmine is a kind of synthetic aminoacid, it is a kind of protease inhibitor, energy protease inhibition is to the catalytic action of peptide bond hydrolysis, thus prevent the activity as enzymes such as inflammatory protease, and then inhibit the confusion of epidermis cell function at black speck position, and check melanin enhancer group, then the approach that the melanin thoroughly breaking off being formed because of ultraviolet radiation occurs.Namely allow black speck no longer thicken, expand and increase, thus can effectively prevent and improve the pigmentation of skin.
Hesperidin methyl is the mixture of water solublity multiple flavanone type hesperidin methyl.The effect causing the tryrosinase of skin darkening can be suppressed, can be used for dermatosis such as treatment black speck, freckle etc.Have and maintain the normal permeability of blood vessel, improve capillary resistance, strengthen elasticity and the toughness of blood capillary, prevent and treat capillary hemorrhage, gingival hemorrhage etc.
Sensor Chip CM 5 is a kind of cosmetics bio feedstocks with the effect of startup skin self epidemic preventing mechanism; it is by active cell immune system thus reach and improve the immunocompetence of skin; the synthesis of protection collagen protein; improve the elasticity of skin; repair damaged skin; diminish inflammation and antiallergic, simultaneously also there is photoprotection, be specially suitable for the reparation of shining rear skin.
Herba Lophatheri extracting solution, Herba Lophatheri another name bamboo Radix Ophiopogonis, long Folium Bambusae, Gallus jabouillei rice etc.For the stem and leaf of this tannin plant of standing grain Herba Lophatheri.Herba Lophatheri is containing triterpenoid, plant sterol, chromocor compound, alkaloid, phenols component, polysaccharide etc.Triterpenoid is the main component of Herba Lophatheri, has freidelin, arundoin, Cylindrin, alnulin, tricin, Tricin-7-O-β-D-glucoside etc.; Plant sterol has cupreol, stigmasterol, campesterol etc.; Chromocor compound is vitexin; Alkaloid has thymus pyrimidine, adenine etc.; Phenols component has syringaldehyde, trans to hydroxyl cinnamic aldehyde, vanillin etc.Herba Lophatheri extract has good inhibitory action to tyrosinase, and in conjunction with the suppression of Herba Lophatheri extract to keratinization enzyme, keratinization enzymatic makes that horny layer is aging, color and luster is deepened, and therefore extract can be used for desalinating the colour of skin, eliminates mottle; Herba Lophatheri extract has facilitation to rats hair growth, can correspondingly for product for improving hair-growing; The zoopery of Herba Lophatheri extract shows, its tool suppresses function that is irritated and that scratch where it itches, can be used as the anti-allergic agent of cosmetics.
Radix Scutellariae extracting solution is to the activation of luciferase and the promotion to interferon secretion, and this illustrates suppression dermatitis, and increasing skin resistance has effect, has anti-inflammatory.With the ability of histamine during Radix Scutellariae extracting solution has, so allergy can be prevented and treated.
Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract, main chemical compositions: tanshinone ⅡA, salvianolic acid B, cryptotanshinone: mainly contain fat-soluble non-quinochrome compounds, as tanshinone ⅡA, Tanshinone II B, cryptotanshinone and isomer thereof.Water-soluble phenolic acrylic component is as protocatechualdehyde, danshensu.Wherein, cryptotanshinone and danshensu are antibacterial effective ingredient, there is blood circulation promoting and blood stasis dispelling, improve blood circulation effect, also have good curative effect to pyogenic infections from tumour or sore, acne can be eliminated in cosmetics, the anti-pox of anti-pox, containing collagen synthesis inhibitors, can cure pockmark pox pimple, eliminate scar, improve texture.
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens (Zingiber officinale Roscoe), and another name has race, hundred peppery clouds, hook dress refers to, because of pungent, the hot and cold boy in ground, fresh ginger, processed with honey Rhizoma Zingiberis Recens.The rhizome (Rhizoma Zingiberis) of Rhizoma Zingiberis Recens, cork (Cortex Zingiberis), leaf (Folium Zingiberis) all can be used as medicine.Rhizoma Zingiberis Recens have in Chinese medicine and pharmacy disperse, preventing or arresting vomiting, the effect such as cough-relieving.Ginger extract all has obvious inhibitory action to staphylococcus aureus, Staphylococcus albus, Bacillus typhi, bacterium sonnei, bacillus pyocyaneus, its effect is dependence with concentration. and especially the strongest with the inhibitory action of staphylococcus aureus and Staphylococcus albus, also there is the effect significantly suppressing dermatophytes and kill connections trichomonas vaginitis, various carbuncle sore tumefacting virus can be treated.Can chafe, blood circulation promoting etc. effect, control dandruff while can promote hair growth.
Hydrolyzed wheat protein, CAS:70084-87-6, Semen Tritici aestivi oligopeptide is for raw material with the protein extracted in Semen Tritici aestivi, adopt multiple enzyme preparation, by the micromolecule polypeptide material that directed enzyme action and specific little peptide isolation technics obtain, while keeping former nutrient protein characteristic, also there is good water solublity, emulsibility, compatibility, easy absorption, the features such as biological activity is strong.Semen Tritici aestivi oligopeptide contains each seed amino acid of needed by human body, particularly containing abundant glutamine.And glutamine is extremely important antioxidant in compound body---the precursor substance of reduced glutathion.Therefore, wheat protein oligopeptide has excellent oxidation resistance.
Aloe is the one of Cycas revoluta, Aloe various in style, wherein fresh Aloe extraction solution is most good merchantable brand, it is a kind of wholefood, medicine, cosmetics additive of mystery, containing abundant skin-nourishing element, as various active compositions such as vitamin, aminoacid, glucoside, choline saccharide, compound mucopolysaccharide, protein, mineral, enzyme, aloin, aloe-emodins.
Flos Chrysanthemi Indici extracting solution is the head titbit of feverfew Herba Dendranthematis indici.Containing acacetin-7-rhamnose Fructus Vitis viniferae glycoside, Flos Chrysanthemi Indici lactone, Chrysanthemin, bitter principle, chrysol, chrysanthone, northern Camphora, another containing retinoid material and vitamin B1, there is balanced fat secretion, suppress anti-pox, prevent acne, the effect of bactericidal antiphlogistic.
The Rhizoma Atractylodis Macrocephalae, Classification system Atractylodes macrocephala.Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., belong to catananche.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Mainly be distributed in the mountain area wetlands such as Sichuan, Yunnan, Guizhou.Its Main Ingredients and Appearance containing volatile oil, atractylol, atractylone and vitamin A, the main diuresis of its pharmacology, reduces blood glucose, anticoagulant, strong human body and antibacterial action.
In general, Rhizoma Zingiberis Recens is considered to be not suitable for sensitive-skinned, because its zest is larger, but the present inventor finds, in this special prescription, suitably add Rhizoma Zingiberis Recens make it promote on the contrary skin regeneration capacity is strengthened greatly, skin is also had no stimulation.
The present inventor, on a large amount of practical basis, by updating formula, developing described multicomponent Synergistic, having immunomodulating, repairs responsive, promotes the outstanding facial mask liquid of the effects such as skin regeneration.
Technical scheme of the present invention is as follows:
Promote a facial mask liquid for skin regeneration antiallergic, relative to the gross mass of facial mask liquid, containing following component:
Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%, wheat protein hydrolyzed solution 2%-3%; Herba Lophatheri extracting solution 0.5%-0.8%; , Radix Scutellariae extracting solution 1%-1.5%, red sage root extracting solution 2.3%-3%, ginger extract 0.3%-0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%-2.5%; Rhizoma Atractylodis Macrocephalae extracting solution 0.2%-0.8%; 1,2-hexanediol 0.2%-0.3%.
Preferably, in described facial mask liquid, relative to the gross mass of facial mask liquid, also containing following component:
Transparent HANSHENGJIAO 0.05%-0.2%; Hyaluronic acid 0.1%-0.2%, Preservative qs.
Described antiseptic is preferably: natural antiseptic agent CMG, chemical composition: fatty acid isomer, SUNSOFT 700P-2.
Preferably, in described facial mask liquid, relative to the gross mass of facial mask liquid, composed of the following components:
Hyaluronic acid 0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.8%; , Radix Scutellariae extracting solution 1.5%, red sage root extracting solution 2.3%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.8%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.5%; Transparent HANSHENGJIAO 0.15%.
Promote a preparation method for the facial mask liquid facial mask liquid of skin regeneration antiallergic, comprise the following steps:
(1) during heating water to 95 DEG C, vacuum suction, in emulsifying pot, adds transparent HANSHENGJIAO homogenizing process 5 minutes under processing condition;
(2) when temperature is reduced to below 40 DEG C, add in emulsifying pot and add hyaluronic acid 0.1%-0.2% with the gross mass of relative facial mask liquid, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%, wheat protein hydrolyzed solution 2%-3%; Herba Lophatheri extracting solution 0.5%-0.8%; , Radix Scutellariae extracting solution 1%-1.5%, red sage root extracting solution 2.3%-3%, ginger extract 0.3%-0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%-2.5%; Rhizoma Atractylodis Macrocephalae extracting solution 0.2%-0.8%; 1,2-hexanediol 0.2%-0.3%, Preservative qs;
(3) be down to room temperature, complete the preparation to facial mask liquid.
Preferably, in the preparation method of the facial mask liquid of described promotion skin regeneration antiallergic, described hyaluronic acid 0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.8%; , Radix Scutellariae extracting solution 1.5%, red sage root extracting solution 2.3%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.8%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.5%; Transparent HANSHENGJIAO 0.15%.
Usefulness of the present invention is:
1, facial mask liquid of the present invention can be real from endogenous immunity moderation, and anti-inflammatory, and the repair ability activating skin self, use rear skin comfort, without any stimulation, improves erythema.
2, facial mask liquid of the present invention significantly can impel the generation of proopiomelanocortin derived peptide, and this illustrates that it has obviously calm effect, reduces cutaneous sensibility.
3, use facial mask liquid of the present invention that TEWL can be allowed to reduce 20%-31%, skin can be allowed to obtain good reparation.
4, facial mask liquid of the present invention has very excellent skin-tolerant, acceptance, nontoxic not sensitization.
5, facial mask liquid skinfeel of the present invention is good, uses comfortable, uses rear skin layer thickness obviously to increase, and has the Keratinocytic quantity of core also significantly to increase, thus maintains cuticle state, repairs skin barrier function.
Accompanying drawing explanation
Fig. 1 is after the facial mask liquid human body keratinocyte of embodiment of the present invention 1-4, and IL-1 α growing amount % is relative to the relation of matched group.
Fig. 2 is after the facial mask liquid human body keratinocyte of embodiment of the present invention 1-4, and TNF-α growing amount % is relative to the relation of matched group.
Fig. 3 is that after the facial mask liquid human body keratinocyte of embodiment of the present invention 1-4, IL-10 growing amount % is relative to the relation of matched group.
Fig. 4 carries out 28 days treatment after dates, skin histology's picture by the facial mask liquid of the embodiment of the present invention.
Detailed description of the invention
The extracting solution that all embodiments of the present invention are used can purchased from any company, and many producers are in stock.
Embodiment 1:
Promote a preparation method for the facial mask liquid facial mask liquid of skin regeneration antiallergic, comprise the following steps:
During heating water to 95 DEG C, vacuum suction is in emulsifying pot, adds transparent HANSHENGJIAO homogenizing process 5 minutes under processing condition;
When temperature is reduced to below 40 DEG C, adds in emulsifying pot and add hyaluronic acid 0.15% with the gross mass of relative facial mask liquid, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.8%; , Radix Scutellariae extracting solution 1.5%, red sage root extracting solution 2.3%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.8%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.5%;
Be down to room temperature, complete the preparation to facial mask liquid.
In described step one, relative to the gross mass of facial mask liquid, the additional proportion of transparent HANSHENGJIAO is 0.15%.
Embodiment 2:
Promote a preparation method for the facial mask liquid facial mask liquid of skin regeneration antiallergic, comprise the following steps:
During heating water to 95 DEG C, vacuum suction is in emulsifying pot, adds transparent HANSHENGJIAO homogenizing process 5 minutes under processing condition;
When temperature is reduced to below 40 DEG C, adds in emulsifying pot and add hyaluronic acid 0.1% with the gross mass of relative facial mask liquid, Trenaxmine 1%, hesperidin methyl 0.05%, Sensor Chip CM 5 0.01%, wheat protein hydrolyzed solution 3%; Herba Lophatheri extracting solution 0.5%; , Radix Scutellariae extracting solution 1%, red sage root extracting solution 3%, ginger extract 0.3%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2.5%; Rhizoma Atractylodis Macrocephalae extracting solution 0.2%; 1,2-hexanediol 0.2%, water-soluble azone 0.5%, natural antiseptic agent CMG0.2%;
Be down to room temperature, complete the preparation to facial mask liquid.
In described step one, relative to the gross mass of facial mask liquid, the additional proportion of transparent HANSHENGJIAO is 0.2%.
Embodiment 3:
Promote a preparation method for the facial mask liquid facial mask liquid of skin regeneration antiallergic, comprise the following steps:
During heating water to 95 DEG C, vacuum suction is in emulsifying pot, adds transparent HANSHENGJIAO homogenizing process 5 minutes under processing condition;
When temperature is reduced to below 40 DEG C, adds in emulsifying pot and add hyaluronic acid 0.2% with the gross mass of relative facial mask liquid, Trenaxmine 0.8%, hesperidin methyl 0.06%, Sensor Chip CM 5 0.02%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.7%; , Radix Scutellariae extracting solution 1.3%, red sage root extracting solution 2.6%, ginger extract 0.4%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2.2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.5%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.4%;
Be down to room temperature, complete the preparation to facial mask liquid.
In described step one, relative to the gross mass of facial mask liquid, the additional proportion of transparent HANSHENGJIAO is 0.08%.
Embodiment 4:
Promote a preparation method for the facial mask liquid facial mask liquid of skin regeneration antiallergic, comprise the following steps:
During heating water to 95 DEG C, vacuum suction is in emulsifying pot, adds transparent HANSHENGJIAO homogenizing process 5 minutes under processing condition;
When temperature is reduced to below 40 DEG C, adds in emulsifying pot and add hyaluronic acid 0.1% with the gross mass of relative facial mask liquid, Trenaxmine 0.6%, hesperidin methyl 0.09%, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 3%; Herba Lophatheri extracting solution 0.6%; , Radix Scutellariae extracting solution 1.2%, red sage root extracting solution 2.9%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2.4%; Rhizoma Atractylodis Macrocephalae extracting solution 0.7%; 1,2-hexanediol 0.2%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.3%;
Be down to room temperature, complete the preparation to facial mask liquid.
In described step one, relative to the gross mass of facial mask liquid, the additional proportion of transparent HANSHENGJIAO is 0.05%.
Embodiment 5:
The test of the present embodiment is all carry out at Rizhao City, Shandong Province Ou Zi cosmetics company limited laboratory.
(1) ion vitro immunization regulates active testing
IL-1 α and TNF-α is proinflammatory factor, and IL-10 is immunosuppressive factor, increases with advancing age.
Under light illuminate condition, in not containing the DMEM of serum, process keratinocyte 72 hours by the facial mask liquid of the present embodiment, matched group is blank group.
Result shows, and IL-1 α, TNF-α under light illumination, the growing amount of IL-10 all sharply rises, but with after the process of the present embodiment facial mask liquid, the minimizing more remarkable in matched group of its growing amount, result as illustrated in the accompanying drawings from 1 to 3.This shows, under light illumination, facial mask liquid of the present invention has significant regulating and controlling effect to the generation of this type of factor in Human Keratinocytes's culture, has antiphlogistic effects.Especially the facial mask liquid of embodiment 1, compares matched group down ratio maximum.Thus can judge, facial mask liquid of the present invention can promote skin homeostasis by immunoregulatory method.
CGRP is the strongest known at present expansion angiogenic substance, has lower blood pressure lowering, an effect that Peripheral resistance reduction, renal artery diastole, renal blood flow obviously increase.CGRP also has powerful diastole effect to coronary artery, also effective to atherosis coronary artery, its diastole effect is about stronger than nitroglycerin, sodium nitroprusside 240 times, this diastole effect does not rely on the existence of blood vessel endothelium, also be not subject to the impact of A, B and 5-hydroxytryptamine receptor blocker, illustrate that CGRP is incorporated into specific CGRP receptor.CGRP can also make arteria coronaria perfusion pressure reduce, coronary flow obviously increases, heart rate, myocardial contraction strengthens, CGRP has obvious positive inotropic and positive chronotropic action, this effect comparatively norepinephrine is strong, but can be cancelled by B receptor blocking agent, and its mechanism may be relevant with cAMP level in rising myocardial cell.The antiarrhythmic effect of CGRP is about stronger than calcium-channel antagonists 220 times, and its mechanism of action may be the interior stream regulating myocardial cell.CGRP all has obvious diastole effect to all blood vessels, and it acts on comparatively, and the material such as acetylcholine is strong.
Under UV stimulates, act on keratinocyte culture, the facial mask liquid of embodiment 1-4 also observe can reduce CGRP formed reach 40%, 25%, 20%, 26%, this proves that described facial mask liquid has positive effect for a very important Anti-inflammatory Mechanism, that is exactly the sensory nerve signal that it can reduce sensitivity skin, can regulate endogenous immunocompetence.
In addition, also find that facial mask liquid of the present invention significantly can impel the generation of proopiomelanocortin derived peptide, this illustrates that it has obviously calm effect, reduces cutaneous sensibility, maintains skin tissue's integrity and alleviates skin ageing phenomenon.
(2) the actual test of volunteer
100 sensitivity skin testers (determining through zest test), the range of age: 40-55 year, be divided into 5 groups, often organize 20 testers, there was no significant difference between each group.Use the silk mask that the facial mask liquid of an embodiment 1-4 is made every day, each application 20 minutes, use 28 days.Matched group uses placebo facial film, only has replenishing water and preserving moisture effect.
The reparation of skin and maintenance can produce qualitative change to sensitive skin essence usually.TEWL (Tewameter
tM, Courage-Khazaka), percutaneous moisture finds through (TEWL) assessment, and after 28 days, TEWL reduces 20%-31%.This proves that skin obtains good reparation.
Other results are as shown in table 1:
Table 1
As can be seen here, facial mask liquid of the present invention significantly can improve skin feel, reduces erythema, strengthens skin to the adaptive faculty stimulated, improves xerosis cutis.In addition, also find, facial mask liquid of the present invention has certain whitening effect.
In addition, carry out skin histology's inspection, as shown in Figure 4,28 days treatment after dates, skin layer thickness obviously increases, and has the Keratinocytic quantity of core also significantly to increase, thus maintains cuticle state, repairs skin barrier function.
Visible, facial mask liquid of the present invention has extraordinary improvement result to sensitive skin.
(3) toxicology test
Mice is selected to carry out toxicology test, result:
Under 25% aqueous solution:
Acute oral toxicity: nontoxic
Eye irritation: tolerate very much
Sensitization test (STT): without sensitization
Single epidermis patch test: fabulous toleration
To 3T3-NRU 3T3 fibroblast red untake Phototoxicity experiment (assessment phototoxicity): without phototoxicity.
Result shows, and facial mask liquid of the present invention has very excellent skin-tolerant, acceptance, nontoxic not sensitization.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (4)
1. promote a facial mask liquid for skin regeneration antiallergic, it is characterized in that: relative to the gross mass of facial mask liquid, containing following component:
Hyaluronic acid 0.1%-0.2%, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%, wheat protein hydrolyzed solution 2%-3%; Herba Lophatheri extracting solution 0.5%-0.8%; , Radix Scutellariae extracting solution 1%-1.5%, red sage root extracting solution 2.3%-3%, ginger extract 0.3%-0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%-2.5%; Rhizoma Atractylodis Macrocephalae extracting solution 0.2%-0.8%; 1,2-hexanediol 0.2%-0.3%.
2. the facial mask liquid of promotion skin regeneration antiallergic according to claim 1, is characterized in that: relative to the gross mass of facial mask liquid, containing following component:
Hyaluronic acid 0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.8%; , Radix Scutellariae extracting solution 1.5%, red sage root extracting solution 2.3%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.8%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CM60.5%; Transparent HANSHENGJIAO 0.15%.
3. promote a preparation method for the facial mask liquid of skin regeneration antiallergic, comprise the following steps:
(1) during heating water to 95 DEG C, vacuum suction, in emulsifying pot, adds the process of transparent HANSHENGJIAO homogenizing under processing condition;
(2) when temperature is reduced to below 40 DEG C, add in emulsifying pot and add hyaluronic acid 0.1%-0.2% with the gross mass of relative facial mask liquid, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%, wheat protein hydrolyzed solution 2%-3%; Herba Lophatheri extracting solution 0.5%-0.8%; , Radix Scutellariae extracting solution 1%-1.5%, red sage root extracting solution 2.3%-3%, ginger extract 0.3%-0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%-2.5%; Rhizoma Atractylodis Macrocephalae extracting solution 0.2%-0.8%; 1,2-hexanediol 0.2%-0.3%, Preservative qs;
(3) be down to room temperature, complete the preparation to facial mask liquid.
4. the preparation method of the facial mask liquid of promotion skin regeneration antiallergic according to claim 3, it is characterized in that: the gross mass of facial mask liquid adds hyaluronic acid 0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1% relatively, Sensor Chip CM 5 0.03%, wheat protein hydrolyzed solution 2%; Herba Lophatheri extracting solution 0.8%; , Radix Scutellariae extracting solution 1.5%, red sage root extracting solution 2.3%, ginger extract 0.5%, Aloe extraction solution 0.5%; Flos Chrysanthemi Indici extracting solution 2%; Rhizoma Atractylodis Macrocephalae extracting solution 0.8%; 1,2-hexanediol 0.3%, water-soluble azone 0.5%, natural antiseptic agent CMG 0.5%; Transparent HANSHENGJIAO 0.15%.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236619A (en) * | 2016-07-27 | 2016-12-21 | 南京正宽医药科技有限公司 | The extracting method of a kind of Aloe and Aloe acne eliminating cream |
| CN106726965A (en) * | 2016-12-26 | 2017-05-31 | 湖南御家化妆品制造有限公司 | Composite skin care product that antiallergic is releived and preparation method thereof |
| CN108703928A (en) * | 2018-08-06 | 2018-10-26 | 李媛媛 | A kind of whitening spot-removing moisturizing gel and preparation method thereof |
| CN109568246A (en) * | 2018-12-24 | 2019-04-05 | 广州欧盛化妆品有限公司 | A kind of crease-resistant moisturiser and preparation method thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN110279642A (en) * | 2019-08-09 | 2019-09-27 | 广州环亚化妆品科技有限公司 | Skin care composition and preparation method and application thereof |
| CN110731912A (en) * | 2019-11-20 | 2020-01-31 | 广州瑞誉化工科技有限公司 | whitening and anti-aging essence |
| CN115350196A (en) * | 2022-10-17 | 2022-11-18 | 山东科金生物发展有限公司 | Biological preparation for reducing skin aging and improving skin injury repair |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100717884B1 (en) * | 2007-01-31 | 2007-05-16 | 남성준 | Antibiotic mask |
| CN102429839A (en) * | 2010-09-29 | 2012-05-02 | 李振阳 | Method for preparing facial mask soaking liquid |
-
2015
- 2015-03-04 CN CN201510095165.6A patent/CN104644510B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100717884B1 (en) * | 2007-01-31 | 2007-05-16 | 남성준 | Antibiotic mask |
| CN102429839A (en) * | 2010-09-29 | 2012-05-02 | 李振阳 | Method for preparing facial mask soaking liquid |
Non-Patent Citations (1)
| Title |
|---|
| 千太阳: "《韩医皮肤专家金昭亨教你打造韩式肌肤》", 31 January 2010, 中国轻工业出版社 * |
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| CN106726965A (en) * | 2016-12-26 | 2017-05-31 | 湖南御家化妆品制造有限公司 | Composite skin care product that antiallergic is releived and preparation method thereof |
| CN106726965B (en) * | 2016-12-26 | 2020-06-23 | 湖南御家化妆品制造有限公司 | Anti-allergy and soothing skin care product composition and preparation method thereof |
| CN108703928A (en) * | 2018-08-06 | 2018-10-26 | 李媛媛 | A kind of whitening spot-removing moisturizing gel and preparation method thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN109568246A (en) * | 2018-12-24 | 2019-04-05 | 广州欧盛化妆品有限公司 | A kind of crease-resistant moisturiser and preparation method thereof |
| CN110279642A (en) * | 2019-08-09 | 2019-09-27 | 广州环亚化妆品科技有限公司 | Skin care composition and preparation method and application thereof |
| CN110731912A (en) * | 2019-11-20 | 2020-01-31 | 广州瑞誉化工科技有限公司 | whitening and anti-aging essence |
| CN115350196A (en) * | 2022-10-17 | 2022-11-18 | 山东科金生物发展有限公司 | Biological preparation for reducing skin aging and improving skin injury repair |
| CN115350196B (en) * | 2022-10-17 | 2023-02-03 | 山东科金生物发展有限公司 | Biological preparation for reducing skin aging and improving skin injury repair |
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