CN104644510B - A kind of facial mask liquid for promoting skin regeneration antiallergic - Google Patents
A kind of facial mask liquid for promoting skin regeneration antiallergic Download PDFInfo
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- CN104644510B CN104644510B CN201510095165.6A CN201510095165A CN104644510B CN 104644510 B CN104644510 B CN 104644510B CN 201510095165 A CN201510095165 A CN 201510095165A CN 104644510 B CN104644510 B CN 104644510B
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- extract solution
- facial mask
- mask liquid
- extract
- skin
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of facial mask liquid for promoting skin regeneration antiallergic, it is used in combination a variety of pure plant extract solutions, reaches certain synergy, rear skin comfort can be used really from the immune anti-inflammatory of endogenous regulation, and activate the repair ability of skin itself, without any stimulation, improve erythema.Relative to the gross mass of facial mask liquid, it contains following components：Hyaluronic acid 0.1% 0.2%, Trenaxmine 0.5% 1%, hesperidin methyl 0.05% 0.1%, Sensor Chip CM 5 0.01% 0.03%, wheat gluten hydrolyzate 2% 3%；Henon bamboo leaf extract 0.5% 0.8%；Radix scutellariae extract solution 1% 1.5%, red sage root extract solution 2.3% 3%, ginger extract 0.3% 0.5%, extract solution from aloe 0.5%；Chrysanthemum indicum extract solution 2% 2.5%；Bighead atractylodes rhizome extract solution 0.2% 0.8%；1,2 hexylene glycol 0.2% 0.3%.
Description
Technical field
The present invention relates to a kind of facial mask liquid, more particularly to it is a kind of it is having no side effect safely, sensitivity can be repaired, promote skin again
Raw facial mask liquid.
Background technology
Skin tolerance subtracts caused by selecting improper and frequent long-term use of cosmetics and cleaning supplies
It is weak, skin sensitivity can be caused.Resulting symptom includes, it is seen that condition susceptible：Erythema and husking；It is more subjective sense
Feel supraneural discomfort, such as shouting pain, scorching hot, itch, tight etc..
The feature of sensitive skin；1st, epiderm skin is thin, and capilary is obvious；2nd, it is easily congested red and swollen to lack gloss, cheek for skin；
3rd, cause skin that unsure state is easily presented because of seasonal variations；Situation, it may appear that itch, play fash；4th, easily by cold wind,
Food, water quality, ultraviolet, synthetic fibers, fragrance；Or the influence of material.The physiological period of healthy skin is 28 days, from substrate
Layer forms the compact texture of marshalling to cuticula, there is provided skin sufficiently protects and moisture-keeping functions.Skin possesses normally
Physiological period, the cuticula horn cell of the skin the superiors can arrange very neatly, and lines is extremely careful, oil-water balance.Sensitive flesh
The skin metabolism period staggering of skin, epidermal structure arrangement is mixed and disorderly, Skin Cell also prematurity, NMF and iuntercellular fat
When matter is also manufactured without complete, cuticula just peels off, and keratoderma cell arrangement is irregular, and can up roll up crowded, skin
Internal moisture content is easily lost in, and without the protection of sebum film, excitor substance or allergin easily invade, and causes to send out inside skin
It is scorching.
Because improper the reason for using cosmetics, the people of the skin quality of sensitiveness inferior health at present is more and more.It is most on the market
The product of number antiallergic senses, anti-inflammatory of only calming, this is helpful to immediate allergic skin, but the conditioning to sensitive its
At practicality less.Also there are some high-tech biological polypeptides now, such as EGF EGFs, can repair to a certain extent
Cuticula, but its is expensive, and adjusted without immune
The present invention is intended to provide one kind makes full use of the facial mask liquid of pure natural plant extract, especially traditional Chinese medicine ingredients, respectively
Component collaboration can play calm, anti-inflammatory, neu- roimmunomodulation, promote skin regeneration, the rational facial mask liquid of cost.
The content of the invention
Based on technical problem existing for background technology, the present invention is ineffective for current anti-sensitive product, it is impossible to from interior
The problem of source regulation is immune, and cost is too high, there is provided a kind of new promotion skin regeneration, antiallergic sense, the facial mask of anti-inflammatory
Liquid.
Trenaxmine is a kind of artificial synthesized amino acid, is a kind of protease inhibitors, and energy protease inhibition is to peptide bond hydrolysis
Catalytic action, so as to prevent the activity of such as inflammatory protease enzyme, and then inhibit the epidermal cell machine at blackspot position
The confusion of energy, and suppress melanin enhancer group, then thoroughly break off occurring because the melanin that ultraviolet irradiates and is formed
Approach.Blackspot is allowed no longer to thicken, expand and increase, so as to effectively prevent and improve the pigment deposition of skin.
Hesperidin methyl is the mixture of water-soluble a variety of flavanone type hesperidin methyls.It can suppress to cause skin darkening
Tyrosinase effect, available for treatment blackspot, the skin disease such as freckle.With the normal permeability of blood vessel is maintained, capillary is improved
Vascular resistance, strengthen the elasticity and toughness of capillary, prevent and treat capillary hemorrhage, bleeding gums etc..
Sensor Chip CM 5 is a kind of cosmetics bio feedstocks for having and starting the effect of skin itself epidemic preventing mechanism, and it passes through
Active cell immune system improves the immunocompetence of skin so as to reach, and protects the synthesis of collagen, improves the elasticity of skin,
Damaged skin is repaired, is diminished inflammation and antiallergy, while also there is photoprotection, the special reparation for being suitable for skin after solarization.
Henon bamboo leaf extract, the lophatherum gracile alias bamboo tuber of dwarf lilyturf, the long leaf of bamboo, pheasant rice etc..For the stem of grass tannin plant lophatherum gracile
Leaf.Lophatherum gracile is containing triterpenoid, phytosterol, chromocor compound, alkaloid, phenols component, polysaccharide etc..Triterpenoid
It is the main component of lophatherum gracile, there is freidelin, arundoin, Cylindrin, alnulin, Tricin, Tricin -7-O- β-D-
Glucoside etc.；Phytosterol has cupreol, stigmasterol, campesterol etc.；Chromocor compound is Vitexin；Alkaloid has
Thymidine, adenine etc.；Phenols component has syringaldehyde, is trans to hydroxyl cinnaldehydrum, vanilla
Aldehyde etc..Herba Lophatheri extract has good inhibitory action to tyrosinase, with reference to suppression of the Herba Lophatheri extract to keratinization enzyme
System, keratinization enzymatic deepen cuticula aging, color and luster, therefore extract can be used for desalinating the colour of skin, eliminate color spot；Lophatherum gracile
Extract has facilitation to rats hair growth, can be respectively used for product for improving hair-growing；The zoopery table of Herba Lophatheri extract
Bright, it has the function of suppressing allergy and itching, can be used as the anti-allergic agent of cosmetics.
Activation of the radix scutellariae extract solution to luciferase and the promotion to interferon secretion, this explanation is to suppressing dermatitis, increase
Skin resistance has effect, has anti-inflammatory.Radix scutellariae extract solution has the ability for neutralizing histamine, so allergy can be prevented and treated.
The red sage root (SALVIA MILTIORRHIZA) root extract, main chemical compositions：Tanshinone IIA, tanshin polyphenolic acid B, hidden pellet
Join ketone：Mainly there is fat-soluble non-quinochrome class compound, such as tanshinone IIA, Tanshinone II B, Cryptotanshinone and its isomers.Water
Dissolubility liposoluble ingredient such as protocatechualdehyde, danshensu.Wherein, Cryptotanshinone and danshensu are the active ingredient of antibacterial, have and live
Blood stagnation resolvation, improve blood circulation effect, also have the effect of fine to pyogenic infections from tumour or sore, acne can be eliminated in cosmetics, anti-acne resists
Acne, containing collagen synthesis inhibitors, pockmark acne pimple can be cured, eliminates scar, improves texture.
Ginger is Zingiber herbaceos perennial ginger (Zingiber officinale Roscoe) new fresh quench stem, not
Name, which has race, hundred peppery clouds, hooks dress refers to, because ground is pungent, hot and cold boy, fresh ginger, honey process ginger.The rhizome (rhizoma zingiberis) of ginger, cork (ginger
Skin), leaf (ginger leaves) can be used as medicine.Ginger has diverging, preventing or arresting vomiting, cough-relieving and other effects in traditional Chinese medicine and pharmacy.Ginger extract is to gold
Staphylococcus aureus, staphylococcus albus, typhoid bacillus, bacterium sonnei, Pseudomonas aeruginosa have obvious inhibiting effect, its
Effect and concentration are in dependence.Especially it is most strong with the inhibitory action of staphylococcus aureus and staphylococcus albus, also have aobvious
The effect of suppressing dermatophyte and killing connections Trichomonas vaginalis is write, various carbuncle sore tumefacting virus can be treated.Skin can be stimulated, promote blood
It can promote hair growth while the effect such as circulation, preventing and treating dandruff.
Hydrolyzed wheat protein, CAS：70084-87-6, wheat oligopeptide are using the protein extracted in wheat as raw material, are adopted
With a variety of enzyme preparations, by orienting the micromolecule polypeptide material of digestion and the acquisition of specific small peptide isolation technics, former albumen is kept to seek
While supporting characteristic, also with the features such as good water solubility, emulsibility, compatibility, easily absorption, bioactivity is strong.Wheat is low
Poly- peptide contains the various amino acid of needed by human body, particularly containing abundant glutamine.And glutamine is pole in compound body
Its important antioxidant --- the precursor substance of reduced glutathione.Therefore, wheat gluten oligopeptide has excellent resist
Oxidability.
Aloe is one kind of sago cycas, aloe it is various in style, wherein fresh extract solution from aloe is most good merchantable brand, it is a kind of magical
Wholefood, medicine, cosmetic additive agent, containing abundant skin-nourishing element, such as vitamin, amino acid, glucoside, choline
The various active compositions such as carbohydrate, compound mucopolysaccharide, protein, mineral matter, biology enzyme, aloin, aloe-emodin.
Chrysanthemum indicum extract solution is the head titbit of feverfew mother chrysanthemum.In the rhamnose grapes of -7- containing robinin glucoside, chrysanthemum indicum
Fat, Chrysanthemin, bitter principle, chrysol, chrysanthone, northern camphor, another material containing retinoid and vitamin B1, have equilibrium
Fat secretion, the effect for suppressing anti-acne, preventing acne, bactericidal antiphlogistic.
The bighead atractylodes rhizome, Classification system Atractylodes macrocephala.Alias small wooden raft Ji, Yu Shu, the winter bighead atractylodes rhizome, wash rice art, poplar
Small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc., belong to catananche.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.
It is distributed mainly on the mountain area such as Sichuan, Yunnan, Guizhou wetland.Its Main Ingredients and Appearance contains volatile oil, atractylol, atractylone and vitamin A,
The main diuresis of its pharmacology, reduce blood glucose, anticoagulant, strong human body and antibacterial action.
In general, ginger is considered as to be not suitable for sensitive skin, because its excitant is bigger, but the present inventor
It was found that in the special prescription, be suitably added ginger on the contrary so that it promotes skin power of regeneration to greatly reinforce, to skin also without
Stimulation.
The present inventor, by updating formula, develops the multicomponent Synergistic on substantial amounts of practical basis,
With immunological regulation, sensitive, the outstanding facial mask liquid of promotion skin regeneration and other effects is repaired.
Technical scheme is as follows：
A kind of facial mask liquid for promoting skin regeneration antiallergic, relative to the gross mass of facial mask liquid, contains following components：
Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%, wheat
Protein hydrolyzate 2%-3%；Henon bamboo leaf extract 0.5%-0.8%；, radix scutellariae extract solution 1%-1.5%, red sage root extract solution
2.3%-3%, ginger extract 0.3%-0.5%, extract solution from aloe 0.5%；Chrysanthemum indicum extract solution 2% -2.5%；The bighead atractylodes rhizome carries
Take liquid 0.2%-0.8%；1,2- hexylene glycol 0.2%-0.3%.
Preferably, in described facial mask liquid, relative to the gross mass of facial mask liquid, following components is also contained：
Transparent xanthan gum 0.05%-0.2%；Hyaluronic acid 0.1%-0.2%, Preservative qs.
The preservative is preferably：Natural antiseptic agent CMG, chemical composition：Fatty acid isomer, SUNSOFT 700P-2.
Preferably, it is composed of the following components relative to the gross mass of facial mask liquid in described facial mask liquid：
Hyaluronic acid 0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat egg
White hydrolyzate 2%；Henon bamboo leaf extract 0.8%；, radix scutellariae extract solution 1.5%, red sage root extract solution 2.3%, ginger extract
0.5%, extract solution from aloe 0.5%；Chrysanthemum indicum extract solution 2%；Bighead atractylodes rhizome extract solution 0.8%；1,2- hexylene glycol 0.3%, water-soluble nitrogen
Ketone 0.5%, natural antiseptic agent CMG 0.5%；Transparent xanthan gum 0.15%.
A kind of preparation method of the facial mask liquid facial mask liquid of promotion skin regeneration antiallergic, comprises the following steps：
(1) heating water to vacuum at 95 DEG C is pumped into emulsification pot, is added under processing condition at transparent xanthan gum homogeneous
Reason 5 minutes；
(2) when temperature is reduced to below 40 DEG C, added into emulsification pot transparent with the gross mass addition of relative facial mask liquid
Matter acid 0.1%-0.2%, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-
0.03%, wheat gluten hydrolyzate 2%-3%；Henon bamboo leaf extract 0.5%-0.8%；, radix scutellariae extract solution 1%-1.5%, pellet
Join root extract solution 2.3%-3%, ginger extract 0.3%-0.5%, extract solution from aloe 0.5%；Chrysanthemum indicum extract solution 2%-
2.5%；Bighead atractylodes rhizome extract solution 0.2%-0.8%；1,2- hexylene glycol 0.2% -0.3%, Preservative qs；
(3) room temperature is down to, completes the preparation to facial mask liquid.
Preferably, in the preparation method of the facial mask liquid of described promotion skin regeneration antiallergic, the hyaluronic acid
0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat gluten hydrolyzate 2%；Henon bamboo
Leaf extract 0.8%；, radix scutellariae extract solution 1.5%, red sage root extract solution 2.3%, ginger extract 0.5%, extract solution from aloe
0.5%；Chrysanthemum indicum extract solution 2%；Bighead atractylodes rhizome extract solution 0.8%；1,2- hexylene glycol 0.3%, water-soluble azone 0.5%, natural anticorrosion
Agent CMG 0.5%；Transparent xanthan gum 0.15%.
The present invention is advantageous in that：
1st, facial mask liquid energy of the invention is really immune from endogenous regulation, anti-inflammatory, and activates the reparation energy of skin itself
Power, using rear skin comfort, without any stimulation, improve erythema.
2nd, facial mask liquid of the invention can significantly promote the generation of POMC derived peptide, and it is obvious calm that this illustrates that it has
Effect, reduce cutaneous sensibility.
3rd, allow TEWL to reduce 20%-31% using the facial mask liquid energy of the present invention, skin can be allowed to have obtained good reparation.
4th, facial mask liquid of the invention has very excellent skin-tolerant, acceptance, nontoxic not sensitization.
5th, facial mask liquid skin sense of the invention is good, using comfortable, substantially increased using rear skin layer thickness, there is core keratinocyte
Quantity also dramatically increase, so as to maintain cuticle state, repair skin barrier function.
Brief description of the drawings
After the facial mask liquid that Fig. 1 is 1-4 of the embodiment of the present invention handles Human Keratinocytes, IL-1 α growing amounts % is relative to right
According to the relation of group.
After the facial mask liquid that Fig. 2 is 1-4 of the embodiment of the present invention handles Human Keratinocytes, TNF-α growing amount % is relative to right
According to the relation of group.
After the facial mask liquid that Fig. 3 is 1-4 of the embodiment of the present invention handles Human Keratinocytes, IL-10 growing amounts % is relative to right
According to the relation of group.
After Fig. 4 is carries out 28 days treatment phases with the facial mask liquid of the embodiment of the present invention, skin histology's picture.
Embodiment
The extract solution that all embodiments of the invention are used is purchased from any company, and many producers are in stock.
Embodiment 1：
A kind of preparation method of the facial mask liquid facial mask liquid of promotion skin regeneration antiallergic, comprises the following steps：
Heating water to vacuum at 95 DEG C is pumped into emulsification pot, and transparent xanthan gum homogenization 5 is added under processing condition
Minute；
When temperature is reduced to below 40 DEG C, is added into emulsification pot and hyaluronic acid is added with the gross mass of relative facial mask liquid
0.15%, Trenaxmine 0.5%, hesperidin methyl 0.1%, Sensor Chip CM 5 0.03%, wheat gluten hydrolyzate 2%；Henon bamboo
Leaf extract 0.8%；, radix scutellariae extract solution 1.5%, red sage root extract solution 2.3%, ginger extract 0.5%, extract solution from aloe
0.5%；Chrysanthemum indicum extract solution 2%；Bighead atractylodes rhizome extract solution 0.8%；1,2- hexylene glycol 0.3%, water-soluble azone 0.5%, natural anticorrosion
Agent CMG 0.5%；
Room temperature is down to, completes the preparation to facial mask liquid.
In the step 1, relative to the gross mass of facial mask liquid, the additional proportion of transparent xanthan gum is 0.15%.
Embodiment 2：
A kind of preparation method of the facial mask liquid facial mask liquid of promotion skin regeneration antiallergic, comprises the following steps：
Heating water to vacuum at 95 DEG C is pumped into emulsification pot, and transparent xanthan gum homogenization 5 is added under processing condition
Minute；
When temperature is reduced to below 40 DEG C, is added into emulsification pot and hyaluronic acid is added with the gross mass of relative facial mask liquid
0.1%, Trenaxmine 1%, hesperidin methyl 0.05%, Sensor Chip CM 5 0.01%, wheat gluten hydrolyzate 3%；Lophatherum gracile
Extract solution 0.5%；, radix scutellariae extract solution 1%, red sage root extract solution 3%, ginger extract 0.3%, extract solution from aloe 0.5%；It is wild
Chrysanthemum extract liquid 2.5%；Bighead atractylodes rhizome extract solution 0.2%；1,2- hexylene glycol 0.2%, water-soluble azone 0.5%, natural antiseptic agent
CMG0.2%；
Room temperature is down to, completes the preparation to facial mask liquid.
In the step 1, relative to the gross mass of facial mask liquid, the additional proportion of transparent xanthan gum is 0.2%.
Embodiment 3：
A kind of preparation method of the facial mask liquid facial mask liquid of promotion skin regeneration antiallergic, comprises the following steps：
Heating water to vacuum at 95 DEG C is pumped into emulsification pot, and transparent xanthan gum homogenization 5 is added under processing condition
Minute；
When temperature is reduced to below 40 DEG C, is added into emulsification pot and hyaluronic acid is added with the gross mass of relative facial mask liquid
0.2%, Trenaxmine 0.8%, hesperidin methyl 0.06%, Sensor Chip CM 5 0.02%, wheat gluten hydrolyzate 2%；Henon bamboo
Leaf extract 0.7%；, radix scutellariae extract solution 1.3%, red sage root extract solution 2.6%, ginger extract 0.4%, extract solution from aloe
0.5%；Chrysanthemum indicum extract solution 2.2%；Bighead atractylodes rhizome extract solution 0.5%；1,2- hexylene glycol 0.3%, water-soluble azone 0.5% are natural anti-
Rotten agent CMG 0.4%；
Room temperature is down to, completes the preparation to facial mask liquid.
In the step 1, relative to the gross mass of facial mask liquid, the additional proportion of transparent xanthan gum is 0.08%.
Embodiment 4：
A kind of preparation method of the facial mask liquid facial mask liquid of promotion skin regeneration antiallergic, comprises the following steps：
Heating water to vacuum at 95 DEG C is pumped into emulsification pot, and transparent xanthan gum homogenization 5 is added under processing condition
Minute；
When temperature is reduced to below 40 DEG C, is added into emulsification pot and hyaluronic acid is added with the gross mass of relative facial mask liquid
0.1%, Trenaxmine 0.6%, hesperidin methyl 0.09%, Sensor Chip CM 5 0.03%, wheat gluten hydrolyzate 3%；Henon bamboo
Leaf extract 0.6%；, radix scutellariae extract solution 1.2%, red sage root extract solution 2.9%, ginger extract 0.5%, extract solution from aloe
0.5%；Chrysanthemum indicum extract solution 2.4%；Bighead atractylodes rhizome extract solution 0.7%；1,2- hexylene glycol 0.2%, water-soluble azone 0.5% are natural anti-
Rotten agent CMG 0.3%；
Room temperature is down to, completes the preparation to facial mask liquid.
In the step 1, relative to the gross mass of facial mask liquid, the additional proportion of transparent xanthan gum is 0.05%.
Embodiment 5：
The test of the present embodiment is carried out in Shandong Province Rizhao City Ou Zi cosmetics Co., Ltd laboratory.
(1) ion vitro immunization regulation active testing
IL-1 α and TNF-α are all proinflammatory factors, and IL-10 is immunosuppressive factor, is increased with advancing age.
Under the conditions of light irradiation, it is small that keratinocyte 72 is handled in the DMEM without serum with the facial mask liquid of the present embodiment
When, control group is blank control group.
As a result show, under light illumination IL-1 α, TNF-α, IL-10 growing amount all steeply rises, but uses the present embodiment
After facial mask liquid processing, its growing amount substantially reduces than control group, as a result as illustrated in the accompanying drawings from 1 to 3.This shows, under light illumination, this
Generation of the facial mask liquid of invention to such factor in Human Keratinocytes' culture has significant regulating and controlling effect, there is anti-inflammatory effect
Fruit.The especially facial mask liquid of embodiment 1, it is maximum compared to control group down ratio.Thus it may determine that, facial mask liquid of the invention can
To promote skin homeostasis by immunoregulatory method.
CGRP is the most strong expansion angiogenic substance being currently known, and there is lower hypotensive, peripheral resistance reduction, the arteria renalis to relax
Open, renal blood flow substantially increased effect.CGRP also has powerful diastole effect to coronary artery, to the coronal dynamic of atherosis
Arteries and veins is also effective, and its diastole effect is about stronger 240 times than nitroglycerin, sodium nitroprussiate, and this diastole is acted on independent of blood vessel endothelium
In the presence of also not influenceed by A, B and 5-hydroxytryptamine receptor blocking agent, illustrate that CGRP is incorporated into specific CGRP acceptors.CGRP
The reduction of coronary artery perfusion pressure can also be made, coronary blood flow substantially increases, heart rate, and myocardial contractive power enhancing, CGRP has obvious
Positive inotropic and positive chronotropic action, this effect is strong compared with norepinephrine, but can be cancelled by B ARBs, its machine
System may be relevant with cAMP levels in rise cardiac muscle cell.CGRP antiarrhythmic effect is about stronger by 220 than calcium-channel antagonists
Times, its mechanism of action is probably the interior stream for adjusting cardiac muscle cell.CGRP has obvious diastole to act on to all blood vessels, and it is made
With strong compared with materials such as acetylcholines.
Under UV stimulations, act on keratinocyte culture, embodiment 1-4 facial mask liquid is additionally observed that and can reduced
CGRP, which is formed, reaches 40%, 25%, 20%, 26%, and this proves that the facial mask liquid is for a very important Anti-inflammatory Mechanism
There is positive effect, that is, it can reduce the sensory nerve signal of sensitiveness skin, can adjust endogenous immunocompetence.
Moreover, it has been found that the facial mask liquid of the present invention can significantly promote the generation of POMC derived peptide, this illustrates its tool
There is the effect of obvious calmness, reduce cutaneous sensibility, maintain skin tissue's integrality and mitigate skin ageing phenomenon.
(2) volunteer's actual test
100 sensitiveness skin testers (test and determine through excitant), the range of age：40-55 year, it is divided into 5 groups, every group
20 testers, there was no significant difference between each group.Silk mask made of embodiment 1-4 facial mask liquid is used daily,
Each application 20 minutes, is used 28 days.Control group uses placebo facial mask, only with replenishing water and preserving moisture effect.
The reparation and maintenance of skin generally can produce qualitative change to sensitive essence.TEWL(TewameterTM,
Courage-Khazaka), percutaneous moisture is assessed through (TEWL) and found, TEWL reduces 20%-31% after 28 days.This is proved
Skin has obtained good reparation.
Other results are as shown in table 1：
Table 1
As can be seen here, facial mask liquid energy of the invention significantly improves skin feel, reduces erythema, and enhancing skin is fitted to stimulation
Stress, improve dry skin.Moreover, it has been found that facial mask liquid of the invention has certain whitening effect.
In addition, carrying out skin histology's inspection, as shown in Figure 4, after 28 days treatment phases, skin layer thickness substantially increases,
The quantity for having core keratinocyte also dramatically increases, and so as to maintain cuticle state, repairs skin barrier function.
It can be seen that facial mask liquid of the invention has extraordinary improvement result to sensitive skin.
(3) toxicology is tested
Toxicology test is carried out from mouse, as a result：
Under 25% aqueous solution：
Acute oral toxicity：It is nontoxic
Eye irritation：It is resistant to very much
Sensitization test (STT)：Without sensitization
Single epidermis patch test：Fabulous tolerance
To 3T3-NRU 3T3 fibroblast red untakes Phototoxicity experiments (assessment phototoxicity)：Without phototoxicity.
As a result show, facial mask liquid of the invention has very excellent skin-tolerant, acceptance, nontoxic not sensitization.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (2)
1. one kind promotes skin regeneration antiallergic, have and adjust endogenous immunocompetent facial mask liquid, it is characterised in that：Relative to face
The gross mass of film liquid, contains following components：
Hyaluronic acid 0.1%-0.2%, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5
0.01%-0.03%, wheat gluten hydrolyzate 2%-3%, henon bamboo leaf extract 0.5%-0.8%, radix scutellariae extract solution 1%-
1.5%, red sage root extract solution 2.3%-3%, ginger extract 0.3%-0.5%, extract solution from aloe 0.5%, chrysanthemum indicum extraction
Liquid 2%-2.5%, the bighead atractylodes rhizome extract solution 0.2%-0.8%, 1,2- hexylene glycol 0.2%-0.3%.
2. one kind promotes skin regeneration antiallergic, the preparation method of endogenous immunocompetent facial mask liquid is adjusted, is comprised the following steps：
(1) heating water to vacuum at 95 DEG C is pumped into emulsification pot, and transparent xanthan gum homogenization is added under processing condition；
(2) when temperature is reduced to below 40 DEG C, added into emulsification pot and hyaluronic acid is added with the gross mass of relative facial mask liquid
0.1%-0.2%, Trenaxmine 0.5%-1%, hesperidin methyl 0.05%-0.1%, Sensor Chip CM 5 0.01%-0.03%,
Wheat gluten hydrolyzate 2%-3%, henon bamboo leaf extract 0.5%-0.8%, radix scutellariae extract solution 1%-1.5%, red sage root extraction
Liquid 2.3%-3%, ginger extract 0.3%-0.5%, extract solution from aloe 0.5%, chrysanthemum indicum extract solution 2%-2.5%, the bighead atractylodes rhizome
Extract solution 0.2%-0.8%, 1,2- hexylene glycol 0.2%-0.3%, Preservative qs；
(3) room temperature is down to, completes the preparation to facial mask liquid.
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| CN110731912A (en) * | 2019-11-20 | 2020-01-31 | 广州瑞誉化工科技有限公司 | whitening and anti-aging essence |
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