CN106236619A - The extracting method of a kind of Aloe and Aloe acne eliminating cream - Google Patents

The extracting method of a kind of Aloe and Aloe acne eliminating cream Download PDF

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Publication number
CN106236619A
CN106236619A CN201610602275.1A CN201610602275A CN106236619A CN 106236619 A CN106236619 A CN 106236619A CN 201610602275 A CN201610602275 A CN 201610602275A CN 106236619 A CN106236619 A CN 106236619A
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China
Prior art keywords
aloe
cylinder
swingle
hothouse
roof
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卞毓平
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/0011—Heating features
    • B01D1/0017—Use of electrical or wave energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/30—Accessories for evaporators ; Constructional details thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/402—Mixers using gas or liquid agitation, e.g. with air supply tubes comprising supplementary stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B23/00—Heating arrangements
    • F26B23/04—Heating arrangements using electric heating
    • F26B23/06—Heating arrangements using electric heating resistance heating
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

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  • Chemical Kinetics & Catalysis (AREA)
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Abstract

The present invention provides the extracting method of a kind of Aloe, takes fresh aloe, cleans after rubbing, adding ethanol makes the percent by volume of alcohol content reach 75%, stirs, stands 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtain concentrated solution, use supercritical extraction, obtain supercritical extract, continue to concentrate, concentrated solution is dried, obtains Aloe extract, prepare emodin content high, and be prepared as Aloe acne eliminating cream with cryptotanshinone, Hesperidin compatibility.

Description

The extracting method of a kind of Aloe and Aloe acne eliminating cream
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to extracting method and the Aloe acne eliminating cream of a kind of Aloe.
Background technology
Aloe extracting method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient to use Measure excessive, it has not been convenient to take, had a strong impact on this product and applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide extracting method and the reed of a kind of Aloe Luxuriant growth acne eliminating cream.
Technical scheme: it is an object of the invention to by following scheme realization:
The extracting method of a kind of Aloe, preparation method is: take fresh aloe, cleans after rubbing, adds ethanol and make alcohol content Percent by volume reaches 75%, stirs, stands 24 hours, filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims second Alcohol, obtains concentrated solution, uses supercritical extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, obtains Aloe and carry Take thing.
The extracting method of described Aloe, joins CO by concentrated solution in preparation method2In supercritical extraction device, ethanol conduct Entrainer, it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO2 Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, and optimum condition is: described CO2Surpass and face It is 5% that boundary's extraction entrainer accounts for the percent by volume of total extractant, described CO2Extracting pressure 20MPa of supercritical extraction, temperature Spend 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
The extracting method of described Aloe, concentrates in said extracted method and uses device, including concentrating cylinder, is arranged on described Concentrate the vaporizer of cylinder body bottom, be provided with venthole at the top of described concentration cylinder and condense panel, at described condensation panel Inside be provided with cooling liquid storage chamber, be provided with at the top of described concentration cylinder with the described cooling liquid storage feed tube that is connected of chamber and Discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, and described swingle is provided with Scraper dish, the web of described scraper dish contacts with the inwall concentrating cylinder, is provided with on the roof of described concentration cylinder Lift cylinder, the top of described swingle is connected through roof and the top of described concentration cylinder with described lift cylinder, Being provided with electric rotating machine in described swingle, the main shaft of described electric rotating machine is connected with the center of described scraper dish, described The top concentrating cylinder is additionally provided with the elevating lever through roof, is provided with horn-like suction in the bottom of described elevating lever and steeps mouth, in institute It is provided with in stating elevating lever and steeps, with described horn-like suction, the suction bubble passage that mouth is connected, be provided with adsorption pump at the top of described elevating lever Body, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, and described elevating lever is at described regulation cylinder Effect under in described concentration cylinder, do lifting moving.
The extracting method of described Aloe, the sidewall concentrating cylinder in said extracted method described in enrichment facility is provided with observation Window, is provided with seal glass in described observation window, and described scraper dish is circular, the external diameter of described scraper dish and concentration cylinder Identical and scraper dish the inner ring surface of the internal diameter of body is connected with the main shaft of electric rotating machine by dowel bar, and described vaporizer is Columnar structured, described vaporizer is connected to concentrate the diapire of cylinder by adpting flange, is provided with evaporation in described vaporizer Pipe, is provided with the steam inlet being connected with described evaporation tube and steam (vapor) outlet on the sidewall of described vaporizer.
The extracting method of described Aloe, is dried in said extracted method and uses device, including hothouse and described hothouse The air quantity conditioning chamber being connected, is provided with charging aperture on the roof of described hothouse, is provided with discharging in the bottom of described hothouse Mouthful, described air quantity conditioning chamber is provided with air intake passage, described hothouse is provided with air exhaust passage, it is characterised in that: in institute State and be provided with dividing plate between air quantity conditioning chamber and described hothouse, described dividing plate is uniformly provided with pore, on described dividing plate also Being provided with the cavity of lateral opening, described cavity is arranged on the side by hothouse, is provided with electric rotating machine, also sets in described cavity There is the swingle being connected with described electric rotating machine main shaft, be provided with upset paddle, described rotation on the surface of described swingle Bar stretches in described hothouse, is provided with air guide channel at the center of described swingle, is uniformly provided with on described upset paddle The hot gas injection jets being connected with described air guide channel, when described wind is stretched in the end of described swingle in conditioning chamber, leads described It is provided with heat conduction blower fan in gas passage, is provided with movable plate when described wind in conditioning chamber, be provided with and institute in the side of described movable plate State the air quantity adjusting plug that pore matches and the air holes being arranged between adjacent air quantity adjusting plug, at described movable plate and described wind Mobile regulation cylinder it is provided with between the sidewall of amount conditioning chamber.
The extracting method of described Aloe, is dried in said extracted method and uses the roof of described air quantity conditioning chamber described in device Being provided with chute, the diapire at described air quantity conditioning chamber is provided with shifting chute, and described shifting chute is consistent with the trend of described chute, described The top of movable plate is movably arranged in described chute by scroll wheel, and the bottom of described movable plate is arranged by movable block activity In described shifting chute, described mobile regulation cylinder is arranged between described movable block and the end wall of shifting chute.
The extracting method of described Aloe, is dried in said extracted method and uses the main shaft of electric rotating machine described in device to be provided with Driving fluted disc, be provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, the opening part of described cavity is provided with anti- Protecting wire net, described swingle is arranged through described protection network.
A kind of Aloe acne eliminating cream, said method the Aloe extract prepared, cryptotanshinone, Hesperidin form.
Described Aloe acne eliminating cream, Aloe extract, cryptotanshinone, the weight ratio of Hesperidin are 4-8:1-3:2-4.
Described Aloe acne eliminating cream, Aloe extract, cryptotanshinone, the weight ratio of Hesperidin are 6:2:3.
In prior art, the original extracting method of Aloe, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, no Conveniently taking, emodin content prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation are just Victory, it not only can start scraper dish as required and do lift adjustment as required such that it is able to realize concentrating cylinder Inwall carries out scraping dirt process, and the descending operation that simultaneously can also regulate elevating lever as required makes horn-like bubble mouth of inhaling be in medicine Being absorbed by the foam on surface by the absorption pump housing just above of liquid level, solves tube wall medicine dirt in conventional art medicine enrichment facility Removing the technical deficiency of difficulty, stability in use is good and the suitability is strong.This drying equipment structure is simple, simple operation, is provided with and turns over Turning paddle and be provided with, in upset paddle, the hot gas injection jets being connected with air quantity conditioning chamber, it is right to make while stirring medical material Medical material is dried, and adds the speed contacted with medical material, can effectively improve medicinal material drying efficiency, and stability in use Good, solve the technical deficiency that conventional art pharmaceutical drying device drying efficiency is low, the suitability is strong and practicality good.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal Belong to the scope of the present invention.
Embodiment 1
Take fresh aloe 1000g, clean after rubbing, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction Take, obtain supercritical extract, continue to concentrate, concentrated solution is dried, obtains Aloe extract.
Described supercritical extraction method is: joined by concentrated solution in CO2 supercritical extraction device, ethanol as entrainer, It is 4% that entrainer accounts for the percent by volume of total extractant, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/g crude drug Min, extraction time 150min, obtain supercritical extract.
Seeing Fig. 1: the extracting method of described Aloe, above-mentioned concentration uses device, including concentrating cylinder 1, is arranged on described dense Vaporizer 2 bottom contracting cylinder 1, is provided with venthole 3 and condenses panel 4, at described condensation front at the top of described concentration cylinder 1 It is provided with cooling liquid storage chamber 5 in plate 4, is provided with at the top of described concentration cylinder 1 and entering that described cooling liquid storage chamber 5 is connected Liquid pipe 6 and discharge pipe 7, be provided with condensation panel, the gas partial coagulation of medicine evaporation at night can be become moisture, be possible to prevent medicine to wave Sending out, the roof in described concentration cylinder 1 is provided with the swingle 8 downwardly extended, and described swingle 8 is provided with scraper dish 9, The web of described scraper dish 9 contacts with the inwall concentrating cylinder 1, is provided with lifting air on the roof of described concentration cylinder 1 Cylinder 10, the top of described swingle 8 is connected through roof and the top of described concentration cylinder 1 with described lift cylinder 10, Being provided with electric rotating machine 11 in described swingle 8, the main shaft of described electric rotating machine 11 is connected with the center of described scraper dish 9, It is additionally provided with the elevating lever 12 through roof at the top of described concentration cylinder 1, is provided with horn-like in the bottom of described elevating lever 12 Inhale bubble mouth 13, be provided with in described elevating lever 12 and steep the suction bubble passage 14 that mouth 13 is connected, at described liter with described horn-like suction The top of fall bar 12 is provided with the absorption pump housing 15, is provided with regulation gas between the roof and described elevating lever 12 of described concentration cylinder 1 Cylinder 16, described elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
The sidewall of described concentration cylinder 1 is provided with observation window 17, in described observation window, is provided with seal glass 18.
Described scraper dish is circular, the external diameter of described scraper dish with concentrate cylinder internal diameter is identical and scraper dish Inner ring surface be connected with the main shaft of electric rotating machine by dowel bar.It is not to carry out owing to scraping dirt and inhaling bubble simultaneously, so Both can't cause mutually restriction.
Described vaporizer 2 is columnar structured, and described vaporizer 2 is connected to concentrate the end of cylinder 1 by adpting flange 19 Wall, is provided with evaporation tube 20 in described vaporizer, is provided with and is connected with described evaporation tube 20 on the sidewall of described vaporizer 2 Steam inlet 21 and steam (vapor) outlet 22.
Seeing Fig. 2: the extracting method of described Aloe, above-mentioned dry use device, including including hothouse 1 and described being dried The air quantity conditioning chamber 2 that room 1 is connected, is provided with charging aperture 3 on the roof of described hothouse 1, sets in the bottom of described hothouse 1 There is discharging opening 4, described air quantity conditioning chamber 2 is provided with air intake passage 5, described hothouse 1 is provided with air exhaust passage 6, in institute State and between air quantity conditioning chamber 2 and described hothouse 1, be provided with dividing plate 7, described dividing plate 7 is uniformly provided with pore 8, at described dividing plate Being additionally provided with the cavity 9 of lateral opening on 7, described cavity 9 is arranged on the side by hothouse 1, is provided with rotation in described cavity 9 Motor 10, is additionally provided with the swingle 11 being connected with described electric rotating machine 10 main shaft, is provided with on the surface of described swingle 11 and turns over Turning paddle 12, described swingle 11 stretches in described hothouse 1, is provided with air guide channel 13 at the center of described swingle 11, Described upset paddle 12 is uniformly provided with the hot gas injection jets 14 being connected with described air guide channel 13, described swingle 11 When described wind is stretched in end in conditioning chamber 2, in described air guide channel 13, it is provided with heat conduction blower fan 15, the conditioning chamber 2 when described wind Inside it is provided with movable plate 16, is provided with the air quantity adjusting plug 17 matched with described pore 8 in the side of described movable plate 16 and arranges Air holes 18 between adjacent air quantity adjusting plug, is provided with shifting between the sidewall of described movable plate 16 and described air quantity conditioning chamber 2 Dynamic regulation cylinder 19.
Roof at described air quantity conditioning chamber 2 is provided with chute 20, and the diapire at described air quantity conditioning chamber 2 is provided with shifting chute 21, described shifting chute 21 is consistent with the trend of described chute 20, and the top of described movable plate 16 is arranged by scroll wheel 22 is movable In described chute 20, the bottom of described movable plate 16 is movably arranged in described shifting chute 21 by movable block 23, described shifting Dynamic regulation cylinder 19 is arranged between described movable block 23 and the end wall of shifting chute 21.
The main shaft of described electric rotating machine is provided with driving fluted disc 24, described swingle is provided with and described driving fluted disc Mutually ratcheting teeth groove 25.
Opening part at described cavity is provided with protection network 26, and described swingle is arranged through described protection network.
Take Aloe extract that said method prepares, cryptotanshinone, the weight ratio of Hesperidin are 6:2:3, routinely Method is prepared as cream.
Embodiment 2
Take fresh aloe 1000g, clean after rubbing, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction Take, obtain supercritical extract, continue to concentrate, concentrated solution is dried, obtains Aloe extract.
Described supercritical extraction method is: joined by concentrated solution in CO2 supercritical extraction device, ethanol as entrainer, It is 6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/g crude drug Min, extraction time 180min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Take Aloe extract that said method prepares, cryptotanshinone, the weight ratio of Hesperidin are 6:1:4, routinely Method is prepared as cream.
Embodiment 3
Take fresh aloe 1000g, clean after rubbing, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction Take, obtain supercritical extract, continue to concentrate, concentrated solution is dried, obtains Aloe extract.
Described supercritical extraction method is: joined by concentrated solution in CO2 supercritical extraction device, ethanol as entrainer, It is 5% that entrainer accounts for the percent by volume of total extractant, extracting pressure 20MPa of described CO2 supercritical extraction, temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Take Aloe extract that said method prepares, cryptotanshinone, the weight ratio of Hesperidin are 6:3:2, routinely Method is prepared as cream.
In above-described embodiment, cryptotanshinone (30%), Hesperidin (40%) are purchased from bio tech ltd of AOC, Shaanxi.
Embodiment 4: by method preparation in embodiment 1 without the Aloe acne eliminating cream of cryptotanshinone.
Embodiment 5: by method preparation in embodiment 1 without the Aloe acne eliminating cream of Hesperidin.
Embodiment 6: emodin content determination experiment research data in Aloe acne eliminating cream of the present invention
1.1 Experimental agents: Aloe acne eliminating cream of the present invention: prepare by embodiment 1-3 method.Matched group is that Aloe uses commonly Concentrate and be prepared by drying means, take Aloe extract that said method prepares, cryptotanshinone, the weight ratio of Hesperidin are 6: 2:3, is prepared as cream according to a conventional method.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump； Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column be Shim-Pack C18 (4.6mm × 250mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability: Chromatographic column: Shim-Pack C18 (4.6mm × 250mm, 5 μm)；Flowing phase: methanol-0.1% phosphoric acid solution (80: 20)；Flow velocity: 1.0ml/ point；Detection wavelength: 254nm；Column temperature 40 DEG C；Sample size 10 μ l.Number of theoretical plate is calculated should be not less than by rheum emodin peak 2000.Take rheum emodin reference substance appropriate, accurately weighed, add methanol and make every lml solution containing 5ug, to obtain final product.Need testing solution Preparation takes this product under content uniformity item, finely ground, takes about 0.5g, accurately weighed, puts in 25ml measuring bottle, adds methanol 20ml, ultrasonic Process (power 250W, frequency 40kHz) 30 minutes, let cool, add methanol to scale, shake up, filter, take subsequent filtrate, to obtain final product.Respectively Accurate reference substance solution of drawing injects chromatograph of liquid with each 20ul of need testing solution, measures, to obtain final product.
1.4 experimental result
Emodin content measurement result in Aloe acne eliminating cream prepared by each embodiment
Sample source Emodin content (%)
Embodiment 1 3.8
Embodiment 2 4.5
Embodiment 3 3.9
Matched group 1.2
According to the result of the test of upper table, in Aloe acne eliminating cream prepared by embodiment of the present invention 1-3, emodin content is bright Aobvious higher than matched group.
Embodiment 7: clinical observation
Physical data: all case ages 15～34 years old, 28.3 years old mean age, the course of disease 6 months-3 years, average course of disease 1.7 year.Totally 75 example, uses random number method, patient is randomly divided into three groups, respectively embodiment 1,4,5 groups, through statistics credit Analysis, above three groups of cases in terms of sex, age, the state of an illness, no significant difference (P ＞ 0.05), there is comparability.
Diagnostic criteria: (1) diagnosis is with reference to " clinical dermatology ", " People's Republic of China's traditional Chinese medicine industry standard-traditional Chinese medical science Skin disease Standardization of diagnosis and curative effect ": having typical clinical symptoms and sign, skin lesion predominantly involves the being dispersed in property of facial area Blackhead, inflamed papules, pustule, tuberosity, cyst, be diagnosed as acne person.(2) exclusion standard: 1. with infectious disease person, As: hepatitis, syphilis, acquired immune deficiency syndrome (AIDS) etc.；2. can not chronotherapeutic person on demand；3. the person that accepts other treatment in therapeutic process.
Therapeutic Method: treatment group use cream of the present invention smear, every day potion, three times on the one.
Criterion of therapeutical effect: formulate " Chinese medicine (new drug) guideline of clinical investigations " with reference to Ministry of Health of the People's Republic of China: fully recover from an illness More: facial acne erythra all disappears, and occurs without new breakout, only stays pigmentation；Effective: acne deflorescence 70% with On, inflammation substantially alleviates, and occurs without new erythra；Effective: acne erythra substantially disappears 20%-70%, there is a small amount of new erythra to occur； Invalid: acne erythra substantially disappears 20%, or still has new erythra to occur.
Therapeutic outcome: 75 triers are respectively adopted the prepared acne eliminating cream of above-described embodiment 1,4,5 and use continuously 30 days, with The number of number is index, checks the performance of acne eliminating cream of the present invention.It is as shown in the table for result.Aloe and cryptotanshinone, Pericarpium Citri junoris are described Glycosides effect significantly improves.
Trial effect

Claims (10)

1. the extracting method of an Aloe, it is characterised in that preparation method is: take fresh aloe, cleans after rubbing, adds ethanol and make The percent by volume of alcohol content reaches 75%, stirs, stands 24 hours, filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, And reclaim ethanol, obtain concentrated solution, use supercritical extraction, obtain supercritical extract, continue to concentrate, concentrated solution is dried, Obtain Aloe extract.
The extracting method of Aloe the most according to claim 1, it is characterised in that in preparation method, concentrated solution is joined CO2Super In critical extractor, ethanol is as entrainer, and it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15- 30MPa, temperature 30-50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, Optimum condition is: described CO2It is 5% that supercritical extraction entrainer accounts for the percent by volume of total extractant, described CO2Supercritical Extracting pressure 20MPa of extraction, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
The extracting method of Aloe the most according to claim 1, it is characterised in that concentrate in said extracted method and use device, bag Include concentration cylinder, be arranged on the vaporizer of described concentration cylinder body bottom, be provided with venthole at the top of described concentration cylinder and coagulate Junction plate, is provided with cooling liquid storage chamber in described condensation panel, is provided with and described cooling liquid at the top of described concentration cylinder The storage feed tube that is connected of chamber and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with and downwardly extends Swingle, described swingle is provided with scraper dish, and the web of described scraper dish contacts, in institute with the inwall concentrating cylinder State and concentrate the roof of cylinder and be provided with lift cylinder, the top of described swingle through the roof of described concentration cylinder and top with Described lift cylinder is connected, and is provided with electric rotating machine, the main shaft of described electric rotating machine and described scraper in described swingle The center of dish is connected, and is additionally provided with the elevating lever through roof at the top of described concentration cylinder, in the bottom of described elevating lever It is provided with horn-like suction and steeps mouth, be provided with in described elevating lever and steep the suction bubble passage that mouth is connected, described with described horn-like suction The top of elevating lever is provided with the absorption pump housing, is provided with regulation cylinder, institute between the roof and described elevating lever of described concentration cylinder State elevating lever and in described concentration cylinder, do lifting moving under the effect of described regulation cylinder.
The extracting method of Aloe the most according to claim 3, it is characterised in that dense described in enrichment facility in said extracted method The sidewall of contracting cylinder is provided with observation window, is provided with seal glass in described observation window, and described scraper dish is circular, described Identical with the internal diameter concentrating cylinder and scraper dish the inner ring surface of the external diameter of scraper dish passes through dowel bar and electric rotating machine Main shaft is connected, and described vaporizer is columnar structured, and described vaporizer is connected to concentrate the diapire of cylinder by adpting flange, In described vaporizer, it is provided with evaporation tube, the sidewall of described vaporizer is provided with the steam inlet being connected with described evaporation tube And steam (vapor) outlet.
The extracting method of Aloe the most according to claim 1, it is characterised in that be dried in said extracted method and use device, bag Include the air quantity conditioning chamber that hothouse is connected with described hothouse, the roof of described hothouse is provided with charging aperture, described The bottom of hothouse is provided with discharging opening, is provided with air intake passage, is provided with air draft on described hothouse on described air quantity conditioning chamber Passage, it is characterised in that: between described air quantity conditioning chamber and described hothouse, it is provided with dividing plate, described dividing plate is uniformly provided with Pore, is additionally provided with the cavity of lateral opening on described dividing plate, and described cavity is arranged on the side by hothouse, at described cavity Inside it is provided with electric rotating machine, is additionally provided with the swingle being connected with described electric rotating machine main shaft, is provided with on the surface of described swingle Upset paddle, described swingle stretches in described hothouse, is provided with air guide channel at the center of described swingle, turns over described Turn and on paddle, be uniformly provided with the hot gas injection jets being connected with described air guide channel, when described wind is stretched in the end of described swingle In conditioning chamber, in described air guide channel, it is provided with heat conduction blower fan, is provided with movable plate when described wind in conditioning chamber, in described movement The side of plate is provided with described pore matches air quantity adjusting plug and the air holes being arranged between adjacent air quantity adjusting plug, in institute State and between the sidewall of movable plate and described air quantity conditioning chamber, be provided with mobile regulation cylinder.
The extracting method of Aloe the most according to claim 5, it is characterised in that be dried in said extracted method and use device institute The roof stating described air quantity conditioning chamber is provided with chute, and the diapire at described air quantity conditioning chamber is provided with shifting chute, described shifting chute with The trend of described chute is consistent, and the top of described movable plate is movably arranged in described chute by scroll wheel, described movable plate Bottom be movably arranged in described shifting chute by movable block, described mobile regulation cylinder is arranged on described movable block and movement Between the end wall of groove.
The extracting method of Aloe the most according to claim 5, it is characterised in that be dried in said extracted method and use device institute The main shaft stating electric rotating machine is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, The opening part of described cavity is provided with protection network, and described swingle is arranged through described protection network.
8. an Aloe acne eliminating cream, it is characterised in that by the Aloe extract prepared in claim 1, cryptotanshinone, orange Skin glycosides forms.
Aloe acne eliminating cream the most according to claim 8, it is characterised in that Aloe extract, cryptotanshinone, the weight of Hesperidin Ratio is 4-8:1-3:2-4.
Aloe acne eliminating cream the most according to claim 9, it is characterised in that Aloe extract, cryptotanshinone, the weight of Hesperidin Ratio is 6:2:3.
CN201610602275.1A 2016-07-27 2016-07-27 The extracting method of a kind of Aloe and Aloe acne eliminating cream Pending CN106236619A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104644510A (en) * 2015-03-04 2015-05-27 袁丽丽 Anti-allergic facial mask fluid for promoting skin regeneration

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104644510A (en) * 2015-03-04 2015-05-27 袁丽丽 Anti-allergic facial mask fluid for promoting skin regeneration

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
朱俊玲等: "超临界CO2流体萃取芦荟大黄素的研究", 《食品工业》 *
高梦祥等: "超临界流体萃取技术分离芦荟有效成分的可行性研究", 《粮油加工与食品机械》 *

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Application publication date: 20161221