CN106075360A - A kind of invigorating spleen prescription compositions - Google Patents
A kind of invigorating spleen prescription compositions Download PDFInfo
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- CN106075360A CN106075360A CN201610606667.5A CN201610606667A CN106075360A CN 106075360 A CN106075360 A CN 106075360A CN 201610606667 A CN201610606667 A CN 201610606667A CN 106075360 A CN106075360 A CN 106075360A
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- cylinder
- swingle
- invigorating spleen
- rhizoma
- hothouse
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- 210000000952 spleen Anatomy 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000012141 concentrate Substances 0.000 claims abstract description 14
- 239000012567 medical material Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 241000218176 Corydalis Species 0.000 claims abstract description 7
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 7
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 210000000582 semen Anatomy 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 238000007796 conventional method Methods 0.000 claims abstract description 5
- 230000003750 conditioning effect Effects 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 21
- 230000003028 elevating effect Effects 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 19
- 239000006200 vaporizer Substances 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 239000000110 cooling liquid Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 3
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 201000005917 gastric ulcer Diseases 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 abstract description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
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- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
nullThe present invention provides a kind of invigorating spleen prescription compositions，Take Herba Pogostemonis 10g、Ramulus Cinnamomi 10g、Rhizoma Atractylodis Macrocephalae 10g、Radix Paeoniae Alba 15g、Fructus Amomi 6g、Rhizoma Chuanxiong 6g、Herba Eupatorii 10g、Rhizoma Zingiberis 3g、Rhizoma Cyperi 10g、Rhizoma Corydalis 10g、Radix Aucklandiae 10g、Caulis Perillae 10g、Poria 10g、Radix Linderae 10g、Radix Puerariae 10g、Semen Coicis 10g，Add the water of 10 times of weight of medical material，Soak 0.5h，Decoct 1 hour，Filter，Medicinal residues add the water of 8 times of weight of medical material，Decoct 1 hour，Medicinal liquid leaches，Merge twice decoction liquor，Being concentrated into 60 DEG C of relative densities is 1.05，Adding ethanol makes the percent by volume of alcohol content reach 75%，Stirring，Stand，Filter，When filtrate is concentrated into 65 DEG C, relative density is 1.25，And reclaim ethanol，Obtain concentrated solution，Use supercritical extraction，Obtain supercritical extract，Continue to concentrate，Concentrated solution is dried,It is prepared as invigorating spleen prescription compositions by conventional method，Prepare ligustrazine content high.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of invigorating spleen prescription compositions.
Background technology
Traditional Chinese medicine extraction method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient to use
Measure excessive, it has not been convenient to take, had a strong impact on this product and applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of invigorating spleen prescription compositions.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of invigorating spleen prescription compositions, preparation method is: take Herba Pogostemonis 10g, Ramulus Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Fructus Amomi
6g, Rhizoma Chuanxiong 6g, Herba Eupatorii 10g, Rhizoma Zingiberis 3g, Rhizoma Cyperi 10g, Rhizoma Corydalis 10g, Radix Aucklandiae 10g, Caulis Perillae 10g, Poria 10g, Radix Linderae 10g, Radix Puerariae
10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weights of medical material
The water of amount, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes to contain
The percent by volume of alcohol amount reaches 75%, and stirring, standing, filtration, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims second
Alcohol, obtains concentrated solution, uses supercritical extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, uses routine side
Method is prepared as invigorating spleen prescription compositions.
Described invigorating spleen prescription compositions, joins CO by water extract-alcohol precipitation concentrated solution in preparation method2In supercritical extraction device,
Ethanol is as entrainer, and it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15-30MPa, temperature 30-
50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, and optimum condition is: institute
State CO2It is 5% that supercritical extraction entrainer accounts for the percent by volume of total extractant, described CO2The extracting pressure of supercritical extraction
20MPa, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
Described invigorating spleen prescription compositions, in said extracted method, twice concentration uses device, including concentrating cylinder, is arranged on
The vaporizer of described concentration cylinder body bottom, is provided with venthole and condenses panel, in described condensation at the top of described concentration cylinder
It is provided with cooling liquid storage chamber in panel, is provided with the feed liquor being connected with described cooling liquid storage chamber at the top of described concentration cylinder
Pipe and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, on described swingle
Being provided with scraper dish, the web of described scraper dish contacts, on the roof of described concentration cylinder with the inwall concentrating cylinder
Being provided with lift cylinder, the top of described swingle is connected through roof and the top of described concentration cylinder with described lift cylinder
Connecing, be provided with electric rotating machine in described swingle, the main shaft of described electric rotating machine is connected with the center of described scraper dish,
The top of described concentration cylinder is additionally provided with the elevating lever through roof, is provided with horn-like suction in the bottom of described elevating lever and steeps mouth,
It is provided with in described elevating lever and steeps, with described horn-like suction, the suction bubble passage that mouth is connected, be provided with suction at the top of described elevating lever
The attached pump housing, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, and described elevating lever is in described regulation
In described concentration cylinder, lifting moving is done under the effect of cylinder.
Described invigorating spleen prescription compositions, the sidewall concentrating cylinder in said extracted method described in enrichment facility is provided with observation
Window, is provided with seal glass in described observation window, and described scraper dish is circular, the external diameter of described scraper dish and concentration cylinder
Identical and scraper dish the inner ring surface of the internal diameter of body is connected with the main shaft of electric rotating machine by dowel bar, and described vaporizer is
Columnar structured, described vaporizer is connected to concentrate the diapire of cylinder by adpting flange, is provided with evaporation in described vaporizer
Pipe, is provided with the steam inlet being connected with described evaporation tube and steam (vapor) outlet on the sidewall of described vaporizer.
Described invigorating spleen prescription compositions, is dried in said extracted method and uses device, including hothouse and described hothouse
The air quantity conditioning chamber being connected, is provided with charging aperture on the roof of described hothouse, is provided with discharging in the bottom of described hothouse
Mouthful, described air quantity conditioning chamber is provided with air intake passage, described hothouse is provided with air exhaust passage, it is characterised in that: in institute
State and be provided with dividing plate between air quantity conditioning chamber and described hothouse, described dividing plate is uniformly provided with pore, on described dividing plate also
Being provided with the cavity of lateral opening, described cavity is arranged on the side by hothouse, is provided with electric rotating machine, also sets in described cavity
There is the swingle being connected with described electric rotating machine main shaft, be provided with upset paddle, described rotation on the surface of described swingle
Bar stretches in described hothouse, is provided with air guide channel at the center of described swingle, is uniformly provided with on described upset paddle
The hot gas injection jets being connected with described air guide channel, when described wind is stretched in the end of described swingle in conditioning chamber, leads described
It is provided with heat conduction blower fan in gas passage, is provided with movable plate when described wind in conditioning chamber, be provided with and institute in the side of described movable plate
State the air quantity adjusting plug that pore matches and the air holes being arranged between adjacent air quantity adjusting plug, at described movable plate and described wind
Mobile regulation cylinder it is provided with between the sidewall of amount conditioning chamber.
Described invigorating spleen prescription compositions, is dried in said extracted method and uses the roof of described air quantity conditioning chamber described in device
Being provided with chute, the diapire at described air quantity conditioning chamber is provided with shifting chute, and described shifting chute is consistent with the trend of described chute, described
The top of movable plate is movably arranged in described chute by scroll wheel, and the bottom of described movable plate is arranged by movable block activity
In described shifting chute, described mobile regulation cylinder is arranged between described movable block and the end wall of shifting chute.
Described invigorating spleen prescription compositions, is dried in said extracted method and uses the main shaft of electric rotating machine described in device to be provided with
Driving fluted disc, be provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, the opening part of described cavity is provided with anti-
Protecting wire net, described swingle is arranged through described protection network.
The application in preparation treatment Gastric Ulcer Treatment of the described invigorating spleen prescription compositions.
In prior art, the original extracting method of Chinese medicine, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, no
Conveniently taking, ligustrazine content prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation are just
Victory, it not only can start scraper dish as required and do lift adjustment as required such that it is able to realize concentrating cylinder
Inwall carries out scraping dirt process, and the descending operation that simultaneously can also regulate elevating lever as required makes horn-like bubble mouth of inhaling be in medicine
Being absorbed by the foam on surface by the absorption pump housing just above of liquid level, solves tube wall medicine dirt in conventional art medicine enrichment facility
Removing the technical deficiency of difficulty, stability in use is good and the suitability is strong.This drying equipment structure is simple, simple operation, is provided with and turns over
Turning paddle and be provided with, in upset paddle, the hot gas injection jets being connected with air quantity conditioning chamber, it is right to make while stirring medical material
Medical material is dried, and adds the speed contacted with medical material, can effectively improve medicinal material drying efficiency, and stability in use
Good, solve the technical deficiency that conventional art pharmaceutical drying device drying efficiency is low, the suitability is strong and practicality good.The leaves of pulse plants in the present invention
Perfume, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Amomi invigorating the spleen for eliminating dampness are monarch drug, Rhizoma Chuanxiong, Herba Eupatorii, Rhizoma Zingiberis, Rhizoma Cyperi, Rhizoma Corydalis, the Radix Aucklandiae, invigorating blood circulation of Caulis Perillae
The stasis of blood, regulating the flow of vital energy as ministerial drug, Poria, the Radix Linderae, Radix Puerariae, Semen Coicis dampness removing reduce phlegm as adjuvant, full side compatibility, bring out the best in each other, have strong
Spleen effect.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Take Herba Pogostemonis 10g, Ramulus Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Fructus Amomi 6g, Rhizoma Chuanxiong 6g, Herba Eupatorii 10g, Rhizoma Zingiberis 3g, Rhizoma Cyperi
10g, Rhizoma Corydalis 10g, Radix Aucklandiae 10g, Caulis Perillae 10g, Poria 10g, Radix Linderae 10g, Radix Puerariae 10g, Semen Coicis 10g, add 10 times of weight of medical material
Water, soak 0.5h, decocts 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, conjunction
And twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs,
Standing, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction,
Obtain supercritical extract, continue to concentrate, concentrated solution is dried, is prepared as invigorating spleen prescription compositions, dosage form by conventional method
For tablet.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 4% that entrainer accounts for the percent by volume of total extractant, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/
G crude drug min, extraction time 150min, obtain supercritical extract.
See that Fig. 1: described invigorating spleen prescription compositions, above-mentioned twice concentration use device, including concentrating cylinder 1, be arranged on institute
State the vaporizer 2 concentrated bottom cylinder 1, be provided with venthole 3 at the top of described concentration cylinder 1 and condense panel 4, described solidifying
It is provided with cooling liquid storage chamber 5 in junction plate 4, is provided with at the top of described concentration cylinder 1 and is connected with described cooling liquid storage chamber 5
Feed tube 6 and discharge pipe 7, be provided with condensation panel, the gas partial coagulation of evaporation at medicine night can be become moisture, be possible to prevent medicine
Thing vapors away, and the roof in described concentration cylinder 1 is provided with the swingle 8 downwardly extended, and described swingle 8 is provided with scraper
Dish 9, the web of described scraper dish 9 contacts with the inwall concentrating cylinder 1, is provided with liter on the roof of described concentration cylinder 1
Sending down the abnormal ascending QI cylinder 10, the top of described swingle 8 is connected through roof and the top of described concentration cylinder 1 with described lift cylinder 10
Connect, in described swingle 8, be provided with electric rotating machine 11, the center phase of the main shaft of described electric rotating machine 11 and described scraper dish 9
Connect, be additionally provided with the elevating lever 12 through roof at the top of described concentration cylinder 1, be provided with loudspeaker in the bottom of described elevating lever 12
Shape inhales bubble mouth 13, is provided with and steeps the suction bubble passage 14 that mouth 13 is connected, in institute with described horn-like suction in described elevating lever 12
The top stating elevating lever 12 is provided with the absorption pump housing 15, is provided with tune between the roof and described elevating lever 12 of described concentration cylinder 1
Displacements of cylinders 16, described elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
The sidewall of described concentration cylinder 1 is provided with observation window 17, in described observation window, is provided with seal glass 18.
Described scraper dish is circular, the external diameter of described scraper dish with concentrate cylinder internal diameter is identical and scraper dish
Inner ring surface be connected with the main shaft of electric rotating machine by dowel bar.It is not to carry out owing to scraping dirt and inhaling bubble simultaneously, so
Both can't cause mutually restriction.
Described vaporizer 2 is columnar structured, and described vaporizer 2 is connected to concentrate the end of cylinder 1 by adpting flange 19
Wall, is provided with evaporation tube 20 in described vaporizer, is provided with and is connected with described evaporation tube 20 on the sidewall of described vaporizer 2
Steam inlet 21 and steam (vapor) outlet 22.
Seeing Fig. 2: described invigorating spleen prescription compositions, above-mentioned dry use device, including including hothouse 1 and described being dried
The air quantity conditioning chamber 2 that room 1 is connected, is provided with charging aperture 3 on the roof of described hothouse 1, sets in the bottom of described hothouse 1
There is discharging opening 4, described air quantity conditioning chamber 2 is provided with air intake passage 5, described hothouse 1 is provided with air exhaust passage 6, in institute
State and between air quantity conditioning chamber 2 and described hothouse 1, be provided with dividing plate 7, described dividing plate 7 is uniformly provided with pore 8, at described dividing plate
Being additionally provided with the cavity 9 of lateral opening on 7, described cavity 9 is arranged on the side by hothouse 1, is provided with rotation in described cavity 9
Motor 10, is additionally provided with the swingle 11 being connected with described electric rotating machine 10 main shaft, is provided with on the surface of described swingle 11 and turns over
Turning paddle 12, described swingle 11 stretches in described hothouse 1, is provided with air guide channel 13 at the center of described swingle 11,
Described upset paddle 12 is uniformly provided with the hot gas injection jets 14 being connected with described air guide channel 13, described swingle 11
When described wind is stretched in end in conditioning chamber 2, in described air guide channel 13, it is provided with heat conduction blower fan 15, the conditioning chamber 2 when described wind
Inside it is provided with movable plate 16, is provided with the air quantity adjusting plug 17 matched with described pore 8 in the side of described movable plate 16 and arranges
Air holes 18 between adjacent air quantity adjusting plug, is provided with shifting between the sidewall of described movable plate 16 and described air quantity conditioning chamber 2
Dynamic regulation cylinder 19.
Roof at described air quantity conditioning chamber 2 is provided with chute 20, and the diapire at described air quantity conditioning chamber 2 is provided with shifting chute
21, described shifting chute 21 is consistent with the trend of described chute 20, and the top of described movable plate 16 is arranged by scroll wheel 22 is movable
In described chute 20, the bottom of described movable plate 16 is movably arranged in described shifting chute 21 by movable block 23, described shifting
Dynamic regulation cylinder 19 is arranged between described movable block 23 and the end wall of shifting chute 21.
The main shaft of described electric rotating machine is provided with driving fluted disc 24, described swingle is provided with and described driving fluted disc
Mutually ratcheting teeth groove 25.
Opening part at described cavity is provided with protection network 26, and described swingle is arranged through described protection network.
Embodiment 2
Take Herba Pogostemonis 10g, Ramulus Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Fructus Amomi 6g, Rhizoma Chuanxiong 6g, Herba Eupatorii 10g, Rhizoma Zingiberis 3g, Rhizoma Cyperi
10g, Rhizoma Corydalis 10g, Radix Aucklandiae 10g, Caulis Perillae 10g, Poria 10g, Radix Linderae 10g, Radix Puerariae 10g, Semen Coicis 10g, add 10 times of weight of medical material
Water, soak 0.5h, decocts 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, conjunction
And twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs,
Standing, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction,
Obtain supercritical extract, continue to concentrate, concentrated solution is dried, is prepared as invigorating spleen prescription compositions, dosage form by conventional method
For tablet.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/
G crude drug min, extraction time 180min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Embodiment 3
Take Herba Pogostemonis 10g, Ramulus Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Fructus Amomi 6g, Rhizoma Chuanxiong 6g, Herba Eupatorii 10g, Rhizoma Zingiberis 3g, Rhizoma Cyperi
10g, Rhizoma Corydalis 10g, Radix Aucklandiae 10g, Caulis Perillae 10g, Poria 10g, Radix Linderae 10g, Radix Puerariae 10g, Semen Coicis 10g, add 10 times of weight of medical material
Water, soak 0.5h, decocts 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, conjunction
And twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs,
Standing, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical extraction,
Obtain supercritical extract, continue to concentrate, concentrated solution is dried, is prepared as invigorating spleen prescription compositions, dosage form by conventional method
For tablet.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 5% that entrainer accounts for the percent by volume of total extractant, extracting pressure 20MPa of described CO2 supercritical extraction,
Temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Above-described embodiment Chinese crude drug all meets standards of pharmacopoeia.
Embodiment 4: ligustrazine assay experimentation data in invigorating spleen prescription compositions of the present invention
1.1 Experimental agents: invigorating spleen prescription compositions of the present invention: prepare by embodiment 1-3 method.Reference implementation in matched group
Example 1 uses common concentration to be prepared as tablet with drying means.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters 2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column be Shim-Pack C18 (4.6mm ×
250mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability:
Chromatographic column: Shim-Pack C18 (4.6mm × 250mm, 5 μm)；Flowing phase: methanol-1% glacial acetic acid solution (35:65), detection
Wavelength 300nm；Column temperature 40 DEG C；Sample size 10 μ l.Number of theoretical plate is calculated by ligustrazine peak should be not less than 2000.Take ligustrazine comparison
Product are appropriate, accurately weighed, add methanol and make every lm l solution containing 5ug, to obtain final product.The preparation of need testing solution takes content uniformity item
Under this product, finely ground, take about 0.5g, accurately weighed, put in 25ml measuring bottle, add methanol 20ml, supersound process (power 250W, frequently
Rate 40kHz) 30 minutes, let cool, add methanol to scale, shake up, filter, take subsequent filtrate, to obtain final product.Precision absorption reference substance is molten respectively
Liquid injects chromatograph of liquid with each 20ul of need testing solution, measures, to obtain final product.
1.4 experimental result
Ligustrazine assay result in invigorating spleen prescription compositions prepared by each embodiment
| Sample source | Ligustrazine content (%) |
| Embodiment 1 | 1.8 |
| Embodiment 2 | 1.4 |
| Embodiment 3 | 1.6 |
| Matched group | 0.3 |
According to the result of the test of upper table, in invigorating spleen prescription compositions prepared by embodiment of the present invention 1-3, ligustrazine contains
Amount is apparently higher than matched group.
Embodiment 5: clinical observation
Physical data: select the patients w ith peptic ulcer disease 150 example clinical observation made a definite diagnosis, be randomly divided into treatment group and matched group two
Group, wherein treatment group 100 example, wherein male 60 example, women 40 example, age 30-65 year, 52.5 years old mean age, the course of disease 1
-6 years moons, average 2.6 years.Matched group 50 example, wherein male 31 example, women 19 example, age 29-63 year, 49.6 years old mean age,
The course of disease 2 months-6 years, average 3.0 years.The course of disease of two groups of cases, degrees of symptoms are basically identical, and without significant difference, having can
Compare property.
Medicament selection: treatment group: take the tablet of the embodiment of the present invention 1 preparation, oral, three times a day, each 4, after meal
Warm water delivery service；Within 14 days, it is 1 course for the treatment of, takes medicine continuously 2 courses for the treatment of.
Matched group: take Cimitidine Tablets, oral, three times a day, and each 1, warm water delivery service after meal；Take medicine 4 continuously
Week.
Curative effect determinate standard: (1) cure: gastral cavilty twinge, abdominal distention, belch, feel sick etc. symptom all disappear, physical function is extensive
Multiple normal.(2 take a turn for the better: above-mentioned symptom has alleviated, and physical function makes moderate progress.(3 is invalid: by symptom after treatment without the best
Turn.
Result: treatment group: cure 64 examples, take a turn for the better 28 examples, invalid 8 examples, cure rate 64%, total effective rate 92%, matched group:
Curing 20 examples, take a turn for the better 15 examples, invalid 15 examples, cure rate 40%, total effective rate 70%.
After drug withdrawal half a year, paying a return visit all healing patients, treatment composition merit pays a return visit 64 examples, and no case was recurrence.Comparison
Composition merit pays a return visit 25 examples, has 7 example recurrences, and relapse rate is 28%.The pharmaceutical composition that the visible present invention treats gastric ulcer is the most excellent
In existing Western medicine, there is function of invigorating spleen.
Claims (8)
1. an invigorating spleen prescription compositions, it is characterised in that preparation method is: take Herba Pogostemonis 10g, Ramulus Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, the Radix Paeoniae Alba
15g, Fructus Amomi 6g, Rhizoma Chuanxiong 6g, Herba Eupatorii 10g, Rhizoma Zingiberis 3g, Rhizoma Cyperi 10g, Rhizoma Corydalis 10g, Radix Aucklandiae 10g, Caulis Perillae 10g, Poria 10g, the Radix Linderae
10g, Radix Puerariae 10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add medicine
The water of 8 times of weight of material, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds second
Alcohol makes the percent by volume of alcohol content reach 75%, stirs, and stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and
Reclaim ethanol, obtain concentrated solution, use supercritical extraction, obtain supercritical extract, continue to concentrate, concentrated solution is dried, use
Conventional method is prepared as invigorating spleen prescription compositions.
Invigorating spleen prescription compositions the most according to claim 1, it is characterised in that in preparation method, water extract-alcohol precipitation concentrated solution is added
Enter to CO2In supercritical extraction device, ethanol is as entrainer, and it is 4-6% that entrainer accounts for the percent by volume of total extractant, extraction
Pressure power 15-30MPa, temperature 30-50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, must surpass and face
Boundary's extract, optimum condition is: described CO2It is 5% that supercritical extraction entrainer accounts for the percent by volume of total extractant, described
CO2Extracting pressure 20MPa of supercritical extraction, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
Invigorating spleen prescription compositions the most according to claim 1, it is characterised in that concentrate in said extracted method and use device, bag
Include concentration cylinder, be arranged on the vaporizer of described concentration cylinder body bottom, be provided with venthole at the top of described concentration cylinder and coagulate
Junction plate, is provided with cooling liquid storage chamber in described condensation panel, is provided with and described cooling liquid at the top of described concentration cylinder
The storage feed tube that is connected of chamber and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with and downwardly extends
Swingle, described swingle is provided with scraper dish, and the web of described scraper dish contacts, in institute with the inwall concentrating cylinder
State and concentrate the roof of cylinder and be provided with lift cylinder, the top of described swingle through the roof of described concentration cylinder and top with
Described lift cylinder is connected, and is provided with electric rotating machine, the main shaft of described electric rotating machine and described scraper in described swingle
The center of dish is connected, and is additionally provided with the elevating lever through roof at the top of described concentration cylinder, in the bottom of described elevating lever
It is provided with horn-like suction and steeps mouth, be provided with in described elevating lever and steep the suction bubble passage that mouth is connected, described with described horn-like suction
The top of elevating lever is provided with the absorption pump housing, is provided with regulation cylinder, institute between the roof and described elevating lever of described concentration cylinder
State elevating lever and in described concentration cylinder, do lifting moving under the effect of described regulation cylinder.
Invigorating spleen prescription compositions the most according to claim 3, it is characterised in that dense described in enrichment facility in said extracted method
The sidewall of contracting cylinder is provided with observation window, is provided with seal glass in described observation window, and described scraper dish is circular, described
Identical with the internal diameter concentrating cylinder and scraper dish the inner ring surface of the external diameter of scraper dish passes through dowel bar and electric rotating machine
Main shaft is connected, and described vaporizer is columnar structured, and described vaporizer is connected to concentrate the diapire of cylinder by adpting flange,
In described vaporizer, it is provided with evaporation tube, the sidewall of described vaporizer is provided with the steam inlet being connected with described evaporation tube
And steam (vapor) outlet.
Invigorating spleen prescription compositions the most according to claim 1, it is characterised in that be dried in said extracted method and use device, bag
Include the air quantity conditioning chamber that hothouse is connected with described hothouse, the roof of described hothouse is provided with charging aperture, described
The bottom of hothouse is provided with discharging opening, is provided with air intake passage, is provided with air draft on described hothouse on described air quantity conditioning chamber
Passage, it is characterised in that: between described air quantity conditioning chamber and described hothouse, it is provided with dividing plate, described dividing plate is uniformly provided with
Pore, is additionally provided with the cavity of lateral opening on described dividing plate, and described cavity is arranged on the side by hothouse, at described cavity
Inside it is provided with electric rotating machine, is additionally provided with the swingle being connected with described electric rotating machine main shaft, is provided with on the surface of described swingle
Upset paddle, described swingle stretches in described hothouse, is provided with air guide channel at the center of described swingle, turns over described
Turn and on paddle, be uniformly provided with the hot gas injection jets being connected with described air guide channel, when described wind is stretched in the end of described swingle
In conditioning chamber, in described air guide channel, it is provided with heat conduction blower fan, is provided with movable plate when described wind in conditioning chamber, in described movement
The side of plate is provided with described pore matches air quantity adjusting plug and the air holes being arranged between adjacent air quantity adjusting plug, in institute
State and between the sidewall of movable plate and described air quantity conditioning chamber, be provided with mobile regulation cylinder.
Invigorating spleen prescription compositions the most according to claim 5, it is characterised in that be dried in said extracted method and use device institute
The roof stating described air quantity conditioning chamber is provided with chute, and the diapire at described air quantity conditioning chamber is provided with shifting chute, described shifting chute with
The trend of described chute is consistent, and the top of described movable plate is movably arranged in described chute by scroll wheel, described movable plate
Bottom be movably arranged in described shifting chute by movable block, described mobile regulation cylinder is arranged on described movable block and movement
Between the end wall of groove.
Invigorating spleen prescription compositions the most according to claim 5, it is characterised in that be dried in said extracted method and use device institute
The main shaft stating electric rotating machine is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle,
The opening part of described cavity is provided with protection network, and described swingle is arranged through described protection network.
Invigorating spleen prescription compositions application in preparation treatment Gastric Ulcer Treatment the most according to claim 1.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078046A (en) * | 2018-10-12 | 2018-12-25 | 广州医科大学 | A kind of supercritical CO2The method for extracting volatile oil in the dizzy soup in town |
| CN109966429A (en) * | 2019-04-30 | 2019-07-05 | 福州帅宝生物科技有限公司 | A kind of Semen Coicis extract with hepatoprotective effect |
| CN110639232A (en) * | 2019-11-12 | 2020-01-03 | 湖南刘文龙生物医药有限责任公司 | Biological medicine extraction element |
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| CN104208563A (en) * | 2014-09-22 | 2014-12-17 | 刘瑞云 | Medicine for treating gastritis |
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| CN104208563A (en) * | 2014-09-22 | 2014-12-17 | 刘瑞云 | Medicine for treating gastritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078046A (en) * | 2018-10-12 | 2018-12-25 | 广州医科大学 | A kind of supercritical CO2The method for extracting volatile oil in the dizzy soup in town |
| CN109966429A (en) * | 2019-04-30 | 2019-07-05 | 福州帅宝生物科技有限公司 | A kind of Semen Coicis extract with hepatoprotective effect |
| CN110639232A (en) * | 2019-11-12 | 2020-01-03 | 湖南刘文龙生物医药有限责任公司 | Biological medicine extraction element |
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