CN106110066A - A kind of collyrium - Google Patents

A kind of collyrium Download PDF

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Publication number
CN106110066A
CN106110066A CN201610617654.8A CN201610617654A CN106110066A CN 106110066 A CN106110066 A CN 106110066A CN 201610617654 A CN201610617654 A CN 201610617654A CN 106110066 A CN106110066 A CN 106110066A
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China
Prior art keywords
cylinder
collyrium
radix
swingle
roof
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CN201610617654.8A
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Chinese (zh)
Inventor
卞毓平
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Priority to CN201610617654.8A priority Critical patent/CN106110066A/en
Publication of CN106110066A publication Critical patent/CN106110066A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

nullThe present invention provides a kind of collyrium，Take Fructus Lycii 10g、Arillus Longan 10g、Fructus Schisandrae Chinensis 10g、Semen Plantaginis 15g、Poria cum Radix Pini 6g、Radix Polygalae 6g、Radix Ophiopogonis 10g、Rhizoma Polygonati Odorati 3g、Radix Angelicae Sinensis 30g、Radix Bupleuri 10g、Folium Mori 10g、Caulis Perillae 10g、Poria 10g、Exocarpium Benincasae 10g、Radix Puerariae 10g、Semen Coicis 10g，Add the water of 10 times of weight of medical material，Soak 0.5h，Decoct 1 hour，Filter，Medicinal residues add the water of 8 times of weight of medical material，Decoct 1 hour，Medicinal liquid leaches，Merge twice decoction liquor，Being concentrated into 60 DEG C of relative densities is 1.05，Adding ethanol makes the percent by volume of alcohol content reach 75%，Stirring，Stand，Filter，When filtrate is concentrated into 65 DEG C, relative density is 1.25，And reclaim ethanol，Obtain concentrated solution，Use supercritical extraction，Obtain supercritical extract，Continue to concentrate，Concentrated solution is dried,It is prepared as collyrium by conventional method，Prepare ferulaic acid content high.

Description

A kind of collyrium
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of collyrium.
Background technology
Traditional Chinese medicine extraction method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient to use Measure excessive, it has not been convenient to take, had a strong impact on this product and applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of collyrium.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of collyrium, preparation method is: take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weights of medical material The water of amount, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes to contain The percent by volume of alcohol amount reaches 75%, and stirring, standing, filtration, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims second Alcohol, obtains concentrated solution, uses supercritical extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, uses routine side Method is prepared as collyrium.
Described collyrium, joins CO by water extract-alcohol precipitation concentrated solution in preparation method2In supercritical extraction device, ethanol conduct Entrainer, it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO2 Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, and optimum condition is: described CO2Surpass and face It is 5% that boundary's extraction entrainer accounts for the percent by volume of total extractant, described CO2Extracting pressure 20MPa of supercritical extraction, temperature Spend 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
Described collyrium, in said extracted method, twice concentration uses device, including concentrating cylinder, is arranged on described concentration The vaporizer of cylinder body bottom, is provided with venthole and condenses panel, setting in described condensation panel at the top of described concentration cylinder There is cooling liquid storage chamber, be provided with the feed tube and discharge being connected with described cooling liquid storage chamber at the top of described concentration cylinder Pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, and described swingle is provided with scrapes dirt Cutterhead, the web of described scraper dish contacts with the inwall concentrating cylinder, is provided with lifting on the roof of described concentration cylinder Cylinder, the top of described swingle is connected with described lift cylinder, described through roof and the top of described concentration cylinder Being provided with electric rotating machine in swingle, the main shaft of described electric rotating machine is connected with the center of described scraper dish, in described concentration The top of cylinder is additionally provided with the elevating lever through roof, is provided with horn-like suction in the bottom of described elevating lever and steeps mouth, at described liter It is provided with in fall bar and steeps, with described horn-like suction, the suction bubble passage that mouth is connected, be provided with the absorption pump housing at the top of described elevating lever, Being provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, described elevating lever is at the work of described regulation cylinder In described concentration cylinder, lifting moving is done under with.
Described collyrium, the sidewall concentrating cylinder in said extracted method described in enrichment facility is provided with observation window, in institute Being provided with seal glass in stating observation window, described scraper dish is circular, and the external diameter of described scraper dish is interior with concentration cylinder Identical and scraper dish the inner ring surface in footpath is connected with the main shaft of electric rotating machine by dowel bar, and described vaporizer is cylindrical shape Structure, described vaporizer is connected to concentrate the diapire of cylinder, is provided with evaporation tube, in institute in described vaporizer by adpting flange The sidewall stating vaporizer is provided with the steam inlet and steam (vapor) outlet being connected with described evaporation tube.
Described collyrium, is dried in said extracted method and uses device, be connected with described hothouse including hothouse Air quantity conditioning chamber, is provided with charging aperture on the roof of described hothouse, is provided with discharging opening in the bottom of described hothouse, described Air quantity conditioning chamber is provided with air intake passage, is provided with air exhaust passage on described hothouse, it is characterised in that: regulate at described air quantity It is provided with dividing plate between room and described hothouse, described dividing plate is uniformly provided with pore, described dividing plate is additionally provided with side opening The cavity of mouth, described cavity is arranged on the side by hothouse, is provided with electric rotating machine in described cavity, is additionally provided with and described rotation The swingle that rotating motor main shaft is connected, is provided with upset paddle on the surface of described swingle, and described swingle stretches into described In hothouse, it is provided with air guide channel at the center of described swingle, described upset paddle is uniformly provided with and described inducing QI The hot gas injection jets that passage is connected, when described wind is stretched in the end of described swingle in conditioning chamber, sets in described air guide channel There is heat conduction blower fan, be provided with movable plate when described wind in conditioning chamber, be provided with in the side of described movable plate and match with described pore The air quantity adjusting plug closed and the air holes being arranged between adjacent air quantity adjusting plug, at described movable plate and described air quantity conditioning chamber Mobile regulation cylinder it is provided with between sidewall.
Described collyrium, is dried in said extracted method and uses the roof of described air quantity conditioning chamber described in device to be provided with cunning Groove, the diapire at described air quantity conditioning chamber is provided with shifting chute, and described shifting chute is consistent with the trend of described chute, described movable plate Top be movably arranged in described chute by scroll wheel, the bottom of described movable plate is movably arranged on described by movable block In shifting chute, described mobile regulation cylinder is arranged between described movable block and the end wall of shifting chute.
Described collyrium, is dried in said extracted method and uses the main shaft of electric rotating machine described in device to be provided with driving tooth Dish, is provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, and the opening part of described cavity is provided with protection network, institute State swingle to arrange through described protection network.
The application in preparation treatment medicine for treating myopia of the described collyrium.
In prior art, the original extracting method of Chinese medicine, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, no Conveniently taking, ferulaic acid content prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation are just Victory, it not only can start scraper dish as required and do lift adjustment as required such that it is able to realize concentrating cylinder Inwall carries out scraping dirt process, and the descending operation that simultaneously can also regulate elevating lever as required makes horn-like bubble mouth of inhaling be in medicine Being absorbed by the foam on surface by the absorption pump housing just above of liquid level, solves tube wall medicine dirt in conventional art medicine enrichment facility Removing the technical deficiency of difficulty, stability in use is good and the suitability is strong.This drying equipment structure is simple, simple operation, is provided with and turns over Turning paddle and be provided with, in upset paddle, the hot gas injection jets being connected with air quantity conditioning chamber, it is right to make while stirring medical material Medical material is dried, and adds the speed contacted with medical material, can effectively improve medicinal material drying efficiency, and stability in use Good, solve the technical deficiency that conventional art pharmaceutical drying device drying efficiency is low, the suitability is strong and practicality good.Chinese holly in the present invention Qi, Arillus Longan, Fructus Schisandrae Chinensis, Semen Plantaginis, Poria cum Radix Pini's liver heat removing and eyesight improving are monarch drug, and Radix Polygalae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Bupleuri, Folium Mori are invigorated blood circulation Blood stasis dispelling, regulating the flow of vital energy as ministerial drug, Caulis Perillae, Poria, Exocarpium Benincasae, Radix Puerariae, Semen Coicis dampness removing reduce phlegm as adjuvant, full side compatibility, benefit mutually Evident, there is treatment myopia function.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal Belong to the scope of the present invention.
Embodiment 1
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10 The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct Entrainer, it is 4% that entrainer accounts for the percent by volume of total extractant, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/ G crude drug min, extraction time 150min, obtain supercritical extract.
See that Fig. 1: described collyrium, above-mentioned twice concentration use device, including concentrating cylinder 1, be arranged on described concentration cylinder Vaporizer 2 bottom body 1, is provided with venthole 3 and condenses panel 4, at described condensation panel 4 at the top of described concentration cylinder 1 Inside it is provided with cooling liquid storage chamber 5, is provided with the feed liquor being connected with described cooling liquid storage chamber 5 at the top of described concentration cylinder 1 Pipe 6 and discharge pipe 7, be provided with condensation panel, the gas partial coagulation of medicine evaporation at night can be become moisture, be possible to prevent drug volatilization Falling, the roof in described concentration cylinder 1 is provided with the swingle 8 downwardly extended, and described swingle 8 is provided with scraper dish 9, institute The web stating scraper dish 9 contacts with the inwall concentrating cylinder 1, is provided with lift cylinder on the roof of described concentration cylinder 1 10, the top of described swingle 8 is connected with described lift cylinder 10, in institute through roof and the top of described concentration cylinder 1 Being provided with electric rotating machine 11 in stating swingle 8, the main shaft of described electric rotating machine 11 is connected with the center of described scraper dish 9, The top of described concentration cylinder 1 is additionally provided with the elevating lever 12 through roof, is provided with horn-like suction in the bottom of described elevating lever 12 Bubble mouth 13, is provided with in described elevating lever 12 and steeps the suction bubble passage 14 that mouth 13 is connected, in described lifting with described horn-like suction The top of bar 12 is provided with the absorption pump housing 15, is provided with regulation cylinder between the roof and described elevating lever 12 of described concentration cylinder 1 16, described elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
The sidewall of described concentration cylinder 1 is provided with observation window 17, in described observation window, is provided with seal glass 18.
Described scraper dish is circular, the external diameter of described scraper dish with concentrate cylinder internal diameter is identical and scraper dish Inner ring surface be connected with the main shaft of electric rotating machine by dowel bar.It is not to carry out owing to scraping dirt and inhaling bubble simultaneously, so Both can't cause mutually restriction.
Described vaporizer 2 is columnar structured, and described vaporizer 2 is connected to concentrate the end of cylinder 1 by adpting flange 19 Wall, is provided with evaporation tube 20 in described vaporizer, is provided with and is connected with described evaporation tube 20 on the sidewall of described vaporizer 2 Steam inlet 21 and steam (vapor) outlet 22.
Seeing Fig. 2: described collyrium, above-mentioned dry use device, including including that hothouse 1 is connected with described hothouse 1 Air quantity conditioning chamber 2, the roof of described hothouse 1 is provided with charging aperture 3, is provided with discharging opening in the bottom of described hothouse 1 4, described air quantity conditioning chamber 2 is provided with air intake passage 5, described hothouse 1 is provided with air exhaust passage 6, adjusts at described air quantity It is provided with dividing plate 7 between joint room 2 and described hothouse 1, described dividing plate 7 is uniformly provided with pore 8, described dividing plate 7 also sets There are the cavity 9 of lateral opening, described cavity 9 to be arranged on the side by hothouse 1, in described cavity 9, are provided with electric rotating machine 10, It is additionally provided with the swingle 11 being connected with described electric rotating machine 10 main shaft, is provided with upset paddle on the surface of described swingle 11 12, described swingle 11 stretches in described hothouse 1, is provided with air guide channel 13 at the center of described swingle 11, turns over described Turning and be uniformly provided with the hot gas injection jets 14 being connected with described air guide channel 13 on paddle 12, the end of described swingle 11 is stretched into During described wind in conditioning chamber 2, in described air guide channel 13, it is provided with heat conduction blower fan 15, is provided with shifting when described wind in conditioning chamber 2 Dynamic plate 16, is provided with, in the side of described movable plate 16, the air quantity adjusting plug 17 matched with described pore 8 and is arranged on adjacent wind Air holes 18 between amount adjusting plug, is provided with mobile regulation gas between the sidewall of described movable plate 16 and described air quantity conditioning chamber 2 Cylinder 19.
Roof at described air quantity conditioning chamber 2 is provided with chute 20, and the diapire at described air quantity conditioning chamber 2 is provided with shifting chute 21, described shifting chute 21 is consistent with the trend of described chute 20, and the top of described movable plate 16 is arranged by scroll wheel 22 is movable In described chute 20, the bottom of described movable plate 16 is movably arranged in described shifting chute 21 by movable block 23, described shifting Dynamic regulation cylinder 19 is arranged between described movable block 23 and the end wall of shifting chute 21.
The main shaft of described electric rotating machine is provided with driving fluted disc 24, described swingle is provided with and described driving fluted disc Mutually ratcheting teeth groove 25.
Opening part at described cavity is provided with protection network 26, and described swingle is arranged through described protection network.
Embodiment 2
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10 The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct Entrainer, it is 6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/ G crude drug min, extraction time 180min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Embodiment 3
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10 The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct Entrainer, it is 5% that entrainer accounts for the percent by volume of total extractant, extracting pressure 20MPa of described CO2 supercritical extraction, Temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Above-described embodiment Chinese crude drug all meets standards of pharmacopoeia.
Embodiment 4: ferulaic acid content determination experiment research data in collyrium of the present invention
1.1 Experimental agents: collyrium of the present invention: prepare by embodiment 1-3 method.Matched group is that reference example 1 uses Common concentration is prepared as tablet with drying means.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump； Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column be Shim-Pack C18 (4.6mm × 250mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability: Chromatographic column: Shim-Pack C18 (4.6mm × 250mm, 5 μm)；Flowing phase: methanol-1% glacial acetic acid solution (35:65), detection Wavelength 300nm；Column temperature 40 DEG C；Sample size 10 μ l.Number of theoretical plate is calculated by ferulic acid peak should be not less than 2000.Take ferulic acid comparison Product are appropriate, accurately weighed, add methanol and make every lml solution containing 5ug, to obtain final product.The preparation of need testing solution takes content uniformity item Under this product, finely ground, take about 0.5g, accurately weighed, put in 25ml measuring bottle, add methanol 20ml, supersound process (power 250W, frequently Rate 40kHz) 30 minutes, let cool, add methanol to scale, shake up, filter, take subsequent filtrate, to obtain final product.Precision absorption reference substance is molten respectively Liquid injects chromatograph of liquid with each 20ul of need testing solution, measures, to obtain final product.
1.4 experimental result
Ferulaic acid content measurement result in collyrium prepared by each embodiment
Sample source Ferulaic acid content (%)
Embodiment 1 1.9
Embodiment 2 1.7
Embodiment 3 1.8
Matched group 0.2
According to the result of the test of upper table, in collyrium prepared by embodiment of the present invention 1-3, ferulaic acid content is the highest In matched group.
Embodiment 5: clinical observation
Physical data: the present invention is light to 100 examples, medium myopia patient carries out clinical observation treatment, wherein age reckling 10 years old, the maximum 35 years old, 18 years old mean age；Man's 58 examples, female 42 example.Get rid of the caused myopia of heredity.Wherein low myopia is 300 Within degree；Medium myopia is 300-600 degree, and cardinal symptom is for seeing that distant objects is smudgy.
Therapeutic Method: random packet, gives respectively and the collyrium of the embodiment of the present invention 1 preparation, drips three every day, and each 2 Drip.10 days 1 courses for the treatment of, altogether three courses for the treatment of of treatment.Avoid pungent during taking medicine.Eye exercises are done 5-10 minute after taking medicine every day 1 hour Better.
Efficacy assessment standard: cure: see that remote thing is smudgy and wait Clinical symptom and sign to disappear, vision restoration to more than 1.0. Effective: seeing that remote thing is smudgy and wait Clinical symptom and sign basic or the disappearance of big portion, vision is not up to 1.0, but improves more than 0.2. Effective: seeing that the clinical symptoms such as remote thing is smudgy are clearly better or take a turn for the better, vision is not up to 1.0, increases, but improves and exist Less than 0.2.Invalid: Clinical symptom and sign is without improving, and Index for examination has no improvement.
Therapeutic effect:
Illustrate that effect of the present invention significantly improves.

Claims (8)

1. a collyrium, it is characterised in that preparation method is: take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Fructus Benincasae Skin 10g, Radix Puerariae 10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add The water of 8 times of weight of medical material, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds Ethanol makes the percent by volume of alcohol content reach 75%, stirs, and stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, And reclaim ethanol, obtain concentrated solution, use supercritical extraction, obtain supercritical extract, continue to concentrate, concentrated solution is dried, It is prepared as collyrium by conventional method.
Collyrium the most according to claim 1, it is characterised in that in preparation method, water extract-alcohol precipitation concentrated solution is joined CO2Super In critical extractor, ethanol is as entrainer, and it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15- 30MPa, temperature 30-50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, Optimum condition is: described CO2It is 5% that supercritical extraction entrainer accounts for the percent by volume of total extractant, described CO2Supercritical Extracting pressure 20MPa of extraction, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
The most according to claim 1, collyrium, it is characterised in that concentrate in said extracted method and use device, including concentrating cylinder Body, is arranged on the vaporizer of described concentration cylinder body bottom, is provided with venthole at the top of described concentration cylinder and condenses panel, It is provided with cooling liquid storage chamber in described condensation panel, is provided with at the top of described concentration cylinder and is connected with described cooling liquid storage chamber Logical feed tube and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, described Swingle is provided with scraper dish, and the web of described scraper dish contacts, at described concentration cylinder with the inwall concentrating cylinder Roof be provided with lift cylinder, the top of described swingle is through the roof of described concentration cylinder and top and described lifting air Cylinder is connected, and is provided with electric rotating machine in described swingle, the center phase of the main shaft of described electric rotating machine and described scraper dish Connect, be additionally provided with the elevating lever through roof at the top of described concentration cylinder, be provided with horn-like in the bottom of described elevating lever Inhale bubble mouth, be provided with in described elevating lever and steep the suction bubble passage that mouth is connected, on the top of described elevating lever with described horn-like suction Portion is provided with the absorption pump housing, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, and described elevating lever exists In described concentration cylinder, lifting moving is done under the effect of described regulation cylinder.
Collyrium the most according to claim 3, it is characterised in that concentrate cylinder in said extracted method described in enrichment facility Sidewall is provided with observation window, is provided with seal glass in described observation window, and described scraper dish is circular, described scraper dish External diameter with concentrate cylinder internal diameter is identical and the inner ring surface of scraper dish is connected with the main shaft of electric rotating machine by dowel bar Connecing, described vaporizer is columnar structured, and described vaporizer is connected to concentrate the diapire of cylinder by adpting flange, in described steaming It is provided with evaporation tube in sending out device, the sidewall of described vaporizer is provided with the steam inlet being connected with described evaporation tube and steam goes out Mouthful.
Collyrium the most according to claim 1, it is characterised in that be dried in said extracted method and use device, including being dried The air quantity conditioning chamber that room is connected with described hothouse, is provided with charging aperture on the roof of described hothouse, at described hothouse Bottom be provided with discharging opening, described air quantity conditioning chamber is provided with air intake passage, described hothouse is provided with air exhaust passage, its It is characterised by: between described air quantity conditioning chamber and described hothouse, be provided with dividing plate, described dividing plate is uniformly provided with pore, Being additionally provided with the cavity of lateral opening on described dividing plate, described cavity is arranged on the side by hothouse, is provided with in described cavity Electric rotating machine, is additionally provided with the swingle being connected with described electric rotating machine main shaft, is provided with upset on the surface of described swingle and stirs Mixing leaf, described swingle stretches in described hothouse, is provided with air guide channel at the center of described swingle, in described upset stirring The hot gas injection jets being connected with described air guide channel, conditioning chamber when described wind is stretched in the end of described swingle it is uniformly provided with on leaf In, in described air guide channel, it is provided with heat conduction blower fan, is provided with movable plate when described wind in conditioning chamber, in the side of described movable plate Face is provided with described pore matches air quantity adjusting plug and the air holes being arranged between adjacent air quantity adjusting plug, in described movement Mobile regulation cylinder it is provided with between the sidewall of plate and described air quantity conditioning chamber.
Collyrium the most according to claim 5, it is characterised in that be dried in said extracted method and use described wind described in device The roof of amount conditioning chamber is provided with chute, and the diapire at described air quantity conditioning chamber is provided with shifting chute, described shifting chute and described chute Trend consistent, the top of described movable plate is movably arranged in described chute by scroll wheel, and the bottom of described movable plate is logical Crossing movable block to be movably arranged in described shifting chute, described mobile regulation cylinder is arranged on the end wall of described movable block and shifting chute Between.
Collyrium the most according to claim 5, it is characterised in that be dried in said extracted method and use electric rotating described in device The main shaft of machine is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc, described cavity on described swingle Opening part be provided with protection network, described swingle through described protection network arrange.
Collyrium application in preparation treatment medicine for treating myopia the most according to claim 1.
CN201610617654.8A 2016-07-30 2016-07-30 A kind of collyrium Withdrawn CN106110066A (en)

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RU2770701C1 (en) * 2021-08-10 2022-04-21 Федеральное государственное автономное образовательное учреждение высшего образования «Дальневосточный федеральный университет» (ДВФУ) Method for obtaining co2-extract of chinese magnolia vine schisandra chinensis

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Application publication date: 20161116