CN106110066A - A kind of collyrium - Google Patents
A kind of collyrium Download PDFInfo
- Publication number
- CN106110066A CN106110066A CN201610617654.8A CN201610617654A CN106110066A CN 106110066 A CN106110066 A CN 106110066A CN 201610617654 A CN201610617654 A CN 201610617654A CN 106110066 A CN106110066 A CN 106110066A
- Authority
- CN
- China
- Prior art keywords
- cylinder
- collyrium
- radix
- swingle
- roof
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 16
- 239000012141 concentrate Substances 0.000 claims abstract description 15
- 239000012567 medical material Substances 0.000 claims abstract description 15
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 14
- 210000000582 semen Anatomy 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 7
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 7
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 238000007796 conventional method Methods 0.000 claims abstract description 5
- 230000003750 conditioning effect Effects 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 19
- 230000003028 elevating effect Effects 0.000 claims description 17
- 239000006200 vaporizer Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 239000000110 cooling liquid Substances 0.000 claims description 6
- 230000004379 myopia Effects 0.000 claims description 6
- 208000001491 myopia Diseases 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims 1
- 238000010025 steaming Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004344 low myopia Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
nullThe present invention provides a kind of collyrium，Take Fructus Lycii 10g、Arillus Longan 10g、Fructus Schisandrae Chinensis 10g、Semen Plantaginis 15g、Poria cum Radix Pini 6g、Radix Polygalae 6g、Radix Ophiopogonis 10g、Rhizoma Polygonati Odorati 3g、Radix Angelicae Sinensis 30g、Radix Bupleuri 10g、Folium Mori 10g、Caulis Perillae 10g、Poria 10g、Exocarpium Benincasae 10g、Radix Puerariae 10g、Semen Coicis 10g，Add the water of 10 times of weight of medical material，Soak 0.5h，Decoct 1 hour，Filter，Medicinal residues add the water of 8 times of weight of medical material，Decoct 1 hour，Medicinal liquid leaches，Merge twice decoction liquor，Being concentrated into 60 DEG C of relative densities is 1.05，Adding ethanol makes the percent by volume of alcohol content reach 75%，Stirring，Stand，Filter，When filtrate is concentrated into 65 DEG C, relative density is 1.25，And reclaim ethanol，Obtain concentrated solution，Use supercritical extraction，Obtain supercritical extract，Continue to concentrate，Concentrated solution is dried,It is prepared as collyrium by conventional method，Prepare ferulaic acid content high.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of collyrium.
Background technology
Traditional Chinese medicine extraction method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient to use
Measure excessive, it has not been convenient to take, had a strong impact on this product and applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of collyrium.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of collyrium, preparation method is: take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g,
Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae
10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weights of medical material
The water of amount, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes to contain
The percent by volume of alcohol amount reaches 75%, and stirring, standing, filtration, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims second
Alcohol, obtains concentrated solution, uses supercritical extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, uses routine side
Method is prepared as collyrium.
Described collyrium, joins CO by water extract-alcohol precipitation concentrated solution in preparation method2In supercritical extraction device, ethanol conduct
Entrainer, it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO2
Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, and optimum condition is: described CO2Surpass and face
It is 5% that boundary's extraction entrainer accounts for the percent by volume of total extractant, described CO2Extracting pressure 20MPa of supercritical extraction, temperature
Spend 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
Described collyrium, in said extracted method, twice concentration uses device, including concentrating cylinder, is arranged on described concentration
The vaporizer of cylinder body bottom, is provided with venthole and condenses panel, setting in described condensation panel at the top of described concentration cylinder
There is cooling liquid storage chamber, be provided with the feed tube and discharge being connected with described cooling liquid storage chamber at the top of described concentration cylinder
Pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, and described swingle is provided with scrapes dirt
Cutterhead, the web of described scraper dish contacts with the inwall concentrating cylinder, is provided with lifting on the roof of described concentration cylinder
Cylinder, the top of described swingle is connected with described lift cylinder, described through roof and the top of described concentration cylinder
Being provided with electric rotating machine in swingle, the main shaft of described electric rotating machine is connected with the center of described scraper dish, in described concentration
The top of cylinder is additionally provided with the elevating lever through roof, is provided with horn-like suction in the bottom of described elevating lever and steeps mouth, at described liter
It is provided with in fall bar and steeps, with described horn-like suction, the suction bubble passage that mouth is connected, be provided with the absorption pump housing at the top of described elevating lever,
Being provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, described elevating lever is at the work of described regulation cylinder
In described concentration cylinder, lifting moving is done under with.
Described collyrium, the sidewall concentrating cylinder in said extracted method described in enrichment facility is provided with observation window, in institute
Being provided with seal glass in stating observation window, described scraper dish is circular, and the external diameter of described scraper dish is interior with concentration cylinder
Identical and scraper dish the inner ring surface in footpath is connected with the main shaft of electric rotating machine by dowel bar, and described vaporizer is cylindrical shape
Structure, described vaporizer is connected to concentrate the diapire of cylinder, is provided with evaporation tube, in institute in described vaporizer by adpting flange
The sidewall stating vaporizer is provided with the steam inlet and steam (vapor) outlet being connected with described evaporation tube.
Described collyrium, is dried in said extracted method and uses device, be connected with described hothouse including hothouse
Air quantity conditioning chamber, is provided with charging aperture on the roof of described hothouse, is provided with discharging opening in the bottom of described hothouse, described
Air quantity conditioning chamber is provided with air intake passage, is provided with air exhaust passage on described hothouse, it is characterised in that: regulate at described air quantity
It is provided with dividing plate between room and described hothouse, described dividing plate is uniformly provided with pore, described dividing plate is additionally provided with side opening
The cavity of mouth, described cavity is arranged on the side by hothouse, is provided with electric rotating machine in described cavity, is additionally provided with and described rotation
The swingle that rotating motor main shaft is connected, is provided with upset paddle on the surface of described swingle, and described swingle stretches into described
In hothouse, it is provided with air guide channel at the center of described swingle, described upset paddle is uniformly provided with and described inducing QI
The hot gas injection jets that passage is connected, when described wind is stretched in the end of described swingle in conditioning chamber, sets in described air guide channel
There is heat conduction blower fan, be provided with movable plate when described wind in conditioning chamber, be provided with in the side of described movable plate and match with described pore
The air quantity adjusting plug closed and the air holes being arranged between adjacent air quantity adjusting plug, at described movable plate and described air quantity conditioning chamber
Mobile regulation cylinder it is provided with between sidewall.
Described collyrium, is dried in said extracted method and uses the roof of described air quantity conditioning chamber described in device to be provided with cunning
Groove, the diapire at described air quantity conditioning chamber is provided with shifting chute, and described shifting chute is consistent with the trend of described chute, described movable plate
Top be movably arranged in described chute by scroll wheel, the bottom of described movable plate is movably arranged on described by movable block
In shifting chute, described mobile regulation cylinder is arranged between described movable block and the end wall of shifting chute.
Described collyrium, is dried in said extracted method and uses the main shaft of electric rotating machine described in device to be provided with driving tooth
Dish, is provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, and the opening part of described cavity is provided with protection network, institute
State swingle to arrange through described protection network.
The application in preparation treatment medicine for treating myopia of the described collyrium.
In prior art, the original extracting method of Chinese medicine, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, no
Conveniently taking, ferulaic acid content prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation are just
Victory, it not only can start scraper dish as required and do lift adjustment as required such that it is able to realize concentrating cylinder
Inwall carries out scraping dirt process, and the descending operation that simultaneously can also regulate elevating lever as required makes horn-like bubble mouth of inhaling be in medicine
Being absorbed by the foam on surface by the absorption pump housing just above of liquid level, solves tube wall medicine dirt in conventional art medicine enrichment facility
Removing the technical deficiency of difficulty, stability in use is good and the suitability is strong.This drying equipment structure is simple, simple operation, is provided with and turns over
Turning paddle and be provided with, in upset paddle, the hot gas injection jets being connected with air quantity conditioning chamber, it is right to make while stirring medical material
Medical material is dried, and adds the speed contacted with medical material, can effectively improve medicinal material drying efficiency, and stability in use
Good, solve the technical deficiency that conventional art pharmaceutical drying device drying efficiency is low, the suitability is strong and practicality good.Chinese holly in the present invention
Qi, Arillus Longan, Fructus Schisandrae Chinensis, Semen Plantaginis, Poria cum Radix Pini's liver heat removing and eyesight improving are monarch drug, and Radix Polygalae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Bupleuri, Folium Mori are invigorated blood circulation
Blood stasis dispelling, regulating the flow of vital energy as ministerial drug, Caulis Perillae, Poria, Exocarpium Benincasae, Radix Puerariae, Semen Coicis dampness removing reduce phlegm as adjuvant, full side compatibility, benefit mutually
Evident, there is treatment myopia function.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g,
Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10
The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical
Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet
Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 4% that entrainer accounts for the percent by volume of total extractant, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/
G crude drug min, extraction time 150min, obtain supercritical extract.
See that Fig. 1: described collyrium, above-mentioned twice concentration use device, including concentrating cylinder 1, be arranged on described concentration cylinder
Vaporizer 2 bottom body 1, is provided with venthole 3 and condenses panel 4, at described condensation panel 4 at the top of described concentration cylinder 1
Inside it is provided with cooling liquid storage chamber 5, is provided with the feed liquor being connected with described cooling liquid storage chamber 5 at the top of described concentration cylinder 1
Pipe 6 and discharge pipe 7, be provided with condensation panel, the gas partial coagulation of medicine evaporation at night can be become moisture, be possible to prevent drug volatilization
Falling, the roof in described concentration cylinder 1 is provided with the swingle 8 downwardly extended, and described swingle 8 is provided with scraper dish 9, institute
The web stating scraper dish 9 contacts with the inwall concentrating cylinder 1, is provided with lift cylinder on the roof of described concentration cylinder 1
10, the top of described swingle 8 is connected with described lift cylinder 10, in institute through roof and the top of described concentration cylinder 1
Being provided with electric rotating machine 11 in stating swingle 8, the main shaft of described electric rotating machine 11 is connected with the center of described scraper dish 9,
The top of described concentration cylinder 1 is additionally provided with the elevating lever 12 through roof, is provided with horn-like suction in the bottom of described elevating lever 12
Bubble mouth 13, is provided with in described elevating lever 12 and steeps the suction bubble passage 14 that mouth 13 is connected, in described lifting with described horn-like suction
The top of bar 12 is provided with the absorption pump housing 15, is provided with regulation cylinder between the roof and described elevating lever 12 of described concentration cylinder 1
16, described elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
The sidewall of described concentration cylinder 1 is provided with observation window 17, in described observation window, is provided with seal glass 18.
Described scraper dish is circular, the external diameter of described scraper dish with concentrate cylinder internal diameter is identical and scraper dish
Inner ring surface be connected with the main shaft of electric rotating machine by dowel bar.It is not to carry out owing to scraping dirt and inhaling bubble simultaneously, so
Both can't cause mutually restriction.
Described vaporizer 2 is columnar structured, and described vaporizer 2 is connected to concentrate the end of cylinder 1 by adpting flange 19
Wall, is provided with evaporation tube 20 in described vaporizer, is provided with and is connected with described evaporation tube 20 on the sidewall of described vaporizer 2
Steam inlet 21 and steam (vapor) outlet 22.
Seeing Fig. 2: described collyrium, above-mentioned dry use device, including including that hothouse 1 is connected with described hothouse 1
Air quantity conditioning chamber 2, the roof of described hothouse 1 is provided with charging aperture 3, is provided with discharging opening in the bottom of described hothouse 1
4, described air quantity conditioning chamber 2 is provided with air intake passage 5, described hothouse 1 is provided with air exhaust passage 6, adjusts at described air quantity
It is provided with dividing plate 7 between joint room 2 and described hothouse 1, described dividing plate 7 is uniformly provided with pore 8, described dividing plate 7 also sets
There are the cavity 9 of lateral opening, described cavity 9 to be arranged on the side by hothouse 1, in described cavity 9, are provided with electric rotating machine 10,
It is additionally provided with the swingle 11 being connected with described electric rotating machine 10 main shaft, is provided with upset paddle on the surface of described swingle 11
12, described swingle 11 stretches in described hothouse 1, is provided with air guide channel 13 at the center of described swingle 11, turns over described
Turning and be uniformly provided with the hot gas injection jets 14 being connected with described air guide channel 13 on paddle 12, the end of described swingle 11 is stretched into
During described wind in conditioning chamber 2, in described air guide channel 13, it is provided with heat conduction blower fan 15, is provided with shifting when described wind in conditioning chamber 2
Dynamic plate 16, is provided with, in the side of described movable plate 16, the air quantity adjusting plug 17 matched with described pore 8 and is arranged on adjacent wind
Air holes 18 between amount adjusting plug, is provided with mobile regulation gas between the sidewall of described movable plate 16 and described air quantity conditioning chamber 2
Cylinder 19.
Roof at described air quantity conditioning chamber 2 is provided with chute 20, and the diapire at described air quantity conditioning chamber 2 is provided with shifting chute
21, described shifting chute 21 is consistent with the trend of described chute 20, and the top of described movable plate 16 is arranged by scroll wheel 22 is movable
In described chute 20, the bottom of described movable plate 16 is movably arranged in described shifting chute 21 by movable block 23, described shifting
Dynamic regulation cylinder 19 is arranged between described movable block 23 and the end wall of shifting chute 21.
The main shaft of described electric rotating machine is provided with driving fluted disc 24, described swingle is provided with and described driving fluted disc
Mutually ratcheting teeth groove 25.
Opening part at described cavity is provided with protection network 26, and described swingle is arranged through described protection network.
Embodiment 2
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g,
Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10
The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical
Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet
Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/
G crude drug min, extraction time 180min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Embodiment 3
Take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g,
Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Exocarpium Benincasae 10g, Radix Puerariae 10g, Semen Coicis 10g, add medical material 10
The water of times weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid filter
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses supercritical
Extraction, obtains supercritical extract, continues to concentrate, is dried by concentrated solution, is prepared as collyrium by conventional method, and dosage form is sheet
Agent.
Described supercritical extraction method is: joined by water extract-alcohol precipitation concentrated solution in CO2 supercritical extraction device, ethanol conduct
Entrainer, it is 5% that entrainer accounts for the percent by volume of total extractant, extracting pressure 20MPa of described CO2 supercritical extraction,
Temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Above-described embodiment Chinese crude drug all meets standards of pharmacopoeia.
Embodiment 4: ferulaic acid content determination experiment research data in collyrium of the present invention
1.1 Experimental agents: collyrium of the present invention: prepare by embodiment 1-3 method.Matched group is that reference example 1 uses
Common concentration is prepared as tablet with drying means.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column be Shim-Pack C18 (4.6mm ×
250mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability:
Chromatographic column: Shim-Pack C18 (4.6mm × 250mm, 5 μm)；Flowing phase: methanol-1% glacial acetic acid solution (35:65), detection
Wavelength 300nm；Column temperature 40 DEG C；Sample size 10 μ l.Number of theoretical plate is calculated by ferulic acid peak should be not less than 2000.Take ferulic acid comparison
Product are appropriate, accurately weighed, add methanol and make every lml solution containing 5ug, to obtain final product.The preparation of need testing solution takes content uniformity item
Under this product, finely ground, take about 0.5g, accurately weighed, put in 25ml measuring bottle, add methanol 20ml, supersound process (power 250W, frequently
Rate 40kHz) 30 minutes, let cool, add methanol to scale, shake up, filter, take subsequent filtrate, to obtain final product.Precision absorption reference substance is molten respectively
Liquid injects chromatograph of liquid with each 20ul of need testing solution, measures, to obtain final product.
1.4 experimental result
Ferulaic acid content measurement result in collyrium prepared by each embodiment
| Sample source | Ferulaic acid content (%) |
| Embodiment 1 | 1.9 |
| Embodiment 2 | 1.7 |
| Embodiment 3 | 1.8 |
| Matched group | 0.2 |
According to the result of the test of upper table, in collyrium prepared by embodiment of the present invention 1-3, ferulaic acid content is the highest
In matched group.
Embodiment 5: clinical observation
Physical data: the present invention is light to 100 examples, medium myopia patient carries out clinical observation treatment, wherein age reckling
10 years old, the maximum 35 years old, 18 years old mean age；Man's 58 examples, female 42 example.Get rid of the caused myopia of heredity.Wherein low myopia is 300
Within degree；Medium myopia is 300-600 degree, and cardinal symptom is for seeing that distant objects is smudgy.
Therapeutic Method: random packet, gives respectively and the collyrium of the embodiment of the present invention 1 preparation, drips three every day, and each 2
Drip.10 days 1 courses for the treatment of, altogether three courses for the treatment of of treatment.Avoid pungent during taking medicine.Eye exercises are done 5-10 minute after taking medicine every day 1 hour
Better.
Efficacy assessment standard: cure: see that remote thing is smudgy and wait Clinical symptom and sign to disappear, vision restoration to more than 1.0.
Effective: seeing that remote thing is smudgy and wait Clinical symptom and sign basic or the disappearance of big portion, vision is not up to 1.0, but improves more than 0.2.
Effective: seeing that the clinical symptoms such as remote thing is smudgy are clearly better or take a turn for the better, vision is not up to 1.0, increases, but improves and exist
Less than 0.2.Invalid: Clinical symptom and sign is without improving, and Index for examination has no improvement.
Therapeutic effect:
Illustrate that effect of the present invention significantly improves.
Claims (8)
1. a collyrium, it is characterised in that preparation method is: take Fructus Lycii 10g, Arillus Longan 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis
15g, Poria cum Radix Pini 6g, Radix Polygalae 6g, 10g Radix Ophiopogonis, Rhizoma Polygonati Odorati 3g, Radix Angelicae Sinensis 30g, Radix Bupleuri 10g, Folium Mori 10g, Caulis Perillae 10g, Poria 10g, Fructus Benincasae
Skin 10g, Radix Puerariae 10g, Semen Coicis 10g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add
The water of 8 times of weight of medical material, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds
Ethanol makes the percent by volume of alcohol content reach 75%, stirs, and stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25,
And reclaim ethanol, obtain concentrated solution, use supercritical extraction, obtain supercritical extract, continue to concentrate, concentrated solution is dried,
It is prepared as collyrium by conventional method.
Collyrium the most according to claim 1, it is characterised in that in preparation method, water extract-alcohol precipitation concentrated solution is joined CO2Super
In critical extractor, ethanol is as entrainer, and it is 4-6% that entrainer accounts for the percent by volume of total extractant, extracting pressure 15-
30MPa, temperature 30-50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract,
Optimum condition is: described CO2It is 5% that supercritical extraction entrainer accounts for the percent by volume of total extractant, described CO2Supercritical
Extracting pressure 20MPa of extraction, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
The most according to claim 1, collyrium, it is characterised in that concentrate in said extracted method and use device, including concentrating cylinder
Body, is arranged on the vaporizer of described concentration cylinder body bottom, is provided with venthole at the top of described concentration cylinder and condenses panel,
It is provided with cooling liquid storage chamber in described condensation panel, is provided with at the top of described concentration cylinder and is connected with described cooling liquid storage chamber
Logical feed tube and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extended, described
Swingle is provided with scraper dish, and the web of described scraper dish contacts, at described concentration cylinder with the inwall concentrating cylinder
Roof be provided with lift cylinder, the top of described swingle is through the roof of described concentration cylinder and top and described lifting air
Cylinder is connected, and is provided with electric rotating machine in described swingle, the center phase of the main shaft of described electric rotating machine and described scraper dish
Connect, be additionally provided with the elevating lever through roof at the top of described concentration cylinder, be provided with horn-like in the bottom of described elevating lever
Inhale bubble mouth, be provided with in described elevating lever and steep the suction bubble passage that mouth is connected, on the top of described elevating lever with described horn-like suction
Portion is provided with the absorption pump housing, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, and described elevating lever exists
In described concentration cylinder, lifting moving is done under the effect of described regulation cylinder.
Collyrium the most according to claim 3, it is characterised in that concentrate cylinder in said extracted method described in enrichment facility
Sidewall is provided with observation window, is provided with seal glass in described observation window, and described scraper dish is circular, described scraper dish
External diameter with concentrate cylinder internal diameter is identical and the inner ring surface of scraper dish is connected with the main shaft of electric rotating machine by dowel bar
Connecing, described vaporizer is columnar structured, and described vaporizer is connected to concentrate the diapire of cylinder by adpting flange, in described steaming
It is provided with evaporation tube in sending out device, the sidewall of described vaporizer is provided with the steam inlet being connected with described evaporation tube and steam goes out
Mouthful.
Collyrium the most according to claim 1, it is characterised in that be dried in said extracted method and use device, including being dried
The air quantity conditioning chamber that room is connected with described hothouse, is provided with charging aperture on the roof of described hothouse, at described hothouse
Bottom be provided with discharging opening, described air quantity conditioning chamber is provided with air intake passage, described hothouse is provided with air exhaust passage, its
It is characterised by: between described air quantity conditioning chamber and described hothouse, be provided with dividing plate, described dividing plate is uniformly provided with pore,
Being additionally provided with the cavity of lateral opening on described dividing plate, described cavity is arranged on the side by hothouse, is provided with in described cavity
Electric rotating machine, is additionally provided with the swingle being connected with described electric rotating machine main shaft, is provided with upset on the surface of described swingle and stirs
Mixing leaf, described swingle stretches in described hothouse, is provided with air guide channel at the center of described swingle, in described upset stirring
The hot gas injection jets being connected with described air guide channel, conditioning chamber when described wind is stretched in the end of described swingle it is uniformly provided with on leaf
In, in described air guide channel, it is provided with heat conduction blower fan, is provided with movable plate when described wind in conditioning chamber, in the side of described movable plate
Face is provided with described pore matches air quantity adjusting plug and the air holes being arranged between adjacent air quantity adjusting plug, in described movement
Mobile regulation cylinder it is provided with between the sidewall of plate and described air quantity conditioning chamber.
Collyrium the most according to claim 5, it is characterised in that be dried in said extracted method and use described wind described in device
The roof of amount conditioning chamber is provided with chute, and the diapire at described air quantity conditioning chamber is provided with shifting chute, described shifting chute and described chute
Trend consistent, the top of described movable plate is movably arranged in described chute by scroll wheel, and the bottom of described movable plate is logical
Crossing movable block to be movably arranged in described shifting chute, described mobile regulation cylinder is arranged on the end wall of described movable block and shifting chute
Between.
Collyrium the most according to claim 5, it is characterised in that be dried in said extracted method and use electric rotating described in device
The main shaft of machine is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc, described cavity on described swingle
Opening part be provided with protection network, described swingle through described protection network arrange.
Collyrium application in preparation treatment medicine for treating myopia the most according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610617654.8A CN106110066A (en) | 2016-07-30 | 2016-07-30 | A kind of collyrium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610617654.8A CN106110066A (en) | 2016-07-30 | 2016-07-30 | A kind of collyrium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106110066A true CN106110066A (en) | 2016-11-16 |
Family
ID=57255302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610617654.8A Withdrawn CN106110066A (en) | 2016-07-30 | 2016-07-30 | A kind of collyrium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106110066A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2770701C1 (en) * | 2021-08-10 | 2022-04-21 | Федеральное государственное автономное образовательное учреждение высшего образования «Дальневосточный федеральный университет» (ДВФУ) | Method for obtaining co2-extract of chinese magnolia vine schisandra chinensis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1830480A (en) * | 2005-03-07 | 2006-09-13 | 湖南德海制药有限公司 | Medicine for treating myopia and its preparation method |
-
2016
- 2016-07-30 CN CN201610617654.8A patent/CN106110066A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1830480A (en) * | 2005-03-07 | 2006-09-13 | 湖南德海制药有限公司 | Medicine for treating myopia and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 黄妍 等: "益视明目饮治疗青少年近视33例临床观察", 《湖南中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2770701C1 (en) * | 2021-08-10 | 2022-04-21 | Федеральное государственное автономное образовательное учреждение высшего образования «Дальневосточный федеральный университет» (ДВФУ) | Method for obtaining co2-extract of chinese magnolia vine schisandra chinensis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107412331B (en) | Nasal preparation for treating rhinitis and preparation method and application thereof | |
| CN116370552B (en) | Lotion and extraction process of extract thereof | |
| CN101953980B (en) | Allium macrostemon and pepperweed seed mixture for treating chronic obstructive pulmonary disease (COPD) by adopting phlegm removing and turbidity resolving method | |
| CN106235341A (en) | A kind of bamboo shoot edible fiber extracting method and the granule for the treatment of constipation | |
| CN106075360A (en) | A kind of invigorating spleen prescription compositions | |
| CN103550706A (en) | Applications of different elution parts of phlegm-reducing and dysphagia-treating powder, dryness-moistening soup, adenophora stricta and radix ophiopogonis soup as well as qi-tonifying and spleen-strengthening soup in medicines for treating esophagus cancers | |
| CN105998144A (en) | Extraction method of fiveleaf gynostemma herb saponin and fiveleaf gynostemma herb saponin extract | |
| CN106110066A (en) | A kind of collyrium | |
| CN106266935A (en) | A kind of Chinese medicine and western medicine compound medicine for giving-up drug-taking and preparation method thereof | |
| CN106262952A (en) | A kind of wheat edible fiber extracting method and grain dietary fiber Antilipemic slimming tea | |
| CN106074624A (en) | A kind of spirulina extracting method and the health tea for the treatment of hyperlipemia | |
| CN106420656A (en) | Trollflower effervescent tablet and preparation method thereof | |
| CN106074289A (en) | The extracting method of a kind of Aloe and sun care preparations | |
| CN106074646A (en) | The process of preparing Chinese medicine extracting method of a kind of Radix Ginseng decoction pieces and the ginseng composition of pulmonary fibrosis resistant | |
| CN106166187A (en) | A kind of defervescence plaster used | |
| CN107595714A (en) | A kind of Gentrin Knotweed P.E and preparation method thereof and the application in cosmetics | |
| CN110559418B (en) | Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof | |
| CN106983737A (en) | The new application of picrorhiza rhizome vanillic acid | |
| CN106074908A (en) | A kind of ventilating nasal patch | |
| CN106214729A (en) | A kind of blue berry extracting method and the bathomorphic health tea for the treatment of | |
| CN106236619A (en) | The extracting method of a kind of Aloe and Aloe acne eliminating cream | |
| CN106110093A (en) | A kind of wushicha granules and its preparation method and application | |
| CN108066494B (en) | Liquid medicine with frequent nocturia and preparation method thereof | |
| CN105902632A (en) | Extracting method of total glucosides of paeony and extracts of total glucosides of paeony | |
| CN106212801A (en) | The extracting method of a kind of green tea extractive liquor and the tea beverage for the treatment of hyperlipemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161116 |