CN109758391A - It is a kind of to have effects that the plant composition of antiallergic - Google Patents
It is a kind of to have effects that the plant composition of antiallergic Download PDFInfo
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- CN109758391A CN109758391A CN201811488361.XA CN201811488361A CN109758391A CN 109758391 A CN109758391 A CN 109758391A CN 201811488361 A CN201811488361 A CN 201811488361A CN 109758391 A CN109758391 A CN 109758391A
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Abstract
Have effects that the plant composition of antiallergic, the antiallergy plant composition include radix scutellariae root extract, Radix Notoginseng root extract the invention discloses a kind of, tea extract, honeysuckle flower extract, peony root extractive, rough gentian root extract, one of Roman chamomile flower extract etc. or a variety of.The present invention is highly-safe using the antiallergic composition of natural plant extracts preparation, has no toxic side effect, small to skin irritation, and property is stablized, and is added to simple process in cosmetics；And there is preferable hyaluronidase rejection ability and free radical scavenging ability, effectively it can slow down and improve skin allergy, inflammation symptom, have the effect of anti-inflammatory, Shu Min, moisturizing, in antiallergic cosmetics with good application prospect.
Description
Technical field
It is specially a kind of to have effects that the plant composition of antiallergic the invention belongs to plant application and cosmetic field.
Background technique
Sensitive is a kind of special skin type, be mainly characterized by having dry skin, be easy it is tight and rubescent, by
It can produce itch, furfur to minimal irritation or even burn and feel with shouting pain etc., serious person can produce unhealthy emotion or psychosis
Shape.Compared with normal skin, there is barrier function damage or abnormality of nerve function in sensitive skin, it more difficult in resisting the external world
The invasion of stimulant and anaphylactogen are easy to happen a series of scytitis caused by stimulations or allergy and react, then further damage
Evil skin barrier structure and nerve endings, lead to vicious circle.
Epidemiological study points out have 51.4% women and 38.2% male in Britain, there is the experience of skin allergy.
Equally, it oneself is sensitive that discovery, which has 52% women to claim, in the phone investigation in the U.S..In addition, in France
Point out that 52% participant is sensitive in one epidemiological study, and women (59%) is significantly higher than male
(44%).It can be seen that the incidence of allergic skin is very high, have become a global problem.
In recent years, with the development of industry, air pollution is increasingly severe, in addition the increase and change of people's life stress
The improper use of cosmetic, the skin barrier function of people are damaged to a certain extent, and the probability that sensitive skin occurs is more next
It is bigger, therefore, have effects that the cosmetics of antiallergic are increasingly subject to the attention of people.Currently used anti-sensitizer has glycyrrhizic acid two
Potassium, α-bisabolol etc., these anti-sensitizers have certain defect, contain as dipotassium glycyrrhizinate will increase the ion in cosmetics
Amount, keeps cosmetics unstable；α-bisabolol inherently has irritation.With theories such as " green, natural, environmental protection, safety "
Go deep into, efficient, safe, natural antiallergic active constituent is found from natural plant raw material, will become antiallergic cosmetics study
A kind of trend.
Patent CN 103751530 discloses a kind of extract with the Chinese medicine composition of antiallergic and its application, should
Composition is made of cortex dictamni, Asian puccoon, radix saposhnikoviae, Radix Angelicae Sinensis, radix polygonati officinalis, Radix Glycyrrhizae, and extract is obtained by the way of compound collecting, is not had
There is the property for fully considering each raw material using suitable extraction process.Patent CN 108653090 discloses a kind of antiallergic combination
Object, the composition are made of plum berry extract, spikemoss extract, roselle extract, the mechanism of not clear antiallergic.
Summary of the invention
The purpose of the invention is to overcome the defect of cosmetics anti-sensitizer used at present, a kind of efficient, safety is provided
Natural plants antiallergic composition, the plant composition include following plant extracts: Baical Skullcap root P.E, Notogineng Extract,
Tea extract, honeysuckle flower extract, Cortex Moutan extract, Radix Gentianae extract, Roman chamomile extract.Antiallergic of the invention
Composition can effectively inhibit hyaluronidase activity, remove free radical, effectively can slow down and improve the diseases such as skin allergy, inflammation
Shape has the effect of anti-inflammatory, Shu Min, moisturizing.
Plant composition of the invention is achieved through the following technical solutions:
It is of the present invention it is a kind of have effects that the plant composition of antiallergic, the weight percent of each extract in the composition
Number are as follows:
Further, in the plant composition each extract the preparation method comprises the following steps:
Step 1, by the corresponding plant material of each extract, individually powder is beaten in drying, and it is dry to get each plant material to cross No. three sieves
Dry powder；
Step 2 extracts each plant material dried powder by solvent, obtains corresponding extracting solution；
Each extracting solution is concentrated under reduced pressure respectively, is dry to get each extract by step 3；
Step 4 is compounded extract obtained, to obtain plant composition.
Further, in the preparation method step 2, scutellariae,radix, Roots of Panax Notoginseng, tealeaves, gentian, Roman chamomile difference
It is extracted using alcohol extracting method, obtains corresponding extracting solution；Tree peony root, honeysuckle flowers are utilized respectively deionized water and extract, and obtain
To corresponding extracting solution.
Further, alcohol extracting method described in preparation method step 2 specifically: concentration of alcohol is 30~80%, solid-liquid ratio
It (g/mL) is 1:10~1:30, Extracting temperature is 40~80 DEG C, and extraction time is 0.5~3.0h, and extraction time is 1~3 time；Its
Middle Roots of Panax Notoginseng extracting solution carries out enriching and purifying with macroreticular resin again, collects the eluent of 30~80% concentration of alcohol.
Further, water extraction described in preparation method step 2 specifically: feed liquid mass ratio is 1:10~1:30, is mentioned
Taking temperature is 40~80 DEG C, and extraction time is 0.5~2.0h, and extraction time is 1~3 time.
Further, in preparation method step 3, the temperature of the reduced pressure is 45~60 DEG C, and drying mode is true
Sky is dry or is freeze-dried.
Further, in step 4, extract compounding solvent used is butanediol, propylene glycol or glycerol.
Plant composition provided by the invention has preferable hyaluronidase rejection ability and/or radical scavenging activity
Power.
Plant composition provided by the invention can be used as active constituent addition antiallergic into cosmetics, the cosmetics agent
Type is not particularly limited, and can be cream, lotion and aqua, gel etc..
The invention has the benefit that
1. plant society raw material of the invention is easy to get, preparation process is simple, and property is stablized, and is easily added to various doses
In the cosmetics of type, it is suitable for industrialized production；
2. plant composition of the present invention can effectively inhibit hyaluronidase activity, free radical is removed, effectively can slow down and change
The symptoms such as kind skin allergy, inflammation, have the effect of anti-inflammatory, Shu Min, moisturizing, and safe and nontoxic, small to skin irritation,
It has broad application prospects in antiallergic cosmetics.
Detailed description of the invention
Fig. 1 is schematic diagram of the Genes For Plant Tolerance sensitive composition to the rejection ability of hyaluronidase activity；
Fig. 2 is schematic diagram of the Genes For Plant Tolerance sensitive composition to DPPH free radical scavenging ability；
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, the present invention is done into one below by embodiment
The detailed description of step, but mode of the invention is without being limited thereto.
The preparation of 1 plant extracts of embodiment
(1) scutellariae,radix dried powder 50g is taken, the ethanol solution of 1.25L 40% is added, 90min, mistake are extracted in 50 DEG C of water-baths
Filter is concentrated under reduced pressure, and is dried in vacuo in 45 DEG C up to radix scutellariae root extract；
(2) tea-drying powder 50g is taken, the ethanol solution of 750mL 50% is added, 50min, decompression are extracted in 45 DEG C of water-baths
Concentration is dried in vacuo up to tea extract in 45 DEG C；
(3) 500mL distilled water is added in extracting honeysuckle dried powder 50g, and 60min is extracted in 85 DEG C of water-baths, extracts twice, mistake
Filter merges extract twice, is concentrated and dried up to Honegsukle flower P.E；
(4) tree peony root dried powder 50g is taken, the ethanol solution of 1L 80% is added, 1.0h is extracted in 60 DEG C of water-baths, and filtering is dense
Contracting is dried to obtain peony root extractive；
(5) gentian dried powder 50g is taken, 1L distilled water is added, 2h, filtering are extracted in 80 DEG C of water-baths, and concentrate drying obtains
Rough gentian root extract；
(6) Roman chamomile dried powder 50g is taken, the ethanol solution of 1.5L 70% is added, 70 DEG C of water-baths are extracted 2h, subtracted
Pressure concentration obtains Roman chamomile extract in 45 DEG C of vacuum drying；
(7) Roots of Panax Notoginseng dried powder 50g is taken, the ethanol solution of 500mL 80% is added, 60 DEG C of water-baths are extracted 2h, filtered
To Roots of Panax Notoginseng extracting solution, revolving removal ethyl alcohol collects the eluent of 70% concentration of alcohol, decompression with AB-8 macroporous resin purification
Concentration is dried in vacuo up to Radix Notoginseng root extract in 45 DEG C.
The preparation of 2 plant composition of embodiment (I)
The weight percent of each extract are as follows:
The specification of quality of gained antiallergic plant composition is as follows:
The 1 antiallergic plant composition specification of quality of table
The preparation of 3 plant composition of embodiment (II)
The weight percent of each extract are as follows:
The specification of quality of gained antiallergic plant composition is as follows:
The 2 antiallergic plant composition specification of quality of table
4 plant composition of embodiment detects hyaluronidase activity rejection ability
Hyaluronidase Inhibition test is most typical antiallergic activity rating in-vitro method, is with hyaluronic acid enzyme inhibition rate
The antiallergic activity of metrics evaluation substance, hyaluronic acid enzyme inhibition rate is bigger, then antiallergic activity is stronger.The present invention is with Elson-
Morgan improved method carries out external hyaluronidase Inhibition test, evaluates antiallergic effect of prescription, is control with dipotassium glycyrrhizinate
(10mg/mL).Specific step is as follows:
Take the CaCl of 0.1mL2Solution and 0.5mL hyaluronidase solution are in 37 DEG C of heat preservation 20min；It is (anti-that sample liquid is added
Sensitive composition I) 0.5mL, continues in 37 DEG C of heat preservation 20min；37 DEG C of heat preservation 30min of 0.5mL Sodium Hyaluronate liquid are added, room temperature is put
Set 5min；The NaOH solution and 0.5mL acetylacetone,2,4-pentanedione solution of 0.1mL 0.4mol/L is added, is placed in boiling water bath and heats 15min
Cooling 5min is carried out with ice water immediately afterwards；Ehrlich's reagent 1.0mL is added, places colour developing 20min, measures it at 535nm
Absorbance value.The results are shown in attached figure 1.
As seen from the figure, compared with the positive control dipotassium glycyrrhizinate of similar concentration, plant antiallergic prescription is to hyaluronic acid
The inhibiting rate of enzyme is higher by 50% or so than its, therefore, the results showed that, resulting antiallergic prescription inhibits with preferable hyaluronidase
Ability can safeguard barrier cell function to a certain extent, protect skin from environmental stimuli, play antiallergic effect.
5 plant composition of embodiment detects DPPH free radical scavenging ability
A large amount of free radicals are to the root that the Oxidative demage of mast cell and basophilla is that allergy occurs.Inhibit free radical living
Property, the degeneration that the excessive free radicals generated after environmental stimuli act on lower structure function of cell can be effectively relieved, and then safeguard packet
The normal barrier structure of various organs including skin is included, prevents human body from condition susceptible occur to a certain extent.Therefore, object is measured
The elimination effect of confrontation free radical can reflect it and inhibit sensitive effect.The present invention is evaluated with DPPH free radical scavenging activity
Antiallergic effect of prescription, the specific steps are as follows:
Prescription compositional liquor is diluted 25,50,100,200 times respectively, i.e. concentration is respectively after 4%, 2%, 1%, 0.5%,
It is accurate to draw 1mL sample solution, 5mL DPPH solution is added, (25 DEG C) are protected from light and stand 30min at room temperature after mixing, measurement
Light absorption value at 517nm calculates clearance rate, and DPPH free radical scavenging activity formula is as follows:
Y=(A0-A1-A2)/A0* 100%
Y-clearance rate, %
A0The absorbance of -1mL distilled water+5mL DPPH solution
A1- 1mL sample/Trolox titer+5mL DPPH solution absorbance
A2- 1mL sample/Trolox titer+ethanol solution absorbance (eliminating the error between different samples).
Antiallergic plant composition group is shown in attached drawing 2 to DPPH Scavenging activity, and as seen from the figure, 2% composition is to DPPH freedom
The Scavenging activity of base illustrates that prescription liquid has preferable free radical scavenging ability, can effectively block Anaphylactic mediator up to 75%
Release reduces it and injures to tissue and cell bring, to safeguard the normal barrier structure of skin, reaches antiallergic effect.
Claims (9)
1. a kind of have effects that the plant composition of antiallergic, it is characterised in that: the plant composition includes following extract:
Baical Skullcap root P.E, Notogineng Extract, tea extract, honeysuckle flower extract, peony root extractive, Radix Gentianae extract, white flower spring
Yellow chrysanthemum extract.
A kind of has effects that the plant composition of antiallergic 2. according to claim 1, which is characterized in that the plant society
The weight percent of each extract in object are as follows:
A kind of has effects that the plant composition of antiallergic 3. according to claim 2, it is characterised in that the plant society
In object each extract the preparation method comprises the following steps:
Step 1, by the corresponding plant material of each extract, individually powder is beaten in drying, crosses No. three sieves to get each plant material xeraphium
End；
Step 2 extracts each plant material dried powder by solvent, obtains corresponding extracting solution；
Each extracting solution is concentrated under reduced pressure respectively, is dry to get each extract by step 3；The temperature of reduced pressure is 45~60 DEG C,
Drying mode is vacuum drying or freeze-drying；
Step 4 is compounded extract obtained, to obtain plant composition.
A kind of has effects that the plant composition of antiallergic 4. according to claim 3, it is characterised in that radix scutellariae in step 2
Root, Roots of Panax Notoginseng, tealeaves, gentian, Roman chamomile are utilized respectively alcohol extracting method and extract, and obtain corresponding extracting solution；Tree peony
Root, honeysuckle flowers are utilized respectively deionized water and extract, and obtain corresponding extracting solution.
A kind of has effects that the plant composition of antiallergic 5. according to claim 4, it is characterised in that alcohol extracting described in step 2
Method specifically: concentration of alcohol is 30~80%, and feed liquid mass ratio is 1:10~1:30, and Extracting temperature is 40~80 DEG C, when extraction
Between be 0.5~3.0h, extraction time be 1~3 time；Wherein Roots of Panax Notoginseng extracting solution carries out enriching and purifying with macroreticular resin again, collects
The eluent of 30~80% concentration of alcohol.
A kind of has effects that the plant composition of antiallergic 6. according to claim 4, it is characterised in that water described in step 2 mentions
Method specifically: solid-liquid ratio (g/mL) is 1:10~1:30, and Extracting temperature is 40~80 DEG C, and extraction time is 0.5~2.0h, is extracted
Number is 1~3 time.
7. a kind of according to claim 3 or 4 or 5 or 6 have effects that the plant composition of antiallergic, it is characterised in that step
Each extract compounding solvent used is butanediol, propylene glycol or glycerol in 4.
A kind of has effects that the plant composition of antiallergic 8. according to claim 7, it is characterised in that the plant society
Object has preferable hyaluronidase rejection ability and free radical scavenging ability.
A kind of has effects that the plant composition of antiallergic 9. according to claim 8, it is characterised in that displant compositions
Can be as active constituent addition antiallergic into cosmetics, the State of cosmetics includes cream, lotion, aqua or gel.
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Cited By (3)
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| CN110075059A (en) * | 2019-05-29 | 2019-08-02 | 广州睿晞生化科技有限公司 | It is a kind of can the antipruritic reparation of antiallergic composition |
| CN111467447A (en) * | 2020-04-18 | 2020-07-31 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for inhibiting skin allergy |
| CN115844784A (en) * | 2022-12-22 | 2023-03-28 | 广州市科能化妆品科研有限公司 | Allergy-relieving and anti-inflammatory composition for dry skin and application and preparation method thereof |
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Application publication date: 20190517 |
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