CN107823472A - One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation and its preparation method and application - Google Patents
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation and its preparation method and application Download PDFInfo
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Abstract
The invention belongs to natural products formulation art, being related to one kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation and its preparation method and application, and there is anti-inflammatory antiallergic itching-relieving efficacies compound formulation to include purslane extract 1 10%, phllostachys pubescens leaf ext 20 30%, dendrobium candidum extract 1 30%, kuh-seng root extract 1 10%, licorice root extract 1 10%, honeysuckle flower extract 1 10%, oat extract 1 10% and surplus auxiliary material according to the percentage by weight of feed components.By using appropriate each material rate, the effect of having given full play to each component, effect is better than each single dose effect, possesses good anti-inflammatory, antiallergic, itching-relieving efficacies, and improves resistance threshold value of the skin to extraneous stimulant, so as to mitigate the sensitivity phenomenon of skin.
Description
Technical field
The invention belongs to natural products formulation art, and being related to one kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation and its system
Preparation Method and application.
Background technology
With the rapid development of economy, people pursue more and more higher to the state of skin, along with the life of modern, work
The pressure of work, the exception of diet work and rest rule, the health status of skin are also gradually reduced, and skin is also easy to produce sensitivity for a long time
Phenomenon, it is allergic to be primarily referred to as when skin is stimulated such as the cosmetics of adverse reaction, chemicals, pollen, some by various
Food, air etc. of pollution, cause skin occur it is red and swollen, itch, peel and the anomaly such as allergic dermatitis.
With the quickening of social modernization's step, used in sensitive group comprising some to pursue the skin cares such as quick-acting
The product of some improper compositions is added, and then causes the skin sensitivity phenomenon occur, increasing people is just by " allergy "
Puzzlement, have antianaphylaxis function cosmetics by by the welcome and accreditation of a large amount of consumers.
The patent that China Patent No. is 201010103898.7 discloses a kind of composite nano-emulsion for resisting skin allergy
And preparation method thereof, although there is certain antiallergic effect, it is chemical synthesis substance that it, which is formulated main component, Hen Duohua
Stimulation can be had to the skin of human body by learning synthetic, or even be caused allergic.
Therefore, there is an urgent need to develop the antianaphylactic medicine of some antianaphylactic cosmetics and commodity, the present invention is mainly
It is to provide a kind of pure natural antianaphylactic plant extract composition formula, can be as the antianaphylactic work(of cosmetics, commodity etc.
Can additive.
The content of the invention
To overcome disadvantages mentioned above, present invention aims at provide it is a kind of have anti-inflammatory antiallergic itching-relieving efficacies compound formulation and its
Preparation method and application.
The technical solution adopted by the present invention is：The percentage by weight of feed components is：Purslane extract 1-10%, hair
Bamboo extractive 20-30%, dendrobium candidum extract 1-30%, kuh-seng root extract 1-10%, licorice root extract 1-10%, honeysuckle
Flower extract 1-10%, oat extract 1-10% and surplus auxiliary material.
In the above-mentioned material component of the present invention, the effect of the pure natural raw material of anti-inflammatory antiallergic itching-relieving efficacies compound formulation such as
Under：
Purslane extract：Purslane mainly contains flavonoids, polysaccharide, alkaloids, triterpene alcohols, organic acid, catechu
Phenol amine substance, and a variety of nutriments such as other vitamin and minerals, have antibacterial, antiviral, anti-aging, enhancing immune
Power and other effects.The norepinephrine and neurohormone contained, have and play vessel retraction effect, hypotension and reduction tissue
The function of bleeding.1. external application can be used for treat burn, otalgia, insect bites, inflammation, cutaneous pain, ulcer, pruitus,
Eczema and abscess.2. being used for personal nursing and cleaning products, cytotoxicity caused by surfactant and stimulation can be reduced, is had
There are antiinflammatory action and anti-irritant effect.Damaged 3. can reduce caused by UVA, there is anti-light toxic action.
Phllostachys pubescens leaf ext：The leaf of bamboo is containing based on phenolic compound, to there is polyphenol components and chromocor compound.But it can use
Make only triein and the p-Coumaric Acid of quality standard, the former is a chromocor compound, and the latter is a phenolic compound, and the leaf of bamboo carries
Thing efficacy performance is taken in antibiotic property, antioxidant, moisture retention and anti-inflammatory.1. in water extract antibiotic property, bamboo extractive pair
Staphylococcus aureus, Escherichia coli and Bacillus subtilis have preferable antibiotic property, their minimal inhibitory concentration is respectively 0.25%,
0.125% and 0.125%, but bamboo extractive is to mould, the effect of saccharomycete and unobvious.2. Moso Bamboo Leaves water extract has
Certain antioxidant, elimination factor of the concentration in 1mg/mL that disappear to free radical DPPH is 35%, free to hydroxyl radical free radical and super oxygen
The elimination factor of base respectively reaches 65% and 71%.3. Moso Bamboo Leaves water extract causes rat toes swelling to have suppression carrageenan, when dense
For degree in 30mg/Kg, inhibiting rate is 22 ± 7%（Determine within 3 hours）, there is certain anti-inflammatory.
Dendrobium candidum extract：Main pharmacodynamics composition is polysaccharide, alkaloid, glucosides, luxuriant and rich with fragrance class, bibenzyl and amino acid etc..
Content of the polysaccharide in dendrobium candidum is high, and with the effect such as good antitumor, anti-oxidant and strengthen immunity, dendrobium polysaccharide
Belong to one kind of active polysaccharide, have anti-inflammatory, it is antiviral, repair itself improve immunity the effect of.
Kuh-seng root extract：Separation has been extracted in kuh-seng and has identified over one hundred kind of chemical composition, mainly there are a variety of alkaloids, such as
Matrine（matrine）, oxymatrine（oxymatrine）, only a few is Bispiperidines（dipiperidine-type）；It is yellow
Ketone compounds majority is flavanone and flavanonol, and minority is flavones, isoflavones, chalcone and its alcohol, wherein only 3
Kind is glycosides；Volatile oil component is using eicosane hydrocarbon as main component, from the point of view of structure type, based on alkene, secondly for alkane and
Alcohols, still contain acid, aldehyde, ketone, phenol etc., be again aliphatic acid, predominantly unrighted acid.1. beautifying skin-protection function：It is cold in nature, have
Heat-clearing and damp-drying drug, the effect of desinsection, kuh-seng bath can remove damp-heat in lower-JIAO, and desinsection is antipruritic, have to pruitus slow well
Solution act on, can Bergamot Mint Extract, dredge and restrain pore, remove skin endotoxin contamination, abundant herbal nutrition, promote
The growth and reparation of damaged blood vessels nerve cell, recover subcutaneous capillary cell viability, skin, which reappears, to compact fine and smooth, plays U.S.
Hold the effect of skin care.2. antibacterial and anti-inflammation functions：Kuh-seng ether extract and alcohol extract have stronger antibacterial work to staphylococcus aureus
With；Kuh-seng flooding agent has suppression to make trichophyton, Trichophyton concentricum, Trichophyton schoenleini, Du small gemma tinea bacterium of big belly difficult to understand etc.
With.3. kuh-seng has good antiallergic to act on, matrine can reduce the release of Anaphylactic mediator, be immunodepressant.
Licorice root extract：Licorice generally comprises：Glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza are sweet
Proliferation function of the careless extract to myocyte, the facilitation to vascular endothelial cell proliferation, to the type of collagen -4 generation
Promote, have facilitation in activity of raising skin etc. to studies have shown that licorices such as the suppression of NO generations, can use
In anti-ageing cosmetics；Licorice has suppression melanin, the effect of skin whitening simultaneously；Have to some bacteriums obvious
Inhibitory action, it can be used as antiinflammatory.
Honeysuckle flower extract：The stem of honeysuckle, leaf, middle Main Ingredients and Appearance is spent to be chlorogenic acid, chlorogenic acid clinically has anti-
The effect of bacterium anti-inflammatory.Its action and efficacy is embodied in anti-inflammatory, the aspect of antibacterial two.
Oat extract：Beta glucan and flavone compound are mainly contained, possesses excellent senile-resistant efficacy, can be comforted
Flat fine wrinkles, improve dermatoglyph degree.The beta glucan wherein contained.The synthesis of collagen can be promoted, eliminate free radical,
With oxidation resistant effect；With relatively good moistening effect, there is the effect of water holding.
Preferably, the percentage by weight of feed components is：Purslane extract 5-10%, phllostachys pubescens leaf ext 20-30%,
Dendrobium candidum extract 10-20%, kuh-seng root extract 2-5%, licorice root extract 3-8%, honeysuckle flower extract 5-10%, oat
Extract 2-5% and surplus auxiliary material.
Further, auxiliary material is NMF, and the NMF is the mixture of propane diols and glycerine.
Preferably, propane diols and glycerine according to weight ratio are 1 in the NMF:1.5 mixing.
Further, purslane extract is prepared by following technique：Purslane is taken to dry, using 95% ethanol conduct
Entrainment reagent, CO2 supercritical extracts, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；
Residue after supercritical extract, enzyme hydrolysis is carried out, extracting in water, filtering, extract solution addition activated carbon and carclazyte, centrifugation, concentration are dry
It is dry, obtain extract B；Extract A and extract B are well mixed, obtain purslane extract.
Further, phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, use is overcritical
CO2 fluid extraction process, and be dispersed in water, inhaled using macropore by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried
Attached resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate uses polyamide again
Absorption, is eluted, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material after the completion of absorption with ethanol solution.
Further, dendrobium candidum extract is prepared by following technique：By dendrobium candidum in 50-70 DEG C of vacuum drying
1-3h, 60-90 mesh sieves are then crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifugation
4500-5500r/min removes slag, and then by supernatant concentration, distilled water dissolving is subsequently added into, then in 8000-12000r/min
5-15min is centrifuged, precipitation is dried to obtain dendrobium candidum extract.
Present invention also offers a kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, including following step
Suddenly：Auxiliary material and oat extract are stirred, and are warming up to 70-75 DEG C, stirs to component and is completely dissolved, then stirring cooling
To 30-40 DEG C, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract are sequentially added, ultrasonic 0.5-1 hours,
Licorice root extract, honeysuckle flower extract and kuh-seng root extract are sequentially added into mixture again, is stirred, ultrasonic 0.5-
1 hour, obtain finished product.
It is described to resist with anti-inflammatory present invention also offers a kind of application with anti-inflammatory antiallergic itching-relieving efficacies compound formulation
Quick itching-relieving efficacies compound formulation is as cosmetics, the functional additive of the antianaphylactic medicine of commodity.
The present invention is beneficial to be had technical effect that：Present invention is generally directed to skin easily other skin cares of quick or improper use
Caused by allergic crowd, be also easy to produce heating for skin, it is red and swollen, the symptom such as shouting pain, there is good effect.Purslane carries
Thing is taken to mainly contain flavonoids, polysaccharide, alkaloids, triterpene alcohols, organic acid, Catecholamine matter, and other dimensions
A variety of nutriments such as raw element and mineral matter, have antibacterial, antiviral, anti-aging, strengthen immunity and other effects；Moso Bamboo Leaves extract
Thing：The leaf of bamboo is containing based on phenolic compound, to there is polyphenol components and chromocor compound；Dendrobium candidum extract, Dendrobium Sw
In main pharmacodynamics composition for polysaccharide, alkaloid, glucosides, luxuriant and rich with fragrance class, bibenzyl and amino acid etc., dendrobium polysaccharide belongs to active polysaccharide
One kind, have anti-inflammatory, it is antiviral, repair itself improve immunity the effect of；Kuh-seng root extract, licorice root extract, bears
Coltsfoot extract, oat extract etc. all have the resistance threshold value for improving skin to extraneous stimulant, so as to mitigate the quick of skin
Feel phenomenon.
Embodiment
The content that the present invention is furture elucidated with reference to embodiments, but the present invention is not restricted to the model of following examples
Enclose.
Embodiment 1
One kind provided by the invention has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, raw materials used medicine：Purslane extract, mao bamboon
It is prepared by leaf extract, dendrobium candidum extract, kuh-seng root extract, licorice root extract, honeysuckle flower extract, oat extract
Method is：Using purslane, Moso Bamboo Leaves, dendrobium candidum, radix sophorae, licorice, honeysuckle flowers, oat raw material respectively with 95% ethanol
Derect seething, each extract is then condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower respectively and carry
Take thing, Egyptian blue water lily flower extract, little Cassia tora seed extract.Auxiliary material includes propane diols and glycerine can be bought by market.
Wherein, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract can also use the present embodiment as follows
Method is made：
Purslane extract is prepared by following technique：Take purslane to dry, surpassed using 95% ethanol as entrainment reagent, CO2
Critical extraction, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；After supercritical extract
Residue, enzyme hydrolysis, extracting in water, filtering, extract solution addition activated carbon and carclazyte are carried out, is centrifuged, is concentrated and dried, obtains extract
B；Extract A and extract B are well mixed, obtain purslane extract.
Phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, extracted using supercritical fluid CO 2
Method is taken, and is dispersed in water by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried, using macroporous absorbent resin dynamic
Absorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, absorption
After the completion of eluted with ethanol solution, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Dendrobium candidum extract is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then
60-90 mesh sieves are crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifuges 4500-
5500r/min removes slag, and then by supernatant concentration, is subsequently added into distilled water dissolving, then centrifuges 5- in 8000-12000r/min
15min, precipitation is dried to obtain dendrobium candidum extract.
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, and the percentage by weight of feed components is：Purslane is extracted
Thing 1%, phllostachys pubescens leaf ext 20%, dendrobium candidum extract 1%, kuh-seng root extract 1%, licorice root extract 1%, honeysuckle flowers carry
Thing 1%, oat extract 1% and auxiliary material 74% are taken, wherein auxiliary material is the mixture of propane diols 29.6% and glycerine 44.4%.
A kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, comprises the following steps：By auxiliary material and oat
Extract is stirred, and is warming up to 70-75 DEG C, is stirred to component and is completely dissolved, and then stirring is cooled to 30-40 DEG C, then according to
Secondary addition purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then into mixture according to
Secondary addition licorice root extract, honeysuckle flower extract and kuh-seng root extract, stir, ultrasonic 0.5-1 hours, obtain into
Product.
Embodiment 2
One kind provided by the invention has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, raw materials used medicine：Purslane extract, mao bamboon
It is prepared by leaf extract, dendrobium candidum extract, kuh-seng root extract, licorice root extract, honeysuckle flower extract, oat extract
Method is：Using purslane, Moso Bamboo Leaves, dendrobium candidum, radix sophorae, licorice, honeysuckle flowers, oat raw material respectively with 95% ethanol
Derect seething, each extract is then condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower respectively and carry
Take thing, Egyptian blue water lily flower extract, little Cassia tora seed extract.Auxiliary material includes propane diols and glycerine can be bought by market.
Wherein, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract can also use the present embodiment as follows
Method is made：
Purslane extract is prepared by following technique：Take purslane to dry, surpassed using 95% ethanol as entrainment reagent, CO2
Critical extraction, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；After supercritical extract
Residue, enzyme hydrolysis, extracting in water, filtering, extract solution addition activated carbon and carclazyte are carried out, is centrifuged, is concentrated and dried, obtains extract
B；Extract A and extract B are well mixed, obtain purslane extract.
Phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, extracted using supercritical fluid CO 2
Method is taken, and is dispersed in water by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried, using macroporous absorbent resin dynamic
Absorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, absorption
After the completion of eluted with ethanol solution, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Dendrobium candidum extract is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then
60-90 mesh sieves are crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifuges 4500-
5500r/min removes slag, and then by supernatant concentration, is subsequently added into distilled water dissolving, then centrifuges 5- in 8000-12000r/min
15min, precipitation is dried to obtain dendrobium candidum extract.
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, and the percentage by weight of feed components is：Purslane is extracted
Thing 5%, phllostachys pubescens leaf ext 20%, dendrobium candidum extract 10%, kuh-seng root extract 2%, licorice root extract 3%, honeysuckle flowers carry
Thing 5%, oat extract 2% and auxiliary material 53% are taken, wherein auxiliary material is the mixture of propane diols 21.2% and glycerine 31.8%.
A kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, comprises the following steps：By auxiliary material and oat
Extract is stirred, and is warming up to 70-75 DEG C, is stirred to component and is completely dissolved, and then stirring is cooled to 30-40 DEG C, then according to
Secondary addition purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then into mixture according to
Secondary addition licorice root extract, honeysuckle flower extract and kuh-seng root extract, stir, ultrasonic 0.5-1 hours, obtain into
Product.
Embodiment 3
One kind provided by the invention has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, raw materials used medicine：Purslane extract, mao bamboon
It is prepared by leaf extract, dendrobium candidum extract, kuh-seng root extract, licorice root extract, honeysuckle flower extract, oat extract
Method is：Using purslane, Moso Bamboo Leaves, dendrobium candidum, radix sophorae, licorice, honeysuckle flowers, oat raw material respectively with 95% ethanol
Derect seething, each extract is then condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower respectively and carry
Take thing, Egyptian blue water lily flower extract, little Cassia tora seed extract.Auxiliary material includes propane diols and glycerine can be bought by market.
Wherein, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract can also use the present embodiment as follows
Method is made：
Purslane extract is prepared by following technique：Take purslane to dry, surpassed using 95% ethanol as entrainment reagent, CO2
Critical extraction, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；After supercritical extract
Residue, enzyme hydrolysis, extracting in water, filtering, extract solution addition activated carbon and carclazyte are carried out, is centrifuged, is concentrated and dried, obtains extract
B；Extract A and extract B are well mixed, obtain purslane extract.
Phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, extracted using supercritical fluid CO 2
Method is taken, and is dispersed in water by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried, using macroporous absorbent resin dynamic
Absorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, absorption
After the completion of eluted with ethanol solution, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Dendrobium candidum extract is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then
60-90 mesh sieves are crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifuges 4500-
5500r/min removes slag, and then by supernatant concentration, is subsequently added into distilled water dissolving, then centrifuges 5- in 8000-12000r/min
15min, precipitation is dried to obtain dendrobium candidum extract.
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, and the percentage by weight of feed components is：Purslane is extracted
Thing 10%, phllostachys pubescens leaf ext 30%, dendrobium candidum extract 20%, kuh-seng root extract 5%, licorice root extract 8%, honeysuckle flowers
Extract 10%, oat extract 5% and auxiliary material 12%, wherein auxiliary material are the mixture of propane diols 4.8% and glycerine 7.2%.
A kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, comprises the following steps：By auxiliary material and oat
Extract is stirred, and is warming up to 70-75 DEG C, is stirred to component and is completely dissolved, and then stirring is cooled to 30-40 DEG C, then according to
Secondary addition purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then into mixture according to
Secondary addition licorice root extract, honeysuckle flower extract and kuh-seng root extract, stir, ultrasonic 0.5-1 hours, obtain into
Product.
Embodiment 4
One kind provided by the invention has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, raw materials used medicine：Purslane extract, mao bamboon
It is prepared by leaf extract, dendrobium candidum extract, kuh-seng root extract, licorice root extract, honeysuckle flower extract, oat extract
Method is：Using purslane, Moso Bamboo Leaves, dendrobium candidum, radix sophorae, licorice, honeysuckle flowers, oat raw material respectively with 95% ethanol
Derect seething, each extract is then condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower respectively and carry
Take thing, Egyptian blue water lily flower extract, little Cassia tora seed extract.Auxiliary material includes propane diols and glycerine can be bought by market.
Wherein, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract can also use the present embodiment as follows
Method is made：
Purslane extract is prepared by following technique：Take purslane to dry, surpassed using 95% ethanol as entrainment reagent, CO2
Critical extraction, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；After supercritical extract
Residue, enzyme hydrolysis, extracting in water, filtering, extract solution addition activated carbon and carclazyte are carried out, is centrifuged, is concentrated and dried, obtains extract
B；Extract A and extract B are well mixed, obtain purslane extract.
Phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, extracted using supercritical fluid CO 2
Method is taken, and is dispersed in water by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried, using macroporous absorbent resin dynamic
Absorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, absorption
After the completion of eluted with ethanol solution, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Dendrobium candidum extract is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then
60-90 mesh sieves are crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifuges 4500-
5500r/min removes slag, and then by supernatant concentration, is subsequently added into distilled water dissolving, then centrifuges 5- in 8000-12000r/min
15min, precipitation is dried to obtain dendrobium candidum extract.
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, and the percentage by weight of feed components is：Purslane is extracted
Thing 1%, phllostachys pubescens leaf ext 30%, dendrobium candidum extract 15%, kuh-seng root extract 10%, licorice root extract 10%, honeysuckle flowers
Extract 1%, oat extract 10% and auxiliary material 23%, wherein auxiliary material are the mixture of propane diols 9.2% and glycerine 13.8%.
A kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, comprises the following steps：By auxiliary material and oat
Extract is stirred, and is warming up to 70-75 DEG C, is stirred to component and is completely dissolved, and then stirring is cooled to 30-40 DEG C, then according to
Secondary addition purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then into mixture according to
Secondary addition licorice root extract, honeysuckle flower extract and kuh-seng root extract, stir, ultrasonic 0.5-1 hours, obtain into
Product.
Embodiment 5
One kind provided by the invention has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, raw materials used medicine：Purslane extract, mao bamboon
It is prepared by leaf extract, dendrobium candidum extract, kuh-seng root extract, licorice root extract, honeysuckle flower extract, oat extract
Method is：Using purslane, Moso Bamboo Leaves, dendrobium candidum, radix sophorae, licorice, honeysuckle flowers, oat raw material respectively with 95% ethanol
Derect seething, each extract is then condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower respectively and carry
Take thing, Egyptian blue water lily flower extract, little Cassia tora seed extract.Auxiliary material includes propane diols and glycerine can be bought by market.
Wherein, purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract can also use the present embodiment as follows
Method is made：
Purslane extract is prepared by following technique：Take purslane to dry, surpassed using 95% ethanol as entrainment reagent, CO2
Critical extraction, extract add 1,3-BDO, and organic layer reclaim reagent is dried to obtain extract A to the greatest extent；After supercritical extract
Residue, enzyme hydrolysis, extracting in water, filtering, extract solution addition activated carbon and carclazyte are carried out, is centrifuged, is concentrated and dried, obtains extract
B；Extract A and extract B are well mixed, obtain purslane extract.
Phllostachys pubescens leaf ext is prepared by following technique：Dry Moso Bamboo Leaves are crushed, extracted using supercritical fluid CO 2
Method is taken, and is dispersed in water by the use of absolute ethyl alcohol as agent, the extract for parsing to obtain is carried, using macroporous absorbent resin dynamic
Absorption, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, absorption
After the completion of eluted with ethanol solution, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Dendrobium candidum extract is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then
60-90 mesh sieves are crushed, then plus water carries out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifuges 4500-
5500r/min removes slag, and then by supernatant concentration, is subsequently added into distilled water dissolving, then centrifuges 5- in 8000-12000r/min
15min, precipitation is dried to obtain dendrobium candidum extract.
One kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, and the percentage by weight of feed components is：Purslane is extracted
Thing 1%, phllostachys pubescens leaf ext 25%, dendrobium candidum extract 30%, kuh-seng root extract 10%, licorice root extract 5%, honeysuckle flowers
Extract 1%, oat extract 6% and auxiliary material 22%, wherein auxiliary material are the mixture of propane diols 8.8% and glycerine 13.2%.
A kind of preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation, comprises the following steps：By auxiliary material and oat
Extract is stirred, and is warming up to 70-75 DEG C, is stirred to component and is completely dissolved, and then stirring is cooled to 30-40 DEG C, then according to
Secondary addition purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then into mixture according to
Secondary addition licorice root extract, honeysuckle flower extract and kuh-seng root extract, stir, ultrasonic 0.5-1 hours, obtain into
Product.
Clinical trial of the present invention and result
Experiment one：
Clinical observation 100 is carried out using example 1, skin clinic is mainly shown as skin inflammation before observation, and sensitive, itch is not
It is suitable, the long-term breaking-out having.
1st, method：After daily face cleaning, the compound formulation that on skin and easily prepared by hair position smearing embodiment 1 is appropriate, early
Evening is each once.3 days, 7 days, 1 month, statistical result.
2nd, judgment criteria：(1) cure：Clinical symptom disappearance, reacted again without skin sensitivity in one month；(2) effectively：Face
Bed symptom mitigation, skin sensitivity reactive moieties disappear or disappeared, and reduce or reduce；(3) it is invalid：Clinical symptoms, skin sensitivity are not
Get better and turn.
3rd, result on trial：(1) it is quick, 3 days, 7 days efficient reachable more than 90%, and have certain cure rate, 1
The cure rate of individual month is more than 85%.(2) it is notable to the general sensitivity treatment effect of skin.(3) occur without a reaction
Phenomena such as allergy, skin discomfort.
Experiment two：
Clinical observation 100 is carried out using example 2, skin clinic is mainly shown as skin inflammation before observation, and sensitive, itch is not
It is suitable, the long-term breaking-out having.
1st, method：After daily face cleaning, the compound formulation that on skin and easily prepared by hair position smearing embodiment 2 is appropriate, early
Evening is each once.3 days, 7 days, 1 month, statistical result.
2nd, judgment criteria：(1) cure：Clinical symptom disappearance, reacted again without skin sensitivity in one month；(2) effectively：Face
Bed symptom mitigation, skin sensitivity reactive moieties disappear or disappeared, and reduce or reduce；(3) it is invalid：Clinical symptoms, skin sensitivity are not
Get better and turn.
3rd, result on trial：(1) it is quick, 3 days, 7 days efficient reachable more than 95%, and have certain cure rate, 1
The cure rate of individual month is more than 85%.(2) it is notable to the general sensitivity treatment effect of skin.(3) occur without a reaction
Phenomena such as allergy, skin discomfort.
Experiment three：
Clinical observation 100 is carried out using example 3, skin clinic is mainly shown as skin inflammation before observation, and sensitive, itch is not
It is suitable, the long-term breaking-out having.
1st, method：After daily face cleaning, the compound formulation that on skin and easily prepared by hair position smearing embodiment 3 is appropriate, early
Evening is each once.3 days, 7 days, 1 month, statistical result.
2nd, judgment criteria：(1) cure：Clinical symptom disappearance, reacted again without skin sensitivity in one month；(2) effectively：Face
Bed symptom mitigation, skin sensitivity reactive moieties disappear or disappeared, and reduce or reduce；(3) it is invalid：Clinical symptoms, skin sensitivity are not
Get better and turn.
3rd, result on trial：(1) it is quick, 3 days, 7 days efficient reachable more than 87%, and have certain cure rate, 1
The cure rate of individual month is more than 80%.(2) it is notable to the general sensitivity treatment effect of skin.(3) occur without a reaction
Phenomena such as allergy, skin discomfort.
Experiment four：
Clinical observation 100 is carried out using example 4, skin clinic is mainly shown as skin inflammation before observation, and sensitive, itch is not
It is suitable, the long-term breaking-out having.
1st, method：After daily face cleaning, the compound formulation that on skin and easily prepared by hair position smearing embodiment 4 is appropriate, early
Evening is each once.3 days, 7 days, 1 month, statistical result.
2nd, judgment criteria：(1) cure：Clinical symptom disappearance, reacted again without skin sensitivity in one month；(2) effectively：Face
Bed symptom mitigation, skin sensitivity reactive moieties disappear or disappeared, and reduce or reduce；(3) it is invalid：Clinical symptoms, skin sensitivity are not
Get better and turn.
3rd, result on trial：(1) it is quick, 3 days, 7 days efficient reachable more than 92%, and have certain cure rate, 1
The cure rate of individual month is more than 83%.(2) it is notable to the general sensitivity treatment effect of skin.(3) occur without a reaction
Phenomena such as allergy, skin discomfort.
Experiment five：
Clinical observation 100 is carried out using example 5, skin clinic is mainly shown as skin inflammation before observation, and sensitive, itch is not
It is suitable, the long-term breaking-out having.
1st, method：After daily face cleaning, the compound formulation that on skin and easily prepared by hair position smearing embodiment 5 is appropriate, early
Evening is each once.3 days, 7 days, 1 month, statistical result.
2nd, judgment criteria：(1) cure：Clinical symptom disappearance, reacted again without skin sensitivity in one month；(2) effectively：Face
Bed symptom mitigation, skin sensitivity reactive moieties disappear or disappeared, and reduce or reduce；(3) it is invalid：Clinical symptoms, skin sensitivity are not
Get better and turn.
3rd, result on trial：(1) it is quick, 3 days, 7 days efficient reachable more than 95%, and have certain cure rate, 1
The cure rate of individual month is more than 86%.(2) it is notable to the general sensitivity treatment effect of skin.(3) occur without a reaction
Phenomena such as allergy, skin discomfort.
The technical concepts and features of embodiment of above only to illustrate the invention, its object is to allow be familiar with technique
People understands present disclosure and is carried out, and it is not intended to limit the scope of the present invention, all according to spirit of the invention
The equivalent change or modification that essence is done, it should all cover within the scope of the present invention.
Claims (9)
1. one kind has anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：The percentage by weight of feed components is：Horse
Sativa extract 1-10%, phllostachys pubescens leaf ext 20-30%, dendrobium candidum extract 1-30%, kuh-seng root extract 1-10%, radix glycyrrhizae
Root extract 1-10%, honeysuckle flower extract 1-10%, oat extract 1-10% and surplus auxiliary material.
2. according to claim 1 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：Feed components
Percentage by weight is：Purslane extract 5-10%, phllostachys pubescens leaf ext 20-30%, dendrobium candidum extract 10-20%, radix sophorae
Extract 2-5%, licorice root extract 3-8%, honeysuckle flower extract 5-10%, oat extract 2-5% and surplus auxiliary material.
3. according to claim 1 or 2 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：Auxiliary material is guarantor
Humectant, the NMF are the mixture of propane diols and glycerine.
4. according to claim 3 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation product, it is characterised in that the NMF
Middle propane diols and glycerine are 1 according to weight ratio:1.5 mixing.
5. according to claim 1 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：Purslane extract
Prepared by following technique：Take purslane to dry, added using 95% ethanol as entrainment reagent, CO2 supercritical extracts, extract
Enter 1,3-BDO, organic layer reclaim reagent is dried to obtain extract A to the greatest extent；Residue after supercritical extract, enzyme hydrolysis is carried out,
Extracting in water, filtering, extract solution add activated carbon and carclazyte, centrifuge, and are concentrated and dried, obtain extract B；By extract A and carry
Take thing B to be well mixed, obtain purslane extract.
6. according to claim 1 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：Phllostachys pubescens leaf ext
Prepared by following technique：Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and use absolute ethyl alcohol
As agent is carried, the extract for parsing to obtain is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, second is used after the completion of absorption
Alcoholic solution is eluted, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is washed after the completion of absorption with ethanol solution
De-, eluent is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
7. according to claim 1 have anti-inflammatory antiallergic itching-relieving efficacies compound formulation, it is characterised in that：Dendrobium candidum extracts
Thing is prepared by following technique：Dendrobium candidum is dried in vacuo 1-3h in 50-70 DEG C, then crushed 60-90 mesh sieves, then
Water is added to carry out ultrasound bath heating extraction, ultrasonic power 280-320W, centrifugation 4500-5500r/min removes slag, then by supernatant
Liquid concentrates, and is subsequently added into distilled water dissolving, then centrifuges 5-15min in 8000-12000r/min, precipitation is dried to obtain into iron sheet
Herba Dendrobii extract.
A kind of 8. preparation method with anti-inflammatory antiallergic itching-relieving efficacies compound formulation described in claim 1, it is characterised in that：Will
Auxiliary material and oat extract are stirred, and are warming up to 70-75 DEG C, are stirred to component and are completely dissolved, and then stirring is cooled to 30-
40 DEG C, sequentially add purslane extract, phllostachys pubescens leaf ext and dendrobium candidum extract, ultrasonic 0.5-1 hours, then to mixed
Licorice root extract, honeysuckle flower extract and kuh-seng root extract are sequentially added in compound, is stirred, ultrasonic 0.5-1 hours,
Obtain finished product.
A kind of 9. application with anti-inflammatory antiallergic itching-relieving efficacies compound formulation described in claim 1 or 2, it is characterised in that：Institute
That states has anti-inflammatory antiallergic itching-relieving efficacies compound formulation as cosmetics, the functional additive of the antianaphylactic medicine of commodity.
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| CN108272689A (en) * | 2018-03-31 | 2018-07-13 | 佛山文森特知识产权服务有限公司 | A kind of skin care compositions of Shu Min skin cares and its application |
| CN109045248A (en) * | 2018-10-27 | 2018-12-21 | 湖南慧好生物医药科技有限公司 | A kind of Chinese yew compound preparation and preparation method thereof and purposes |
| CN109045247A (en) * | 2018-10-27 | 2018-12-21 | 湖南慧好生物医药科技有限公司 | A kind of dendrobium candidum compound preparation and preparation method thereof and purposes |
| CN109125224A (en) * | 2018-10-30 | 2019-01-04 | 广州市尚昇生物科技有限公司 | A kind of antiallergic repairs water and preparation method thereof |
| CN109464328A (en) * | 2018-11-27 | 2019-03-15 | 南通优护优家卫生用品有限公司 | Plant type bacterio static itching-relieving liquid |
| CN109662899A (en) * | 2019-01-07 | 2019-04-23 | 珠海中科先进技术研究院有限公司 | A kind of application of matrine gallate in cosmetics and preparation method thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN110101642A (en) * | 2019-06-21 | 2019-08-09 | 广州市澳源科技集团有限公司 | A kind of antiallergic takes off red composition, preparation method and skin care |
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| CN112618475A (en) * | 2021-01-22 | 2021-04-09 | 上海加新生物科技有限公司 | Anti-inflammatory, anti-allergic and itching-relieving plant composition and preparation method and application thereof |
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| CN109045248A (en) * | 2018-10-27 | 2018-12-21 | 湖南慧好生物医药科技有限公司 | A kind of Chinese yew compound preparation and preparation method thereof and purposes |
| CN109045247A (en) * | 2018-10-27 | 2018-12-21 | 湖南慧好生物医药科技有限公司 | A kind of dendrobium candidum compound preparation and preparation method thereof and purposes |
| CN109125224A (en) * | 2018-10-30 | 2019-01-04 | 广州市尚昇生物科技有限公司 | A kind of antiallergic repairs water and preparation method thereof |
| CN109464328A (en) * | 2018-11-27 | 2019-03-15 | 南通优护优家卫生用品有限公司 | Plant type bacterio static itching-relieving liquid |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN109662899A (en) * | 2019-01-07 | 2019-04-23 | 珠海中科先进技术研究院有限公司 | A kind of application of matrine gallate in cosmetics and preparation method thereof |
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| CN111214405A (en) * | 2020-01-22 | 2020-06-02 | 四川万物本草健康科技有限公司 | Radix sophorae flavescentis after-sun repair care stock solution and application thereof in skin care product |
| CN112618475A (en) * | 2021-01-22 | 2021-04-09 | 上海加新生物科技有限公司 | Anti-inflammatory, anti-allergic and itching-relieving plant composition and preparation method and application thereof |
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Application publication date: 20180323 |