CN113713018A

CN113713018A - Traditional Chinese medicine composition of eczema ointment and preparation process thereof

Info

Publication number: CN113713018A
Application number: CN202111199498.5A
Authority: CN
Inventors: 吕向东
Original assignee: Zhejiang Yanghe Health Management Technology Co ltd
Current assignee: Zhejiang Yanghe Health Management Technology Co ltd
Priority date: 2021-10-14
Filing date: 2021-10-14
Publication date: 2021-11-30

Abstract

The invention provides a traditional Chinese medicine composition of eczema ointment and a preparation process thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition of the eczema ointment comprises the following components in parts by weight: herba Portulacae, herba Artemisiae Annuae, fructus Zanthoxyli, herba Menthae, radix Gentianae, fructus Cnidii, radix Sophorae Flavescentis, radix Cynanchi Paniculati, flos Chrysanthemi, Coptidis rhizoma, cortex Phellodendri, flos Lonicerae, radix Sangusorbae, radix Arnebiae and herba Taraxaci. The traditional Chinese medicine composition of the eczema ointment has mild medicine properties, has small irritation to human skin, has a good treatment effect on eczema of patients, has a good effect of treating itching and pain, and avoids secondary infection and other situations caused by scratching of patients. In addition, the invention also provides a preparation process of the traditional Chinese medicine composition of the eczema ointment, which is characterized in that effective components of all components in the composition are fully extracted by a reflux extraction method to prepare the external ointment, and the treatment effect on eczema can be improved.

Description

Traditional Chinese medicine composition of eczema ointment and preparation process thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition of eczema ointment and a preparation process thereof.

Background

Eczema is a skin inflammatory reaction with intense pruritus caused by various internal and external factors. It is divided into three stages of acute stage, subacute stage and chronic stage. The acute stage is prone to exudation, while the chronic stage is infiltrative and hypertrophic. Some patients directly manifest chronic eczema. The skin lesion has the characteristics of polymorphism, symmetry, pruritus, easy repeated attack and the like. Chronic eczema is often transformed into chronic eczema due to the recurrent attack of acute eczema and subacute eczema; chronic eczema may also begin. It is manifested as thickening, infiltration, reddish brown or pigmentation of the affected skin, rough surface, scaling, or scabbing due to scratching. The subjective itching was intense. It is commonly seen in the lower leg, hand, foot, elbow, popliteal fossa, vulva, anus, etc. The disease course is indefinite, the disease is easy to recur and the disease is not cured for a long time. At present, clinically, miconazole ointment and the like are externally used for treating eczema, and ciprofloxacin ointment and the like are also externally used for treating eczema. The clinical ointment has a single treatment range, multiple ointments are often required for combined treatment, the use is troublesome, some existing medicines have strong medicinal properties, great irritation to skin and poor treatment effect, and patients still suffer from advanced infection and other conditions caused by itching and pain and scratching at the eczema.

Disclosure of Invention

The invention aims to provide the traditional Chinese medicine composition of the eczema ointment, which has mild medicine property, less stimulation to human skin, better eczema treatment effect on patients, good itch and pain treatment effect and capability of avoiding secondary infection and the like caused by scratching of the patients.

The invention also aims to provide a preparation process of the traditional Chinese medicine composition of the eczema ointment, which is characterized in that effective components of all components in the composition are fully extracted by a reflux extraction method to prepare the external ointment, so that the treatment effect on eczema can be improved.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight:

30-40 parts of purslane, 5-15 parts of artemisia annua, 5-15 parts of pepper, 10-20 parts of mint, 10-20 parts of gentian, 10-20 parts of fructus cnidii, 10-20 parts of radix sophorae flavescentis, 3-12 parts of cynanchum paniculatum, 5-10 parts of chrysanthemum, 10-15 parts of coptis chinensis, 3-12 parts of golden cypress, 10-30 parts of honeysuckle, 10-15 parts of garden burnet, 10-15 parts of lithospermum and 10-15 parts of dandelion.

In some embodiments of the present invention, the aloe gel further comprises 20 to 30 parts by weight of aloe gel, 5 to 10 parts by weight of collagen, and 0.1 to 2 parts by weight of hyaluronic acid.

In some embodiments of the present invention, the apple vinegar further comprises 10-20 parts by weight of apple vinegar.

In some embodiments of the present invention, the composition further comprises 30-50 parts of coconut oil and 0.1-2 parts of maritime pine bark extract.

On the other hand, the embodiment of the application provides a preparation process of a traditional Chinese medicine composition of eczema ointment, which comprises the following steps:

mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract;

mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound;

mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with ethanol solution to obtain ethanol extractive solution, recovering ethanol from the ethanol extractive solution, and concentrating the ethanol extractive solution to obtain ethanol extract;

mixing the ultrasonic extract, the volatile oil clathrate and the ethanol extract to obtain a mixture, adding a thickening agent, and stirring to obtain an ointment.

In some embodiments of the present invention, the volume concentration of the ethanol solution is 50 to 90%.

In some embodiments of the present invention, the ethanol extract from which ethanol is recovered is concentrated until the relative density of the ethanol extract is 0.85 to 1.01.

In some embodiments of the present invention, the temperature of the heating reflux extraction is 50 to 70 ℃, the time of the heating reflux extraction is 2 to 5 hours, and the number of times of the heating reflux extraction is 2 to 3 times.

In some embodiments of the present invention, the thickener comprises 0.01 to 2.0 parts by weight of gum arabic, 0.01 to 4.0 parts by weight of pectin, 0.01 to 2.0 parts by weight of agar, and 0.01 to 2.0 parts by weight of agar.

In some embodiments of the present invention, 0.5 to 2 parts by weight of a natural preservative is added to the mixture during the stirring, and the natural preservative is sandalwood leaf flavone.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight:

The purslane contains a lot of organic acids, tannins and other components, has a certain astringing and calming effect, can relieve the symptoms of pruritus at the eczema part, and meanwhile, vitamins and carotene contained in the purslane can increase the skin resistance. The purslane also contains a novel alkaloid, has an obvious anti-inflammatory effect, can be quickly distributed on the affected part of a patient, has high utilization rate, and can be used as a lead compound of eczema. In addition, the purslane can also extract an isoindole alkaloid which can inhibit the generation of NO in mononuclear macrophage leukemia cells (RAw 264.7.7) induced by LPS, and the remarkable anti-inflammatory effect is proved. The artemisia annua has the effects of relieving fever, tranquilizing, relieving itching and resisting bacteria, can inhibit bacteria at the eczema of a patient from breeding, can better calm, relieve itching and avoid scratching of the patient, and can avoid secondary infection. Similarly, the volatile oil substance of the pepper can inhibit various bacteria and also can play a role in tranquilizing and relieving itching; the extract such as oleum Menthae Dementholatum has effects of inhibiting various bacteria, resisting inflammation, and relieving itching; the radix Gentianae has effects of inhibiting multiple bacteria and relieving itching of eczema; the radix Sophorae Flavescentis has antiinflammatory, analgesic, antipruritic and antibacterial effects, and matrine and oxymatrine are the main alkaloids components in radix Sophorae Flavescentis, and have antiinflammatory, analgesic and antipruritic effects; the fructus Cnidii also has antiinflammatory, antiviral and antipruritic effects; said Cynanchum paniculatum has anti-inflammatory, antiviral and antipruritic effects. The purslane is used as a monarch drug, and the artemisia annua, the pepper, the mint, the gentian, the radix sophorae flavescentis, the fructus cnidii and the paniculate swallowwort root are used as ministerial drugs, so that the effect of treating eczema can be improved by assisting the purslane, the itching relieving function can be greatly improved, and secondary infection and other situations caused by scratching of patients can be prevented. Meanwhile, the chrysanthemum has the antibacterial and anti-inflammatory effects, and the coptis chinensis has the antibacterial and anti-inflammatory effects; the phellodendron bark also has the effects of bacteriostasis, anti-inflammation and antifungal combination; the flos Lonicerae also has antibacterial and antiinflammatory effects; the radix Sangusorbae has antiinflammatory, repercussive, antibacterial and hemostatic effects; the radix Arnebiae has antibacterial and antiinflammatory effects; the herba Taraxaci also has antibacterial and antiinflammatory effects. The chrysanthemum, the coptis chinensis, the golden cypress, the honeysuckle, the garden burnet, the lithospermum and the dandelion, adjuvant and purslane can improve the anti-inflammatory and antibacterial effects and the treatment effect on eczema, and in mutual drug properties of the ministerial drugs, the drug properties are relatively mild and less irritant to human skin.

Therefore, the traditional Chinese medicine composition of the eczema ointment has mild medicinal properties, has small irritation to human skin, has good treatment effect on eczema of patients, has good effect of treating itching and pain, and avoids secondary infection and the like caused by scratching of patients.

The invention also provides a preparation process of the traditional Chinese medicine composition of the eczema ointment, which comprises the following steps:

mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with ethanol solution to obtain ethanol extract, recovering ethanol from the ethanol extract to obtain purified solution, and concentrating the purified solution to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil clathrate and the ethanol extract to obtain a mixture, adding a thickening agent, and stirring to obtain an ointment.

The preparation process of the traditional Chinese medicine composition of the eczema ointment fully extracts the effective components of all the components in the composition by a reflux extraction method to prepare the external ointment, and the treatment effect on eczema can be improved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The invention provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 30-40 parts of purslane, 5-15 parts of artemisia annua, 5-15 parts of pepper, 10-20 parts of mint, 10-20 parts of gentian, 10-20 parts of fructus cnidii, 10-20 parts of radix sophorae flavescentis, 3-12 parts of cynanchum paniculatum, 5-10 parts of chrysanthemum, 10-15 parts of coptis chinensis, 3-12 parts of golden cypress, 10-30 parts of honeysuckle, 10-15 parts of garden burnet, 10-15 parts of lithospermum and 10-15 parts of dandelion.

The purslane contains a lot of organic acids, tannins and other components, has a certain astringing and calming effect, can relieve the symptoms of pruritus at the eczema part, and meanwhile, vitamins and carotene contained in the purslane can increase the skin resistance. The purslane also contains a novel alkaloid, has an obvious anti-inflammatory effect, can be quickly distributed on the affected part of a patient, has high utilization rate, and can be used as a lead compound of eczema. In addition, the purslane can also extract an isoindole alkaloid which can inhibit the generation of NO in mononuclear macrophage leukemia cells (RAw 264.7.7) induced by LPS, and the remarkable anti-inflammatory effect is proved. The artemisia annua has the effects of relieving fever, tranquilizing, relieving itching and resisting bacteria, can inhibit bacteria at the eczema part of a patient from breeding, and can better calm, relieve itching and avoid scratching of the patient to cause secondary infection. Similarly, the volatile oil substance of the pepper can inhibit various bacteria and also can play a role in tranquilizing and relieving itching; the extract such as oleum Menthae Dementholatum has effects of inhibiting various bacteria, resisting inflammation, and relieving itching; the radix Gentianae has effects of inhibiting multiple bacteria and relieving itching of eczema; the radix Sophorae Flavescentis has antiinflammatory, analgesic, antipruritic and antibacterial effects, and matrine and oxymatrine are the main alkaloids components in radix Sophorae Flavescentis, and have antiinflammatory, analgesic and antipruritic effects; the fructus Cnidii also has antiinflammatory, antiviral and antipruritic effects; said Cynanchum paniculatum has anti-inflammatory, antiviral and antipruritic effects. The purslane is used as a monarch drug, and the artemisia annua, the pepper, the mint, the gentian, the radix sophorae flavescentis, the fructus cnidii and the paniculate swallowwort root are used as ministerial drugs, so that the effect of treating eczema can be improved by assisting the purslane, the itching relieving function can be improved, and secondary infection and other situations caused by scratching of patients can be prevented. Meanwhile, the chrysanthemum has the antibacterial and anti-inflammatory effects, and the coptis chinensis has the antibacterial and anti-inflammatory effects; the phellodendron bark also has the effects of bacteriostasis, anti-inflammation and antifungal combination; the flos Lonicerae also has antibacterial and antiinflammatory effects; the radix Sangusorbae has antiinflammatory, repercussive, antibacterial and hemostatic effects; the radix Arnebiae has antibacterial and antiinflammatory effects; the herba Taraxaci also has antibacterial and antiinflammatory effects. The chrysanthemum, the coptis chinensis, the golden cypress, the honeysuckle, the garden burnet, the lithospermum and the dandelion, as well as the adjuvant and the purslane can improve the anti-inflammatory and antibacterial effects and the treatment effect on eczema, and the ministerial drugs are mild and have less irritation to human skin after being neutralized.

The purslane can obviously inhibit gram-negative bacteria such as shigella, escherichia coli, klebsiella, citrobacter and the like, and the flavone substances in the purslane have the same antibacterial effect and have stronger inhibitory effect on bacillus subtilis, staphylococcus aureus and the like, and the antibacterial mechanism is mainly to destroy bacterial cell membranes and enable intracellular substances to ooze out so as to realize the antibacterial effect. The polysaccharide substance in the purslane can also obviously inhibit staphylococcus aureus, dysentery bacillus and escherichia coli, and has the strongest effect on the dysentery bacillus. The purslane polysaccharide has obvious inhibitory activity on acute and chronic inflammatory eczema patients, and simultaneously shows strong analgesic and antipruritic activities. The purslane polysaccharide can increase the level of anti-inflammatory cytokines IL-10 and reduce the levels of proinflammatory cytokines TNF-alpha and IL-6, thereby playing an anti-inflammatory treatment role on eczema.

The herba Artemisiae Annuae contains volatile oil, artemisinin, artesunic lactone, alpha-pinene, camphor, oleanolic acid, artemisone, and flavonoid, and 5% extract of herba Artemisiae Annuae has effect in inhibiting superficial fungi. The oleum Artemisiae Annuae and liniment have in vitro antibacterial effect on Trichophyton rubrum and Trichophyton floccosum, Trichophyton cerebri, Microsporum gypseum, Trichophyton dermatitis, Pepper's chromobacterium, Sporomyces, Candida albicans, and Cryptococcus neoformans. The artemisia annua extract has the functions of dispelling wind, arresting itching, clearing heat and drying dampness by external application, and can obviously play a role in resisting inflammation.

The pepper contains abundant chemical components, and is researched more by volatile oil, amides and alkaloids. The volatile oil of fructus Zanthoxyli has antioxidant, antibacterial, insecticidal, antiinflammatory, analgesic, and local anesthetic effects. The volatile oil of the pepper has good bacteriostatic action, the polarity of the components of the volatile oil is inseparable from the bacteriostatic action, a sample with relatively low polarity has good effect on fungi, and a sample with relatively high polarity has obvious effect on bacteria. The volatile oil of the pepper has better inhibition effect on gram-negative bacteria and gram-positive bacteria, and has more obvious effect on penicillium and aspergillus niger.

The chemical components of herba Menthae mainly include volatile components and nonvolatile components. The volatile components mainly include oleum Menthae Dementholatum, menthol, etc. The non-volatile components are identified to include steroids, flavonoids, triterpenic acids, phenolic acids and the like. The peppermint oil extract of peppermint has obvious anti-inflammatory effect, and meanwhile, flavonoid components in the peppermint also have high anti-inflammatory effect, and fruit acid substances in the peppermint also have anti-inflammatory effect. Menthol in mint has the effects of resisting inflammation and bacteria, and can relieve discomfort of a patient by generating strong cooling feeling on the eczema skin of the patient to achieve the effect of relieving itching.

The gentisic in the radix Gentianae can be refined to achieve tranquilizing and itching relieving effects, and also has antiinflammatory and antibacterial effects. The extract of radix Gentianae can be used for treating tinea pedis and skin pruritus.

The fructus Cnidii extract has antibacterial effect on ureaplasma urealyticum in vitro, and total coumarin in fructus Cnidii can significantly reduce pathogenicity of Staphylococcus aureus residual strain. Meanwhile, the effective components of the fructus cnidii for relieving itching are alcohol extract and volatile oil thereof. Its antipruritic mechanism is associated with the release of antagonistic histamine; the fructus cnidii effective component can remarkably improve the itch threshold of histamine phosphate to eczema patients, remarkably inhibit skin itch reaction caused by 4-aminopyridine, inhibit histamine release of mast cells in skin tissues and remarkably resist skin allergic reaction.

In the radix sophorae flavescentis, matrine and oxymatrine are the most main alkaloid components in the radix sophorae flavescentis, and have obvious anti-inflammatory and analgesic effects. Meanwhile, the bacteriostatic effect of flavonoids in the sophora flavescens is also obvious.

The radix Cynanchi Paniculati has effects of dispelling pathogenic wind, eliminating dampness, relieving pain and itching, and the polysaccharide component and paeonol component in radix Cynanchi Paniculati can resist immunity molecule, resist inflammation, and inhibit bacteria. The paeonol component in radix Cynanchi Paniculati has tranquilizing and antipruritic effects.

The chrysanthemum has obvious sterilization and antibacterial effects, particularly the chrysanthemum morifolium has obvious antibacterial effect, and the suppression rate of the chrysanthemum morifolium on bacteria is close to 100%. When the tubercle bacillus is in vivo, the chrysanthemum also has a certain suppression effect, so in clinical application, the chrysanthemum can also be used as an antibacterial agent. The chrysanthemum has obvious effects on protecting blood vessels, strengthening the resistance of the blood vessels and suppressing the permeability of the blood vessels. When the permeability of the capillary vessel is suppressed, the anti-inflammatory effect is naturally exhibited. In practical clinical application, chrysanthemum is also commonly used as an anti-inflammatory drug. Both flavonoids and bioactive substances in the chrysanthemum have very obvious antibacterial effect.

The coptis comprises alkaloids, lignans, flavonoids, acid components and the like, wherein the alkaloids are the main active ingredients. The coptis has broad-spectrum antibacterial activity, can obviously inhibit gram-positive bacteria (such as staphylococcus aureus, diplococcus pneumoniae and the like), gram-negative bacteria (such as escherichia coli, typhoid bacillus and the like) and fungi, and is difficult to generate drug resistance compared with common antibiotics. The alkaloid in the coptis root has obvious inhibition effect on acute and chronic inflammatory reactions.

The alkaloids of cortex Phellodendri are main components of cortex Phellodendri, and have content of above 3%, and mainly comprise small alkaloid type tetrahydroisoquinoline alkaloids such as hydrochloric acid trabecine, jateorhizine, palmatine, and tetrandrine. Cortex Phellodendri has wide application in dermatology, and has antiallergic, antioxidant and antibacterial effects.

The flos Lonicerae extract has effect in inhibiting pathogenic bacteria activity, and can promote inflammation control. In the related chronic and acute inflammation experiments, the honeysuckle aqueous solution has obvious effects on analgesia and inflammation diminishing.

The effective components of radix Sangusorbae are mostly concentrated in rhizome. The rhizome mainly contains tannin, phenolic acid, saponin, etc., and also contains a few organic acids, steroids, etc. The radix Sangusorbae extract has obvious anti-inflammatory effect on eczema patients.

The radix Arnebiae contains multiple naphthoquinone, polysaccharide, phenolic acid and esters, and liposoluble naphthoquinone pigment is one of the main active ingredients of radix Arnebiae, and has antiinflammatory and antibacterial effects.

The herba Taraxaci has high nutritive value, is rich in proteins, fatty acids, amino acids, vitamins and microelements, and also contains multiple effective components such as flavonoids, phenolic acids, sterols, polysaccharides, etc. The dandelion extract has obvious anti-inflammatory effect and bacteriostatic effect.

The chrysanthemum, the coptis chinensis, the golden cypress, the honeysuckle, the garden burnet, the lithospermum and the dandelion are used as ministerial drugs, can further improve the antibacterial and anti-inflammatory effects, can better play the antibacterial and anti-inflammatory effects when being matched with monarch drugs, and further worsens the skin diseases of eczema patients.

The traditional Chinese medicine composition of the eczema cream further comprises 20-30 parts by weight of aloe gel, 5-10 parts by weight of collagen and 0.1-2 parts by weight of hyaluronic acid. Aloe gel is juice (purified) obtained from succus of folium Aloe of Liliaceae, and mainly comprises aloe-emodin, aloe anthrone, various saccharides, enzymes, and amino acids. The liquid is light yellow green liquid, the relative density is 0.98-1.02, and the pH value is 4-6. The product is mainly used for skin and hair protection products in cosmetics, and has the effects of moisturizing, preventing sunburn, deodorizing, preventing obesity, softening skin, diminishing inflammation, relieving itching, relieving pain, preventing acne and freckle, fading mottle and the like. The aloe gel contains high nutritional ingredients, is mainly used in cosmetics, has strong permeability and remarkable moisturizing and water replenishing functions, and can decompose pigmentation to achieve the purpose of whitening. The skin of a common eczema patient can be damaged, the problems of scars, acne marks and the like can be easily caused after healing, and the aloe gel can be added to improve the skin, prevent the problems of the scars and the acne marks, whiten the skin and supplement moisture for the skin.

The collagen is extracted from animal skin, and the skin contains proteoglycan such as hyaluronic acid and chondroitin sulfate besides collagen, which contains a large amount of polar groups, is a moisturizing factor, and has the effect of preventing tyrosine in the skin from being converted into melanin, so the collagen has the effects of purely natural moisturizing, whitening, wrinkle resistance, freckle removal and the like. The skin care product has the advantages that the defect can be caused on the common surface of the eczema skin, so that the skin care product is not attractive after a patient is cured, and the collagen can play the effects of moisturizing, whitening, preventing wrinkles and removing freckles, so that the skin of the eczema patient is repaired.

The hyaluronic acid is a main component constituting connective tissues such as human intercellular substance, vitreous body, synovial fluid of joints, etc., and plays important physiological functions of retaining water, maintaining extracellular space, regulating osmotic pressure, lubricating and promoting cell repair in vivo.

Therefore, the aloe gel, the collagen and the hyaluronic acid are used in combination, so that the skin condition of the eczema patient can be improved, the skin defect problem of the eczema patient after treatment can be effectively prevented, and the skin is more attractive. Meanwhile, the aloe gel has the functions of diminishing inflammation, relieving itching and relieving pain, and can further improve the treatment effect on eczema by being matched with the compositions. In addition, the aloe gel, the collagen and the hyaluronic acid are combined to be used as adjuvant drugs and are matched with other compositions for use, so that the problem of eczema skin repair effect which cannot be solved by monarch drugs and ministerial drugs is solved, better body contact can be brought to patients, and the aloe gel, the collagen and the hyaluronic acid have soft feeling and moisturizing feeling and can bring better experience to the patients.

The traditional Chinese medicine composition of the eczema cream also comprises 10-20 parts of apple vinegar in parts by weight. The apple vinegar contains vitamins, inorganic salts, vitamins, enzymes, pectin and minerals (such as potassium, phosphorus, sulfur, iron, sodium and calcium), and can promote immune system and treat eczema. Beta-carotene is an antioxidant that helps to rejuvenate skin cells and eliminate dead cells. The apple vinegar has rich fiber content, and can improve digestive system to remove toxin in vivo and relieve eczema. The apple vinegar has astringent effect, and can eliminate bacteria, dust, oil and other impurities from entering skin. The apple vinegar has a greater source of potassium, which helps you get rid of eczema in the treatment of allergies. The above cider vinegar effectively balances the pH of the skin to prevent itching, dryness, pain and other discomfort due to eczema of the skin. The apple cider vinegar contains acetic acid, malic acid and lactic acid, and has antifungal effect, and can be used for preventing skin infection and eczema caused by dry skin.

Wherein the traditional Chinese medicine composition of the eczema ointment also comprises 30-50 parts of coconut oil and 0.1-2 parts of maritime pine bark extract. Coconut oil is rich in fatty acid, mainly comprises lauric acid, medium-chain fatty acid and other components, has excellent skin repairing effect, and has good treatment effect on eczema. Lauric acid is a fatty acid substance which can be converted into an antibacterial and antiviral substance in a human body, and coconut oil is an oil with a relatively low melting point. Is cool and can relieve the symptoms of skin redness and itching caused by allergy.

The antioxidant capacity of the pine bark extract is derived from procyanidin (procyanidin oligomer), which is 20 times that of vitamin C and 50 times that of vitamin E. Procyanidins, as a well-known antioxidant, can effectively suppress the action of free radicals which play an important role in degenerative diseases, cardiovascular diseases, blurred vision, sunburn and premature senility. Procyanidins are believed to protect the skin from damage by unwanted ultraviolet radiation and free radicals due to their antioxidant capacity. There is a great deal of evidence that procyanidins protect and strengthen collagen and elastin in the skin, thus preventing wrinkle formation and maintaining skin elasticity. The addition of procyanidins to a cream is a popular method of delaying skin aging, and theoretically, the skin can be rejuvenated to glow by repairing skin collagen and elastin. Meanwhile, since the free radicals play an important role in the process of tumor formation, procyanidins can be used in a proper amount to exert their anticancer effects. Meanwhile, proanthocyanidin has certain effects on various kinds of arthritis since it effectively inhibits inflammatory factors such as PG,5-HT, leukotrienes, etc., and selectively binds to connective voxels of joints to relieve pain and edema. The anti-allergic activity of procyanidins is believed to be a result of its anti-histamine activity. Compared with other antiallergic drugs, procyanidins have the same drug effect and do not have various side effects such as lethargy.

Therefore, the coconut oil and the maritime pine bark extract are used in combination, so that the repairing effect on the skin of the eczema patient can be achieved, the monarch drug and the ministerial drug are avoided, and the adjuvant drug effect is achieved. Meanwhile, the coconut oil and the maritime pine bark extract can be combined to be used as a ministerial drug, so that the anti-inflammatory and antibacterial effects are achieved, and the treatment effect of the monarch drug on eczema is improved.

weighing cortex phellodendri, purslane and felwort according to the weight parts, mixing and crushing the cortex phellodendri, the purslane and the felwort, heating, refluxing and extracting the mixture, and performing ultrasonic extraction to obtain an ultrasonic extract; weighing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root according to the parts by weight, mixing and crushing, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; weighing garden burnet root, pepper, lithospermum, honeysuckle, coptis root, chrysanthemum, radix sophorae flavescentis and fructus cnidii according to the parts by weight, mixing and crushing, and then extracting and purifying with ethanol: extracting with ethanol solution to obtain ethanol extract, recovering ethanol from the ethanol extract to obtain purified solution, and concentrating the purified solution to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding the aloe gel, the collagen and the hyaluronic acid, the collagen, the hyaluronic acid, the apple vinegar, the coconut oil and the maritime pine bark extract which are weighed according to the parts by weight into the mixture, adding the thickening agent, and stirring to obtain the ointment.

The preparation method of the Chinese medicinal composition of eczema ointment comprises extracting the effective components of the composition by reflux extraction to obtain topical ointment with improved therapeutic effect on eczema

Wherein the volume concentration of the ethanol solution is 50-90%.

Wherein, when the ethanol extract from which ethanol is recovered is concentrated, the ethanol extract is concentrated until the relative density of the ethanol extract is 0.85-1.01.

Wherein the thickener comprises 0.01-2.0 parts by weight of Arabic gum, 0.01-4.0 parts by weight of pectin, 0.01-2.0 parts by weight of agar and 0.01-2.0 parts by weight of agar. The thickening agent is a substance capable of increasing the viscosity of latex and liquid, and the gum arabic, the pectin, the agar and the agar have no harm to skin and can not cause damage to eczema skin.

Wherein the temperature of the heating reflux extraction is 50-70 ℃, the time of the heating reflux extraction is 2-5 hours, and the times of the heating reflux extraction are 2-3 times

Wherein, during the stirring, 0.5-2 parts by weight of natural preservative is added into the mixture. The natural preservative has the function of corrosion prevention, and the quality of the paste is prevented from being influenced by the breeding of bacteria.

Wherein the natural antiseptic is sandalwood leaf flavone.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 30g of purslane, 5g of artemisia annua, 5g of pepper, 10g of mint, 10g of gentian, 10g of fructus cnidii, 10g of radix sophorae flavescentis, 3g of cynanchum paniculatum, 5g of chrysanthemum, 10g of coptis chinensis, 3g of golden cypress, 10g of honeysuckle, 10g of sanguisorba officinalis, 10g of lithospermum and 10g of dandelion.

In the embodiment, the preparation process of the traditional Chinese medicine composition of the eczema ointment comprises the following steps: mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with 50% ethanol solution to obtain ethanol extractive solution, recovering ethanol, concentrating the ethanol extractive solution, and concentrating until the relative density of the ethanol extractive solution is 0.85 to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding a thickening agent, stirring to obtain a paste, and adding 0.5g of sandalwood leaf flavone while stirring. The thickener comprises the following components, by weight, 0.01g of gum arabic, 0.01g of pectin, 0.01g of agar and 0.01g of agar.

Mixing the ultrasonic extract, volatile oil clathrate and ethanol extract to obtain mixture, adding into the mixture, and adding thickener

Example 2

The embodiment provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 32g of purslane, 7g of artemisia annua, 7g of pepper, 12g of mint, 12g of gentian, 12g of fructus cnidii, 12g of radix sophorae flavescentis, 5g of cynanchum paniculatum, 6g of chrysanthemum, 12g of coptis chinensis, 5g of golden cypress, 14g of honeysuckle, 11g of sanguisorba, 11g of lithospermum and 11g of dandelion.

In the embodiment, the preparation process of the traditional Chinese medicine composition of the eczema ointment comprises the following steps: mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with 58% ethanol solution to obtain ethanol extractive solution, recovering ethanol, concentrating the ethanol extractive solution, and concentrating until the relative density of the ethanol extractive solution is 0.90 to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding a thickening agent, stirring to obtain a paste, and adding 0.9g of sandalwood leaf flavone while stirring. The thickener comprises the following components, by weight, 0.41g of gum arabic, 0.81g of pectin, 0.41 part of agar and 0.41g of agar.

Example 3

The embodiment provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 34g of purslane, 9g of artemisia annua, 9g of pepper, 14g of mint, 14g of gentian, 14g of fructus cnidii, 14g of radix sophorae flavescentis, 7g of cynanchum paniculatum, 7g of chrysanthemum, 12g of coptis chinensis, 7g of golden cypress, 18g of honeysuckle, 12g of sanguisorba officinalis, 12g of lithospermum and 12g of dandelion.

In the embodiment, the preparation process of the traditional Chinese medicine composition of the eczema ointment comprises the following steps: mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with 66% ethanol solution to obtain ethanol extractive solution, recovering ethanol, concentrating the ethanol extractive solution, and concentrating until the relative density of the ethanol extractive solution is 0.95 to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding a thickening agent, stirring to obtain a paste, and adding 1.3g of sandalwood leaf flavone while stirring. The thickener comprises the following components of 0.91g of gum arabic, 1.62g of pectin, 0.91g of agar and 0.91g of agar in parts by weight.

Example 4

The embodiment provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 36g of purslane, 11g of artemisia annua, 11g of pepper, 16g of mint, 16g of gentian, 16g of fructus cnidii, 16g of radix sophorae flavescentis, 11g of cynanchum paniculatum, 8g of chrysanthemum, 13g of coptis chinensis, 11g of golden cypress, 22g of honeysuckle, 13g of sanguisorba, 13g of lithospermum and 13g of dandelion.

In the embodiment, the preparation process of the traditional Chinese medicine composition of the eczema ointment comprises the following steps: mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting by adopting an ethanol solution with the volume concentration of 74% to obtain an ethanol extract, then recovering ethanol from the ethanol extract, concentrating the ethanol extract with the recovered ethanol until the relative density of the ethanol extract is 1.00, and obtaining the ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding a thickening agent, stirring to obtain a paste, and adding 1.4g of sandalwood leaf flavone while stirring. The thickener comprises the following components of 1.41g of gum arabic, 3.20g of pectin, 1.41g of agar and 1.41g of agar in parts by weight.

Example 5

The embodiment provides a traditional Chinese medicine composition of eczema ointment, which comprises the following components in parts by weight: 40g of purslane, 15g of artemisia annua, 15g of pepper, 20g of mint, 20g of gentian, 20g of fructus cnidii, 20g of radix sophorae flavescentis, 12g of cynanchum paniculatum, 10g of chrysanthemum, 15g of coptis chinensis, 12g of golden cypress, 30g of honeysuckle, 15g of sanguisorba, 15g of lithospermum and 15g of dandelion.

In the embodiment, the preparation process of the traditional Chinese medicine composition of the eczema ointment comprises the following steps: mixing and crushing phellodendron, purslane and gentian, heating, refluxing and extracting, and performing ultrasonic extraction to obtain an ultrasonic extract; mixing and crushing dandelion, chrysanthemum, artemisia annua, mint and paniculate swallowwort root, extracting volatile oil by using a steam distillation method, and adding beta-cyclodextrin for clathration to obtain a volatile oil clathrate compound; mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with 90% ethanol solution to obtain ethanol extract, recovering ethanol from the ethanol extract, concentrating the ethanol extract with recovered ethanol, and concentrating until the relative density of the ethanol extract is 1.01 to obtain ethanol extract; mixing the ultrasonic extract, the volatile oil inclusion compound and the ethanol extract to obtain a mixture, adding a thickening agent, stirring to obtain a paste, and adding 2g of sandalwood leaf flavone while stirring. The thickener comprises the following components of 2.0g of gum arabic, 4.0g of pectin, 2.0g of agar and 2.0g of agar in parts by weight.

Experimental example 1

70 volunteers with eczema are selected and divided into 7 groups, the numbers of the volunteers are 1-7 groups, 10 people in each group are selected, and 1-5 groups of volunteers correspondingly use the traditional Chinese medicine composition of the eczema ointment prepared by different parameters in the embodiments 1-5 to be smeared on the eczema for 30 days. The later 6-7 groups of volunteers applied two commercially available eczematous ointments (namely triamcinolone acetonide econazole cream and glucocorticoid cream, wherein the triamcinolone acetonide econazole cream is selected from the brand of paresone, and the glucocorticoid cream is selected from the brand of 999 dermatipide) to the eczematous area for 15 days. The dosage and the using time of the Chinese medicinal composition of the eczema ointment prepared by the volunteers according to different parameters are the same. The results of the volunteers in testing satisfaction rates (including the satisfaction rates of itching relieving effect, skin irritation and discomfort at the eczema, eczema healing degree and the like, wherein the satisfaction rates are obtained by scoring the volunteers and are divided into 0-100%, and the weighted average value of each group of volunteers is the average satisfaction rate of each group) are as follows:

TABLE 1 satisfaction rate table for volunteer trial

It can be observed from the above table that the overall satisfaction rate of 1-5 groups of volunteers is the best after the eczema volunteers use the traditional Chinese medicine composition of the eczema ointment prepared according to different parameters, and the overall satisfaction rate of 6-7 groups of corresponding volunteers is lower after the two types of ointment for treating eczema purchased from the market are used. In the column of satisfaction degree of antipruritic effect, it is obvious that the traditional Chinese medicine composition using the eczema ointment of the embodiment of the invention can achieve better antipruritic effect compared with the existing ointment for treating eczema on the market.

In the column of satisfaction degree of the eczema ointment for skin irritation and discomfort, compared with the existing ointment for treating eczema in the market, the traditional Chinese medicine composition using the eczema ointment provided by the embodiment of the invention has the advantages that the irritation and discomfort of the skin irritation and discomfort of the eczema are obviously weakened, and the traditional Chinese medicine composition of the eczema ointment provided by the embodiment of the invention is milder in treatment of the skin of a patient with eczema.

In the column of satisfaction degree of eczema healing degree, it is obvious that compared with the existing ointment for treating eczema on the market, the traditional Chinese medicine composition using the eczema ointment provided by the embodiment of the invention has higher eczema healing degree on the skin of an eczema part, and the traditional Chinese medicine composition of the eczema ointment provided by the embodiment of the invention has better treatment effect on the skin of an eczema patient. The traditional Chinese medicine composition of the eczema ointment has more reasons for causing eczema, the average satisfaction rate of the traditional Chinese medicine composition of the eczema ointment on the healing degree of eczema of the skin at the eczema is about 80%, and the traditional Chinese medicine composition of the eczema ointment has a better treatment effect on eczema patients.

In conclusion, the traditional Chinese medicine composition of the eczema ointment and the preparation process thereof are disclosed. The traditional Chinese medicine composition of the eczema ointment comprises the following components in parts by weight: 30-40 parts of purslane, 5-15 parts of artemisia annua, 5-15 parts of pepper, 10-20 parts of mint, 10-20 parts of gentian, 10-20 parts of fructus cnidii, 10-20 parts of radix sophorae flavescentis, 3-12 parts of cynanchum paniculatum, 5-10 parts of chrysanthemum, 10-15 parts of coptis chinensis, 3-12 parts of golden cypress, 10-30 parts of honeysuckle, 10-15 parts of garden burnet, 10-15 parts of lithospermum and 10-15 parts of dandelion. The traditional Chinese medicine composition of the eczema ointment has mild medicine properties, has small irritation to human skin, has a good treatment effect on eczema of patients, has a good effect of treating itching and pain, and avoids secondary infection and other situations caused by scratching of patients. In addition, the invention also provides a preparation process of the traditional Chinese medicine composition of the eczema ointment, which is characterized in that effective components of all components in the composition are fully extracted by a reflux extraction method to prepare the external ointment, and the treatment effect on eczema can be improved.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition of the eczema ointment is characterized by comprising the following components in parts by weight:

2. The traditional Chinese medicine composition of the eczema cream according to claim 1, further comprising 20-30 parts by weight of aloe gel, 5-10 parts by weight of collagen and 0.1-2 parts by weight of hyaluronic acid.

3. The traditional Chinese medicine composition of the eczema cream according to claim 1, further comprising 10-20 parts by weight of apple vinegar.

4. The traditional Chinese medicine composition of eczema cream according to claim 1, further comprising 30-50 parts of coconut oil, 0.1-2 parts of maritime pine bark extract and 0.1-2 parts of maritime pine bark extract.

5. A process for preparing a Chinese medicinal composition for eczema cream according to any one of claims 1 to 4, which comprises:

mixing and crushing garden burnet root, pepper, lithospermum, honeysuckle, coptis, chrysanthemum, radix sophorae flavescentis and fructus cnidii, and then extracting and purifying with ethanol: extracting with ethanol solution to obtain ethanol extract, recovering ethanol from the ethanol extract to obtain purified solution, and concentrating the purified solution to obtain ethanol extract;

6. The process according to claim 5, wherein the volume concentration of the ethanol solution is 50-90%.

7. The process according to claim 5, wherein the ethanol extract from which ethanol has been recovered is concentrated until the relative density of the ethanol extract is 0.85 to 1.01.

8. The manufacturing process according to claim 5, wherein the temperature of the heating reflux extraction is 50 to 70 ℃, the time of the heating reflux extraction is 2 to 5 hours, and the number of times of the heating reflux extraction is 2 to 3.

9. The process according to claim 5, wherein the thickener comprises, by weight, 0.01 to 2.0 parts of gum arabic, 0.01 to 4.0 parts of pectin, 0.01 to 2.0 parts of agar, and 0.01 to 2.0 parts of agar.

10. The process according to claim 5, wherein 0.5 to 2 parts by weight of a natural preservative is added to the mixture during stirring, and the natural preservative is sandalwood leaf flavone.