CN101836945A - Chinese medicinal hair dye and preparation method thereof - Google Patents
Chinese medicinal hair dye and preparation method thereof Download PDFInfo
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- CN101836945A CN101836945A CN201010149217A CN201010149217A CN101836945A CN 101836945 A CN101836945 A CN 101836945A CN 201010149217 A CN201010149217 A CN 201010149217A CN 201010149217 A CN201010149217 A CN 201010149217A CN 101836945 A CN101836945 A CN 101836945A
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Abstract
The invention relates to a Chinese medicinal hair dye, which is prepared from a Chinese medicinal extract containing aucubin, a Chinese medicinal extract containing beta-glucuronide and a substrate. Selected Chinese medicaments have no toxic or side effect and comprise a eucommia bark extract, a bitter apricot seed extract, a peach seed extract and a plum seed extract. The Chinese medicinal hair dye has excellent hair dyeing effect, can dye hairs with common colors including black, has high resistance to daylight and washing and no toxic or side effect or skin irritation, and can fundamentally improve hair quality after being applied for a long time.
Description
Technical field
The invention belongs to the cosmetology technical field, particularly a kind of hair dye.
Background technology
Along with the raising of living standards of the people, hair dye has progressively been come into the common people as a kind of daily cosmetics that change color development, becomes the declaration of modern self-expression and pursuing individuality.On the one hand, hair dye can make the color development back to nature, remedies some congenital defects or posteriori sorry; On the other hand, as individual character and fashionable interspersing, many people require to change own single hair color, to pursue colorful color development.In recent years, hair dyeing had become the wind vane of fashion.
Yet, in the synthetic hair dye of traditional chemical, cause that irritated and carcinogenic is its two big serious problems that face.From the hair dye data of accumulation, people have been well understood to the oxidative coloration of hair agent that contains phenylenediamine skin have been produced sensitization.Through the U.S. FDA statistics, use hair dye skin allergy rate up to 0.15%.May be carcinogenic about hair dye, relevant report is a lot, has caused people's very big concern, has also increased the worry of people to existing hair dye safety simultaneously.Along with progressively improving and the continuous progress of the science of improving looks of health of people consciousness, people press for safety non-toxic, can not cause the botanical hair dye of serious toxic and side effects.
Summary of the invention
But purpose of the present invention is exactly Chinese medicine hair dye that provides at the situation of above-mentioned background technology a kind of safe and harmless non-stimulated and life-time service and preparation method thereof.
Chinese medicine hair dye of the present invention is made of Chinese medicine extract A, Chinese medicine extract B and substrate, wherein: contain aucubin among the Chinese medicine extract A; Contain beta-glucosidase among the Chinese medicine extract B; The weight ratio of aucubin and beta-glucosidase is 1: 0.2~1: 2 in the hair dye.
Chinese medicine extract A can be Cortex Eucommiae extract.Chinese medicine extract B can be single thing or its mixture of Semen Armeniacae Amarum extract, Semen Persicae extract, Fructus Pruni salicinae core extract.
The preparation method of Chinese medicine hair dye of the present invention is made of following step:
1, from the Chinese medicine that contains aucubin, carry out Chinese medicine extraction to obtain Chinese medicine extract A;
2, from the Chinese medicine that contains beta-glucosidase, carry out Chinese medicine extraction to obtain Chinese medicine extract B;
3, Chinese medicine extract A and corresponding substrate and an amount of excipient are mixed mutually and make corresponding dosage forms to obtain the liquid preparation of Chinese medicine extract A;
4, Chinese medicine extract B and corresponding substrate and an amount of excipient are mixed mutually and make corresponding dosage forms to obtain the liquid preparation of Chinese medicine extract B;
5, calculated the dosage of the liquid preparation of the liquid preparation of Chinese medicine extract A and Chinese medicine extract B in 1: 0.2~1: 2.0 according to the content weight ratio of mixing back aucubin and beta-glucosidase, and it is mixed by this dosage, obtain the Chinese medicine hair dye.
Chinese medicine extract A can the Cortex Eucommiae be a raw material, through solvent extraction, solvent extraction, purification by macroporous resin, in conjunction with being prepared into the extract that main component is an aucubin after concentrating under reduced pressure, the lyophilization.
Chinese medicine extract B can fresh or exsiccant Semen Armeniacae Amarum, Semen Persicae, Fructus Pruni salicinae core are raw material, through being prepared into the extract that main component is a beta-glucosidase after solvent extraction, centrifugal, the lyophilization.
Chinese medicine extract A is with the Cortex Eucommiae (comprise Cortex Eucommiae seed, Cortex Eucommiae, Folium Eucommiae is single or its combination) when being raw material, raw material is after appropriateness is pulverized, adopting aquiferous ethanol or dehydrated alcohol is extractant, concentration of alcohol is from 10-100%, the liquid material was advisable than 1: 2~1: 15, reflux, extract, 2-3 time, each 30-150 minute.Said extracted liquid gets extractum through concentrating under reduced pressure, extractum with an amount of distilled water suspendible after, adopt solvent extraction to remove partial impurities, adopt the purification by macroporous resin method to obtain to contain the higher Chinese medicine extract A of aucubin again.
When Chinese medicine extract B is raw material with fresh or exsiccant Semen Armeniacae Amarum, Semen Persicae, Fructus Pruni salicinae core etc., after raw material is pulverized weakly polar organic solvent defats such as back employing ether, cyclohexane extraction, petroleum ether through appropriateness, with the ammonia lixiviate of low concentration, lixiviating solution transfers the specific activity of enzyme that adopts after the pH 95% ethanol precipitation to obtain to contain the higher Chinese medicine extract B of beta-glucosidase and its contained beta-glucosidase bigger.
Chinese medicine extract A and Chinese medicine extract B are added excipient and medicine and cosmetics substrate commonly used respectively, make corresponding dosage forms, as liquid preparations such as unguentum, Emulsion, water preparation, mousses, with both according to the suitable proportion mix homogeneously after, can obtain the Chinese medicine hair dye of different colours.It is clean during use it to be applied on the hair 30-60 minute afterflush of reaction, hair can be caught corresponding color.Hair after the dyeing can variable color or fade after shampoo repeatedly washs, simultaneously dye color daylight had stronger resistance, under sun exposure, also can not fade or variable color.
Raw material of the present invention all comes from nontoxic Chinese medicine, and is without any side effects, safe and reliable.It is called in the substrate proves that through the rabbit skin irritation test this hair dye does not have any stimulation to skin.
In the selected Chinese medicine of the present invention: the Cortex Eucommiae has the effect of invigorating the liver and kidney, bone and muscle strengthening, and the traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, and main bone is given birth to marrow and had one's ideas straightened out in sending out, and the Cortex Eucommiae that therefore has the invigorating the liver and kidney effect can strengthen the nutrition of hair from improving hair quality in essence; Chinese medicines such as Semen Armeniacae Amarum, Semen Persicae or Fructus Pruni salicinae core, not only edible, also be simultaneously cosmetics such as beauty treatment, skin Caring raw materials commonly used.Therefore the present invention has beauty treatment, face-nursing function simultaneously.
The specific embodiment
Three following embodiment are further introductions that the present invention is done:
Embodiment one:
With Cortex Eucommiae seed and Semen Armeniacae Amarum decoction pieces for selecting Chinese medicine for use.
1, preparation Chinese medicine extract A:
Get dry Cortex Eucommiae seed 1.0Kg and be ground into coarse powder through Universalpulverizer, place the round-bottomed flask of 10L, add 6 liter of 95% alcohol reflux 2 times, each 1.5 hours, with 4 layers of filtered through gauze, merge 2 extracting solution and reclaim ethanol to doing, obtain brown extractum 123g (12.3% yield) at 50 ℃ of following concentrating under reduced pressure.
Extractum adds 500ml distilled water suspendible, adds isopyknic petroleum ether extraction 3-4 time, clarifies until water layer.Under 50 ℃, be evaporated to 300ml through the water layer behind the petroleum ether extraction.With HPLC the aucubin in the water layer extractum behind petroleum ether extraction is carried out assay, the content of aucubin in water layer extractum is 40.5%.
Take by weighing the water layer extractum 102g behind petroleum ether extraction, it is carried out purification by XDA-7 resin (amount of resin is weight in wet base 1kg), behind sample on the flow velocity of 10ml/min, standing adsorption half an hour.With about 1500ml water elution, change clarification by muddiness subsequently, stop water elution until eluent.Use about 5000ml10% ethanol elution instead.Reclaim under reduced pressure 10% ethanol elution part obtains Chinese medicine extract A (Cortex Eucommiae seed extract).
With HPLC the aucubin in this extract is carried out assay, the content of aucubin is 79.4%.
2, preparation Chinese medicine extract B:
Get exsiccant Semen Armeniacae Amarum decoction pieces 100g, pulverize the back and cross 10 mesh sieves, medicinal residues were sloughed oils and fats, filtered through gauze in 24 hours with 400ml ether merceration, filtering residue added 400ml 0.06mol/L ammonia merceration 24 hours, filtered through gauze is collected filtrate, medicinal residues reuse 300ml 0.06mol/L ammonia merceration 24 hours, discard medicinal residues, merging filtrate adds the glacial acetic acid pH=4.0 that neutralizes, and the limit edged stirs, there are a large amount of precipitations to separate out, leave standstill a moment, supernatant sucking filtration, lower floor's suspension centrifugal 5 minutes at 4000r/min, collect filtrate, 95% ethanol that adds 4 times of amounts, protein precipitation ,-10 ℃ left standstill 6 hours, sucking filtration, collecting precipitation with the washing with alcohol precipitation for several times, obtains Chinese medicine extract B (Semen Armeniacae Amarum extract) after-50 ℃ of lyophilizations.
3,5 one dinitrosalicylic acid (DNS) methods of employing are measured the ratio vigor of beta-glucosidase in this extract, and recording specific activity of enzyme under the ultraviolet spectrophotometer is 21.9.
3, the liquid preparation of preparation Chinese medicine extract A:
1) get:
Cera alba 5.0g glyceryl monostearate 3.5g
Lanoline 1.0g polyoxyethylene sorbitan monostearate 3.0g
Paraffin 2.0g liquid paraffin 20g
Oleum lini 10.0g;
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract A20 gram, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract A behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of aucubin is 16%.
4, the liquid preparation of preparation Chinese medicine extract B:
1) get:
CMC-Na 10.0g gelatin 30g Tween-80 10g
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract B 4 grams, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract B behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of beta-glucosidase is 4%.
5, preparation Chinese medicine hair dye:
1) dosage that calculates the liquid preparation of the liquid preparation of Chinese medicine extract A and Chinese medicine extract B at 1: 0.2 according to the content weight ratio of mixing back aucubin and beta-glucosidase is respectively 40 grams and 32 and restrains;
2) take out the liquid preparation of Chinese medicine extract A and B respectively according to aforementioned calculation gained dosage, it is carried out uniform mixing promptly obtain brownish black Chinese medicine hair dye.
According to externally used paste skin irritation test operational approach, the present embodiment unguentum rabbit of being in of having hair dyed is experimentized, what experimental results show that above-mentioned substrate is made into is tried thing to the skin nonirritant.
Embodiment two:
With Cortex Eucommiae and Fructus Pruni salicinae core for selecting Chinese medicine for use:
1, preparation Chinese medicine extract A:
Get dry Cortex Eucommiae 1.0Kg and become coarse powder, place the round-bottomed flask of 10L, add 7.5 liter of 95% alcohol reflux 2 times, each 1 hour,, merge 2 times extracting solution with 4 layers of filtered through gauze through Universalpulverizer.Extracting solution reclaims ethanol to doing at 50 ℃ of following concentrating under reduced pressure, obtains brown extractum 146g (14.6% yield).
Extractum adds 1000ml distilled water suspendible, add isopyknic petroleum ether extraction 4 times, after being evaporated to 500ml under 50 ℃, it is carried out purification by S-8 resin (amount of resin is weight in wet base 1kg) through the water layer behind the petroleum ether extraction, behind sample on the flow velocity of 10ml/min, standing adsorption half an hour.With about 1000ml water elution, change clarification by muddiness subsequently, stop water elution until eluent.Use about 4000ml10% ethanol elution instead.Reclaim under reduced pressure 10% ethanol elution part obtains Chinese medicine extract A (Cortex Eucommiae extract).
With HPLC the aucubin in this extract is carried out assay, the content of aucubin is 77.2%.
2, preparation Chinese medicine extract B:
Get exsiccant Fructus Pruni salicinae core decoction pieces 100g, pulverize the back and cross 10 mesh sieves, medicinal residues were sloughed oils and fats, filtered through gauze in 24 hours with 400ml ether merceration, filtering residue added 400ml 0.06mol/L ammonia merceration 24 hours, filtered through gauze is collected filtrate, medicinal residues reuse 300ml 0.06mol/L ammonia merceration 24 hours, discard medicinal residues, merging filtrate adds the glacial acetic acid pH=4.0 that neutralizes, and the limit edged stirs, there are a large amount of precipitations to separate out, leave standstill a moment, supernatant sucking filtration, lower floor's suspension centrifugal 5 minutes at 4000r/min, collect filtrate, 95% ethanol that adds 4 times of amounts, protein precipitation ,-10 ℃ left standstill 6 hours, sucking filtration, collecting precipitation with the washing with alcohol precipitation for several times, obtains Chinese medicine extract B (Fructus Pruni salicinae core extract) after-50 ℃ of lyophilizations.
3,5 one dinitrosalicylic acid (DNS) methods of employing are measured the ratio vigor of beta-glucosidase in this extract, and recording specific activity of enzyme under the ultraviolet spectrophotometer is 20.1.
3, the liquid preparation of preparation Chinese medicine extract A:
1) get:
Cera alba 5.0g glyceryl monostearate 3.5g
Lanoline 1.0g polyoxyethylene sorbitan monostearate 3.0g
Paraffin 2.0g liquid paraffin 20g
Oleum lini 10.0g;
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract A20 gram again, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract A behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of aucubin is 15.4%.
4, the liquid preparation of preparation Chinese medicine extract B:
1) get:
CMC-Na 10.0g gelatin 25g Tween-80 10g;
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract B 15.4 grams, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract B behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of beta-glucosidase is 15.4%.
5, preparation Chinese medicine hair dye:
1) dosage that calculates the liquid preparation of the liquid preparation of Chinese medicine extract A and Chinese medicine extract B at 1: 1 according to the content weight ratio of mixing back aucubin and beta-glucosidase is respectively 50 grams and 50 and restrains;
2) take out the liquid preparation of Chinese medicine extract A and B respectively according to aforementioned calculation gained dosage, it is carried out uniform mixing promptly obtain corvinus Chinese medicine hair dye.
According to externally used paste skin irritation test operational approach, the present embodiment unguentum rabbit of being in of having hair dyed is experimentized, what experimental results show that above-mentioned substrate is made into is tried thing to the skin nonirritant.
Embodiment three:
With Folium Eucommiae and Semen Persicae for selecting Chinese medicine for use.
1, preparation Chinese medicine extract A:
Dry Folium Eucommiae 0.5Kg rubs into coarse powder, places the round-bottomed flask of 10L, adds 5 liter of 95% alcohol reflux 2 times, each 1 hour, with 4 layers of filtered through gauze, merges 2 times extracting solution.Extracting solution reclaims ethanol to doing at 50 ℃ of following concentrating under reduced pressure, obtains brown extractum 91g (18.2% yield).
Extractum adds 800ml distilled water suspendible, adds isopyknic petroleum ether extraction 4 times, and is colourless until petroleum ether layer.After being evaporated to 400ml under 50 ℃, it is carried out purification through the water layer behind the petroleum ether extraction by XDA-7 resin (amount of resin is weight in wet base 0.8kg), behind sample on the flow velocity of 10ml/min, standing adsorption half an hour.With behind about 1200ml water elution, use about 4500ml 10% ethanol elution again instead subsequently.Reclaim under reduced pressure 10% ethanol elution part obtains Chinese medicine extract A (Folium Eucommiae extract).
With HPLC the aucubin in this extract is carried out assay, the content of aucubin is 72.1%.
2, preparation Chinese medicine extract B:
Get exsiccant Semen Persicae decoction pieces 100g, pulverize the back and cross 10 sieves, medicinal residues were sloughed oils and fats, filtered through gauze in 24 hours with 400ml ether merceration, filtering residue added 400ml 0.06mol/L ammonia merceration 24 hours, filtered through gauze is collected filtrate, medicinal residues reuse 300ml 0.06mol/L ammonia merceration 24 hours, discard medicinal residues, merging filtrate adds the glacial acetic acid pH=4.0 that neutralizes, and the limit edged stirs, there are a large amount of precipitations to separate out, leave standstill a moment, supernatant sucking filtration, lower floor's suspension centrifugal 5 minutes at 4000r/min, collect filtrate, 95% ethanol that adds 4 times of amounts, protein precipitation ,-10 ℃ left standstill 6 hours, sucking filtration, collecting precipitation with the washing with alcohol precipitation for several times, obtains Chinese medicine extract B (Semen Persicae extract) after-50 ℃ of lyophilizations.
3,5 one dinitrosalicylic acid (DNS) methods of employing are measured the ratio vigor of beta-glucosidase in this extract, and recording specific activity of enzyme under the ultraviolet spectrophotometer is 21.2.
3, the liquid preparation of preparation Chinese medicine extract A:
1) get:
Cera alba 5.0g glyceryl monostearate 3.5g
Lanoline 1.0g polyoxyethylene sorbitan monostearate 3.0g
Paraffin 2.0g liquid paraffin 25g
Oleum lini 10.0g;
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract A 10 grams again, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract A behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of aucubin is 7.2%.
4, the liquid preparation of preparation Chinese medicine extract B:
1) get:
CMC-Na 10.0g gelatin 25g Tween-80 10g;
2) under the condition of slight fever, mix and constantly stir, make its mix homogeneously, add Chinese medicine extract B 14.4 grams, add distilled water to 100 gram again, promptly obtain the liquid preparation of Chinese medicine extract B behind the mix homogeneously.
3) after testing, in the aforesaid liquid preparation, the content of beta-glucosidase is 14.4%.
5, preparation Chinese medicine hair dye:
1) dosage that calculates the liquid preparation of the liquid preparation of Chinese medicine extract A and Chinese medicine extract B at 1: 2 according to the content weight ratio of mixing back aucubin and beta-glucosidase is respectively 50 grams and 50 and restrains;
2) take out the liquid preparation of Chinese medicine extract A and B respectively according to aforementioned calculation gained dosage, it is carried out uniform mixing promptly obtain pale brown color Chinese medicine hair dye.
According to externally used paste skin irritation test operational approach, the present embodiment unguentum rabbit of being in of having hair dyed is experimentized, what experimental results show that above-mentioned substrate is made into is tried thing to the skin nonirritant.
Claims (8)
1. a Chinese medicine hair dye is made of Chinese medicine extract A, Chinese medicine extract B and substrate, it is characterized in that:
1) contains aucubin among the described Chinese medicine extract A;
2) contain beta-glucosidase among the described Chinese medicine extract B;
3) weight ratio of aucubin and beta-glucosidase is 1: 0.2~1: 2 in the described hair dye.
2. a kind of Chinese medicine hair dye according to claim 1 is characterized in that: described Chinese medicine extract A is a Cortex Eucommiae extract.
3. a kind of Chinese medicine hair dye according to claim 1 and 2 is characterized in that: described Chinese medicine extract B is single thing or its mixture of Semen Armeniacae Amarum extract, Semen Persicae extract, Fructus Pruni salicinae core extract.
4. method for preparing the described a kind of Chinese medicine hair dye of claim 1 is characterized in that being made of following step:
1) from the Chinese medicine that contains aucubin, carries out Chinese medicine extraction to obtain Chinese medicine extract A;
2) from the Chinese medicine that contains beta-glucosidase, carry out Chinese medicine extraction to obtain Chinese medicine extract B;
3) Chinese medicine extract A and corresponding substrate and an amount of excipient are mixed mutually and make corresponding dosage forms to obtain the liquid preparation of Chinese medicine extract A;
4) Chinese medicine extract B and corresponding substrate and an amount of excipient are mixed mutually and make corresponding dosage forms to obtain the liquid preparation of Chinese medicine extract B;
5) be to calculate the dosage of the liquid preparation of the liquid preparation of Chinese medicine extract A and Chinese medicine extract B in 1: 0.2~1: 2.0 according to the content weight ratio of mixing back aucubin and beta-glucosidase, and it mixed, obtain the Chinese medicine hair dye by this dosage.
5. a kind of method for preparing the Chinese medicine hair dye according to claim 4, it is characterized in that: Chinese medicine extract A is to be raw material with the Cortex Eucommiae, through solvent extraction, solvent extraction, purification by macroporous resin, be the extract of aucubin in conjunction with the main component that is prepared into after concentrating under reduced pressure, the lyophilization.
6. according to claim 4 or 5 described a kind of methods that prepare the Chinese medicine hair dye, it is characterized in that: Chinese medicine extract B is to be raw material with fresh or exsiccant Semen Armeniacae Amarum, and the main component that is prepared into after solvent extraction, centrifugal, lyophilization is the extract of beta-glucosidase.
7. according to claim 4 or 5 described a kind of methods that prepare the Chinese medicine hair dye, it is characterized in that: Chinese medicine extract B is to be raw material with fresh or exsiccant Semen Persicae, and the main component that is prepared into after solvent extraction, centrifugal, lyophilization is the extract of beta-glucosidase.
8. according to claim 4 or 5 described a kind of methods that prepare the Chinese medicine hair dye, it is characterized in that: Chinese medicine extract B is to be raw material with fresh or exsiccant Fructus Pruni salicinae core, and the main component that is prepared into after solvent extraction, centrifugal, lyophilization is the extract of beta-glucosidase.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103565686A (en) * | 2012-08-06 | 2014-02-12 | 武汉科亿华科技有限公司 | Permanent plant hair dye and preparation method thereof |
CN103815141A (en) * | 2014-01-22 | 2014-05-28 | 向华 | Eucommia ulmoides leaf feed additive and preparation method thereof |
CN104391020A (en) * | 2014-11-04 | 2015-03-04 | 济南大学 | Electrochemical aptamer sensor, preparation method and application thereof |
CN105456053A (en) * | 2015-04-17 | 2016-04-06 | 武汉海吉亚生物科技有限公司 | Permanent hair dye prepared from dye and enzyme sourced from natural plants |
CN105963419A (en) * | 2016-05-11 | 2016-09-28 | 天津大学 | Medicine composition with attenuated peach kernels |
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JPH03220115A (en) * | 1990-01-23 | 1991-09-27 | Rokuro Kiyohara | Hair dyeing cosmetic |
CN1054716A (en) * | 1990-02-02 | 1991-09-25 | 株式会社常绿汉方制药 | With iridoid glycoside and the hair dyeing of glycoside unit thereof |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103565686A (en) * | 2012-08-06 | 2014-02-12 | 武汉科亿华科技有限公司 | Permanent plant hair dye and preparation method thereof |
CN103815141A (en) * | 2014-01-22 | 2014-05-28 | 向华 | Eucommia ulmoides leaf feed additive and preparation method thereof |
CN104391020A (en) * | 2014-11-04 | 2015-03-04 | 济南大学 | Electrochemical aptamer sensor, preparation method and application thereof |
CN105456053A (en) * | 2015-04-17 | 2016-04-06 | 武汉海吉亚生物科技有限公司 | Permanent hair dye prepared from dye and enzyme sourced from natural plants |
CN105456053B (en) * | 2015-04-17 | 2018-07-27 | 武汉海吉亚生物科技有限公司 | Permanent hairdye prepared by a kind of dyestuff and enzyme by natural botanical source |
CN105963419A (en) * | 2016-05-11 | 2016-09-28 | 天津大学 | Medicine composition with attenuated peach kernels |
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