CN106473995A - The extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film - Google Patents
The extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses the extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film, it is to destroy cell wall with cellulase, Flavonoid substances are made to discharge, then isolating protein is gone using tannic acid, alkalescence small-micelle water extracts to the effective ingredient of Herba Bidentis Bipinnatae slag remaining again, the Herba Bidentis Bipinnatae extract of the modern biotechnologies such as micro-filtration membrane purification liquid preparation, rich in the antioxidant contents such as polyphenol, flavone and anti-inflammation composition, extract and separate yield high, can be used for preparing facial film.
Description
Technical field
The present invention relates to a kind of method of effective component extracting from plant, particularly to a kind of Herba Bidentis Bipinnatae effective ingredient
Extracting method and its purposes preparing facial film.
Background technology
Herba Bidentis Bipinnatae,【Classification system】Bidens pilosa L.；【Another name】Terrible hairpin grass, shrimp claw plant, the crab claw grass, to fork grass,
Viscous people's grass, adhesion, bean dregs grass, annual herb, stem is upright, blunt four prismatics.The lower portion of the stem leaf is less, rarely foliolate plumage
Shape compound leaf, both sides lobule ellipse or ovate-elliptic.Flower head diameter 8-9 millimeter.Involucre base portion is by pubescence, strip spoon
Shape, top is slightly wider.No ligulate flower, disc floret tubular, limb 5 fissure.Achene black, bar shaped, slightly flat, have rib, top has sparse tumor
Shape projection and bristle, 3-4 piece of top prickle, have glochid.Herba Bidentis Bipinnatae, produces Chinese many provinces and regions, is born in by village, roadside and wasteland
In, it is that folks of china commonly uses medical herbs, have functions that heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, urgency
Property appendicitis, acute icterohepatitises, gastroenteritiss, Fengshi Guanjie pain, malaria, external control furuncle, venom, traumatic injury swell
Bitterly.Herba Bidentis Bipinnatae main component is flavonoid glycoside, saponin, tannin, polyphenol, coumarin, iodine, choline, aminoacid, vitamin etc., wherein
Flavone compound is one of natural anti-oxidation activated product of receiving much attention at present.In each position of Herba Bidentis Bipinnatae, flavones ingredient has
Larger difference, in flowering fruit bearing stage, general flavone content higher (respectively 6.67% and 6.68%) in leaf and inflorescence, in stem branch, content is relatively
Low (0.89%).Herba Bidentis Bipinnatae contains abundant aminoacid, such as aspartic acid, threonine, serine, glutamic acid, alanine, different bright
17 kinds of aminoacid such as propylhomoserin, tyrosine, wherein 8 kinds is essential amino acid, gross protein 157.89g/kg.
As follows with regard to the document from Herba Bidentis Bipinnatae effective component extracting：
1st, Chinese patent, application number：201610397854 .7；Applicant：Often have an area of；Denomination of invention：The system of Sticktight general flavone
Medicine is applied；Summary：The present invention provides application in preparation treatment atherosclerosiss medicine for the Sticktight general flavone.Additionally, this
Invention additionally provides a kind of pharmaceutical composition, comprise the Sticktight general flavone of effective dose and one or more pharmaceutically acceptable
Adjuvant.It is verified by experiments, Sticktight general flavone energy substantially reduction blood fat, raising serum NO levels, reduction ET-1 content, and suppress
Plaque progression, therefore can be with effectively treatment atherosclerosiss.
2nd, Chinese patent, application number：200710176330.6；Denomination of invention：The preparation method of Sticktight general flavone；Pluck
Will：The invention discloses a kind of preparation method of Sticktight general flavone, after Herba Bidentis Bipinnatae is with alcohol reflux, reclaim ethanol at least
Amount, can get Sticktight general flavone, gained after standing remove impurity, organic solvent degreasing, mixed extractant solvent enrichment, resin purification
Extractive of general flavone flavones content is high, and more than or equal to 50%, process is simple is feasible, and total extract yield yield is high, suitable industrialization
Produce.The extractive of general flavone of gained of the present invention has lowering blood pressure and blood fat, blood sugar lowering, antioxidation, prevents the work of hepatic fibrosis
With can be used for preparing having and treating cardiovascular disease effect, lowering blood pressure and blood fat, blood sugar lowering and the medicine preventing hepatic fibrosis.
3rd, Chinese patent, application number：200710024786.0；Denomination of invention：Sticktight general flavone is inhaled in preparation preventing and treating blood
Application in worm property hepatic fibrosis medicines；Summary：The present invention relates to the purposes of Sticktight general flavone, relate in particular to Herba Bidentis Bipinnatae
Purposes in preparation preventing and treating hepatic fibrosis due to schistosoma japonicum infection medicine for the total flavones.Medicine heat-clearing and toxic substances removing of the present invention, promoting blood circulation to remove blood stasis, soothing liver-QI
Spleen invigorating, particularly has the immunocompetence improved liver function, improve body, adjusts the effect of immunologic derangement.The present invention is applied to
The hepatic fibrosis that schistosomicide sexually transmitted disease (STD) causes, and act on multiple links, determined curative effect.For treating or preventing schistosomicide to cause
Hepatic fibrosis adopt oral administration, taking convenience, toxic and side effects are little, Long-term taking medicine non-hazardous.
4th, Chinese patent, application number：200510097342.0；Denomination of invention：Sticktight general flavone is preparing anti-treating the liver fibre
Application in dimensionization chemical medicine thing；Summary：The present invention relates to the purposes of Sticktight general flavone, it is that Sticktight general flavone in prevention and is controlled
Treat the application in hepatic fibrosis chemical medicine thing.Sticktight general flavone is the effective site extracted from Herba Bidentis Bipinnatae.The present invention passes through dynamic
Thing description of test its to the acute liver damage that mouse carbon tetrachloride causes, there is protective effect；Carbon tetrachloride, porcine blood serum cause
Rat Liver Fibrosis Model proves that Sticktight general flavone has preferable preventive and therapeutic action to hepatic fibrosis.Result is demonstrate,proved
Bright Sticktight general flavone has definite anti-fibrosis effect, therefore can be used to prepare the medicine of prevention and treatment hepatic fibrosis.
5th, Chinese patent, application number：200510097338.4；Applicant：An Wei medical university；Denomination of invention：Herba Bidentis Bipinnatae
Total flavones prevent and treat the application in viral hepatitis medicine in preparation；Summary：The invention belongs to the field of Chinese medicines, it is related to a kind of antiviral property
The medicine of hepatitis is and in particular to Sticktight general flavone prevents and treats the purposes in viral hepatitis medicine in preparation.Medicine of the present invention is clear
Thermal detoxification, promoting blood circulation to remove blood stasis, the liver soothing and the spleen invigorating, particularly have the immunocompetence improved liver function, improve body, adjust immunologic derangement
Effect, thus enhancing body resist hepatitis viruss ability, suppression hepatitis viruss duplication.The present invention is applied to various virus
Property hepatitis, and act on multiple links, determined curative effect.Adopt oral administration, the side of taking for treatment or preventing viral hepatitis
Just, toxic and side effects are little, Long-term taking medicine non-hazardous.
In document disclosed above, most of report is application in medicine for the Sticktight general flavone, wherein also relates to total
The extracting method of flavone, patent 2 is that Herba Bidentis Bipinnatae first first carries out alcohol extraction, clear liquid with n-hexane extraction defat, continue with n-butyl alcohol-
Ethyl acetate mixed extractant solvent, enrichment flavone, concentrating under reduced pressure, after solvent, concentrated solution dilute, upper macroporous absorption tree
Fat, uses ethanol solution eluting, collects eluent, and concentrate drying obtains total flavones dry cream leaching powder；Patent 3 and the extraction of 4 total flavones
Method is identical with patent 5；And patent 5 uses and Herba Bidentis Bipinnatae first carries out alcohol extraction, recycle resin purification, reclaim ethanol, do
Dry obtain extract.Above-mentioned 4 kinds of different extracting method obtain the Herba Bidentis Bipinnatae effective ingredient of different purposes, but some methods carry
Take not exclusively so that root of Broussonetiapapyrifera(I)vent resource fails to make full use of.
Content of the invention
It is an object of the invention to provide a kind of method from Herba Bidentis Bipinnatae effective component extracting, it is to destroy carefully with cellulase
Cell wall, makes Flavonoid substances discharge, and then removes isolating protein using tannic acid, alkalescence small-micelle water is again to Bidens bipinnata
The effective ingredient of careless slag remaining is extracted, and the Herba Bidentis Bipinnatae of the modern biotechnology such as micro-filtration membrane purification liquid preparation is extracted
Thing, rich in the antioxidant contents such as polyphenol, flavone and anti-inflammation composition, extracts and separates yield height, can be used for preparing facial film.
The technical scheme is that and be achieved in that：
The extracting method of Herba Bidentis Bipinnatae effective ingredient, comprises the steps：
1）Remove soil and the weeds on spanishneedles herb leaf first, spanishneedles herb leaf tap water wash clean dries in the shade, then using super
Spanishneedles herb leaf is carried out pulverization process by thin mechanical crusher, reaches 1000-2000 mesh, obtains spanishneedles herb leaf powder；
2）According to the weight of spanishneedles herb leaf powder, add the water soaking step 1 of 5-10 times amount）The spanishneedles herb leaf powder obtaining, with
When in reacting by heating kettle add spanishneedles herb leaf powder weight 1 ‰ -5 ‰ cellulase, adjustment pH be 6-7, temperature be 40-50
DEG C, mixing speed is 20-35rpm, digests 2-4hr；The compounding of spanishneedles herb leaf weight 1 ‰ -5 ‰ is added after cellulase degradation
Protease, adjustment pH is 6-7, and temperature is 40-50 DEG C, and mixing speed is 20-35rpm, digests 2-4hr；Compounding protease hydrolyzed
Afterwards, processing 2～5min under 90-100 DEG C of high temperature makes compounding protease inactivation；Centrifugation, obtains enzymolysis solution and Herba Bidentis Bipinnatae slag；
3）Using alkalescence small-micelle water to step 2）In Herba Bidentis Bipinnatae slag, per kilogram Herba Bidentis Bipinnatae slag add 5-8 rise alkalescence
Small-micelle water；Extract 1-2 hour at a temperature of 15-25 DEG C, be again separate out extracting solution and Herba Bidentis Bipinnatae slag；
4）Combining step 2）With step 3）Herba Bidentis Bipinnatae slag, obtain mix Herba Bidentis Bipinnatae slag, and mix Herba Bidentis Bipinnatae slag be used as pig feed；
Combining step 2）Enzymolysis solution and step 3）Extracting solution, obtain mixed extract, mixed extract crossed inorganic ceramic microfiltration
Film, inorganic ceramic micro-filtration membrane aperture is 0.1-1 μm, in microfiltration operation, controls the temperature of mixed extract to be 40-60 DEG C, pressure
For 0.2-0.4 MPa, obtain micro-filtrate；The ethanol solution being 60% with volumetric concentration again carries out eluting to micro-filtrate, obtains eluting
Liquid；Eluent is carried out concentrating under reduced pressure process, reclaims ethanol, drying under reduced pressure becomes dry cream to pulverize 60 mesh sieves, obtains Herba Bidentis Bipinnatae
Extract.
Described alkalescence small-micelle water is using Application No. 201010253226.4, a kind of invention entitled " sky
Method described in the patent of the right eternal making apparatus of alkalescence small-micelle water and its method " prepares, its system
Comprise the following steps as process：Step 1：Water is passed through in making apparatus by water inlet pipe, water sequentially flows through filter and small molecule
Group's water generator, is flowed out by outlet pipe；Step 2：Water flow adjusting valve door on adjustment outlet pipe, by the current in outlet pipe
Amount is adjusted to 20-80mL/min, and the current adjustment that acid-base value adjusts in pipe hollow cavity breaks formula and falls in beading；Step 3：
Container adjusts the outlet water receiving of pipe lower end in acid-base value, you can obtain alkalescence small-micelle water.In the present invention, using weak
Alkaline small group's water extracts to the effective ingredient of Herba Bidentis Bipinnatae slag remaining, improves the yield of effective ingredient, has and extracted
Cheng Wenhe, safety, the feature of environmental protection, it also avoid the harm that conventional strong acid and strong base extraction brings simultaneously.
Described compounding protease is papain and alkaline protease according to 1:1 weight ratio mixes.
The above-mentioned Herba Bidentis Bipinnatae extract preparing can be used to prepare Herba Bidentis Bipinnatae facial film, and Herba Bidentis Bipinnatae facial film is by following weight
The raw material composition of number：Herba Bidentis Bipinnatae extract 5-8；Tender bamboo leaf water 3-5；Fructus Citri Limoniae juice 2-4；Mel 0.5-1；Clabber 3-5；Dimension life
Plain E0.5-1；Jasmin quintessence oil 0.5-1；Fructus Luffae concentrated solution 2-3；Margarita powder 3-5；Flour 10-12.
The manufacture method of Herba Bidentis Bipinnatae facial film is：According to parts by weight, first by Herba Bidentis Bipinnatae extract, Vitamin E, jasmin quintessence oil
It is added in container with Mel, is tuned into pasty state with appropriate distilled water, add clabber, after mix homogeneously, sequentially add Fructus Luffae dense
Contracting liquid, Fructus Citri Limoniae juice, tender bamboo leaf, Margarita powder dough-making powder, stir, obtain facial film serosity, use in 1-3 hour.
Using method is：First clean face, then the facial film serosity preparing is applied on the face, apply once again, and keep within every ten minutes
Moistening, can rinse well after three, 40 minutes；Effect：Speckle dispelling, moisten, delicate, that is, do and take effect；Mechanism：Herba Bidentis Bipinnatae is extracted
The effective ingredient activity of thing is big, and the abundant nutrition composition containing needed by human body is readily absorbed by.
The preparation method of described tender bamboo leaf water is：The tender bamboo leaf of fresh harvesting is cleaned, puts into 4～8 times of its weight
Steaming and decocting 30～60 minutes in boiling water, cooling is placed, and obtains tender bamboo leaf water.
The extracting method of Fructus Luffae concentrated solution is：By Fructus Luffae after physical squeezing, filtered with grid cloth, take filtrate, add filter
3-5 times of mass concentration of liquid weight be 40% ethanol as Extraction solvent, be heated to reflux 20-30 minute at 40-50 DEG C, obtain
Extracting solution；After extracting solution is separated through micro-filtration membrane, ultrafilter membrane, nanofiltration membrane respectively, concentrate, obtain Fructus Luffae concentrated solution.
The substantive distinguishing features of the present invention and significantly progress are：
1st, in the present invention, first with cellulase and compounding protease make plant cell wall loose, rupture, reduce mass transfer resistance
Power, accelerates the release of effective ingredient Flavonoid substances and Polyphenols, thus improving extraction efficiency, adjust simultaneously suitable temperature and
PH value, can make spanishneedles herb leaf effective ingredient Rapid Leaching under gentle extraction conditions, and extraction efficiency is higher；Then adopt
Alkalescence small-micelle water extracts to the effective ingredient of Herba Bidentis Bipinnatae slag remaining, improves the yield of effective ingredient；Again and then
Using inorganic ceramic micro-filtration membrane, can preferably remove the macromole such as microgranule in Herba Bidentis Bipinnatae extracting solution, starch, pectin and protein
Impurity, improves the purity of effective ingredient further；Finally utilize ethanol solution eluting, eluent concentrating under reduced pressure reclaim ethanol,
It is spray-dried, obtain Herba Bidentis Bipinnatae extract.
2nd, in Herba Bidentis Bipinnatae extract of the present invention, more than 60%, polyphenol compound is 30% for the content of flavone compound
More than, the response rate reaches more than 95%, and traditional alcohol-resin method, general flavone content more than 50%, polyphenol compound content
More than 25%, the response rate reaches more than 90%.Thus, it will be seen that using the extracting method of the present invention, the content of flavonoid from
50% brings up to 60%, and polyphenol compound content also brings up to 30% from 25%, and its response rate also brings up to 95% from 90%.
3rd, the Herba Bidentis Bipinnatae extract being obtained by the extracting method of the present invention, rich in antioxidant contents such as polyphenol, flavone and
Anti-inflammation composition, make facial film can the free radical piled up except skin cell metabolism of high-efficient cleaning, improve human detoxification and
Defensive enginery, makes the vigor of senile cell be recovered, and accelerates to remove dead Skin Cell, promotes the new life of Skin Cell,
Delaying skin aging.So that because the age increases the facial macula lutea leading to and shoals and then disappear, pore shrinks, diminishes or even disappear
Lose, facial thickness wrinkle improves.Life-time service can make skin delicate, smooth, elastic return, is rich in youth gloss.
Specific embodiment
Embodiment 1
The extracting method of Herba Bidentis Bipinnatae effective ingredient, comprises the steps：
1）Remove soil and the weeds on spanishneedles herb leaf first, spanishneedles herb leaf tap water wash clean dries in the shade, then using super
Spanishneedles herb leaf is carried out pulverization process by thin mechanical crusher, reaches 1000-2000 mesh, obtains spanishneedles herb leaf powder；
2）According to the weight of spanishneedles herb leaf powder, add the water soaking step 1 of 5 times amount）The spanishneedles herb leaf powder obtaining, exists simultaneously
The cellulase of spanishneedles herb leaf powder weight 1 ‰ is added, adjustment pH is 6-7, temperature is 40 DEG C, mixing speed in reacting by heating kettle
For 35rpm, digest 4hr；The compounding protease of spanishneedles herb leaf weight 1 ‰ is added, adjustment pH is 6-7 after cellulase degradation,
Temperature is 40 DEG C, and mixing speed is 35rpm, digests 4hr；After compounding protease hydrolyzed, processing 5min under 90 DEG C of high temperature makes again
Join protease inactivation；Centrifugation, obtains enzymolysis solution and Herba Bidentis Bipinnatae slag；
3）Using alkalescence small-micelle water to step 2）In Herba Bidentis Bipinnatae slag, per kilogram Herba Bidentis Bipinnatae slag add 5 liters of alkalescencies little
Micel water；Extract 2 hours at a temperature of 15 DEG C, be again separate out extracting solution and Herba Bidentis Bipinnatae slag；
4）Combining step 2）With step 3）Herba Bidentis Bipinnatae slag, obtain mix Herba Bidentis Bipinnatae slag, and mix Herba Bidentis Bipinnatae slag be used as pig feed；
Combining step 2）Enzymolysis solution and step 3）Extracting solution, obtain mixed extract, mixed extract crossed inorganic ceramic microfiltration
Film, inorganic ceramic micro-filtration membrane aperture is 0.1-1 μm, in microfiltration operation, controls the temperature of mixed extract to be 40 DEG C, pressure is
0.4 MPa, obtains micro-filtrate；The ethanol solution being 60% with volumetric concentration again carries out eluting to micro-filtrate, obtains eluent；Will
Eluent carries out concentrating under reduced pressure process, reclaims ethanol, and drying under reduced pressure becomes dry cream to pulverize 60 mesh sieves, obtains Herba Bidentis Bipinnatae and extracts
Thing.
Described alkalescence small-micelle water is using Application No. 201010253226.4, a kind of invention entitled " sky
Method described in the patent of the right eternal making apparatus of alkalescence small-micelle water and its method " prepares, its system
Comprise the following steps as process：Step 1：Water is passed through in making apparatus by water inlet pipe, water sequentially flows through filter and small molecule
Group's water generator, is flowed out by outlet pipe；Step 2：Water flow adjusting valve door on adjustment outlet pipe, by the current in outlet pipe
Amount is adjusted to 20-80mL/min, and the current adjustment that acid-base value adjusts in pipe hollow cavity breaks formula and falls in beading；Step 3：
Container adjusts the outlet water receiving of pipe lower end in acid-base value, you can obtain alkalescence small-micelle water.
Described compounding protease is papain and alkaline protease according to 1:1 weight ratio mixes.
The above-mentioned Herba Bidentis Bipinnatae extract preparing can be used to prepare Herba Bidentis Bipinnatae facial film, and Herba Bidentis Bipinnatae facial film comprises to weigh as follows
The raw material composition of amount number：Herba Bidentis Bipinnatae extract 5；Tender bamboo leaf water 3；Fructus Citri Limoniae juice 2；Mel 0.5；Clabber 3；Vitamin E 0.5；
Jasmin quintessence oil 0.5；Fructus Luffae concentrated solution 2；Margarita powder 3；Flour 10.
The manufacture method of Herba Bidentis Bipinnatae facial film is：According to parts by weight, first by Herba Bidentis Bipinnatae extract, Vitamin E, jasmin quintessence oil
It is added in container with Mel, is tuned into pasty state with appropriate distilled water, add clabber, after mix homogeneously, sequentially add Fructus Luffae dense
Contracting liquid, Fructus Citri Limoniae juice, tender bamboo leaf, Margarita powder dough-making powder, stir, obtain facial film serosity, use in 1-3 hour.
The preparation method of described tender bamboo leaf water is：The tender bamboo leaf of fresh harvesting is cleaned, puts into 4～8 times of its weight
Steaming and decocting 30～60 minutes in boiling water, cooling is placed, and obtains tender bamboo leaf water.
The extracting method of Fructus Luffae concentrated solution is：By Fructus Luffae after physical squeezing, filtered with grid cloth, take filtrate, add filter
3-5 times of mass concentration of liquid weight be 40% ethanol as Extraction solvent, be heated to reflux 20-30 minute at 40-50 DEG C, obtain
Extracting solution；After extracting solution is separated through micro-filtration membrane, ultrafilter membrane, nanofiltration membrane respectively, concentrate, obtain Fructus Luffae concentrated solution.
Embodiment 2
The extracting method of Herba Bidentis Bipinnatae effective ingredient, comprises the steps：
1）Remove soil and the weeds on spanishneedles herb leaf first, spanishneedles herb leaf tap water wash clean dries in the shade, then using super
Spanishneedles herb leaf is carried out pulverization process by thin mechanical crusher, reaches 1000-2000 mesh, obtains spanishneedles herb leaf powder；
2）According to the weight of spanishneedles herb leaf powder, add the water soaking step 1 of 8 times amount）The spanishneedles herb leaf powder obtaining, exists simultaneously
The cellulase of spanishneedles herb leaf powder weight 3 ‰ is added, adjustment pH is 6-7, temperature is 45 DEG C, mixing speed in reacting by heating kettle
For 30rpm, digest 3hr；The compounding protease of spanishneedles herb leaf weight 3 ‰ is added, adjustment pH is 6-7 after cellulase degradation,
Temperature is 45 DEG C, and mixing speed is 30rpm, digests 3hr；After compounding protease hydrolyzed, processing 4min under 95 DEG C of high temperature makes
Compounding protease inactivation；Centrifugation, obtains enzymolysis solution and Herba Bidentis Bipinnatae slag；
3）Using alkalescence small-micelle water to step 2）In Herba Bidentis Bipinnatae slag, per kilogram Herba Bidentis Bipinnatae slag add 7 liters of alkalescencies little
Micel water；Extract 1.5 hours at a temperature of 20 DEG C, be again separate out extracting solution and Herba Bidentis Bipinnatae slag；
4）Combining step 2）With step 3）Herba Bidentis Bipinnatae slag, obtain mix Herba Bidentis Bipinnatae slag, and mix Herba Bidentis Bipinnatae slag be used as pig feed；
Combining step 2）Enzymolysis solution and step 3）Extracting solution, obtain mixed extract, mixed extract crossed inorganic ceramic microfiltration
Film, inorganic ceramic micro-filtration membrane aperture is 0.1-1 μm, in microfiltration operation, controls the temperature of mixed extract to be 50 DEG C, pressure is
0.3 MPa, obtains micro-filtrate；The ethanol solution being 60% with volumetric concentration again carries out eluting to micro-filtrate, obtains eluent；Will
Eluent carries out concentrating under reduced pressure process, reclaims ethanol, and drying under reduced pressure becomes dry cream to pulverize 60 mesh sieves, obtains Herba Bidentis Bipinnatae and extracts
Thing.
Described alkalescence small-micelle water is using Application No. 201010253226.4, a kind of invention entitled " sky
Method described in the patent of the right eternal making apparatus of alkalescence small-micelle water and its method " prepares, its system
Comprise the following steps as process：Step 1：Water is passed through in making apparatus by water inlet pipe, water sequentially flows through filter and small molecule
Group's water generator, is flowed out by outlet pipe；Step 2：Water flow adjusting valve door on adjustment outlet pipe, by the current in outlet pipe
Amount is adjusted to 20-80mL/min, and the current adjustment that acid-base value adjusts in pipe hollow cavity breaks formula and falls in beading；Step 3：
Container adjusts the outlet water receiving of pipe lower end in acid-base value, you can obtain alkalescence small-micelle water.
Described compounding protease is papain and alkaline protease according to 1:1 weight ratio mixes.
The above-mentioned Herba Bidentis Bipinnatae extract preparing can be used to prepare Herba Bidentis Bipinnatae facial film, and Herba Bidentis Bipinnatae facial film comprises to weigh as follows
The raw material composition of amount number：Herba Bidentis Bipinnatae extract 7；Tender bamboo leaf water 4；Fructus Citri Limoniae juice 3；Mel 0.8；Clabber 4；Vitamin E 0.8；
Jasmin quintessence oil 0.8；Fructus Luffae concentrated solution 2.5；Margarita powder 4；Flour 11.
The manufacture method of Herba Bidentis Bipinnatae facial film is：According to parts by weight, first by Herba Bidentis Bipinnatae extract, Vitamin E, jasmin quintessence oil
It is added in container with Mel, is tuned into pasty state with appropriate distilled water, add clabber, after mix homogeneously, sequentially add Fructus Luffae dense
Contracting liquid, Fructus Citri Limoniae juice, tender bamboo leaf, Margarita powder dough-making powder, stir, obtain facial film serosity, use in 1-3 hour.
The preparation method of described tender bamboo leaf water is：The tender bamboo leaf of fresh harvesting is cleaned, puts into 4～8 times of its weight
Steaming and decocting 30～60 minutes in boiling water, cooling is placed, and obtains tender bamboo leaf water.
The extracting method of Fructus Luffae concentrated solution is：By Fructus Luffae after physical squeezing, filtered with grid cloth, take filtrate, add filter
3-5 times of mass concentration of liquid weight be 40% ethanol as Extraction solvent, be heated to reflux 20-30 minute at 40-50 DEG C, obtain
Extracting solution；After extracting solution is separated through micro-filtration membrane, ultrafilter membrane, nanofiltration membrane respectively, concentrate, obtain Fructus Luffae concentrated solution.
Embodiment 3
The extracting method of Herba Bidentis Bipinnatae effective ingredient, comprises the steps：
1）Remove soil and the weeds on spanishneedles herb leaf first, spanishneedles herb leaf tap water wash clean dries in the shade, then using super
Spanishneedles herb leaf is carried out pulverization process by thin mechanical crusher, reaches 1000-2000 mesh, obtains spanishneedles herb leaf powder；
2）According to the weight of spanishneedles herb leaf powder, add the water soaking step 1 of 10 times amount）The spanishneedles herb leaf powder obtaining, simultaneously
Add the cellulase of spanishneedles herb leaf powder weight 5 ‰ in reacting by heating kettle, adjustment pH is 6-7, temperature is 50 DEG C, stirring speed
Spend for 20rpm, enzymolysis 2hr；The compounding protease of spanishneedles herb leaf weight 5 ‰ is added, adjustment pH is 6- after cellulase degradation
7, temperature is 50 DEG C, and mixing speed is 20rpm, digests 2hr；After compounding protease hydrolyzed, process 2min under 100 DEG C of high temperature
Make compounding protease inactivation；Centrifugation, obtains enzymolysis solution and Herba Bidentis Bipinnatae slag；
3）Using alkalescence small-micelle water to step 2）In Herba Bidentis Bipinnatae slag, per kilogram Herba Bidentis Bipinnatae slag add 8 liters of alkalescencies little
Micel water；Extract 1.5 hours at a temperature of 20 DEG C, be again separate out extracting solution and Herba Bidentis Bipinnatae slag；
4）Combining step 2）With step 3）Herba Bidentis Bipinnatae slag, obtain mix Herba Bidentis Bipinnatae slag, and mix Herba Bidentis Bipinnatae slag be used as pig feed；
Combining step 2）Enzymolysis solution and step 3）Extracting solution, obtain mixed extract, mixed extract crossed inorganic ceramic microfiltration
Film, inorganic ceramic micro-filtration membrane aperture is 0.1-1 μm, in microfiltration operation, controls the temperature of mixed extract to be 50 DEG C, pressure is
0.3MPa, obtains micro-filtrate；The ethanol solution being 60% with volumetric concentration again carries out eluting to micro-filtrate, obtains eluent；To wash
De- liquid carries out concentrating under reduced pressure process, reclaims ethanol, and drying under reduced pressure becomes dry cream to pulverize 60 mesh sieves, obtains Herba Bidentis Bipinnatae extract.
Described alkalescence small-micelle water is using Application No. 201010253226.4, a kind of invention entitled " sky
Method described in the patent of the right eternal making apparatus of alkalescence small-micelle water and its method " prepares, its system
Comprise the following steps as process：Step 1：Water is passed through in making apparatus by water inlet pipe, water sequentially flows through filter and small molecule
Group's water generator, is flowed out by outlet pipe；Step 2：Water flow adjusting valve door on adjustment outlet pipe, by the current in outlet pipe
Amount is adjusted to 20-80mL/min, and the current adjustment that acid-base value adjusts in pipe hollow cavity breaks formula and falls in beading；Step 3：
Container adjusts the outlet water receiving of pipe lower end in acid-base value, you can obtain alkalescence small-micelle water.
Described compounding protease is papain and alkaline protease according to 1:1 weight ratio mixes.
The above-mentioned Herba Bidentis Bipinnatae extract preparing can be used to prepare Herba Bidentis Bipinnatae facial film, and Herba Bidentis Bipinnatae facial film comprises to weigh as follows
The raw material composition of amount number：Herba Bidentis Bipinnatae extract 8；Tender bamboo leaf water 5；Fructus Citri Limoniae juice 4；Mel 1；Clabber 5；Vitamin e1；Jasmine
Quintessence oil 1；Fructus Luffae concentrated solution 3；Margarita powder 5；Flour 12.
The manufacture method of Herba Bidentis Bipinnatae facial film is：According to parts by weight, first by Herba Bidentis Bipinnatae extract, Vitamin E, jasmin quintessence oil
It is added in container with Mel, is tuned into pasty state with appropriate distilled water, add clabber, after mix homogeneously, sequentially add Fructus Luffae dense
Contracting liquid, Fructus Citri Limoniae juice, tender bamboo leaf, Margarita powder dough-making powder, stir, obtain facial film serosity, use in 1-3 hour.
The preparation method of described tender bamboo leaf water is：The tender bamboo leaf of fresh harvesting is cleaned, puts into 4～8 times of its weight
Steaming and decocting 30～60 minutes in boiling water, cooling is placed, and obtains tender bamboo leaf water.
The extracting method of Fructus Luffae concentrated solution is：By Fructus Luffae after physical squeezing, filtered with grid cloth, take filtrate, add filter
3-5 times of mass concentration of liquid weight be 40% ethanol as Extraction solvent, be heated to reflux 20-30 minute at 40-50 DEG C, obtain
Extracting solution；After extracting solution is separated through micro-filtration membrane, ultrafilter membrane, nanofiltration membrane respectively, concentrate, obtain Fructus Luffae concentrated solution.
Applicable cases of the present invention
The facial film that above-described embodiment is obtained tries out to 30 young woman, and 30 experimenter's great majority all have pachylosiies, easily
The used cucumber face pack, egg that be dried, have add honey facial mask, even if evening face notes moisturizing, but or feel not
Good, particularly on working road, the facial skin of the harmful gass more aggravation that vehicle exhaust is discharged is compromised.Through these experimenters
On probation, daily 1-2 time, in general three days effectively, after one week, facial skin all has fine and smooth, glossiness situation.30 experimenters
Effective percentage is 100% although individuality has difference, but facial skin improves or relatively significantly.
Application Example 1
Chen, Nanning City's electrical equipment salesman, its job requirement must carry adornment to go to work daily, and its skin belongs to dryness
Skin, one to autumn and winter season, skin is especially dry, easy peeling, and whole people looks like flipperty-flopperty, and a little spiritual gas does not all have
Have, criticized more than once by boss, allow its worries long time.After introducing by friend, employ the Herba Bidentis Bipinnatae of the present invention
Facial film, continuously employs one week, and skin becomes tender, careful and smooth, and the place of originally peeling slowly becomes full, whole people
Essence put on grand airs.
Application Example 2
Lee so-and-so, 24 years old, the accounting of certain logistics company completed financial statement it is often necessary to work extra shifts or extra hours, and it is complained due to work
Make pressure big, directly emit goose pimples and comedo on the face, used many moneys MASQUE APAISANT HYDRATANT and the pox product that disappears on market, all do not become effective；
Later upon somebody's introduction after, employ the Herba Bidentis Bipinnatae facial film of the present invention, and start to be careful in one's diet, peppery and steam thing is not eaten
With, after continuously using one week, comedo significantly reduces, and goose pimples on the face also slowly eliminates, and Herba Bidentis Bipinnatae facial film of the present invention is described
（Main Function material is flavonoid and polyphenol compound in Herba Bidentis Bipinnatae extract）Toxin can be suppressed to grow, accelerate health
Skin growth, and its on the face skin slowly recover moisture, gradually become smooth, moisten, young beautiful.
Application Example 3
Journey so-and-so, 30 years old, after Silver Sands tourism in the North Sea is returned, the face of whole people was by tanned one layer, and skin on the face for September part
Peeling is dried, introduces by friend, continuously use the Herba Bidentis Bipinnatae facial film of the present invention after one week, facial muscle is full, skin moisturizing,
Gloss, recovery are fine and smooth ruddy.
Claims (6)
1. Herba Bidentis Bipinnatae effective ingredient extracting method it is characterised in that：Comprise the steps：
1）Remove soil and the weeds on spanishneedles herb leaf first, spanishneedles herb leaf tap water wash clean dries in the shade, then using super
Spanishneedles herb leaf is carried out pulverization process by thin mechanical crusher, reaches 1000-2000 mesh, obtains spanishneedles herb leaf powder；
2）According to the weight of spanishneedles herb leaf powder, add the water soaking step 1 of 5-10 times amount）The spanishneedles herb leaf powder obtaining, with
When in reacting by heating kettle add spanishneedles herb leaf powder weight 1 ‰ -5 ‰ cellulase, adjustment pH be 6-7, temperature be 40-50
DEG C, mixing speed is 20-35rpm, digests 2-4hr；The compounding of spanishneedles herb leaf weight 1 ‰ -5 ‰ is added after cellulase degradation
Protease, adjustment pH is 6-7, and temperature is 40-50 DEG C, and mixing speed is 20-35rpm, digests 2-4hr；Compounding protease hydrolyzed
Afterwards, processing 2～5min under 90-100 DEG C of high temperature makes compounding protease inactivation；Centrifugation, obtains enzymolysis solution and Herba Bidentis Bipinnatae slag；
3）Using alkalescence small-micelle water to step 2）In Herba Bidentis Bipinnatae slag, per kilogram Herba Bidentis Bipinnatae slag add 5-8 rise alkalescence
Small-micelle water；Extract 1-2 hour at a temperature of 15-25 DEG C, be again separate out extracting solution and Herba Bidentis Bipinnatae slag；
4）Combining step 2）With step 3）Herba Bidentis Bipinnatae slag, obtain mix Herba Bidentis Bipinnatae slag, and mix Herba Bidentis Bipinnatae slag be used as pig feed；
Combining step 2）Enzymolysis solution and step 3）Extracting solution, obtain mixed extract, mixed extract crossed inorganic ceramic microfiltration
Film, obtains micro-filtrate；The ethanol solution being 60% with volumetric concentration again carries out eluting to micro-filtrate, obtains eluent；By eluent
Carry out concentrating under reduced pressure process, reclaim ethanol, drying under reduced pressure becomes dry cream to pulverize 60 mesh sieves, obtains Herba Bidentis Bipinnatae extract.
2. Herba Bidentis Bipinnatae effective ingredient according to claim 1 extracting method it is characterised in that：Step 2）Described is compounding
Protease is papain and alkaline protease according to 1:1 weight ratio mixes.
3. Herba Bidentis Bipinnatae effective ingredient according to claim 1 extracting method it is characterised in that：Step 4）Described microfiltration
In operation, step 4）In described microfiltration operation, inorganic ceramic micro-filtration membrane aperture is 0.1-1 μm, and the temperature of mixed extract is
40-60 DEG C, pressure is 0.2-0.4 MPa.
4. root of Broussonetiapapyrifera(I)vent effective ingredient according to claim 1 extracting method it is characterised in that：Step 4）Described mixing ghost
Application in terms of feedstuff for the needle grass slag.
5. the Herba Bidentis Bipinnatae extract that the extracting method of the Herba Bidentis Bipinnatae effective ingredient described in claim 1 obtains is in terms of preparing facial film
Purposes.
6. purposes in terms of preparing facial film for the Herba Bidentis Bipinnatae extract according to claim 5 it is characterised in that：Facial film is by such as
The raw material composition of lower parts by weight：Herba Bidentis Bipinnatae extract 5-8；Tender bamboo leaf water 3-5；Fructus Citri Limoniae juice 2-4；Mel 0.5-1；Clabber 3-
5；Vitamin E 0.5-1；Jasmin quintessence oil 0.5-1；Fructus Luffae concentrated solution 2-3；Margarita powder 3-5；Flour 10-12；
The preparation method of described tender bamboo leaf water is：The tender bamboo leaf of fresh harvesting is cleaned, puts into the boiling water of 4～8 times of its weight
Middle steaming and decocting 30～60 minutes, cooling is placed, and obtains tender bamboo leaf water；
The extracting method of described Fructus Luffae concentrated solution is：By Fructus Luffae after physical squeezing, filtered with grid cloth, take filtrate, add
3-5 times of mass concentration of filtrate weight be 40% ethanol as Extraction solvent, be heated to reflux 20-30 minute at 40-50 DEG C,
Obtain extracting solution；After extracting solution is separated through micro-filtration membrane, ultrafilter membrane, nanofiltration membrane respectively, concentrate, obtain Fructus Luffae concentrated solution；
Its manufacture method is：According to parts by weight, first Herba Bidentis Bipinnatae extract, Vitamin E, jasmin quintessence oil and Mel are added to appearance
In device, it is tuned into pasty state with appropriate distilled water, adds clabber, after mix homogeneously, sequentially add Fructus Luffae concentrated solution, Fructus Citri Limoniae juice, tender
Folium Bambusae water, Margarita powder dough-making powder, stir, and obtain facial film serosity, use in 1-3 hour.
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