CN108451815A - A kind of bacterio static itching-relieving composition - Google Patents
A kind of bacterio static itching-relieving composition Download PDFInfo
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- CN108451815A CN108451815A CN201810313358.8A CN201810313358A CN108451815A CN 108451815 A CN108451815 A CN 108451815A CN 201810313358 A CN201810313358 A CN 201810313358A CN 108451815 A CN108451815 A CN 108451815A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of bacterio static itching-relieving compositions, include the ingredient of following mass percent：Herba Hyperici Japonici extract 0.2 6%, Beggarticks extract 0.1 4%, Swamp Mahogany Leaf volatile oil 0.1 4%.Present composition addition Herba Hyperici Japonici extract, Beggarticks extract, Swamp Mahogany Leaf volatile oil are used in compounding, and are played synergistic function between each ingredient, are played strong bacteriostasis efficacy, clearing heat and cooling blood, eliminating dampness is antipruritic, effectively takees good care of skin, skin of getting well.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of bacterio static itching-relieving composition.
Background technology
With rapid development of economy, work, rhythm of life are getting faster, in addition city Air Contamination further adds
The influence of many factors such as play and the undesirable work and rest custom of the lower people of high pressure life, incorrect skin nursing.It is more and more
Per capita by the synthtic price index of the skins such as pruitus, scytitis, skin eczema and dandruff disorder perplex, study carefully
Its reason is caused by skin surface pathogenic infection microorganism.
It is presently commercially available it is common it is antibacterial, antipruritic class product therapeutic effect is effective in short term, but be used for a long time and have prodigious pair
Effect.Such product generally contains hormone constituents, and long-time service can lead to skin dependence, once smearing can be made by stopping using
Its erythema, scorching hot, itch etc. are aggravated more in position stimulates serious symptom.The demand of bacterio static itching-relieving class product is also more invented
Aobvious, urgent need exploitation bacterio static itching-relieving is significant in efficacy, while will not cause the new product of the adverse reactions such as dependence to skin again.
Invention content
The technical problem to be solved in the present invention is to provide a kind of bacterio static itching-relieving compositions.The present composition adds hypericum japonicum
Extract, Beggarticks extract, Swamp Mahogany Leaf volatile oil are used in compounding, and synergistic function is played between each ingredient, are played strong
Strong bacteriostasis efficacy, clearing heat and cooling blood, eliminating dampness is antipruritic, effectively takees good care of skin, skin of getting well.
To achieve the above object, the present invention provides following scheme：
A kind of bacterio static itching-relieving composition, includes the ingredient of following mass percent：Herba Hyperici Japonici extract 0.2-6%, Bidens bipinnata
Careless extract 0.1-4%, Swamp Mahogany Leaf volatile oil 0.1-4%.
Further, the composition includes the ingredient of following mass percent：Herba Hyperici Japonici extract 0.5-5.5%, ghost
Needle grass extract 0.2-3.8%, Swamp Mahogany Leaf volatile oil 0.2-3.5%.
Further, the composition includes the ingredient of following mass percent：Herba Hyperici Japonici extract 3%, beggar-ticks
Extract 2.5%, Swamp Mahogany Leaf volatile oil 1.8%.
The preparation method of a kind of bacterio static itching-relieving composition, the base Huang extract is：By hypericum japonicum clean dry, crushed
20-40 mesh sieves, according to solid-liquid ratio 1:After 70-95% ethyl alcohol immersion 10-30min is added in 10-20, the ultrasonic extraction at 50-80 DEG C
1-1.5h, filters, and filtrate is concentrated by evaporation through Rotary Evaporators.
A kind of bacterio static itching-relieving composition, the preparation method of the Beggarticks extract are：By beggar-ticks clean dry, crush
20-40 mesh sieve is crossed, according to solid-liquid ratio 1:5-15 addition 70-95% ethyl alcohol, refluxing extraction 3 times at 50-70 DEG C, each 1-2h,
Merging filtrate after filtering, filtrate are concentrated under reduced pressure through Rotary Evaporators, then in 60 DEG C of vacuum drying.
The preparation method of a kind of bacterio static itching-relieving composition, the Swamp Mahogany Leaf volatile oil is：Eucalyptus robusta blade is cut into 1-
3cm2Fragment, be placed in volatile oil extractor and connect the conventional steam way of distillation and continuously extract 5-7h, collected grease is suspended
Liquid is extracted with ether, and gained volatile oil is dehydrated with anhydrous sodium sulfate after low temperature recycling ether, is preserved at 4 DEG C.
Bacterio static itching-relieving composition provided by the invention can be used for the preparation of cosmetics, wherein the bacterio static itching-relieving composition
It can be used as preparation of the additive for bacterio static itching-relieving shower cream.
The present invention also provides a kind of bacterio static itching-relieving shower creams, further include the component of following mass percent：Glycerine bay
Acid esters 0.5-1.5%, sodium lauroyl glutamate 1-4%, sodium lauroyl sarcosine 3-8%, cocounut oil acyl both sexes base diethyl acid disodium
5-8%, Cocoamidopropyl betaine 1-3%, citric acid 0.01-0.03%, Phenoxyethanol 0.3-0.8%, hydroxybenzoic acid
Ester 0.1-0.5%, hydroxyethyl cellulose 0.1-0.3%, vitamin E 0.1-0.3%, sodium chloride 0.1-0.5%, more than deionized water
Amount.
Compared with prior art, the invention has the advantages that：
The present invention by the way that Herba Hyperici Japonici extract, Beggarticks extract, Swamp Mahogany Leaf volatile oil are used in compounding, respectively at point it
Between play synergistic effect, preferably can carry out inhibition removing to remaining bacterium on skin, at the same also have clearing heat and cooling blood,
Healthy skin is presented to effectively take good care of skin in the antipruritic effect of eliminating dampness.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Involved each ingredient is described as follows in composition of the present invention：
Hypericum japonicum (Hypericumjaponicum Thunb.) is that the drying of Guttiferae hypericum hypericum japonicum is complete
Grass contains the chromocor compounds such as abundant rutin, quercitin, isoquercitrin.Chromocor compound, which has, to reduce blood pressure, protects cardiac muscle
Damage, enhancing cellular immune function, antibacterial anti-inflammatory and the bioactivity such as anti-oxidant.
Beggar-ticks Bi dens bi pi nnata L. also known as grass, a caecum grass etc., it is bitter in taste, flat, it is nontoxic, it is chrysanthemum
The herb of section plant beggar-ticks etc..Find that beggar-ticks contains alkaloid through modern study, saponin, glycosides displayed, tannin, cauline leaf is containing volatilization
Oil, tannin, choline etc..The ethanol extract of beggar-ticks has good bacteriostasis to gram-positive bacterium in vitro, to golden yellow
Color staphylococcus and fungi have inhibiting effect, still there is anti-allergic effects in addition, have clearing heat and cooling blood, removing toxic substances, detumescence, dissipate stasis of blood row
The functions such as purulence, eliminating dampness is antipruritic.
Swamp Mahogany Leaf is the leaf of dicotyledon Myrtaceae eucalyptus robusta (Eucalyptus robusta Smith), taste
It is pungent, bitter, it is cool in nature, have dispelling wind deliver, be clearing heat and detoxicating, expelling phlegm and arresting coughing, antipruritic desinsection the effect of.Great Ye is by being that South China is civil
Common Chinese herbal medicine, leaf water decoction have the antipruritic effect of clearing heat and detoxicating, anti-inflammatory analgetic, anti-corrosion, and total volatile oil can be used for treating
The diseases such as influenza, the infection of the upper respiratory tract and skin disease.It is reported according to documents and materials, eucalyptus oil has antipyretic anti-inflammatory and resists
Bacterium corrosion-resistant acts on.
Embodiment 1
A kind of bacterio static itching-relieving shower cream, includes the following components'mass percentage：Herba Hyperici Japonici extract 3%, beggar-ticks carry
Take object 2.5%, Swamp Mahogany Leaf volatile oil 1.8%, glycerol monolaurate 1%, sodium lauroyl glutamate 2.5%, lauroyl flesh ammonia
Sour sodium 5.5%, cocounut oil acyl both sexes base diethyl acid disodium 6.5%, Cocoamidopropyl betaine 2%, citric acid 0.02%, benzene oxygen
Ethyl alcohol 0.55%, hydroxybenzoate 0.3%, hydroxyethyl cellulose 0.2%, vitamin E 0.2%, sodium chloride 0.3%, go from
Sub- water surplus.
Embodiment 2
A kind of bacterio static itching-relieving shower cream, includes the following components'mass percentage：Herba Hyperici Japonici extract 0.5%, beggar-ticks
Extract 0.2%, Swamp Mahogany Leaf volatile oil 0.2%, glycerol monolaurate 0.8%, sodium lauroyl glutamate 1.5%, lauroyl
Sodium sarcosinate 4%, cocounut oil acyl both sexes base diethyl acid disodium 6%, Cocoamidopropyl betaine 1.5%, citric acid 0.01%, benzene
Oxyethanol 0.5%, hydroxybenzoate 0.2%, hydroxyethyl cellulose 0.15%, vitamin E 0.15%, sodium chloride 0.15%,
Deionized water surplus.
Embodiment 3
A kind of bacterio static itching-relieving shower cream, includes the following components'mass percentage：Herba Hyperici Japonici extract 5.5%, beggar-ticks
Extract 3.8%, Swamp Mahogany Leaf volatile oil 3.5%, glycerol monolaurate 1.5%, sodium lauroyl glutamate 3%, lauroyl flesh
Propylhomoserin sodium 7%, cocounut oil acyl both sexes base diethyl acid disodium 7%, Cocoamidopropyl betaine 2.5%, citric acid 0.03%, benzene oxygen
Ethyl alcohol 0.6%, hydroxybenzoate 0.4%, hydroxyethyl cellulose 0.3%, vitamin E 0.25%, sodium chloride 0.4%, go from
Sub- water surplus.
Embodiment 4
A kind of bacterio static itching-relieving shower cream, includes the following components'mass percentage：Herba Hyperici Japonici extract 0.2%, beggar-ticks
Extract 0.1%, Swamp Mahogany Leaf volatile oil 0.1%, glycerol monolaurate 0.5%, sodium lauroyl glutamate 1%, lauroyl flesh
Propylhomoserin sodium 3%, cocounut oil acyl both sexes base diethyl acid disodium 5%, Cocoamidopropyl betaine 1%, citric acid 0.01%, benzene oxygen second
Alcohol 0.3%, hydroxybenzoate 0.1%, hydroxyethyl cellulose 0.1%, vitamin E 0.1%, sodium chloride 0.1%, deionized water
Surplus.
Embodiment 5
A kind of bacterio static itching-relieving shower cream, includes the following components'mass percentage：Herba Hyperici Japonici extract 6%, beggar-ticks carry
Take object 4%, Swamp Mahogany Leaf volatile oil 4%, glycerol monolaurate 1.5%, sodium lauroyl glutamate 4%, sodium lauroyl sarcosine
8%, cocounut oil acyl both sexes base diethyl acid disodium 8%, Cocoamidopropyl betaine 3%, citric acid 0.03%, Phenoxyethanol
0.8%, hydroxybenzoate 0.5%, hydroxyethyl cellulose 0.3%, vitamin E 0.3%, sodium chloride 0.5%, more than deionized water
Amount.
A kind of preparation methods of bacterio static itching-relieving shower cream of embodiment 1-5 are：(1) by hydroxyethyl cellulose, citric acid, hydroxyl
Benzoic ether, deionized water are mixed and heated to 75 DEG C, and A phases are made；(2) by above-mentioned composition, glycerol monolaurate, lauroyl paddy
Propylhomoserin sodium, sodium lauroyl sarcosine, vitamin E, cocounut oil acyl both sexes base diethyl acid disodium, Cocoamidopropyl betaine stir successively
It mixes and A phases, insulated and stirred 20min is added；(3) 45 DEG C are cooled to, Phenoxyethanol, sodium chloride is added, stirs evenly, is discharged.
Comparative example 1
Difference lies in Herba Hyperici Japonici extract is not added with embodiment 1.
Comparative example 2
Difference lies in Beggarticks extract is not added with embodiment 1.
Comparative example 3
Difference lies in Swamp Mahogany Leaf volatile oil is not added with embodiment 1.
Comparative example 4
Difference lies in the acne-removing composition includes following mass percent ingredient with embodiment 1：Herba Hyperici Japonici extract
6.1%, Beggarticks extract 4.1%, Swamp Mahogany Leaf volatile oil 4.1%.
Efficacy validation
Bacteriostasis efficacy is verified
For trying strain：Staphylococcus aureus, Escherichia coli, propionibacterium acnes
Culture medium and condition of culture：Nutrient agar (36 ± 1 DEG C of incubator 48 ± 2h of culture, for golden yellow grape
Coccus, Escherichia coli culture), cooked meat medium (be used for propionibacterium acnes culture).
Test method：With reference to National Standard of the People's Republic of China GB15797-2002, " Disposable Sanitary Accessory is defended
Appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method " in raw standard ".
Formula：X=(A-B)/A × 100%
In formula:X --- bacteriostasis rate, %
A --- control sample averagely recycles bacterium colony；
B --- test specimen averagely recycles bacterium colony.
Bacteriostasis efficacy is evaluated：Efficacy assessments divide three-level:It is effective, effective and invalid, it as a result see the table below 1.
Table 1
| Group/strain | Escherichia coli | Staphylococcus aureus | Propionibacterium acnes |
| Embodiment 1 | It is effective | It is effective | Effectively |
| Embodiment 2 | It is effective | Effectively | It is effective |
| Embodiment 3 | It is effective | It is effective | It is effective |
| Embodiment 4 | It is effective | Effectively | It is effective |
| Embodiment 5 | It is effective | It is effective | It is effective |
| Comparative example 1 | Effectively | Effectively | Effectively |
| Comparative example 2 | Effectively | Effectively | Effectively |
| Comparative example 3 | Effectively | Effectively | Effectively |
| Comparative example 4 | Effectively | Effectively | Effectively |
Composition Herba Hyperici Japonici extract, Beggarticks extract, the Swamp Mahogany Leaf of the present invention known to the data analysis of table 1 is waved
Hair oil compounding has synergistic function, can play significant fungistatic effect.
Efficacy validation
1000 volunteers are selected, per each 100 triers of test group.It is prepared using embodiment 1-5, comparative example 1-4
Shower cream, participant respectively use 1 time, persistently use 1 month daily.Other any skin-protection products must not be used in experimentation,
And subject has been fully completed verification process, and experimental result is shown in Table 2, and effect divides three grades：
Antipruritic effect is apparent：Antipruritic effect is apparent, skin not itch；
Antipruritic effect is general：Antipruritic effect is general, and skin still has pruritis；
Antipruritic effect unobvious：For pruitus without improvement, pruitus situation and difference before are little, without apparent sense after
Feel.
2 each embodiment of table, comparative example using effect
It is on probation to majority that the shower cream that the embodiment of the present invention is provided is can be seen that from the result of the self-assessment of trier
Person's skin has the effect of preferably improving skin itch, antipruritic, realizes the purpose of bacterio static itching-relieving.
The present invention is described by way of example above, but the present invention is not limited to above-mentioned specific embodiment, all to be based on
Any changes or modifications that the present invention is done belong to the scope of protection of present invention.
Claims (8)
1. a kind of bacterio static itching-relieving composition, which is characterized in that include the ingredient of following mass percent：Herba Hyperici Japonici extract 0.2-
6%, Beggarticks extract 0.1-4%, Swamp Mahogany Leaf volatile oil 0.1-4%.
2. composition as described in claim 1, which is characterized in that include the ingredient of following mass percent：Hypericum japonicum extracts
Object 0.5-5.5%, Beggarticks extract 0.2-3.8%, Swamp Mahogany Leaf volatile oil 0.2-3.5%.
3. composition as claimed in claim 2, which is characterized in that include the ingredient of following mass percent：Hypericum japonicum extracts
Object 3%, Beggarticks extract 2.5%, Swamp Mahogany Leaf volatile oil 1.8%.
4. composition as described in any one of claims 1-3, which is characterized in that the preparation method of the Herba Hyperici Japonici extract
For：By hypericum japonicum clean dry, 20-40 mesh sieve is crushed, according to solid-liquid ratio 1:10-20 is added 70-95% ethyl alcohol and impregnates 10-
After 30min, the ultrasonic extraction 1-1.5h at 50-80 DEG C is filtered, and filtrate is concentrated by evaporation through Rotary Evaporators.
5. composition as described in any one of claims 1-3, which is characterized in that the preparation method of the Beggarticks extract
For：By beggar-ticks clean dry, 20-40 mesh sieve is crushed, according to solid-liquid ratio 1:70-95% ethyl alcohol is added in 5-15, in 50-70 DEG C
Lower refluxing extraction 3 times, each 1-2h, merging filtrate after filtering, filtrate is concentrated under reduced pressure through Rotary Evaporators, then in 60 DEG C of vacuum
Drying.
6. composition as described in any one of claims 1-3, which is characterized in that the preparation method of the Swamp Mahogany Leaf volatile oil
For：Eucalyptus robusta blade is cut into 1-3cm2Fragment, be placed in volatile oil extractor and connect the conventional steam way of distillation and continuously extract
5-7h, collected grease suspension are extracted with ether, and gained volatile oil is dehydrated with anhydrous sodium sulfate after low temperature recycling ether, in
It is preserved at 4 DEG C.
7. composition as claimed in any one of claims 1 to 6, it is characterised in that can be used for the preparation of cosmetics.
8. composition as claimed in claim 7, which is characterized in that the composition can be used as additive and be washed one's hair for bacterio static itching-relieving
The preparation of bath lotion.
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| CN201810313358.8A CN108451815A (en) | 2018-04-09 | 2018-04-09 | A kind of bacterio static itching-relieving composition |
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| CN201810313358.8A CN108451815A (en) | 2018-04-09 | 2018-04-09 | A kind of bacterio static itching-relieving composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7569540B1 (en) | 2023-05-16 | 2024-10-18 | コタ株式会社 | Itch suppressant and cleansing composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673328A (en) * | 2005-04-20 | 2005-09-28 | 王浩贵 | Spanishneedles herb detergent |
| CN106473995A (en) * | 2016-12-14 | 2017-03-08 | 杨攀 | The extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film |
-
2018
- 2018-04-09 CN CN201810313358.8A patent/CN108451815A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673328A (en) * | 2005-04-20 | 2005-09-28 | 王浩贵 | Spanishneedles herb detergent |
| CN106473995A (en) * | 2016-12-14 | 2017-03-08 | 杨攀 | The extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film |
Non-Patent Citations (1)
| Title |
|---|
| 张齐明等: "《药用植物化妆品》", 31 May 1995, 华南理工大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7569540B1 (en) | 2023-05-16 | 2024-10-18 | コタ株式会社 | Itch suppressant and cleansing composition |
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