CN105456053B - Permanent hairdye prepared by a kind of dyestuff and enzyme by natural botanical source - Google Patents
Permanent hairdye prepared by a kind of dyestuff and enzyme by natural botanical source Download PDFInfo
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- CN105456053B CN105456053B CN201510182835.8A CN201510182835A CN105456053B CN 105456053 B CN105456053 B CN 105456053B CN 201510182835 A CN201510182835 A CN 201510182835A CN 105456053 B CN105456053 B CN 105456053B
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- 102000004190 Enzymes Human genes 0.000 title claims abstract description 47
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 47
- 239000001024 permanent hair color Substances 0.000 title claims abstract description 30
- 239000000975 dye Substances 0.000 title claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 90
- 238000001694 spray drying Methods 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 102000006995 beta-Glucosidase Human genes 0.000 claims description 30
- 108010047754 beta-Glucosidase Proteins 0.000 claims description 30
- 239000007788 liquid Substances 0.000 claims description 26
- RJWJHRPNHPHBRN-FKVJWERZSA-N aucubin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2C(CO)=C[C@@H](O)[C@@H]2C=CO1 RJWJHRPNHPHBRN-FKVJWERZSA-N 0.000 claims description 25
- UTDFQMAXCUGNJR-UHFFFAOYSA-N aucubin Natural products OCC1OC(Oc2ccoc2C3C(O)CCC3O)C(O)C(O)C1O UTDFQMAXCUGNJR-UHFFFAOYSA-N 0.000 claims description 25
- 229920001577 copolymer Polymers 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 25
- 229910021641 deionized water Inorganic materials 0.000 claims description 25
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 25
- 238000004043 dyeing Methods 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 23
- 230000001804 emulsifying effect Effects 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 22
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 20
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 17
- 239000004902 Softening Agent Substances 0.000 claims description 16
- 239000007787 solid Substances 0.000 claims description 16
- 238000004321 preservation Methods 0.000 claims description 15
- 239000006185 dispersion Substances 0.000 claims description 14
- 229940008099 dimethicone Drugs 0.000 claims description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 12
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 10
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 10
- 239000002304 perfume Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 235000010265 sodium sulphite Nutrition 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 8
- 238000004945 emulsification Methods 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 210000002615 epidermis Anatomy 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 238000010008 shearing Methods 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 101710099628 Beta-glucosidase 1 Proteins 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 244000132059 Carica parviflora Species 0.000 claims description 3
- 235000014653 Carica parviflora Nutrition 0.000 claims description 3
- -1 methyl-isothiazol Quinoline ketone Chemical class 0.000 claims description 3
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 150000002338 glycosides Chemical class 0.000 claims description 2
- 108700019599 monomethylolglycine Proteins 0.000 claims description 2
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 2
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- 239000001069 triethyl citrate Substances 0.000 claims description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000013769 triethyl citrate Nutrition 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 240000006413 Prunus persica var. persica Species 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 239000000118 hair dye Substances 0.000 abstract description 30
- 238000005516 engineering process Methods 0.000 abstract description 7
- 239000003094 microcapsule Substances 0.000 abstract description 7
- 239000000835 fiber Substances 0.000 abstract description 5
- 239000001301 oxygen Substances 0.000 abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 150000001448 anilines Chemical class 0.000 abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 238000004040 coloring Methods 0.000 abstract description 3
- 239000000843 powder Substances 0.000 abstract description 3
- 238000003860 storage Methods 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 230000001473 noxious effect Effects 0.000 abstract description 2
- 239000003643 water by type Substances 0.000 description 24
- 239000002253 acid Substances 0.000 description 9
- 235000005979 Citrus limon Nutrition 0.000 description 8
- 244000131522 Citrus pyriformis Species 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 7
- 239000006260 foam Substances 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 102000005575 Cellulases Human genes 0.000 description 6
- 108010084185 Cellulases Proteins 0.000 description 6
- 125000005395 methacrylic acid group Chemical class 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 230000037308 hair color Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- BACWCXKATFIVFS-JQCXWYLXSA-N (1r,4ar,5s,7as)-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1,5-diol Chemical compound C1=CO[C@@H](O)[C@@H]2C(CO)=C[C@@H](O)[C@@H]21 BACWCXKATFIVFS-JQCXWYLXSA-N 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000555268 Dendroides Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000208060 Lawsonia inermis Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001499733 Plantago asiatica Species 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 240000003152 Rhus chinensis Species 0.000 description 1
- 235000014220 Rhus chinensis Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 231100000403 acute toxicity Toxicity 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
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- 238000009792 diffusion process Methods 0.000 description 1
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- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
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- 229910021645 metal ion Inorganic materials 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention relates to permanent hairdyes prepared by a kind of dyestuff by natural botanical source and enzyme, it is by following I dose（Paste, pH 6~10）, II dose（Pulvis）Two components are constituted.I dose, II dose provides dyestuff and enzyme respectively, and brown is generated after mixing and is precipitated to black dendritic, hair can be dyed to brown, black.The permanent hair dyestuff and hair fiber adhesion are strong, and natural in color is non-stimulated to skin.Wherein II dose uses spray drying process microcapsules technology, enzyme is efficiently solved because property is vivaciously vulnerable to the influence of the environmental factors such as light, heat, oxygen, humidity and pH value, and lead to the problem that stability is poor, shelf life is short, made enzyme powder agent has good functional character, storage is stablized, easy to use.Hair dye category permanent hairdye of the present invention is free of phenyl amines noxious material, harmless, and the substance toxic to human body will not be generated in hair dye, very safe, and coloring is good.
Description
Technical field
The invention belongs to hair dyeing cosmetic technical field, more particularly to prepared by a kind of dyestuff and enzyme by natural botanical source
Permanent hairdye.
Background technology
Hair dyeing cosmetic refers to the chemical everyday articles that can change hair color.Hair dyeing is actually hair dye from hair table
The interfacial reactions such as the outermost contact wetting of skin, absorption start, and then reach hair epithelium and head by the complex of cell membrane
Hair marrow makes its generations be impregnated with, diffusion phenomena, different with situation and " polymerization " occurs and reacts, and is acted to hair and hair is made to change
Become color, sees Fig. 1.Different by the position of dyeing from hair dyeing mechanism, hair dye can classify as shown in Figure 2.By dyeing
Firmness can be divided into temporary, semipermanent and permanent three classes；By the form of product, and liquid, emulsus, cream can be divided into
Shape, powdery, shampoo type etc. are several.The persistence of time on hair is typically trapped in color and luster after hair dyeing to be classified simultaneously
Determine its purposes.
Permanent hairdye occupies 70~80% in entirely hair dyeing cosmetic product, its active ingredient can penetrate into the end
Stable larger dye molecule is formed in the internal medula of hair, is closed in hair fiber, is made to play lasting hair dyeing
With can generally keep 1~3 month.Mechanism can be sketched：Inside small molecule dyes color developing agent → infiltration hair quality → oxidized dose of oxygen
Change → carry out condensation reaction with couplant and generate macromolecular dyestuff → and is locked inside hair quality → is formed persistence hair dyeing.
Permanent hair dye is mostly oxidized form hair dyeing cosmetic, generally is double-formulation, is constituted based on color developing agent and couplant
Hair dyeing I agent and the II agent that is constituted with oxidant form.Progress is separated when production is prepared for two doses, in use, two doses are mixed,
Infiltration hair is coated to be dyed.Research confirms that oxidative hair dyes have scalp certain damage, and toxicity is big, is easy to cause
Skin generates the senses of discomfort such as redness, shouting pain, is used for a long time and even causes cancer.
How to develop the hair dye that safety, irritation are low, have no toxic side effect has had attracted increasing attention, and develops day
The hair dyed agent of right plant origin active constituent is of great significance.China cosmetics expert also to traditional Chinese medicine Chinese gall,
The fleece-flower root, hematoxylin, Semen sesami nigrum and black soya bean etc. contaminate black active constituent and are studied extensively, to develop botanical hair dye new product
It lays a good foundation, application at present is the most successfully mignonettetree, hair dye made of extra large Na powder, dedicated for the dye of brown hair
Color.
The dyestuff that the present invention introduces is the aucubin of natural botanical source, is the Chinese medicines such as Cortex Eucommiae, Asiatic plantain, glutinous rehmannia
One of active ingredient, the predominantly industries such as medicine, daily-use chemical industry and feed are applied.Aucubin is white powder or knot
Crystalline substance, molecular formula C15H22O9, molecular weight 346.33.Fusing point is 181 DEG C, is dissolved in ethyl alcohol, does not dissolve in ether, chloroform, benzene and stone
Oily ether, acute toxicity pharmacological evaluation show that it is almost nontoxic.
The glycosidic bond for the aucubin being widely present in Chinese herbal medicine is easily broken, and can be decomposed by diluted acid and enzyme, raw
At aucubin aglycon, sugar and other catabolites, color products are generated to be reacted with amino acid, such as table in fresh Cortex Eucommiae
Skin was white originally, and processed " sweating " becomes black afterwards, and root skin is in yellow-white when radix scrophulariae is excavated, after drying it is intradermal it is tacky simultaneously
Become corvinus, these phenomenons are all related with the degradation of aucubin.Chun In Koo etc. have studied pH using reversed-phase HPLC
The influence of value, ionic strength, metal ion to aucubin finds that aucubin being capable of fast degradation generation in strong acid
Brown precipitate.Research shows that aucubin itself cannot be combined with protein, but there is energy and albumen in beta-glucosidase
Covalent bond.According to its dosage difference, produces brown and precipitated to black dendritic, this precipitation and hair fiber attachment
Strong, the natural in color of property, it is non-stimulated to skin, belong to permanent hair dyestuff.
The enzyme that the present invention introduces is the beta-glucosidase of natural botanical source.Li Yang etc. has found the enzyme of separate sources to peach
The degradation of leaf coral glycosides is different, and the activity of the beta-glucosidase in some kind subclass Chinese medicines is more than from microbial fermentation
The activity of the beta-glucosidase reference substance of acquisition is high.And beta-glucosidase enzymatic property is active, stability is poor, be vulnerable to light,
The influence of the environmental factors such as heat, oxygen, humidity and pH value.
Using spray drying process microcapsules technology, beta-glucosidase is allowed to be embedded in methacrylic acid and ethyl acrylate
(1:1) spray-dried that microcapsules pulvis is made in aqueous copolymer dispersion (polymer content 30%), environment is reduced or avoided
Influence of the factor to the stability of beta-glucosidase, beta-glucosidase obtained have good functional character, storage steady
It is fixed, it is easy to use, the case where pH is more than 5.5 can quick release beta-glucosidase, storage to beta-glucosidase and
Using all with great practical significance.The principle of spray drying process microcapsules technology can be understood as wall material formed it is a kind of netted
Structure plays the role of screening.Small molecule object such as water, due to small, the effect through heat can be removed successfully, and molecular volume
Larger heartwood is then stranded in net.In the curing process, although the temperature of hot-air may be very high, since water is from wall material
Middle rapid evaporation is to ensure that heartwood temperature is less than 100 DEG C.Meanwhile atomizing particle is exposed to the time in hot-air at most not
More than more than ten seconds, so the method is also suitable for the microencapsulation of heat-sensitive material.
The permanent hairdye prepared using above method can effectively solve some disadvantages of botanical hair dye generally existing,
If hair dye ingredient is unstable, dye-uptake is not high, and dyeing time is long, these problems directly affect the dyeing effect of natural hair dye
Fruit.Hair dye category permanent hairdye of the present invention is free of phenyl amines noxious material, harmless, and hair dye
In will not generate the substance toxic to human body, it is very safe, and coloring is good.
Invention content
The purpose of the present invention is to provide permanent hairdyes prepared by a kind of dyestuff by natural botanical source and enzyme, should
The dyestuff of hair dye is aucubin, and enzyme is the beta-glucosidase prepared using spray drying process microcapsules technology, is prepared
The hair dye colouring gone out is permanent hairdye naturally, hair dyeing effect is ideal.
Permanent hairdye prepared by a kind of dyestuff and enzyme by natural botanical source of the present invention, it is characterised in that it is
It is made of two following I agent (paste, pH 6~10), II agent (pulvis) components：
(1) I agent includes following components by weight percentage：Aucubin 16~30%, hydroxyethyl cellulose 3~6%,
Glycerine 2~4%, dimethicone 1~2%, soluble perfume 0.1~0.4%, preservative 0~0.3%, balance deionized water
It supplies, with 10% potassium hydroxide tune pH to 6~10；
(2) II agent is by beta-glucosidase 1~10%, sodium sulfite 0~0.1%, methacrylic acid and ethyl acrylate
(1:1) aqueous copolymer dispersion (polymer content 30%) 50~60%, triethyl citrate 1~2%, mono stearate glyceryl ester
0.5~1%, Tween-80 0.5~1.5%, balance deionized water is supplied, and manufactured suspension is spray-dried to be made.
The present invention provides the production methods of above-mentioned hair dye：
(1) preparation method of I agent is：With the hydroxyethyl cellulose of deionized water swelling 3~6%, 2~4% glycerine are added,
1~2% dimethicone, 16~30%, 0.1~0.4% soluble perfume of aucubin, 0~0.3% preservative, surplus
Deionized water is supplied, and with 10% potassium hydroxide tune pH to 6~8, stirs 15~20min, discharging；
(2) II agent preparation method is：The deionized water for accounting for total amount of deionized water 45% is heated to 70~80 DEG C, lemon is added
Lemon triethylenetetraminehexaacetic acid ester 1~2%, mono stearate glyceryl ester 0.5~1%, Tween-80 0.5~1.5%, high speed emulsification shearing, at this time
The solid content of emulsifying liquid about 15%, as foam excessively then will can account for total amount of deionized water in right amount plus dimethicone defoaming
25% deionized water is added into the emulsifying liquid, stirs to room temperature, which is poured into 50~60% methyl
Acrylic acid and ethyl acrylate (1:1) aqueous copolymer dispersion (polymer content 30%), moderate-speed mixer, then will be total with accounting in advance
Enzyme prepared by the beta-glucosidase 1~10% of the deionized water dissolving of amount of deionized water 30%, sodium sulfite 0~0.1%
Liquid pours into methacrylic acid and ethyl acrylate (1:1) copolymer solution and stir 20~50min (300~1000r/min, 30
~45 DEG C), the solid content of emulsifying liquid about 25% at this time.Emulsion spray drying obtains II agent, the condition of spray drying
For：80~180 DEG C of inlet air temperature, 50~120 DEG C of leaving air temp.
Aucubin, beta-glucosidase are prepared using common extracting method from plant material, are preferentially made
It is extracted with water or alcohol.In actual production, aucubin, beta-glucosidase can be purchased from suppliers from plant original
The commercial prod for expecting extraction, to save cost, the preferred purity 60~80% of aucubin, beta-glucosidase can
Select thick enzyme, specific activity of enzyme preferably 20~50U/mg, more preferable 30~40U/mg.
The mass ratio 1 of beta-glucosidase and aucubin in hair dye:1~1:10.
The mass ratio of the enzyme activity of beta-glucosidase and aucubin is 2~10U in hair dye：1mg can will be white
Hair dyes brown；The mass ratio of the enzyme activity and aucubin that need beta-glucosidase is 8~20U：1mg can be by white hair
Dye black.
Preservative is alkaline preservative methylisothiazolinone or sodium hydroxy methyl glycinate, usage amount is respectively 0~
0.01% or 0.2~0.4%.
Methacrylic acid and ethyl acrylate (1:1) aqueous copolymer dispersion (polymer content 30%) can direct purchaser
Product product such as Utech L30D-55；Or buy methacrylic acid and ethyl acrylate (1:1) copolymer, then it is poly- by 30%
It closes object content, 10%1mol/L sodium hydroxide solutions, 60% deionized water and is configured to methacrylic acid and ethyl acrylate (1:1)
Aqueous copolymer dispersion (polymer content 30%).
The present invention provides the application methods of above-mentioned hair dye：I agent, II agent are uniformly mixed, 40~50 DEG C of heat preservations about 20
~30min, while often being opened the hair scale piece of hair epidermis with softening agent using hairdressing, it is washed with water after 10~15min
Softening agent is removed, then the mixture by I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, and washing is clean i.e.
Complete dyeing.
The present invention has the following technical effect that：
1. the dyestuff of the present invention is the aucubin of natural botanical source, substantially harmless to the human body, in β-grape
It can be with albumen covalent bond, producible brown to black dendroid different according to beta-glucosidase enzyme dosage under glucosides enzyme effect
Polymer precipitates, and this precipitation and hair fiber adhesion are strong, and natural in color is non-stimulated to skin, belongs to impermeant dye；
2. the spray drying process microcapsules technology that the beta-glucosidase of the present invention uses, this technology can make beta-glucosidase
The stability of enzyme improves the shelf life requirement for meeting hair dye, and because it can quick release under conditions of pH is more than 5.5
Beta-glucosidase so that beta-glucosidase has good functional character, bin stability, ease of use；
3. the present invention is a kind of dyestuff and enzyme preparation permanent hairdye of natural botanical source, phenyl amines Toxic is free of
Matter is made of two I agent (paste, pH 6~10), II agent (pulvis) components.I agent, II agent are after evenly mixing, micro- in II agent
Capsulated beta-glucosidase releases because of microcapsules rupture under the conditions of environment pH is more than 5.5, makes I agent immediately
In aucubin degradation and with albumen covalent bond, generate brown to black dendritic precipitate, it is this precipitation and
Hair fiber adhesion is strong, and natural in color is non-stimulated to skin；
4. the present invention prepares the hair dye of two kinds of colors, beta-glucosidase by the different amounts of dyestuff of the same race and enzyme
Enzyme activity and aucubin mass ratio be 2~10U：White hair can be dyed brown by 1mg；The enzyme activity of beta-glucosidase
The mass ratio of power and aucubin is 8~20U：White hair can be dyed black by 1mg.
Description of the drawings
Fig. 1：Effect of the hair dye to hair.
Fig. 2：The type and hair dyeing mechanism of hair dye.
Specific implementation mode
Technical scheme of the present invention is described further with reference to embodiment, but protection scope of the present invention and unlimited
In this.
Embodiment 1
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 4g with 66.2g deionized waters, 3g glycerine, 1.5g dimethyl-silicons is added
Oil, 25g aucubins (purity 60%), 0.1g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% potassium hydroxide
PH to 8 is adjusted, 15~20min, discharging are stirred.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 2.9g beta-glucosidases (enzyme
Rate activity is 40U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, dyes
Brown.
Embodiment 2
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 4g with 64.9g deionized waters, 3g glycerine, 1.8g dimethyl-silicons is added
Oil, 26g aucubins (purity 60%), 0.1g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% potassium hydroxide
PH to 8.5 is adjusted, 15~20min, discharging are stirred.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 3.8g beta-glucosidases (enzyme
Rate activity is 30U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, hair
Dye brown.
Embodiment 3
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 4g with 65.6g deionized waters, 2.5g glycerine, 1.5g dimethyl is added
Silicone oil, 26g aucubins (purity 60%), 0.2g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% hydroxide
Potassium tune pH to 7 stirs 15~20min, discharging.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 6.5g beta-glucosidases (enzyme
Rate activity is 30U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, hair
Dye black.
Embodiment 4
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 3.5g with 73.1g deionized waters, 2.5g glycerine, 1.5g diformazans is added
Base silicone oil, 19g aucubins (purity 80%), 0.2g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% hydrogen-oxygen
Change potassium tune pH to 9, stirs 15~20min, discharging.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 4.7g beta-glucosidases (enzyme
Rate activity is 40U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, hair
Dye black.
Embodiment 5
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 3.5g with 72.8g deionized waters, 2.5g glycerine, 1.8g diformazans is added
Base silicone oil, 19g aucubins (purity 80%), 0.2g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% hydrogen-oxygen
Change potassium tune pH to 7.5, stirs 15~20min, discharging.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 3.9g beta-glucosidases (enzyme
Rate activity is 30U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, hair
Dye brown.
Embodiment 6
Permanent hairdye prepared by the dyestuff and enzyme of the natural botanical source of the present embodiment is by two I agent, II agent components
It constitutes, it is specific as follows：
The preparation of I agent：It is swollen the hydroxyethyl cellulose of 3.5g with 71.4g deionized waters, 3g glycerine, 1.8g dimethyl is added
Silicone oil, 20g aucubins (purity 80%), 0.1g soluble perfumes, 0.2g sodium hydroxy methyl glycinates, with 10% hydroxide
Potassium tune pH to 6.5 stirs 15~20min, discharging.
The preparation of II agent：37.5g deionized waters are heated to 70~80 DEG C, take 16.88g deionized waters that 1.8g lemons are added
Triethylenetetraminehexaacetic acid ester, 0.9g mono stearate glyceryl esters, 1.1g Tween-80s, high speed emulsification shearing, the solid content of emulsifying liquid is about at this time
15%, if foam excessively can in right amount plus dimethicone defoaming, then 9.38g deionized waters be added into the emulsifying liquid, stir
It mixes to room temperature, which is poured into 58.7g methacrylic acids and ethyl acrylate (1:1) aqueous copolymer dispersion is (poly-
Close object content 30%) in, moderate-speed mixer, then will use in advance 11.25g deionized water dissolving 4.8g beta-glucosidases (enzyme
Rate activity is 40U/mg), the enzyme solutions prepared by 0.01g sodium sulfites pour into methacrylic acid and ethyl acrylate (1:1) altogether
Copolymer solution simultaneously stirs 20~50min (300~1000r/min, 30~45 DEG C), at this time the solid content of emulsifying liquid about 25%.
Emulsion spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, leaving air temp 50~120
℃。
It has hair dyed according to application method, I agent, II agent is uniformly mixed, 40~50 DEG C of heat preservation about 20~30min are spare, simultaneously
Often the hair scale piece of hair epidermis is opened with softening agent using hairdressing, softening agent is washed with water after 10~15min, then
The mixture of I agent, II agent is applied on hair, 40~50 DEG C of 30~60min of heat preservation, washing is clean to complete dyeing, hair
Dye black.
Claims (11)
1. permanent hairdye prepared by a kind of dyestuff and enzyme by natural botanical source, it is characterised in that it be by following I agent,
Two components of II agent are constituted, and the I agent is paste, and the II agent is pulvis：
(1) I agent includes following components by weight percentage：Aucubin 16~30%, hydroxyethyl cellulose 3~6%, glycerine
2~4%, dimethicone 1~2%, soluble perfume 0.1~0.4%, preservative 0~0.3%, balance deionized water is supplied,
With 10% potassium hydroxide tune pH to 6~10；
(2) II agent is by beta-glucosidase 1~10%, sodium sulfite 0~0.1%, methacrylic acid and ethyl acrylate copolymers
Object aqueous dispersion 50~60%, triethyl citrate 1~2%, mono stearate glyceryl ester 0.5~1%, Tween-80 0.5~
1.5%, balance deionized water is supplied, and manufactured suspension is spray-dried to be made；Wherein, the methacrylic acid and acrylic acid
Polymer content in methacrylate copolymers aqueous dispersion is 30%, the polymer be by methacrylic acid and ethyl acrylate by
According to 1:1 is polymerized.
2. a kind of production method of permanent hairdye as described in claim 1, which is characterized in that including：
(1) preparation method of I agent is：With deionized water swelling 3~6% hydroxyethyl cellulose, be added 2~4% glycerine, 1~
2% dimethicone, 16~30%, 0.1~0.4% soluble perfume of aucubin, 0~0.3% preservative, surplus go from
Sub- water is supplied, and with 10% potassium hydroxide tune pH to 6~8, stirs 15~20min, discharging；
(2) II agent preparation method is：The deionized water for accounting for total amount of deionized water 45% is heated to 70~80 DEG C, citric acid is added
Triethyl 1~2%, mono stearate glyceryl ester 0.5~1%, Tween-80 0.5~1.5%, high speed emulsification shearing emulsify at this time
The solid content 15% of liquid, adds dimethicone to defoam, then the deionized water for accounting for total Water 25% is added to the emulsifying liquid
In, it stirs to room temperature, which is poured into 50%~60% methacrylic acid and ethyl acrylate copolymer moisture
Granular media, moderate-speed mixer, then will be in advance with beta-glucosidase 1~10%, the sulfurous of the deionized water dissolving for accounting for total Water 30%
Enzyme solution prepared by sour sodium 0~0.1% pours into methacrylic acid and ethyl acrylate copolymer 20~50min of solution ＆ stir,
Speed of agitator is 300~1000r/min, and whipping temp is 30~45 DEG C, at this time the solid content 25% of emulsifying liquid, the emulsion
Spray drying obtains II agent, and the condition of spray drying is：80~180 DEG C of inlet air temperature, 50~120 DEG C of leaving air temp.
3. permanent hairdye according to claim 1, which is characterized in that aucubin, beta-glucosidase be from
It is prepared using common extracting method in plant material.
4. permanent hairdye according to claim 3, which is characterized in that aucubin purity is 60~80%.
5. permanent hairdye according to claim 4, which is characterized in that beta-glucosidase is thick enzyme, specific activity of enzyme
For 20~50U/mg.
6. permanent hairdye according to claim 5, which is characterized in that the specific activity of enzyme of beta-glucosidase be 30~
40U/mg。
7. permanent hairdye according to claim 1, which is characterized in that the matter of beta-glucosidase and aucubin
Amount is than being 1:1~1:10.
8. permanent hairdye according to claim 1, which is characterized in that the enzyme activity of beta-glucosidase and peach leaf coral
The mass ratio of coral glycosides is 2~10U：White hair can be dyed brown by 1mg.
9. permanent hairdye according to claim 1, which is characterized in that preservative is alkaline preservative methyl-isothiazol
Quinoline ketone or sodium hydroxy methyl glycinate, usage amount are respectively 0~0.01% or 0.2~0.4%.
10. permanent hairdye according to claim 1, which is characterized in that methacrylic acid and ethyl acrylate copolymers
Object aqueous dispersion is commercial prod or with methacrylic acid and ethyl acrylate copolymer, then by 30% polymer content,
10%1mol/L sodium hydroxide solutions, 60% deionized water are formulated.
11. the application method of permanent hairdye according to claim 1, which is characterized in that including：I agent, II agent is equal
Even mixing, 40~50 DEG C of 20~30min of heat preservation are spare, while using hairdressing often with softening agent by the hair scale of hair epidermis
Piece is opened, and softening agent is washed with water after 10~15min, then the mixture by I agent, II agent is applied on hair, 40~50 DEG C
30~60min is kept the temperature, washing is clean to complete dyeing.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03220115A (en) * | 1990-01-23 | 1991-09-27 | Rokuro Kiyohara | Hair dyeing cosmetic |
| CN101836945A (en) * | 2010-04-13 | 2010-09-22 | 武汉大学 | Chinese medicinal hair dye and preparation method thereof |
| CN103565686A (en) * | 2012-08-06 | 2014-02-12 | 武汉科亿华科技有限公司 | Permanent plant hair dye and preparation method thereof |
| CN104480096A (en) * | 2014-11-27 | 2015-04-01 | 陕西师范大学 | Method for cross-linking polymerization of beta-glucosaccharase |
-
2015
- 2015-04-17 CN CN201510182835.8A patent/CN105456053B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03220115A (en) * | 1990-01-23 | 1991-09-27 | Rokuro Kiyohara | Hair dyeing cosmetic |
| CN101836945A (en) * | 2010-04-13 | 2010-09-22 | 武汉大学 | Chinese medicinal hair dye and preparation method thereof |
| CN103565686A (en) * | 2012-08-06 | 2014-02-12 | 武汉科亿华科技有限公司 | Permanent plant hair dye and preparation method thereof |
| CN104480096A (en) * | 2014-11-27 | 2015-04-01 | 陕西师范大学 | Method for cross-linking polymerization of beta-glucosaccharase |
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