CN106726757B - Peony seed oil microemulsion gel and preparation method thereof - Google Patents
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Abstract
The invention discloses a peony seed oil microemulsion gel which is prepared from the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water. The preparation method comprises the following steps: mixing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone, adding into a mixture of glycerol, trehalose, sodium hyaluronate and deionized water, performing ultrasonic post-homogenization treatment, and continuously stirring to obtain the final product. The preparation method combines ultrasonic emulsification and high-pressure homogeneous emulsification, and the prepared microemulsion gel has finer particles, fine hand feeling and easy coating and permeation into skin for absorption.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a peony seed oil microemulsion gel agent and a preparation method thereof.
Background
The peony seed is a seed of deciduous shrub peony of Paeonia of Ranunculaceae, the peony seed oil is a golden yellow transparent oil substance extracted from the peony seed, the content of unsaturated fatty acid of the peony seed oil reaches more than 90%, wherein the content of α -linolenic acid (omega-3 series) exceeds 40%, which is 120 times of olive oil, modern research shows that the peony seed oil has higher nutrition and health care functions, such as blood fat reduction, antioxidation, liver protection, blood sugar reduction, body immunity improvement, radiation resistance, sun protection and the like, the strong antioxidation, radiation resistance and whitening effects of the peony seed oil can effectively prevent skin wrinkles and lipofuscin substance accumulation, promote skin tissue regeneration and epithelial tissue healing, so the peony seed oil gradually becomes a research hotspot in the field of cosmetics, the application No. 201510976466, the patent of Chinese patent application No. 2015.12.21, the publication No. CN105411882A, the publication No. 2016.3.23 discloses a cosmetic composition which adopts paeonol, peony essential oil and peony seed oil, can obviously improve the skin epidermal cell circulation function, promote the microcirculation of skin vessels, delay the skin aging, and is easily caused by the addition of an antioxidant, anti-whitening and whitening emulsion, which is easily caused by the addition of a common peony seed oil, the peony seed extract of peony seed oil, the peony seed extract of the cosmetic has the cosmetic of the cosmetic, the cosmetic of peony seed extract of the peony seed extract of peony seed extract, the peony seed extract of peony seed extract, the.
The microemulsion is an emulsion with the particle size of less than 100nm, the microemulsion cosmetic has the advantages of high stability, small particle size, easiness in absorption by skin, fine hand feeling and the like, the microemulsion is lack of adhesiveness, the residence time on the skin is short, the microemulsion cosmetic is further prepared into gel, the action time of the microemulsion cosmetic is favorably prolonged, and the gel is fresh and cool in touch, moist, easy to coat and widely popular with consumers. At present, the application of the peony seed oil in the field of cosmetics through microemulsifying and preparing the gel is not reported.
Disclosure of Invention
The invention aims to provide a peony seed oil microemulsion gel, which combines microemulsion and gel, has no greasy feeling, can be quickly absorbed, has high stability, and uses a safe and nontoxic substrate.
The invention also aims to provide a preparation method of the peony seed oil microemulsion gel.
The technical scheme adopted by the invention is that the peony seed oil microemulsion gel comprises the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water.
The invention adopts another technical scheme that a preparation method of the peony seed oil microemulsion gel agent is implemented according to the following steps:
step 1, weighing the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water;
step 3, mixing glycerol, trehalose, sodium hyaluronate and deionized water, and stirring at 70-75 ℃ until the mixture is completely dissolved, and marking as a material II;
step 4, slowly adding the material I into the island material II, uniformly stirring while adding, and performing ultrasonic treatment to form a uniform emulsion;
and 5, homogenizing the emulsion obtained in the step 4, stirring, and cooling to room temperature to obtain the peony seed oil microemulsion gel.
The present invention is also characterized in that,
the power of ultrasonic treatment in the step 4 is 10-20W, and the time is 1-5 min.
In the step 5, the homogenization treatment is to homogenize the emulsion for 5-20min under 500-1000bar by a high-pressure homogenizer.
And the stirring time in the step 5 is 15-20 min.
The invention has the beneficial effects that firstly, the microemulsion belongs to a thermodynamic stability system, and because the emulsion has smaller particle size and is uniformly dispersed in a gel matrix, and liquid drops are more difficult to combine into macromolecules to be separated out, the microemulsion cosmetic has better stability compared with common cosmetics; secondly, due to the solubilization of the microemulsion, the content of the peony seed oil in a product system can be increased, and the defects of high oil content and instability of common cosmetics are overcome; in addition, the preparation method combines ultrasonic emulsification and high-pressure homogeneous emulsification, and the prepared microemulsion gel has finer particles and fine hand feeling, and is easy to coat and permeate into the skin to be absorbed. The microemulsion gel provided by the invention can be widely applied to the field of cosmetics such as skin care products, shampoos, facial masks and the like.
Drawings
FIG. 1 is a particle size distribution diagram of the peony seed oil microemulsion prepared in examples 1-3;
FIG. 2 is a shape chart of the peony seed oil microemulsion gelling agent prepared in examples 1-3;
FIG. 3 shows the results of the water loss rate test of the peony seed oil microemulsion gel prepared in examples 1-3.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
The peony seed oil microemulsion gel disclosed by the invention comprises the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water.
The preparation method of the peony seed oil microemulsion gel is specifically implemented according to the following steps:
step 1, weighing the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water;
step 3, mixing glycerol, trehalose, sodium hyaluronate and deionized water, and stirring at 70-75 ℃ until the mixture is completely dissolved, and marking as a material II;
step 4, slowly adding the material I into the island material II, uniformly stirring while adding, and performing ultrasonic treatment for 1-5min at 10-20W to form a uniform emulsion;
and 5, homogenizing the emulsion obtained in the step 4 for 5-20min at 500-1000bar by a high-pressure homogenizer, then continuously stirring for 15-20min, and then cooling to room temperature to obtain the peony seed oil microemulsion gel.
Example 1
The peony seed oil microemulsion gel consists of the following components in parts by weight:
the preparation method comprises the following steps:
(1) weighing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone in sequence, adding the raw materials into a clean beaker in sequence, heating to 80 ℃, stirring for 30 minutes until the raw materials are completely dissolved, and marking as a material I;
(2) taking a dry clean beaker, weighing glycerol, trehalose, sodium hyaluronate and deionized water in sequence, adding the raw materials in sequence, stirring at 75 ℃ until the raw materials are completely dissolved, and marking as a material II;
(3) slowly adding the material I into the material II while stirring, and performing ultrasonic treatment at 15W for 2 minutes until a uniform emulsion is formed;
(4) homogenizing the emulsion with a high pressure homogenizer at 1000bar for 15 minutes;
(5) and (5) continuing stirring the materials in the step (4) for 15 minutes, cooling to normal temperature, and discharging to obtain a finished product.
Example 2
The peony seed oil microemulsion gel consists of the following components in parts by weight:
the preparation method comprises the following steps:
(1) weighing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone in sequence, adding the raw materials into a clean beaker in sequence, heating to 75 ℃, stirring for 30 minutes until the raw materials are completely dissolved, and marking as a material I;
(2) taking a dry clean beaker, weighing glycerol, trehalose, sodium hyaluronate and deionized water in sequence, adding the raw materials in sequence, stirring at 70 ℃ until the raw materials are completely dissolved, and marking as a material II;
(3) slowly adding the material I into the material II while stirring, and performing ultrasonic treatment at 10W for 3 minutes until a uniform emulsion is formed;
(4) homogenizing the emulsion with a high pressure homogenizer at 800bar for 20 minutes;
(5) and (5) continuing stirring the materials in the step (4) for 15 minutes, cooling to normal temperature, and discharging to obtain a finished product.
Example 3
The peony seed oil microemulsion gel consists of the following components in parts by weight:
the preparation method comprises the following steps:
(1) weighing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone in sequence, adding the raw materials into a clean beaker in sequence, heating to 80 ℃, stirring for 30 minutes until the raw materials are completely dissolved, and marking as a material I;
(2) taking a dry clean beaker, weighing glycerol, trehalose, sodium hyaluronate and deionized water in sequence, adding the raw materials in sequence, stirring at 75 ℃ until the raw materials are completely dissolved, and marking as a material II;
(3) slowly adding the material I into the material II while stirring, and performing ultrasonic treatment at 15W for 1 minute until a uniform emulsion is formed;
(4) homogenizing the emulsion with a high pressure homogenizer at 600bar for 20 minutes;
(5) and (5) continuing stirring the materials in the step (4) for 15 minutes, cooling to normal temperature, and discharging to obtain a finished product.
Example 4
The peony seed oil microemulsion gel consists of the following components in parts by weight:
the preparation method comprises the following steps:
(1) weighing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone in sequence, adding the raw materials into a clean beaker in sequence, heating to 70 ℃, stirring for 20 minutes until the raw materials are completely dissolved, and marking as a material I;
(2) taking a dry clean beaker, weighing glycerol, trehalose, sodium hyaluronate and deionized water in sequence, adding the raw materials in sequence, stirring at 72 ℃ until the raw materials are completely dissolved, and marking as a material II;
(3) slowly adding the material I into the material II while stirring, and performing ultrasonic treatment at 20W for 4 minutes until a uniform emulsion is formed;
(4) homogenizing the emulsion with a high pressure homogenizer at 500bar for 5 minutes;
(5) and (5) continuing stirring the materials in the step (4) for 20 minutes, cooling to normal temperature, and discharging to obtain a finished product.
Example 5
The peony seed oil microemulsion gel consists of the following components in parts by weight:
the preparation method comprises the following steps:
(1) weighing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone in sequence, adding the raw materials into a clean beaker in sequence, heating to 75 ℃, stirring for 40 minutes until the raw materials are completely dissolved, and marking as a material I;
(2) taking a dry clean beaker, weighing glycerol, trehalose, sodium hyaluronate and deionized water in sequence, adding the raw materials in sequence, stirring at 70 ℃ until the raw materials are completely dissolved, and marking as a material II;
(3) slowly adding the material I into the material II while stirring, and performing ultrasonic treatment at 18W for 5 minutes until a uniform emulsion is formed;
(4) homogenizing the emulsion with a high pressure homogenizer at 900bar for 10 minutes;
(5) and (5) continuing stirring the materials in the step (4) for 18 minutes, cooling to normal temperature, and discharging to obtain a finished product.
The peony seed oil microemulsion gel agent is tested through related test experiments to illustrate the performance of the peony seed oil microemulsion gel agent.
First, the peony seed oil microemulsion gel prepared in examples 1 to 3 is measured for particle size, the distribution diagram is shown in fig. 1, and the microemulsion form is observed under an inverted microscope, which is shown in fig. 2. As can be seen from the figures 1 and 2, the average particle size of the peony seed oil microemulsion is about 38.02nm, and the peony seed oil microemulsion is in a spherical shape with uniform size.
Physical stability test of (II) peony seed oil microemulsion gel
The proper amount of the peony seed oil microemulsion gelling agent is taken and centrifuged for 20 minutes at the rotating speed of 5000r/min, the proper amount of the peony seed oil microemulsion gelling agent is taken and respectively stored for 10 days at the temperature of 10 ℃, 25 ℃, 40 ℃ and 60 ℃ without oil-water stratification during the storage period, and the particle size distribution of emulsion drops has no obvious change.
(III) moisture retention test
At 25 deg.C and 40% humidity, 4 microporous filter membranes of 0.22 μm are placed on a piece of water-impermeable silica paper, 5 drops of purified water are respectively dropped on the filter membranes, and the filter membranes are immediately weighed. The peony seed oil microemulsion gelling agents of examples 1 to 3 were then uniformly coated on the No. 1 to 3 filter membranes, respectively, and immediately weighed, and the No. 4 membrane was not coated, as a control group. The water loss was then measured for filters No. 1-4 at 5, 15, 30, 60, 120 minutes, respectively. The water loss rate calculation formula is as follows:
wherein M isnFor the weight of the sample after standing, MoIs the sample weight before placement.
The results are shown in fig. 3, and it can be seen from the results in fig. 3 that the water loss rate of the filter membranes in the groups of examples 1 to 3 is obviously lower than that of the control group, which indicates that the peony seed oil microemulsion gel prepared by the invention has a good moisturizing effect, can effectively improve the skin elasticity, and promotes the skin hydration so as to further increase the transdermal penetration of oil.
(IV) coating property test of peony seed oil microemulsion gelling agent
The proper amount of the peony seed oil microemulsion gelling agent and the proper amount of the peony seed oil in the embodiments 1 to 3 are respectively taken and coated on the double-silicon paper (with hydrophobicity similar to that of the skin) for observation, so that the fact that the coating process of the peony seed oil microemulsion gelling agent is easy and has no oil drop aggregation phenomenon is found, and after the peony seed oil is coated, oil drop aggregation appears on the surface of the double-silicon paper quickly and is not easy to coat uniformly, which indicates that the peony seed oil prepared into the microemulsion gelling agent is beneficial to coating on the skin, is more beneficial to full contact with the skin to promote absorption, and reduces greasy feeling. The microemulsion gel prepared by the raw material formula prepared in the examples 1-3 according to a conventional method is used as a sample for experiments, and is tried by 30 female volunteers aged 18-45 years, so that the microemulsion gel has refreshing feeling, is easy to coat and has no greasy feeling.
Claims (2)
1. A preparation method of a peony seed oil microemulsion gel is characterized by comprising the following steps:
step 1, weighing the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water;
step 2, mixing peony seed oil, polyoxyethylene fatty alcohol ether, polyoxyethylene hydrogenated lanolin, squalane and silicone, heating to 70-80 ℃, stirring for 20-40min until the components are completely dissolved, and marking as a material I;
step 3, mixing glycerol, trehalose, sodium hyaluronate and deionized water, and stirring at 70-75 ℃ until the mixture is completely dissolved, and marking as a material II;
step 4, slowly adding the material I into the material II, uniformly stirring while adding, and performing ultrasonic treatment to form a uniform emulsion; the power of ultrasonic treatment is 10-20W, and the time is 1-5 min;
step 5, homogenizing the emulsion obtained in the step 4 and then stirring, wherein the homogenizing treatment is to homogenize the emulsion for 5-20min under 500-1000bar by a high-pressure homogenizer and then cool the emulsion to room temperature to obtain the peony seed oil microemulsion gel;
the peony seed oil microemulsion gel consists of the following components in parts by weight: 1-5 parts of polyoxyethylene fatty alcohol ether, 0.5-3 parts of polyoxyethylene hydrogenated lanolin, 3-10 parts of squalane, 1-10 parts of peony seed oil, 0.5-3 parts of silicone, 1-5 parts of glycerol, 4-6 parts of trehalose, 0.01-2.0 parts of sodium hyaluronate and 10-20 parts of deionized water.
2. The preparation method of the peony seed oil microemulsion gel agent as claimed in claim 1, wherein the stirring time in the step 5 is 15-20 min.
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| CN108685992B (en) * | 2018-07-31 | 2021-03-02 | 上品（洛阳）牡丹产业有限公司 | Peony seed oil stock solution with cell repairing function and preparation method thereof |
| CN113116755A (en) * | 2021-05-27 | 2021-07-16 | 山东花物堂生物科技有限公司 | Skin care composition for promoting penetration and preparation method and application thereof |
| CN114533647B (en) * | 2022-03-31 | 2023-06-16 | 广州旭妆生物科技有限公司 | Silicone oil-free anti-dandruff shampoo composition and preparation method thereof |
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| CN104188826A (en) * | 2013-10-18 | 2014-12-10 | 王满欣 | Peony seed oil microemulsion and preparation method and application thereof |
| CN104920642A (en) * | 2015-07-03 | 2015-09-23 | 山东省分析测试中心 | Food-grade peony seed blend oil microemulsion and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188826A (en) * | 2013-10-18 | 2014-12-10 | 王满欣 | Peony seed oil microemulsion and preparation method and application thereof |
| CN104920642A (en) * | 2015-07-03 | 2015-09-23 | 山东省分析测试中心 | Food-grade peony seed blend oil microemulsion and preparing method thereof |
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| Title |
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| 微乳凝胶经皮给药制剂的研究与应用进展;谢明华等;《中国现代应用药学》;20150623;第32卷(第6期);第764-768页 * |
| 茶树油微乳凝胶的制备及其质量评价;卢秀霞等;《中草药》;20150712;第46卷(第13期);第1892-1900页 * |
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