CN108685992B - Peony seed oil stock solution with cell repairing function and preparation method thereof - Google Patents
Peony seed oil stock solution with cell repairing function and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention relates to the technical field of health care products, in particular to a peony seed oil stock solution with a cell repairing function and a preparation method thereof, wherein the peony seed oil stock solution comprises the following components: peony seed oil glycoside, cortex moutan polyphenol, squalene, vitamin a/e/f, fucosterol and peony essential oil; the peony seed oil stock solution with the cell repair function wraps various active ingredients, and the peony seed oil contains a large amount of cell growth factors, so that the peony seed oil has the repair function on epithelial cells, endothelial cells, hematopoietic cells and the like in skin organs, has a good repair effect on skin, promotes the cell repair skin function, recovers the skin activity, reduces the skin surface where harmful substances are retained, and can quickly relieve severe pruritus and allergic symptoms; the preparation method of the peony seed oil stock solution can maintain the activity of cells for a long time while repairing the cells, slow down the aging of cell growth factors, enable the repair solution to be stored for a long time and better exert the curative effect.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to a peony seed oil stock solution with a cell repairing function and a preparation method thereof.
Background
The polyenoic acid vegetable oil is natural vegetable oil which is mainly composed of polyenoic acid extracted from plant fruits, seeds and germs, and is rich in various active substances such as VE, plant c < alcohol, trace elements and the like. The polyene acid vegetable oil contains oleic acid, palmitic acid, etc
Mainly contains polyunsaturated fatty acids such as linoleic acid and linolenic acid with two or more double bonds, such as grape seed oil, perilla oil, linseed oil, caragana fruit, seed oil, etc.
Linolenic acid and linoleic acid are essential fatty acids for human body, are closely related to life activities, can regulate lipid metabolism of human body, has the effect of assisting in reducing blood fat, can treat and prevent cardiovascular and cerebrovascular diseases, and has important physiological effects in the aspects of resisting cancer, resisting oxidation, delaying aging, regulating immunity, losing weight, protecting skin, beautifying and the like [ I21 ]. Therefore, the polyenoic acid vegetable oil can be used as edible oil to meet the requirement of human body fat
The intake requirement of fatty acid can be used for producing medicines and health-care foods, and can also be used as an oily raw material of cosmetics, so that the development and utilization prospect is wide.
The peony is widely distributed in various parts of China, according to statistics, the planting area reaches 30 ten thousand mu, in recent years, people gradually develop the application value of each component of the peony, many experts and scholars are interested in researching the peony bark in recent years, the research on peony seeds is less, if the peony seeds contain various active ingredients, the prepared peony seed oil also has high nutritional value and medical value, and the research and development of the peony seed oil and the peony seed protein have important significance for the edible oil industry and the plant protein industry in China.
At present, the research and utilization of plant protein in China are mostly limited to soybean meal, cottonseed meal and other common plant meals, the research on the extraction of peony seed meal protein is very little, and the literature report about peony seed protein is also very rare. The peony seed protein is a plant protein with rich amino acid composition, the development of the peony seed protein can relieve the current situation of shortage of plant protein in China, and the resource of the plant protein in China is enriched.
People have first recognized peony from medicinal value. In 1972, the prescription of peony for treating the blood-nodule disease in early tomb-expanding medical simplicity discovered in the arborvitae countryside of Wuwei city, Gansu province is the earliest written record of peony in the existing data. The great planting of paeonia ostii on the copper tomb of Anhui mainly aims at obtaining the cortex moutan (the traditional Chinese medicine cortex moutan is a traditional famous and precious traditional Chinese medicine material in China, the main component of the cortex moutan is paeonol which has the effects of clearing heat and cooling blood, activating blood and dissipating stasis, and diminishing inflammation and leading back to channels) The flavone and polyphenol compounds such as gallic acid have the effects of regulating menstruation and activating blood, and the peony extract has an obvious effect of removing free radicals and can protect DNA oxidative damage caused by OH.
Disclosure of Invention
Therefore, the invention provides a peony seed oil stock solution with a cell repair function and a preparation method thereof, aims to overcome the defects of the prior art, provides a skin repair solution capable of effectively improving the skin repair effect, has comprehensive functions, can improve and repair skin cells, and enables cell tissues lacking nourishment to fully absorb nutrition and moisture, thereby increasing the anti-inflammation capability of the skin cells. The skin care product has the advantages of repairing skin cell activity, improving skin cell immunity, resisting inflammation and bacteria, relieving pain and calming, clearing away heat and toxic materials, and relieving swelling and pain, and has unique curative effects on skin eczema, severe pruritus and tinea.
The technical scheme of the invention is realized as follows: a peony seed oil stock solution with cell repairing function comprises the following components: 25-35% of peony seed oil glycoside, 22-30% of cortex moutan polyphenol, 25-30% of squalene, 25-2% of vitamin a1, 3-1% of vitamin e, 1-3% of vitamin f, 8-15% of fucosterol and 1-2% of peony essential oil.
Further, 28-32% of peony seed oil glycoside, 22-28% of cortex moutan polyphenol, 26-30% of squalene, 1-2% of vitamin a, 1-2% of vitamin e, 1-2% of vitamin f, 8-12% of fucosterol and 1-2% of peony essential oil.
Further, 30% of peony seed oil glycoside, 25% of cortex moutan polyphenol, 28% of squalene, 1% of vitamin a, 2% of vitamin e, 2% of vitamin f, 10% of fucosterol and 2% of peony essential oil.
Further, the extraction method of the peony seed oil glycoside comprises the following steps: putting 800mL of prepared peony seed oil raw juice into a rotary evaporator, and evaporating at a low temperature, wherein the temperature is controlled at 50 ℃; controlling the temperature by adjusting the vacuum degree; dissolving peony seed oil in 200mL of ethanol, and recrystallizing and purifying; finally, carrying out reduced pressure filtration, filtering out the peony seed oil, and drying by using an infrared lamp; thus, the extraction of the peony seed oil glucoside is finished.
Further, the cortex moutan polyphenol is extracted to the root of peony, and the extraction method is an ethanol percolation method: soaking peony root in 75% ethanol for 10-15 hr at percolation rate of 6 ml/min.
A preparation method of peony seed oil stock solution with cell repairing function comprises weighing various raw materials according to a formula, adding propylene glycol into a beaker filled with peony seed oil stock solution, stirring to dissolve, filtering to remove impurities to clarify the solution, adding the weighed peony seed oil glycoside into the beaker, and strongly stirring with an electric stirrer.
Through the disclosure, the beneficial effects of the invention are as follows: the peony seed oil stock solution with the cell repair function wraps various active ingredients, and is mixed and added with peony seed oil according to a predetermined weight ratio to obtain an extracting solution with the cell repair function, and the peony seed oil contains a large amount of cell growth factors, has the repair function on epithelial cells, endothelial cells, hematopoietic cells and the like in skin organs, is rich in zinc, iron and the like, has a good repair function on skin by matching with the active ingredients, promotes the cell repair skin function, recovers the skin activity, reduces the skin surface where harmful substances are retained, and can quickly relieve severe itching and allergic symptoms; according to the preparation method of the peony seed oil stock solution with the cell repairing function, provided by the invention, the activity of the peony seed oil stock solution can be kept for a long time while the cells are repaired, so that the aging of cell growth factors is slowed down, the repairing solution can be stored for a long time, and the curative effect is better exerted; has anti-inflammatory and anti-proliferative effects, has effects in relieving erythema and inflammation reaction caused by ultraviolet, improving skin permeability, promoting penetration and absorption of bioactive substances, and has anti-inflammatory effect in cooperation with anti-inflammatory agent; has obvious improvement and treatment effects on various skin inflammations such as skin allergy, eczema, baby diaper rash, skin burn and the like.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a peony seed oil stock solution with a cell repairing function and a preparation method thereof.
Example 1
A peony seed oil stock solution with cell repairing function comprises the following components: 25% of peony seed oil glycoside, 30% of cortex moutan polyphenol, 28% of squalene, 2% of vitamin a, 1% of vitamin e, 3% of vitamin f, 9% of fucosterol and 2% of peony essential oil.
Example 2
A peony seed oil stock solution with cell repairing function comprises the following components: 30% of peony seed oil glycoside, 25% of cortex moutan polyphenol, 28% of squalene, 1% of vitamin a, 2% of vitamin e, 2% of vitamin f, 10% of fucosterol and 2% of peony essential oil.
Example 3
A peony seed oil stock solution with cell repairing function comprises the following components: 33% of peony seed oil glycoside, 22% of cortex moutan polyphenol, 25% of squalene, 1% of vitamin a, 2% of vitamin e, 3% of vitamin f, 8% of fucosterol and 2% of peony essential oil.
Example 4
In the above example 1 or 2 or 3, the method for extracting peony seed oil glycoside;
putting 800mL of prepared peony seed oil raw juice into a rotary evaporator, and evaporating at a low temperature controlled at 50 ℃. The temperature was controlled by adjusting the vacuum.
200mL of ethanol is taken to dissolve the peony seed oil, and recrystallization purification is carried out. And finally, carrying out reduced pressure filtration, filtering out the peony seed oil, and drying by using an infrared lamp. Thus, the extraction of the peony seed oil glucoside is finished.
Preparation method of peony seed oil stock solution with cell repairing function
Weighing various raw materials according to a formula, adding propylene glycol into a beaker filled with the peony seed oil raw juice, stirring to dissolve the propylene glycol, filtering out impurities to clarify the solution, then adding the weighed peony seed oil glucoside into the beaker, and strongly stirring by using an electric stirrer.
Measuring moisture retention, respectively weighing lOg prepared stock solution and placing in P40X 25; weighing the bottle without covering, putting the bottle into an oven at 30 ℃, taking out the bottle every 4 hours, and weighing the bottle. The water loss rate was calculated according to the following formula. The results are shown in Table 1:
TABLE 1
SI% (W1-W χ)/(W1-2) × 100% formula: SI is the water loss rate; w1 is the weight (g) of the stock solution before the experiment; w chi is the stock solution and the weight (g) of the weighing bottle after a specified time interval; w is the weight of the weighing bottle (g).
Results and discussion
The moisture retention is measured, and the smaller the water loss rate is, the better the moisture retention is;
the stratum corneum of the skin contains a hydrophilic hygroscopic substance called a natural thermal insulation factor CN MF), which plays an important role in moisturizing the skin. Amino acid, organic acid, trace metal and the like contained in the peony seed juice are all components contained in NMF, and the peony seed juice can be used as a bionic advanced humectant simulating NMF which is a natural protection mechanism. As can be seen from Table 1, when the content of the raw juice of peony seed oil is 50%, the water loss rate is the smallest and the moisture retention is the best. The moisture retention is superior to that of glycerin containing 10%.
The peony seed extract contains unsaturated fatty acids such as oleic acid, linoleic acid, linolenic acid and the like, and has important effects on oxidation resistance and free radical removal. The skin aging is closely related to free radicals, and the peony seed oil can prevent peroxidation caused by the free radicals to a certain extent, so that the aging is prevented and pigment spots are lightened; alpha-linolenic acid can promote skin absorption, thereby increasing skin elasticity and luster, and can be widely applied to cosmetics such as bath cream, sunscreen cream, facial mask and the like to play the roles of scavenging free radicals, resisting inflammation and infection, resisting radiation, enhancing immunity and the like.
The peony flower extract contains essential fatty acids, proteins, amino acids, saccharides, vitamin C VC, VB1, VB2, carotenoid, mineral elements, trace elements (Cu, Fe, Zn, Mn, Co, Ni) and the like. It has the unique effects of improving the immunity of organisms, preventing arteriosclerosis, dredging the channels, activating blood circulation, nourishing and activating skin and the like.
The active components of the peony leaf extract comprise acid, phenol, sugar, protein, flavone and the like. The content of total flavonoids in peony leaves is 1.47-1.57%, and the extract of peony leaves has antioxidant effect on lard and sesame oil, and has slightly less influence on lard than sesame oil.
The moutan root extract is mushroom and its analogs, phenol and its analogs, alkaloid, volatile oil, phytosterol, organic acid, etc., wherein the content of phenol and its analogs is relatively slightly higher. The main active ingredients of cortex moutan include Paeonia lactiflora, cortex moutan polysaccharide, paeonol, etc. Radix Paeoniae is effective in resisting myocardial ischemia, hematogenesis, tumor, allergy and inflammation; the cortex moutan polysaccharide has effects of reducing blood sugar, and preventing and improving diabetes and its complications. Paeonol has antithrombotic, antiatherosclerotic, antioxidant, and antiviral effects.
The efficacy of the invention was tested as follows:
testing for severe pruritus:
the test subjects were 5 volunteers (3 women, 2 men) aged between 30 and 65 years, with severe itching symptoms in the extremities.
After the product is used twice a day (morning and evening), the product is sprayed on the pruritus area, and after the product is continuously used for 5-7 days, the pruritus is obviously relieved, pink scabs are formed at the damaged part of the skin, and the skin is recovered to be normal. After 10 days of use, the itching did not recur.
The repair liquid is used for improving the skin elasticity; the skin elasticity is increased by 50% on average after the product is sprayed on the facial skin for 10 days.
Testing of facial skin allergy:
the test subjects were 5 volunteers (4 women, 1 male) aged between 30 and 45 years, with frequent manifestations of facial allergies.
The product is sprayed on an allergic swelling area after allergy, the swelling of allergic skin begins after 30 minutes to 2 hours, after the product is applied for 3 to 4 times in one day, the allergic symptoms disappear, the interval of the allergy again is prolonged, and the allergy rarely recurs after three times of application.
Finally, the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all of them should be covered in the claims of the present invention.
Claims (1)
1. A peony seed oil stock solution for treating skin allergy is characterized in that: the composition consists of the following components:
30% of peony seed oil glycoside, 25% of cortex moutan polyphenol, 28% of squalene, 1% of vitamin a, 2% of vitamin e, 2% of vitamin f, 10% of fucosterol and 2% of peony essential oil;
the extraction method of the peony seed oil glycoside comprises the following steps: putting 800mL of prepared peony seed oil raw juice into a rotary evaporator, and evaporating at a low temperature, wherein the temperature is controlled at 50 ℃; controlling the temperature by adjusting the vacuum degree; dissolving peony seed oil in 200mL of ethanol, and recrystallizing and purifying; finally, carrying out reduced pressure filtration, filtering out the peony seed oil, and drying by using an infrared lamp; so far, the extraction of the peony seed oil glucoside is finished;
the cortex moutan polyphenol is extracted from peony root, and the extraction method is ethanol percolation: soaking peony root in 75% ethanol for 10-15 hr at percolation rate of 6 ml/min.
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| CN107586593A (en) * | 2017-09-21 | 2018-01-16 | 甘肃农业大学 | A kind of method that peony seeds essential oil is extracted from peony seeds |
| CN108309828A (en) * | 2018-03-19 | 2018-07-24 | 恒天量子（厦门）科技有限公司 | One kind heal-care essential oil containing peony seed oil and preparation method thereof, cosmetics |
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