CN107216942A - A kind of production method of the cosmetic oil based on peony seeds - Google Patents

A kind of production method of the cosmetic oil based on peony seeds Download PDF

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Publication number
CN107216942A
CN107216942A CN201710250986.1A CN201710250986A CN107216942A CN 107216942 A CN107216942 A CN 107216942A CN 201710250986 A CN201710250986 A CN 201710250986A CN 107216942 A CN107216942 A CN 107216942A
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ethyl acetate
extraction
ethanol
peony
peony seeds
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CN201710250986.1A
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Chinese (zh)
Inventor
彭红
张锦胜
郑洪立
巫小丹
王允圃
刘玉环
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Nanchang University
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Nanchang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/02—Pretreatment
    • C11B1/04—Pretreatment of vegetable raw material
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

A kind of production method of the cosmetic oil based on peony seeds, belongs to cosmetics processing technique field.The present invention by peony seeds by drying, be crushed to certain particle size；Add after ethanol and the pretreatment of ethyl acetate microwave radiation technology, supercritical CO is carried out using ethanol and ethyl acetate as entrainer2Extraction, pressure is extraction under the conditions of 20~30MPa, 45~50 DEG C of temperature；Then separated in knockout drum at pressure 3MPa~6MPa, 25~30 DEG C of temperature.After reclaiming ethanol and ethyl acetate through vacuum distillation, extraction oil obtains anti-oxidant peony seed oil by adding carnosine, Tea Polyphenols and lycopene composite antioxidant after solubilising.Extraction rate of the present invention is fast, recovery rate is high, no solvent residue, and the high quality oils water activity of acquisition is low, with anti-oxidant and vegetative cell function, and water retention property and Storage are all good, can be used as in cosmetics of super quality base starting material.

Description

A kind of production method of the cosmetic oil based on peony seeds
Technical field
The invention belongs to cosmetics processing technique field, it is related to the production method of cosmetic oil.
Background technology
General principle：Peony seeds about oil-containing 25-30%, peony seed oil also has abundant leukotrienes, linoleic acid, oleic acid, peanut Olefin(e) acid, palmitic acid and stearic acid etc., meanwhile, also containing oleanolic acid, hederagenin, Kaempferol, cyanidenon, Ke Yili Element, apiolin, trans Portugal's root element, trans-resveratrol, cis Portugal's root element, stigmasterol, cupreol and β-daucosterol etc. Multiple biological activities composition, for cosmetics can make soft lubrication, skin nutrition cell effect.Lycopene can promote cell Growth and regeneration, beauty Eradicates wrinkles maintain skin health, the effects such as anti-aging, can substantially improve skin allergy, eliminate because Dry skin caused by allergic and scratchiness, make us feeling relaxed happy.Carnosine can be removed during oxidative stress Make active oxygen radical formed by the aliphatic acid over oxidation of cell membrane（ROS）And alpha-beta unsaturated aldehyde.Skin can be prevented Aging and the effect brightened of skin, carnosine can prevent free radical from producing, repair skin injury, the function with vegetative cell.
The principle of microwave treatment is to penetrate spe medium using frequency electromagnetic waves, reaches the inside for being extracted material, microwave Heat energy can be quickly converted to and make the temperature rapid increase of cell interior.When the pressure of cell interior exceedes the ability to bear of cell When, cell will rupture, and active ingredient is i.e. from intracellular outflow, and be dissolved in spe medium at a lower temperature.
Supercritical CO2The principle of fluid extraction separation is the relation of the solvability using supercritical fluid and its density, Influence i.e. using pressure and temperature to supercritical fluid solvability and extract.In the supercritical state, will be overcritical Fluid is contacted with material to be separated, make its selectively polarity size, boiling point height it is different with molecular size range into Divide and extract successively.Certainly, the extract obtained by each pressure limit of correspondence is unlikely to be single, but can be with control condition The blending constituent of optimal proportion is obtained, then supercritical fluid is become common gases by the method for decompression, heating, is extracted Material is then wholly or substantially separated out, so that the purpose of separating-purifying is reached, so supercritical CO2Fluid extraction process is by extracting Combined with separation process.Supercritical CO2The sharpest edges of fluid extraction are no solvent residues, and natural active matter is obtained It is effectively maintained.In the present invention, ethanol and ethyl acetate are in supercritical CO2Play entrainer during fluid extraction, Extraction efficiency can be improved.And different from general organic solvent, provide that ethanol and ethyl acetate are fair according to GB 2760-96 Perhaps the flavorant used, for cosmetics more without toxic side effect.Extraction under the conditions of 45-60 DEG C, high vacuum carry out The recyclable ethanol of vacuum distillation and ethyl acetate obtain product.The grease extracted at the process conditions has the same of bioactivity When, its antioxidation activity is low, easy oxidation deterioration.Carnosine, Tea Polyphenols and tomato red have extraordinary antioxygenic property, three Also there is synergy in the presence of simultaneously, antioxidation activity is greatly improved.But carnosine and Tea Polyphenols do not dissolve in grease, kind Lycopene is water insoluble, it is impossible to which three is directly added into grease, finds carnosine and Tea Polyphenols being dissolved in after water by studying, plus The binary compound emulsifying agent for entering HLB value 5-6 monoglyceride and HLB value 12-15 nonionic polyoxyethylene monolaurate can To promote lycopene to dissolve, add in grease and form the particulate of Water-In-Oil and dispersed, effect very well, then uses ultrasonic wave Concussion is uniformly mixed so as to obtain the peony seed oil with antioxidation activity high bioactivity, and it contains abundant nutriment, can be used as The matrix of cosmetic.
The content of the invention
It is an object of the invention to provide a kind of production method of the cosmetic oil based on peony seeds, for producing cosmetics Matrix oil.Supercritical CO after being pre-processed by microwave radiation technology2Fluid extraction peony seed oil, addition carnosine, Tea Polyphenols and kind Lycopene improves antioxidation activity, obtains the active peony seed oil of antioxidation biology of functionalization.
This method by peony seeds by drying, being crushed to after certain particle size；Add ethanol and ethyl acetate microwave radiation technology is pre- Processing, uses supercritical CO under certain process conditions afterwards2Second is reclaimed in fluid extraction vegetable oil and active ingredient, vacuum distillation After alcohol and ethyl acetate, then using raising antioxidation activities such as certain method addition Tea Polyphenols, obtain high with antioxidation activity The peony seed oil of bioactivity.The major advantage of this method is supercritical CO at the process conditions2It is male obtained by fluid extraction Red seed oil, bioactive substance content is high, loses small.Adding has well anti-oxidant after carnosine, Tea Polyphenols and lycopene Characteristic, the grease produced with this method can make the matrix oil of cosmetics, contain a large amount of bioactivity and nutriment.
The present invention is achieved by the following technical solutions.
A kind of production method of cosmetic oil based on peony seeds of the present invention, as follows.
1）By peony seeds by drying, be crushed to certain particle size.
2）Ethanol and the pretreatment of ethyl acetate microwave radiation technology.
3）Using ethanol and ethyl acetate as entrainer supercritical carbon dioxide extraction.
4）Ethanol and ethyl acetate are reclaimed in vacuum distillation.
5）Add carnosine, Tea Polyphenols and lycopene and improve anti-oxidation characteristics.
The microwave radiation technology pretreatment, refers to and is handled 5-10 minutes in 2450MHz with Microwave Extraction reaction system.
The supercritical CO2Fluid extraction, refers in extractor under the conditions of pressure is 20~30MPa, 45~50 DEG C of temperature Extraction；Separated in knockout drum at pressure 3MPa~5MPa, 25~30 DEG C of temperature.
The raising inoxidizability.Refer to and carnosine and Tea Polyphenols are dissolved in distilled water, add HLB value 5-6 monoglyceride and HLB The binary compound emulsifying agent of value 12-15 nonionic polyoxyethylene monolaurate, adds lycopene and heats 30-40 DEG C, It is allowed to be completely dissolved, above-mentioned solution is slowly added dropwise into the 4th）Walk in the peony seed oil obtained by extraction and quickly stir, be dispersed into Uniform single-phase oily liquids, is mixed with ultrasonic oscillation；Carnosine, Tea Polyphenols and the lycopene total content in grease（Quality Than）It is not less than 0.01%, obtains the active peony seed oil of antioxidation biology of functionalization.
Its main principle steps：1. by peony seeds by drying, be crushed to certain particle size；2. ethanol and ethyl acetate are micro- Ripple auxiliary pretreatment；3. carry out supercritical CO using ethanol and ethyl acetate as entrainer in certain process conditions2Fluid extraction. 4. ethanol and ethyl acetate are reclaimed in vacuum distillation；5. adding carnosine, Tea Polyphenols and lycopene improves anti-oxidation characteristics.Use the party The major advantage of method is supercritical CO at the process conditions2Peony seed oil obtained by fluid extraction, bioactive substance content Height, loses small, adding has high anti-oxidation characteristic after carnosine, Tea Polyphenols and lycopene, improves storage phase, prevent from going bad.Should The grease of method production can make the matrix oil of cosmetics, contain a large amount of bioactivity and nutriment.
Beneficial effects of the present invention：The present invention provides a kind of objectively high bioactivity cosmetics with antioxidation activity With the production method of oil.This method can efficiently extract high activity peony seed oil with objective, have compared to solvent extraction without molten The characteristic of agent residual, has high anti-oxidation activity by adding composite antioxidant, can be used for the life of cosmetic base oil Production.
Embodiment
The present invention will be described further by following examples.
Embodiment 1.
1）By peony seeds by drying, be crushed to 30 mesh sieve.
2）Ethanol and ethyl acetate submergence are added, Microwave Extraction reaction system is used（Such as the SOS- of French PR OLABO companies 1100 series of products）Handled 5-10 minutes in 2450MHz.
3）Then by said mixture supercritical CO2Equipment（Such as the U.S. morning 300L type in Guangzhou）Extract 3h, extraction conditions：Extraction It is extraction under the conditions of 25MPa, 45~50 DEG C of temperature to take pressure in tank；Separated in knockout drum at pressure 3MPa, 25 DEG C of temperature.
4）The lipidic compounds that 3) step is obtained, are vacuumized at 40-50 DEG C, and ethanol and ethyl acetate are reclaimed in vacuum distillation.
5) inoxidizability will be improved.Carnosine and Tea Polyphenols are dissolved in distilled water, HLB value 5-6 monoglyceride and HLB value is added The binary compound emulsifying agent of 12-15 nonionic polyoxyethylene monolaurate, adds lycopene and heats 30-40 DEG C, make Be completely dissolved, above-mentioned solution is slowly added dropwise into the 3rd）Walk in the peony seed oil obtained by extraction and quickly stir, be dispersed into Even single-phase oily liquids, is mixed with ultrasonic oscillation；Carnosine, Tea Polyphenols and the lycopene total content in grease（Mass ratio） It is not less than 0.01%, obtains the active peony seed oil of antioxidation biology of functionalization.
Embodiment 2.
1）By peony seeds by drying, be crushed to 30 mesh sieve.
2）Ethanol and ethyl acetate submergence are added, Microwave Extraction reaction system is used（Such as the SOS- of French PR OLABO companies 1100 series of products）Handled 8 minutes in 2450MHz.
3）Then by said mixture supercritical CO2Equipment（Such as the U.S. morning 300L type in Guangzhou）Extract 2h, extraction conditions：Extraction It is extraction under the conditions of 25MPa, temperature 45 C to take pressure in tank；Separated in knockout drum at pressure 3MPa, 25 DEG C of temperature.
4）The lipidic compounds that 3) step is obtained, are vacuumized at 50 DEG C, and ethanol and ethyl acetate are reclaimed in vacuum distillation.
5) inoxidizability will be improved.Carnosine and Tea Polyphenols are dissolved in distilled water, HLB value 5-6 monoglyceride and HLB value is added The binary compound emulsifying agent of 12-15 nonionic polyoxyethylene monolaurate, adds lycopene and heats 40 DEG C, be allowed to Fully dissolved, above-mentioned solution is slowly added dropwise into the 4th）Walk in the peony seed oil obtained by extraction and quickly stir, be dispersed into uniform Single-phase oily liquids, is mixed with ultrasonic oscillation；Carnosine, Tea Polyphenols and the lycopene total content in grease（Mass ratio）It is not low In 0.3%, the active peony seed oil of antioxidation biology of functionalization is obtained.

Claims (1)

1. a kind of production method of the cosmetic oil based on peony seeds, it is characterized in that as follows：
1）By peony seeds by drying, be crushed to certain particle size；
2）Appropriate ethanol and ethyl acetate is added in the peony seeds of crushing, Microwave Pretreatment 3-10 minutes makes breaking-wall cell；
3）By step（2）The mixture of gained uses supercritical CO using ethanol and ethyl acetate as entrainer2With pressure in extractor Extracted under the conditions of 20~30MPa of power, 45~50 DEG C of temperature；Then with pressure 3MPa~4MPa, temperature in knockout drum Separated at 25~30 DEG C；
4）By step（3）Grease is obtained, at 45-60 DEG C, pumping high vacuum carries out vacuum distillation and reclaims removing ethanol and ethyl acetate, Obtain peony seed oil；
5）Carnosine and Tea Polyphenols are dissolved in distilled water, HLB value 5-6 monoglyceride and HLB value 12-15 non-ionic polyoxy is added The binary compound emulsifying agent of ethene monolaurate, adds lycopene and heats 30-40 DEG C, be allowed to be completely dissolved, will be above-mentioned molten Liquid is slowly added dropwise into step（4）Stir in peony seed oil obtained by extraction and quickly, be dispersed into uniform single-phase oily liquids, use Ultrasonic oscillation is mixed；Carnosine, Tea Polyphenols and the lycopene mass ratio of total content in grease are not less than 0.01%, obtain work( The active peony seed oil of the antioxidation biology of energyization.
CN201710250986.1A 2017-04-18 2017-04-18 A kind of production method of the cosmetic oil based on peony seeds Withdrawn CN107216942A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108685992A (en) * 2018-07-31 2018-10-23 上品（洛阳）牡丹产业有限公司 A kind of tree peony flower seed oil stoste and preparation method thereof with cell repair function

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108685992A (en) * 2018-07-31 2018-10-23 上品（洛阳）牡丹产业有限公司 A kind of tree peony flower seed oil stoste and preparation method thereof with cell repair function
CN108685992B (en) * 2018-07-31 2021-03-02 上品（洛阳）牡丹产业有限公司 Peony seed oil stock solution with cell repairing function and preparation method thereof

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