KR102025859B1 - Cosmetic or phamaceutical composition comprising herb extract and method for preparing the same - Google Patents

Cosmetic or phamaceutical composition comprising herb extract and method for preparing the same Download PDF

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KR102025859B1
KR102025859B1 KR1020170077485A KR20170077485A KR102025859B1 KR 102025859 B1 KR102025859 B1 KR 102025859B1 KR 1020170077485 A KR1020170077485 A KR 1020170077485A KR 20170077485 A KR20170077485 A KR 20170077485A KR 102025859 B1 KR102025859 B1 KR 102025859B1
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cosmetic composition
extract
skin
weight
mixture
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KR1020170077485A
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Korean (ko)
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KR20180138245A (en
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김운하
김정민
이성주
정은숙
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(주)제로투세븐
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/76Salicaceae (Willow family), e.g. poplar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof

Abstract

The present invention is a peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; relates to a cosmetic or pharmaceutical composition comprising an extract of the mixture comprising as an active ingredient. As a result, the cosmetic or pharmaceutical composition of the present invention includes five herbal extracts, and has excellent skin soothing effects such as reducing transdermal moisture loss and relieving skin redness without irritation to the skin, and lowering skin temperature, improving skin moisturizing, and anti-inflammatory. It is effective and very suitable for use on sensitive skin.

Description

Cosmetic or pharmaceutical composition comprising a herbal extract and a method for producing the same {COSMETIC OR PHAMACEUTICAL COMPOSITION COMPRISING HERB EXTRACT AND METHOD FOR PREPARING THE SAME}

The present invention relates to a cosmetic or pharmaceutical composition comprising a herbal extract and a method for preparing the same, and more particularly, comprising a herbal extract mixed with a plurality of kinds and introducing a pretreatment during preparation of the extract to moisturize skin, strengthen skin barrier, anti-inflammatory, etc. It relates to a cosmetic or pharmaceutical composition comprising a herbal extract having the efficacy of and a preparation method thereof.

As the largest organ of the human body, which occupies about 16% of the body's volume, the skin is in direct contact with the external environment and protects the body from many deadly harmful factors such as temperature, humidity, dust, and ultraviolet radiation. It serves as an important shield. However, infants or sensitive adults are easily damaged by various contaminants, strong ultraviolet rays, and stress, and it takes a long time to recover. Recently, more and more people are complaining of skin irritation such as erythema, swelling, acne, itching, etc. As a result, anti-inflammatory and soothing can reduce skin irritation and inflammation caused by various irritants and reduce skin side effects of modern people. There is an urgent need to develop materials that are effective.

Atopic dermatitis is one of the biggest skin problems of modern sensitive people. These symptoms of atopic dermatitis have severe itching, and in the acute phase the skin is itchy, reddened, swollen, millet-like, small blisters, and scabs sit. In the chronic phase, the skin appears itchy, thickening, thickening, thinning, or rice scales that sit, darken, or become white. Atopic dermatitis usually begins with infantile eczema, commonly referred to as fever. Among the currently used therapeutic drugs, steroids have great anti-inflammatory and immunosuppressive effects, but there are concerns about side effects. Prolonged application may cause atrophy of the skin on the right area, less pigmented skin, bacterial infections, acne and thin skin. In severe cases, hormonal systemic symptoms may occur. Since the incidence of atopic dermatitis is common in infants before the age of five, steroid medications are often applied in small quantities, rather than in large quantities, when steroid ointments with very low hormone levels are needed only for a short period of time.

 Atopic dermatitis is more scary than secondary bacterial infections caused by itching and scratching. The skin of atopic patients is accompanied by bacterial infection as a result of prolonged scraping and drying. More than 90% of atopic patients are infected with Staphylococcus aureus, which may be caused by scratching because the patient is unbearable. It is said to make atopy worse. Therefore, the use of appropriate antibiotics is essential for the treatment of atopy.

 However, since there are concerns about side effects behind the effects of steroids, research on natural products has been actively conducted in recent years. Formulations formulated with natural products have fewer side effects and are generally mild, persistent, biodegradable and environmentally friendly.

 Examples of natural preparations for sensitive skin include cosmetic compositions for improving the healing of atopy skin, including white, purple, echinacea and fermented soybean extracts. , Medicinal herb extract consisting of Angelica, shiho, peppermint, allium and nectarine powder was mixed and cultured with the whole culture solution of leaf fungus mycelium or leaf fungus mycelium, and the leaf fungus mycelium was removed from the culture medium, and the obtained filtrate was contained as an active ingredient. Skin external preparation compositions containing fermented herbal extracts having an excellent effect on skin improvement such as moisturizing, skin irritation relief, atopic improvement effect and anti-inflammatory effect are known.

However, the development of natural preparations without side effects while providing moisturizing effects, anti-inflammatory, and itching relief, which are essential items for treatments for sensitive skin, are still in need.

Korean Patent Registration No. 0431076 Korean Registered Patent No. 1081914

The purpose of the present invention is to provide a herbal extract that is very suitable for use on sensitive skin with excellent skin soothing effects such as reduced transdermal moisture loss and skin redness relief without irritating the skin, and exhibits lower skin temperature, improved skin moisturizing and anti-inflammatory effects. It is to provide a cosmetic or pharmaceutical composition comprising.

Another object of the present invention is to prepare a cosmetic or pharmaceutical composition comprising a mixed extract having an optimal herbal combination in the manufacture of herbal extracts, and to maximize the improvement effect of various skin problems by introducing the dye method in traditional formulations have.

According to one aspect of the invention,

Peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; provides a cosmetic composition comprising an extract of the mixture comprising an active ingredient.

The mixture may be a base treated mixture.

The processing of the base may be a process of immersion after immersing the material in salt water.

The extraction process may be to wash at 80 to 120 ℃.

The extraction process may be performed for 20 to 40 minutes.

The mixed extract, 10 to 40000 parts by weight of mulberry leaves with respect to 100 parts by weight of peach leaves; 10-200000 parts by weight of painting roots; Plum tree fruit 0.5 to 5000 parts by weight; And willow bark 10 to 30000 parts by weight; may include.

The extract of the mixture is at least one extract selected from purified water, glycerin, butylene glycol, hexanediol, methylpropanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, and hexane It may be extracted by a solvent.

The cosmetic composition may have one or more of the following for skin moisture improvement, skin moisturizing enhancement, skin soothing, anti-inflammatory, atopy improvement, itching improvement, and skin temperature reduction.

Extract of the mixture may be included in an amount of 0.0001 to 90% by weight based on the total weight of the cosmetic composition.

According to another aspect of the invention,

Provided is a method for preparing a cosmetic composition comprising extracting a component of a material comprising at least one selected from among peach leaf, mulberry leaf, painting tree root, plum fruit, and willow bark.

The method of preparing the cosmetic composition comprises the steps of: (a) preparing a washed material by washing a material comprising at least one selected from among peach tree leaves, mulberry leaves, painting tree roots, plum tree fruit, and willow bark; (b) preparing the treated material by immersing the washed material in brine and then quenching it; (c) pulverizing the treated material and extracting with an extraction solvent to obtain a filtrate; And (d) concentrating and drying the filtrate to prepare a dried extract powder.

The material of step (a), with respect to 100 parts by weight of peach leaves, mulberry leaves 10 to 40000 parts by weight; 10-200000 parts by weight of painting roots; Plum tree fruit 0.5 to 5000 parts by weight; And willow bark 10 to 30000 parts by weight; may include.

The brine of step (b) may be a concentration of 2% to 4%.

Step (c) may be carried out by submerging at 80 to 120 ° C. for 20 to 40 minutes.

The extraction solvent of step (d) is selected from purified water, glycerin, butylene glycol, hexanediol, methylpropanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, and hexane It may be one or more.

After step (e), dissolving the extract powder in an extraction solvent to prepare an extract; may be further performed.

According to another aspect of the invention,

Peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And it will provide an anti-inflammatory pharmaceutical composition comprising an extract of the mixture including the bark; as an active ingredient.

Also, peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; provides a pharmaceutical composition for atopic improvement or treatment comprising the extract of the mixture comprising as an active ingredient.

Also, peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; It provides a pharmaceutical composition for improving or treating itching, including as an active ingredient extract of the mixture comprising; and willow bark.

According to another aspect of the invention,

Provided is a method of preparing a pharmaceutical composition comprising extracting a component of a material comprising at least one selected from among peach tree leaves, mulberry leaves, painting tree roots, plum tree fruit, and willow bark.

The cosmetic or pharmaceutical composition of the present invention includes five herbal extracts, and has excellent skin soothing effects such as reducing transdermal moisture loss and relieving skin redness without irritation to the skin, and lowering skin temperature, improving skin moisturizing, and anti-inflammatory effect. Very suitable for use on sensitive skin.

In addition, the manufacturing method of the cosmetic or pharmaceutical composition of the present invention produces a mixed extract having the optimal herbal combination in the preparation of herbal extracts, and can maximize the effect of improving the various skin problems by introducing the dye method of the traditional formulation method have.

Figure 1 shows the cell migration effect analysis results of Test Example 1.
Figure 2 shows the analysis results of the moisture content improvement effect of Test Example 2.
Figure 3 shows the results of the analysis of the moisturizing improvement effect of Test Example 3.
Figure 4 shows the anti-inflammatory effect analysis results of Test Example 4.
5 shows the results of analyzing the atopic inhibition effect of Test Example 5.
Figure 6 shows the analysis results of the percutaneous moisture loss amount in the skin calming effect of Test Example 6.
Figure 7 shows the analysis results of the red phase reduction effect in the skin calming effect of Test Example 6.
Figure 8 shows the skin temperature reduction effect analysis results of Test Example 7.

As the invention allows for various changes and numerous embodiments, particular embodiments will be illustrated in the drawings and described in detail in the written description. However, this is not intended to limit the present invention to specific embodiments, it should be understood to include all transformations, equivalents, and substitutes included in the spirit and scope of the present invention. In the following description of the present invention, if it is determined that the detailed description of the related known technology may obscure the gist of the present invention, the detailed description thereof will be omitted.

The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting of the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this application, the terms "comprise" or "have" are intended to indicate that there is a feature, number, step, component, or combination thereof described in the specification, and one or more other features or numbers, It should be understood that it does not exclude in advance the possibility of the presence or addition of steps, components, or combinations thereof.

Hereinafter, the cosmetic composition of the present invention will be described.

The cosmetic composition of the present invention is a peach tree leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; extract of the mixture including as an active ingredient.

It is preferable to use the mixture for the above mixture.

The above treatment means that the water is immersed in the brine and then immersed.

The extraction process is preferably performed for 20 to 40 minutes at 80 to 120 ℃.

The mixed extract, 10 to 40000 parts by weight of mulberry leaves with respect to 100 parts by weight of peach tree leaves; 10-200000 parts by weight of painting roots; Plum tree fruit 0.5 to 5000 parts by weight; And willow bark 10 to 30000 parts by weight; may include.

The peach tree leaves contain nitrile glycosides, 0.07-0.2% tannins, and are rich in aspartic acid, lycopene, and the like.

In the mixed extract, it is preferable to include the leaf portion of the portion of the peach tree, but may be applied to other portions in some cases. The peach tree contains camphorol and its glycosides, tribasic and dioxymonobasic acids, and the seeds contain about 30% emulsine and about 1.5% amigdaline, and the bark of naringenin, triacontane, Pentatricontane and the like, and 40 to 50% of oil (the main components are oleine, palmitine and stearin). In motion therapy, flowers are used for constipation as a diuretic and sensation of diarrhea.

The fruit of the plum tree is called plum, and the fruit is round and twenty yellow. The fruit acid contains lemon acid, malic acid, grape acid, succinic acid, cytosterol, oleanolic acid, cetyl alcohol, and seeds have amigdaline, and the fruit is used as a raw material of lemon acid, and the dried fruit contains 19% lemon acid and 1.5% malic acid. In motion therapy, it is used as a cold astringent medicine, diarrhea, fever medicine, fever medicine, cough medicine and sputum medicine. Plum contains hisperidine and catechin acid, which may be effective for anti-inflammatory skin.

 Mulberry (upper lichen) is a dried mulberry branch of mulberry plants, mulberry (Morus alba, Linne), sagging mulberry (Morus alba for. Peldulls DIPPEL), mountain mulberry (Morus bombycis, Koidzumi), tail mulberry ( Morus bombycis var.Caudatifolia), island mulberry (Morus bombycis var.maritima KOIDZ), and brace mulberry (Morus tiliaefolia, Makino), which are deciduous broad-leaved arbors, horizontally distributed throughout most of Korea, and near mountain villages. It grows wild at the foot of Mt. Normally, the upper limbs have a bitter taste and have the effect of removing anti-inflammatory, diuretic, tonic, sweating and wind, and have been widely used as a herbal medicine for a long time. In particular, mulberry leaves are rich in polyphenols have a high antioxidant effect, rich in lipids, one of the important components of skin barrier components can be effective in strengthening the skin barrier.

 Painting tree (Sophora Japonica L) belongs to the legumes and is distributed in Korea, Japan and China in 25m height. The roots of the painting tree are rich in quercetin, which is effective for moisturizing the skin (Colloids and Surfaces B: Biointerfaces, Volume 123, 1 November 2014, Pages 778-786).

 Willow (Salix koreensis Andersson), also called willow or pot willow, has 3-10% tannins in its bark, flavones, ascorbic acid, and glycoside salicylic acid. It contains up to about 5% salicycin, which is broken down into enzymes by both enzymes. Willow has a component similar to aspirin's main action (Salicyl), which helps reduce heat and relieve inflammation and pain. Willow bark is rich in salicylic acid and can be effective for skin anti-inflammatory.

Extract of the mixture is extracted with an extraction solvent such as purified water, glycerin, butylene glycol, hexanediol, methyl propanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, hexane However, the scope of the present invention is not limited thereto, and various extraction solvents that may be used for extraction of plant material may be used.

The cosmetic composition may be used for skin moisture improvement, skin moisturizing enhancement, skin soothing, anti-inflammatory, atopy improvement, itching improvement, skin temperature reduction and the like.

The cosmetic composition may be an extract of a mixture or a powder obtained by vacuum, concentration and freeze drying of the extract of the mixture, or a combination of the powder and an extractant.

Extract of the mixture may preferably be included in an amount of 0.0001 to 90% by weight relative to the total weight of the cosmetic composition. Because, when the extract content of the mixture is less than 0.0001% by weight, it is difficult to show the skin soothing effect, and when it is 90% by weight or more, the stability on the formulation may be lowered.

Hereinafter, the manufacturing method of the cosmetic composition of the present invention.

The method for producing a cosmetic composition of the present invention includes the step of extracting the components of the material comprising at least one selected from peach tree leaves, mulberry leaves, painting roots, plum fruit, and willow bark.

Specifically, first, the material containing at least one selected from peach tree leaves, mulberry leaves, painting tree roots, plum fruit, and willow bark is washed to prepare a washed material (step a).

The material is 10 to 40000 parts by weight of mulberry leaves with respect to 100 parts by weight of peach leaves; 10-200000 parts by weight of painting roots; Plum tree fruit 0.5 to 5000 parts by weight; And 10 to 30000 parts by weight of willow bark.

Subsequently, the washed material is immersed in brine, and then the salted material is prepared by going through the sieving process (step b).

The brine is preferably in a concentration of 2% to 4%.

The extraction process is preferably carried out at 80 to 120 ℃ for 20 to 40 minutes.

Thereafter, the base material is milled, and then extracted with an extraction solvent to obtain a filtrate (step c).

Extract of the mixture is extracted with an extraction solvent such as purified water, glycerin, butylene glycol, hexanediol, methyl propanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, hexane More preferably purified water, methylpropanediol, hexanediol. The scope of the present invention is not limited thereto, and various extraction solvents that can be used for extraction of plant material can be used.

Thereafter, the filtrate is concentrated and dried to prepare a dried extract powder (step d).

The concentration is preferably by vacuum concentration, the drying may be carried out by freeze drying, but the scope of the present invention is not limited thereto.

Thereafter, the dried extract powder may be dissolved in an extraction solvent to prepare an extract.

Ingredients included in the cosmetic composition of the present invention as an active ingredient includes components commonly used in cosmetic compositions in addition to the active ingredient, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, fragrances, And includes dissolution. Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils It may be formulated as powder foundation, emulsion foundation, wax foundation, but is not limited thereto. More specifically, it may be prepared in the form of facial cleansing, lotion, cream, massage cream, eye cream, essence, gel, pack, spray, powder, sun cream and the like.

 When the formulation of the present invention is a paste, cream or gel, vegetable oil, wax, starch, cellulose, silicone, bentonite, silica, zinc oxide, etc. may be used as a carrier component, and when the formulation is powder, lactose, silica Powders such as aluminum hydroxide, calcium silicate and the like can be used. When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, glycerin, ethyl carbonate, ethyl acetate, propylene glycol, butylene glycol, 1 , 2-hexanediol, glycerol aliphatic ester, sorbitan fatty acid ester.

When the dosage form of the present invention is a suspension, as a carrier component, water, ethanol, liquid diluents such as propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar and the like can be used. In addition, when the formulation is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, methyltaurate, sarcosinate, an alkylamidobetaine, an aliphatic alcohol, a fatty acid glycerol. Ride, vegetable oil or ethoxylated glycerol fatty acid ester and the like can be used.

In addition, the present invention is a peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; provides an anti-inflammatory, pharmaceutical composition comprising an extract of the mixture comprising as an active ingredient.

In addition, the present invention is a peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; provides a pharmaceutical composition for atopic improvement or treatment comprising the extract of the mixture comprising as an active ingredient.

In addition, the present invention is a peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; It provides a pharmaceutical composition for improving or treating itching, including as an active ingredient extract of the mixture comprising; and willow bark.

Since the extract of the mixture is the same as in the cosmetic composition of the present invention described above, the details thereof will be referred to.

In addition, the present invention provides a method for preparing a pharmaceutical composition comprising the step of extracting the components of the material comprising at least one selected from peach tree leaves, mulberry leaves, painting tree roots, plum fruit, and willow bark. .

Since the method of extracting the components is the same as in the method of preparing the cosmetic composition described above, the specific details will be referred to the part.

The pharmaceutical composition of the present invention may be prepared using a pharmaceutically acceptable and physiologically acceptable adjuvant in addition to the active ingredient, wherein the adjuvant includes excipients, disintegrants, sweeteners, binders, coatings, swelling agents, lubricants, lubricants Or a flavoring agent can be used.

The pharmaceutical composition may be preferably formulated into a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers in addition to the active ingredient described above for administration.

The formulation form of the pharmaceutical composition may be a liquid, syrup, juice, suspension, emulsion, drop or the like. For example, if necessary, suitable binders, lubricants, disintegrants and coloring agents may also be included in the mixture. Suitable binders include but are not limited to natural and synthetic gums such as starch, gelatin, glucose or beta-lactose, corn sweeteners, acacia, trackercance or sodium oleate, sodium stearate, magnesium stearate, sodium Benzoate, sodium acetate, sodium chloride and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like.

The pharmaceutical composition of the present invention is preferably by transdermal administration.

EXAMPLE

Example  One: Child  Preparation of Treated Herbal Extracts

(1) material washing

Peach tree leaves, plum fruit, mulberry leaf, painting tree root, willow bark were each screened with a 1kg sample and sufficiently washed to prepare the material.

(2) processing

Next, mix well with 3% brine solution prepared using cleanly purified salt, seal and let it soak well for 3 hours, and then the peach tree, plum fruit, mulberry leaf, Roots of willow and willow bark were dried for 30 minutes at a temperature of about 100 ℃ and then dried in the shade.

(3) herbal extract

It was then milled and passed through a 300 mesh sieve to make the mill fine. Thereafter, ethanol was added so that the final concentration was 60% (v / v) ethanol aqueous solution, refluxed twice for 3 hours, cooled and filtered with Whatman # 2 filter paper. The filtered extract was concentrated under reduced pressure and freeze dried.

Specifically, concentrated under reduced pressure, the filtered extract was concentrated using a rotary vacuum concentrator, and concentrated conditions were concentrated under reduced pressure for 2 hours while putting 600 ml of extract in a 1,000 ml round flask and rotating at 50 ° C. and 1000 rpm at a pressure of 700 mmHg. .

The concentrated solution concentrated under reduced pressure was pre-freezed to lower the temperature to -40 ° C, maintained at -40 ° C for 3 hours, then dropped to -80 ° C through trap freezing, and the vacuum was maintained at 20mTorr, and then- Raise again to 40 ° C. Thereafter, 4 hours at -20 ° C., 1 hour at 0 ° C., 6 hours at 15 ° C., and 2 hours at 30 ° C. were maintained at 20 hours until complete drying, thereby preparing lyophilized powder.

The lyophilized powder was dissolved in 10% methylpropanediol and 2% 1,2-hexanediol to finally have a concentration of 1% (v / v) and 10% (v / v) to prepare a herbal extract. .

Example  2: Hydrothermal  Manufacture of herbal extracts

The herbal extract was prepared in the same manner as in Example 1, except that the treatment was omitted.

[Test Example]

Test Example  1: cell migration ( Cell Migration Effect analysis

In a newborn skin fibroblast (HDFn cell, human dermal fibroblast neonatal cell) 1% (v / v) extract of Example 1 (Principle 1), 1% (v / v) extract of Example 2 (DW 1) After 24 hours, the effect of cell migration was observed.

In order to confirm the cell migration effect of the herbal treatment according to Example 1, the optical microscope image compared with the hydrothermal herbal extract of Example 2 is shown in FIG. According to Figure 1, cell migration evaluation results in HDFn cells compared to the hydrothermal extract of Example 2 extract was further performed the treatment of Example 1 showed that the cell migration effect is more excellent.

Experimental Example  2: analysis of water content improvement effect

1% (v / v) extract of Example 1 (Principal 1), 10% (v / v) extract of Example 1 (Principal 10), 1% of Example 2 (v / v) on human skin keratinocytes ) Extract (DW 1), 10% (v / v) extract of Example 2 (DW 10) was added to evaluate the expression rate of aquaporin (AQP3) and hyaluronic acid (HAS3) synthase genes involved in skin moisture content The results are shown in FIG. “Ra” here means retinol. According to Figure 2, the herbal extract of the present invention has been shown to be effective in improving skin moisture, in particular, the herbal extract of Example 1, which additionally performed the treatment of the treatment to further increase aquaporin and hyaluronic acid synthase gene expression rate appear.

Experimental Example  3: analysis of moisturizing improvement effect

1% (v / v) extract of Example 1 (Principal 1), 10% (v / v) extract of Example 1 (Principal 10), 1% of Example 2 (v / v) on human skin keratinocytes ) Extract (DW 1) and 10% (v / v) extract (DW 10) of Example 2 were evaluated to evaluate the expression rate of the Claudin gene involved in the binding force between filaggrin and keratinocytes involved in keratin differentiation in skin keratinocytes. The results are shown in FIG. According to Figure 3, in the keratinocytes of the skin keratin differentiation involved in the increase in the claudein gene expression rate involved in intercellular cohesion can strengthen the skin barrier and consequently can be expected to improve the skin moisturizing effect.

Experimental Example  4: anti-inflammatory effect analysis

After treating human skin keratinocytes with Poly I: C, an inflammation inducing substance, 1% (v / v) extract of Example 1 (Principle 1) and 10% (v / v) extract of Example 1 (Principal) 10), 1% (v / v) extract of Example 2 (DW 1), 10% (v / v) extract of Example 2 (DW 10), dexamethasone (antihistamine) was added to the gene expression rate of IL-8 Was evaluated and the result is shown in FIG. According to Figure 4, the extract of Example 1 and 10% (v / v) extract of Example 2 was shown to have a superior anti-inflammatory effect compared to dexamethasone, an antihistamine used in the prior art.

Experimental Example  5: Analysis of Atopic Inhibitory Effect

After treating human skin keratinocytes with TSLP (Chemical Compounds that Induce Skin Itching), Poly I: C and IL-4, the 1% (v / v) extract of Example 1 (Principle 1), 10% (v / v) extract of Example 1 (base 10), 1% (v / v) extract of Example 2 (DW 1), 10% (v / v) extract of Example 2 (DW 10) , Dexamethasone (antihistamine) was added to measure the TSLP gene expression rate is shown in Figure 5 the results. According to Figure 5, the herbal extracts of the present invention all have a low TSLP gene expression rate compared to the experimental group (+) without drug treatment, it was confirmed that the atopic inhibitory effect, in particular 10% (v / v) of Example 1 In the extract treatment group, the atopic inhibition was shown to be the best.

Test Example  6: skin soothing effect analysis

Twenty subjects who met the selection criteria were selected and tested to demonstrate skin soothing effect. First, a 1% SLS (sodium laureth sulfate) solution was applied to the skin, and the 1% (v / v) extract of Example 1 was applied to the site where the transdermal moisture loss amount (TEWL) and skin redness (a-value) increased. 2 μl was applied twice for 24 hours, and changes in TEWL and a-value at 24 hours and 48 hours after patching the herbal extracts were observed, and the results are shown in FIGS. 6 and 7, respectively. According to FIGS. 6 and 7, the amount of transdermal moisture loss was significantly decreased at a statistically significant level (p <0.05) compared to the control site after 24 hours and 48 hours, and the skin redness (a-value) was measured in the sample. After 24 hours of patching, it was reduced to a statistically significant level (p <0.05) compared to the control site, indicating that the 1% (v / v) extract of Example 1 had an excellent skin calming effect.

Test Example  7: Skin temperature reduction effect analysis

A human application test was conducted to demonstrate the skin temperature lowering effect. First, 21 subjects meeting the selection criteria were selected, and the 1% (v / v) extract of Example 1 was applied to the subject's face, and the skin temperature was analyzed using a thermal imaging camera. The results are shown in FIG. 8. It was. According to FIG. 8, the site where the sample is applied is determined to have a skin temperature reduction effect by decreasing the skin temperature to a statistically significant level (p <0.05) immediately after application of the sample and before application. All showed a temperature reduction effect of 2.5? On average.

As described above, embodiments of the present invention have been described, but those skilled in the art may add, change, delete, or add elements within the scope not departing from the spirit of the present invention described in the claims. The present invention may be modified and changed in various ways, etc., which will also be included within the scope of the present invention.

Claims (20)

Peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And a willow bark; Cosmetic composition comprising an extract of the mixture comprising as an active ingredient,
The mixture is a mixture treated with salt,
The cosmetic composition is a cosmetic composition, characterized in that it has at least one of the use for improving skin moisture, skin moisturizing enhancement, skin soothing, anti-inflammatory, atopic improvement, itching, and skin temperature reduction.
delete The method of claim 1,
The dyeing treatment is a cosmetic composition, characterized in that the immersion process after immersing the material in salt water.
The method of claim 3,
The steaming process is a cosmetic composition, characterized in that the wash at 80 to 120 ℃.
The method of claim 4, wherein
The steaming process is a cosmetic composition, characterized in that performed for 20 to 40 minutes.
The method of claim 1,
The mixed extract,
About 100 parts by weight of peach tree leaves,
10 to 40000 parts by weight of mulberry leaves;
10-200000 parts by weight of painting roots;
Plum tree fruit 0.5 to 5000 parts by weight; And
Willow bark 10 to 30000 parts by weight; cosmetic composition comprising a.
The method of claim 1,
The extract of the mixture is one or more extracts selected from purified water, glycerin, butylene glycol, hexanediol, methylpropanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, and hexane Cosmetic composition, characterized in that extracted with a solvent.
delete The method of claim 1,
Extract of the mixture is a cosmetic composition, characterized in that contained in an amount of 0.0001 to 90% by weight relative to the total weight of the cosmetic composition.
It is a method of manufacturing a cosmetic composition comprising the step of extracting the components of the material comprising at least one selected from peach leaf, mulberry leaf, painting tree root, plum fruit, and willow bark,
The manufacturing method of the cosmetic composition,
(a) preparing a washed material by washing a material comprising at least one selected from among peach leaf, mulberry leaf, painting tree root, plum fruit, and willow bark;
(b) preparing the treated material by immersing the washed material in brine and then quenching it;
(c) pulverizing the treated material and extracting with an extraction solvent to obtain a filtrate; And
(d) concentrating and drying the filtrate to prepare a dried extract powder;
The cosmetic composition prepared according to the method for preparing the cosmetic composition has one or more uses for improving skin moisture, enhancing skin moisturizing, soothing skin, anti-inflammatory, improving atopy, improving itching, and reducing skin temperature. Method for producing a cosmetic composition, characterized in that.
delete The method of claim 10,
The material of step (a) is
About 100 parts by weight of peach tree leaves,
10 to 40000 parts by weight of mulberry leaves;
10-200000 parts by weight of painting roots;
Plum tree fruit 0.5 to 5000 parts by weight; And
Willow bark 10 to 30000 parts by weight; method of producing a cosmetic composition comprising a.
The method of claim 10,
The brine of step (b) is a method for producing a cosmetic composition, characterized in that the concentration of 2% to 4%.
The method of claim 10,
Step (c) is carried out by steaming at 80 to 120 ℃ for 20 to 40 minutes.
The method of claim 10,
The extraction solvent of step (b) is selected from purified water, glycerin, butylene glycol, hexanediol, methylpropanediol, propanediol, propylene glycol, ethanol, methanol, ethyl acetate, dichloromethane, ethyl ether, and hexane A method for producing a cosmetic composition, characterized in that one or more.
The method of claim 10,
After step (d), dissolving the extract powder in an extracting solvent to prepare an extract; a method of manufacturing a cosmetic composition, characterized in that the further performing.
Peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; including the extract of the mixture as an active ingredient,
The mixture is characterized in that the treated mixture, anti-inflammatory pharmaceutical composition.
Peach leaf; Mulberry leaves; Painting tree roots; Plum fruit; And willow bark; including the extract of the mixture as an active ingredient,
The mixture is characterized in that the treated mixture, atopy improvement or therapeutic pharmaceutical composition.
delete delete
KR1020170077485A 2017-06-19 2017-06-19 Cosmetic or phamaceutical composition comprising herb extract and method for preparing the same KR102025859B1 (en)

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KR100431076B1 (en) 2003-06-16 2004-05-12 주식회사 코스메카코리아 A cosmetic composition containing the mixture of natural plant extracts to recover atopy skin
KR101483440B1 (en) * 2008-05-02 2015-01-19 (주)아모레퍼시픽 Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same
KR101081914B1 (en) 2009-02-02 2011-11-09 한불화장품주식회사 Skin-care agent containing oriental-herb extracts
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