CN1557840A - Polysaccharides compound preparation and method for preparing the same - Google Patents
Polysaccharides compound preparation and method for preparing the same Download PDFInfo
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- CN1557840A CN1557840A CNA2004100127136A CN200410012713A CN1557840A CN 1557840 A CN1557840 A CN 1557840A CN A2004100127136 A CNA2004100127136 A CN A2004100127136A CN 200410012713 A CN200410012713 A CN 200410012713A CN 1557840 A CN1557840 A CN 1557840A
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Abstract
The present invention relates to one kind of polysaccharide preparation and its preparation process. The polysaccharide preparation is prepared with American ginseng and/or ginseng, astragalus root, notoginseng and wolfberry fruit as material, and through ethanol extraction, hot water extraction, concentration of extract liquid, ethanol precipitation, filtering, stoving, crushing to obtain polysaccharide compound; and further ethanol precipitation to eliminate heterosides to obtain polysaccharide preparation with very low heterosides content. The polysaccharide preparation has powerful immune function and obvious health function on valetudinarian, patient in recovering stage, etc.
Description
Technical field
The present invention relates to a kind of polysaccharide compound preparation and preparation method, particularly a kind of is very little polysaccharide compound preparation and preparation method of raw material glycoside compound content with Radix Panacis Quinquefolii and/or genseng, the Radix Astragali, pseudo-ginseng and matrimony vine.
Background technology
Radix Panacis Quinquefolii or genseng, the Radix Astragali and pseudo-ginseng all are the rare traditional Chinese medicines of using always, and these three kinds of medicinal materials mainly are used as medicine with subterraneous root or coring.Special Radix Panacis Quinquefolii or genseng are taken or directly take the capsule after Radix Panacis Quinquefolii or genseng grind carefully after the direct water of people is stewed usually.In fact Radix Panacis Quinquefolii or genseng contain two effective constituents: Radix Panacis Quinquefolii or ginsenoside, Radix Panacis Quinquefolii or panaxan; The Radix Astragali contains three effective constituents: Astragaloside, Radix Astragali flavone and astragalus polysaccharides; Pseudo-ginseng contains three kinds of main components: arasaponin, dencichine and Radix Notoginseng polysaccharide.Because the effect of glycoside compound and polysaccharide compound differs greatly, glycoside compound mainly produces refreshing effect to the mind, fatigue recovery, and memory activates blood circulation and disperses blood clots, and stimulates circulation, and lowering blood glucose and blood pressure prevent cardio-cerebrovascular diseases.Polysaccharide compound mainly is to improve immunologic function and blood fat reducing.And in the root or coring of Radix Panacis Quinquefolii or genseng, use extraction using alcohol, its extract productive rate is at 15-24%, and in the alcohol extract saponin content at 10-30%.And Radix Panacis Quinquefolii or panaxan's content 1-3%.Directly use hot water extraction, its extract productive rate is at 15-20%, and in the water extract saponin content at 10-25%, and Radix Panacis Quinquefolii or panaxan's content 4-10%.Two kinds of method extracts all are the saponin content height, because the saponin content height, people take the effect of only playing saponin behind this extract, and the immune effect of polysaccharide is not obvious.Especially ethanol extraction is based on saponin.Other the Radix Astragali and pseudo-ginseng also are like this.So always the expectation a kind of easy method is arranged, allow this four the flavor Chinese medicine, the main component glycoside compound of Radix Panacis Quinquefolii, genseng, the Radix Astragali and pseudo-ginseng separates with polysaccharide compound.
Nearest disclosed patent CN 1168383A, this patent application document discloses a kind of preparation method of extract: directly use hot water extraction, extract genseng, Radix Panacis Quinquefolii Saponin and polysaccharide with uniting of ethanol sedimentation then, because they have only used one step of water extraction, the relatively poor saponin extraction yield of solubility in genseng, the Radix Panacis Quinquefolii is low, and the saponin content height of aqueous extract causes saponin difficult with separating of polysaccharide, and the ethanol consumption is big.
Summary of the invention
The defective that purpose of the present invention mixes for saponin and polysaccharide in the extract of the Radix Panacis Quinquefolii that overcomes above-mentioned existence and/or genseng, the Radix Astragali and pseudo-ginseng, a kind of polysaccharide compound preparation and preparation method are provided, the present invention uses extraction using alcohol earlier, the two-step approach of water extraction again, saponin extraction yield height not only, and reduced the step of precipitate and separate polysaccharide, the productive rate of polysaccharide and purity have all been improved, and effectively saponin and separation of polysaccharides are come.Usually glycoside compound has certain excitation to be not suitable for children taking, can select appropriate formulation to take according to different human needs like this.The polysaccharide compound preparation that particularly glycoside compound content is very little can allow any crowd take, and comprises children, can improve children immune function.
A kind of polysaccharide compound preparation: be to make by following raw materials by weight:
Radix Panacis Quinquefolii and/or genseng 50%-70% Radix Astragali 20%-30%
Pseudo-ginseng 10-20% matrimony vine 5-10%.
The preparation method of above-mentioned polysaccharide compound preparation: get above-mentioned Radix Panacis Quinquefolii and/or genseng, the Radix Astragali and pseudo-ginseng raw material by certainweight per-cent, and with in it immersion 50-100% alcohol solvent, 50-100 ℃ of following refluxing extraction, filter then, a certain amount of matrimony vine and filter residue adding hot water, treat that boiling reflux is abundant, cooling, filtration reconcentration add 80% ethanolic soln precipitation then, leach precipitation, and the precipitation that will leach is dried, pulverizing, makes polysaccharide compound.
The above-mentioned polysaccharide compound of producing can be made capsule, beverage and oral liquid.
The two-step approach that the present invention carries by the second alcohol and water.Agents useful for same is nontoxic, and is easy to operate, and technology is simple, and used all is general-purpose equipment.The polysaccharide compound that the present invention makes from Radix Panacis Quinquefolii and/or genseng, the Radix Astragali, pseudo-ginseng and matrimony vine four flavor Chinese medicines.Because of glycoside compound content is very little, can allow any crowd take, comprise that youngster is heavy.
Embodiment
Embodiment 1
Canada produces Radix Panacis Quinquefolii trepang coring 70kg, and dried Radix Astragali 20kg is produced in Hebei, and dried pseudo-ginseng 10kg is produced in Yunnan, pulverizes together, adds 80% ethanolic soln, and the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the volume ratio of 80% ethanolic soln is 1: 8, at 1.5m
3Reactor in, back flow reaction is 6 hours under the boiling state, back flow reaction twice is filtered, merging filtrate becomes about 1450 liters of mother liquor (1); Dry wolfberry 10kg is produced together in filter residue and Ningxia, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the weight ratio of water is 1: 10, at 1.5m
3Reactor in, back flow reaction is 6 hours under the boiling state, after the cooling, with plate-and-frame filter press filtrate extract about 760 liters, be concentrated into about 100 liters, add 100 liter 80% ethanolic soln precipitation, leach precipitation, and the precipitation that will leach is dried, pulverizing, gets water-soluble mixing polysaccharide 4.84kg, and wherein this mixing polysaccharide contains glycoside compound 0.35%.It is a kind of be raw material with Radix Panacis Quinquefolii, the Radix Astragali, pseudo-ginseng and matrimony vine, the mixing polysaccharide compounds preparation that glycoside compound content is very little, it has very strong immunologic function, to weak and sickly, easily irritated, serious disease rehabilitation, care of aged, anti-ageing and antitumor etc., particularly the rehabilitation behind cancer patients's chemotherapy radiotherapy all there is tangible effect; About 190 liters of its filtrate merges formation mother liquor (2) about 1640 liters with mother liquor (1), and mother liquor (2) is concentrated into about 100 liters, adds edible silica-gel powder 6kg, shakes up the back spraying drying, obtains 23.8kg mixed glycosides compound formulation.Gained mixing polysaccharide compounds is put into capsule No. 1, every dress 0.1g xeraphium.Recommended dose, mixing polysaccharide compounds capsule is crowd more than 14 years old, day clothes twice each two; More than 3 years old to each one of twice of clothes below 14 years old day.Do the lymphocytic immunization experiment of small white mouse with water-soluble mixing polysaccharide, lymphopoiesis is 10-19 a times of control group, shows that this product has very strong immunologic function.
Embodiment 2
Homemade Radix Panacis Quinquefolii trepang coring 70g, dried Radix Astragali 20g is produced in Hebei, dried pseudo-ginseng 10g is produced in Yunnan, pulverizes together, adds 80% ethanolic soln, the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the volume ratio of 80% ethanolic soln is 1: 8, in 2 liters flask, back flow reaction is 4 hours under the boiling state, twice of back flow reaction, filter, merging filtrate becomes about 1.4 liters of mother liquor (1); Filter residue and Ningxia are produced dry wolfberry 10g together, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the weight ratio of water is 1: 10, in 2 liters flask, back flow reaction is 4 hours under the boiling state, after the cooling, about 720 milliliters of filtrate extract is concentrated into about 100 milliliters, add 100 milliliter 80% ethanolic soln precipitation, about 200 milliliters of filtrate merges formation mother liquor (2) about 1600 milliliters with mother liquor (1), leaches precipitation, with the precipitation oven dry that leaches, pulverize, get water-soluble mixing polysaccharide 5.25g, it is a kind of with Radix Panacis Quinquefolii, the Radix Astragali, pseudo-ginseng and matrimony vine are raw material, the polysaccharide compound preparation that glycoside compound content is very little.Mother liquor (2) is concentrated into dried, obtains 24.4g, gets the glycoside compound preparation.Wherein this mixing polysaccharide contains glycoside compound 0.32%.Do the lymphocytic immunization experiment of small white mouse with water-soluble mixing polysaccharide, lymphopoiesis is 10-17 a times of control group, shows that this product has very strong immunologic function.Product has identical effect with embodiment 1 product.
Embodiment 3
Homemade genseng trepang coring 70g, dried Radix Astragali 20g is produced in Hebei, dried pseudo-ginseng 10g is produced in Yunnan, pulverize together, add 80% ethanolic soln, the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the volume ratio of 80% ethanolic soln is 1: 8, in 2 liters flask, back flow reaction is 4 hours under the boiling state, and back flow reaction twice is filtered, merging filtrate becomes about 1.4 liters of mother liquor (1), dry wolfberry 10g is produced together in filter residue and Ningxia, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medicinal materials and the weight ratio of water is 1: 10, in 2 liters flask, back flow reaction is 4 hours under the boiling state, after the cooling, and about 720 milliliters of filtrate extract, be concentrated into about 100 milliliters, add 100 milliliter 80% ethanolic soln precipitation, about 180 milliliters of filtrate merges formation mother liquor (2) about 1580 milliliters with mother liquor (1); Leach precipitation, with the oven dry of the precipitation that leaches, pulverize, water-soluble mixing polysaccharide 4.86g, it be a kind of be raw material with genseng, the Radix Astragali, pseudo-ginseng and matrimony vine, the polysaccharide compound preparation that glycoside compound content is very little.Mother liquor (2) is concentrated into dried, obtains the glycoside compound preparation of 25.9g.Wherein this mixing polysaccharide contains glycoside compound 0.23%.Do the lymphocytic immunization experiment of small white mouse with water-soluble mixing polysaccharide, lymphopoiesis is 10-21 a times of control group, shows that this product has very strong immunologic function.Product has identical effect with embodiment 1 product.
Claims (6)
1, a kind of polysaccharide compound preparation: be to make by following raw materials by weight:
Radix Panacis Quinquefolii and/or genseng 50%-70% Radix Astragali 20%-30%
Pseudo-ginseng 10-20% matrimony vine 5-10%.
2, according to the preparation method of the described polysaccharide compound preparation of claim 1, it is characterized in that: get above-mentioned Radix Panacis Quinquefolii and/or genseng, the Radix Astragali, pseudo-ginseng raw material by certainweight per-cent, and with in it immersion 50-100% alcohol solvent, 50-100 ℃ of following refluxing extraction, filter then, with a certain amount of matrimony vine and filter residue adding hot water, treat that boiling reflux is abundant, cooling, filtration reconcentration, add 80% ethanolic soln precipitation then, leach precipitation, and the precipitation that will leach is dried, pulverizing, makes polysaccharide compound.
3, according to the preparation method of the described polysaccharide compound preparation of claim 2, it is characterized in that: the Radix Panacis Quinquefolii of adding and/or genseng, the Radix Astragali, pseudo-ginseng raw material are 1 with ethanolic soln bulking value kg/l ratio: 5-1: 15.
4, according to the preparation method of the described polysaccharide compound preparation of claim 2, it is characterized in that: raw material in alcohol solvent refluxing extraction 1-8 hour.
5, according to the preparation method of the described polysaccharide compound preparation of claim 2, it is characterized in that: matrimony vine and filter residue and be 1: 5-1: 15 with the weight ratio of hot water.
6, according to the described polysaccharide compound preparation of claim 1, it is characterized in that: the above-mentioned polysaccharide compound of producing can be made capsule, beverage and oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410012713 CN1288168C (en) | 2004-02-11 | 2004-02-11 | Polysaccharides compound preparation and method for preparing the same |
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| CN 200410012713 CN1288168C (en) | 2004-02-11 | 2004-02-11 | Polysaccharides compound preparation and method for preparing the same |
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| CN1557840A true CN1557840A (en) | 2004-12-29 |
| CN1288168C CN1288168C (en) | 2006-12-06 |
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| CN 200410012713 Expired - Fee Related CN1288168C (en) | 2004-02-11 | 2004-02-11 | Polysaccharides compound preparation and method for preparing the same |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104388223A (en) * | 2014-12-23 | 2015-03-04 | 钟桂英 | Health beer |
| CN104430891A (en) * | 2014-12-23 | 2015-03-25 | 刘淑银 | Health cow milk |
| CN104432240A (en) * | 2014-12-23 | 2015-03-25 | 潘建杰 | Health Wuchang fish ball food |
| CN105296285A (en) * | 2015-11-26 | 2016-02-03 | 丁政然 | Preparation method of ginseng, pseudo-ginseng, and Chinese wolfberry composite fermented wine and product of composite fermented wine |
| CN110420268A (en) * | 2019-09-09 | 2019-11-08 | 张伟华 | A kind of Chinese patent drug assisting in the treatment of lump, cancer |
| CN111729026A (en) * | 2020-08-04 | 2020-10-02 | 淄博市第一医院 | A Chinese medicinal composition for adjuvant treatment of malignant tumor, and its preparation method |
| CN112089770A (en) * | 2020-10-02 | 2020-12-18 | 辽宁泰阳医药科技开发有限公司 | Composition capable of improving immunity and preparation method thereof |
| CN114794477A (en) * | 2022-04-29 | 2022-07-29 | 青海师范大学 | Composition for resisting fatigue and improving immunity and preparation method thereof |
-
2004
- 2004-02-11 CN CN 200410012713 patent/CN1288168C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104388223A (en) * | 2014-12-23 | 2015-03-04 | 钟桂英 | Health beer |
| CN104430891A (en) * | 2014-12-23 | 2015-03-25 | 刘淑银 | Health cow milk |
| CN104432240A (en) * | 2014-12-23 | 2015-03-25 | 潘建杰 | Health Wuchang fish ball food |
| CN105296285A (en) * | 2015-11-26 | 2016-02-03 | 丁政然 | Preparation method of ginseng, pseudo-ginseng, and Chinese wolfberry composite fermented wine and product of composite fermented wine |
| CN110420268A (en) * | 2019-09-09 | 2019-11-08 | 张伟华 | A kind of Chinese patent drug assisting in the treatment of lump, cancer |
| CN111729026A (en) * | 2020-08-04 | 2020-10-02 | 淄博市第一医院 | A Chinese medicinal composition for adjuvant treatment of malignant tumor, and its preparation method |
| CN112089770A (en) * | 2020-10-02 | 2020-12-18 | 辽宁泰阳医药科技开发有限公司 | Composition capable of improving immunity and preparation method thereof |
| CN114794477A (en) * | 2022-04-29 | 2022-07-29 | 青海师范大学 | Composition for resisting fatigue and improving immunity and preparation method thereof |
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| CN1288168C (en) | 2006-12-06 |
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Granted publication date: 20061206 Termination date: 20140211 |