CN105816413A - Black barbary wolfberry fruit procyanidine mask powder and preparation method thereof - Google Patents
Black barbary wolfberry fruit procyanidine mask powder and preparation method thereof Download PDFInfo
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- CN105816413A CN105816413A CN201610368454.3A CN201610368454A CN105816413A CN 105816413 A CN105816413 A CN 105816413A CN 201610368454 A CN201610368454 A CN 201610368454A CN 105816413 A CN105816413 A CN 105816413A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses black barbary wolfberry fruit procyanidine mask powder and a preparation method thereof .The black barbary wolfberry fruit procyanidine mask powder is prepared from 15%-25% of black barbary wolfberry fruit procyanidine powder, 25%-35% of mung bean powder, 15%-30% of coix seed powder, 15%-30% of poria cocos powder and 5%-15% of pearl powder .The invention further provides an extracting preparation technology of black barbary wolfberry fruit procyanidine .The technology comprises the steps that black barbary wolfberry fruit powder is added into a 61% ethanol solution according to the solid-to-liquid ratio of 1:19, and reflux extraction is conducted at 47 DEG C .The black barbary wolfberry fruit procyanidine mask powder prepared by taking the black barbary wolfberry fruit procyanidine as a pure natural additive has the scavenging capacity and reducing capacity on free radicals DPPH, hydroxyl free radicals and superoxide free radicals; meanwhile, functional tests verify that the black barbary wolfberry fruit procyanidine mask powder has the effects of delaying senescence, whitening the skin, removing acne and fading spots, cleaning the skin and the like, is suitable for industrialized production and has the high practicability and development value on the cosmetics industry.
Description
Technical field
The invention mainly relates to the manufacture method of a kind of facial mask powder, specifically, the present invention relates to
A kind of preparing technical field of Lycium ruthenicum Murr. procyanidin facial mask powder.
Background technology
Black Fructus Lycii (Lycium Ruthenium Murr.) is Solanaceae (Solanceae) Lycium
(Lycium L.), is NORTHWEST CHINA area distinctive salt tolerant, drought resisting wild plant, widely distributed,
Aboundresources, " Uigurs medicine will " is recorded, and lycium ruthenicum fruit has kidney tonifying, profit liver, bright
Mesh, stomach invigorating, supplementing the brain, defying age and the effect of stimulating the menstrual flow." Jingzhubencao " is recorded, black Fructus Lycii
Notable for treating heart-heat syndrome, heart disease, menoxenia, menolipsis etc. and drug effect, conduct among the people
Strengthening by means of tonics, depressor are used.
Lycium ruthenicum Murr. contains abundant natural procyanidins, and custom has the title of the king of " procyanidin ", former
Anthocyanidin is the class natural polyphenol compounds being widely present in plant, has water-soluble, nothing
Poison, without characteristics such as allergy, safety are good, be a kind of natural free radical scavenger and antioxidation
Agent, and also defying age, antitumor, antiinflammatory, anticancer change, prevention cardiovascular and cerebrovascular disease and
The physiological functions such as prevention of arterial is atherosis.
Facial film is a kind of carrier of cosmetic health product, utilizes and covers in the of short duration time of face, temporarily
The air in the isolation external world and pollution, improve skin temperature, the pore expansion of skin, promotes that sweat gland divides
Secreting and metabolism, make the oxygen content of skin increase, beneficially skin gets rid of epidermis cell metabolism
Product and the oil substances of accumulation, moisture in facial film penetrates into the horny layer of epidermis, and skin becomes
Obtaining soft, skin light naturally is flexible.Face mask of traditional Chinese medicine is Traditional Chinese medical theory and modern skin protection
The product that theory combines, by being mixed by the various Chinese medicine pulverizing with skin care effect, plays
Improve the effect of skin, be typical case's application of Chinese medicine external.In the modern times, with face mask of traditional Chinese medicine
Become enjoyment and the life style of a kind of fashion.But there is presently no and be specifically designed for the former flower of Lycium ruthenicum Murr.
Blue or green element produces the application of facial mask powder, has widely for exploitation Lycium ruthenicum Murr. procyanidin facial mask powder
Realistic meaning.
Summary of the invention
For having no both at home and abroad about the functional prominent Lycium ruthenicum Murr. procyanidin of specific aim at present
The report of facial mask powder, it is contemplated that in providing a kind of Lycium ruthenicum Murr. procyanidin facial mask powder and system thereof
Preparation Method, former by the Lycium ruthenicum Murr. using Lycium ruthenicum Murr. procyanidin to make as pure natural addictive
Anthocyanidin facial mask powder has removing energy to free radical DPPH, hydroxyl radical free radical and superoxide radical
Power and reducing power, confirmed by functional trial simultaneously, and Lycium ruthenicum Murr. procyanidin facial mask powder has
There are the effects such as slow down aging, whitening, the light speckle of anti-acne, cleaning skin, are suitable to industrialized production,
For cosmetic industry, there is wide applicability and Development volue.
The present invention is achieved through the following technical solutions:
By employing Lycium ruthenicum Murr. procyanidin as pure natural addictive, with Lycium ruthenicum Murr. procyanidin
Powder 15-25%, Semen phaseoli radiati powder 25-35%, lotus-seed-heart powder 15-30%, Poria powder 15-30% and Margarita
Powder 5-15% is as formula, it is provided that the extraction and preparation technique of Lycium ruthenicum Murr. procyanidin, by black Chinese holly
Qi powder adds 61% ethanol solution reflux, extract, with the solid-to-liquid ratio of 1:19, Extracting temperature 47 DEG C,
According to scientific design and optimization technological experiment, the Lycium ruthenicum Murr. procyanidin facial mask powder of preparation is to freedom
Base DPPH, hydroxyl radical free radical and superoxide radical have Scavenging activity and reducing power, simultaneously
Confirmed by functional trial, Lycium ruthenicum Murr. procyanidin facial mask powder have slow down aging, whitening,
The effects such as the light speckle of anti-acne, cleaning skin, are suitable to industrialized production, have for cosmetic industry
Wide applicability and Development volue.
The present invention specifically provides a kind of Lycium ruthenicum Murr. procyanidin facial mask powder, according to percentage by weight
Meter, Lycium ruthenicum Murr. procyanidin facial mask powder contains Lycium ruthenicum Murr. procyanidin powder 15-25%, Semen phaseoli radiati powder
25-35%, lotus-seed-heart powder 15-30%, Poria powder 15-30% and Margarita powder 5-15%.
The effects such as the present invention uses preferred Semen phaseoli radiati powder, has cleaning, cutin of dispelling, antiphlogistic antibacterial.
The present invention uses preferred lotus-seed-heart powder, have whitening moisten, speckle removing, reduce wrinkle etc. and make
With.
The effects such as the present invention uses preferred Poria powder, has freckle removing and whitening, moist skin.
The preferred Margarita powder that the present invention uses, has a Whitening, spot, oil control and acne removal, pore cleanser,
Slow down aging etc. act on.
Meanwhile, the present invention provides the preparation method of above-mentioned Lycium ruthenicum Murr. procyanidin facial mask powder, specifically
Techniques below step is used to prepare:
(1) preparation of Lycium ruthenicum Murr. procyanidin powder: by Lycium ruthenicum Murr. 50 DEG C of drying, pulverized
60 mesh sieves, add 8 times amount petroleum ether immersion 24h and carry out defat, petroleum ether is recovered by filtration, will
Lycium ruthenicum Murr. dried bean noodles is dry, carries by weight adding 61% ethanol solution backflow with the solid-to-liquid ratio of 1:19
Take, Extracting temperature 47 DEG C, for the first time backflow 2h, second time and third time backflow 1h, sucking filtration,
Merging filtrate, is cooled to room temperature, stands 24h, centrifugal rejection filter, obtains clear filtrate, with 1BV/h
Flow velocity join in processed AB-8 macroporous resin column, be washed to effluent clear and bright,
With 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collect eluent, be evaporated to thick
Cream, lyophilization, prepare Lycium ruthenicum Murr. procyanidin powder.
(2) the Lycium ruthenicum Murr. procyanidin powder prepared by above-mentioned steps and Semen phaseoli radiati powder, lotus-seed-heart powder,
Poria powder and crushing pearl cross 200-300 mesh sieve, standby.
(3) by Lycium ruthenicum Murr. procyanidin powder standby for above-mentioned steps mesh sieve, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder carry out mix homogeneously by weight.
(4) flour in step (3) is loaded in aluminium foil bag, every bag of 20-25g, takes out
Vacuum, seals, and room temperature is 20 DEG C of preservations.
Further, the present invention provide use above-mentioned preparation Lycium ruthenicum Murr. procyanidin facial mask powder should
With, use the Lycium ruthenicum Murr. procyanidin facial mask powder of above-mentioned offer, with proper honey, Ovum Gallus domesticus album or cattle
Milk furnishing pasty state facial film, is uniformly applied to face, select the consumption of Mel, Ovum Gallus domesticus album or milk according to
Thick dilute modulation of user preferences facial film, has slow down aging, whitening, the light speckle of anti-acne, cleaning skin
The effects such as skin.
By implementing technical scheme, following beneficial effect can be reached:
(1) the Lycium ruthenicum Murr. procyanidin facial mask powder that the present invention produces, raw material pure natural without
Pollute, performance is gentle, non-stimulated, have no side effect, easy to use, and men and women, old and young are all suitable, suitable
Conjunction industrialized production is processed.
(2) the Lycium ruthenicum Murr. procyanidin facial mask powder of the offer that the present invention provides, passes through the response surface
Method optimizes Lycium ruthenicum Murr. procyanidin and extracts test, Lycium ruthenicum Murr. procyanidin facial mask powder efficacy validation,
The Lycium ruthenicum Murr. procyanidin facial mask powder of preparation is to free radical DPPH, hydroxyl radical free radical and super oxygen certainly
Being had Scavenging activity and reducing power by base, confirmed by functional trial simultaneously, Lycium ruthenicum Murr. is former
Anthocyanidin facial mask powder has the effects such as slow down aging, whitening, the light speckle of anti-acne, cleaning skin, suitable
In industrialized production, for cosmetic industry, there is wide applicability and Development volue.
Accompanying drawing explanation
Fig. 1 is shown as concentration of alcohol and solid-liquid ratio reciprocal action and extracts Lycium ruthenicum Murr. procyanidin
The response surface curve chart of rate.
Fig. 2 is shown as concentration of alcohol and solid-liquid ratio reciprocal action and extracts Lycium ruthenicum Murr. procyanidin
Rate affect contour map.
Fig. 3 is shown as concentration of alcohol and Lycium ruthenicum Murr. procyanidin is carried by Extracting temperature reciprocal action
Take the response surface curve chart of rate.
Fig. 4 is shown as concentration of alcohol and Lycium ruthenicum Murr. procyanidin is carried by Extracting temperature reciprocal action
Take rate affects contour map.
Fig. 5 is shown as Extracting temperature and solid-liquid ratio reciprocal action carries to Lycium ruthenicum Murr. procyanidin
Take the response surface curve chart of rate.
Fig. 6 is shown as Extracting temperature and solid-liquid ratio reciprocal action carries to Lycium ruthenicum Murr. procyanidin
Take rate affects contour map.
Fig. 7 is shown as changing before and after patient smears Lycium ruthenicum Murr. procyanidin facial mask powder hand skin
Situation, wherein, A is for smearing front hand skin conditions, and B is for smearing rear hand skin conditions.
Detailed description of the invention
Below, for embodiment, the present invention is described, but, the present invention is not limited to following enforcement
Example.
In the present invention, material has: Semen phaseoli radiati powder, lotus-seed-heart powder, Poria powder and Margarita powder are purchased from market
Middle common raw materials；The petroleum ether of employing, 61% ethanol solution, AB-8 macroporous resin are all
Reagent that this area is common and material.
All material, reagent and the instrument selected in the present invention are all well known in the art, but not
Limiting the enforcement of the present invention, other reagent more well known in the art and equipment are applied both to this
The enforcement of invention implementation below.
Embodiment one: Lycium ruthenicum Murr. procyanidin facial mask powder
In percentage by weight, Lycium ruthenicum Murr. procyanidin facial mask powder contains Lycium ruthenicum Murr. procyanidin
Powder 15-25%, Semen phaseoli radiati powder 25-35%, lotus-seed-heart powder 15-30%, Poria powder 15-30% and Margarita
Powder 5-15%.
The effects such as the present invention uses preferred Semen phaseoli radiati powder, has cleaning, cutin of dispelling, antiphlogistic antibacterial.
The present invention uses preferred lotus-seed-heart powder, have whitening moisten, speckle removing, reduce wrinkle etc. and make
With.
The effects such as the present invention uses preferred Poria powder, has freckle removing and whitening, moist skin.
The preferred Margarita powder that the present invention uses, has a Whitening, spot, oil control and acne removal, pore cleanser,
Slow down aging etc. act on.
Embodiment two: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and enter
Row defat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight consolidating with 1:19
Liquor ratio adds 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow several times,
Sucking filtration, merging filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate,
Join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, be washed to flow out
Liquid is clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collects eluent, decompression
It is concentrated into thick paste, lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the former flower of Fructus Lycii of preparation
Blue or green element powder 15g, Semen phaseoli radiati powder 25g, lotus-seed-heart powder 15g, Poria powder 15g, Margarita powder 5g pulverize
Pulverizing crosses 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Embodiment three: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and enter
Row defat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight consolidating with 1:19
Liquor ratio adds 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow several times,
Sucking filtration, merging filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate,
Join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, be washed to flow out
Liquid is clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collects eluent, decompression
It is concentrated into thick paste, lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the former flower of Fructus Lycii of preparation
Blue or green element powder 25g, Semen phaseoli radiati powder 35g, lotus-seed-heart powder 30g, Poria powder 30g, Margarita powder 15g pulverize
Pulverizing crosses 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Embodiment four: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and enter
Row defat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight consolidating with 1:19
Liquor ratio adds 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow several times,
Sucking filtration, merging filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate,
Join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, be washed to flow out
Liquid is clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collects eluent, decompression
It is concentrated into thick paste, lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the former flower of Fructus Lycii of preparation
Blue or green element powder 20g, Semen phaseoli radiati powder 30g, lotus-seed-heart powder 22g, Poria powder 22g, Margarita powder 10g pulverize
Pulverizing crosses 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Embodiment five: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and enter
Row defat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight consolidating with 1:19
Liquor ratio adds 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow several times,
Sucking filtration, merging filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate,
Join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, be washed to flow out
Liquid is clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collects eluent, decompression
It is concentrated into thick paste, lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the former flower of Fructus Lycii of preparation
Blue or green element powder 17g, Semen phaseoli radiati powder 27g, lotus-seed-heart powder 18g, Poria powder 18g, Margarita powder 7g pulverize
Pulverizing crosses 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Embodiment six: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and enter
Row defat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight consolidating with 1:19
Liquor ratio adds 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow several times,
Sucking filtration, merging filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate,
Join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, be washed to flow out
Liquid is clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collects eluent, decompression
It is concentrated into thick paste, lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the former flower of Fructus Lycii of preparation
Blue or green element powder 22g, Semen phaseoli radiati powder 32g, lotus-seed-heart powder 27g, Poria powder 27g, Margarita powder 12g pulverize
Pulverizing crosses 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Embodiment seven: the preparation of Lycium ruthenicum Murr. procyanidin facial mask powder
The present invention specifically provides embodiment one to embodiment six Lycium ruthenicum Murr. procyanidin facial mask powder
Preparation method, concrete employing techniques below step prepares:
(1) preparation of Lycium ruthenicum Murr. procyanidin: by Lycium ruthenicum Murr. 50 DEG C of drying, pulverized 60
Mesh sieve, adds 8 times amount petroleum ether immersion 24h and carries out defat, petroleum ether is recovered by filtration, by black Chinese holly
Qi dried bean noodles is dry, by weight adding 61% ethanol solution reflux, extract, with the solid-to-liquid ratio of 1:19,
Extracting temperature 47 DEG C, for the first time backflow 2h, second time and third time backflow 1h, sucking filtration, close
And filtrate, it is cooled to room temperature, stands 24h, centrifugal rejection filter, obtain clear filtrate, with 1BV/h
Flow velocity join in processed AB-8 macroporous resin column, be washed to effluent clear and bright,
With 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collect eluent, be evaporated to thick
Cream, lyophilization, prepare Lycium ruthenicum Murr. procyanidin powder.
(2) the Lycium ruthenicum Murr. procyanidin powder prepared by above-mentioned steps and Semen phaseoli radiati powder, lotus-seed-heart powder,
Poria powder and crushing pearl cross 200-300 mesh sieve, standby.
(3) by Lycium ruthenicum Murr. procyanidin facial mask powder standby for above-mentioned mesh sieve, Semen phaseoli radiati powder, Semen Coicis
Powder, Poria powder and Margarita powder carry out mix homogeneously by weight.
(4) flour in step (3) is loaded in aluminium foil bag, every bag of 20-25g, takes out
Vacuum, seals, and room temperature is 20 DEG C of preservations.
Embodiment eight: prepared by the optimization of Lycium ruthenicum Murr. procyanidin facial mask powder
It is respectively adopted the most different formula as preparation Lycium ruthenicum Murr. procyanidin facial mask powder component:
Formula 1: Fructus Lycii procyanidin powder 15g, Semen phaseoli radiati powder 25g, lotus-seed-heart powder 15g, Poria powder
15g and Margarita powder 5g.
Formula 2: Fructus Lycii procyanidin powder 25g, Semen phaseoli radiati powder 35g, lotus-seed-heart powder 30g, Poria powder
30g and Margarita powder 15g.
Formula 3: Fructus Lycii procyanidin powder 20g, Semen phaseoli radiati powder 30g, lotus-seed-heart powder 22g, Poria powder
22g and Margarita powder 10g.
Formula 4: Fructus Lycii procyanidin powder 17g, Semen phaseoli radiati powder 27g, lotus-seed-heart powder 18g, Poria powder
18g and Margarita powder 7g.
Formula 5: Fructus Lycii procyanidin powder 22g, Semen phaseoli radiati powder 32g, lotus-seed-heart powder 27g, Poria powder
27g and Margarita powder 12g.
Five different formulations of above-mentioned offer are prepared Lycium ruthenicum Murr. according to following technique respectively former
Anthocyanidin facial mask powder:
By the Fructus Lycii procyanidin powder of preparation, Semen phaseoli radiati powder, lotus-seed-heart powder, Poria powder, Margarita powder warp
Cross pulverizing pulverizing and cross 200-300 mesh sieve, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder,
Lotus-seed-heart powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet irradiation sterilization of mixing
5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, and room temperature is 20 DEG C of guarantors
Deposit.
Response phase method optimizes the extraction of Lycium ruthenicum Murr. procyanidin to be tested:
Response surface experiments factor and water-glass see table 1.
Table 1: response surface experiments factor and water-glass
Table 2: response surface experiments design and result
Response surface experiments design and result:
Design of experiment analysis is carried out, its knot according to Box-Benhnken center combination design principle
Fruit is shown in Table 2.The experiment to table 2 of the method for polynomial fitting is used by Design Expert8.0.6
Data are fitted, and obtain Lycium ruthenicum Murr. extraction ratio Y to concentration of alcohol (A), solid-liquid ratio (B),
The multinomial regression model of secondary of extraction temperature (C) is:
Y=10.31+0.20A-0.12B-0.29C-0.26AB+0.16AC+0.30BC-0.48A2-0.48B2-0.29C2
In response surface analysis, each factor reciprocal action is referring specifically to accompanying drawing 1 to accompanying drawing 6, by above-mentioned
Optimization experiment obtains:
Use Lycium ruthenicum Murr. in 50 DEG C of drying, pulverizing, add 8 times amount petroleum ether immersion 24h and take off
Fat, is recovered by filtration petroleum ether, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight the solid-to-liquid ratio with 1:19
Add 61% ethanol solution reflux, extract, Extracting temperature 47 DEG C, through backflow, sucking filtration several times,
Merging filtrate, is cooled to room temperature, stands 24h, centrifugal rejection filter, obtains clear filtrate, with 1BV/h
Flow velocity join in processed AB-8 macroporous resin column, be washed to effluent clear and bright,
With 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collect eluent, be evaporated to thick paste,
Lyophilization, it is thus achieved that Lycium ruthenicum Murr. procyanidin powder, by the Lycium ruthenicum Murr. procyanidin powder of preparation
15-25%, Semen phaseoli radiati powder 25-35%, lotus-seed-heart powder 15-30%, Poria powder 15-30% and Margarita powder
5-15%, crosses 200-300 mesh sieve through pulverizing pulverizing, then by above-mentioned Lycium ruthenicum Murr. procyanidin powder,
Semen phaseoli radiati powder, lotus-seed-heart powder, Poria powder and Margarita powder uniformly mix, by the flour ultraviolet of mixing
Radiation sterilizing 5-10min, obtains Lycium ruthenicum Murr. procyanidin facial mask powder, packaging, seals, room temperature
20 DEG C of preservations.
Embodiment nine: the antioxidation of Lycium ruthenicum Murr. procyanidin facial mask powder
Lycium ruthenicum Murr. prepared by the different formulations that detection above-described embodiment one to embodiment seven provides is former
Anthocyanidin facial mask powder to free radical DPPH, hydroxyl radical free radical, the Scavenging activity of superoxide radical,
And the reducing power of Lycium ruthenicum Murr. procyanidin.
Using Vc as comparison, the antioxidation of the Lycium ruthenicum Murr. procyanidin facial mask powder that the present invention provides
Ability is less than Vc, but Lycium ruthenicum Murr. procyanidin facial mask powder is to free radical DPPH, hydroxyl certainly
By base, superoxide radical Scavenging activity and certain reducing power.
Result: test result indicate that, the Lycium ruthenicum Murr. procyanidin facial mask powder that the present invention provides is obvious
To free radical DPPH, hydroxyl radical free radical, superoxide radical Scavenging activity and reducing power.
Embodiment ten: the application effect of Lycium ruthenicum Murr. procyanidin facial mask powder
1. the object of observation
Being sampled totally 504 example by market by above-mentioned Lycium ruthenicum Murr. procyanidin facial mask powder, sample is originated
It is the Lycium ruthenicum Murr. usually using the above embodiment of the present invention one to embodiment eight preparation to provide former
Anthocyanidin facial mask powder.Wherein male 198 example, women 306 example.Observation group's max age 73
Year, minimal ages 3 years old.
2. application process
Lycium ruthenicum Murr. prepared by the different formulations using above-described embodiment one to embodiment seven to provide is former
During anthocyanidin facial mask powder, open facial mask powder packaging bag finished product and be positioned in heavy caliber container, respectively
Use proper honey, Ovum Gallus domesticus album or milk furnishing pasty state facial film；Uniformly it is applied to face, treats 20-30min
After, clean face with cold water.
3. the result:
Compare according to effective, effective and null criterion, observe it by statistical procedures poor
Different significance.Result is notable substantially sample 298 example, effective 194 examples, invalid 12 examples,
Total effective rate 97.62%.
It is simple that the present invention prepares Lycium ruthenicum Murr. procyanidin facial mask powder method, it is easy to operation, produces and takes
With low.Lycium ruthenicum Murr. procyanidin facial mask powder provided by the present invention is pure Chinese medicinal preparation, through clinic
And market watch, without other any chemicals and toxic and side effects.The present invention can be by having in raw material
The effect substantially all extraction of nutritional labeling is not damaged, and concentration is big, facilitate patient to use and
Absorbing, external application is without allergy and skin foaming phenomena, and patient is also without any untoward reaction.
Patient opens XX, people from Urumchi, Xinjiang Uygur Autonomous Regions, and man 23 years old, because of 1 year
Cause face to stay after anti-acne treatment and be dispersed in pox print.Use the former cyanine of Lycium ruthenicum Murr. that the present invention provides
Element facial mask powder, 1000g altogether, three-times-weekly, use facial mask powder to mix with 60g Mel every time
Furnishing pasty state, spreads on the face, sees that pox print disappears after using three months, and it is white that complexion replys profit.
Patient Lee XX, Tianshui city people, female, 30 years old.Extended sleep is the best, during sleep
Between short, face is sallow, although life-time service skin-lightening cosmetic does skin nursing, but effect is not
Good.The Lycium ruthenicum Murr. procyanidin facial mask powder that the use present invention provides, 500g altogether, on every Wendesdays
Secondary, use facial mask powder and 50g milk mixing furnishing pasty state every time, spread on the face, use two
After Yue, face recovers profit in vain.
Patient Huang XX, people from Jiangsu, female, 40 years old.Working principle, hand skin is pitch-dark.
The Lycium ruthenicum Murr. procyanidin facial mask powder row using the present invention to provide smears test, smears one every day
Secondary, the time is one week, observes the situation of change of patient's Huang XX hand skin.Result sees attached
Fig. 7, the whitening effect that patient Huang XX smears rear hand skin is the most obvious.
The Lycium ruthenicum Murr. procyanidin facial mask powder of the offer that the present invention provides in sum, by response
Face method optimizes the extraction test of Lycium ruthenicum Murr. procyanidin, Lycium ruthenicum Murr. procyanidin facial mask powder effect is tested
Card, the Lycium ruthenicum Murr. procyanidin facial mask powder of preparation is to free radical DPPH, hydroxyl radical free radical and surpasses
Oxygen-derived free radicals has Scavenging activity and reducing power.
Confirmed by functional trial simultaneously, the Lycium ruthenicum Murr. procyanidin facial film of above-mentioned offer is provided
Powder, with proper honey, Ovum Gallus domesticus album or milk furnishing pasty state facial film, is uniformly applied to face, selects honeybee
Honey, Ovum Gallus domesticus album or milk consumption according to thick dilute modulation of user preferences facial film, have slow down aging,
The effects such as whitening, the light speckle of anti-acne, cleaning skin, are suitable to industrialized production, for cosmetic conduct
Industry has wide applicability and Development volue.
As it has been described above, the present invention can preferably be realized, the above embodiments are only to this
Bright preferred implementation is described, and is not defined the scope of the present invention, is not taking off
On the premise of the present invention designs spirit, the those of ordinary skill in the art technical side to the present invention
The various changes and improvements that case is made, all should fall in the protection domain that present invention determine that.
Claims (3)
1. a Lycium ruthenicum Murr. procyanidin facial mask powder, it is characterised in that in percentage by weight, facial mask powder contains Lycium ruthenicum Murr. procyanidin powder 15-25%, Semen phaseoli radiati powder 25-35%, lotus-seed-heart powder 15-30%, Poria powder 15-30% and Margarita powder 5-15%.
2. the preparation method of a Lycium ruthenicum Murr. procyanidin facial mask powder according to claim 1, it is characterised in that concrete employing techniques below step prepares:
(1) preparation of Lycium ruthenicum Murr. procyanidin powder: by Lycium ruthenicum Murr. 50 DEG C of drying, pulverized 60 mesh sieves, add 8 times amount petroleum ether immersion 24h and carry out defat, petroleum ether is recovered by filtration, by dry for Lycium ruthenicum Murr. dried bean noodles, by weight adding 61% ethanol solution reflux, extract, with the solid-to-liquid ratio of 1:19, Extracting temperature 47 DEG C, backflow 2h for the first time, second time and third time backflow 1h, sucking filtration, merging filtrate, it is cooled to room temperature, stand 24h, centrifugal rejection filter, obtain clear filtrate, join in processed AB-8 macroporous resin column with the flow velocity of 1BV/h, it is washed to effluent clear and bright, with 6BV 60% ethanol with the flow velocity eluting of 1BV/h, collect eluent, it is evaporated to thick paste, lyophilization, prepare Lycium ruthenicum Murr. procyanidin powder；
(2) Lycium ruthenicum Murr. procyanidin powder above-mentioned steps prepared crosses 200-300 mesh sieve with Semen phaseoli radiati powder, lotus-seed-heart powder, Poria powder and crushing pearl, standby；
(3) standby for above-mentioned steps mesh sieve Lycium ruthenicum Murr. procyanidin powder, Semen phaseoli radiati powder, lotus-seed-heart powder, Poria powder and Margarita powder are carried out mix homogeneously by weight；
(4) flour in step (3) is loaded in aluminium foil bag, every bag of 20-25g, evacuation, seal, room temperature is 20 DEG C of preservations.
3. the application of Lycium ruthenicum Murr. procyanidin facial mask powder as claimed in claim 1, it is characterised in that the Lycium ruthenicum Murr. procyanidin facial mask powder using claim 1 to provide, with Mel, Ovum Gallus domesticus album or milk furnishing pasty state facial film, is uniformly applied to face.
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| CN110793963B (en) * | 2019-11-12 | 2022-04-22 | 光明乳业股份有限公司 | Acid indicator based on lycium ruthenicum anthocyanin extract and application thereof |
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