CN103751530A - Extract of traditional Chinese medicine composite with anti-allergy effect, and application of extract - Google Patents
Extract of traditional Chinese medicine composite with anti-allergy effect, and application of extract Download PDFInfo
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- CN103751530A CN103751530A CN201410065740.3A CN201410065740A CN103751530A CN 103751530 A CN103751530 A CN 103751530A CN 201410065740 A CN201410065740 A CN 201410065740A CN 103751530 A CN103751530 A CN 103751530A
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Abstract
The invention discloses an extract of a traditional Chinese medicine composite with an anti-allergy effect. The traditional Chinese medicine composite comprises the following traditional Chinese medicine components by weight percentage: 10-40% of cortex dictamni, 5-30% of lithospermum erythrorhizon, 5-30% of radix saposhnikoviae, 5-30% of Chinese angelica, 5-20% of radix polygonati officinalis, and 5-25% of liquorice. After the traditional Chinese medicine composite is subjected to heating and reflux extraction, an extracting solution is condensed and then passes through a macroporous resin column; elution is performed by an alcohol solution; an eluant is depressurized and condensed; dilution is performed by butanediol; and then the extract of the traditional Chinese medicine composite is obtained. The extract of the traditional Chinese medicine composite has good functions of restraining skin allergy and relieving skin itching, and can be applied to external skin agents such as cosmetics.
Description
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Technical field
The present invention relates to a kind of Chinese medicine composition extract with antiallergic effect, this Chinese medicine composition extract has good inhibition skin allergy and the antipruritic function of skin, can be applied to be applied in the skin preparations for extenal use such as cosmetics.
Background technology
Skin allergy is a kind of common irritated form, according to investigations, approximately has 20% people to have skin allergy phenomenon.Easily the skin of skin allergy claims again sensitive skin.Various exopathogenic factors cause skin to produce anaphylaxis, there will be redness, itch, the abnormal phenomena such as decortication and allergic dermatitis.The sickness rate of China's skin allergy is very high, particularly in autumn and winter season, and xerosis cutis, a lot of people can show the skin allergy symptoms such as skin pruritus.
The pathogenic factor of skin allergy comprises intrinsic factor and extrinsic factor two broad aspect: intrinsic factor are exactly that itself has allergic constitution.Extrinsic factor is a lot, comprises diet, inhalation (inhalatio), weather, contact allergy thing factor etc.Cosmetics are exactly the contact allergy thing that a kind of common meeting causes skin allergy, and some consumers are after making to apply some make up, and skin occurs uncomfortable, as rubescent, twinge, dermatitis symptom.What have is occurring with latter several minutes, have in a few hours, even after a couple of days, occur.This is the material that easily causes skin allergy owing to containing some in cosmetics, as antiseptic, essence, surfactant and some functional components etc.In order to reduce the zest of these anaphylaxis materials to skin, in cosmetic formulations, often need to add anti-sensitizer.Conventional cosmetics anti-sensitizer has glycyrrhizic acid dipotassium, ɑ-bisabolol, Herba portulacae extract etc.These anti-sensitizers all have certain defect, as glycyrrhizic acid dipotassium can increase the ion concentration in cosmetics, make cosmetics unstable; ɑ-bisabolol itself is just irritant, and antiallergic effect is general; Herba portulacae extract has photosensitivity reaction, has security risk, and single Chinese medicine result of use of planting is not good.In order to overcome the deficiency of these anti-sensitizers, the present invention adopts the configuration principle of Chinese medicine " monarch " to invent a kind of Chinese medicine composition with antiallergic effect.
Summary of the invention
The object of the invention is, in order to overcome the defect of the cosmetics anti-sensitizer of current use, provides a kind of extract of Chinese medicine composition, and the extract of this Chinese medicine composition has antiallergic effect, and has the advantages such as nontoxic, safe.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
A Chinese medicine composition with antiallergic effect, is characterized in that the component that comprises following percentage by weight: Cortex Dictamni 10-40%; Radix Arnebiae (Radix Lithospermi) 5-30%; Radix Saposhnikoviae 5-30%; Radix Angelicae Sinensis 5-30%; Rhizoma Polygonati Odorati 5-20%; Radix Glycyrrhizae 5-25%.
For obtaining the extract of above-mentioned Chinese medicine composition, the present invention has adopted following technical scheme: by the Cortex Dictamni in above-mentioned Chinese medicine composition, Radix Arnebiae (Radix Lithospermi), Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Polygonati Odorati, Radix Glycyrrhizae is pulverized, mix homogeneously, add extraction solvent, heating and refluxing extraction 1-3 time, merge extractive liquid, under 60 ℃ of conditions, be evaporated to without alcohol taste, go up again D101 type or AB-8 type macroporous resin column purification, the ethanol elution that collection mass fraction is 30%-80%, being evaporated to medical material is 1: 0.5～1: 5 with medicinal liquid ratio, adding mass fraction is the butanediol dissolving of 10%-60%, filter, make Chinese medicine composition extract.The extraction solvent using in the present invention can adopt water, ethanol, alcohol-water mixed solution.
The second object of the present invention be by this Chinese medicine composition for cosmetics, make stable in properties, the respond well cosmetics of antiallergic.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: the application by the extract of above-mentioned Chinese medicine composition in preparing cosmetics, it is characterized in that the extract that contains above-mentioned Chinese medicine composition in cosmetics, its consumption is 0.05-20%, and preferable amount is 1-10%.Except containing above-mentioned Chinese medicine composition extract, can suitably add as required the common composition of cosmetics, as matrix components such as wetting agent, emollient, water, emulsifying agent, antioxidant, essence.
Dosage form for cosmetics is not particularly limited, and can be water preparation, gel, emulsion, cream frost etc.
Beneficial effect of the present invention: the present invention carries out the design of Chinese medicine composition according to the theory of Chinese medical science of monarch, the Cortex Dictamni in Chinese medicine composition of the present invention is monarch, have dispel the wind, the effect of dampness, heat clearing away, removing toxic substances; Radix Arnebiae (Radix Lithospermi) and when being classified as minister, that Radix Arnebiae (Radix Lithospermi) has is antipruritic, invigorate blood circulation, removing the necrotic tissue and promoting granulation, removing toxic substances pain relieving and anti-inflammatory effect, and Radix Angelicae Sinensis has the effect of blood circulation promoting and blood stasis dispelling; Radix Saposhnikoviae and Rhizoma Polygonati Odorati are assistant, and Radix Saposhnikoviae has expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, itching-relieving efficacies, and Rhizoma Polygonati Odorati has clearing heat and moistening dryness, yin nourishing and relieves dizziness, high fever, infantile convulsions, epilepsy, etc., nourishes QI and blood, flat benefit and moisten, hold concurrently and remove the effect of wind heat; Radix Glycyrrhizae is for making, and coordinating the actions of various ingredients in a prescription has QI invigorating invigorating middle warmer, relaxes the effect of the property of medicine.All medicines share above, Synergistic, have well dispel the wind, antipruritic, invigorate blood circulation, moisturizing, anti-inflammatory effect, thereby reach skin antiallergic object.
The specific embodiment
By specific embodiment, come below that the present invention is further illustrated, but these embodiment are just in order to illustrate, are not limitations of the present invention.
the preparation of embodiment 1 Chinese medicine composition (I) and extract thereof
Get Cortex Dictamni 25g, Radix Arnebiae (Radix Lithospermi) 15g, Radix Saposhnikoviae 20g, Radix Angelicae Sinensis 15g, Rhizoma Polygonati Odorati 15g, Radix Glycyrrhizae 10g, pulverizes, mix homogeneously, adding mass fraction is 70% ethanol 1L, heating and refluxing extraction twice, each 1.5h, merge extractive liquid,, under 60 ℃ of conditions, be evaporated to without alcohol taste, upper AB-8 type macroporous resin column purification, collecting mass fraction is 70% ethanol elution part, concentrating under reduced pressure obtains 60mL concentrated solution, add again 40mL butanediol, filter, make the extract of 100mL Chinese medicine composition, its solid content is 9.6%, and pH value is 5.84.
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embodiment 2?
the preparation of Chinese medicine composition (II) and extract thereof
Get Cortex Dictamni 20g, Radix Arnebiae (Radix Lithospermi) 12g, Radix Saposhnikoviae 18g, Radix Angelicae Sinensis 14g, Rhizoma Polygonati Odorati 20g, Radix Glycyrrhizae 16g, pulverizes, mix homogeneously, adding mass fraction is 60% ethanol 1.2L, heating and refluxing extraction three times, each 1h, merge extractive liquid,, under 60 ℃ of conditions, be evaporated to without alcohol taste, upper AB-8 type macroporous resin column purification, the ethanol elution part that collection mass fraction is 70%, concentrating under reduced pressure obtains 50mL concentrated solution, add again 50mL butanediol, filter, make the extract of 100mL Chinese medicine composition, its solid content is 10.5%, and pH value is 5.92.
embodiment 3?
the preparation of Chinese medicine composition (III) and extract thereof
Get Cortex Dictamni 22g, Radix Arnebiae (Radix Lithospermi) 15g, Radix Saposhnikoviae 17g, Radix Angelicae Sinensis 13g, Rhizoma Polygonati Odorati 16g, Radix Glycyrrhizae 17g, pulverizes, mix homogeneously, adding mass fraction is 50% ethanol 1.5L, heating and refluxing extraction twice, each 1.5h, merge extractive liquid,, under 60 ℃ of conditions, be evaporated to without alcohol taste, upper D101 type macroporous resin column purification, collecting mass fraction is 60% ethanol elution part, concentrating under reduced pressure obtains 80mL concentrated solution, add again 20mL butanediol, filter, make the extract of 100mL Chinese medicine composition, its solid content is 9.8%, and pH value is 5.71.
the inhibition test of experimental example 1 Chinese medicine composition extract to hyaluronidase
Hyaluronidase is hyaluronic hydrolytic enzyme, it and inflammation, irritated exists close contacting.By measuring the suppression ratio of Chinese medicine composition extract to hyaluronidase, can indirectly determine the inhibitory action of Chinese medicine composition to skin allergy.
Testing program: adopt Elson-Morgan improved method extract to carry out the inhibitory action test method of hyaluronidase.Get 0.1mL 0.25mmol/LCaCl
2solution and 37 ℃ of heat insulating culture 20min of 0.5mL hyaluronidase liquid: the Chinese medicine composition extract 0 that adds respectively embodiment 1-3 to prepare, 0.5, 1.0, 1.5, 2.0mL, continue 37 ℃ of heat insulating culture 20min: add 37 ℃ of insulation 30min of 0.5mL hyaluronate sodium liquid, room temperature is placed 5min: add 0.1mL 0.4mol/L NaOH solution and 0.5mL acetylacetone,2,4-pentanedione solution, be placed in after boiling water bath heats 15min and with frozen water, wake up with a start cooling 5min immediately: add Ehrlich's reagent 1 mL, and be diluted to 5mL with dehydrated alcohol, place 20min colour developing, with its absorbance of spectrophotometric determination.
Be calculated as follows the suppression ratio of extract to hyaluronidase:
Suppression ratio (%)=(A-B)-(C-D) ］/(A-B) * 100%
In formula, A is the absorbance of contrast solution (hyaluronate sodium+hyaluronidase+deionized water); B is the absorbance of contrast blank solution (hac buffer+deionized water); C is the absorbance of sample solution (potassium hyaluronate+hyaluronidase+extract solution); D is the absorbance of sample blank solution (hac buffer+extract solution).
Result of the test is shown in Table 1.
Table 1
Table 1 result shows, Chinese medicine composition extract of the present invention has good inhibitory action to hyaluronidase, illustrates that Chinese medicine composition extract of the present invention has good antiallergic effect.
embodiment 4 is containing the antiallergic facial film of Chinese medicine composition extract
Table 2 provides the antiallergic facial mask liquid formula of the extract that contains Chinese medicine composition of the present invention (I).
Table 2
| Material title | Mass fraction/% |
| Water | Surplus |
| Glycerol | 3.00 |
| Butanediol | 5.00 |
| Hydroxyethyl-cellulose | 0.15 |
| Hyaluronate sodium | 0.02 |
| Trehalose | 1.00 |
| Pantothenylol | 0.50 |
| Carbomer | 0.10 |
| Aminomethyl propanol | 0.05 |
| Ethanol | 4.00 |
| The extract of Chinese medicine composition (I) | 6.00 |
| PEG-40 castor oil hydrogenated | 0.10 |
| Essence | 0.02 |
| Phenoxyethanol | 0.50 |
| Methyl hydroxybenzoate | 0.30 |
| Propyl hydroxybenzoate | 0.05 |
Preparation method: essence is mixed homogeneously with PEG-40 castor oil hydrogenated, make solubilising essence.All the other substance dissolves in table 2, in 80 ℃ of water, are stirred while being cooled to 45 ℃ and add solubilising essence, be cooled to room temperature, can make facial mask liquid.To apply face film special non-woven fabric and soak by facial mask liquid, and can make and apply face antiallergic facial film.
embodiment 5 is containing the antiallergic protective skin cream of Chinese medicine composition extract
Table 3 provides the antiallergic prescription for skin cream of the extract that contains Chinese medicine composition of the present invention (I).
Table 3
Preparation method: 80 ℃ of dissolving mix homogeneously of A component, 80 ℃ of dissolving mix homogeneously of B component, add B component before Cyclomethicone emulsifying, during emulsifying, B component adds A component homogenizing 5 minutes, while being cooled to 50 ℃, add C component homogenizing 2 minutes, after ageing 24h, pack.
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embodiment 6 is containing the antiallergic emulsion of Chinese medicine composition extract
Table 4 provides the antiallergic emulsion formulations of the extract that contains Chinese medicine composition of the present invention (I).
Table 4
Preparation method: 80 ℃ of A components are dissolved mix homogeneously, 80 ℃ of B components are dissolved mix homogeneously, before emulsifying, C are added to B component, and during emulsifying, A component adds B component homogenizing 5 minutes, adds D homogenizing 2 minutes while being cooled to 50 ℃, after ageing 24h, pack.
the common facial film of comparative example 1
Table 5 provides common facial mask liquid formula.
Table 5
| Material title | Mass fraction/% |
| Water | Surplus |
| Glycerol | 3.00 |
| Butanediol | 5.00 |
| Hydroxyethyl-cellulose | 0.15 |
| Hyaluronate sodium | 0.02 |
| Trehalose | 1.00 |
| Pantothenylol | 0.50 |
| Carbomer | 0.10 |
| Aminomethyl propanol | 0.05 |
| Ethanol | 4.00 |
| PEG-40 castor oil hydrogenated | 0.10 |
| Essence | 0.02 |
| Phenoxyethanol | 0.50 |
| Methyl hydroxybenzoate | 0.15 |
| Propyl hydroxybenzoate | 0.05 |
Preparation method: essence is mixed homogeneously with PEG-40 castor oil hydrogenated, make solubilising essence.All the other substance dissolves in table 5, in 80 ℃ of water, are stirred while being cooled to 45 ℃ and add solubilising essence, be cooled to room temperature, can make facial mask liquid.To apply face film special non-woven fabric and soak by facial mask liquid, and can make and apply the common facial film of face.
experimental example 2 skin irritation evaluation experimentals
Respectively the common facial film of the antiallergic facial film of embodiment 4 preparations and comparative example 1 preparation is carried out to human body evaluation on probation.Choose 80 volunteers, men and women half and half.Be divided into 2 groups, every group of 40 people (every group of 20 male, 20 women).2 groups are used respectively the antiallergic facial film of embodiment 4 preparations and the common facial film of comparative example 1 preparation.Architrave once, is opened half an hour after facial film every night, according to table 6 standard, checks.Carried out altogether experiment in 10 days.Result is as shown in table 7.
Table 6
| Grade | Standard of perfection |
| 0 | Negative reaction: non-stimulated, without erythema |
| 1 | Suspicious reaction: slight erythema |
| 2 | Weak positive reaction: erythema |
| 3 | Strong positive reaction: erythema, pimple, vesicle |
| 4 | Extremely strong positive reaction: serious edema, bulla |
Table 7
| Irritated grade | Comparative example 1 | Embodiment 4 |
| 0 grade number | 75 | 80 |
| 1 grade number | 5 | 0 |
| 2 grade numbers | 1 | 0 |
| 3 grade numbers | 0 | 0 |
| 4 grade numbers | 0 | 0 |
As seen from the results in Table 7, do not add the common facial film allergic phenomena of comparative example 1 preparation of Chinese medicine composition extract of the present invention, and there is not allergic phenomena in the antiallergic facial film that has added embodiment 4 preparations of Chinese medicine composition extract of the present invention.
Claims (2)
1. an extract with the Chinese medicine composition of antiallergic effect, is characterized in that the Chinese medicinal components that comprises following percentage by weight: Cortex Dictamni 10-40%, Radix Arnebiae (Radix Lithospermi) 5-30%, Radix Saposhnikoviae 5-30%, Radix Angelicae Sinensis 5-30%, Rhizoma Polygonati Odorati 5-20%, Radix Glycyrrhizae 5-25%; The manufacture method of the extract of Chinese medicine composition is: Cortex Dictamni, Radix Arnebiae (Radix Lithospermi), Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Polygonati Odorati, Radix Glycyrrhizae are pulverized, mix homogeneously, add extraction solvent, heating and refluxing extraction 1-3 time, merge extractive liquid,, under 60 ℃ of conditions, be evaporated to without alcohol taste, go up again D101 type or AB-8 type macroporous resin column purification, the ethanol elution that collection mass fraction is 30%-80%, being evaporated to medical material is 1: 0.5～1: 5 with medicinal liquid ratio, adding mass fraction is the butanediol dissolving of 10%-60%, filters, and makes Chinese medicine composition extract; Extraction solvent is water, ethanol, alcohol-water mixed solution.
2. the application of the extract of a kind of Chinese medicine composition with antiallergic effect claimed in claim 1 in cosmetics, it is characterized in that the extract that contains Chinese medicine composition claimed in claim 1 in cosmetics, its consumption is 0.05-20%, and preferable amount is 1-10%.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922310A (en) * | 2015-05-21 | 2015-09-23 | 广东轻工职业技术学院 | Traditional Chinese medicine composition with bacteriostasis function and application of traditional Chinese medicine composition to daily necessities |
| CN105078825A (en) * | 2015-08-19 | 2015-11-25 | 范伟娇 | Traditional Chinese medicine mask for whitening skin and preparation method thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN111202779A (en) * | 2020-02-20 | 2020-05-29 | 东莞波顿香料有限公司 | Acne-removing composition and preparation method and application thereof |
| CN114886999A (en) * | 2022-05-31 | 2022-08-12 | 济生(上海)实业有限公司 | Traditional Chinese medicine extract composition with anti-allergy, tranquilizing and relieving effects and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380417A (en) * | 2008-10-20 | 2009-03-11 | 吴伶 | Preparation for quickly treating urticaria |
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2014
- 2014-02-26 CN CN201410065740.3A patent/CN103751530B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380417A (en) * | 2008-10-20 | 2009-03-11 | 吴伶 | Preparation for quickly treating urticaria |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922310A (en) * | 2015-05-21 | 2015-09-23 | 广东轻工职业技术学院 | Traditional Chinese medicine composition with bacteriostasis function and application of traditional Chinese medicine composition to daily necessities |
| CN105078825A (en) * | 2015-08-19 | 2015-11-25 | 范伟娇 | Traditional Chinese medicine mask for whitening skin and preparation method thereof |
| CN109758391A (en) * | 2018-12-06 | 2019-05-17 | 浙江大学自贡创新中心 | It is a kind of to have effects that the plant composition of antiallergic |
| CN111202779A (en) * | 2020-02-20 | 2020-05-29 | 东莞波顿香料有限公司 | Acne-removing composition and preparation method and application thereof |
| CN111202779B (en) * | 2020-02-20 | 2021-08-24 | 东莞波顿香料有限公司 | Acne-removing composition and preparation method and application thereof |
| CN114886999A (en) * | 2022-05-31 | 2022-08-12 | 济生(上海)实业有限公司 | Traditional Chinese medicine extract composition with anti-allergy, tranquilizing and relieving effects and preparation method and application thereof |
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Effective date of registration: 20160316 Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Applicant after: Guangdong Industry Technical College Applicant after: GUANGDONG GADETIN DAILY NECESSITIES CO., LTD. Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Applicant before: Guangdong Industry Technical College |
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