CN107137287A - A kind of anti-oxidant sleep mask - Google Patents

A kind of anti-oxidant sleep mask Download PDF

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Publication number
CN107137287A
CN107137287A CN201710450849.2A CN201710450849A CN107137287A CN 107137287 A CN107137287 A CN 107137287A CN 201710450849 A CN201710450849 A CN 201710450849A CN 107137287 A CN107137287 A CN 107137287A
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Prior art keywords
extract
oxidant
herb
stephanotis
root
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CN201710450849.2A
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Chinese (zh)
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不公告发明人
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Foshan Harvest Chemical Technology Co Ltd
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Foshan Harvest Chemical Technology Co Ltd
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Priority to CN201710450849.2A priority Critical patent/CN107137287A/en
Publication of CN107137287A publication Critical patent/CN107137287A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585Organosilicon compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of anti-oxidant sleep mask.Contain stephanotis extract, semi-pinnated brake herb extract and indian skullcap herb with root extract active component, wherein indian skullcap herb with root wogonoside can suppress the inflammatory reaction of bacteria lipopolysaccharide induction, stephanotis Bisbenzylisoquinolincompounds can further suppress inflammatory factor release simultaneously, the hazardous medium that can also suppress to be catalyzed due to inflammation relevant enzyme is produced, so as to realize excellent antiinflammatory action;In addition; indian skullcap herb with root wogonoside can protect cell, and because of Anoxia, over oxidation does not produce free radical; and remove part free radical; with reference to Semi-pinnated Brake Herb cyanidenon strong reducing property; intracellular unnecessary free radical can be reduced; plus the suppression oxidative stress effect of stephanotis extract, recover the activity for the superoxide dismutase and catalase being damaged, so as to reach significant anti-oxidation efficacy;Facial mask of the present invention can also repair damaged cell, enhance metabolism, and make skin more pale flexible.

Description

A kind of anti-oxidant sleep mask
Technical field
The present invention relates to cosmetic field, and in particular to a kind of anti-oxidant sleep mask.
Background technology
The anti-oxidant abbreviation for referring to resisting oxidation free radical.Human body with extraneous continuous contact, including breathing because (aoxidize anti- Should), outside contamination, radioactive ray irradiation etc. factor free radical is constantly produced in body.Anti-oxidant is exactly any with low dense There is the material for the oxidation reaction that just can effectively suppress free radical in degree, its mechanism of action can act directly on free radical, or It is the material for consuming easily generation free radical indirectly, prevents further reaction.Human body is being inevitably generated freedom While base, the polyphenoils of resisting free radical is also being produced naturally, is being attacked with offsetting oxidation of the free radical to human body cell Hit.Research has shown that, the antioxidant system of human body be one can it is comparable with immune system, with improving and sophisticated functions is System, the oxidation resistant ability of body is stronger, and more healthy, life is also longer.Anti-oxidant increasing research display is pre- health care Old important step, because cell and tissue breakdown can be influenceed metabolic function, and can cause different by free radical or oxidant Health problem.If excessive oxyradical can be eliminated, for caused by many free radicals and aging-related disease can Enough preventions.Such as common cancer, artery sclerosis, diabetes, cataract, cardiovascular disease, senile dementia, arthritis, these Disease is considered to related to free radical.Research is anti-oxidant can effectively to overcome the harm that it is brought, so anti-oxidant protected Strong product, Management of Cosmetics Enterprises is classified as one of main R&D direction, is also one of most important feature demand in market.
Existing anti-oxidant face mask is present realizes that temporary transient whitening anti-wrinkling is acted on using heavy metal, not only can not effectively protect Skin, irreversible injury is will also result in skin.Be the preferably period that skin is repaired in the evening, and good sleep mask can be assisted Skin is helped to be repaired, not only effect is poor for poor facial mask, can also injure human body, so people propose to the security of sleep mask Higher requirement.
The content of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of anti-oxidant sleep mask.Skin repair can be effectively facilitated, is had There is significant antioxidation.
To reach above-mentioned purpose, the present invention provides following technical scheme:
A kind of anti-oxidant sleep mask is made up of the raw material of following parts by weight:0.8-3 parts of stephanotis extract, Semi-pinnated Brake Herb are carried Take 1-3 parts of thing, 0.2--2 parts of indian skullcap herb with root extract, 5-15 parts of butanediol, 2-10 parts of glycerine, 0.1-0.4 parts of tocopherol, hyalomitome Sour 0.03-0.1 parts, 1-8 parts of glycine betaine, 2-7 parts of dimethyl silicone polymer, 2-6 parts of ring five dimethyl silicone polymer, Phenoxyethanol 0.1-0.8 parts, deionized water is to 100 parts.
Preferably, the facial mask is made up of the raw material of following parts by weight:2 parts of stephanotis extract, semi-pinnated brake herb extract 2 Part, 1 part of indian skullcap herb with root extract, 10 parts of butanediol, 6 parts of glycerine, 0.3 part of tocopherol, 0.05 part of Sodium Hyaluronate, 5 parts of glycine betaine, 6 parts of dimethyl silicone polymer, 5 parts of ring five dimethyl silicone polymer, 0.5 part of Phenoxyethanol, deionized water are to 100 parts.
The preparation method of the stephanotis extract is:Stephanotis is cleaned into drying, 40-60 mesh sieves were crushed, by feed liquid Than 1:(20-30) adds 50-70% ethanol, and refluxing extraction 2 times under the conditions of 70-90 DEG C, each 15-45min is filtered, merged Filtrate rotated concentration again.
The preparation method of the semi-pinnated brake herb extract is:By Semi-pinnated Brake Herb drying and crushing, coarse powder is taken by solid-liquid ratio 1:(50-60) Distilled water is added, 2-4min is pre-processed under microwave power 800W, then the refluxing extraction 1-2h at 80-100 DEG C, is filtered, filter Liquid is through drying.
The preparation method of the indian skullcap herb with root extract is:Indian skullcap herb with root is cleaned into drying, 60-80 mesh sieves were crushed, by feed liquid Than 1:(10-20) is added after ethyl acetate, immersion 12h, and normal temperature ultrasound 30-50min is centrifuged under 4000-6000r/min, taken The rotated evaporation of supernatant removes ethyl acetate.
The present invention also provides a kind of preparation method of anti-oxidant sleep mask, comprises the following steps:(1) by butanediol, sweet Oil, tocopherol, Sodium Hyaluronate, glycine betaine, dimethyl silicone polymer, ring five dimethyl silicone polymer, deionized water mixing are stirred Mix and be heated to 70-80 DEG C, be allowed to dissolving well mixed;
(2) 40-50 DEG C to be cooled to, stephanotis extract, semi-pinnated brake herb extract, indian skullcap herb with root extract, benzene oxygen second are added Alcohol, cooling discharging after stirring.
Following introduce is made to the plant extracts of the present invention:
Stephanotis is the dried root of Menispermaceae Stephania Radix Stephaniae Cepharanthae, and its extract main component is alkaloid, Wherein bisbenzylisoquinoline alkaloid content is most.Primary pharmacological activity is anti-inflammation, antalgic and sedative, adjustment is immunized, resists Oxidation.Its anti-inflammatory is embodied in the generation and release of the superoxide ion and inflammatory factor that can suppress in human body cell, suppresses scorching Hazardous medium in disease is produced;In addition, it, which has, loosens calmness, promote the effect of sleep, anxiety can be alleviated;Suppress oxidative stress Effect, removes free radical, realizes antioxidation, so as to protect cell, improves tissue metabolism.
Semi-pinnated Brake Herb, also known as half of fern, Chinese lobelia, unilateral flag, are Pteridaceae plant, are the conventional medium-height grass of south China Medicine.Its extract contains many kinds of substance composition such as volatile oil, terpene, flavones, saponin(e.Wherein main matter is Flavonoid substances, Include apiolin and cyanidenon and its derivative etc..The antioxidation of cyanidenon is mainly manifested in own as also Oxidation reaction occurs for former agent, strengthens the activity of organism antioxidant system, and its reason is that the material contains 2 hydroxyls, one carbonyl Also carbon-carbon double bond, embodies strong reducing property, can be used as hydrogen donor, it is easy to which providing for out hydrogen atom is used to reduce freedom Base.In addition, cyanidenon can also strengthen the activity of intracellular antioxidase, impaired superoxide dismutase and peroxide can be recovered Change the activity of hydrogen enzyme, while improving VA, VC, VE storage capacity, improve oxidative damage, moreover it is possible to strengthen glutathione peroxidase With glutathione reductase activity, strengthen the content of glutathione and then improve oxidation resistance.
Indian skullcap herb with root is lamiaceae labiatae scutellaria draft plant for many years, is distributed widely in China, South Korea, Japan and Southeast Asia state Family.Main active is flavone compound, such as apiolin, wogonin and wogonoside in indian skullcap herb with root extract.Its Middle wogonoside has antiinflammatory action, can suppress the inflammatory reaction that lipopolysaccharide-induced cell is produced, can also suppress inflammatory mediator with The release of proinflammatory factor, while can suppress to produce the expression of the relevant enzyme of inflammation, and then suppresses the generation of inflammation.Because the Chinese is yellow A kind of reed mentioned in ancient books glycosides effectively can remove free radical while can also be played a protective role to the cell of Anoxia, so with oxidation-resisting and caducity Defencive function.
Compared with prior art, the device have the advantages that as follows:(1) this product is a kind of sleep mask, is contained Stephanotis extract, semi-pinnated brake herb extract and indian skullcap herb with root extract active component, wherein indian skullcap herb with root wogonoside can suppress bacterium The inflammatory reaction of induced by LPS, while stephanotis Bisbenzylisoquinolincompounds can further suppress inflammatory factor release, moreover it is possible to suppress The hazardous medium being catalyzed due to inflammation relevant enzyme is produced, so as to realize excellent antiinflammatory action;(2) in addition, the indian skullcap herb with root Chinese is yellow A kind of reed mentioned in ancient books glycosides can protect cell, and because of Anoxia, over oxidation does not produce free radical, and removes part free radical, with reference to Semi-pinnated Brake Herb Cyanidenon strong reducing property, can reduce intracellular unnecessary free radical, add the suppression oxidative stress effect of stephanotis extract, extensive The superoxide dismutase and the activity of catalase being damaged again, so as to reach significant anti-oxidation efficacy;(3) it is of the invention Facial mask can repair the cell impaired because of oxidation, enhance metabolism, and make skin more pale flexible;(4) it is of the invention to sleep Dormancy facial mask does not only have significant skin care effect, also with facial microcirculation is improved, loosens skin of releiving, and then promote the work of sleep With;(5) sleep mask of the invention is safe, and no added harmful material more has no side effect.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.The anti-oxidant sleep mask of the invention of embodiment 1~5 Formula is shown in Table one
Table one
The preparation method of stephanotis extract is described in embodiment 1~5:Stephanotis is cleaned into drying, 60 mesh were crushed Sieve, by solid-liquid ratio 1:30 add 70% ethanol, and refluxing extraction 2 times under the conditions of 90 DEG C, each 45min is filtered, merging filtrate is again Rotated concentration.
The preparation method of semi-pinnated brake herb extract is described in embodiment 1~5:By Semi-pinnated Brake Herb drying and crushing, coarse powder is taken by material Liquor ratio 1:60 add distilled water, 4min are pre-processed under microwave power 800W, then the refluxing extraction 2h at 800 DEG C, filter, filter Liquid is through drying.
The preparation method of indian skullcap herb with root extract is described in embodiment 1~5:Indian skullcap herb with root is cleaned into drying, 80 mesh were crushed Sieve, by solid-liquid ratio 1:20 add after ethyl acetate, immersion 12h, and normal temperature ultrasound 50min centrifuges under 6000r/min, takes supernatant The rotated evaporation of liquid removes ethyl acetate.
The preparation method of anti-oxidant sleep mask described in embodiment 1~5, comprise the following steps:
(1) by butanediol, glycerine, tocopherol, Sodium Hyaluronate, glycine betaine, dimethyl silicone polymer, the poly dimethyl of ring five Siloxanes, deionized water mix and are heated to 70 DEG C, are allowed to dissolving well mixed;
(2) wait to be cooled to 40 DEG C, add stephanotis extract, semi-pinnated brake herb extract, indian skullcap herb with root extract, Phenoxyethanol, Cooling discharging after stirring.
Comparative example 1
Difference with embodiment 1 is not add stephanotis extract, and other preparation conditions and method are same as Example 1.
Comparative example 2
Difference with embodiment 1 is not add semi-pinnated brake herb extract, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 1 is not add indian skullcap herb with root extract, and other preparation conditions and method are same as Example 1.
Comparative example 4
Difference with embodiment 1 is not add stephanotis extract, semi-pinnated brake herb extract, indian skullcap herb with root extract, other systems Standby condition and method are same as Example 1.
Sleep efficacy validation
The clinical observation of the present invention is as follows:
This experiment uses volunteer women (general person with sleep disorders) 120.Standard sleep is lacked of proper care, including:Amount of sleep It is not enough;Poor sleeping quality;Sleep enough time is still felt to be unable to dispelling fatigue;Night awakens number of times more than 2 times or morning early awakening; Many nightmares etc..Embodiment 1, comparative example 1~4, and commercially available example is used (to claim on the market with the anti-oxidant of good effects every night Sleep mask) once, altogether using one month/15 days.
Effective evaluation standard is effective:It is easy to fall asleep, and amount of sleep can reach that sleep quality is good 7 hours, and sleep is deep, night Number of times of awakening is less than 1 time, also can easily be fallen asleep after awakening even if night, and next day feels that the state of mind is good;Take a turn for the better:It can fall asleep, Amount of sleep can reach that preferably, night awakening number of times is less than 1 time sleep quality, is occasionally had and is difficult what is fallen asleep after night awakening 7 hours Situation, next day feels that the state of mind is good;It is invalid:Symptom is without improvement.Experiment was met such as following table two:
Table two
Formula that the description of test present invention is used obtains hypnotic effect and is far superior to commercially available product and embodiment, embodiment 1 with Comparative example 1~3, which compares, understands each plant component Synergistic of the invention, and embodiment 1 is compared with comparative example 4 understands that the present invention is main Active ingredient is plant composition.
Efficacy validation
Atraumatic human body evaluation is carried out to the anti-oxidant sleep mask prepared by embodiment 1~5, while with a commercially available Lay claim to good anti-oxidant sleep mask facial mask as a control group.
Test object:Each experimental group is 20 women (35-50 Sui);Use:Once a night, persistently using 4 weeks;Test Project:The soft degree of skin, wrinkle depth (crows feet area), skin elasticity.Result on trial refers to table three.
Table three
Antioxidative Activity Determination
Compound concentration is 1 × 10-4mol/L DPPH ethanol solutions.By embodiment 1~5 and comparative example 1~4 and Commercially available product (claiming the facial mask with good antioxidant effect on the market) be configured to 80% ethanol concentration be respectively 0.01, 0.04th, 0.08,0.10,0.12,0.16,0.20,0.24,0.26 testing sample solution.Take respectively 5mL sample solutions and DPPH solution, and be well mixed, avoid light place 30min, returned to zero with 80% ethanol, absorbance A i is determined at 517BITI;Together Quadrat method, takes 5mL80% alcohol solvents to be mutually mixed uniformly with sample solution, absorbance is determined after avoid light place 30min respectively Aj;5mL80% alcohol solvents add 5mLDPPH solution to mix, avoid light place 30min, determine absorbance A c.Finally according to following Formula calculates free radical scavenging activity:
IP%=[1 one (Ai-Aj)/Ac] × 100
Ai is the absorption values after sample is acted on DPPH in formula;
Aj is contribution of the sample itself to absorbance;Ac is DPPH itself absorption.
Four are shown in Table to the ability measurement result that embodiment 1~5 and comparative example 1~4 and commercially available product remove DPPH:
Table four
The present invention is described by way of example above, but the invention is not restricted to above-mentioned specific embodiment, it is all to be based on Any change or modification that the present invention is done belong to the scope of protection of present invention.

Claims (6)

1. a kind of anti-oxidant sleep mask, it is characterised in that the facial mask is made up of the raw material of following parts by weight:
2. a kind of anti-oxidant sleep mask according to claim 1, it is characterised in that the facial mask is by following parts by weight Raw material is constituted:
3. a kind of anti-oxidant sleep mask according to claim 1 or 2, it is characterised in that the stephanotis extract Preparation method is:Stephanotis is cleaned into drying, 40-60 mesh sieves were crushed, by solid-liquid ratio 1:(20-30) adds 50-70% ethanol, Refluxing extraction 2 times under the conditions of 70-90 DEG C, each 15-45min, filtering, merging filtrate rotated concentration again.
4. a kind of anti-oxidant sleep mask according to claim 1 or 2, it is characterised in that the semi-pinnated brake herb extract Preparation method is:By Semi-pinnated Brake Herb drying and crushing, coarse powder is taken by solid-liquid ratio 1:(50-60) adds distilled water, in microwave power 800W Lower pretreatment 2-4min, the then refluxing extraction 1-2h at 80-100 DEG C, filtering, filtrate is through drying.
5. a kind of anti-oxidant sleep mask according to claim 1 or 2, it is characterised in that the indian skullcap herb with root extract Preparation method is:Indian skullcap herb with root is cleaned into drying, 60-80 mesh sieves were crushed, by solid-liquid ratio 1:(10-20) adds ethyl acetate, leaching Steep after 12h, normal temperature ultrasound 30-50min, centrifuged under 4000-6000r/min, take the rotated evaporation of supernatant to remove acetic acid second Ester.
6. a kind of preparation method of the anti-oxidant sleep mask as described in claim any one of 1-5, it is characterised in that including following Step:
(1) by butanediol, glycerine, tocopherol, Sodium Hyaluronate, glycine betaine, dimethyl silicone polymer, the polydimethylsiloxanes of ring five Alkane, deionized water mix and are heated to 70-80 DEG C, are allowed to dissolving well mixed;
(2) 40-50 DEG C to be cooled to, stephanotis extract, semi-pinnated brake herb extract, indian skullcap herb with root extract, Phenoxyethanol is added, is stirred Mix uniform rear cooling discharging.
CN201710450849.2A 2017-06-14 2017-06-14 A kind of anti-oxidant sleep mask Withdrawn CN107137287A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108619023A (en) * 2018-06-21 2018-10-09 佛山市三水区嘉信农业技术研究院(普通合伙) A kind of pseudo-ginseng anti-oxidant face mask and preparation method thereof
CN110051571A (en) * 2018-09-18 2019-07-26 广州青岚生物科技有限公司 A kind of pharmaceutical composition of sun-proof reparation
CN114869818A (en) * 2022-05-13 2022-08-09 妙梵医药科技(广州)有限公司 Composition with repairing effect and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108619023A (en) * 2018-06-21 2018-10-09 佛山市三水区嘉信农业技术研究院(普通合伙) A kind of pseudo-ginseng anti-oxidant face mask and preparation method thereof
CN110051571A (en) * 2018-09-18 2019-07-26 广州青岚生物科技有限公司 A kind of pharmaceutical composition of sun-proof reparation
CN114869818A (en) * 2022-05-13 2022-08-09 妙梵医药科技(广州)有限公司 Composition with repairing effect and preparation method thereof

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Application publication date: 20170908