CN106420536A - Hydrated cream and preparation method thereof - Google Patents
Hydrated cream and preparation method thereof Download PDFInfo
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- CN106420536A CN106420536A CN201611056664.5A CN201611056664A CN106420536A CN 106420536 A CN106420536 A CN 106420536A CN 201611056664 A CN201611056664 A CN 201611056664A CN 106420536 A CN106420536 A CN 106420536A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The invention discloses hydrated cream and a preparation method thereof. The hydrated cream is prepared from the following raw materials in parts by weight: 45-90 parts of water, 3-10 parts of propanediol, 0.1-1.0 part of carbomer, 0.1-0.2 part of methyl hydroxybenzoate, 0.02-0.1 part of sodium hyaluronate, 3-10 parts of glycerol, 0.1-0.3 part of allantoin, 0.1-0.3 part of EDTA disodium, 0.1-0.5 part of imidazolidinyl urea, 1.0-3.0 parts of betaine, 0.5-3.0 parts of an emulsifier, 0.2-2.0 parts of ceteayl alcohol, 3.0-6.0 parts of octyl poly(dimethylsiloxane), 1.0-5.0 parts of poly(dimethylsiloxane), 0.8-2.0 parts of a thickening and solubilizing component, 1.0-3.0 parts of a seaweed extract, 1.0-3.0 parts of nicotinamide, 1.0-5.0 parts of a dendrobium officinale kimura ex migo extract and 0.01-0.06 part of essence. The hydrated cream has the effects of calming, soothing skin and diminishing inflammation.
Description
Technical field
The present invention relates to a kind of cosmetics of everyday use technical field, more particularly to a kind of blushing and preparation method thereof.
Background technology
It is generally acknowledged that sensitive skin is the skin condition that a kind of height is not tolerated, with the continuous development of modern society,
Cosmetics, chemicals using be continuously increased, increasing environmental pollution and irregular, diet of working and resting are uncoordinated etc. all
It is possible to cause skin allergy.Due to a variety of causes so that the crowd of sensitive skin is also continuously increased.It is reported that, Europe is beautiful
The women of state and Japan about 40%-50% is sensitivity skin, and in China, a research of L'Oreal shows, about 36.1%
Women be sensitive skin.
Sensitive skin be vulnerable to the stimulation of various factors and produce twinge, burn, the subjective symptom such as tight, prurituss, skin
Skin outward appearance there is also the symptoms such as red and swollen, long pox, inflammation normally or with slight desquamation, erythema and drying when serious, impact
Skin health, brings the sense of discomfort of skin.It is thus desirable to providing a kind of skin care item of suitable sensitive skin crowd.
The Chinese patent that Authorization Notice No. is CN103784368A, authorized announcement date is on 05 14th, 2014 discloses one
Kind there are the skin care compositionss of white-skinned face function of releiving, skin care compositionss add Chinese medicine extract in including, Chinese medicine extract by
The crude drug of following weight is made：Herba Hedyotidis Diffusae 10-30, Cortex Lycii 10-30, Radix et Caulis Opuntiae Dillenii 10-20, Radix Sophorae Flavescentiss 10-20,
Folium Ginkgo 10-20, Radix Glycyrrhizae 10-20, Radix Et Rhizoma Fagopyri Tatarici 10-20.
Content of the invention
It is an object of the invention to provide a kind of blushing, with calmness, antiinflammatory, the effect that releives.
The above-mentioned technical purpose of the present invention technical scheme is that：
A kind of blushing, is characterized in that, the raw material comprising following weight portion：
Water：45-90 part；
Propylene Glycol：3-10 part；
Carbomer：0.1-1.0 part；
Methyl hydroxybenzoate：0.1-0.2 part；
Hyaluronate sodium：0.02-0.1 part；
Glycerol：3-10 part；
Allantoin：0.1-0.3 part；
EDETATE SODIUM：0.1-0.3 part；
Imidazolidinyl urea：0.1-0.5 part；
Glycine betaine：1.0-3.0 part；
Emulsifying agent：0.5-3.0 part；
Cetearyl alcohol：0.2-2.0 part；
Octyl group polydimethylsiloxane：3.0-6.0 part；
Polydimethylsiloxane：1.0-5.0 part；
Thickening solubility enhancing component：0.8-2.0 part；
Sargassum extract：1.0-3.0 part；
Nicotiamide：1.0-3.0 part；
Herba Dendrobii extract：1.0-5.0 part；
Essence：0.01-0.06 part.
Water, Propylene Glycol constitute dicyandiamide solution, both complete miscibilities, Propylene Glycol belongs to polyhydric alcohol, the hydroxyl for including thereon with
Water forms hydrogen bond so as to capture hydrone, have functions that water lock moisturizing, and does not have greasy feeling so that blushing is overall salubrious
Non-greasy.Propylene Glycol is also acted on auxiliary anticorrosion.
Carbomer and glycine betaine collectively form the thickening agent of blushing and viscosity control agent, for adjusting blushing entirety
Viscosity.Carbomer is hydrophilic thickening agent, with good transparency so that product is seen salubrious with water profit on the whole
Visual effect.And glycine betaine is highly soluble in water in addition to the effect for controlling with viscosity, moisturizing therefore can also be aided in.
Methyl hydroxybenzoate is used as antibacterial, for suppressing the growth of antibacterial in blushing, so as to keep effect of product.
Skin sensitivity is relevant with dry skin, and hyaluronate sodium is the potent wetting agent of macromolecule, can absorb itself weight
1000 times of moisture so that blushing has good performance of keeping humidity, reduce the allergic phenomenas such as scaly dry skin, decortication.Glycerol is little
Molecule wetting agent, together with hyaluronate sodium, collectively forms the efficient moisture-retention composition of blushing.
Emulsifying agent and cetearyl alcohol collectively constitute surface active agent composition, for improve in emulsion water phase and oil phase it
Between surface tension, be allowed between water phase and the component of oil phase, form uniform and stable emulsion, reduce skin care item water oil layer
The appearance of phenomenon.
It isostearyl glyceryl pentaerythrityl ether, is that blushing provides lubricious texture that octyl group polydimethylsiloxane and polydimethylsiloxane are, changes
The docile degree of kind blushing and skin.
Thickening solubility enhancing component equally has the effect for adjusting viscosity, while also having agglomeration resistance and improving junction performance
Effect, mainly offer effect during raw material hybrid process.
Allantoin is a kind of amphoteric compound, with good associativity and phase between blushing moderate rain volume other components
Capacitive, extracts from Radix Arnebiae (Radix Lithospermi) and forms, with antiinflammatory, the function of releiving and help skin tissue's regeneration.Nicotiamide nicotiamide has
Certain anti-inflammatory efficacy, a result of study of the state University Medical College in USA New York shows, uses the nicotiamide ointment containing 4% and contains
1% external clindamycin ointment carries out control experiment, as a result shows that nicotiamide is changing to acne after treatment in 8 weeks
The effect of the aspects such as the kind, minimizing of inflammation focus number exceedes clindamycin 20%.
Sargassum extract, Sargassum has the activity of antibacterium and funguses, because which contains multiple antibiotic property compositions, such as terpenoid,
Aliphatic compound, bromine phenol, hydroquinone, phloroglucinol, alicyclic ring (or sulfur heterocyclic ring) compound and polysaccharide etc..Wherein terpenoid
There is inhibitory activity to multiple bacterium such as staphylococcuses, mycobacterium and bacillus megaterium, have moderate inhibitory activity, bromine phenol to funguses
Compound and aliphatic compound have antibacterial activity polysaccharide to trichophyton gypseum, Gypsum Fibrosum to gram positive bacteria and negative bacterium etc.
The dermatophytess such as sample sporidiole bacteria, acrothesium floccosum and Candida albicans have certain bacteriostatic activity.Therefore blushing has
The effects such as having anti-inflammation, prevent skin infection and allergic dermatitises.Additionally, the sulfur for wherein containing, the work(with antiinflammatory calmness
Effect；Contained abundant iodine also has antibacterial disinfective action.Herba Dendrobii extract, have functions that antibacterial, antiinflammatory.Both of which
Be with natural extract the effect of antiinflammatory.While the effects such as Sargassum extract also has moisturizing, defying age.Herba Dendrobii
In main component Herba Dendrobii active polysaccharide, be a kind of Natural antioxidant and immunostimulant, remove free radical, antioxidation,
Anti-ageing aspect of waiting for a long time has remarkable efficacy.
EDETATE SODIUM and imidazolidinyl urea collectively constitute the preservative of blushing, for slowing down the life of microorganism in blushing
The destruction to above-mentioned natural extract that length is bred and caused.
More preferably：Emulsifying agent is at least in cetearyl alcohol Fructus Canarii albi oleate and the smooth Fructus Canarii albi oleate of Pyrusussuriensiss
Kind.
More preferably：Thickening solubility enhancing component includes thickening agent and solubilizing agent, and thickening agent is sodium acrylate and acryloyl
One kind in dimethyltaurine sodium copolymer, solubilizing agent is at least one in 2-Methylpentadecane and Polyoxyethylene Sorbitan Monooleate.
More preferably：A kind of blushing also includes bean milk tunning filtrate, and its parts by weight is 0.6-3.0.
The main active of bean milk tunning filtrate is lactobacilluss, and lactobacilluss have the activity of anti-inflammatory, energy
The skin damage that enough suppression flavacin brings, improves the antiinflammatory effect of releiving of blushing, and bean milk tunning further
Raw material is easy to get, and it is convenient to prepare.
More preferably：A kind of blushing also includes licorice, and its parts by weight is 0.1-0.3.
Licorice is boiled extraction and obtained by licorice, and its main component is glycyrrhizin, with antiinflammatory, auxiliary whitening and town
Quiet effect that releives, reduces the discomfort that inflammation is brought for skin.
More preferably：A kind of blushing also includes procyanidin, and its parts by weight is 0.1-3.0.
Procyanidin main source is Fructus Vitis viniferae, Cortex Pini, belongs to one kind of flavonoid, with efficient antioxidation, grinds
It is ascorbic 20 times to study carefully its oxidation resistance of display, is 50 times of vitamin E, delaying skin aging.
More preferably：Herba Dendrobii extract is extracted in accordance with the following steps and is obtained：
A, the Herba Dendrobii for air-drying is ground into 80 mesh powder, adds in reaction vessel, by Herba Dendrobii and water 1:10 (quality：
Volume) ratio soak 1h；
B, 85 DEG C are heated to, reflux extraction extracts 2h, filter, collect filtrate；
C, add water in reaction vessel again, by Herba Dendrobii and water 1:8 (quality：Volume) ratio add water, be heated to 75 DEG C
Reflux, extract, 4h, filters afterwards, collects filtrate；
D, merging filtrate twice, spray drying is carried out after concentrating under reduced pressure and obtains Herba Dendrobii extract.
The extracting method is simple to operate, and by extracting twice, is conducive to fully extracting the effective ingredient in raw material
Out, increase operation rate.
Second goal of the invention of the present invention is to provide a kind of preparation method of blushing, and the method is according to the spy of different material
The sectional temperature-controlled activity for being dividedly in some parts raw material, being conducive to preferably keeping various natural extracts of property.
A kind of preparation method of blushing, comprises the steps：
S1, the A1 water of formula ratio is heated to 85 DEG C in water phase pot, the A2 oil phase of formula ratio is heated to 85 in oil phase pot
DEG C, 20min is incubated, is stirred；
S2, A1 water phase and A2 oil phase are mixed, homogenizing 3min, are cooled to after 75 DEG C and the B phase homogenizing stirring 3min of formula ratio is added,
15min is incubated again；
S3,60 DEG C are cooled to, the C phase of formula ratio are added, is stirred；
S4,45 DEG C are cooled to, the D phase of formula ratio are added, is stirred；
S5,38 DEG C are cooled to, 200 mesh are filtered, and taken the dish out of the pot, check, are packed；
Wherein：Described A1 water mutually includes the following raw material：Water, Propylene Glycol, Carbomer, methyl hydroxybenzoate, hyaluronate sodium, glycerol,
Licorice, allantoin, EDETATE SODIUM, imidazolidinyl urea and glycine betaine；A2 oil phase includes the following raw material：Emulsifying agent, cetearyl alcohol
Alcohol, octyl group polydimethylsiloxane and polydimethylsiloxane；B phase is：Thickening solubility enhancing component；C phase is：Sargassum extract；D phase
Including the following raw material：Bean milk tunning filtrate, nicotiamide, essence, procyanidin, Herba Dendrobii extract.
Using above-mentioned technique, raw material is dividedly in some parts according to the characteristic of different material is sectional temperature-controlled, is conducive to preferably keeping
The activity of various natural extracts.
In sum, the invention has the advantages that：1st, according to result of the test, the blushing property of the present invention
Gently, its skin acute irritation test result is nonirritant；2nd, the blushing of the present invention in sensitivity crowd almost without
Sensitization, is very suitable for sensitive skin crowd use；3rd, blushing prepared by the present invention has to scytitiss and alleviates well
Effect, the effect of releiving with calm antiinflammatory.
Specific embodiment
Hereinafter the present invention is described in further detail.
This specific embodiment is only explanation of the invention, and which is not limitation of the present invention, people in the art
Member can make the modification without creative contribution after this specification is read as needed to the present embodiment, but as long as at this
All protected by Patent Law in the protection domain of invention.
Embodiment 1-7：
A kind of blushing, is obtained using following technique：
S1, the A1 water of formula ratio is heated to 85 DEG C in water phase pot, the A2 oil phase of formula ratio is heated to 85 in oil phase pot
DEG C, stir under the conditions of 500-600rpm, while stirring, be incubated 20min；
S2, A1 water phase and A2 oil phase are mixed, homogenizing 3min, be cooled to after 75 DEG C and the B phase of formula ratio is added, with 400-500rpm
Rotating speed homogenizing stirring 3min, then be incubated 15min；
S3, be cooled to 60 DEG C, add the C phase of formula ratio, stirred with the rotating speed of 400-500rpm, mixing time be
10min；
S4, be cooled to 45 DEG C, add the D phase of formula ratio, stirred with the rotating speed of 400-500rpm, mixing time be
15min；
S5,38 DEG C are cooled to, 200 mesh are filtered, and taken the dish out of the pot, check, are packed；
Wherein：According to the difference of embodiment, A1 water mutually includes all or part of the following raw material：Water, Propylene Glycol, Carbomer, hydroxyl
Benzene methyl, hyaluronate sodium, glycerol, licorice, allantoin, EDETATE SODIUM, imidazolidinyl urea and glycine betaine；A2 oil phase include as
Lower raw material：Emulsifying agent, cetearyl alcohol, octyl group polydimethylsiloxane and polydimethylsiloxane；B phase is：Thickening solubilising group
Point；C phase is：Sargassum extract；D phase includes all or part of the following raw material：Bean milk tunning filtrate, nicotiamide, essence,
Procyanidin, Herba Dendrobii extract.
Herba Dendrobii extract in embodiment 1-7 is extracted in accordance with the following steps and is obtained：
A, the Herba Dendrobii for air-drying is ground into 80 mesh powder, adds in reaction vessel, by Herba Dendrobii and water 1:10 (quality：
Volume) ratio soak 1h；
B, 85 DEG C are heated to, reflux extraction extracts 2h, filter, collect filtrate；
C, add water in reaction vessel again, by Herba Dendrobii and water 1:8 (quality：Volume) ratio add water, be heated to 75 DEG C
Reflux, extract, 4h, filters afterwards, collects filtrate；
D, merge filtrate twice, 0.8g/mL is evaporated to, is spray-dried and obtains Herba Dendrobii extract.
Embodiment 8：It is with the difference of embodiment 4, Herba Dendrobii extract used is Shaanxi domain life in three former days
The brownish-yellow powder shape Herba Dendrobii extract that Tetramune company limited buys.
Comparative example 1：Using documents, (it is 05 month 2014 that Authorization Notice No. is CN103784368A, authorized announcement date
14 days) in the frost of releiving for preparing of the formula of embodiment 1 and technique.
Comparative example 2-3：The commercially available no antiinflammatory that selects immediately is releived the moisturizing face cream of effect.
Comparative example 4：The commercially available antiinflammatory comprising Herba Lysimachiae foenum-graeci extract of random choose is releived moisturizing face cream.
The component of embodiment 1-7 and its parts by weight are as shown in table 1.
The component of 1 embodiment 1-7 of table and its parts by weight
Test one：Irritation test
(1) test specimen：Respectively with the blushing of embodiment 1-8 preparation as test sample is treated, comparative example 1-4 is to be contrasted with reference to sample
Test；
(2) content of the test：Reference《Cosmetics health specification (2007) version》Regulation is tested, all parallel choosings of each test specimen
Select 10 healthy albino guinea-pigs to be tested, test humiture is 20-25 DEG C/60-70RH%；About 24hr before test, will test
Back part of animal spinal column both sides are cut by hair, and it is 2.5cm × 2.5cm that unhairing scope is respectively 3cm × 3cm, application area；Take tested material
0.5g is coated directly on skin, is covered with oilpaper and two-layer gauze, then fixed with nonirritant adhesive plaster, application after smearing
24h.Residual tested material is removed with warm water after off-test.After tested material is removed, area skin is smeared in 1,24,48 and 72h observations
Reaction, carries out dermoreaction scoring by table 2, carries out overall merit with the meansigma methodss of animal subject integration, little according to 24,48 and 72
When each observation time point top average, judge skin irritation intensity by table 3.Oilpaper and two-layer gauze are covered, then with stingless
The processing method fixed by sharp property adhesive plaster is used as control.
2 skin wound repair of table scoring reference standard
3 skin irritation strength grading reference standard of table
| Integral mean value x | Strength grading |
| 0<x≦0.5 | Nonirritant |
| 0.5<x≦2.0 | Slight stimulation |
| 2.0<x≦6.0 | Medium zest |
| 6.0<x≦8.0 | Strong and stimulating |
Result of the test is as shown in table 4, and table 4 shows, the properties of samples of embodiment 1-8 is gentle, its skin acute irritation test
As a result it is nonirritant.
4 acute skin irritation test result of table
Test two：Human body sensitization test
(1) test crowd selection：Same living area is selected, life habit is close, 25-30 year close sensitivity of skin
Skin adult female experimenter 240, its initial skin state is no allergic symptom, is randomly divided into 12 groups, per organizing 20 people.
(2) content of the test：The test object of each sample is one group of 20 people；Experimenter washes away face in the conventional cleansing milk of morning and evening daily
After upper foul, by 0.5g tested material uniform application on face skin, any other chemical product is not used during testing.Respectively
In 0 day, 7 days, 30 days and 90 days, the skin conditions of experimenter are observed.Skin situation of change is referring to table 5.No significant change
No twinge is referred to, burnt, tight, prurituss, desquamation, erythema, red blood streak and occur situations such as dry；Slight allergy refers to occur gently
Situations such as spending desquamation, tight, red blood streak and dry；Moderate and above allergy refer to more serious sensation of pricking, burning sensation, scabies occur
Itch, small pox or erythema.Other skins such as moist degree of skin are not in range of observation.There are moderate and above anaphylaxis
The experimenter of shape no longer carries out follow-up test, number when therefore no significant change and slight allergy hurdle are test in form,
Moderate and above allergy number are accumulated number.
5 human body sensitization test result of table
Can be seen that in the tested crowd of whole 160 sensitivity skin in the present invention by human body sensitization test result,
Only 1 people occurs moderate and above allergic symptom in test after 90 days, and totally 8 people occur slight allergic symptom in test after 90 days, and two
Person's summation only accounts for the 5.6% of tested total number of persons, and ratio is less than commercially available skin care item of releiving (25%), far below commercially available common shield
Skin product (85% and 40%).Above result of the test shows, the blushing of the present invention almost without sensitization in sensitivity crowd, ten
Divide and be suitable for the crowd's use of sensitivity skin.
Test three：Skin antiinflammatory is releived effect test：
(1) test crowd selection：Same living area is selected, 25-30 year close sensitivity skin adult female of life habit
Experimenter 200, its initial skin state has been moderate inflammation, and degree of inflammation is close, is randomly divided into 12 groups, per group 20
People.
(2) content of the test：Content of the test：The test object of each sample is one group of 20 people；Experimenter is washed sooner or later conventional daily
After face milk washes away foul on the face, by 0.5g tested material uniform application on face skin, during testing, any other is not used
Chemical product.Respectively at 0 day, 7 days, 30 days and 90 days, the skin conditions of experimenter are observed.Skin situation of change is referring to table 6.
The experimenter for moderate and above allergic symptom occur no longer carries out follow-up test, and therefore in form, no significant change and inflammation are alleviated
Hurdle is number during test, and increased inflammation number is accumulated number.
6 skin antiinflammatory of table is releived effect test result
Releived effect test from skin antiinflammatory, in all 160 experimenters for employing embodiment of the present invention product
In, after 90 days, only there is the situation of increased inflammation in 2 people, have 96 people to occur in that the situation that inflammation is alleviated, account for total experimenter's
60%.Show that blushing prepared by the present invention has good mitigation to inflammation, the effect of releiving with calm antiinflammatory.And
And employ in all 160 experimenters of embodiment of the present invention product, have 133 people to occur that skin is calmer, releive, water profit,
Elastic, glossy etc., the 83.1% of tested total number of persons is accounted for, shows to releive in addition to antiinflammatory except calmness, the blushing of the present invention also has
There are the skin-protecting functions such as good moisturizing, it is adaptable to sensitivity skin crowd.
Summary result of the test understands, in all embodiments, the blushing for preparing according to the formula of embodiment 4 has most
Good antiallergic, antiinflammatory, calmness, the effect of releive.
Claims (8)
1. a kind of blushing, is characterized in that, the raw material comprising following weight portion：
Water：45-90 part；
Propylene Glycol：3-10 part；
Carbomer：0.1-1.0 part；
Methyl hydroxybenzoate：0.1-0.2 part；
Hyaluronate sodium：0.02-0.1 part；
Glycerol：3-10 part；
Allantoin：0.1-0.3 part；
EDETATE SODIUM：0.1-0.3 part；
Imidazolidinyl urea：0.1-0.5 part；
Glycine betaine：1.0-3.0 part；
Emulsifying agent：0.5-3.0 part；
Cetearyl alcohol：0.2-2.0 part；
Octyl group polydimethylsiloxane：3.0-6.0 part；
Polydimethylsiloxane：1-5.0 part；
Thickening solubility enhancing component：0.8-2.0 part；
Sargassum extract：1.0-3.0 part；
Nicotiamide：1.0-3.0 part；
Herba Dendrobii extract：1.0-5.0 part；
Essence：0.01-0.06 part.
2. a kind of blushing according to claim 1, is characterized in that：The emulsifying agent is cetearyl alcohol Fructus Canarii albi oleate
With at least one in the smooth Fructus Canarii albi oleate of Pyrusussuriensiss.
3. a kind of blushing according to claim 1, is characterized in that：The thickening solubility enhancing component includes thickening agent and solubilising
Agent, the thickening agent is the one kind in sodium acrylate and sodium acryloyldimethyl taurate copolymers, and the solubilizing agent is different ten
At least one in six alkane and Polyoxyethylene Sorbitan Monooleate.
4. a kind of blushing according to claim 1, is characterized in that：A kind of described blushing also includes that bean milk fermentation is produced
Thing filtrate, its parts by weight is 0.6-3.0.
5. a kind of blushing according to claim 4, is characterized in that：A kind of described blushing also includes licorice, its
Parts by weight are 0.1-0.3.
6. a kind of blushing according to claim 5, is characterized in that：A kind of described blushing also includes procyanidin,
Its parts by weight is 0.1-3.0.
7. a kind of blushing according to claim 1, is characterized in that：The Herba Dendrobii extract is carried in accordance with the following steps
Obtain：
A, the Herba Dendrobii for air-drying is ground into 80 mesh powder, adds in reaction vessel, by Herba Dendrobii and water 1:10 (quality：
Volume）Ratio soak 1h；
B, 85 DEG C are heated to, reflux extraction extracts 2h, filter, collect filtrate；
C, add water in reaction vessel again, by Herba Dendrobii and water 1:8 (quality：Volume）Ratio add water, be heated to 75 DEG C
Reflux, extract, 4h, filters afterwards, collects filtrate；
D, merging filtrate twice, spray drying is carried out after concentrating under reduced pressure and obtains Herba Dendrobii extract.
8. a kind of preparation method of blushing, is characterized in that, comprise the steps：
S1, A1 water is heated to 85 DEG C in water phase pot, A2 oil phase is heated to 85 DEG C in oil phase pot, is incubated 20min, stirring
Uniformly；
S2, A1 water phase and A2 oil phase being mixed, homogenizing 3min, B phase homogenizing stirring 3min is added after being cooled to 75 DEG C, then is incubated
15min；
S3,60 DEG C are cooled to, C phase are added, is stirred；
S4,45 DEG C are cooled to, D phase are added, is stirred；
S5,38 DEG C are cooled to, 200 mesh are filtered, and taken the dish out of the pot, check, are packed；
Wherein：Described A1 water mutually includes the following raw material：Water, Propylene Glycol, Carbomer, methyl hydroxybenzoate, hyaluronate sodium, glycerol,
Licorice, allantoin, EDTA disodium, imidazolidinyl urea and glycine betaine；A2 oil phase includes the following raw material：Emulsifying agent, cetearyl alcohol
Alcohol, octyl group polydimethylsiloxane and polydimethylsiloxane；B phase is：Thickening solubility enhancing component；C phase is：Sargassum extract；D phase
Including the following raw material：Bean milk tunning filtrate, nicotiamide, essence, procyanidin, Herba Dendrobii extract.
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| CN201611056664.5A CN106420536A (en) | 2016-11-25 | 2016-11-25 | Hydrated cream and preparation method thereof |
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| CN110327229A (en) * | 2019-08-09 | 2019-10-15 | 海南依贝皙生物科技有限公司 | A kind of formula of polypeptide blushing |
| CN111297761A (en) * | 2020-04-13 | 2020-06-19 | 北京悠悦百仕科技发展有限公司 | Whitening composition and preparation method and application thereof |
| CN116585210A (en) * | 2023-04-12 | 2023-08-15 | 深圳市亮而彩科技有限公司 | Hydrogel cream and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107157872A (en) * | 2017-05-08 | 2017-09-15 | 宁波易中禾生物技术有限公司 | A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof |
| CN107157872B (en) * | 2017-05-08 | 2019-11-22 | 宁波易中禾生物技术有限公司 | A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof |
| CN108542808A (en) * | 2018-07-15 | 2018-09-18 | 海南侯臣生物科技有限公司 | A kind of mountain shaddock skin cream and preparation method thereof |
| CN110327229A (en) * | 2019-08-09 | 2019-10-15 | 海南依贝皙生物科技有限公司 | A kind of formula of polypeptide blushing |
| CN111297761A (en) * | 2020-04-13 | 2020-06-19 | 北京悠悦百仕科技发展有限公司 | Whitening composition and preparation method and application thereof |
| CN116585210A (en) * | 2023-04-12 | 2023-08-15 | 深圳市亮而彩科技有限公司 | Hydrogel cream and preparation method thereof |
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