CN107157872B - A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof - Google Patents
A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof Download PDFInfo
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- CN107157872B CN107157872B CN201710316690.5A CN201710316690A CN107157872B CN 107157872 B CN107157872 B CN 107157872B CN 201710316690 A CN201710316690 A CN 201710316690A CN 107157872 B CN107157872 B CN 107157872B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing, it is made of component A and B component, the dendrobium candidum alcohol plastid contained in B component has good superdeformable, under skin hydration pressure, alcohol plastid can carry its own small 1/5 ~ 1/10 aperture of content tranmittance, deep skin can be rapidly entered, it is that dendrobium candidum extracting solution effective component is facilitated to penetrate to the skin interior effective transport vehicle, it solves the problems, such as that the generally existing penetrating power of existing skin care item is poor, improves the transdermal penetration effect of dendrobium candidum effective component；The active constituent accumulation of the dendrobium candidum facial treatment milk is high, preparation process is simple, materials safety, it is non-stimulated to skin, have effects that significantly to maintain or restore skin elasticity, reduction or repair the microgroove of skin generation, inhibit deposition, ultra-violet radiation resisting and the slowing down skin aging of lipofuscin, the formation of skin photoage and daylight sunburn caused by ultraviolet light irradiation can be effectively suppressed.
Description
Technical field
The present invention relates to cosmetics and its preparation technical field, specifically a kind of oxidation resistant dendrobium candidum skin care milk of moisturizing
Liquid and preparation method thereof.
Background technique
The mistake that wrinkle caused by clinical ultraviolet light irradiation, freckle, melanin are excessively calm, matt and elasticity reduces
Journey is referred to as light aging, mainly due to the ultraviolet B radiation (UVB) and long wave ultraviolet in solar UV (UV)
(UVA) caused by.Modern science experimental studies have found that, UVB irradiation induction body skin first generates a large amount of free radical, from
By base by a series of reaction, and then damage body skin histology.In addition to the above process, UVB can also cause body protein,
A series of reaction of functional mass such as enzyme eventually leads to body cell damage, is even more an important factor for inducing cutaneum carcinoma.UVA
Biological effect is although small, but it can penetrate skin histology, reaches skin corium, and then causes dermal tissue collagenous fibres and elastic force
The damage of fiber, the light aging morbidity effect caused are also gradually taken seriously.Ultraviolet light also results in skin and generates largely
ROS, has broken the anti-oxidant balance of body, and the activation of upstream kinases is activated to activate mitogen-activated protein kinase (MAPK),
And then the expression of c-Jun gene is raised, it improves the genetic transcription of MMPs and inhibits the synthesis of skin collagen.It is above-mentioned a series of
Approach leads to the variation of body skin, that is, is skin photoage phenomenon known to us.
With the promotion of scientific beautifying technique, people can carry out light injury caused by light aging repairing and control
It treats.At this stage, the major measure for coping with damage caused by light aging has drug therapy, laser, intense pulsed light, radio frequency, light dynamic
Power therapy, injection cosmetology and operation.Some common antioxidants such as vitamin C, vitamin E etc., by removing body
Free radical achievees the purpose that repair damage.It and is also current preventing/treating by way of painting for oral administration, outer and drug combination
Important means.In addition, drug therapy also passes through the Chinese medicine of Chemical peeling agent, chemical sunscreen agents and anti-aging, to ultraviolet light
Caused light aging is prevented and treated.
Currently, the relatively effective drug of light aging is coped with mainly based on Chemical peeling agent, chemical sunscreen agents, but these
Chemical component often brings the adverse side effects such as skin allergy.China's Traditional Chinese Medicine recognizes long history for daylight light poison,
Simultaneously a large number of studies show that some Chinese medicines have preferable light aging protective effect, therefore developed from the wide Chinese medicine in China
Satisfactory Related product has wide development prospect.Dendrobium candidum has long as the typical Chinese medicine in China
Medication history, but there is not been reported for its related uvioresistant light injury.In consideration of it, the present invention proposes that a kind of moisturizing is oxidation resistant
Dendrobium candidum facial treatment milk and preparation method thereof.
Summary of the invention
There is significant maintenance technical problem to be solved by the invention is to provide one kind or restore skin elasticity, reduce or repair
The moisturizing antioxygen of microgroove, deposition, ultra-violet radiation resisting and slowing down skin aging effect for inhibiting lipofuscin that multiple skin generates
Dendrobium candidum facial treatment milk of change and preparation method thereof.
The technical scheme of the invention to solve the technical problem is: a kind of oxidation resistant dendrobium candidum skin care of moisturizing
Lotion is made of component A and B component, and the volume ratio of the component A and the B component is (0.5-1): (3-5)；It is described
The mass percentage composition of component A include: cetearyl glucoside 1-5wt%, methyl glucoside dioleate 1-
5wt%, cetostearyl alcohol 1-3wt%, tristerin l-5wt%, saualane 2-5wt%, isopropyl myristate 0-
5wt%, isononyl isononanoate 0-10wt%, lanolin derivative 0.1-2wt%, olive oil 1-8wt%, Sweet Almond Oil 1-
8wt%, vitamin E 0.1-1wt%, glycerol 5-10wt%, plants essential oil 0.1-0.3wt%, preservative 0.05-0.5wt%,
Surplus is that the aqueous solution of dendrobium candidum extract solid content contains 2-4wt%'s in the aqueous solution in terms of the quality of the aqueous solution
Dendrobium candidum extract solid content；The B component is dendrobium candidum alcohol plastid suspension, and the dendrobium candidum alcohol plastid is mixed
The mass percentage composition of suspension includes: dendrobium candidum extract solid content 0.5-5wt%, lecithin 1-8wt%, cholesterol 0-
0.3wt%, ethyl alcohol 25-45wt%, vitamin E 0-0.1wt%, emulsifier 0-0.5wt%, surplus are water.
Preferably, the preparation process of the dendrobium candidum alcohol plastid suspension are as follows: each raw material is weighed, by the ovum
Phosphatide, cholesterol, vitamin E and emulsifier are dissolved in acetone, are removed organic solvent by decompression rotary evaporation and are formed uniformly
Film, then immobilized artificial membrane is obtained after thoroughly waving most organic solvent in vacuum oven；Then by dendrobium candidum extract solid content
It is dissolved in the ethanol water of 25-45%, is then added in the immobilized artificial membrane and carries out aquation, formation is encapsulated with dendrobium candidum alcohol matter
The dispersion liquid of body, after ultrasonic disperse, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving the iron sheet
Dendrobium nobile alcohol plastid suspension.Alternatively, the preparation process of the dendrobium candidum alcohol plastid suspension are as follows: each raw material is weighed, by institute
Lecithin, cholesterol, vitamin E and the emulsifier stated are dissolved in the ethyl alcohol of 75-95%, obtain mixed liquor；By dendrobium candidum
Extract solid content is soluble in water, obtains dendrobium candidum water phase, then at room temperature, under confined conditions while stirring by the mixing
Liquid is slowly injected into the dendrobium candidum water phase, stirring, successively the filtering with microporous membrane whole grain through 0.45 μm, 0.22 μm, i.e.,
Obtain the dendrobium candidum alcohol plastid suspension.The dendrobium candidum alcohol plastid contained in dendrobium candidum alcohol plastid suspension is in capsule
Blister, appearance is in the sphere or spheroid of rule, and partial size is between 30-300nm.
Preferably, the emulsifier is Montanov 82, Montanov 202, Prolipid 131 and E-
At least one of Inspire 343.
Preferably, the preparation process of the dendrobium candidum extract solid content are as follows: by the fresh item of dendrobium candidum with it is pure
After water is according to the weight ratio mixing of 1:15, three times through the extraction of multi-functional wall-breaking machine, it is centrifuged under 4500r/min revolving speed every time
20min merges after extraction and extracts supernatant, obtains dendrobium candidum extracting solution, obtains after dry to the dendrobium candidum extracting solution
The dendrobium candidum extract solid content.The present invention prepares dendrobium candidum with dendrobium candidum all herbal medicine, using extraction process by water
Extracting solution, it is intended to farthest retain the effective active compositions such as dendrobium polysaccharide and dendrobine, and then play its maximum skin care function
Effect.The extraction operation of the dendrobium candidum extracting solution is simple and easy, recovery rate is high, impurity is few in extracting solution, can effectively reduce sensitization
The source of substance, it is ensured that dendrobium candidum facial treatment milk of the present invention is safer on the skin, non-stimulated.
The dendrobium candidum extracting solution that water raises is not easy to save, and the present invention selects different drying process, is the later period
Processing provides selection gist.Specifically, to the drying process of the dendrobium candidum extracting solution are as follows: by the dendrobium candidum
Extracting solution is divided into ceramic whiteware disk, then ceramic whiteware disk is placed in baking oven and carries out heated-air drying, and drying temperature is 90 DEG C, drying time
For 4h.Alternatively, to the drying process of the dendrobium candidum extracting solution are as follows: dividing the dendrobium candidum extracting solution to ceramic whiteware
In disk, in the environment of vacuum degree is 0.9MPa, for 24 hours with 60 DEG C of drying temperature vacuum drying.Alternatively, to the iron sheet stone
The drying process of dry measure used in former times extracting solution are as follows: the dendrobium candidum extracting solution is divided to surface plate, is placed at -80 DEG C and is freeze-dried
72h.Alternatively, to the drying process of the dendrobium candidum extracting solution are as follows: after the dendrobium candidum extracting solution is diluted 4 times
It is spray-dried in spray dryer, the inlet air temperature of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C.
A kind of preparation method of the oxidation resistant dendrobium candidum facial treatment milk of above-mentioned moisturizing, comprising the following steps:
(1) it weighs and prepares various raw materials；
(2) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is 2-
The aqueous solution of the dendrobium candidum extract solid content of 4wt%, then water soluble ingredient cetearyl Portugal is added into the aqueous solution
Glucosides, methyl glucoside dioleate and glycerol, are heated to 70-80 DEG C after mixing evenly, obtain water phase；By cetearyl alcohol
Alcohol, tristerin, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative, olive oil, dessert almond
Oil, vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 70-80 DEG C, are stirred evenly, and obtain oily phase, for use；So
The water phase is poured slowly into the oily phase afterwards, obtains component A, stir 10-30min clockwise, the temperature to the component A
Degree is when being down to 45-55 DEG C, is added B component dendrobium candidum alcohol plastid suspension, and the volume ratio of component A and B component is (0.5-1):
(3-5) is stirred evenly and is obtained the oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
Compared with the prior art, the advantages of the present invention are as follows:
(1) the oxidation resistant dendrobium candidum facial treatment milk of moisturizing disclosed by the invention, active constituent accumulation is high, preparation process
Simply, materials safety, it is non-stimulated to skin, there is significant maintenance or recovery skin elasticity, reduction or reparation skin to generate thin
Ultraviolet light irradiation institute can be effectively suppressed in line, deposition, ultra-violet radiation resisting and the slowing down skin aging effect for inhibiting lipofuscin
Caused by skin photoage and daylight sunburn formation.
(2) contain dendrobium candidum alcohol plastid in dendrobium candidum facial treatment milk disclosed by the invention, be a kind of superminiature capsule
Carrier is steeped, which has good superdeformable, and under skin hydration pressure, alcohol plastid can carry content tranmittance
Its own small 1/5~1/10 aperture, can rapidly enter deep skin, be that dendrobium candidum extracting solution effective component is facilitated to permeate
Effective transport vehicle in skin solves the problems, such as that the generally existing penetrating power of existing skin care item is poor, improves iron sheet
The transdermal penetration effect of dendrobium nobile effective component.
Detailed description of the invention
Fig. 1 is dendrobium candidum facial treatment milk in embodiment to the Scavenging activity testing result of DPPH free radical；
Fig. 2 is dendrobium candidum facial treatment milk in embodiment to the Scavenging activity testing result of ABTS free radical；
Fig. 3 be in embodiment at the end of light Ageing Model modeling after six groups of mouse skin HE slice tissue morphology (×
200)；
Fig. 4 is dendrobium candidum facial treatment milk in embodiment to the investigation result of moisture of skin moisture-keeping function；
Fig. 5 is the investigation result that dendrobium candidum facial treatment milk acts on skin oil holding in embodiment.
Specific embodiment
The present invention will be described in further detail below with reference to the embodiments of the drawings.
The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing of embodiment one, is made of component A and B component, component A and B group
The volume ratio divided is 0.8:5；The mass percentage composition of component A includes: cetearyl glucoside 1.5wt%, methyl glucose
Glucosides dioleate 1.2wt%, cetostearyl alcohol 2wt%, tristerin 2.2wt%, saualane 3wt%, myristic acid
Isopropyl ester 2wt%, isononyl isononanoate 1.8wt%, lanolin derivative 1.6wt%, olive oil 3wt%, Sweet Almond Oil
5wt%, vitamin E 0.5wt%, glycerol 5wt%, plants essential oil 0.2wt%, preservative 0.25wt%, surplus are dendrobium candidum
The aqueous solution of extract solid content, in terms of the quality of the aqueous solution, the dendrobium candidum extract in the aqueous solution containing 3wt% is solid
Shape object；B component is dendrobium candidum alcohol plastid suspension, and the mass percentage composition of dendrobium candidum alcohol plastid suspension includes: iron
Skin Herba Dendrobii extract solid content 2.5wt%, lecithin 5wt%, cholesterol 0.2wt%, ethyl alcohol 32wt%, vitamin E
82 emulsifier 0.28wt% of 0.06wt%, Montanov, surplus is water；The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing
Preparation method the following steps are included:
(1) it weighs and prepares various raw materials；
(2) preparation of dendrobium candidum extract solid content: by the fresh item of dendrobium candidum and pure water according to the weight ratio of 1:15
After mixing, three times through the extraction of multi-functional wall-breaking machine, 20min is centrifuged under 4500r/min revolving speed every time, merges after extraction and extract
Clear liquid obtains dendrobium candidum extracting solution, and dendrobium candidum extracting solution is divided into ceramic whiteware disk, then by ceramic whiteware disk be placed in baking oven into
Row heated-air drying, drying temperature are 90 DEG C, drying time 4h, obtain dendrobium candidum extract solid content after dry；
(3) preparation of dendrobium candidum alcohol plastid suspension: weighing each raw material, by lecithin, cholesterol, vitamin E and
82 emulsifier of Montanov is dissolved in acetone, is removed organic solvent by decompression rotary evaporation and is formed uniform film, then true
Immobilized artificial membrane is obtained after thoroughly waving most organic solvent in empty drying box；Then dendrobium candidum extract solid content is dissolved in 24-45%
Ethanol water in, be then added in immobilized artificial membrane and carry out aquation, formed and be encapsulated with the dispersion liquid of dendrobium candidum alcohol plastid, ultrasound
After dispersion, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving dendrobium candidum alcohol plastid suspension；
(4) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is 3wt%
Dendrobium candidum extract solid content aqueous solution, then into the aqueous solution add water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerol are heated to 80 DEG C after mixing evenly, obtain water phase；By cetostearyl alcohol, stearic acid
Glyceride, methyl glucoside dioleate, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative,
Olive oil, Sweet Almond Oil, vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 80 DEG C, are stirred evenly, obtain oil
Phase, for use；Then water phase is poured slowly into oily phase, obtains component A, stirs 10-30min clockwise, the temperature to the component A
When being down to 50 DEG C, B component dendrobium candidum alcohol plastid suspension is added, the volume ratio of component A and B component is 0.8:5, is stirred evenly
Obtain the oxidation resistant dendrobium candidum facial treatment milk of moisturizing of embodiment one.
The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing of embodiment two, is made of component A and B component, component A and B group
The volume ratio divided is 1:5；The mass percentage composition of component A includes: cetearyl glucoside 1.3wt%, methyl glucoside
Glycosides dioleate 2.7wt%, cetostearyl alcohol 1wt%, tristerin 3.5wt%, saualane 4.4wt%, isononanoic acid are different
Nonyl ester 0.7wt%, lanolin derivative 0.5wt%, olive oil 1.2wt%, Sweet Almond Oil 1.5wt%, vitamin E
0.1wt%, glycerol 8wt%, plants essential oil 0.1wt%, preservative 0.5wt%, surplus are dendrobium candidum extract solid content
Aqueous solution, the dendrobium candidum extract solid content in terms of the quality of the aqueous solution, in the aqueous solution containing 2wt%；B component is iron
Skin dendrobium nobile alcohol plastid suspension, the mass percentage composition of dendrobium candidum alcohol plastid suspension include: that dendrobium candidum extract is solid
Shape object 3wt%, lecithin 4.5wt%, ethyl alcohol 43wt%, 202 emulsifier of vitamin E 0.03wt%, Montanov
0.5wt%, surplus are water；The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing the following steps are included:
(1) it weighs and prepares various raw materials；
(2) preparation of dendrobium candidum extract solid content: by the fresh item of dendrobium candidum and pure water according to the weight ratio of 1:15
After mixing, three times through the extraction of multi-functional wall-breaking machine, 20min is centrifuged under 4500r/min revolving speed every time, merges after extraction and extract
Clear liquid obtains dendrobium candidum extracting solution, and dendrobium candidum extracting solution is divided into ceramic whiteware disk, in the environment that vacuum degree is 0.9MPa
Under, for 24 hours with 60 DEG C of drying temperature vacuum drying, dendrobium candidum extract solid content is obtained after dry；
(3) preparation of dendrobium candidum alcohol plastid suspension: weighing each raw material, by lecithin, cholesterol, vitamin E and
202 emulsifier of Montanov is dissolved in the ethyl alcohol of 75-95%, obtains mixed liquor；Dendrobium candidum extract solid content is dissolved in
In water, dendrobium candidum water phase is obtained, then at room temperature, under confined conditions mixed liquor is slowly injected into dendrobium candidum water phase while stirring
In, stirring, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving dendrobium candidum alcohol plastid suspension；
(4) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is 2wt%
Dendrobium candidum extract solid content aqueous solution, then into the aqueous solution add water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerol are heated to 78 DEG C after mixing evenly, obtain water phase；By cetostearyl alcohol, stearic acid
Glyceride, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 78 DEG C, are stirred evenly, and obtain oily phase, for use；Then water phase is slow
It pours into oily phase, obtains component A, stir 10-30min clockwise, when the temperature of the component A is down to 45 DEG C, B component iron is added
The volume ratio of skin dendrobium nobile alcohol plastid suspension, component A and B component is 1:5, stirs evenly the moisturizing antioxygen for obtaining embodiment two
The dendrobium candidum facial treatment milk of change.
The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing of embodiment three, is made of component A and B component, component A and B group
The volume ratio divided is 0.6:4；The mass percentage composition of component A includes: cetearyl glucoside 2.1wt%, methyl glucose
Glucosides dioleate 3wt%, cetostearyl alcohol 2.5wt%, tristerin 1.7wt%, saualane 2.9wt%, nutmeg
Isopropyl propionate 4.9wt%, lanolin derivative 1.8wt%, olive oil 4.5wt%, Sweet Almond Oil 6wt%, vitamin E
0.8wt%, glycerol 7wt%, plants essential oil 0.25wt%, preservative 0.1wt%, surplus are dendrobium candidum extract solid content
Aqueous solution, the dendrobium candidum extract solid content in terms of the quality of the aqueous solution, in the aqueous solution containing 4wt%；B component is iron
Skin dendrobium nobile alcohol plastid suspension, the mass percentage composition of dendrobium candidum alcohol plastid suspension include: that dendrobium candidum extract is solid
Shape object 1.5wt%, lecithin 2.3wt%, cholesterol 0.3wt%, ethyl alcohol 30wt%, vitamin E 0.1wt%, Prolipid
131 emulsifier 0.3wt%, surplus are water；The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing includes following step
It is rapid:
(1) it weighs and prepares various raw materials；
(2) preparation of dendrobium candidum extract solid content: by the fresh item of dendrobium candidum and pure water according to the weight ratio of 1:15
After mixing, three times through the extraction of multi-functional wall-breaking machine, 20min is centrifuged under 4500r/min revolving speed every time, merges after extraction and extract
Clear liquid obtains dendrobium candidum extracting solution, and dendrobium candidum extracting solution is divided to surface plate, is placed at -80 DEG C and is freeze-dried
72h obtains dendrobium candidum extract solid content after dry；
(3) preparation of dendrobium candidum alcohol plastid suspension: weighing each raw material, by lecithin, cholesterol, vitamin E and
131 emulsifier of Prolipid is dissolved in the ethyl alcohol of 75-95%, obtains mixed liquor；Dendrobium candidum extract solid content is dissolved in
In water, dendrobium candidum water phase is obtained, then at room temperature, under confined conditions mixed liquor is slowly injected into dendrobium candidum water phase while stirring
In, stirring, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving dendrobium candidum alcohol plastid suspension；
(4) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is 4wt%
Dendrobium candidum extract solid content aqueous solution, then into the aqueous solution add water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerol are heated to 70 DEG C after mixing evenly, obtain water phase；By cetostearyl alcohol, stearic acid
Glyceride, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 70 DEG C, are stirred evenly, and obtain oily phase, for use；Then water phase is slow
It pours into oily phase, obtains component A, stir 10-30min clockwise, when the temperature of the component A is down to 50 DEG C, B component iron is added
The volume ratio of skin dendrobium nobile alcohol plastid suspension, component A and B component is 0.6:4, stir evenly obtain embodiment three moisturizing it is anti-
The dendrobium candidum facial treatment milk of oxidation.
The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing of example IV, is made of component A and B component, component A and B group
The volume ratio divided is 0.5:3；The mass percentage composition of component A includes: cetearyl glucoside 4.8wt%, methyl glucose
Glucosides dioleate 4.5wt%, cetostearyl alcohol 3wt%, tristerin 4.6wt%, saualane 2wt%, myristic acid
Isopropyl ester 3.1%, isononyl isononanoate 8.4%, lanolin derivative 0.2wt%, olive oil 8wt%, Sweet Almond Oil 7.5%,
Vitamin e1 wt%, glycerol 10wt%, plants essential oil 0.15wt%, preservative 0.45wt%, surplus are dendrobium candidum extract
The aqueous solution of solid content, the dendrobium candidum extract solid in terms of the quality of the aqueous solution, in the aqueous solution containing 2.5wt%
Object；B component is dendrobium candidum alcohol plastid suspension, and the mass percentage composition of dendrobium candidum alcohol plastid suspension includes: iron sheet
Herba Dendrobii extract solid content 3wt%, lecithin 4.7wt%, cholesterol 0.1wt%, 343 cream of ethyl alcohol 35wt%, E-Inspire
Agent 0.2wt%, surplus are water；The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing the following steps are included:
(1) it weighs and prepares various raw materials；
(2) preparation of dendrobium candidum extract solid content: by the fresh item of dendrobium candidum and pure water according to the weight ratio of 1:15
After mixing, three times through the extraction of multi-functional wall-breaking machine, 20min is centrifuged under 4500r/min revolving speed every time, merges after extraction and extract
Clear liquid obtains dendrobium candidum extracting solution, is spray-dried in spray dryer after dendrobium candidum extracting solution is diluted 4 times,
The inlet air temperature of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C, obtains dendrobium candidum extract solid content after dry；
(3) preparation of dendrobium candidum alcohol plastid suspension: weighing each raw material, by lecithin, cholesterol, vitamin E and E-
343 emulsifier of Inspire is dissolved in acetone, is removed organic solvent by decompression rotary evaporation and is formed uniform film, then true
Immobilized artificial membrane is obtained after thoroughly waving most organic solvent in empty drying box；Then dendrobium candidum extract solid content is dissolved in 24-45%
Ethanol water in, be then added in immobilized artificial membrane and carry out aquation, formed and be encapsulated with the dispersion liquid of dendrobium candidum alcohol plastid, ultrasound
After dispersion, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving dendrobium candidum alcohol plastid suspension；
(4) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is
The aqueous solution of the dendrobium candidum extract solid content of 2.5wt%, then water soluble ingredient cetearyl is added into the aqueous solution
Glucoside, methyl glucoside dioleate and glycerol, are heated to 75 DEG C after mixing evenly, obtain water phase；By cetostearyl alcohol,
Tristerin, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil,
Vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 75 DEG C, are stirred evenly, and obtain oily phase, for use；Then by water
It is mutually poured slowly into oily phase, obtains component A, stir 10-30min clockwise, when the temperature of the component A is down to 40 DEG C, B is added
The volume ratio of component dendrobium candidum alcohol plastid suspension, component A and B component is 0.5:3, stirs evenly and obtains example IV
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
DPPH exists usually in the form of stable alcohol free radical, and DPPH free radical scavenging ability is also most common external
Antioxidant system.After the dendrobium candidum facial treatment milk of one~example IV of embodiment is diluted, it is detected to DPPH free radical
Scavenging activity, the result is shown in Figure 1.It can be seen from figure 1 that the dendrobium candidum facial treatment milk of one~example IV of embodiment is to DPPH free radical
Clearance rate overall performance go out certain difference, but whole show preferable DPPH free radical scavenging ability, otherness
It is smaller, show that the dendrobium candidum facial treatment milk of one~example IV of embodiment has fabulous antioxidant activity.
ABTS+Stable water-soluble free radical, ABTS can be formed+Scavenging activity be external common anti-oxidant comment
Valence system.After the dendrobium candidum facial treatment milk of one~example IV of embodiment is diluted, its removing to ABTS free radical is detected
As a result ability is shown in Fig. 2.As shown in Figure 2, the removing with the raising of dendrobium candidum facial treatment milk concentration, to ABTS free radical
Effect gradually rises, but the facial treatment milk entirety free radical scavenging ability of four embodiments shows certain otherness, whole
Body shows themselves in that three > example IV > embodiment of embodiment, two > embodiment one.
By taking the dendrobium candidum facial treatment milk of embodiment one as an example, the test of anti-mouse dermal photodamage, internal water are carried out to it
Divide moisture-retaining capacity and the experiment of oil holding capacity.
1, dermal photodamage is tested
By 54 ICR mouse, be randomly divided into 6 groups: normal group, control group, VE smearing group, low dosage lotion smearing group, in
Dosage lotion smearing group, high dose lotion smearing group, in which: normal group is not irradiated by ultraviolet light, the irradiation of control group ultraviolet light, VE
Smearing group smears VE and ultraviolet light irradiation (VE applying amount is 500mg/kg), low dosage smearing group smearing dendrobium candidum lotion are simultaneously purple
Outside line irradiation (lotion applying amount is 100mg/kg), middle dosage smearing group smears dendrobium candidum lotion and ultraviolet light irradiates (lotion
Applying amount is 250mg/kg), high dose smearing group smears dendrobium candidum lotion, and simultaneously (lotion applying amount is 500mg/ for ultraviolet light irradiation
kg)。
Before experiment starts, scissors trims mouse skin hair, depilatory cream depilation, and simulation daylight carries out depilation ICR mouse
Ultraviolet light irradiation makes mouse light loss wound model, shifts to an earlier date 0.5h according to above-mentioned dosage before irradiation and smears, exposure intensity are as follows: purple
(the 2.86 μ w/cm of outside line A fluorescent tube two2), (the 175 μ w/cm of Ultraviolet B fluorescent tube one2), irradiation time are as follows: initial daily 1h, three
Daily 2h after it, daily 3h, keeps daily 5h later after a week, until control group mice skin thickens, occurs wide and deep
Wrinkle, take around Continuous irradiation 10 weeks, irradiation terminates.It is raised under 25 DEG C of indoor environments, mouse is given once daily and freely drinks
Food and drinking-water, during which without death condition.Experimental animal divides cage by group, raises under 25 DEG C of indoor environments, makes light Ageing Model.
During experiment, mouse similarly free diet and drinking-water is given once daily.
At the end of light Ageing Model modeling, entire effect of the observation ultraviolet light irradiation to ICR back of mice depilation skin: see
Discovery is examined, normal to organize that mouse skin texture is normal, and skin is ruddy glossy, no wrinkle and corresponding pigment deposition phenomenon；Control
Lumps accumulation is presented in group mouse skin, hence it is evident that visible elasticity reduces and melanin deposition, while skin is matt, shows the source of an allusion
The skin photoage clinical symptoms of type illustrate mouse light Ageing Model modeling success；VE smearing group mouse skin is compared with control group skin
Skin glossiness makes moderate progress, and rare wrinkle of skin lumps packing phenomenon, surface only have a small amount of pigmentation；Low dosage cream
Liquid smearing group mouse skin makes moderate progress compared with control group skin shine, rare lumps packing phenomenon, smears result phase with VE
Seemingly, also there is a little Skin pigmentation phenomenon；Middle dosage lotion smearing group mouse skin and high dose lotion smearing group mouse skin
Skin is significantly improved compared with control group mice skin significant improvement, mouse skin glossiness, and skin surface without conspicuousness wrinkle with
The accumulation of skin lumps, shows preferable photoaging damage repair, shows the iron sheet stone of one~example IV of embodiment
Dry measure used in former times facial treatment milk has good light injury repair function.
At the end of light Ageing Model modeling, skin HE slice is carried out to six groups of mouse, observes the skin group of mouse light injury
Form is knitted, as a result as shown in Figure 3.In Fig. 3, a is normal group, and b is control group, and c is VE smearing group, and d is low dosage lotion smearing
Group, e are middle dosage lotion smearing group, and f is high dose lotion smearing group.From the figure 3, it may be seen that normally group each layer structure of mouse skin is complete
Whole, epidermis is connect clear with corium relatively, and epidermal thickness is moderate, and corium is without hyperplasia, and corresponding collagenous fiber bundle is evenly distributed,
It is not broken；Control group mice skin epidermis obviously thickens, skin texture be layered unintelligible, skin corium conspicuousness hyperplasia, this with
Above-mentioned mouse macroscopic observation result mouse skin Flexible change is consistent, and a series of histology and morphology structure shows mouse light aging
Model modeling success；VE smearing group mouse shows certain compared with low dosage lotion smearing group mouse is compared with control group mice
Light injury repair, first dermal layer of the skin thickness are substantially reduced compared with control group, at the same corresponding collagenous fiber bundle distribution compared with
Control group is also greatly improved；Middle dosage lotion smearing group mouse and the skin of high dose lotion smearing group mouse are then shown
Preferable light injury repairing effect also indicates that the dendrobium candidum facial treatment milk of one~example IV of embodiment has good light loss
Hurt repair function.
2, internal water moisture-retaining capacity is tested
By 18 ICR mouse, be randomly divided into 2 groups: control group does not smear dendrobium candidum facial treatment milk, and experimental group smears iron sheet
Dendrobium nobile facial treatment milk investigates the dendrobium candidum facial treatment milk of embodiment one to moisture of skin moisture-keeping function.Fig. 4 is dendrobium candidum shield
Investigation result of the skin lotion to moisture of skin moisture-keeping function.As can be seen from Figure 4, initial stage, the mouse of experimental group are smeared in facial treatment milk
Skin surface moisture content is sharply increased, and rises to 61.6% by 30.6% before smearing, effectively improves skin moisture content, table
Reveal very strong skin moisture-keeping effect, shows that dendrobium candidum facial treatment milk has good moisture moistening effect.From time shaft
It sees, the moisture of skin of experimental mice is consistently higher than control group mice, shows stronger moisture of skin moisture-keeping efficacy.
3, the experiment of oil holding capacity is by 18 ICR mouse, and be randomly divided into 2 groups: control group does not smear dendrobium candidum skin care
Lotion, experimental group smear dendrobium candidum facial treatment milk, and the dendrobium candidum facial treatment milk for investigating embodiment one keeps skin oil
Effect.Fig. 5 is the investigation result that dendrobium candidum facial treatment milk acts on skin oil holding.As can be seen from Figure 5, it is applied in facial treatment milk
It smears initial stage, the murine skin surface oil content of experimental group is sharply increased, and rises to 27.7% by 14.8% before smearing, and test
The skin oil content of group mouse is consistently higher than control group mice, shows good skin oil and keeps effect.
Claims (10)
1. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing, it is characterised in that be made of component A and B component, the A group
Divide and the volume ratio of the B component is (0.5-1): (3-5)；The mass percentage composition of the component A includes: that spermaceti is hard
Aliphatic radical glucoside 1-5wt%, methyl glucoside dioleate 1-5wt%, cetostearyl alcohol 1-3wt%, tristerin
L-5wt%, saualane 2-5wt%, isopropyl myristate 0-5wt%, isononyl isononanoate 0-10wt%, lanolin derivative
0.1-2wt%, olive oil 1-8wt%, Sweet Almond Oil 1-8wt%, vitamin E 0.1-1wt%, glycerol 5-10wt%, plant essence
Oily 0.1-0.3wt%, preservative 0.05-0.5wt%, surplus is the aqueous solution of dendrobium candidum extract solid content, water-soluble with this
The quality meter of liquid, the dendrobium candidum extract solid content containing 2-4wt% in the aqueous solution；The B component is dendrobium candidum
Alcohol plastid suspension, the mass percentage composition of the dendrobium candidum alcohol plastid suspension include: that dendrobium candidum extract is solid
Shape object 0.5-5wt%, lecithin 1-8wt%, cholesterol 0-0.3wt%, ethyl alcohol 25-45wt%, vitamin E 0-0.1wt%,
Emulsifier 0-0.5wt%, surplus are water.
2. the oxidation resistant dendrobium candidum facial treatment milk of a kind of moisturizing according to claim 1, it is characterised in that the iron
The preparation process of skin dendrobium nobile alcohol plastid suspension are as follows: each raw material is weighed, by the lecithin, cholesterol, vitamin E and emulsification
Agent is dissolved in acetone, is removed organic solvent by decompression rotary evaporation and is formed uniform film, then in vacuum oven thoroughly
Immobilized artificial membrane is obtained after waving most organic solvent；Then dendrobium candidum extract solid content is dissolved in the ethanol water of 25-45%, then
It is added in the immobilized artificial membrane and carries out aquation, form the dispersion liquid for being encapsulated with dendrobium candidum alcohol plastid, after ultrasonic disperse, successively
Through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving the dendrobium candidum alcohol plastid suspension.
3. the oxidation resistant dendrobium candidum facial treatment milk of a kind of moisturizing according to claim 1, it is characterised in that the iron
The preparation process of skin dendrobium nobile alcohol plastid suspension are as follows: each raw material is weighed, by the lecithin, cholesterol, vitamin E and emulsification
Agent is dissolved in the ethyl alcohol of 75-95%, obtains mixed liquor；Dendrobium candidum extract solid content is soluble in water, obtain iron sheet stone
The mixed liquor then at room temperature, is under confined conditions slowly injected into the dendrobium candidum water phase by dry measure used in former times water phase while stirring,
Stirring, successively through 0.45 μm, 0.22 μm of filtering with microporous membrane whole grain to get arriving the dendrobium candidum alcohol plastid suspension.
4. the oxidation resistant dendrobium candidum facial treatment milk of a kind of moisturizing according to claim 1, it is characterised in that the cream
Agent is at least one of Montanov 82, Montanov 202, Prolipid 131 and E-Inspire 343.
5. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing, feature described in any one of -4 exist according to claim 1
In the preparation process of the dendrobium candidum extract solid content are as follows: by the fresh item of dendrobium candidum and pure water according to the weight of 1:15
After mixing, three times through the extraction of multi-functional wall-breaking machine, 20min is centrifuged under 4500r/min revolving speed every time, merges after extraction and extract
Supernatant obtains dendrobium candidum extracting solution, obtains the dendrobium candidum extract after dry to the dendrobium candidum extracting solution
Solid content.
6. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that the iron sheet
The drying process of dendrobium extract are as follows: the dendrobium candidum extracting solution is divided into ceramic whiteware disk, then ceramic whiteware disk is placed in baking
Heated-air drying is carried out in case, drying temperature is 90 DEG C, drying time 4h.
7. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that the iron sheet
The drying process of dendrobium extract are as follows: the dendrobium candidum extracting solution is divided into ceramic whiteware disk, is 0.9MPa in vacuum degree
In the environment of, for 24 hours with 60 DEG C of drying temperature vacuum drying.
8. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that the iron sheet
The drying process of dendrobium extract are as follows: the dendrobium candidum extracting solution is divided to surface plate, is placed in freeze at -80 DEG C and do
Dry 72h.
9. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that the iron sheet
The drying process of dendrobium extract are as follows: be sprayed in spray dryer after the dendrobium candidum extracting solution is diluted 4 times
Dry, the inlet air temperature of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C.
10. a kind of preparation method of the oxidation resistant dendrobium candidum facial treatment milk of moisturizing described in claim 1, it is characterised in that packet
Include following steps:
(1) it weighs and prepares various raw materials；
(2) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is 2-4wt%'s
The aqueous solution of dendrobium candidum extract solid content, then water soluble ingredient cetearyl glucoside, first are added into the aqueous solution
Base glucoside dioleate and glycerol, are heated to 70-80 DEG C after mixing evenly, obtain water phase；By cetostearyl alcohol, stearic acid
Glyceride, saualane, isopropyl myristate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 70-80 DEG C, are stirred evenly, and obtain oily phase, for use；It then will be described
Water phase be poured slowly into the oily phase, obtain component A, stir 10-30min clockwise, the temperature to the component A is down to
At 45-55 DEG C, B component dendrobium candidum alcohol plastid suspension is added, the volume ratio of component A and B component is (0.5-1): (3-5),
It stirs evenly and obtains the oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
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| CN103585053A (en) * | 2013-10-30 | 2014-02-19 | 广州品赫化妆品有限公司 | Dendrobium-extract-containing composition and preparation method thereof |
| CN105125435A (en) * | 2015-08-18 | 2015-12-09 | 广州栋方生物科技股份有限公司 | Moisturizing composition as well as preparation method and application thereof |
| CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
| CN106420536A (en) * | 2016-11-25 | 2017-02-22 | 上海娇云日化有限公司 | Hydrated cream and preparation method thereof |
| CN106727164A (en) * | 2017-02-16 | 2017-05-31 | 中山卡丝生物科技有限公司 | A kind of moisture-keeping composition and its preparation method and application |
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| WO2013040395A2 (en) * | 2011-09-14 | 2013-03-21 | Nefeli Corp. | Herbal skin care composition |
| KR101570847B1 (en) * | 2013-08-13 | 2015-11-20 | 주식회사 한국화장품제조 | Cosmetic composition including an extract of the tissue-cultured dendrobium candidum multi-shoots |
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| CN103585053A (en) * | 2013-10-30 | 2014-02-19 | 广州品赫化妆品有限公司 | Dendrobium-extract-containing composition and preparation method thereof |
| CN105125435A (en) * | 2015-08-18 | 2015-12-09 | 广州栋方生物科技股份有限公司 | Moisturizing composition as well as preparation method and application thereof |
| CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
| CN106420536A (en) * | 2016-11-25 | 2017-02-22 | 上海娇云日化有限公司 | Hydrated cream and preparation method thereof |
| CN106727164A (en) * | 2017-02-16 | 2017-05-31 | 中山卡丝生物科技有限公司 | A kind of moisture-keeping composition and its preparation method and application |
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