CN105125435A - Moisturizing composition as well as preparation method and application thereof - Google Patents
Moisturizing composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics and particularly relates to a moisturizing composition as well as a preparation method and application thereof. The moisturizing composition is mainly composed of 10-25 parts of plant extractive liposome, 3-10 parts of dendrobium officinale extractive, 3-10 parts of aloe extractive, 0-3 parts of natural moisturizing factors and 0-3 parts of ceramide, wherein the plant extractives comprise a dendrobium officinale extractive and a grape seed extractive. The preparation method for the moisturizing composition comprises the following steps: coating the dendrobium officinale extractive and the grape seed extractive with liposome, and then mixing the liposome with the dendrobium officinale extractive, the aloe extractive, the natural moisturizing factors and ceramide so as to obtain the moisturizing composition. The moisturizing composition provided by the invention can reach dermis to repair dermis stroma cells, promote synthesis of collagen, elastin and mucopolysaccharide, and improve the composition and structure of the dermis stroma, thereby realizing the effects of deeply replenishing water and repairing the dermis and solving the problem of skin drying basically.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of moisture-keeping composition and its production and use.
Background technology
Along with the raising of people's living standard, people more and more pay attention to nursing to autologous skin and maintenance.Healthy skin should be smooth moist whippy, and this depends primarily on the content of moisture in skin.In recent years, people work for a long time in the environment of air-conditioned room or drying, and it is day by day remarkable that skin lacks water problem, makes the skin of people more and more drier, and skin aging speed is accelerated.The oils and fats skin protection in past can not meet the requirement of modern to replenishing water and preserving moisture cosmetics, and increasing people likes both having good moisture retention energy, simultaneously also containing to the nutritious effect of skin and the little natural extract wetting agent of side effect.
Chinese patent application 201210375730.0 discloses a kind of pure natural moisture-keeping cosmetics, described cosmetics adopt the natural plant extraction things such as seaweed extract thing, olive oil, aloe extract and akala extract to be that active component is made, when using these cosmetics, there is health, nothing relies on, and the advantage substantially had no side effect.But seaweed extract thing, aloe extract and akala extract are oxidizable, and moistening effect persistence is poor, and the moisturizing ingredient of extract can only arrive horny layer, cannot penetrate into skin corium, thus cannot fundamentally solve xerodermatic problem.
Chinese patent CN102018652B discloses a kind of binary moisturizing system skin care item, described skin care item are made up of leucojum aestivum bulb extract, sponge extract, sodium lactate and pentanediol, this Moisturizer can get through skin aquaporin at skin surface foundation ecological lock moisture film and bottom, top layer lock water, bottom moisturizing, forms skin binary moisturizing system.But, leucojum aestivum bulb extract and sponge extract oxidizable, moistening effect persistence is poor, cannot reach the requirement of modern to moisturizing moisturizing effect, be unfavorable for the promotion and application of these binary moisturizing system skin care item.
Current moisture-keeping cosmetics ubiquity active component is oxidizable, moistening effect persistence is poor, moisture-keeping function can only rest on horny layer, fundamentally cannot solve the defect of xerosis cutis problem.Therefore, research is sent out and is outputed that a kind of moistening effect persistence is good, moistening effect can penetrate into skin corium, and the cosmetics fundamentally solving xerosis cutis problem are important directions of research at present.
Summary of the invention
In order to overcome, active component in prior art moisture-keeping cosmetics is oxidizable, moistening effect persistence is poor, moisture-keeping function can only rest on horny layer, fundamentally cannot solve the shortcoming of xerosis cutis problem, the object of this invention is to provide a kind of moisture-keeping composition and its production and use, to solve the problem.
A kind of moisture-keeping composition provided by the invention, comprises following component and parts by weight thereof:
Plant extract composite lipidosome 10-25 part, Herba Dendrobii extract 3-10 part, Aloe extract 3-10 part, nature moisturizing factor 0-3 part and ceramide 0-3 part.
Further, moisture-keeping composition provided by the invention is preferably following component:
Plant extract composite lipidosome 15 parts, Herba Dendrobii extract 5 parts, Aloe extract 5 parts, nature moisturizing factor 1 part and ceramide 0.5 part.
Further, described plant extract fat is Herba Dendrobii extract and Semen Vitis viniferae extract.
Further, in described plant extract, the weight ratio of Herba Dendrobii extract and Semen Vitis viniferae extract is 1-5:0.5-3, and the weight ratio of described Herba Dendrobii extract and Semen Vitis viniferae extract is preferably 3:1.
Further, described nature moisturizing factor is one in glucosamine and sodium lactate or its compositions.
Semen Vitis viniferae extract is the new and effective Natural antioxidant can not synthesized in a kind of human body of extracting from Semen Vitis viniferae.Containing abundant polysaccharide in Herba Dendrobii extract, these polysaccharide have significant moisturizing, reparation and antioxidative effect, and stable in properties.The present invention utilizes liposome technology, Herba Dendrobii extract and Semen Vitis viniferae extract are wrapped in liposome, because liposome is similar to biofilm structure, can be inserted in the lipid layer of cell membrane, the Herba Dendrobii extract be wrapped in liposome and Semen Vitis viniferae extract are transported to skin corium.Herba Dendrobii extract and Semen Vitis viniferae extract can repair stromal cell in skin corium, promote the synthesis of collagen protein, elastin laminin and mucopolysaccharide, improve the Nomenclature Composition and Structure of Complexes of skin corium substrate, thus reach the effect of deep water supplement and maintenance skin corium, can fundamentally solve xerodermatic problem.
Be main moisturizing materials with the polysaccharide in Herba Dendrobii extract and Aloe extract in moisture-keeping composition provided by the invention, polysaccharide in Herba Dendrobii extract and Aloe extract has significant moisturizing, reparation and antioxidative ability, supplementary skin moisture can be continued, strengthen elasticity and the plumpness of skin.And the polysaccharide in Herba Dendrobii extract and Aloe extract can also form protective barrier at skin surface, prevents water loss, further extend the moisture preserving time of this moisture-keeping composition, strengthen moistening effect.Meanwhile, Herba Dendrobii extract and Aloe extract also have antiinflammatory, antibacterial effect at horny layer, have a better role to acne, inflammatory skin and coarse skin tool.
Nature moisturizing factor in the present invention can be combined by the moisture in cell, reduce the evaporation of moisture in cell, strengthen the moisture-keeping functions of skin, ceramide then effectively can block nature moisturizing factor, prevent the loss of nature moisturizing factor, the intracellular moisture of further pinning, reduces the loss of ICW, can extend the moisture preserving time of this moisture-keeping composition.
In addition, present invention also offers a kind of preparation method of moisture-keeping composition, comprise the following steps:
Phospholipid, cholesterol, emulsifying agent and antioxidant add in ethanol and dissolve by S1, then add water, fully stir and homogenizing, obtain I phase in 30-40 DEG C;
Herba Dendrobii extract and Semen Vitis viniferae extract are dissolved in phosphate buffer by S2, and mix homogeneously obtains II phase;
What step S1 obtained by S3 I is added in II phase that step S2 obtains, and stirs, filters, obtain filtrate, by filtrate through ultrasonic Treatment, be separated to obtain plant extract composite lipidosome;
The plant extract composite lipidosome that step S3 obtains by S4 adds mix and blend in Herba Dendrobii extract, Aloe extract, nature moisturizing factor and ceramide, homogenizing, obtains mixed liquor;
The mixed liquor that step S4 obtains by S5 carries out lyophilization, obtains moisture-keeping composition powder.
In addition, present invention also offers moisture-keeping composition and prepare the purposes in moisture-keeping cosmetics.When using this moisture-keeping composition, directly add in multiple formulations system with the addition of 1-10%, as toner/smoothing toner, emulsion, cream and facial film etc., make corresponding moisture retention water, moisturizing emulsion, moisturizing cream and moisture saver mask etc.
In a word, moisture-keeping composition provided by the invention, compared with prior art has following advantage:
1) moisture-keeping composition provided by the invention utilizes liposome technology, Herba Dendrobii extract and Semen Vitis viniferae extract are wrapped in liposome, Herba Dendrobii extract and Semen Vitis viniferae extract can be made to arrive in skin corium, repair stromal cell, promote the synthesis of collagen protein, elastin laminin and mucopolysaccharide, improve the Nomenclature Composition and Structure of Complexes of skin corium substrate, thus reach the effect of deep water supplement and maintenance skin corium, can fundamentally solve xerodermatic problem.
2) the Herba Dendrobii extract in moisture-keeping composition provided by the invention and Aloe extract; supplementary skin moisture can be continued; strengthen elasticity and the plumpness of skin; and it can also form protective barrier at skin surface; prevent water loss; the moisture preserving time of further this moisture-keeping composition of prolongation, strengthens moistening effect.
3) the Herba Dendrobii extract in moisture-keeping composition provided by the invention and Aloe extract also have antiinflammatory, antibacterial effect at horny layer, have a better role to acne, inflammatory skin and coarse skin tool.
Accompanying drawing explanation
Fig. 1 is short-term moistening effect result of the test figure of the present invention;
Fig. 2 is skin improvement effects Experimental Comparison figure of the present invention.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.Each component of the present invention is conventional commercial product, such as, Herba Dendrobii extract is purchased from Luo Jie bio tech ltd, Guangzhou, article No. is s1001101, Semen Vitis viniferae extract is purchased from Spain plimon, article No. is 00837001, and Aloe extract is purchased from Yu Zhi biochemical technology limited company, and article No. is YP-M90702001.
embodiment 1,moisture-keeping composition
Described moisture-keeping composition comprises following component and parts by weight thereof:
Plant extract composite lipidosome 10kg, Herba Dendrobii extract 3kg, Aloe extract 3kg, described plant extract composite lipidosome comprises the Herba Dendrobii extract and Semen Vitis viniferae extract that weight ratio is 1:0.5.
Its preparation method comprises the following steps:
0.5kg phospholipid, 0.5kg cholesterol, 1kg are mixed the emulsifying agent that forms and 1kg tocopherol acetas by Tween 80, glycolic acid and sodium cholate and add in 5kg ethanol and dissolve, then add 3kg water by S1, fully stir and homogenizing, obtain I phase in 30 DEG C;
1kg Herba Dendrobii extract and 0.5kg Semen Vitis viniferae extract are dissolved in phosphate buffer by S2, and mix homogeneously obtains II phase;
What step S1 obtained by S3 I is added in II phase that step S2 obtains, and stirs, through 5um membrane filtration, by filtrate through ultrasonic Treatment, is separated to obtain plant extract composite lipidosome;
S4 adds the plant extract composite lipidosome and 3kg Herba Dendrobii extract, 3kg Aloe extract mix and blend that 10kg step S3 obtains, and homogenizing, obtains mixed liquor;
The mixed liquor that step S4 obtains by S5, in-20 DEG C of pre-cooling 12h, under being less than the environment of 0.1MPa, at-20 DEG C of freezing 10h, then at-10 DEG C of freezing 8h, at-4 DEG C of freezing 5h, finally at 25 DEG C of process 2h, obtains moisture-keeping composition powder in cold vacuum.
embodiment 2,moisture-keeping composition
Described moisture-keeping composition comprises following component and parts by weight thereof:
Plant extract composite lipidosome 15kg, Herba Dendrobii extract 5kg, Aloe extract 5kg, sodium lactate 1kg and ceramide 0.5kg, described plant extract composite lipidosome comprises the Herba Dendrobii extract and Semen Vitis viniferae extract that weight ratio is 3:1.
Its preparation method comprises the following steps:
0.5kg phospholipid, 0.5kg cholesterol, 1kg are mixed the emulsifying agent that forms and 1kg tocopherol acetas by Tween 80, glycolic acid and sodium cholate and add in 5kg ethanol and dissolve, then add 3kg water by S1, fully stir and homogenizing, obtain I phase in 35 DEG C;
3kg Herba Dendrobii extract and 1kg Semen Vitis viniferae extract are dissolved in phosphate buffer by S2, and mix homogeneously obtains II phase;
What step S1 obtained by S3 I is added in II phase that step S2 obtains, and stirs, through 5um membrane filtration, by filtrate through ultrasonic Treatment, is separated to obtain plant extract composite lipidosome;
S4 adds the plant extract composite lipidosome and 5kg Herba Dendrobii extract, 5kg Aloe extract, 1kg sodium lactate and 0.5kg ceramide mix and blend that 15kg step S3 obtains, and homogenizing, obtains mixed liquor;
The mixed liquor that step S4 obtains by S5, in-20 DEG C of pre-cooling 12h, under being less than the environment of 0.1MPa, at-20 DEG C of freezing 10h, then at-10 DEG C of freezing 8h, at-4 DEG C of freezing 5h, finally at 25 DEG C of process 2h, obtains moisture-keeping composition powder in cold vacuum.
embodiment 3,moisture-keeping composition
Described moisture-keeping composition comprises following component and parts by weight thereof:
Plant extract composite lipidosome 25kg, Herba Dendrobii extract 10kg, Aloe extract 10kg, glucosamine 2kg and Cer EOS kg, described plant extract composite lipidosome comprises the Herba Dendrobii extract and Semen Vitis viniferae extract that weight ratio is 5:3.
Its preparation method comprises the following steps:
0.5kg phospholipid, 0.5kg cholesterol, 1kg are mixed the emulsifying agent that forms and 1kg tocopherol acetas by Tween 80, glycolic acid and sodium cholate and add in 5kg ethanol and dissolve, then add 3kg water by S1, fully stir and homogenizing, obtain I phase in 40 DEG C;
5kg Herba Dendrobii extract and 3kg Semen Vitis viniferae extract are dissolved in phosphate buffer by S2, and mix homogeneously obtains II phase;
What step S1 obtained by S3 I is added in II phase that step S2 obtains, and stirs, through 5um membrane filtration, by filtrate through ultrasonic Treatment, is separated to obtain plant extract composite lipidosome;
S4 adds the plant extract composite lipidosome and 10kg Herba Dendrobii extract, 10kg Aloe extract, 2kg glucosamine and 1kg ceramide mix and blend that 25kg step S3 obtains, and homogenizing, obtains mixed liquor;
The mixed liquor that step S4 obtains by S5, in-20 DEG C of pre-cooling 12h, under being less than the environment of 0.1MPa, at-20 DEG C of freezing 10h, then at-10 DEG C of freezing 8h, at-4 DEG C of freezing 5h, finally at 25 DEG C of process 2h, obtains moisture-keeping composition powder in cold vacuum.
test example one,skin moisture-keeping is tested
1, subjects: the mice choosing 40 12-13 all ages, Nanjing Experimental Animal Center provides.
2, test material: moisture-keeping composition prepared by the moisture-keeping composition of commercially available emulsion, embodiment 1 preparation, embodiment 2 and moisture-keeping composition prepared by embodiment 3.
3, test method: 40 mice shavers are shaved off back by hair, exposes the skin that size is about 2cm × 3cm, is then divided into 4 groups at random, is respectively blank group, embodiment 1 group, embodiment 2 groups and embodiment 3 groups, often organize 10.Each group of mice is handled as follows:
Commercially available emulsion group: the baring skin commercially available emulsion being applied to mouse back;
Embodiment 1 group: the baring skin commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 1 being applied to mouse back;
Embodiment 2 groups: the baring skin commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 2 being applied to mouse back;
Embodiment 3 groups: the baring skin commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 3 being applied to mouse back.
Expose under mice after having smeared emulsion is placed in dehumidifier environment, expose 12 hours every day, continue 25 days; Then carry out the moisture determination of mouse back baring skin, take off the rear skin histology 0.5g of depilation with card punch, accurate title skin weight in wet base, places 48h in 80 DEG C of drying baker, claims skin dry weight.And measure the skin percentage of moisture by following formula: the skin percentage of moisture=(skin weight in wet base-dry weight)/weight in wet base × 100%.
4, result of the test:
Result of the test is as shown in table 1.
The test data of table 1 mouse skin water content
| Group | The skin percentage of moisture |
| Commercially available emulsion group | 35.24% |
| Embodiment 1 group | 68.56% |
| Embodiment 2 groups | 72.38% |
| Embodiment 3 groups | 69.42% |
As shown in Table 1, using the average percentage of moisture of the mouse skin being added with the emulsion of moisture-keeping composition prepared by the present invention than using the mouse skin percentage of moisture of commercially available emulsion to improve 34.88%, illustrating that the present invention prepares moisture-keeping composition and has good replenishing water and preserving moisture effect.
test example two,short-term moistening effect is tested
1, subjects: select 15 experimenters, age 20-35 year.
2, test material: the moisture-keeping composition of commercially available toner/smoothing toner, commercially available moisturizing ingredient, embodiment 2 preparation.
3, test method: 15 experimenters are divided into 3 groups at random, often organize 5 people, be respectively matched group, test 1 group and test 2 groups, under constant temperature and humidity condition, temperature is 20 ± 1 DEG C, humidity 50 ± 2%.The coating method of each group of experimenter is as follows:
Matched group: commercially available toner/smoothing toner is evenly applied in the left arm of experimenter;
Test 1 group: be evenly applied in the left arm of experimenter by the commercially available toner/smoothing toner being added with 5% commercially available moisturizing ingredient;
Test 2 groups: be evenly applied in the left arm of experimenter by the commercially available toner/smoothing toner being added with moisture-keeping composition prepared by 5% embodiment 2.
Measure the change of keratodermatitis water content after 20min, 2h, 4h and 6h respectively with CorneometerCM825 after coating.
4, result of the test:
Result of the test as shown in Figure 1, in figure compared with matched group, * p < 0.05, * * p < 0.01.As shown in Figure 1:
1) matched group, after using commercially available toner/smoothing toner, the cuticular instantaneous water content of experimenter increases, but cuticular instantaneous water content returns to the level before use very soon, illustrates that the moistening effect of commercially available toner/smoothing toner is poor.
2) compared with matched group, test the horny layer of 1 group of experimenter after 20 min, the increase of instantaneous water content has extremely significant difference (p < 0.01), but instantaneous water content starts to decline after 2h, instantaneous water content to skin during 4h returns to the level before use, illustrate that the commercially available toner/smoothing toner being added with 5% commercially available moisturizing ingredient has good moisturizing effect at short notice, but moistening effect persistence is poor.
3) compared with matched group, test the horny layer of 2 groups of experimenters in 6h, the increase of instantaneous water content has extremely significant difference (p < 0.01), although instantaneous water content slightly reduces after using 2h, but cuticular instantaneous water content is still in higher level, until water content levels when cuticular water content still remains on 2h after 6h, have no reduction, the commercially available toner/smoothing toner moisturizing Be very effective being added with moisture-keeping composition prepared by 5% embodiment 2 is described, and moistening effect persistence is good, it is a kind of desirable moisturizing ingredient.
test example three,skin improvement effects is tested
1, subjects: choosing 6 skin types is the female subjects of dry skin, the age is 20-30 year.
2, test material: the commercially available emulsion of moisture-keeping composition prepared by commercially available emulsion, 5% embodiment 2 of adding.
3, test method: the left face commercially available soft emulsion being applied to experimenter, is applied to the right face of experimenter simultaneously by the commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 2, sooner or later once, use 4 weeks continuously.Dermal imaging tester DermaVision-Pro high-definition camera is used to take the photo using face before and after product.
4, result of the test
Result of the test as shown in Figure 2, wherein A face uses commercially available emulsion, B face uses the commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 2, find through contrast, continuous use is after 4 weeks, use the experimenter of the commercially available emulsion being added with moisture-keeping composition prepared by 5% embodiment 2, its eye part skin brightness increase, fuller, the dry stricture of vagina of skin greatly reduce, illustrate that moisture-keeping composition prepared by the present invention has significant moistening effect, and life-time service can significantly improve skin situation, skin water is moistened, fine and smooth, glossy.
Claims (9)
1. a moisture-keeping composition, is characterized in that, comprises following component and parts by weight thereof:
Plant extract composite lipidosome 10-25 part, Herba Dendrobii extract 3-10 part, Aloe extract 3-10 part, nature moisturizing factor 0-3 part and ceramide 0-3 part.
2. moisture-keeping composition as claimed in claim 1, is characterized in that, comprise following component and parts by weight thereof:
Plant extract composite lipidosome 15 parts, Herba Dendrobii extract 5 parts, Aloe extract 5 parts, nature moisturizing factor 1 part and ceramide 0.5 part.
3. moisture-keeping composition as claimed in claim 1 or 2, it is characterized in that, described plant extract is Herba Dendrobii extract and Semen Vitis viniferae extract.
4. moisture-keeping composition as claimed in claim 3, it is characterized in that, in described plant extract, the weight ratio of Herba Dendrobii extract and Semen Vitis viniferae extract is 1-5:0.5-3.
5. moisture-keeping composition as claimed in claim 4, it is characterized in that, in described plant extract, the weight ratio of Herba Dendrobii extract and Semen Vitis viniferae extract is 3:1.
6. moisture-keeping composition as claimed in claim 1 or 2, is characterized in that, described nature moisturizing factor is one in glucosamine and sodium lactate or its compositions.
7. a preparation method for the moisture-keeping composition as described in as arbitrary in claim 1-6, is characterized in that, comprise the following steps:
Phospholipid, cholesterol, emulsifying agent and antioxidant add in ethanol and dissolve by S1, then add water, fully stir and homogenizing, obtain I phase in 30-40 DEG C;
Herba Dendrobii extract and Semen Vitis viniferae extract are dissolved in phosphate buffer by S2, and mix homogeneously obtains II phase;
What step S1 obtained by S3 I is added in II phase that step S2 obtains, and stirs, filters, obtain filtrate, by filtrate through ultrasonic Treatment, be separated to obtain plant extract composite lipidosome;
The plant extract composite lipidosome that step S3 obtains by S4 adds mix and blend in Herba Dendrobii extract, Aloe extract, nature moisturizing factor and ceramide, homogenizing, obtains mixed liquor;
The mixed liquor that step S4 obtains by S5 carries out lyophilization, obtains moisture-keeping composition powder.
8. the moisture-keeping composition as described in as arbitrary in claim 1-6 is preparing the purposes in moisture-keeping cosmetics.
9. purposes as claimed in claim 8, it is characterized in that, the addition of described moisture-keeping composition is 1-10%.
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| CN105997609A (en) * | 2016-05-11 | 2016-10-12 | 广东科玮生物技术股份有限公司 | Moisture preserving composition and preparation method thereof |
| CN107157872A (en) * | 2017-05-08 | 2017-09-15 | 宁波易中禾生物技术有限公司 | A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof |
| CN108295002A (en) * | 2017-01-11 | 2018-07-20 | 伽蓝（集团）股份有限公司 | Application of the snowflake water extract in regulating and controlling Period of Fibroblast |
| CN112043632A (en) * | 2020-08-19 | 2020-12-08 | 上海中翊日化有限公司 | Application of grape seed extract double inclusion |
| CN112245340A (en) * | 2020-07-26 | 2021-01-22 | 广州元美盛化妆品有限公司 | Natural milk-flavored cosmetic with core-shell structure and preparation method thereof |
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| CN104814902A (en) * | 2015-05-18 | 2015-08-05 | 胡红慧 | Plant moisturizing composition |
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| CN102274138A (en) * | 2010-06-11 | 2011-12-14 | 上海家化联合股份有限公司 | Dendrobe extract and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105997609A (en) * | 2016-05-11 | 2016-10-12 | 广东科玮生物技术股份有限公司 | Moisture preserving composition and preparation method thereof |
| CN108295002A (en) * | 2017-01-11 | 2018-07-20 | 伽蓝（集团）股份有限公司 | Application of the snowflake water extract in regulating and controlling Period of Fibroblast |
| CN107157872A (en) * | 2017-05-08 | 2017-09-15 | 宁波易中禾生物技术有限公司 | A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof |
| CN107157872B (en) * | 2017-05-08 | 2019-11-22 | 宁波易中禾生物技术有限公司 | A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof |
| CN112245340A (en) * | 2020-07-26 | 2021-01-22 | 广州元美盛化妆品有限公司 | Natural milk-flavored cosmetic with core-shell structure and preparation method thereof |
| CN112043632A (en) * | 2020-08-19 | 2020-12-08 | 上海中翊日化有限公司 | Application of grape seed extract double inclusion |
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| CN105125435B (en) | 2018-04-24 |
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Denomination of invention: Moisturizing composition as well as preparation method and application thereof Effective date of registration: 20191226 Granted publication date: 20180424 Pledgee: China Co truction Bank Corp Guangzhou green finance reform and innovation pilot area Huadu Branch Pledgor: GUANGDONG ESSENCE BIOTECHNOLOGY CO., LTD. Registration number: Y2019440000320 |