CN109172404A - A kind of anti-wrinkle essence and preparation method thereof - Google Patents
A kind of anti-wrinkle essence and preparation method thereof Download PDFInfo
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- CN109172404A CN109172404A CN201811217167.8A CN201811217167A CN109172404A CN 109172404 A CN109172404 A CN 109172404A CN 201811217167 A CN201811217167 A CN 201811217167A CN 109172404 A CN109172404 A CN 109172404A
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- 230000001976 improved effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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Abstract
The invention proposes a kind of anti-wrinkle essences, are prepared by weight by following raw material: 50-70 parts of jewfish Isin glue collagen peptide, 35-45 parts of modified collagen albumen, 20-35 parts of tremella polysaccharides, 40-60 parts of aloe polysaccharide, 10-22 parts of honey, Chinese medicine is liquid 5-15 parts crease-resistant, 1-5 parts of antioxidant, 10-25 parts of Chinese medicine ultraviolet absorber, 1-2 parts of butanediol, 1-5 parts of polyethylene glycol 400,2-7 parts of glycerol, 5-10 parts of plants essential oil, 0.1-1 parts of EDTA2Na, 1-2 parts of Bis(hydroxymethyl)imidazolidinyl urea, 2-4 parts of emulsifier and 100-120 parts of deionized water.The each component that the present invention adds is pure natural non-stimulated, reduces the addition of a large amount of synthesis compound, and is free of heavy metal, and crease-resistant, wrinkle improvement effect is obviously and lasting, and to skin-safe, raw material sources are wide, low in cost, is widely used.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of anti-wrinkle essence.
Background technique
Puberty is people's most pretty beautiful period in life, at this time skin slip, gloss, plentiful, high resilience, Bai Li
It is thoroughly red.To after 25 years old, metabolism starts to slow down, and moisture and subcutaneous fat are reduced, and elastomer is gradually thicker, and skin becomes
Wrinkle, gloss subside.After 40 years old, hormone in vivo dysequilibrium, keratin reduce, elastic fibers break, cutis laxa, it is coarse,
Wrinkle increases, and progresses into aging period.Skin aging is the outstanding behaviours of entire body aging, and wherein facial skin aging is especially
Obviously, fibroblastic quantity gradually decreases in human body, and the collagen and elastic fibers albumen of secretion are also because by oxygen
Change gradually decrease, be broken, just disappear to the supporting role of epidermis, cause it is inhomogenous collapse, skin corium starts thinning, skin bullet
Property be deteriorated, wrinkle also starts gradually to generate.
After wrinkle is the influence due to human body by endogenous and extrinsic factor, lead to skin support tissue and skin knot
The variation of structure, causes the forfeiture of skin moisturizing ability, thus the variation that elastic fibers and collagen put in order leads to the machine of skin
Tool power and flexibility decrease form recess, to form wrinkle.The mechanism that wrinkle generates is sufficiently complex, one of them is exactly to include
Cellular damage caused by each factor including ultraviolet light and by the increased Apoptosis of the damage, protease such as matrix metal egg
The hydrolysis of fibre composition such as collagen caused by the increase of white enzyme (matrix metalloprotease, MMPs) expression, and
Fibre bundle caused by the increase of cell factor is disintegrated.Wherein MMPs plays critical effect in this process, and it has
Multiple functions, such as degrade by collagen, proteoglycan, the extracellular matrix of elastin laminin formation and degradation in cell surface
The protein etc. of upper expression.And these degradations lead to the reduction and denaturation of extracellular matrix, are that skin forms wrinkle, relaxation
Deng key factor.In addition, since inflammation causes the inflammatory cytokines such as TNF-α, IL-1 and the IL-6 of cell generation that can pass through
The generation for inducing MMPs leads to the formation of wrinkle of skin and relaxation.
Although skin aging is irreversible physiological phenomenon, its process can delay or slow down.For face wrinkles,
Common anti-wrinkle method is operation smoothing wrinkle, injection anti-wrinkle and anti-wrinkle cosmetic.The treatment cost height of smoothing wrinkle of performing the operation and injection anti-wrinkle,
Risk is big, is not that each consumer can bear, and anti-wrinkle cosmetic is a selection well.Anti-wrinkle cosmetic is again
Be divided into anti-wrinkle face mask, mildy wash, crease-resistant toner, face cream, Essence etc. are a variety of, anti-wrinkle face mask, mildy wash face stop
Time is short, and effect is unobvious, needs to be used for a long time, and use process is also inconvenient；Active constituent in crease-resistant toner, face cream
Content is relatively low, and anti-wrinkle effect is also unobvious, and nutriment and active constituent that Essence contains are compared with toner, face cream
Want high more, effect is powerful, and anti-wrinkle effect is significant, but current Essence commonly has poor permeability, is not easy to absorb
Problem, and anti-wrinkle effect need to be improved.
Therefore, it is necessary to research and develop its a kind of good penetrability, easily absorb, effective replenishing water and preserving moisture, repair wrinkle of skin, inhibits wrinkle
Line regeneration, delay skin aging anti-wrinkle essence.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of anti-wrinkle essence and preparation method thereof, and purpose exists
In providing a kind of anti-wrinkle essence, by adding poly ethyldiol modified collagen, enhance the water solubility and life of collagen
Compatibility is managed, the absorption of cell after promoting on coated by collagen to skin enhances fold skin collagen content, to reach
Anti-wrinkle purpose；The another jewfish Isin glue collagen peptide that is added is coated to studies have shown that such protein peptides can promote cell Proliferation
Cells of superficial layer can be promoted to be proliferated after skin surface, to substitute damaged cell and aged cells, to further improve crease-resistant function
Energy.
The present invention provides a kind of anti-wrinkle essence, is prepared by weight by following raw material: jewfish Isin glue collagen peptide
50-70 parts, 35-45 parts of modified collagen albumen, 20-35 parts of tremella polysaccharides, 40-60 parts of aloe polysaccharide, 10-22 parts of honey, Chinese medicine
Crease-resistant liquid 5-15 parts, 1-5 parts of antioxidant, 10-25 parts of Chinese medicine ultraviolet absorber, 1-2 parts of butanediol, 1-5 parts of polyethylene glycol 400,
2-7 parts of glycerol, 5-10 parts of plants essential oil, 0.1-1 parts of EDTA2Na, 1-2 parts of Bis(hydroxymethyl)imidazolidinyl urea, emulsifier 2-
4 parts and deionized water 100-120 parts；
The modified collagen albumen is prepared by following methods: it weighs 2g collagen and is added in 100mL deionized water, 50 DEG C
30min is dissolved in water-bath, and suction filtration obtains pure collagen solution, separately weighs 2g polyethylene glycol, and 100mL volume fraction is added and is
In 2% glacial acetic acid, 30min is dissolved in 50 DEG C of stirred in water bath, by collagen and polyglycol solution according to l:2 mass
Than mixing, and the glycerol that mass fraction is 25% is added and makees plasticizer, stirring 10min is mixed under the conditions of 20 DEG C, in 65 DEG C of water
It is crosslinked 2h in bath to obtain the final product.
As further improvement of the invention, it is prepared by weight by following raw material: jewfish Isin glue collagen peptide 60
Part, 40 parts of modified collagen albumen, 27 parts of tremella polysaccharides, 50 parts of aloe polysaccharide, 18 parts of honey, 10 parts of the crease-resistant liquid of Chinese medicine, antioxidant 3
Part, 19 parts of Chinese medicine ultraviolet absorber, 1.5 parts of butanediol, 3 parts of polyethylene glycol 400,6 parts of glycerol, 7 parts of plants essential oil, EDTA
0.5 part of 2Na, 1.5 parts of Bis(hydroxymethyl)imidazolidinyl urea, 3 parts of emulsifier and 110 parts of deionized water.
As further improvement of the invention, the antioxidant is selected from 2,6- three-level butyl -4- methylphenol, bis- (3,5-
Three-level butyl -4- hydroxy phenyl) it is thioether, four (β-(3,5- three-level butyl -4- hydroxy phenyl) propionic acid) pentaerythritol esters, three pungent
Ester, three last of the ten Heavenly stems esters, three (Lauryl Alcohol) esters, three (16 carbon alcohol) esters, potassium sorbate, sorbic acid, sodium lactate, white reed alcohol, tea are more
One or more of phenol and vitamin C.
As further improvement of the invention, the Chinese medicine ultraviolet absorber is prepared by weight by following raw material:
27 parts of sophora flower, 20 parts of Radix Astragali, 15 parts of semen coicis, 15 parts of polygonum cuspidate, 13 parts of the coptis, 10 parts of bitter buckwheat, 7 parts of sweet basil, 5 parts of tsaoko and the sophora bud
2 parts.
As further improvement of the invention, the Chinese medicine ultraviolet absorber is prepared by following methods: being claimed in proportion
Sophora flower, Radix Astragali, semen coicis, polygonum cuspidate, the coptis, bitter buckwheat, sweet basil, tsaoko and the sophora bud are taken, is crushed after drying, is added according to solid-to-liquid ratio 1:20
Enter deionized water, after impregnating for 24 hours, after 500W microwave heating to 100 DEG C of reflux 5h, filtrate is collected in filtering；Filter residue is according to weight ratio
Deionized water is added in 1:1, and after the stagnant 100 DEG C of reflux 2h of 500W microwave heating, filtrate is collected in filtering, and merging filtrate twice is concentrated into
Density is 1.5-2g/cm3To get Chinese medicine ultraviolet absorber.
As further improvement of the invention, the crease-resistant liquid of Chinese medicine is prepared by weight by following raw material: crape myrtle
10 parts, 10 parts of rhizoma polygonati, 10 parts of fructus lycii, 10 parts of Radix Salviae Miltiorrhizae and 10 parts of tripterygium wilfordii.
As further improvement of the invention, the crease-resistant liquid of Chinese medicine is prepared by following methods: weighing purple in proportion
Common vetch, rhizoma polygonati, fructus lycii, Radix Salviae Miltiorrhizae and tripterygium wilfordii crush after drying, and it is 1:1's that ethyl alcohol-butanone volume ratio, which is added, according to solid-to-liquid ratio 1:10
Mixed solvent is heated to 50 DEG C after impregnating 2h, and 5-7h, filtering are extracted in 200r/min stirring, and revolving removes solvent, and it is anti-to obtain Chinese medicine
Wrinkle liquid.
As further improvement of the invention, the plants essential oil is selected from lavender oil, lemon oil, bergamot oil, cloves
One or more of oil, peppermint oil, cinnamon oil, attar of rose.
As further improvement of the invention, the emulsifier is selected from odium stearate, potassium stearate, sodium palmitate, palm
One or more of sour potassium, lauryl sodium sulfate, twain series emulsifier and Span series emulsifier, the TWEEN Series
Emulsifier includes but are not limited to Tween-20, Tween-40, Tween-60, Tween-80；The Span series emulsifier include but
It is not limited only to Arlacel-20, Arlacel-40, Arlacel-60, Arlacel-80.
The present invention further protects a kind of preparation method of above-mentioned anti-wrinkle essence, is prepared according to the following steps:
(1) tremella polysaccharides, aloe polysaccharide, honey, polyethylene glycol 400, glycerol and EDTA2Na are added in reactor,
1/2 deionized water is added, is heated to 70 DEG C, stirring 30min dissolution completely, obtains A liquid；
(2) by jewfish Isin glue collagen peptide, modified collagen albumen, the crease-resistant liquid of Chinese medicine, antioxidant, Chinese medicine ultraviolet absorber and
Butanediol is added to the container, and is added 1/4 deionized water, heating stirring 20min to being completely dissolved, temperature control 75 DEG C with
Under, obtain B liquid；
(3) under constant stirring, slowly B liquid is added in A liquid, emulsifier is added, keep 70 DEG C of fast homogeneous stirring 2-3
Minute, make into lotion, continuously add Bis(hydroxymethyl)imidazolidinyl urea, butanediol and plants essential oil, continues to stir evenly, it is cooling
To room temperature, bottling obtains anti-wrinkle essence.
The invention has the following beneficial effects:
1. the present invention enhances the water solubility and PHYSIOLOGICALLY COMPATIBLE of collagen by adding poly ethyldiol modified collagen
Property, the absorption of cell after promoting on coated by collagen to skin enhances fold skin collagen content, to reach anti-wrinkle
Purpose；
2. jewfish Isin glue collagen peptide is added in the present invention, studies have shown that such protein peptides can promote cell Proliferation, coating
Cells of superficial layer can be promoted to be proliferated after to skin surface, to substitute damaged cell and aged cells, to further improve crease-resistant
Function；
3. the present invention, by the way that tremella polysaccharides, aloe polysaccharide, honey and glycerol is added, this few class raw material synergistic effect plays very
Good skin moisture-keeping effect, the cell of hyperplasia will not be damaged because of dehydration and again, to keep cell viability；
4. the present invention is also added into the crease-resistant liquid of Chinese medicine and Chinese medicine ultraviolet absorber, these two types of Chinese medical extracts can obviously change
Kind wrinkle and absorption ultraviolet light, avoid UV on skin cells of superficial layer, reduce by the increased Apoptosis of the damage, albumen
Skin is protected in the hydrolysis of enzyme fibre composition as caused by the increase of Expression of Matrix Metalloproteinases such as collagen；
5. natural plant essential oils are added in the present invention, increase the fragrance of product, it is pure natural non-stimulated, and taste is soft pure and fresh,
Liked by the majority of consumers；
6. each component that the present invention adds is pure natural non-stimulated, reduce the addition of a large amount of synthesis compound, and not
Containing heavy metal, crease-resistant, wrinkle improvement effect is obviously and lasting, and to skin-safe, raw material sources are wide, low in cost, therefore, using wide
It is general.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, the embodiment described is the embodiment of part of representative of the invention, rather than whole embodiments, this field are general
Other all embodiments obtained belong to protection of the invention to logical technical staff without making creative work
Range.
The preparation of 1 modified collagen albumen of embodiment
It is prepared by following methods: weighing 2g collagen and be added in 100mL deionized water, 30min is dissolved in 50 DEG C of water-baths, takes out
Filter obtains pure collagen solution, separately weighs 2g polyethylene glycol, is added in the glacial acetic acid that 100mL volume fraction is 2%, in
50 DEG C of stirred in water bath dissolves 30min, collagen is mixed with polyglycol solution according to l:2 mass ratio, and matter is added
The glycerol that amount score is 25% makees plasticizer, and stirring 10min is mixed under the conditions of 20 DEG C, and 2h is crosslinked in 65 DEG C of water-bath and is changed to obtain the final product
Property collagen, yield 92%.
The preparation of 2 modified collagen albumen of embodiment
It is prepared by following methods: weighing 2g collagen and be added in 100mL deionized water, 30min is dissolved in 50 DEG C of water-baths, takes out
Filter obtains pure collagen solution, separately weighs 2g polyethylene glycol, is added in the glacial acetic acid that 100mL volume fraction is 5%, in
50 DEG C of stirred in water bath dissolves 30min, collagen is mixed with polyglycol solution according to l:5 mass ratio, and matter is added
The glycerol that amount score is 25% makees plasticizer, and stirring 10min is mixed under the conditions of 20 DEG C, and 2h is crosslinked in 80 DEG C of water-bath and is changed to obtain the final product
Property collagen, yield 72%.
The preparation of 3 Chinese medicine ultraviolet absorber of embodiment
It is prepared by weight by following raw material: 27 parts of sophora flower, 20 parts of Radix Astragali, 15 parts of semen coicis, 15 parts of polygonum cuspidate, the coptis
13 parts, 10 parts of bitter buckwheat, 7 parts of sweet basil, 5 parts of tsaoko and 2 parts of the sophora bud；
Prepared by following methods: weigh in proportion sophora flower, Radix Astragali, semen coicis, polygonum cuspidate, the coptis, bitter buckwheat, sweet basil, tsaoko and
The sophora bud crushes after drying, and deionized water is added according to solid-to-liquid ratio 1:20, after impregnating for 24 hours, 500W microwave heating to 100 DEG C of reflux
After 5h, filtrate is collected in filtering；Deionized water is added according to weight ratio 1:1 in filter residue, after the stagnant 100 DEG C of reflux 2h of 500W microwave heating,
Filtrate is collected in filtering, merges filtrate twice, and being concentrated into density is 1.8g/cm3To get Chinese medicine ultraviolet absorber, yield is
90%.
The preparation of 4 Chinese medicine ultraviolet absorber of embodiment
It is prepared by weight by following raw material: 27 parts of sophora flower, 20 parts of Radix Astragali, 15 parts of semen coicis, 15 parts of polygonum cuspidate, the coptis
13 parts, 10 parts of bitter buckwheat, 7 parts of sweet basil, 5 parts of tsaoko and 2 parts of the sophora bud；
Prepared by following methods: weigh in proportion sophora flower, Radix Astragali, semen coicis, polygonum cuspidate, the coptis, bitter buckwheat, sweet basil, tsaoko and
The sophora bud crushes after drying, and deionized water is added according to solid-to-liquid ratio 1:20, after impregnating for 24 hours, electric jacket is heated to 100 DEG C of reflux 5h
Afterwards, it filters, collects filtrate；Deionized water is added according to weight ratio 1:1 in filter residue, after the stagnant 100 DEG C of reflux for 24 hours of electric jacket heating, mistake
Filtrate is collected in filter, merges filtrate twice, and being concentrated into density is 1.8g/cm3To get Chinese medicine ultraviolet absorber, yield 80%.
The preparation of the crease-resistant liquid of 5 Chinese medicine of embodiment
It is prepared by weight by following raw material: 10 parts of crape myrtle, 10 parts of rhizoma polygonati, 10 parts of fructus lycii, 10 parts of Radix Salviae Miltiorrhizae and Thunder God
10 parts of rattan；
It is prepared by following methods: weighing crape myrtle, rhizoma polygonati, fructus lycii, Radix Salviae Miltiorrhizae and tripterygium wilfordii in proportion, crushed after drying, according to
The mixed solvent that ethyl alcohol-butanone volume ratio is 1:1 is added in solid-to-liquid ratio 1:10, is heated to 50 DEG C after impregnating 2h, 200r/min stirring
5-7h, filtering are extracted, revolving removes solvent, obtains the crease-resistant liquid of Chinese medicine, yield 95%.
The preparation of the crease-resistant liquid of 6 Chinese medicine of embodiment
It is prepared by weight by following raw material: 15 parts of crape myrtle, 5 parts of rhizoma polygonati, 7 parts of fructus lycii, 2 parts of Radix Salviae Miltiorrhizae and tripterygium wilfordii 20
Part；
It is prepared by following methods: weighing crape myrtle, rhizoma polygonati, fructus lycii, Radix Salviae Miltiorrhizae and tripterygium wilfordii in proportion, crushed after drying, according to
The mixed solvent that ethyl alcohol-butanone volume ratio is 1:1 is added in solid-to-liquid ratio 1:10, is heated to 50 DEG C after impregnating 2h, 200r/min stirring
5-7h, filtering are extracted, revolving removes solvent, obtains the crease-resistant liquid of Chinese medicine, yield 83%.
The preparation of 7 anti-wrinkle essence of embodiment
It is prepared by weight by following raw material: 50 parts of jewfish Isin glue collagen peptide, 35 parts of modified collagen albumen, tremella
20 parts of polysaccharide, 40 parts of aloe polysaccharide, 10 parts of honey, 5 parts of the crease-resistant liquid of Chinese medicine, 1 part of potassium sorbate, 10 parts of Chinese medicine ultraviolet absorber,
1 part of butanediol, 1 part of polyethylene glycol 400,2 parts of glycerol, 5 parts of peppermint oil, 0.1 part of EDTA2Na, bis- (methylol) imidazolidines
1 part of base urea, 2 parts of lauryl sodium sulfate and 100 parts of deionized water；
It is prepared by following methods:
(1) tremella polysaccharides, aloe polysaccharide, honey, polyethylene glycol 400, glycerol and EDTA2Na are added in reactor,
1/2 deionized water is added, is heated to 70 DEG C, stirring 30min dissolution completely, obtains A liquid；
(2) by jewfish Isin glue collagen peptide, modified collagen albumen, the crease-resistant liquid of Chinese medicine, potassium sorbate, Chinese medicine ultraviolet absorber
Be added to the container with butanediol, be added 1/4 deionized water, heating stirring 20min to being completely dissolved, temperature control 75 DEG C with
Under, obtain B liquid；
(3) under constant stirring, slowly B liquid is added in A liquid, lauryl sodium sulfate is added, 70 DEG C of holding is quickly equal
Matter stirs 2-3 minutes, makes into lotion, continuously adds Bis(hydroxymethyl)imidazolidinyl urea, butanediol and peppermint oil, and it is equal to continue stirring
It is even, it is cooled to room temperature, bottles, obtain anti-wrinkle essence.
The preparation of 7 anti-wrinkle essence of embodiment
It is prepared by weight by following raw material: 70 parts of jewfish Isin glue collagen peptide, 45 parts of modified collagen albumen, tremella
35 parts of polysaccharide, 60 parts of aloe polysaccharide, 22 parts of honey, 15 parts of the crease-resistant liquid of Chinese medicine, bis- (3,5- three-level butyl -4- hydroxy phenyl) thioethers
5 parts, 25 parts of Chinese medicine ultraviolet absorber, 2 parts of butanediol, 5 parts of polyethylene glycol 400,7 parts of glycerol, 10 parts of attar of rose, EDTA2Na
1 part, 2 parts of Bis(hydroxymethyl)imidazolidinyl urea, 4 parts of potassium palmitate and 120 parts of deionized water；
It is prepared by following methods:
(1) tremella polysaccharides, aloe polysaccharide, honey, polyethylene glycol 400, glycerol and EDTA2Na are added in reactor,
1/2 deionized water is added, is heated to 70 DEG C, stirring 30min dissolution completely, obtains A liquid；
(2) by jewfish Isin glue collagen peptide, modified collagen albumen, the crease-resistant liquid of Chinese medicine, bis- (3,5- three-level butyl -4- hydroxyls
Phenyl) thioether, Chinese medicine ultraviolet absorber and butanediol be added to the container, 1/4 deionized water is added, heating stirring 20min is extremely
It is completely dissolved, temperature control is at 75 DEG C hereinafter, obtaining B liquid；
(3) under constant stirring, slowly B liquid is added in A liquid, potassium palmitate is added, keep 70 DEG C of fast homogeneous stirrings
2-3 minutes, make into lotion, continuously add Bis(hydroxymethyl)imidazolidinyl urea, butanediol and attar of rose, continues to stir evenly, it is cold
But to room temperature, bottling obtains anti-wrinkle essence.
The preparation of 9 anti-wrinkle essence of embodiment
It is prepared by weight by following raw material: 60 parts of jewfish Isin glue collagen peptide, 40 parts of modified collagen albumen, tremella
27 parts of polysaccharide, 50 parts of aloe polysaccharide, 18 parts of honey, 10 parts of the crease-resistant liquid of Chinese medicine, 1 part of tea polyphenols, 3 parts of vitamin C, the ultraviolet suction of Chinese medicine
Receive 19 parts of agent, 1.5 parts of butanediol, 3 parts of polyethylene glycol 400,6 parts of glycerol, 7 parts of bergamot oil, EDTA2Na0.5 parts, bis- (hydroxyls
Methyl) 1.5 parts of imidazolidinyl urea, 2 parts of Tween-80,1 part of Arlacel-80 and 110 parts of deionized water；
It is prepared by following methods:
(1) tremella polysaccharides, aloe polysaccharide, honey, polyethylene glycol 400, glycerol and EDTA2Na are added in reactor,
1/2 deionized water is added, is heated to 70 DEG C, stirring 30min dissolution completely, obtains A liquid；
(2) jewfish Isin glue collagen peptide, modified collagen albumen, the crease-resistant liquid of Chinese medicine, tea polyphenols, vitamin C, Chinese medicine is ultraviolet
Absorbent and butanediol are added to the container, and 1/4 deionized water are added, to being completely dissolved, temperature control exists heating stirring 20min
75 DEG C hereinafter, obtain B liquid；
(3) under constant stirring, slowly B liquid is added in A liquid, Tween-80 and Arlacel-80 is added, 70 DEG C of holding is quickly
Homogeneous stirs 2-3 minutes, makes into lotion, continuously adds Bis(hydroxymethyl)imidazolidinyl urea, butanediol and bergamot oil, continues to stir
It mixes uniformly, is cooled to room temperature, bottle, obtain anti-wrinkle essence.
Reference examples 1 are according to patent ZL 201510731589.7 " a method of have effects that the Essence of skin wrinkle resisting "
Preparation
Functional component: 15 parts of cyperus alternifolius extract, 0.5 part of Roselle flower extract, 0.5 part of gumbo extract, fullerene
0.05 part, 6 parts of micromolecule hyaluronic acid；
Carrier: 2 parts of 1,3-BDO, 3 parts of glycerol, 0.5 part of Phenoxyethanol, 72.45 parts of deionized water；
By load weighted glycerol, 1,3-BDO, deionized water is added in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and ingredients such as Phenoxyethanol, it is filling up to having effects that crease-resistant Essence until stir evenly.
1 human skin patch of test example
1. tested material: anti-wrinkle essence prepared by embodiment 9
2. negative control: deionized water
3. subject: totally 30 people, male 0 people, 30 people of female the age 21-48 years old, meet subject and volunteer inclusion criteria.
4. patch method: selecting qualified spot tester, with enclosed patch test method, about by tested material and negative control
0.020mL-0.025mL (semifluid) is dripped in spot tester, and external application special adhesive tape is pasted on subject back, removes after 24 hours
Tested material, observation dermoreaction in 0.5,24,48 hour after removing respectively, by skin in " cosmetics health specification " (version in 2007)
Reaction grade scale records its result.Test result is shown in Table 1:
1 human skin patch test result of table
Human skin patch test result is shown: 0 there is skin adverse reaction in 30 people；Illustrate crease-resistant essence of the invention
Magnificent liquid uses safe.
The crease-resistant functional experiment of test example 2
Sample sets: anti-wrinkle essence prepared by embodiment 9；
Control group: prepared by reference examples 1 has effects that the Essence of skin wrinkle resisting
1, to the inhibiting rate of MMP-1 expression
The anti-wrinkle effect of these samples is assessed by testing these samples the inhibiting rate of MMP-1: by fibroblast
It is inoculated into 12 porocyte culture plates, each hole contains 0.75 × 105A cell, and the hungry culture in serum free medium
24 hours.The cell through starvation culture is rinsed with PBS, and with treatment with ultraviolet light (40mJ).Then, within 48 hours, to thin
It is added test sample 2 times in born of the same parents.With the MMP-1 separated in kit (BIOTRAK, RPN2610) measurement culture medium.Pass through calculating
The expression inhibiting rate of MMP-1 assesses the power of crease-resistant effect.Calculation formula is as follows:
Inhibiting rate=(A-B)/A*100%
A: being not added with test sample, but after ultraviolet irradiation MMP-1 expression quantity
B: addition test sample and after ultraviolet irradiation MMP-1 expression quantity
As a result shown in table 1.
The inhibiting rate that the different test samples of table 1 express MMP-1
| Group | Applying amount (mL) | Inhibiting rate (%) |
| Embodiment 9 | 1 | 80.1 |
| Reference examples 1 | 1 | 95.7 |
As seen from the above table, the anti-wrinkle essence that prepared by the embodiment of the present invention 9 has and preferably inhibits compared to reference examples 1
The expression effect of MMP-1.
2, the synthesis promotion rate of III collagen type:
The human fibroblasts cultivated in the DMEM culture medium containing 10%FBS are seeded in 24 orifice plates, after cell attachment,
Carry out culture medium exchange with the DMEM culture medium containing 0.25%FBS and 250 μM of magnesium ascorbyl phosphate, be separately added into it is above-mentioned to
Sample.After culture three days, culture medium supernatant is recycled, centrifuge separation measures III collagen type in gained supernatant.
Evaluation method about the biosynthesis ability of III collagen type in cell is using " III P (P of RIA-gnost P
III P) assay kit " terminal peptide (the Procollagen type III-of III collagen type that secretes in measurement supernatant
Peptide: referred to as III P of P) content.The crease-resistant of these samples is assessed by the synthesis promotion rate of III collagen type
The power of effect.Calculation formula is as follows:
Promotion rate=(A-B)/B*100%
A: III collagen type production quantity after addition test sample
B: it is not added with III collagen type production quantity of test sample
It the results are shown in Table 2.
Synthesis promotion rate of the different test samples of table 2 to III collagen type
| Group | Applying amount (mL) | Promotion rate (%) |
| Embodiment 9 | 1 | 162.1 |
| Reference examples 1 | 1 | 272.5 |
As seen from the above table, the anti-wrinkle essence that prepared by the embodiment of the present invention 9 and reference examples 1 can promote cell to III type glue
The secretion of former albumen, but the Essence promotion rate of preparation of the embodiment of the present invention is significantly larger than reference examples, can significantly improve III type
Collagen production quantity thickens extracellular matrix, and then realizes anti-wrinkle effect.
Human skin patch is carried out according to the above method using embodiment 7,8 obtained face mask for eliminating macula and whitening skin liquid and is dispelled
Spot, whitening effect test, obtain the test result similar with above-mentioned test result.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention that claims determine, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (10)
1. a kind of anti-wrinkle essence, which is characterized in that be prepared by weight by following raw material: jewfish Isin glue collagen peptide
50-70 parts, 35-45 parts of modified collagen albumen, 20-35 parts of tremella polysaccharides, 40-60 parts of aloe polysaccharide, 10-22 parts of honey, Chinese medicine
Crease-resistant liquid 5-15 parts, 1-5 parts of antioxidant, 10-25 parts of Chinese medicine ultraviolet absorber, 1-2 parts of butanediol, 1-5 parts of polyethylene glycol 400,
2-7 parts of glycerol, 5-10 parts of plants essential oil, 0.1-1 parts of EDTA2Na, 1-2 parts of Bis(hydroxymethyl)imidazolidinyl urea, emulsifier 2-
4 parts and deionized water 100-120 parts；
The modified collagen albumen is prepared by following methods: it weighs 2g collagen and is added in 100mL deionized water, 50 DEG C of water-baths
30min is dissolved, suction filtration obtains pure collagen solution, separately weighs 2g polyethylene glycol, and it is 2% that 100mL volume fraction, which is added,
Glacial acetic acid in, in 50 DEG C stirred in water bath dissolve 30min, by collagen and polyglycol solution according to l:2 mass ratio
Mixing, and the glycerol that mass fraction is 25% is added and makees plasticizer, stirring 10min is mixed under the conditions of 20 DEG C, in 65 DEG C of water-bath
Middle crosslinking 2h to obtain the final product.
2. a kind of anti-wrinkle essence according to claim 1, which is characterized in that be prepared by weight by following raw material:
60 parts of jewfish Isin glue collagen peptide, 40 parts of modified collagen albumen, 27 parts of tremella polysaccharides, 50 parts of aloe polysaccharide, 18 parts of honey, Chinese medicine
10 parts of crease-resistant liquid, 3 parts of antioxidant, 19 parts of Chinese medicine ultraviolet absorber, 1.5 parts of butanediol, 3 parts of polyethylene glycol 400,6 parts of glycerol,
7 parts of plants essential oil, 0.5 part of EDTA2Na, 1.5 parts of Bis(hydroxymethyl)imidazolidinyl urea, 3 parts of emulsifier and deionized water 110
Part.
3. a kind of anti-wrinkle essence according to claim 1, which is characterized in that the antioxidant is selected from 2,6- three-level butyl-
4- methylphenol, bis- (3,5- three-level butyl -4- hydroxy phenyl) thioethers, four (β-(3,5- three-level butyl -4- hydroxy phenyl) third
Acid) pentaerythritol ester, three monooctyl esters, three last of the ten Heavenly stems esters, three (Lauryl Alcohol) esters, three (16 carbon alcohol) esters, potassium sorbate, sorbic acid, cream
One or more of sour sodium, white reed alcohol, tea polyphenols and vitamin C.
4. a kind of anti-wrinkle essence according to claim 1, which is characterized in that the Chinese medicine ultraviolet absorber is by following raw material
It is prepared by weight: 27 parts of sophora flower, 20 parts of Radix Astragali, 15 parts of semen coicis, 15 parts of polygonum cuspidate, 13 parts of the coptis, 10 parts of bitter buckwheat, sweet basil
7 parts, 5 parts of tsaoko and 2 parts of the sophora bud.
5. a kind of anti-wrinkle essence according to claim 4, which is characterized in that the Chinese medicine ultraviolet absorber is by following methods
It is prepared: weighing sophora flower, Radix Astragali, semen coicis, polygonum cuspidate, the coptis, bitter buckwheat, sweet basil, tsaoko and the sophora bud in proportion, dry rear powder
It is broken, deionized water is added according to solid-to-liquid ratio 1:20, after impregnating for 24 hours, after 500W microwave heating to 100 DEG C of reflux 5h, filters, collects
Filtrate；Deionized water is added according to weight ratio 1:1 in filter residue, after the stagnant 100 DEG C of reflux 2h of 500W microwave heating, filtering, and collection filtrate,
Merge filtrate twice, being concentrated into density is 1.5-2g/cm3To get Chinese medicine ultraviolet absorber.
6. a kind of anti-wrinkle essence according to claim 1, which is characterized in that the crease-resistant liquid of Chinese medicine is by following raw material by weight
Amount part is prepared: 10 parts of crape myrtle, 10 parts of rhizoma polygonati, 10 parts of fructus lycii, 10 parts of Radix Salviae Miltiorrhizae and 10 parts of tripterygium wilfordii.
7. a kind of anti-wrinkle essence according to claim 6, which is characterized in that the crease-resistant liquid of Chinese medicine is prepared by following methods
It forms: weighing crape myrtle, rhizoma polygonati, fructus lycii, Radix Salviae Miltiorrhizae and tripterygium wilfordii in proportion, crushed after drying, ethyl alcohol-is added according to solid-to-liquid ratio 1:10
Butanone volume ratio is the mixed solvent of 1:1, is heated to 50 DEG C after impregnating 2h, 5-7h, filtering are extracted in 200r/min stirring, and revolving is removed
Solvent is removed, the crease-resistant liquid of Chinese medicine is obtained.
8. a kind of anti-wrinkle essence according to claim 1, which is characterized in that the plants essential oil is selected from lavender oil, lemon
One or more of lemon oil, bergamot oil, caryophyllus oil, peppermint oil, cinnamon oil, attar of rose.
9. a kind of anti-wrinkle essence according to claim 1, which is characterized in that the emulsifier is selected from odium stearate, tristearin
One of sour potassium, sodium palmitate, potassium palmitate, lauryl sodium sulfate, twain series emulsifier and Span series emulsifier
Or it is several, the twain series emulsifier includes but are not limited to Tween-20, Tween-40, Tween-60, Tween-80；The department
Disk series emulsifier includes but are not limited to Arlacel-20, Arlacel-40, Arlacel-60, Arlacel-80.
10. a kind of preparation method of anti-wrinkle essence described in -9 any claims according to claim 1, which is characterized in that press
It is prepared according to following steps:
(1) tremella polysaccharides, aloe polysaccharide, honey, polyethylene glycol 400, glycerol and EDTA2Na are added in reactor, are added
1/2 deionized water is heated to 70 DEG C, and stirring 30min dissolution completely, obtains A liquid；
(2) by jewfish Isin glue collagen peptide, modified collagen albumen, the crease-resistant liquid of Chinese medicine, antioxidant, Chinese medicine ultraviolet absorber and fourth two
Alcohol is added to the container, and 1/4 deionized water is added, heating stirring 20min is to being completely dissolved, and temperature control is at 75 DEG C hereinafter, obtaining
To B liquid；
(3) under constant stirring, slowly B liquid is added in A liquid, emulsifier is added, keep 70 DEG C of 2-3 points of fast homogeneous stirrings
Clock makes into lotion, continuously adds Bis(hydroxymethyl)imidazolidinyl urea, butanediol and plants essential oil, continues to stir evenly, be cooled to
Room temperature, bottling, obtains anti-wrinkle essence.
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Cited By (6)
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| CN110200841A (en) * | 2019-05-23 | 2019-09-06 | 江苏农林职业技术学院 | A kind of cicada fungus tremella face mask liquid and preparation method thereof |
| CN110507582A (en) * | 2019-09-23 | 2019-11-29 | 中国科学院烟台海岸带研究所 | A kind of anti-ageing remediation composition and its preparation method and application containing composite vegetables extractive |
| CN111481473A (en) * | 2020-04-13 | 2020-08-04 | 佛山秘码中医馆有限公司 | Conditioning essence for enhancing skin metabolism function |
| CN113304097A (en) * | 2021-05-27 | 2021-08-27 | 上海南滨江细胞生物科技有限公司 | Essence containing stem cell exosomes and preparation method thereof |
| CN114788860A (en) * | 2022-06-23 | 2022-07-26 | 深圳德荫堂生物科技有限公司 | Externally applied medicine for promoting skin metabolism and preparation method thereof |
| CN118453440A (en) * | 2024-05-08 | 2024-08-09 | 湖南省青耕生物产业创新研究院有限公司 | Modified collagen anti-wrinkle mask and preparation method thereof |
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2018
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200841A (en) * | 2019-05-23 | 2019-09-06 | 江苏农林职业技术学院 | A kind of cicada fungus tremella face mask liquid and preparation method thereof |
| CN110507582A (en) * | 2019-09-23 | 2019-11-29 | 中国科学院烟台海岸带研究所 | A kind of anti-ageing remediation composition and its preparation method and application containing composite vegetables extractive |
| CN111481473A (en) * | 2020-04-13 | 2020-08-04 | 佛山秘码中医馆有限公司 | Conditioning essence for enhancing skin metabolism function |
| CN113304097A (en) * | 2021-05-27 | 2021-08-27 | 上海南滨江细胞生物科技有限公司 | Essence containing stem cell exosomes and preparation method thereof |
| CN114788860A (en) * | 2022-06-23 | 2022-07-26 | 深圳德荫堂生物科技有限公司 | Externally applied medicine for promoting skin metabolism and preparation method thereof |
| CN118453440A (en) * | 2024-05-08 | 2024-08-09 | 湖南省青耕生物产业创新研究院有限公司 | Modified collagen anti-wrinkle mask and preparation method thereof |
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