CN107789253A - A kind of anti-acne moisturizing skin care item and preparation method thereof - Google Patents
A kind of anti-acne moisturizing skin care item and preparation method thereof Download PDFInfo
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- CN107789253A CN107789253A CN201711056217.4A CN201711056217A CN107789253A CN 107789253 A CN107789253 A CN 107789253A CN 201711056217 A CN201711056217 A CN 201711056217A CN 107789253 A CN107789253 A CN 107789253A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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Abstract
The invention discloses a kind of anti-acne moisturizing skin care item, and it contains the raw material of following weight/mass percentage composition：Mangosteen extract 3~10%, Honegsukle flower P.E 1~5% and needle juniper extract 1~6%.Meanwhile the invention also discloses the preparation method of the anti-acne moisturizing skin care item.Anti-acne moisturizing skin care item provided by the invention contain a variety of natural plant active extracts, safe and non-stimulating, can effectively improve scaly dry skin, fat secretion imbalance and the problems such as long acne, make skin water profit, salubrious, have good moisturizing, oil-control and acne-removing.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of anti-acne moisturizing skin care item and preparation method thereof.
Background technology
Whelk, acne, dark sore are medically referred to as acne, i.e., usually said " acne ", it is due to hair follicle and skin
A kind of skin disease caused by adipose gland obstruction, inflammation.Its Producing reason is mainly that smegma is vigorous, causes clogging of pores
The core of an acne is formed, with the focusing of the breeding of bacterium and dust in air and sebum, gradual enlargement, inflammation, so as to
Form acne.With the aggravation of environmental pollution, life stress increase and change of dietary structure etc., increasing people is by long acne
Puzzlement, it not only influences the appearance and confidence of people, people is produced passive mood to working and living, can also shape when serious
Into skin disease.Therefore anti-acne is also one of research focus of cosmetics.
At present, the limitation that commercially available anti-acne skin care item are formulated due to itself, it can only achieve mitigation disease to a certain extent
Shape, anti-acne effect is undesirable, and the cycle is longer, does not reach preferable oil control and acne removal effect at all to more serious acne.One
The good product for resolving poxes of money at least while possesses the effect of following several respects：The impaired skin of oil-control, moisturizing and reparation.It is but existing
Product for resolving poxes tends not to have above-mentioned effect simultaneously.
The content of the invention
Based on this, a kind of anti-acne moisturizing shield is provided it is an object of the invention to overcome above-mentioned the deficiencies in the prior art part
Skin product, it contains a variety of natural plant active extracts, safe and non-stimulating, can effectively improve scaly dry skin, fat secretion imbalance
The problems such as with long acne.
To achieve the above object, the technical scheme taken of the present invention is：A kind of anti-acne moisturizing skin care item, contain following quality
The raw material of percentage composition：Mangosteen extract 3~10%, Honegsukle flower P.E 1~5% and needle juniper extract 1~6%.
Preferably, the anti-acne moisturizing skin care item contain the raw material of following weight/mass percentage composition：Mangosteen extract 5~8%,
Honegsukle flower P.E 2~3.5% and needle juniper extract 2~4%.
Preferably, the anti-acne moisturizing skin care item contain the raw material of following weight/mass percentage composition：Mangosteen extract 6.5%,
Honegsukle flower P.E 3% and needle juniper extract 2.5%.
Preferably, the anti-acne moisturizing skin care item contain the raw material of following weight/mass percentage composition：Mangosteen extract 4%, gold
Honeysuckle flower extract 1.5% and needle juniper extract 5%.
Preferably, the anti-acne moisturizing skin care item contain the raw material of following weight/mass percentage composition：Mangosteen extract 5%, gold
Honeysuckle flower extract 2.5% and needle juniper extract 3%.
Present inventor has found by substantial amounts of research, by mangosteen extract, Honegsukle flower P.E and needle juniper extract
Skin care item are prepared as raw material compounding, synergy well is produced between each raw material, there is significant moisturizing, anti-acne and oil-control
Effect.The compatibility amount of raw material is that inventor gets by the analysis of substantial amounts of Research statistics, and each raw material can in the amount ranges
Synergy well is played, is not had any side-effects simultaneously.
It is another object of the present invention to provide the preparation method of the anti-acne moisturizing skin care item.
To achieve the above object, the technical scheme taken of the present invention is：A kind of preparation method of anti-acne moisturizing skin care item, its
It is characterised by, comprises the following steps：
(1) described mangosteen extract, Honegsukle flower P.E and needle juniper extract are weighed in proportion, are mixed；
(2) mixture in step (1) is slowly added to the skin care made of other acceptable auxiliary materials of skin care field
In product matrix, stir, be incubated 30min, produce the anti-acne moisturizing skin care item.
Preferably, in the step (2) under conditions of no more than 40 DEG C by the mixture in step (1) be slowly added to by
In skin care item matrix made of other acceptable auxiliary materials of skin care field.
Preferably, the mangosteen extract preparation method comprises the following steps：Mangosteen is weighed, is crushed, adds coarse powder weight
The mass fraction of 6 times of volumes is measured as 80% ethanol solution, refluxing extraction 2 times under the conditions of 80 DEG C, each 2h；Extract solution mistake
Filter, merging filtrate, is concentrated under reduced pressure, is drying to obtain.
Preferably, the skin care item include facial mask, face cream, eye cream, emulsion, toner or Essence.
Relative to prior art, beneficial effects of the present invention are：Anti-acne moisturizing skin care item provided by the invention contain a variety of
Natural plant active extract, it is safe and non-stimulating, it can effectively improve scaly dry skin, fat secretion imbalance and the problems such as long acne, repair
Skin is damaged again, moistens skin water, be salubrious, there is good moisturizing, oil-control and acne-removing.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.It should be noted that the percentage of raw material is all mass percent in the present invention.
Embodiment 1
A kind of embodiment of anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen extracts
Thing 3%, Honegsukle flower P.E 1% and needle juniper extract 1%, surplus are skin care item matrix.
The skin care item matrix formulations are：Glycerine 5%, propane diols 5%, butanediol 4%, hyaluronic acid 0.03%, essence
0.2% and preservative 0.5%, surplus be deionized water.
Embodiment 2
A kind of embodiment of anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen extracts
Thing 10%, Honegsukle flower P.E 5% and needle juniper extract 6%, surplus are skin care item matrix.
The skin care item matrix formulations are the same as embodiment 1.
Embodiment 3
A kind of embodiment of anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen extracts
Thing 4%, Honegsukle flower P.E 1.5% and needle juniper extract 5%, surplus are skin care item matrix.
The skin care item matrix formulations are the same as embodiment 1.
Embodiment 4
A kind of embodiment of this anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen carries
Thing 5%, Honegsukle flower P.E 2.5% and needle juniper extract 3% are taken, surplus is skin care item matrix.
The skin care item matrix formulations are the same as embodiment 1.
Embodiment 5
A kind of embodiment of anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen extracts
Thing 6.5%, Honegsukle flower P.E 3% and needle juniper extract 2.5%, surplus are skin care item matrix.
The skin care item matrix formulations are the same as embodiment 1.
Embodiment 6
A kind of embodiment of anti-acne moisturizing skin care item preparation method of the present invention, comprises the following steps：
(1) described mangosteen extract, Honegsukle flower P.E and needle juniper extract are weighed in proportion, are mixed；
(2) mixture in step (1) is slowly added to acceptable other are auxiliary by skin care field under the conditions of 40 DEG C
In skin care item matrix made of material, stir, be incubated 30min, produce the anti-acne moisturizing skin care item.
The skin care item matrix formulations are prepared with embodiment 1 according to the preparation method that skin care field is commonly used.
The mangosteen extract preparation method comprises the following steps：(1) mangosteen is weighed, is crushed, adds 6 times of coarse powder weight
The mass fraction of volume is 80% ethanol solution, refluxing extraction 2 times under the conditions of 80 DEG C, each 2h；Extract solution filters, and merges
Filtrate, it is concentrated under reduced pressure, is drying to obtain.
The Honegsukle flower P.E preparation method comprises the following steps：Honeysuckle is crushed, adds the matter of 8 times of coarse powder weight
The ethanol that fraction is 80% is measured, heating and refluxing extraction 2 times, each 1.5h merges extract solution, and concentration removes ethanol, produced.
The needle juniper method for preparing extractive comprises the following steps：Coarse powder is made in red bark of eucommia, adds 8 times of coarse powder weight
Mass fraction is 85% ethanol, heating and refluxing extraction 3 times, each 1h, extract solution filtering, merging filtrate, ethanol is recovered under reduced pressure,
It is drying to obtain.
Embodiment 7
The present embodiment is tested the effect of skin care item in embodiment 1~5.
(1) method of testing
1st, 200 health volunteers are chosen, the age is between 30~55 years old.All subjects are randomly divided into 5 surveys
Examination group, respectively using the skin care item in embodiment 1~5.Appropriate skin care item are taken to apply after subject's morning and evening face cleaning of all test groups
Smear in face, and softly massage 2~3min, promote to absorb.Trial employment period prevents solar exposure, and prohibits the use of other skin cares
Product.After continuous use one month, anti-acne, moisturizing and the detection of oil-control effect and record are carried out to all subjects.
2nd, reparation effect of skin care item is evaluated using moisture loss rate
A, cavy 48 is taken, female half and half, body weight is 350 ± 20g.The instep shaving behind 1 day right side before experiment, is randomly divided into
6 groups, the skin care item that experimental group is prepared using embodiment 1~5 respectively, control group uses distilled water.B, l days before experiment, by 6 groups
Cavy is anesthetized with ether, and cuts nape part hair, and area is 2 × 2cm2.C, acetone is taken：Ether=1:The μ L drops of 1 mixed liquor 150 are in going
At hair, then the skin care item of Example 1~5 and the μ L drops of distilled water 150 are at cropping respectively, 2 times/day.C, German CK is utilized
Transepidermal water loss rate at skin water loss tester (TM300-Tewamater) the measurement cavy depilation of company.At cavy depilation
Transepidermal water loss rate is lower, and it is better to show that skin care item repair effect.
(2) effect assessment standard
1st, skin care item anti-acne effect of the present invention is evaluated using standard described in table 1：
The skin care item anti-acne effect evaluation criterion of the present invention of table 1
| Gradation of effects | Effect standard |
| 8~10 points | Subject is very satisfied to anti-acne effect, facial small pox regression more than 90%. |
| 6~8 points | Subject is relatively satisfactory to anti-acne effect, facial small pox regression more than 60%. |
| 4~6 points | Subject is satisfied in the main to anti-acne effect, facial small pox regression more than 30%. |
| 0~4 point | Subject is unsatisfied with to anti-acne effect, and facial small pox does not obtain any improvement. |
2nd, the moisturizing effect of skin care item of the present invention is evaluated using the rate of change of skin moisture content, specific method is as follows：
Skin moisture content：Using German CK companies skin moisture tester (Corneometer CM825) measure by
The moisture of examination person's face skin.Before on-test, first the moisture of each subject's skin is detected, and
Record；After experiment one month, the moisture of each subject's skin is detected again, and records.Utilize following public affairs
Formula calculates the climbing of skin moisture：Numerical value before moisture climbing=(numerical value before numerical value-experiment after experiment)/experiment
× 100%.Moisture climbing is bigger, shows that moisturizing effect is better.
3rd, the oil-control effect of skin care item of the present invention is evaluated using the rate of change of skin oil and fat content, specific method is as follows：
Skin oil and fat content：The cortex number of subject's face skin is determined using the SM815 detection modes of German CK companies
Value.Before on-test, first the cortex numerical value of each subject's skin is detected, and records；After experiment one month, then
The secondary cortex numerical value to each subject's skin is detected, and recorded.The decline of fat content is calculated using below equation
Rate：Numerical value × 100% before fat content rate of descent=(numerical value after numerical value-experiment before experiment)/experiment.Fat content rate of descent is got over
Greatly, show that oil-control effect is better.
4th, reparation effect of skin care item is evaluated using moisture loss rate, transepidermal water loss rate is lower at cavy depilation, shows to protect
It is better that skin product repair effect.
5th, the evaluation criterion of security of the present invention is as shown in table 2：
The evaluation criterion of 2 security of the present invention of table
(3) test result
After one month, the using effect of all subjects is counted, while results of animal is analyzed.Knot
Fruit is as shown in table 3.
The skin care item measure of merit result of the present invention of table 3
As shown in Table 3, skin care item are respectively provided with extraordinary anti-acne, moisturizing, oil-control and reparation in the embodiment of the present invention 1~5
Effect, after subject uses one month, long acne problem is greatly improved, small pox disappearance more than 90%.Moisture of skin contains simultaneously
The obvious rising of amount, fat content are decreased obviously.And all subjects do not occur in use allergy, general red, itch or
It is phenomena such as long acne, safe and non-stimulating.Wherein, the skin care item using effect in embodiment 5 is best.
Embodiment 8
Skin care item of the present invention include mangosteen extract, Honegsukle flower P.E and needle juniper extract.To study raw material of skin care articles
Influence of the selection to anti-acne, moisturizing, oil-control and repairing effect, raw material selection of the present embodiment to skin care item tested.
(1) experimental design
To inquire into influence of the selection of raw material to skin care item effect of the present invention, contrived experiment group 1~4, specifically such as the institute of table 4
Show.The dosage of each raw material is the same as embodiment 5, the same implementation of preparation method of each raw material extracting method and skin care item in experimental group 1~4
Example 6.
The experimental group of table 4 designs
| Experimental group | Raw material of skin care articles forms |
| Experimental group 1 | Mangosteen extract, Honegsukle flower P.E and needle juniper extract |
| Experimental group 2 | Honegsukle flower P.E and needle juniper extract |
| Experimental group 3 | Mangosteen extract and needle juniper extract |
| Experimental group 4 | Mangosteen extract and Honegsukle flower P.E |
(2) experimental method
1st, 200 health volunteers are chosen, the age is between 30~55 years old.All subjects are randomly divided into 4 surveys
Examination group, respectively using the skin care item in experimental group 1~4.Appropriate skin care item are taken to apply after subject's morning and evening face cleaning of all test groups
Smear in face, and softly massage 2~3min, promote to absorb.Trial employment period prevents solar exposure, and prohibits the use of other skin cares
Product.After continuous use one month, anti-acne, moisturizing and the detection of oil-control effect and record are carried out to all subjects.
2nd, reparation effect of skin care item is evaluated using moisture loss rate
A, cavy 40 is taken, female half and half, body weight is 350 ± 20g.The instep shaving behind 1 day right side before experiment, is randomly divided into
5 groups, the skin care item that experimental group is prepared using experimental group 1~4 respectively, control group uses distilled water.B, l days before experiment, by 5 groups
Cavy is anesthetized with ether, and cuts nape part hair, and area is 2 × 2cm2.C, acetone is taken：Ether=1:The μ L drops of 1 mixed liquor 150 are in going
At hair, then the skin care item of Example 1~5 and the μ L drops of distilled water 150 are at cropping respectively, 2 times/day.C, German CK is utilized
Transepidermal water loss rate at skin water loss tester (TM300-Tewamater) the measurement cavy depilation of company.At cavy depilation
Transepidermal water loss rate is lower, and it is better to show that skin care item repair effect.
(3) effect assessment standard
With embodiment 7.
(4) experimental result
Experimental result is as shown in table 5：
The experimental result of table 5
From the above results, best anti-acne, moisturizing, control can be obtained 3 kinds of raw materials of skin care item of the present invention use simultaneously when
Oil and the effect (experimental group 1) repaired.The composition of skin care item of the present invention is that inventor obtains by numerous studies, between each component
Good synergy can be produced.Lack any raw material, its effect can all be remarkably decreased (experimental group 2~4), especially lack
During few mangosteen extract, effect declines most obvious (experimental group 2).Other lack the experimental result and the present embodiment class of two kinds of raw materials
Seemingly, specific data are omitted.
Embodiment 9
Anti-acne moisturizing skin care item of the present invention, the raw material containing following weight/mass percentage composition：Mangosteen extract 3~10%, gold
Honeysuckle flower extract 1~5%, needle juniper extract 1~6%.To study influence of the raw material of skin care articles compatibility amount of the present invention to effect, this
Embodiment is studied the usage amount of each raw material of skin care item.
(1) experimental design
The present embodiment inquires into the usage amount of mangosteen extract to skin care item of the present invention by taking the usage amount of mangosteen extract as an example
The influence of using effect.Contrived experiment group 5~7 and control group 1~2, it is specific as shown in table 6.The use of other raw materials of each group
Amount is with embodiment 5, and the preparation method of each raw material extracting method and skin care item is the same as embodiment 6.
The experimental group of table 6 designs
| Experimental group | Usage amount/weight/mass percentage composition of mangosteen extract |
| Experimental group 5 | 3% |
| Experimental group 6 | 10% |
| Experimental group 7 | 6.5% |
| Control group 1 | 2.9% |
| Control group 2 | 10.1% |
(2) experimental method
1st, 300 health volunteers are chosen, the age is between 30~55 years old.All subjects are randomly divided into 5 surveys
Examination group, respectively using the skin care item in each group of table 6.Appropriate skin care item are taken to be applied to after subject's morning and evening face cleaning of all test groups
Face, and 2~3min is softly massaged, promote to absorb.Trial employment period prevents solar exposure, and prohibits the use of other skin care item.Even
Continue after using one month, anti-acne, moisturizing and the detection of oil-control effect and record are carried out to all subjects.
2nd, reparation effect of skin care item is evaluated using moisture loss rate
A, cavy 48 is taken, female half and half, body weight is 350 ± 20g.The instep shaving behind 1 day right side before experiment, is randomly divided into
6 groups, experimental group uses the skin care item prepared in each group of table 6 respectively, and control group uses distilled water.B, l days before experiment, by 5 groups
Cavy is anesthetized with ether, and cuts nape part hair, and area is 2 × 2cm2.C, acetone is taken：Ether=1:The μ L drops of 1 mixed liquor 150 are in going
At hair, then take in table 6 that each group skin care item and the μ L drops of distilled water 150 are at cropping respectively, 2 times/day.C, German CK companies are utilized
Skin water loss tester (TM300-Tewamater) measurement cavy depilation at transepidermal water loss rate.It is percutaneous at cavy depilation
Percentage of water loss is lower, and it is better to show that skin care item repair effect.
(3) effect assessment standard
With embodiment 7.
(4) experimental result
The effect for the skin care item that each group is prepared is evaluated, as a result as shown in table 7：
The experimental result of table 7
From above-mentioned experimental result, the usage amount of skin care item mangosteen extract of the present invention contains in 3~10% mass percentages
Good anti-acne, moisturizing, oil-control and repairing effect can be obtained when (experimental group 5~7) between amount, use not in this range
Amount (control group 1~2) can influence the using effect of skin care item.The usage amount of each raw material of skin care item of the present invention is that inventor passes through
The best proportion that many experiments count, the usage amount of each raw material can ensure skin care in the range of weight/mass percentage composition of the present invention
Product obtain good using effect, and any one raw material usage amount increases or decreases the cooperative effect that can all influence between raw material,
The effect of so as to influence skin care item.As control group 2 adds the usage amount of mangosteen extract, but its using effect does not have phase
It should improve, decline on the contrary.The experimental result of Honegsukle flower P.E and needle juniper extract usage amount is similar with the present embodiment, tool
Volume data is omitted.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (9)
- A kind of 1. anti-acne moisturizing skin care item, it is characterised in that the raw material containing following weight/mass percentage composition：Mangosteen extract 3~ 10%th, Honegsukle flower P.E 1~5% and needle juniper extract 1~6%.
- 2. anti-acne moisturizing skin care item according to claim 1, it is characterised in that the original containing following weight/mass percentage composition Material：Mangosteen extract 5~8%, Honegsukle flower P.E 2~3.5% and needle juniper extract 2~4%.
- 3. anti-acne moisturizing skin care item according to claim 1, it is characterised in that the original containing following weight/mass percentage composition Material：Mangosteen extract 6.5%, Honegsukle flower P.E 3% and needle juniper extract 2.5%.
- 4. anti-acne moisturizing skin care item according to claim 1, it is characterised in that the original containing following weight/mass percentage composition Material：Mangosteen extract 4%, Honegsukle flower P.E 1.5% and needle juniper extract 5%.
- 5. anti-acne moisturizing skin care item according to claim 1, it is characterised in that the original containing following weight/mass percentage composition Material：Mangosteen extract 5%, Honegsukle flower P.E 2.5% and needle juniper extract 3%.
- 6. the preparation method of the anti-acne moisturizing skin care item according to any one of Claims 1 to 5, it is characterised in that including with Lower step：(1) described mangosteen extract, Honegsukle flower P.E and needle juniper extract are weighed in proportion, are mixed；(2) mixture in step (1) is slowly added to the skin care item base made of other acceptable auxiliary materials of skin care field In matter, stir, be incubated 30min, produce the anti-acne moisturizing skin care item.
- 7. preparation method according to claim 6, it is characterised in that in the condition no more than 40 DEG C in the step (2) Mixture in lower (1) by step is slowly added to by skin care item matrix made of other acceptable auxiliary materials of skin care field.
- 8. preparation method according to claim 7, it is characterised in that the mangosteen extract preparation method includes following step Suddenly：Mangosteen is weighed, is crushed, the mass fraction for adding coarse powder 6 times of volumes of weight is 80% ethanol solution, under the conditions of 80 DEG C Refluxing extraction 2 times, each 2h；Extract solution filters, and merging filtrate, is concentrated under reduced pressure, is drying to obtain.
- 9. preparation method according to claim 6, it is characterised in that the skin care item include facial mask, face cream, eye cream, breast Liquid, toner or Essence.
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| WO2020263190A1 (en) * | 2019-06-25 | 2020-12-30 | Agency For Science, Technology And Research | Xanthones that decrease lipid production in sebocytes |
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