CN107456429A - A kind of oat rudiment extract and its application in cosmetics - Google Patents
A kind of oat rudiment extract and its application in cosmetics Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of preparation method of oat rudiment extract, the described method comprises the following steps：A) oat seed is provided；B) sprout, rudiment 17 days, obtains oat rudiment respectively；C) heated-air drying, normal temperature ultrasonic extraction；D) extract solution obtained in step c) is filtered；E) filtrate decompression obtained in step d) is concentrated, volatilizes solvent, obtain oat rudiment extract.Invention additionally discloses application of the oat rudiment extract in terms of skin irritatin and pruitus is alleviated.
Description
Technical field
The invention belongs to cosmetics preparation field, more particularly to a kind of preparation method of oat rudiment extract and the extraction
The purposes of thing, for skin nursing.Present invention relates particularly to the oat germ extract in stimulation and antipruritic cosmetics are alleviated
Application.
Background technology
In recent years, because reason, the allergic human populations such as the deterioration of the ecological environment, all types of industries additive abuse increase year by year, skin
Skin allergy turns into the big factor for influenceing human health.Sensitive is a kind of special skin type, refer to skin by
During environmental stimuli, easily there are the nbjective symptoms such as erythema, papule, telangiectasis, with itch, shouting pain, calcination, tight feeling etc.
Subjective symptom.Sensitive skin is mainly characterized by more drying, is easily tight and rubescent, by minimal irritation, you can produce scabies
Itch, furfur or even burn is felt with shouting pain etc., severe patient can produce unhealthy emotion or mental symptom.Therefore, for sensitive skin
The maintenance effect of skin, including the daily nursing carried out to sensitive skin and improvement, suppress skin wound repair, inflammation of releiving and mistake
It is quick, to self barrier function of raising skin, the stimulation of outer bound pair skin is resisted, improves skin state and has great importance.
The origin cause of formation of sensitive skin have it is a variety of, it is main including barrier function defect, nerves reaction is too strong or inflammatory reaction
Vicious circle, antiallergic activity is divided into barrier function maintenance, neuroleptic on this basis and suppresses the type of inflammation 3.Wherein,
It is to induce various inflammation due to extraneous adverse factor invasion and the loss of endotrophic material caused by skin barrier function defect
With the major reason of skin sensitivity.Compared with normal skin, there is barrier function damage or abnormality of nerve function in sensitive skin
Feature, it more difficult in the invasion and attack for resisting environmental stimuli thing and anaphylactogen, a series of dermatitis caused by stimulations or allergy easily occurs
Disease is reacted, and then further damages skin barrier structure and nerve endings, causes vicious circle.Therefore, inflammatory reaction is sensitive
Another key factor of skin, by suppressing the evaluation of inflammation effect to tested substance, it can reflect that it is contacted to sensitive skin
The inhibitory action of caused adverse reaction during external substance (stimulant or anaphylactogen) is strong and weak.
Interleukin-6 (Interleukin-6, IL-6), also referred to as Pro-inflammatory mediator, it is a kind of huge by monokaryon
The cell factor with multiple functions of phagocyte secretion, can pass through humoral and cellular immune response function effect inflammation, host defense
And tissue damage, it is one of medium of acute reaction, and one of important proinflammatory factor.Chemotactic factor (CF) is mainly by white
It is that one kind has chemotactic and activation to inflammatory cell secreted by the histocytes such as cell, epidermal cell and fibroblast
Cell factor, and interleukin 8 (Interleukin-8, IL-8) be then most important neutrophil chemotactic because
Son, mainly attract neutrophil leucocyte, eosinophil, basophilic granulocyte and T cell etc., be that neutrophil cell passes through blood
Endothelial tube reaches an important factor for inflammation part.IL-6 and IL-8 is immune and inflammatory reaction important regulatory factor, in skin
In skin inflammatory reaction, IL-6 is one of cell factor caused by keratinocyte (Keratinocyte, KC), is had to KC propagation
Facilitation；And IL-8 is then inflammatory chemokine important in scytitis reaction.Excessive IL-6 and IL- in cell tissue
8 can cause the inflammation damnification of skin, therefore, suppress the secretion of the inflammatory factors such as IL-6 and IL-8 to a certain extent, can be effective
Suppress the generation of inflammatory reaction, improve inflammation and the allergic reaction of skin.Research is it has also been found that the cell factor such as IL-6 and IL-8 exists
Played an important role in the pathophysiological process of inflammatory cutaneous itch, be usually used in the factor of pruritis analysis detection.
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (substance P, SP) is to find earliest neuropeptide in the world, is a kind of neuropeptide of high activity
Material, it is widely distributed in nervous system and other peripheral tissues' organs, there are different physiological roles.SP in skin is main
From Sensory nerve fibre tip, minority is by histocyte such as keratinocyte (KC), mast cell, mononuclear macrophage
Synthesized Deng cell.SP can promote epithelial cells release IL-1, IL-8, TNF-α, promote mononuclear macrophage to produce and discharge
IL-1, IL-6, TNF-α and IFN-γ, increase highly active T cell and produce IL-2 and expression IL-2 acceptors, stimulate mast cell
TNF-α is produced, neutrophil leucocyte and vascular endothelial cell produce II-8, and borrow the effect of these cell factors, influence and adjust
Control cutaneous immunisation and inflammatory reaction.Research shows that SP is a kind of important itch medium, can be by activating the direct of NK1 acceptors
Mode, or the indirect mode by promoting other itch media to discharge, participate in itch mechanism, so as to cause the redness of skin and scabies
Itch.
Bradykinin (bradykinin, BK) is a kind of kassinin kinin that it can be combined with bradykinin receptor B1 and B2, injection of skin
Being combined after bradykinin by the bradykinin receptor B2 with nerve fibre, make periphery thin vessels expansion, capillary permeability strengthens,
There is strong impulse effect to pain nerve tip simultaneously, so as to cause the inflammatory reactions such as the redness of skin, scabies itching and pain,
Therefore it is usually used in causing itch model as material incentive.
Oat (Classification system：Avena sativa L.) it is grass family Avena annual herb crop oat (Avena
Sativa L.) seed, it is the same with barley, high-energy and high nutritive value cereal are belonged to together, in recent years because it contains abundant egg
White matter, dietary fiber, vitamin and high-quality aliphatic acid, and as a kind of deep healthy food paid close attention to and liked by people.Oat
It is main to include mainly having dietary fiber, beta glucan, protein, polyphenoils, fat rich in abundant active nutrient component
Fat, vitamin, cellulose, mineral matter etc..Beta glucan is the main component for forming cereal cell membrane, cereal especially with barley and
Content is higher in oat；Beta glucan has efficient performance of keeping humidity, and can strengthen the protection to skin, resistance skin senescence and
The effect such as damage, is widely used in cosmetics.There are some researches show, the polyphenoils in oat be mainly oat fear acid amides,
Polyphenols, flavonoids, vitamin E, plant acid compounds, sterol, ω-hydroxy fatty acid, phosphatidyl choline and one
A little active peptides etc., they have preferable free-radical scavenging activity and reduction, so as to for resist skin injury or
Skin senescence.Active material in oat has significant nutritive effect, has very big exploitation in food and cosmetic field
Value.
Oat rudiment refers to the oat grain after germination and sprout, under appropriate conditions, oat water suction swelling, embryo
Bud is sprouted, and inside undergoes a series of physiological acoustic signals and material transformations, grows up to new individual, its nutritional ingredient has also changed
Become.Research finds that the crude protein of oat, crude fat, reduced sugar, starch, B- glucans, magnesium elements and VE contents have after rudiment
Reduced, but its total dietary fiber, calcium constituent and iron content add 63.19%, 13.33% and 33.45% (ginseng respectively
Examine document《Oat rudiment technical study and its Analysis of Nutritive Composition》), illustrate oat rudiment on nutrient composition content with oat
Itself is there is significant difference, but there has been no oat rudiment and oat, the comparative study in terms of effect is reported in itself at present.
In recent years, had been reported that the application study of oat and its auxiliary product in terms of the cosmetics, multinomial research report shows, oat tool more
There are antiallergy, anti-inflammatory, antipruritic etc. to act on (bibliography《Oat alkaloid and its potential health-care effect》、《The fragrant company of moral pushes away
Go out new antiallergic active component SymCalmin》、《Oat is had a bath and controls pruitus》、《Colloid oat (Avena sativa) anti-inflammatory is lived
Property contribute to drying, stimulate skin itch processing in oat validity》(Anti-Inflammatory
Activities of Colloidal Oatmeal(Avena sativa)Contribute to the Effectiveness
of Oats in Treatment of Itch Associated With Dry,Irritated Skin)、《The oat of oat
Anthracene acid amides and polyphenol show anti-inflammatory and antipruritic activity》(polyphenols from oats,exhibit anti-
inflammatory and anti-itch activity)、《Colloidal oatmeal powder protects damaged skin》(Colloidal oat
Flour protects damaged skin) etc.), its research contents focuses primarily upon certain or in oat of oat in itself
The effect of active material such as alkaloid, polyphenol etc., is studied.At present, application study of the oat rudiment in cosmetics is less, patent
A kind of oat extract is relate in CN201010130697.6, the extract is obtained by water extraction amylase enzymolysis, and
With long-acting performance of keeping humidity；A kind of swallow rudiment extract and its application are relate in patent CN201510291087.7, this is carried
Take thing be the oat rudiment with germination 4 days by the compound collecting of water and polyalcohol and being obtained by extraction, and the extract has U.S.
In vain, the effect of moisturizing, firm skin；There has been no the antiallergy on oat rudiment, alleviate and stimulate and the dependent interaction such as antipruritic
Document or patent report.
In recent years, due to its abundant active component and its effect, the cosmetic applications of raw material are used as using oat extract
Gradually increase, but it is seldom to the utilization of oat rudiment.Based on oat rudiment and difference of the oat seed on composition and its content
The opposite sex, if being developed and utilized to oat rudiment, it will obtain the cosmetic result different from oat extract.
The application investigates it to the application in terms of stimulation and itch is alleviated first using oat germ as research object.
The content of the invention
The present inventor have passed through extensively and found after in-depth study：Oat rudiment extract has anti-mistake
It is quick, alleviate and stimulate and the dependent interaction such as antipruritic.Therefore, oat rudiment extract can be added to outside skin as functional additive
With agent, especially in cosmetics, for alleviating skin irritatin and pruitus.
On the one hand, the invention provides a kind of preparation method of oat rudiment extract, the described method comprises the following steps：
A) oat seed is provided；
B) sprout, rudiment 1-7 days, obtains oat rudiment respectively；
C) heated-air drying, normal temperature ultrasonic extraction；
D) extract solution obtained in step c) is filtered；
E) filtrate decompression obtained in step d) is concentrated, volatilizes solvent, obtain oat rudiment extract.
In some specific embodiments, above-mentioned steps a) includes washing oat seed, removes the seed of floating.
In some specific embodiments, at a temperature of above-mentioned steps b) is included in 15-25 DEG C, 70-90%'s is relative
Under humidity, carried out under dark conditions.
In some specific embodiments, above-mentioned steps b) sprouting continues 2-3 days.
In some specific embodiments, above-mentioned steps c) uses volumetric concentration 60-80% ethanol, preferably 70% ethanol
Extracted.
On the other hand, the invention provides a kind of oat rudiment extract being prepared through the method for the invention.
On the other hand, the invention further relates to the oat rudiment extract that the inventive method is prepared to alleviate skin irritatin
In application.
On the other hand, the invention further relates to the oat rudiment extract that the inventive method is prepared to alleviate pruitus
In application.
On the other hand, the oat rudiment extract being prepared through the method for the invention is included the invention further relates to a kind of
Skin preparations for extenal use.
In some specific embodiments, percentage by weight of the oat rudiment extract in skin preparations for extenal use is
0.0001%-20% (w/w), preferable percentage by weight are 0.001%-10% (w/w), and preferred percentage by weight is
0.001%-5% (w/w), most preferred percentage by weight are 0.01%-5% (w/w).
Detailed description of the invention
More significantly alleviate stimulation than oat extract present invention firstly discovers that oat rudiment extract has, suppress scabies
The effect itched, it is preferable to sprouting the oat rudiment extract of 1~7 day, it is more preferred to sprout the oat of 1~3 day
Rudiment extract, optimal is the oat rudiment extract of sprouting 2~3 days.
The invention provides a kind of oat rudiment extract with alleviation stimulation, relieving itching effect.The present invention is sent out first
Existing oat rudiment extract has the effect of alleviating skin irritatin and pruitus, is suitable as functional additive and is used for outside skin
With in agent.
The invention provides a kind of preparation method of oat rudiment extract, its preparation comprises the following steps：
A) oat seed is provided；
B) sprout, rudiment 1-7 days, obtains oat rudiment respectively；
C) heated-air drying, normal temperature ultrasonic extraction；
D) extract solution obtained in step c) is filtered；
E) filtrate obtained in step d) is concentrated, volatilizes solvent, obtain oat rudiment extract.
In some specific embodiments, step a) includes washing oat seed.For example, (such as it can be purified with water
Water, deionized water etc.) washing oat seed.By washing, the superincumbent seed of floating can be removed, leave and be deposited in bottom
Seed.Follow-up sprouting step is then deposited in the seed of bottom using these.
Heretofore described oat seed is Avena stivai, and original producton location is Jeollabuk-do, Korea, is passed through
" SanDleYeongNong " supplier purchases seed.
In some specific embodiments, step b) is carried out at a temperature of 15-25 DEG C.In some specific embodiment party
In formula, step b) is carried out under 70-90% relative humidity.In some specific embodiments, step b) is in dark conditions
Lower progress.In some preferred embodiments, the Germination Temperature of the oat malt can be 15-20 DEG C, and more preferably temperature is
20℃.In some preferred embodiments, the sprouting relative humidity of the oat malt is 80%.In addition, in order to avoid seed
It is dried-up, it can continue to provide water (such as purified water, deionized water etc.), the moisture enough to seed and battalion during germination process
Support.
In some specific embodiments, sprout time can be any of 1,2,3,4,5,6,7 day.Another
In a little specific embodiments, sprout time can be 1-7 days, preferably 1-4 days.In other specific embodiments, sprout
It can be 2-6 days, more preferably 2-4 days, most preferably 2-3 days to send out the time.
In some specific embodiments, step c) drying is carried out using air drier.For example, the hot air drying
Dry temperature is 40-60 DEG C, and preferable temperature is 50 DEG C.In addition, normal temperature condition includes 25 ± 5 DEG C of temperature range.
In some specific embodiments, the material ratio of step c) extract is 1:5 to 1:15, preferred feed ratio is
1:10.In some specific embodiments, Extraction solvent is 60-80% ethanol (volumetric concentration), and preferred solvent is 70% second
Alcohol (volumetric concentration).In some specific embodiments, ultrasonic extraction temperature is 20-30 DEG C, and preferably ultrasonic extraction temperature is
25℃.In some specific embodiments, the ultrasonic extraction time is 2-4 hours, and the preferably ultrasonic extraction time is 3 hours.
In some specific embodiments, step d) filtering can be sieving, suction filtration, filter paper filtering.It is specific at some
Embodiment in, step d) filtering is filtered using filter paper, it is for instance possible to use HYUNDAI No.53 filter paper is filtered.
In some specific embodiments, step e) condensing modes are to be concentrated under reduced pressure, and preferably thickening temperature is 45 DEG C.
The present invention is alleviating stimulation, mitigation/suppression itch effect by comparing oat extract and oat rudiment extract
On otherness, show oat rudiment extract provided by the present invention can be applied to prepare cosmetics, be particularly suitable for use in slow
Solution stimulates, suppresses the skin preparations for extenal use such as itch.
The invention further relates to application of the oat rudiment extract in skin irritatin is alleviated.In some specific embodiments
In, the effect for alleviating skin irritatin is realized by suppressing the epidermal cell death efficiency of SLS inductions.
The invention further relates to application of the oat rudiment extract in pruitus is alleviated.In some specific embodiments
In, the effect for suppressing pruitus is that IL-6, IL-8 nucleus formation induced by suppressing Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (or bradykinin) is realized
's.
In another aspect of this invention, there is provided a kind of that there is the skin preparations for extenal use for alleviating skin irritatin effect, the skin
Skin external preparation includes includes oat rudiment extract and the acceptable tax of cosmetic field according to what the inventive method was prepared
Shape agent.
In another aspect of this invention, there is provided a kind of that there is the skin preparations for extenal use for alleviating pruitus effect, the skin
Skin external preparation includes includes oat rudiment extract and the acceptable tax of cosmetic field according to what the inventive method was prepared
Shape agent.
Oat rudiment extract can be applied to skin preparations for extenal use, especially can be applied in cosmetics, according to preparation not
Same type adds different dosages.
Oat rudiment extract of the present invention can as with alleviate skin irritatin effect additive application in
Skin preparations for extenal use.In a specific embodiment, oat rudiment extract, which can be used as to have, alleviates skin irritatin effect
Additive application in cosmetics.In a specific embodiment, the cosmetics are selected from：Mildy wash, toner, breast
Liquid, cream, gel, facial mask.Different dosages is added according to the different type of preparation.
Oat rudiment extract of the present invention can as with alleviate pruitus effect additive application in
Skin preparations for extenal use.In a specific embodiment, oat rudiment extract, which can be used as to have, alleviates pruitus effect
Additive application in cosmetics.In a specific embodiment, the cosmetics are selected from：Mildy wash, toner, breast
Liquid, cream, gel, facial mask.Different dosages is added according to the different type of preparation.
The skin preparations for extenal use of oat rudiment extract containing the present invention falls within protection scope of the present invention.
The skin preparations for extenal use is typically used for the general designation concept of all the components outside skin, such as can be cosmetic preparation
Composition or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, body in the cosmetic combination
Makeup material, hair nursing cosmetic preparation etc., can reasonable selection according to different purposes to its formulation without specifically limited.
Bu Tong also allowed in the cosmetic combination according to formulation and purpose containing different cosmeceutical aspects
Medium or matrix excipients.
It can be used for cosmetics, dermatology or the pharmaceutically acceptable excipient of Dermatologic preparation composition of the present invention
For the form of aqueous phase, oil phase, gel, water bag wax pattern emulsion, emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is a kind of or more
The mixture of water-soluble or dispersed component is planted, it can be liquid, semisolid or solid under room temperature (25 DEG C).Excipient bag
The form of suspension in water or water-alcohol excipient, dispersion liquid or solution is included or can be, it can contain thickener or solidifying
Jelly.The suitable product form of knowledge-chosen that those skilled in the art can be grasped based on those skilled in the art, wherein wrapping
The component contained.
Described composition can include aqueous phase, and the aqueous phase can contain water or water and at least one hydrophilic organic solvent
Mixture, described hydrophilic organic solvent such as alcohol, the rudimentary unitary of straight or branched especially containing 2-5 carbon atom
Alcohol, such as ethanol or propyl alcohol；Polyalcohol, such as propane diols, sorbierite, glycerine, panthenol or polyethylene glycol and its mixture.
When the composition of invention is emulsion form, said composition can also optionally include surfactant.
Described composition can also include film forming polymer, such as polyurethanes, polyacrylic acid homopolymer or copolymerization
Thing, polyester, resin and/or silicone resin based on hydrocarbon.It can dissolve a polymer in or be scattered in the acceptable tax of cosmetics
Optionally merge in shape agent and with plasticizer.
The composition of the present invention can also include oil phase, and described oil phase contains under room temperature (25 DEG C) for the oily molten of liquid
Property or oil-dispersing property component and/or be oily or wax-like material at room temperature, such as wax, semisolid, natural gum and its mixture.Should
Oil phase can also contain organic solvent.
It is generally liquid at room temperature, suitable oily matter includes：From the oil based on hydrocarbon of animal, such as perhydrogenating
Squalene；Vegetable oil based on hydrocarbon, such as the triglyceride of the C4-10 aliphatic acid of liquid, such as enanthic acid or Trivent OCG
Class, or oil, such as sunflower oil, corn oil, soybean oil, grape-kernel oil, castor oil, avocado oil, caprylic/capric triglyceride
Class, jojoba oil；The straight or branched hydro carbons of mineral or synthesis source, such as liquid paraffin and its derivant, vaseline；Synthesis
The esters of esters and ethers, particularly fatty alcohol, such as isopropyl myristate, palmitic acid 2- ethylhexyls, stearic acid 2- are pungent
Base dodecyl ester, isostearyl isostearate ester；Hydroxylating esters, for example, lactic acid isooctadecanol ester, octyl hydroxystearate,
Octyl hydroxystearate, hydroxy stearic acid octyldodecyl, the enanthic acid esters of fatty alcohol, sad esters and capric acid lipid；
Polyalcohol esters, such as propylene, the heptanoate of neopentyl glycol two, the isononoate of diethylene glycol (DEG) two and pentaerythritol ester
Class；Aliphatic alcohols containing C12-26, such as octyldodecanol, 2- butyl octanol, 2- hexyl decyl alcohols, 2- undecyls 15
Alkanol, oleyl alcohol；Fluorocarbon oil and/or fluorosilicon oil based on part hydrocarbon, silicone oil, it is at room temperature liquid or semisolid volatility or non-
Volatile straight chain or cyclo-methicone, such as X 2-1401 and dimethyl silicone polymer, its is optional
Include phenyl, such as Silicone DC 556, siloxanes and its mixture.
The composition of the present invention can be further comprising any component being usually used in cosmetic field.These components include
Preservative, water phase thickener (extract biopolymer, synthetic polymer) and fatty phase thickener, aromatic, hydrophily and
Lipophilic active agent and its mixture.
The composition of the present invention can also include other particle phase, and described particle can be mutually in cosmetic composition
The pigment and/or pearling agent and/or filler used.
Pigment may reside in composition, and suitable inorganic pigment includes titanium oxide, zirconium oxide and cerium oxide and oxygen
Change zinc, iron oxide and barba hispanica；Suitable organic pigment includes barium, strontium, calcium and aluminum lake and carbon black.
Pearling agent may reside in composition, and suitable pearling agent includes being coated with titanium oxide, iron oxide or natural face
The mica of material.
Filler may reside in composition, and suitable filler includes talcum powder, silica, zinc stearate, cloud
Mother, kaolin, nylon powder, polyethylene powders, Teflon, starch, borazon, copolymer microsphere, such as silicone resin
Microballon.
The oil phase of the present composition can include one or more waxes, natural gum or its mixture.Wax is included based on hydrocarbon
Wax, fluorine wax and/or siloxane wax, and plant, mineral, animal and/or synthesis source can be derived from.Suitable wax includes honeybee
Wax, Brazil wax, candelila wax, paraffin, microwax, ceresine；Synthetic wax includes Tissuemat E, the siloxanes containing C16-45
Wax.Natural gum is generally dimethyl silicone polymer or sodium carboxymethylcellulose or extraction species, and semi-solid material is generally base
In the compound of hydrocarbon, such as lanolin and its derivative.
The composition of the present invention can be configured to any suitable product form.This kind of product form includes, but unlimited
In aerosol spray, creme, emulsion, solid, liquid, dispersion, foam, gel, toner, mousse, ointment, pulvis,
Patch, brilliantine, solution, hand press pump-type spray, club, facial mask and hygenic towelette.The composition of the present invention can be passed through
Various methods well-known in the art are advantageously available for preparing or produced as cosmetics, dermatology or medicine local application
Product.
The Dermatologic preparation composition of the present invention can include one or more following ingredients：It is anti-allergic agent, antimicrobial
Agent, antioxidant, chelating agent, colouring agent depigmentation, emollient, emulsifying agent, excoriation agent, film forming agent, spices, moisturizing
It is agent, insect repellent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, preservative, skin conditioner, skin penetration enhancer, anti-
Shine agent, stabilizer, surfactant, thickener, viscosity modifier, vitamin or its any combination.
Brief Description Of Drawings
Fig. 1 shows the sprouting situation figure of embodiment 1-7 oat rudiment extract.
After Fig. 2 shows SLS processing, measurement result of the rudiment oat extract to cells survival degree.
Fig. 3 shows the influence for the IL-6/IL-8 generation efficiency that oat and oat rudiment extract are induced bradykinin.
Fig. 4 shows the influence for the IL-6/IL-8 generation efficiency that oat and oat rudiment extract are induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.
Embodiment
Oat rudiment extract is not directed in document has the effect of alleviating skin irritatin and/or pruitus, also not
Refer to and being added as with the additive for alleviating skin irritatin and/or alleviation pruitus in cosmetics.Therefore, it is of the invention
It is proposed that oat rudiment extract has the effect of alleviating skin irritatin and/or pruitus first, while the extract can also
Skin preparations for extenal use is added as functional additive, especially in cosmetics.
The present invention is expanded on further with reference to specific embodiment.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of unreceipted actual conditions in the following example, generally
According to normal condition, or according to the condition proposed by manufacturer.Unless otherwise indicated, all percentage and number be by weight
Meter.
Used oat kind is Avena stivai in embodiment, and original producton location is Jeollabuk-do, Korea, is passed through
" SanDleYeongNong " supplier purchases seed.
The experimental method, it is conventional method unless otherwise specified；The reagent and material, unless otherwise specified,
Commercially obtain.
Comparative example：The preparation of oat extract
The appropriate oat seed do not sprouted is taken, after being dried with air drier (temperature is adjusted to 50 DEG C), with 10 times of amounts 70%
Ethanol (volumetric concentration), normal temperature (25 ± 5 DEG C) ultrasonic extraction 3h, after being filtered with filter paper (HYUNDAI No.53), 45 DEG C of decompressions
Solvent is volatilized, obtains oat extract (powdered).
Embodiment 1：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 24h, arbitrarily select 5 seeds and measure rudiment length with ruler.Take
Appropriate oat rudiment, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 2：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 48h, arbitrarily select 5 seeds and measure rudiment length with ruler.Take
Appropriate oat rudiment, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 3：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 72h, arbitrarily select 5 seeds and measure rudiment length with ruler.Take
Appropriate oat rudiment, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 4：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 96h, arbitrarily select 5 seeds and measure rudiment length with ruler.Take
Appropriate oat rudiment, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 5：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 120h, arbitrarily select 5 seeds and measure rudiment length with ruler.
Appropriate oat rudiment is taken, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 6：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 144h, arbitrarily select 5 seeds and measure rudiment length with ruler.
Appropriate oat rudiment is taken, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 7：The preparation of oat rudiment extract
Oat seed removes the seed swum on the water surface, only with the seed for being deposited in the bottom with after purification water washing.Sprout
Budling part is as follows：Temperature is 20 ± 5 DEG C, relative humidity 80%, rudiment under dark conditions, during which avoids seed dried-up, persistently carries
For the purified water moisture enough to seed and nutrition.After rudiment 168h, arbitrarily select 5 seeds and measure rudiment length with ruler.
Appropriate oat rudiment is taken, after (50 DEG C) dryings of air drier, with 10 times of 70% ethanol of amount (volumetric concentration), normal temperature (25 ± 5
DEG C) ultrasonic extraction 3h, filter paper (HYUNDAI No.53) filtering, 45 DEG C of decompressions volatilize solvent, obtain oat rudiment extract (powder
Last shape).
Embodiment 8：Oat extract and oat rudiment extract are alleviated to be tested the effect of stimulation
Lauryl sodium sulfate (Sodium lauryl sulfate, SLS) is used as anion surfactant, is a kind of
Representative skin irritatin material, after it is combined with cell membrane, cell metabolism can be suppressed and destroy cell membrane, cause skin
Abnormal response.The surfactant can destroy the barrier function of cuticula, make it easier to skin permeation, when stimulant passes through
Cuticula reaches cortical tissue, changes and is balanced inside cell membrane, and cell proliferation and differentiation have influence, induce inflammatory mediator
Release, so as to promote cell degeneration, inducing cell death.On this basis, can be used for assessing oat using SLS processing samples
And its effect of the rudiment extract to cell viability, and analyze its anti-inflammatory efficiency.
DMEM culture mediums of the Human keratinocytes HaCaT (German cancer research institute DKFZ is provided) containing 10%FBS, 37
DEG C, in the insulating box of 5% carbon dioxide, with 1.5 × 104The concentration in/hole is divided in 96 orifice plates, after cultivating 24h, removes culture
Base, after PBS washings, the cell of starvation is made of the DMEM culture mediums without FBS.Second day SLS with 20ug/mL and suitable
When the sample treatment of concentration, 24h is cultivated.The WST-1 reagents of 10 times of dilutions, after each hole adds 100 μ L, training are added in culture medium
2h is supported, absorbance A is determined at 450nm by ELISA reader (Thermo, 51119300), is calculated according to formula (1) each
Embodiment sample is to the dead inhibiting rate of epidermal cell.
Cell death inhibiting rate (%)=(ASample-ASLS)/(AControl-ASLS) * 100% formula (1)
As seen from the experiment, 35.2%HaCaT cell deaths can be caused after SLS processing, and under different experiments concentration
Comparative example and the extract-treated of embodiment 1~7 after cell and SLS control groups significant difference (P ＜ 0.01), i.e. swallow is presented
The epidermal cell death efficiency that wheat and different oat rudiment extracts are induced SLS is respectively provided with certain inhibitory action, and presents
A certain amount imitates relation.Wherein,
The extract of embodiment 1~3 suppresses effect under high concentration (200 μ g/mL) to the epidermal cell death efficiency of SLS inductions
Fruit is better than comparative example extract, and the inhibition of the especially extract of embodiment 1 is optimal, and up to 77.20%.Illustrate, oat
And oat rudiment extract is respectively provided with preferable inhibition to the epidermal cell death that SLS is induced, and can alleviate skin irritatin,
The effect that the oat rudiment extract especially sprouted 1~3 day is alleviated epidermal cell and stimulated will be significantly better than the oat not sprouted
Extract.
Table 1：The inhibition for the epidermal cell death efficiency that different embodiment extracts are induced SLS
Note：In table, * represents T-test data statistic analysis, * P<0.05, otherness is notable；**P<0.01, otherness is non-
Chang Xianzhu；***P<0.001, otherness is extremely notable.Similarly hereinafter.
Embodiment 9：The effect of oat and oat rudiment extract alleviate itch is tested
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP) can cause pruitus as vasodilator, and have with the order of severity of dermatitis closely related；
Bradykinin (BK) is a kind of peptide matters for exciting itch, can increase the permeability of blood vessel dilatation and blood vessel.Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and bradykinin
Not only promote the inflammatory factors such as generation TNF-α, IL-1 β, IL-6, IL-8, also promote to excite the release of the histamine of itch, destroy
Skin barrier.Skin Cell and immunocyte can promote to secrete IL-6 when by outside stimulus such as Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 or bradykinin effect
And the inflammatory factor such as IL-8, so as to trigger inflammation and itch phenomenon.On this basis, this experimental study oat and its rudiment carry
Inhibitory action of the thing to the SP and BK IL-6 induced and IL-8 generations is taken, so as to confirm that it alleviates the efficiency of itch.
Normal human fibroblast NHF (is provided) vaccine inoculation in culture dish bottom by LONZA, with containing penicillin
(100IU/mL) and streptomysin (100 μ g/mL), replenishers (Supplement) (insulin 0.1%, rhFGF-B 0.1%, GA-
1000 0.1%, FBS 2%) fibroblast culture medium (FBM), at 37 DEG C, containing 5%CO2Insulating box in cultivate, with
1.5×104The concentration in/hole is divided in 48 orifice plates, cultivates 24h, and starvation then is made with the FBM culture mediums without Supplement
The cell of state.Second day embodiment sample with 500nM SP and debita spissitudo handles and cultivates 5h, or with 10nM BK and
The embodiment sample processing of debita spissitudo simultaneously cultivates 24h.Entered using R＆D System ELISA KIT (DY206, DY208)
After row experiment, absorbance A is determined at 450nm with ELISA reader, each embodiment sample is calculated according to formula (2) and (3)
To the inhibiting rate of the SP or BK IL-6 induced or IL-8 generations.
To the inhibiting rate (%) of IL-6 or the IL-8 generation of SP inductions
=(ASP–ASample)/(ASP–AControl) * 100% formula (2)
To the inhibiting rate (%) of IL-6 or the IL-8 generation of BK inductions
=(ABK–ASample)/(ABK–AControl) * 100% formula (3)
From table 2 and the experimental data of table 3, compared with negative control, SP stimulates fibroblast to cause IL-6
With IL-8 generation increase, wherein IL-6 growing amounts add 212.0%, and IL-8 growing amounts add 740.7%, and compare
IL-6, IL-8 generation that example and embodiment extract are induced SP have different inhibitory action.Under same concentrations effect, embodiment
The IL-6 generations that 1~6 extract is induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 suppress efficiency more than 60%, hence it is evident that better than comparative example extract；And phase
Under being acted on concentration, the IL-8 generations that embodiment 2-4 extracts are induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 have obvious suppression efficiency, significantly larger than compare
Compared with example extract.Test result indicates that oat rudiment extract more can effectively suppress than oat extract Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 induction into fibre
The generation of scrapie agent IL-6 and IL-8 in cell are tieed up, so as to effectively suppress itch, the oat especially sprouted 2~3 days sprouts
The inhibition of bud extract is optimal.
Table 2：The inhibition for the IL-6 generation efficiency that different embodiment extracts are induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Table 3：The inhibition for the IL-8 generation efficiency that different embodiment extracts are induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
From the experimental data of table 4, compared with negative control, by bradykinin stimulate fibroblast can cause IL-6 and
The growing amount that IL-8 generation increase, wherein IL-6 growing amount add 1045.3%, IL-8 adds 524.9%；And compare
Then have the function that compared with IL-6, IL-8 generation that example and different embodiment extracts are induced bradykinin different.Same concentrations are made
Under, the inhibitory action that comparative example extract generates to IL-6 or IL-8 is very weak or unrestraint acts on, and comparative example 2 and comparative example
It is respectively 51.72% and 42.25% that 3 extracts, which induce BK IL-6 generation inhibiting rate, induces BK IL-8 generation to suppress
Rate is respectively 12.98%, 4.88%.Test result indicates that the oat rudiment extract sprouted 2~3 days can significantly suppress
Scrapie agent IL-6 and IL-8 generation in the fibroblast of bradykinin induction, so as to effectively suppress itch, and significantly
Relieving itching better than oat extract acts on.
Shown by the studies above, IL-6, IL-8 that oat rudiment extract is induced Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and bradykinin generation have
Efficiency is significantly inhibited, and is substantially better than the oat extract of comparable sodium effect, especially sprouts the oat rudiment of 2~3 days
Extract has optimal suppression itch efficiency.
Table 4：The inhibition for IL-6 and IL-8 the generation efficiency that different embodiment extracts are induced bradykinin
Shown by embodiment 8-9 laboratory test results, small in identical activity compared with oat extract, oat
The oat rudiment extract that rudiment is especially sprouted 2~3 days has the epidermal cell of more significant SLS inductions is dead to suppress effect
Can, and can more effectively suppress by the generation of the scrapie agent such as Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 or the IL-6 and IL-8 of bradykinin induction, so as to more
Alleviate skin irritatin, mitigation well or suppress pruitus.If oat rudiment extract is applied into allergic skin external preparation,
The effect different from oat extract will be obtained.
The oat rudiment extract prepared in Example 1-7 is used for the preparation of skin preparations for extenal use.The skin preparations for extenal use
Preferably cosmetic composition, such as toner, Essence, creams etc..The oat rudiment extract is in skin preparations for extenal use
Percentage by weight be 0.0001%-20% (w/w).Preferable percentage by weight is 0.001%-10% (w/w).More preferably
Percentage by weight is 0.001%-5% (w/w).Most preferred percentage by weight is 0.01%-5% (w/w).
It is the embodiment of concrete application of the oat rudiment extract in skin preparations for extenal use below, and its these formulations are matched somebody with somebody
Side and preparation method."-" represents no added in following table.
Embodiment 10：The preparation of face cream
Embodiment 11：The preparation of emulsion
Embodiment 12：The preparation of gel
Embodiment 13：The preparation of toner
Embodiment 14：The preparation of Essence
Embodiment 15：The preparation of facial mask
Embodiment 16：The preparation of eye cream
Embodiment 17：The preparation of aerosol (cleaning bubble)
Embodiment 18：The preparation of spraying
Embodiment 19：The preparation of shower cream
Embodiment 20：The preparation of mildy wash
Claims (10)
1. a kind of preparation method of oat rudiment extract, the described method comprises the following steps：
A) oat seed is provided；
B) sprout, rudiment 1-7 days, obtains oat rudiment respectively；
C) heated-air drying, normal temperature ultrasonic extraction；
D) extract solution obtained in step c) is filtered；
E) filtrate decompression obtained in step d) is concentrated, volatilizes solvent, obtain oat rudiment extract.
2. the method as described in claim 1, it is characterised in that the step a) includes washing oat seed, removes floating
Seed.
3. the method as described in claim 1, it is characterised in that at a temperature of the step b) is included in 15-25 DEG C, 70-
Under 90% relative humidity, carried out under dark conditions.
4. method as claimed in claim 3, it is characterised in that the step b) sprouts 2-3 days.
5. the method as described in claim 1, it is characterised in that the step c) uses volumetric concentration 60-80% ethanol, preferably
70% ethanol extracts.
6. the oat rudiment extract that the method as described in claim any one of 1-5 is prepared.
7. application of the oat rudiment extract as claimed in claim 6 in skin irritatin is alleviated.
8. application of the oat rudiment extract as claimed in claim 6 in pruitus is alleviated.
9. a kind of skin preparations for extenal use, it includes oat rudiment extract as claimed in claim 6.
10. skin preparation composition for external use as claimed in claim 9, it is characterised in that the oat rudiment extract is outside skin
It is 0.0001%-20% (w/w) with the percentage by weight in agent, preferable percentage by weight is 0.001%-10% (w/w), more
Preferable percentage by weight is 0.001%-5% (w/w), and most preferred percentage by weight is 0.01%-5% (w/w).
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| KR20220077364A (en) * | 2020-12-02 | 2022-06-09 | 학교법인 송원대학교 | Extracting method of phenol compounds and flavonoid from oat sprouts |
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| KR20220077364A (en) * | 2020-12-02 | 2022-06-09 | 학교법인 송원대학교 | Extracting method of phenol compounds and flavonoid from oat sprouts |
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