CN107412031A - Dermatologic preparation composition containing orange peel element - Google Patents
Dermatologic preparation composition containing orange peel element Download PDFInfo
- Publication number
- CN107412031A CN107412031A CN201710166759.0A CN201710166759A CN107412031A CN 107412031 A CN107412031 A CN 107412031A CN 201710166759 A CN201710166759 A CN 201710166759A CN 107412031 A CN107412031 A CN 107412031A
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- CN
- China
- Prior art keywords
- composition
- orange peel
- green
- upper liquid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of containing Dermatologic preparation composition of the orange peel element as active ingredient.Also, the present invention provides a kind of Dermatologic preparation composition containing orange peel element and EGCG.Also, the present invention provides a kind of Dermatologic preparation composition of the citrus bark extract as active ingredient that will contain orange peel element.Also, present invention offer is a kind of in the citrus bark extract containing orange peel element, further includes the Dermatologic preparation composition of the green-tea extract containing EGCG.The composition of the present invention has excellent antioxidant effect, can be used as cosmetic composition, medicine or health food composition.Also, the composition of the present invention also has the excellent effect for preventing erythema, improving the colour of skin, preventing skin aging.
Description
The korean patent application No.KR 10-2011-0136181 and 2012 submitted this application claims on December 16th, 2011
The priority for the korean patent application NO.KR 10-2012-0146540 that on December 14, in submits；The application is in December, 2012
The Chinese patent application No.201280061424.8 submitted for 17th divisional application.
Technical field
The present invention relates to a kind of Dermatologic preparation composition containing orange peel element.Also, the invention further relates to one kind to contain
The skin preparations for extenal use of orange peel element and Epigallo-catechin gallate (EGCG) (EGCG, Epigallocatechin gallate)
Composition.
Background technology
All aerobe bodies including the mankind can often produce active oxygen during energetic supersession is carried out using oxygen
Injury, and essentially the generation of active oxygen beyond self-defense ability is considered as adult disease recently, into
For such as arthritis, circulatory system obstacle, or even the cause of disease of a variety of diseases such as senile dementia.
Be typically considered the active oxygen of harmful oxygen, be most stable state triplet oxygen (3O2) raw in oxidation, reduction process
Into a heavy state oxygen, as superoxide anion (1O2 -) and hydrogen peroxide (H2O2), hydroxyl radical free radical (OH) etc. do not match
State the immune system such as free radical, its injury protein matter, DNA, enzyme or T cell the factor, so as to cause disease.
Therefore, people have carried out active research to antioxidant, so as to have found numerous antioxidants, such as：
The preventative antioxidant of enzyme, such as superoxide dismutase (superoxide dismutase), catalase
(catalase), the antioxidase such as glutathione peroxidase (glutathioneperoxidase)；Vitamin E, vitamin
C, the natural such as carotenoid (carotenoid), glutathione (Glutathione)；And tertiary butyl-4-hydroxy
Anisole (t-butyl-4-hydroxyanisole, BHA), dibutyl hydroxy toluene (3,5- (t-butyl) -4-
Hydroxytoluene, BHT) etc. synthetized oxidation preventive agent.However as the increase at age, defence of the antioxidase for active oxygen
Ability reduces, and synthetized oxidation preventive agent is found to have mutagens different in nature (mutage nicity) and toxicity, therefore there is an urgent need to
Develop a kind of natural safer, effect is stronger.Inventor has excellent antioxidation activity in screening
Natural goods during complete the present invention.
The content of the invention
The technical problem to be solved in the present invention
To solve the above problems, it is an object of the present invention to provide a kind of skin containing orange peel plain (tangeretin)
Preparation composition for external use；Or provide a kind of composition containing orange peel element and EGCG and with antioxidation activity.
Technical scheme
The present invention provides a kind of containing Dermatologic preparation composition of the orange peel element as active ingredient.Also, the present invention is also
A kind of Dermatologic preparation composition comprising orange peel element and EGCG is provided.Also, the present invention, which provides one kind, will contain orange peel
Dermatologic preparation composition of the extract as active ingredient, the citrus bark extract contain orange peel element.Also, the present invention carries
For a kind of in the citrus bark extract containing orange peel element, the skin preparations for extenal use of the green-tea extract containing EGCG is further included
Composition.
Beneficial effect
The antioxidant effect of the Dermatologic preparation composition of the present invention is very excellent, can be used as cosmetic composition, medicine
Or health food composition.Also, the composition of the present invention also has and excellent prevent erythema, improve the colour of skin, prevent
The effect of skin aging.
Brief description of the drawings
Fig. 1 represents to obtain the process chart of the citrus bark extract containing orange peel element.
Fig. 2 is represented to citrus bark extract, green-tea extract and vitamin C, and diphenyl is carried out according to different concentration
The absorbance of picryl phenylhydrazine (DPPH) measure.
Fig. 3 represents to use the antioxidant effect by determining DPPH when citrus bark extract, green-tea extract；And combination
The experimental result of synergy when citrus bark extract and green-tea extract.
Fig. 4 is the figure for the result of the test for representing orange peel element and EGCG anti-oxidant synergy.
Preferred forms
The Dermatologic preparation composition of the present invention contains orange peel element and is used as active ingredient.Also, the present invention relates to one kind to contain
There are orange peel element and EGCG Dermatologic preparation composition.Also, the present invention relates to one kind to contain citrus bark extract as effective
The Dermatologic preparation composition of composition, the citrus bark extract contain orange peel element.Also, the present invention relates to one kind to contain tangerine
In Pi Su citrus bark extract, the Dermatologic preparation composition of the green-tea extract containing EGCG is further included.
The Dermatologic preparation composition of the present invention contains citrus bark extract as active ingredient, the citrus bark extract
Contain orange peel element.Also, the invention further relates in the citrus bark extract containing orange peel element, further include and contain EGCG's
Green-tea extract, so as to provide a kind of Dermatologic preparation composition with antioxidation activity.
Hereinafter, it will be described the present invention.
The orange peel element used in the present invention is tangeritin class, has O- polymethoxyflavones (O-
Polymethoxylated flavones) structure.Polymethoxyflavone class is the feature of citrus in flavones (flavones) class
Property composition, almost do not have in other veterinary antibiotics, and its on flavonoids (flavonoid) substitute 5 methoxyl groups thing
Matter.Therefore, orange peel element is as shown in following chemical formula 1.
Chemical formula 1
The green-tea extract used in the present invention includes the catechins such as EGCG, and EGCG is the composition of tannic acid or polyphenol
Composition, there is very strong antioxidant effect, its structure is as shown in following chemical formula 2.
Chemical formula 2
In one embodiment of the invention, above-mentioned orange peel element can obtain from citrus bark extract.The present invention's is another
In embodiment, above-mentioned orange peel element can be included in the form of the citrus bark extract containing orange peel element.Above-mentioned citrus bark extract
It is the mixture containing a variety of serviceability compositions for the natural extract containing orange peel element.
In one embodiment of the invention, above-mentioned EGCG can obtain from green-tea extract.Another implementation of the present invention
In example, above-mentioned EGCG can be included in the form of the green-tea extract containing EGCG.Above-mentioned green-tea extract is to contain EGCG's
Natural extract, it is the mixture containing a variety of serviceability compositions.
In one embodiment of the invention, it can be used as said extracted thing and raw material be impregnated in organic solvent after extraction,
By the concentrate for filtering, depressurize and concentrating and obtaining.Also, it also can be used to re-start above-mentioned concentrate and dry and make
Standby preserved materialDecoction, tincture and liquid extract.Above-mentioned deposit is to utilize solvent, using cold soaking, infiltration
(percolation), any means such as hot dipping deposit to orange peel or green tea, heavy containing active ingredient so as to obtain
Product thing.Above-mentioned organic solvent may be selected from C1-C4Anhydrous or hydrous ethanol, acetone, ethyl acetate, chloroform, glycerine, propane diols with
And one or more of butanediol, it is not limited to this.
After above-mentioned orange peel can be dried by any means such as natural drying or force dryings, use is chopped up.
The present invention relates to a kind of Dermatologic preparation composition is used containing orange peel element as the anti-oxidant of active ingredient.Also,
The present invention relates to a kind of Dermatologic preparation composition is used containing orange peel element and the anti-oxidant of EGCG.Also, the present invention relates to one kind
Citrus bark extract will be contained and use Dermatologic preparation composition as the anti-oxidant of active ingredient, above-mentioned citrus bark extract contains
Orange peel element.Also, the present invention relates to a kind of in the citrus bark extract containing orange peel element, further include and contain the green of EGCG
Dermatologic preparation composition is used in the anti-oxidant of tea extraction.
The present invention's is anti-oxidant with Dermatologic preparation composition, and relative to the gross weight of composition, above-mentioned orange peel element contains
Amount can be 0.001-10 weight %.When above-mentioned orange peel cellulose content is less than 0.001 weight %, almost without antioxidant effect；And
During higher than 10 weight %, it is possible to spoiled the problem of waiting cosmetics denaturation occurs, is not easy to adjust the viscosity of State of cosmetics, and mistake
Amount may result in the stimulation to skin when using.
The anti-oxidant of the present invention is used in Dermatologic preparation composition, relative to the gross weight of composition, above-mentioned EGCG content
Can be 0.001-20 weight %.When above-mentioned EGCG content is less than 0.001 weight %, almost without antioxidant effect, and it is higher than
During 20 weight %, it is possible to spoiled the problem of waiting cosmetics denaturation occurs, is not easy to adjust the viscosity of State of cosmetics, and excessively make
Used time may result in the stimulation to skin, therefore be difficult to develop into State of cosmetics, and its production economy also reduces.
The anti-oxidant of the present invention is used in Dermatologic preparation composition, above-mentioned to contain orange peel relative to the gross weight of composition
The content of the citrus bark extract of element can be 0.001-10 weight %.When orange peel extractive content is less than 0.001 weight %,
Almost there is no antioxidant effect.
The anti-oxidant of the present invention is used in Dermatologic preparation composition, above-mentioned to contain EGCG relative to the gross weight of composition
The content of green-tea extract can be 0.001-99.9 weight %.When green-tea extract content is less than 0.001 weight %, almost
There is no antioxidant effect.
The anti-oxidant antioxidant effect with Dermatologic preparation composition of the present invention is in the orange peel extraction containing orange peel element
Become apparent in the composite extract of thing and green-tea extract containing EGCG.This is the orange peel contained by citrus bark extract
Caused by the synergy for the EGCG that element and green-tea extract contain.
Contain the skin preparations for extenal use group that is used to prevent erythema of the orange peel element as active ingredient the present invention relates to a kind of
Compound.Also, the present invention relates to it is a kind of containing orange peel element and EGCG be used for prevent the skin preparations for extenal use of erythema from combining
Thing.Also, the plain citrus bark extract of orange peel will be contained as active ingredient for preventing that skin is red the present invention relates to a kind of
The Dermatologic preparation composition of spot.Also, further wrapped in the citrus bark extract containing orange peel element the present invention relates to a kind of
The Dermatologic preparation composition for being used to prevent erythema containing the green-tea extract containing EGCG.
The present invention's is used to prevent in the Dermatologic preparation composition of erythema, relative to the gross weight of composition, on
It can be 0.001-10 weight % to state orange peel cellulose content.When above-mentioned orange peel cellulose content is less than 0.001 weight %, almost do not prevent
The effect of erythema, and when being higher than 10 weight %, stability and security to composition can not meet.From based on expense
From the point of view of in terms of effect, preferably included in above range.
The present invention's is used to prevent in the Dermatologic preparation composition of erythema, relative to the gross weight of composition, on
It can be 0.001-10 weight % to state EGCG content.When above-mentioned EGCG content is less than 0.001 weight %, erythema is not almost prevented
Effect；And when being higher than 10 weight %, it is possible to spoiled the problem of waiting cosmetics denaturation occurs, is not easy to adjust State of cosmetics
Viscosity, and the stimulation to skin is may result in when being excessively used.
The present invention's is used to prevent in the Dermatologic preparation composition of erythema, relative to the gross weight of composition, on
The content for stating the citrus bark extract containing orange peel element can be 0.001-10 weight %.When orange peel extractive content is less than
During 0.001 weight %, almost without antioxidant effect.
The present invention's is used to prevent in the Dermatologic preparation composition of erythema, relative to the gross weight of composition, on
The content for stating the green-tea extract containing EGCG can be 0.001-99.9 weight %.When green-tea extract content is less than 0.001 weight
When measuring %, the effect of erythema is not almost prevented.
The Dermatologic preparation composition for being used to prevent erythema of the present invention prevent the effect of erythema containing
Become apparent in the composite extract of the citrus bark extract of orange peel element and the green-tea extract containing EGCG.This is by citrus
Caused by the orange peel element that bark extract contains and the EGCG that green-tea extract contains synergy.
Contain the Dermatologic preparation composition that is used to improve the colour of skin of the orange peel element as active ingredient the present invention relates to a kind of.
Also, the present invention relates to a kind of Dermatologic preparation composition for being used to improve the colour of skin containing orange peel element and EGCG.Also, this hair
It is bright be related to it is a kind of will contain citrus bark extract as active ingredient be used for improve the Dermatologic preparation composition of the colour of skin, it is above-mentioned
Citrus bark extract contains orange peel element.Also, the present invention relates to a kind of in the citrus bark extract containing orange peel element, further
The Dermatologic preparation composition for being used to improve the colour of skin comprising the green-tea extract containing EGCG.
In the Dermatologic preparation composition for being used to improve of the present invention, relative to the gross weight of composition, above-mentioned orange peel element
Content can be 0.001-20 weight %.When above-mentioned orange peel cellulose content is less than 0.001 weight %, almost without the effect for improving the colour of skin
Fruit；And when being higher than 20 weight %, stability and security to composition can not meet.From the effect side based on expense
From the point of view of face, preferably included in above range.
It is above-mentioned relative to the gross weight of composition in the Dermatologic preparation composition for being used to improve the colour of skin of the present invention
EGCG content can be 0.01-20 weight %.When above-mentioned EGCG content is less than 0.01 weight %, almost without the effect for improving the colour of skin
Fruit；And when being higher than 20 weight %, stability and security to composition can not meet.In terms of the effect based on expense
From the point of view of, preferably included in above range.
It is above-mentioned to contain relative to the gross weight of composition in the Dermatologic preparation composition for being used to improve the colour of skin of the present invention
The content for having the citrus bark extract of orange peel element can be 0.001-10 weight %.When orange peel extractive content is less than 0.001 weight
When measuring %, almost without the effect for improving the colour of skin.
It is above-mentioned to contain relative to the gross weight of composition in the Dermatologic preparation composition for being used to improve the colour of skin of the present invention
The content for having EGCG green-tea extract can be 0.001-99.9 weight %.When green-tea extract content is less than 0.001 weight %
When, almost without the effect for improving the colour of skin.
The effect for being used to improve the improvement colour of skin of the Dermatologic preparation composition of the colour of skin of the present invention is containing orange peel element
Become apparent in the composite extract of citrus bark extract and green-tea extract containing EGCG.This is by citrus bark extract
Caused by the synergy for the EGCG that the orange peel element and green-tea extract contained contains.
Also, in one embodiment of the invention, above-mentioned composition not only have increase skin elasticity, improve wrinkle of skin,
Improve complexion, pore refining, alleviate skin irritatin, lifting homeostasis, fat-reducing, improvement atopy, antibacterial bacteriostatic, mistake
Quick, elastic, acne, regeneration, sebum, metabolin and cutin improvement, restrain skin and rectify effect, it may also be used for
Improve fat and glycosuria, it is not limited to this.
The generally outer all compositions for being used for skin are included according to the Dermatologic preparation composition of the present invention, such as can be to change
Cosmetic compositions, medicine or health food composition.
Cosmetic composition for example can based on cosmetics, makeup cosmetic, hair-dressing cosmetics, body apply some make up
Deng, its formulation is had no particular limits, can be according to the appropriate selection of purpose progress.
For example, above-mentioned cosmetic composition can be solution, suspension, emulsion, cream, gel, frost, emulsion, pulvis, perfume (or spice)
The formulations such as soap, the cleaning agent containing surfactant, oil, powder cream base, emulsion foundation cream, wax foundation and spray, but
It is not limited to that.More specifically, it can be soft and moist toner, nutrition toner, emulsion, body lotion, nourishing cream, massage
Frost, moisturiser, hand frost, Essence, eye cream, washing cream, face cleaning foam, face cleaning water, facial mask, gel, patch, oil-in-water (O/W)
The basic cosmetics such as type, Water-In-Oil (W/O) type；The color make-ups such as lipstick, sun screen or foundation cream；Shampoo, hair conditioner, body clean skin
The cleaning agents such as dew, toothpaste or gargle；Hair oil, gel or the hairspray such as this that rubs；Hair tonic preparation or hair dye etc.
The formulations such as cosmetic hair preparation composition.
Above-mentioned cosmetic composition contains the medium or matrix available for cosmetics.It can be the suitable institute locally used
There are formulation, such as solution, gel, solid or the anhydrous product of paste, the emulsion for disperseing oil phase in aqueous phase and obtaining, suspension
Liquid, microemulsion, microcapsules, microballoon or the form of ionic (liposome) and/or nonionic folliculus dispersant；Or
It can be provided in the form of frost, toner, emulsion, pulvis, ointment, spray or screening flaw rod.Above-mentioned composition can be according to this
It is prepared by field usual way.
When the formulation of the present invention is solution or emulsion, solvent, lytic agent or emulsification can be utilized as carrier components
Agent, such as can be water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzylalcohol, Ergol, propane diols, 1,3-BDO
Oil, fatty acid glyceride, the fatty acid ester of polyethylene glycol or sorbitan.
When the formulation of the present invention is suspension, the dilute of the liquid phases such as water, ethanol or propane diols can be used as carrier components
Release the suspending agents such as agent, the isooctadecanol of ethoxylation, polyoxyethylene sorbitan ester and Sorbitan ethoxylate, crystallite
Cellulose, inclined aluminium hydroxide Bentonite, agar glue, bassora gum etc..
When the formulation of the present invention is cream, frost or gel, animal oil, vegetable oil, wax, stone can be used as carrier components
Wax, starch, bassora gum, cellulose derivative, polyethylene glycol, silicone, bentonite, silica sand, talcum or zinc oxide etc..
When the formulation of the present invention is pulvis or spray, lactose, talcum, silica sand, hydrogen-oxygen can be used as carrier components
Change aluminium, calcium silicates or Silon, when especially formulation of the invention is spray, can further contain CFC, propane/
The propellant such as butane or dimethyl ether.
The formulation of the present invention for cleaning agent containing surfactant when, as carrier components can be used aliphatic alcohol sulfate,
Fatty alcohol ether sulphate, sulfosuccinic acid monoesters, isethionate, imidazolidine derivatives, N-methyltaurine, sarcosinate,
Fatty acid amide ether sulfate, alkyl amido betaine, fatty alcohol, fatty glyceride, fatty diglycollic amide, vegetable oil,
Lanolin derivative or fatty acid ethoxy glyceride etc..
In one embodiment of the invention, thickener is can further include in above-mentioned cosmetic composition.It may be included in this hair
Bright thickener is methylcellulose, carboxymethyl cellulose, carboxymethyl guanine, hydroxymethyl cellulose, hydroxy ethyl fiber
Element, carboxyl vinyl polymer, polyquaternium, cetostearyl alcohol, stearic acid, carrageenan etc., it preferably can be used and be selected from carboxylic first
One kind in base cellulose, carboxyl vinyl polymer, polyquaternium, most preferably carboxyl vinyl polymer.
In one embodiment of the invention, the cosmetic composition can be as needed containing appropriate various matrix and addition
Agent, the species and addition of its composition can be simply selected by inventor.As needed containing the additive for allowing to use, example
It such as can further include preservative commonly used in the art, pigment, additive composition.Specifically, preservative can be benzene
Oxyethanol (phenoxyethanol) or 1,2- hexylene glycol (1,2-Hexanediol) etc., pigment can be artificial flavors etc..
And, on the one hand, in one embodiment of the invention, cosmetic composition can contain selected from water soluble vitamin, oil
Soluble vitamin, macromolecule peptide, macromolecule polysaccharide, the composition of sphingolipid and marine algae extract.In addition, can also add
Gradation composition can be lubricant component, NMF, softening agent, surfactant, organic and inorganic pigment, organic powder, purple
Ultraviolet absorbers, preservative, bactericide, antioxidant, plant extracts, pH adjusting agent, ethanol, pigment, spices, blood flow promote
Agent, cooling agent, antiperspirant, pure water etc..
Also, also addible gradation composition is not limited to that, but the present invention can not be influenceed in above-mentioned each composition
Purpose and effect in the range of be used cooperatively.
In one embodiment of the invention, inorganic or organic carrier can be added into pharmaceutical composition, with solid, semisolid
Or the mode of the non-oral administration agent of the form of liquid phase is formulation.It is above-mentioned can non-oral administration preparation may be selected from a drops,
Percutaneous dosing type formulation in ointment, emulsion, gel, frost, patch, spray, suspending agent and emulsion, it is not limited to
This.
In Dermatologic preparation composition in each formulation, those skilled in the art can be according to the agent of other skin preparations for extenal use
Type or application target etc., composition and other compositions to the invention described above are selected and coordinated easily, and and its
His raw material is possible to when using simultaneously can generating function lifting effect.
Also, according to the present invention composition with pharmaceutical composition in use, can further contain preservative, stabilizer,
Hydrated agentEither the acceptable assistant such as emulsification promoter, the salt for adjusting osmotic pressure or buffer and its
His therapeutic utility, and formulation can be carried out in the form of a variety of oral or non-oral administrations according to usual way
Change.
The actual dosage of active ingredient should be according to the weight degree of symptom, the method for administration of selection, the age of object, property
Not, the related factor such as body weight and health status and determine.
The dosage of active ingredient is usually the scope of 0.001mg/kg/ days to 2000mg/kg/ days, be more highly preferred to
Dose is 0.5mg/kg/ days to 2.5mg/kg/ days.
Embodiment
Hereinafter, the present invention will be described in detail with reference to embodiments of the invention, comparative example and test example.People in the art
Member it will be appreciated that these merely to the present invention illustration that is described in more details and carries out, the scope of the present invention
It can't be limited by following embodiments, comparative example and test example.
The preparation of [reference example 1] citrus bark extract
After orange peel pure water, it is dried.It is sharp at ambient temperature after the orange peel for removing moisture removal is crushed
With cold soaking extraction method, active ingredient is extracted through 40-48 hours.The content of extraction carries out once mistake with 250 μm of purpose filter beds
After filter, by centrifuging, upper liquid is obtained.Afterwards again to above-mentioned upper liquid with 3 μm, 1 μm, 0.5 μm of purpose filter by suitable
Sequence is filtered.Add 1,3 butylene glycol (1,3-Butylene glycol) 10%, Phenoxyethanol (phenoxyethanol)
0.5%th, after Sensiva SC50 (Ethylhexylglycerin) 0.05%, then carried out with 0.2-0.3 μm of purpose filter
Filter, so as to obtain citrus bark extract.
The preparation of [reference example 2] green-tea extract
After green tea pure water, it is dried.It is sharp at ambient temperature after the green tea for removing moisture removal is crushed
With cold soaking extraction method, active ingredient is extracted through 40-48 hours.The content of extraction carries out once mistake with 250 μm of purpose filter beds
After filter, by centrifugal separation processes, upper liquid is obtained.Filtering to above-mentioned upper liquid with 3 μm, 1 μm, 0.5 μm mesh numbers again afterwards
Device is filtered in order.After adding 1,3-BDO 10%, Phenoxyethanol 0.5%, Sensiva SC50 0.05%, then use
0.2-0.3 μm of purpose filter is filtered, so as to obtain green-tea extract.
The preparation of [reference example 3] orange peel element
The orange peel element used in the present invention is purchased from Sigma-Aldrich (Sigma-Aldrich).
[reference example 4] EGCG preparation
The EGCG used in the present invention is purchased from Sigma-Aldrich (Sigma-Aldrich).
[test example 1] antioxidant effect is tested
To confirm the reference example 1-4 used in the present invention citrus bark extract, green-tea extract, orange peel element and EGCG
Antioxidant effect, used free radical, i.e. 1,1- diphenyl -2- picryls phenylhydrazine (1,1-Diphenyl-2-
picrylhydrazyl：DPPH is referred to as below).Also, antioxidant known in the art (vitamin C) has been used as sun
Property control group.
During in the DPPH of purple with polyphenoils qualitative response, hydrogen electronics can be received from polyphenoils, its color changes
Become, and the absorbance at 517nm is reduced.
Reference example 1-4 citrus bark extract, green-tea extract, orange peel element and EGCG and vitamin C, with what is determined
Concentration is dissolved in ethanol, adds it to 96 orifice plates, per the μ l of hole 10.The concentration for adding 190 μ L in each hole afterwards is 100 μM
DPPH solution, then preserved 30 minutes under the conditions of 37 DEG C.Determined afterwards using spectrophotometer (spectrophotometer)
Absorbance at 517nm, its result are as shown in table 1.Also, handled with citrus bark extract, green-tea extract and vitamin C
When absorbance (O.D) result figure 2 illustrates.
25ppm citruses bark extract is used alone, 5 μM of green-tea extracts are handled, and use 25ppm citruses simultaneously
The result of synergy and DPPH color changes when bark extract and 5 μM of green-tea extracts are handled, as shown in Figure 3.
Also, when orange peel element, 5 μM of EGCG processing are used alone and being handled using orange peel element and EGCG simultaneously
Absorbance and DPPH color changes, as shown in Figure 4.
Table 1
As shown in above-mentioned table 1 and Fig. 2, compared with not doing the control group of any processing, green-tea extract is used
Absorbance (O.D) value during EGCG is greatly reduced, and during use 200ppm orange peel element, more than 50% is about reduced, so as to understand
It has excellent antioxidant effect.Especially, when simultaneously using 5 μM of EGCG and orange peel element, absorbance reduce 80% with
On, it is known that it has excellent synergy, and Fig. 3 specifically illustrates this synergy.
[test example 2] erythema is tested
The adult healthy using 40 implements skin irritation test as object.Wherein suffer from psoriasis
(Psoriasis), the patient of acne (acne), eczema (eczema), other skin diseases etc., and pregnant woman, in nursing period women
Or just take contraceptive, the people of antihistamine is excluded in the selected of subject.
Above-mentioned reference example 1-4 is used as substances, the coating of substances is sealed at the back of subject
Patch test (closed patch test) is closed, coating amount is respectively 20 μ l/chamber, and (IQ chamber) is specific to test
The concentration of material is as described in Table 3.
Attach patch and remove patch after 24 hours, 30 minutes and 24 hours after removal are detected.The inspection of reaction
Survey is the standard according to table 2 below and carried out that it is from CTFA guides (1981) and Frosch＆Kligman (1979)
Examination criteria develop.Its testing result is as described in Table 3.
Table 2
Table 3
From the result of above-mentioned table 3, orange peel element or EGCG according to the present invention can be confirmed, stimulation is considerably less, and relatively makes
With green-tea extract and citrus bark extract phase ratio, it shows significantly reduced level.
[embodiment 1-4]
Use above-mentioned reference example 1-4, the cosmetic composition of the improvement colour of skin of composition of the preparation with table 4 below.It is (single
Position：Weight %)
Table 4
[test example 3] improves the evaluation of face's colour of skin
To confirm the improvement of skin complexion, tested using the healthy women 60 of 20-40 year as object, by this
A little people are divided into 6 groups, every group of 10 people.To each group of formulation based on embodiment 1-4, make subject that it is coated on into entire surface
Portion, daily coating 2 times, is applied 4 weeks altogether.The change of colorimeter (Minolta CM-3500d) measure colour brightness is used after 4 weeks
(△ L), so as to evaluate the degree for improving skin complexion.Its result is as shown in small table 5, and described numerical value is each wherein in table 5
The average value of group.
Table 5
| △ L values | |
| Embodiment 1 | 3.45 |
| Embodiment 2 | 4.05 |
| Embodiment 3 | 3.85 |
| Embodiment 4 | 4.43 |
In the result of above-mentioned table 5, while comprising citrus bark extract and green-tea extract as active ingredient, or simultaneously
Formulation comprising orange peel element and EGCG, i.e. the △ L values of embodiment 2 and embodiment 4 are high.Therefore, can confirm to include orange peel simultaneously
The composition of extract and green-tea extract has the effect of very excellent bright color.In addition, according to simultaneously include EGCG
There is the result of excellent effect the most with the embodiment 4 of orange peel element, when can confirm to include above-mentioned all the components simultaneously, its effect can
It is further up.
Hereinafter, the formulation example according to cosmetic composition and pharmaceutical composition of the invention will be illustrated, but actually removed
Other formulations beyond following examples can also be applied, therefore it is merely to illustrate the present invention, rather than limit this hair
It is bright.
[formulation example 1] soft and moist toner (moisturizing lotion)
Composition according to described in table 6 below, soft and moist toner is prepared using usual way.
Table 6
[formulation example 2] nutrition toner (nutritional emulsions)
Composition according to described in table 7 below, nutrition toner is prepared using usual way.
Table 7
| Composition | Content (weight %) |
| Citrus bark extract | 1.0 |
| Green-tea extract | 1.0 |
| Glycerine | 3.0 |
| Butanediol | 3.0 |
| Propane diols | 3.0 |
| Carbopol | 0.1 |
| Beeswax | 4.0 |
| Polysorbate60 | 1.5 |
| Caprylic/capric triglyceride | 5.0 |
| Saualane | 5.0 |
| Sorbitan sesquioleate | 1.5 |
| Cetostearyl alcohol | 1.0 |
| Triethanolamine | 0.2 |
| Preservative, spices | In right amount |
| Pure water | Surplus |
| Altogether | 100 |
[formulation example 3] nourishing cream
Composition according to described in table 8 below, nourishing cream is prepared using usual way.
Table 8
[formulation example 4] massage cream
Composition according to described in table 9 below, massage cream is prepared using usual way.
Table 9
| Composition | Content (weight %) |
| Citrus bark extract | 1.0 |
| Green-tea extract | 1.0 |
| Glycerine | 8.0 |
| Butanediol | 3.0 |
| Atoleine | 45.0 |
| Beta glucan | 7.0 |
| Carbomer | 0.1 |
| Caprylic/capric triglyceride | 3.0 |
| Beeswax | 4.0 |
| Cetearyl glucan | 1.5 |
| Sorbitan sesquioleate | 0.9 |
| Paraffin | 1.5 |
| Preservative, pigment, spices | In right amount |
| Pure water | Surplus |
| Altogether | 100 |
[formulation example 5] facial mask
Composition according to described in table 10 below, facial mask is prepared using usual way.
Table 10
| Composition | Content (weight %) |
| Citrus bark extract | 1.0 |
| Green-tea extract | 1.0 |
| Glycerine | 4.0 |
| Polyvinyl alcohol | 15.0 |
| Hyaluronan extraction thing | 5.0 |
| Beta glucan | 7.0 |
| Allantoin | 0.1 |
| Nonylplenyl ether | 0.4 |
| Polysorbate60 | 1.2 |
| Ethanol preservative | In right amount |
| Preservative, spices | In right amount |
| Pure water | Surplus |
| Altogether | 100 |
Medicament (patch) is locally administered in [formulation example 6]
According to the composition described in table 1 below 1, patch is prepared using usual way.
Table 11
People in the art can be foundation according to the above, in scope of the invention, can carry out it is a variety of application and
Deformation.
More than, the characteristic of the present invention is described in detail, the technical staff with the usual knowledge in this area can
It is only preferred aspect to know these specific technological means, and the scope of the present invention is simultaneously only limitted to this.Therefore, substantive model of the invention
Enclosing can be limited by appended claims and its equivalent.
Industrial applicibility
The Dermatologic preparation composition of the present invention due to excellent antioxidant effect, available for cosmetic composition,
Medicine or health food composition.Also, the composition of the present invention also have it is excellent prevent erythema, improve the colour of skin,
Prevent the effect of skin aging.
Claims (11)
- A kind of 1. skin preparations for extenal use cosmetic composition, it is characterised in that its contain comprising orange peel element citrus bark extract and The mixture of green-tea extract comprising EGCG (EGCG) as active ingredient,Wherein, relative to composition total weight, the content of the citrus bark extract containing orange peel element is 0.001-10 weights % is measured, andWherein, relative to composition total weight, the content of the green-tea extract containing EGCG is 0.001-99.9 weight %.
- 2. skin preparations for extenal use cosmetic composition according to claim 1, wherein, it is anti-oxidant that the composition is used for skin Or improve skin complexion.
- 3. skin preparations for extenal use cosmetic composition according to claim 2,When the cosmetic composition is anti-oxidant for skin,Wherein, the concentration of the citrus bark extract in the composition is 5 μM, and the green-tea extract is in the combination Concentration in thing is 25ppm-200ppm.
- 4. skin preparations for extenal use cosmetic composition according to claim 2,When the cosmetic composition is used to improve skin complexion,Wherein, the content of the citrus bark extract in the composition is 0.5 weight %, and the green-tea extract is in institute It is 0.5 weight % to state the content in composition.
- 5. skin preparations for extenal use cosmetic composition according to claim 1,The wherein described citrus bark extract containing orange peel element is made by the preparation method comprised the steps：By orange peel pure water and drying, after the orange peel for removing moisture removal is crushed, carried at ambient temperature using cold soaking Follow the example of, active ingredient is extracted through 40-48 hours；After the content of extraction carries out first time filtering with 250 μm of purpose filter beds, lead to Centrifugation is crossed, collects upper liquid；The upper liquid of collection is filtered in order with 3 μm, 1 μm, 0.5 μm of purpose filter； 1,3 butylene glycol, 0.5% Phenoxyethanol and 0.05% Sensiva SC50 of addition 10% into upper liquid；To gained Upper liquid is filtered with 0.2-0.3 μm of purpose filter, so as to obtain citrus bark extract；AndThe wherein described green-tea extract containing EGCG is made by the preparation method comprised the steps：By green tea pure water and drying, after the green tea for removing moisture removal is crushed, carried at ambient temperature using cold soaking Follow the example of, active ingredient is extracted through 40-48 hours；After the content of extraction carries out first time filtering with 250 μm of purpose filter beds, lead to Centrifugation is crossed, collects upper liquid；The upper liquid of collection is filtered in order with 3 μm, 1 μm, 0.5 μm of purpose filter； 1,3 butylene glycol, 0.5% Phenoxyethanol and 0.05% Sensiva SC50 of addition 10% into upper liquid；To gained Upper liquid is filtered with 0.2-0.3 μm of purpose filter, so as to obtain green-tea extract.
- 6. the mixture of the citrus bark extract containing orange peel element and the green-tea extract containing EGCG (EGCG) is preparing skin The application of external preparation cosmetic composition.
- 7. application according to claim 6,Wherein described cosmetic composition be used for skin it is anti-oxidant or improve skin complexion.
- 8. application according to claim 6,Wherein, the institute of 0.001-10 weight % amount is included relative to the gross weight of the composition, the cosmetic composition The citrus bark extract containing orange peel element is stated, and relative to the gross weight of the composition, includes 0.001-99.9 weight %'s The green-tea extract containing EGCG of amount.
- 9. application according to claim 7,When the cosmetic composition is anti-oxidant for skin,The concentration of the citrus bark extract in the composition is 5 μM, and the green-tea extract is in the composition Concentration be 25ppm-200ppm.
- 10. application according to claim 7,When the cosmetic composition is used to improve skin complexion,Wherein, the content of the citrus bark extract in the composition is 0.5 weight %, and the green-tea extract Content in the composition is 0.5 weight %.
- 11. application according to claim 6,Wherein, the citrus bark extract containing orange peel element is made by the preparation method comprised the steps：By orange peel pure water and drying, after the orange peel for removing moisture removal is crushed, carried at ambient temperature using cold soaking Follow the example of, active ingredient is extracted through 40-48 hours；After the content of extraction carries out first time filtering with 250 μm of purpose filter beds, lead to Centrifugation is crossed, collects upper liquid；The upper liquid of collection is filtered in order with 3 μm, 1 μm, 0.5 μm of purpose filter； 1,3 butylene glycol, 0.5% Phenoxyethanol and 0.05% Sensiva SC50 of addition 10% into upper liquid；To gained Upper liquid is filtered with 0.2-0.3 μm of purpose filter, so as to obtain citrus bark extract；AndThe wherein described green-tea extract containing EGCG is made by the preparation method comprised the steps：By green tea pure water and drying, after the green tea for removing moisture removal is crushed, carried at ambient temperature using cold soaking Follow the example of, active ingredient is extracted through 40-48 hours；After the content of extraction carries out first time filtering with 250 μm of purpose filter beds, lead to Centrifugation is crossed, collects upper liquid；The upper liquid of collection is filtered in order with 3 μm, 1 μm, 0.5 μm of purpose filter； 1,3 butylene glycol, 0.5% Phenoxyethanol and 0.05% Sensiva SC50 of addition 10% into upper liquid；To gained Upper liquid is filtered with 0.2-0.3 μm of purpose filter, so as to obtain green-tea extract.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20110136181 | 2011-12-16 | ||
| KR10-2011-0136181 | 2011-12-16 | ||
| KR10-2012-0146540 | 2012-12-14 | ||
| KR1020120146540A KR102142311B1 (en) | 2011-12-16 | 2012-12-14 | Skin external composition comprising tangeretin |
| CN201280061424.8A CN103987385A (en) | 2011-12-16 | 2012-12-17 | Composition containing tangeretin for external application to the skin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280061424.8A Division CN103987385A (en) | 2011-12-16 | 2012-12-17 | Composition containing tangeretin for external application to the skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107412031A true CN107412031A (en) | 2017-12-01 |
| CN107412031B CN107412031B (en) | 2021-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710166759.0A Active CN107412031B (en) | 2011-12-16 | 2012-12-17 | Skin external composition containing hesperetin |
| CN201280061424.8A Pending CN103987385A (en) | 2011-12-16 | 2012-12-17 | Composition containing tangeretin for external application to the skin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201280061424.8A Pending CN103987385A (en) | 2011-12-16 | 2012-12-17 | Composition containing tangeretin for external application to the skin |
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| Country | Link |
|---|---|
| KR (1) | KR102142311B1 (en) |
| CN (2) | CN107412031B (en) |
| SG (2) | SG10201604847SA (en) |
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| KR20130088912A (en) * | 2012-01-31 | 2013-08-09 | (주)아모레퍼시픽 | Skin external composition containing tangeretin and egcg |
| TWI743349B (en) * | 2017-04-03 | 2021-10-21 | 大江生醫股份有限公司 | Composition comprising plant extracts and the use thereof for promoting the secretion of testosterone |
| CN108653478A (en) * | 2017-09-06 | 2018-10-16 | 四川云想科技有限公司 | A kind of antibacterial anti-inflammatory externally-used embrocation and its preparation method and application |
| KR102152584B1 (en) * | 2017-11-06 | 2020-09-08 | (주)아모레퍼시픽 | cosmetic composition for skin aging and moisturizing including extract of Jejudo hydrangea |
| CN108464949B (en) * | 2018-05-03 | 2021-04-20 | 上海璞萃生物科技有限公司 | Antioxidant whitening composition and application thereof |
| CN110833119A (en) * | 2019-10-30 | 2020-02-25 | 李佳璘 | Application of citrus fruit extract in livestock breeding and preparation method thereof |
| WO2021097025A1 (en) * | 2019-11-15 | 2021-05-20 | Dupont Nutrition Biosciences Aps | Process for reducing oxidation of a foodstuff and related compositions |
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- 2012-12-14 KR KR1020120146540A patent/KR102142311B1/en active IP Right Grant
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- 2012-12-17 SG SG10201604847SA patent/SG10201604847SA/en unknown
- 2012-12-17 SG SG11201402849PA patent/SG11201402849PA/en unknown
- 2012-12-17 CN CN201280061424.8A patent/CN103987385A/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| SG11201402849PA (en) | 2014-10-30 |
| SG10201604847SA (en) | 2016-07-28 |
| KR102142311B1 (en) | 2020-08-10 |
| CN107412031B (en) | 2021-01-05 |
| KR20130069512A (en) | 2013-06-26 |
| CN103987385A (en) | 2014-08-13 |
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