CN106913495A - Profit maintenance skin essence dew and preparation method thereof - Google Patents

Profit maintenance skin essence dew and preparation method thereof Download PDF

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CN106913495A
CN106913495A CN201510979342.7A CN201510979342A CN106913495A CN 106913495 A CN106913495 A CN 106913495A CN 201510979342 A CN201510979342 A CN 201510979342A CN 106913495 A CN106913495 A CN 106913495A
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skin
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essence
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trehalose
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王景民
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Shanghai Jane Bio Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract

The present invention proposes the preparation method of profit maintenance skin essence dew.Wherein each component and mass fraction be:The present invention of dendrobium candidum extract 1% 10%, glycerin polyether 26 1% 8%, Paeonol 0.1% 0.25%, Sodium Hyaluronate 0.05% 0.1%, PCA sodium 0.5% 1.0%, trehalose 1% 3%, Gotu Kola P.E 0.1% 0.5%, Carbomer 0.05% 0.15%, ginkgo biloba p.e 0.1% 1.0%, acetylation Sodium Hyaluronate 0.005% 0.1%, Phenoxyethanol 0.06% 1.0% is a kind of Multifunctional skin care product; the water content of skin can be improved; antiallergic sense; reduce wrinkle, gloss skin.

Description

Profit maintenance skin essence dew and preparation method thereof
First, art
Skin care item
2nd, technical background
Essence skin care item, they also have the proprietary vocabulary generally summarized in English:ESSENCE.Compared to the imposing manner for playing " integrating multifarious favour " that " essence " is given out on literal, " ESSENCE ", more it is emphasised that element is substantially, is a kind of purer concept.Just as " ESSENCE " this word is illustrated, they are a kind of concentrations of active ingredient.Even if but on the premise of dense, but still remain easily absorbed advantage.Therefore the skin of women is worked as along with the growth at age, or stayed up late for a long time, be negligent of under " compressing " of the severe external environment such as care, when common skin care item cannot infiltrate into deep skin completely, essence can rely on concentration functional component to readily penetrate through the barrier of skin, the nutrition of abundance is sent to for aging skin in time, cell is given with newborn vigor and energy.
Toner, essence, face cream, emulsion in complete skin care step, often walk the value of its own uniqueness, play irreplaceable skin-care effect.Essence belongs to intensive care product, and main purpose is to provide the active component denseer than creams.This product is water quality Essence; by dendrobium candidum extract, glycerin polyether -26, Paeonol, Sodium Hyaluronate, PCA- sodium, trehalose, Gotu Kola P.E, Carbomer, ginkgo biloba p.e, acetylation Sodium Hyaluronate, Phenoxyethanol; without alcohol, pigment, essence; property is gentle and compatibility is splendid; can be used directly as Essence; also in may be added to that such as toner, emulsion, face cream, the product of facial mask quality; strengthen the skin effect of product, help the absorption of active ingredient and strengthen product moisturizing moisturizing power.
One, Herba Dendrobii extracts (DENDROBIUM CANDIDUM STEM EXTRACT) ingredient and its effect
The stem of noble dendrobium, as one of rare Chinese medicine, early in《Sheng Nong's herbal classic》In just it is on the books, be listed as top grade.《Compendium of Materia Medica》Speech:" custom side is cured mainly in wound most with qi-restoratives, and gas under eliminating impediment, tonifying five zang organs consumptive disease wins thin, strong the moon strengthening the essence;Thick stomach, mend in it is never sufficient, itch gas by skin heat symptoms caused by an exopathgen, it is weak to control man's waist pin, is good for sun, and the beneficial power of kidney tonifying strengthens the bone, warming the kidney, macrobiosis of making light of one's life by commiting suicide etc. ".《This prosperous record of analyzing mentally》Think:" stem of noble dendrobium, is renal drug, is lung medicine, is medicine for enterogastritis.《This warp》' strong the moon word of ' two, the complete full dose of foot." add:" itch gas by skin heat symptoms caused by an exopathgen, be Wen Zhehan;' it is weak that pin knee aches cold numbness ' is treated, is cold person's temperature, otherwise go out《This warp》Eliminating impediment, the end ... of qi-restoratives two must receive the benefit ... of eliminating impediment qi-restoratives ".Into book in before more than 1000 years《Taoist Scriptures》Honor its be first of " Chinese nine big celestial grass ".It can be seen that it can cure the disease, and can help, temperature, cold and applicable feature.Each medical book of successive dynasties ancient books has many brilliant idea to the understanding of the stem of noble dendrobium and application, and the heart, liver, spleen, lung, the disease of kidney the five internal organs all have application, and the prescription of the various application stem of noble dendrobium exceedes hundreds of.In brief, the stem of noble dendrobium tool nourishing the stomach to improve the production of body fluid, moisten the lung and relieve the cough, nourishing Yin and clearing heat, voiceless sound improving eyesight the effect of.Research to the stem of noble dendrobium in recent years is increasingly goed deep into, experiment finds that the dendrobium polysaccharide contained in the stem of noble dendrobium has high value, particularly in biological medicine and skin care field, dendrobium polysaccharide have nourish yin jin, raising be immunized, build up health, strengthening the spleen and stomach, protect liver cholagogic, clearind deficient heat, reduce blood sugar, suppress tumour, nourish skin, anti-aging the effects such as.The anti-aging effects of dendrobium polysaccharide are the most notable in numerous plant polyoses, and this result also progressively receives the accreditation of whole world scientist.
Polysaccharide is the main component of the stem of noble dendrobium, and water-soluble polysaccharide content is up to 22.7%.The stem of noble dendrobium of separate sources, the content of polysaccharide has differences, different cultivars, the Dendrobium officinale polysaccharide mass fraction difference of different physiological ages, the biennial annual > of > lifes in 3 years, polysaccharide content of dendrobium candidum to different harvest time is analyzed, and finds polyoses content winter > spring > autumn, > summer.Contain substantial amounts of amino acid in the stem of noble dendrobium, with aspartic acid, glutamic acid, glycine, based on valine and leucine, the 53.0% of contained total amino acid is accounted for, separately contains threonine, serine, alanine, cystine, methionine, isoleucine, lysine, histidine, arginine, proline, tyrosine.The stem of noble dendrobium contains the abundant dendrobine of effect, dendrobine is one kind of alkaloid, alkaloid is the important active ingredient of a class in Chinese herbal medicine, it is separated at present to be planted to more than 10000, wherein more than 80 kinds have been used for clinic, as the jamaicin in the coptis is used for anti-inflammation, ephedrine in Chinese ephedra is used to relieving asthma, reserpine in devilpepper is used to be depressured, vincristine in camptothecine in camplotheca acuminata and catharanthus roseus is used for antitumor, and there is the hyoscyamine in datura, henbane seed spasmolysis to conciliate effect of organophosphorus poisoning etc..Composition of alkaloids is the earliest compound for separating and carrying out structural confirmation in Dendrobium Sw.The pharmacological action of dendrobine is mainly manifested in the antitumor, effect such as brought down a fever to cardiovascular, intestines and stomach inhibitory action and analgesic.Research contains potassium, calcium, magnesium, manganese, zinc, copper using inductively coupled plasma mass spectrometry, the aas determination stem of noble dendrobium.Etc. various trace elements, it is found that germplasm and physiological age have a significant impact for the accumulation of metallic element.
Dendrobium polysaccharide has the effect for removing hydroxyl radical free radical and ultra-oxygen anion free radical, is remarkably improved superoxide dismutase, glutathione peroxidase activity in tissue, mda content is reduced, with obvious antioxidation activity.Dendrobium polysaccharide has the effect of stronger suppression DNA damage, and effect is significantly stronger than VC.Experiment isolated polysaccharide DCPP1a-1 from stem of noble dendrobium protocorm, and confirm that polysaccharide DCPP1a-1 can substantially suppress OH and O2, and the external generation for incubating and MDA being homogenized with the murine liver tissue of Fe2+, H2O2 induction can be reduced, suppress the generation of mouse hepatic mitochondria MDA.Contain several amino acids in the stem of noble dendrobium, wherein proline, glycine, leucine and lysine are the essential elements for constituting collagen, wrinkle and relaxation problem can preferably be improved by supplementing amino acid, contained abundant amino acid and dendrobium polysaccharide also have the effect for improving skin moisturizing power in the stem of noble dendrobium.
2nd, the characteristic of Paeonol (PAEONOL) and effect
King of the tree peony in China is described as spending, was once decided to be the national flower of the Qing Dynasty.In addition to important decoration function, also certain medical value.Tree peony root contains active component Paeonol, and Paeonol can suppress intracellular O2- free radicals and produce, and can make skin brightening, by fossil pigments Reduction fading in skin, the siltization that disappears spot;Paeonol is respectively to the minimum inhibitory concentration (MIC) of S. aureus L-forms, saliva of buccal cavity streptococcus, alpha streptococcus, Escherichia coli, Candida albicans, Pseudomonas aeruginosa:1∶25000、1∶25000、1∶25000、1∶2500、1∶10000、1∶5000.Also there is the effect such as anti-inflammatory, swelling and pain relieving, antiallergy, antibacterial, antiviral simultaneously.Show that it can suppress capillary permeability and increase additionally by clinical test, therefore the also effect with anti-inflammation detumescence.
3rd, (HYALURONIC ACID) characteristic of Sodium Hyaluronate and effect
In nature, hyaluronic acid is distributed widely in the various tissues of higher mammal.Present people are separated to hyaluronic acid from umbilical cord, skin, human serum, cockscomb, joint fluid, cartilago cranialis, vitreum, chicken embryo, human urine, sound astillen.It is similar in the HA contents and knuckle synovia in cockscomb with the hyaluronic acid contents highest in vitreum, joint fluid, umbilical cord in mammal body.Hyaluronic acid is combined with protein to be coexisted with other mucopolysaccharides, in vitreum and knuckle synovia, is existed with dissolved form;In cockscomb and umbilical cord, exist with gel form.Content of the hyaluronic acid in human body is about 18g or so, and vital effect is played in the physiological activity of human body.If the hyaluronic acid contents in the histoorgans such as articular cavity, blood vessel, heart, eye, brain decline, the diseases such as arthritis, artery sclerosis, pulse disorder and encephalatrophy are may result in.
The deficiency of hyaluronic acid in human body can be supplemented using the product containing hyaluronic acid, it is to avoid the skin problem such as tissue and the aging of cell, dry skin, dry line microgroove for causing by the scarcity of hyaluronic acid in human body.Delaying sanility, makes skin moisturizing smooth, soft and high resilience.
4th, the characteristic of trehalose (Trehalose) and effect
Trehalose is a kind of safe and reliable natural carbohydrate; to first be extracted in its ergot from rye by Wiggers within 1832; trehalose is with 1 by two glucose molecules; the nonreducing sugar that 1- glycosidic bonds are constituted; there are 3 kinds of isomers i.e. trehalose (α, α), isotrehalose (β, β) and neotrehalose (α; β), and to various bioactivators there is non-specific protective effect.Scientists find that desert plant leaf roll cypress is almost withered in arid, meet after water but can miraculously bring back to life;Acrophyta is brought back to life grass and can be resistant to ice and snow severe cold;Some insects are not freezed under the conditions of gently dried dehydration high and cold, high etc., are not thirst, are exactly the life miracle that their internal trehaloses are created.Therefore trehalose have the good reputation of " sugar of life " in scientific circles.Internal authority《It is natural》Magazine has once delivered the special text evaluated trehalose in July, 2000, the article pointed out:" for many life entities, the being and not being of trehalose, it is meant that life or death ".Trehalose has magical protective effect to organism; because trehalose can form the diaphragm of uniqueness in high temperature, high and cold, hyperosmosis and under drying the severe environmental conditions such as dehydration in cell surface; effectively protected protein matter molecule consistency is inactivated, so as to the life process and biological characteristic of the body that sustains life.Many adverse circumstances to external world show the species of outstanding degeneration-resistant tolerance, and all there is substantial amounts of trehalose in vivo with them has direct relation.And such as other carbohydrates of sucrose, glucose in nature, do not possess this function.
Trehalose has excellent water-retaining property, hygroscopicity, in serious dehydration, can replace the effect of moisture in cell.Trehalose can have biological preservation and intelligent moisture-keeping function concurrently with hyaluronic acid use in conjunction, complementary synergy, can effectively keep the water content of skin.Trehalose can remove the OH free radicals produced by α, β ray, cell DNA is not susceptible to mutation.Experimental study proves that the trehalose of 10mmol/kg can make living cells bear α, β ray of 4.3 times of normal dose.Trehalose has stabilization to polyphenoils " polyphenol ", so as to reduce the possibility that product goes wrong.Trehalose can also reduce the freezing point of water phase, so as to greatly improve product low-temperature stability.
5th, the characteristic of accumulated snow extract and application
Centella Centellaasialica's dries herb, also known as line grass, ground wire grass, husband's root etc..Tao Hongjing is said:This grass is gained the name with cold and cool, its property Great Cold, therefore named centella.First recorded in《Sheng Nong's herbal classic》, show that it has had long medicinal history in China.《Chinese Pharmacopoeia》From version in 1977, each version pharmacopeia was recorded later, its have it is clearing heat and detoxicating, detumescence dampness removing the effect of.Blood strangury, carbuncle sore tumefacting virus, injury from falling down are drenched for jaundice with damp-heat pathogen, heatstroke diarrhoea, sand.Gotu Kola P.E mainly contains substantial amounts of triterpenoid saponins, such as:Asiaticosid (asiaticoside), madecassoside (madecassoside), Brahmoside (brahmoside), Brahminoside (brahminoside), thankuniside (thankuniside), isothankuniside (isothankunside) and Si Lilanka centellas (centello2side), asiaticodiglycoside (asiaticodiglycoside) etc., pentacyclic triterpene saponin is, 45 volatile oil compositions of long-chain are identified in centella.What wherein content was higher has carypohyllene (caryophyllene), method Buddhist nun (farnesol), elemene (elemene), longifolene (longifolene) etc..In addition it has also been found that containing the compositions such as meso inositol, centellose, carrot hydro carbons, chlorophyll, kaempferol, cupreol, glutamic acid, aspartic acid, vitamin B1, alkaloid and tannin in centella.
By observing influence of the centella to fibroblast core collagen synthesis at hyperplastic scar and keloid, its synthesis that can suppress cell propagation and collagen is found.So as to illustrate centella can effectively Inhibiting proliferation scars and keloid formation, and be effectively improved established scar symptom and outward appearance.Centella can show the facilitation of cyclin and PCNA level at the 3rd day.Result shows that centella can promote collagen synthesis, the site of injury cell cycle is substantially shifted to an earlier date, and accelerates cell propagation, promotes the surface of a wound quickly to heal.The outstanding healing of wound of centella and scar repair, are the effects such as Asiaticoside has the internal collagen of promotion and angiocarpy to generate, stimulation granulation grows.Prevent wound infection from suppurating, shorten wound healing time, lower skin hardness and improve skin-nourishing, enhance metabolism.Centella can remarkably promote the synthesis of fibrocyte and collagen, resist the aging course of skin.Centella can promote the synthesis of collagen I and collagen III, promote the secretion of mucopolysaccharide, increase the water conservation degree of skin, and activation updates Skin Cell, skin releived, lifted and with reflecting feel;Centella has activation for fibroblast gene, strengthens the vigor of skin basal layer cell, keeps elasticity of skin and consolidation sense, smooths face's fine wrinkles.Contain asiatic acid and brahmic acid in centella, the active saponin of these triterpenes has certain antibacterial activity, can protect plant itself to resist the invasion and attack of yeast and mold.With obvious antiinflammatory action, the generation of proinflammatory medium is reduced, there is provided and skin itself barrier function is repaired, prevent and correct skin immunologic function disorder.Free radical activity, desalination melanin pigmentation can be suppressed, improved skin blood circulation, promoted skin absorption ability, update skin cell regeneration, help melanin metabolism, make the smooth delicacy of skin.
6th, the characteristic of ginkgo biloba p.e and effect
Ginkgo (Ginkgo biloba L.), is Ginkgoaceae, Ginkgo deciduous tree, alias maidenhair tree, etc..Ginkgo is most ancient Relict Plant in existing seed plant before several hundred million years now.All become extinct with the every other plant of guiding principle with it, be known as plant living fossil.
China is the unique ginkgo remnants area in the world and NATURAL DISTRIBUTION center, with abundant germ plasm resource.Since 1980's, research with scientific circles to active ingredient contained by ginkgo nut leaf, makes people gradually recognize the special medical care effect that ginkgo has, and promotes the numerous and confused plantation ginkgo of world many countries and area, accelerate ginkgo product development, Developing Ginkgo industry.It is from head to foot precious that domestic and international gingko resource develops ginkgo, gingko seedses gingko), contain the main pharmacodynamics compositions such as flavone compound, mushroom class compound and organic acid, alkyl phenol, alkyl phenolic acid, street body compound, leaf wax, sugar and various trace elements in ginkgo leaf and ginkgo seed coat, with medical treatment, health care and trophic function, at home and abroad it has been widely used.
Research finds that contained flavone component can hinder formation and calmness of the pigment in skin corium in ginkgo leaf, reach the effect of skin whitening and preventing and treating pigment patch.In addition to flavones, the trace element such as manganese, molybdenum in ginkgo leaf also can scavenging activated oxygen and suppression melanin growth.Glycosides displayed and flavonols in ginkgo leaf are all the street cleaners of free radical, can protect corium confluent monolayer cells, improve blood circulation, prevent cell to be oxidized and produce wrinkle.
3rd, technology introduction
With reference to above-mentioned data, the present invention proposes the preparation method of profit maintenance skin essence dew.
Wherein each component and mass fraction be:Dendrobium candidum extract -1%-10%, glycerin polyether -26-1%-8%, Paeonol -0.1%-0.25%, Sodium Hyaluronate -0.05%-0.1%, PCA- sodium -0.5%-1.0%, trehalose -1%-3%, Gotu Kola P.E -0.1%-0.5%, Carbomer -0.05%-0.15%, ginkgo biloba p.e -0.1%-1.0%, acetylation Sodium Hyaluronate -0.005%-0.1%, Phenoxyethanol -0.06%-1.0% embodiments:
Raw material sequence number Material name Addition % Adding purpose
1 Dendrobium candidum extract 1%-10% Anti-oxidant, moisturizing, maintenance
2 Glycerin polyether -26 1%-8% Moisturizing, solubilizer
3 Paeonol 0.1%-0.25% Antibacterial, antiallergy
4 Sodium Hyaluronate 0.05%-0.1% Efficient moisture-retention agent
5 PCA- sodium 0.5%-1.0% It is moisturizing, whitening, antistatic
6 Trehalose 1%-3% It is moisturizing, sun-proof, antifreeze
7 Gotu Kola P.E 0.1%-0.5% Compact, whitening, bleeding agent
8 Carbomer 0.05%-0.15% Thickener
9 Ginkgo biloba p.e 0.1%-1.0% Anti-oxidant, whitening, antioxidant
10 Acetylation Sodium Hyaluronate 0.005%-0.1% Efficient moisture-retention agent
11 Phenoxyethanol 0.06%-1.0% Preservative
12 Deionized water Add to 100% Filler
The preparation method of the profit maintenance skin essence dew of the present embodiment is according to following flow operations:
1., by the requirement in embodiment form, deionized water is placed in agitated kettle by accurate metering deionized water ratio, item by item by the raw material (sequence number of accurate metering:1st, 2 85 degree at the uniform velocity 12), 3,4,5,6,7,8,9,10, are heated with stirring in input agitated kettle.85 degree of stirrings of constant temperature, mixing speed is 1000RPM.
2. cooling water is connected, is lowered the temperature at a slow speed, and mixing speed is adjusted to 800RPM.
3. preservative (Phenoxyethanol) is added, mixing speed is adjusted to 600RPM, stirring is uniformly dispersed in body is expected to ensuring preservative (Phenoxyethanol) after being cooled to 45 degree.
4. it is cooled to 40 degree and stops stirring, is discharged after sampling detection.
Composition in embodiment is by obtaining profit maintenance skin essence dew of the invention after the preparation method, this product clear appearance is transparent, in mobility liquid, pH value is 5.5-7.0, with cold resistance, -5 DEG C to -10 DEG C preserve 24 hours, recover to shape no significant difference after normal room temperature, and product items organoleptic indicator, physical and chemical index, sanitary index meet national all standard.
4th, technical advantage
Without alcohol, pigment, essence, mineral oil, property is gentle, quality water profit is salubrious free of a burden using skin sense and compatibility is splendid, can be used directly as Essence, also may be added to that in such as toner, emulsion, face cream, the product of facial mask quality, strengthen the skin effect of product, product extract component containing various plants, composition proportion science, test indicate that effect is comprehensively reliable.Help the absorption of active ingredient and strengthen product moisturizing moisturizing power.
Product preparation section simplifies, and process time shortens, the problems such as being prevented effectively from because of composition of raw material inactivation caused by processing duration or aoxidize.
5th, effect statistics
One (skin elasticity test) of test:
Subject:Skin health, without skin medical history, non-allergic constitution meets subject's aspiration inclusion criteria.
Method of testing:Test tests CotometerMPA580 main frames using the skin elasticity of Germany Courage+Khazaka (German CK companies) manufactures, and test probe uses Reviscometer RV600 elastic fibrous tissues test probe, is averaged after testing five times.
Test scope:Cheek region at the upward 3cm foreheads region in place between the eyebrows center, the downward 2cm chin areas in lower lip middle, nose and pupil intersection or so.
Test index:Skin elasticity index R2, R5, R7 is better closer to the elasticity of 1 explanation skin.
Numbers illustrated:R2=Ua/Uf, R5=Ur/Ue, R7=Ur/Uf
Uf is the maximum tension value of skin
Ue is the tension values of skin when constant negative pressure is applied to latter 0.1 second on skin, the tension values of positioning elastic part.
After Ur is to cancel negative pressure, skin can restore to the original state rapidly state, while be divided into elastic portion score value Ur, that is, the cancel negative pressure 0.1 second recovery value of skin and visco-elastic portions value afterwards.
Ua is the recovery value of skin when adding negative pressure again from cancellation negative pressure to next time test skin surface.
Table 1 is profit maintenance skin essence dew test result table
Testing time/week R2 R5 R7
0 0.5026 0.4396 0.4521
1 0.6205 0.6185 0.5407
2 0.7184 0.7016 0.6740
3 0.8098 0.7983 0.7544
4 0.9045 0.8793 0.8296
Test mark understands according to more than, R2, R5, R7 numerical value substantially rise after being revealed first week using profit maintenance skin essence, to 4th week numerical value already close to 1, the skin elasticity index of subject has lifting very high, it can be seen that treasure's profit maintenance skin essence dew has functions that to increase skin elasticity, crease-resistant, anti-aging.
Two (routine use tests) of test
Subject:The people of subject 30, women, age between 25-61, skin health, without skin medical history, non-allergic constitution meets subject's aspiration inclusion criteria.
Method of testing:Respectively using profit maintenance skin essence dew, using effect is observed.
Application method:Appropriate profit maintenance skin essence dew uniform application is taken after daily morning and evening face cleaning in face skin, and is massaged into absorption, persistently using one month and record using effect, whether check and record has adverse reaction.
Table 2 is profit maintenance skin essence dew routine use effectiveness results mark
From above table, the present invention (profit maintenance skin essence dew) receives the accreditation of extensive subject, subject thinks profit maintenance skin essence dew good penetrability, easily absorbs, replenishing water and preserving moisture effect is good, effectively calm down microgroove, desalination wrinkle, delay skin aging and energy long-time moisturizing, increase skin elasticity, and skin gloss can be increased, skin is more glossy.Whole subjects illustrates profit maintenance skin essence dew property gently without allergy reflection, can be with long-term use.
Representative instance 1:Lee's women face is dark yellow, lax, the colour of skin is more black and skin is more sensitive within 36 years old, the colour of skin is obviously improved after persistently conserving skin essence dew using 4 weeks profits, facial radiance degree is significantly improved, lax skin also begins to compact,, also no longer as fragile before, the state of skin substantially improves for skin after exposing to the weather.
Representative instance 2:Women Cao's skin of face is extremely dry within 25 years old, and dry line is more, and face has more acne scar.Persistently had using skin after surrounding profit maintenance skin essence dew and be obviously improved, facial water content is obviously improved, and dry line has obvious improvement, and acne scar color is substantially desalinated.
Representative instance 3:45 years old Zheng's cutis laxas, and the colour of skin is more black, is persistently had using skin after surrounding profit maintenance skin essence dew and is obviously improved, skin substantially compacts, pale and glossy.Wrinkles on one's forehead, crow's feet and expression line have obvious desalination.
6th, application field
Cosmetics, skin care item.

Claims (2)

1. technical characteristic:Without alcohol, pigment, essence, mineral oil, property is gentle, quality water profit is salubrious free of a burden using skin sense and compatibility is splendid, can be used directly as Essence, also may be added to that in such as toner, emulsion, face cream, the product of facial mask quality, strengthen the skin effect of product, product extract component containing various plants, composition proportion science, test indicate that effect is comprehensively reliable.Help the absorption of active ingredient and strengthen product moisturizing moisturizing power.Product preparation section simplifies, and process time shortens, the problems such as being prevented effectively from because of composition of raw material inactivation caused by processing duration or aoxidize.
2. profit maintenance skin essence dew each component and mass fraction are:Dendrobium candidum extract -1%-10%, glycerin polyether -26-1%-8%, Paeonol -0.1%-0.25%, Sodium Hyaluronate -0.05%-0.1%, PCA- sodium -0.5%-1.0%, trehalose -1%-3%, Gotu Kola P.E -0.1%-0.5%, Carbomer -0.05%-0.15%, ginkgo biloba p.e -0.1%-1.0%, acetylation Sodium Hyaluronate -0.005%-0.1%, Phenoxyethanol -0.06%-1.0%.
CN201510979342.7A 2015-12-24 2015-12-24 Profit maintenance skin essence dew and preparation method thereof Pending CN106913495A (en)

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WO2021077320A1 (en) * 2019-10-23 2021-04-29 L'oreal Composition for caring for the skin
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CN111184678A (en) * 2020-03-05 2020-05-22 苏州知时生物科技有限公司 Soothing spray formula for sensitive skin and manufacturing process thereof

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