CN109568231A - It is a kind of can Red blood streak dispelling skin composition and its preparation method and application - Google Patents

Abstract

The invention discloses it is a kind of can Red blood streak dispelling skin composition, in the acceptable matrix of skin composition, following active component is included at least: the composite plant Red blood streak dispelling preparation constituted is compounded by Gotu Kola P.E, glycyrrhiza glabra root extract, mountainous region mugwort extract, narrow leaf blueberry berry extract, ginkgo biloba p.e, dog rose fruit oil；Vitamin P4；Avenabeta glucosan and Ectoin；Fat of Oromaius norvaehollandeae, rose hip oil and grape seed oil；N- palmityl hydroxy-proline cetyl；Fermentative brown rice filtrate and trehalose.The present invention discloses preparation methods and application.The skin cream that skin composition of the present invention and preparation method thereof is prepared can effectively repair skin because cutin is damaged telangiectasis, silting, the impaired red capillary formed, also have the superperformances such as property is mild, skin sense silk is sliding, pro-skin easily absorbs.

Description

It is a kind of can Red blood streak dispelling skin composition and its preparation method and application

Technical field

The present invention relates to a kind of shield skin compositions, and in particular to it is a kind of can Red blood streak dispelling skin composition and its preparation Methods and applications belong to cosmetic technical field.

Background technique

The common Crack cause of red capillary is that cutin is impaired, and capillary loses the natural protection of cuticula, for a long time by External environment stimulation leads to blood vessel dilatation, silting, is damaged.The congenital capillary position of face is than a kind of face caused by shallower Portion's phenomenon, skin is thin and sensitive, and face is redder when being subcooled, overheating, is excited, so that face is the master that red capillary phenomenon occurs Want position.Red blood trace on face patient facial region seems redder than general normal skin tone.People often claim plateau face or red apple, and some is only It is only that two sides cheekbone portion is rubescent, boundary is rounded, generally in silk the linear alignment.This skin is thin and sensitive, supercooling, overheat, mood Face is redder when exciting；It is also extremely sensitive to weather and environment, pollen dust mite, the irradiation of summer ultraviolet light, autumn after spring wind Season drying and winter cold etc. may all cause skin allergy and red capillary occur；Various foods, drug, metal, cosmetics waited Quick original is all likely to cause different degrees of red capillary.Serious person also will form deposition color spot, it is difficult to cure.It not only influences outer The beauty of table, can also cause shade to psychology, bring great inconvenience to normal life.

The formation of red blood trace on face is more complicated, can be broadly divided into two geneogenous and acquired day after tomorrow classes.It is congenital Including congenital Treatment of telangiectasia, facial mole property telangiectasis etc..Primary person is mostly congenital heredity, i.e., Someone once suffered from this disease in parent or family.Formation posteriority is mostly formed since various impairment factors act on.The table of skin Cortex is that capillary, the third layer spinous layer that the cytotrophy of epidermis is mainly derived from our skin epidermis do not provide , when acantholysis cell is impaired, itself supply nutritional capacity declines.We have repair ability by skin itself, at this moment skin corium Capillary is independently expanded upwards, helps acantholysis cell to provide nutrition, to form red capillary.The cytoclasis of epidermis is tighter Weight, the debatable time is longer, blood capillary proliferation migrates heavier, and red capillary is more serious.

Posteriority red capillary morbidity principal element has: corticoid drug is used for a long time in 1. parts, causes capillary Expansion, leads to thinning of skin, atrophy etc.；Telangiectasis is caused, thinning of skin, atrophy etc. are caused.2. improper aesthetic nursing Factor and changes skin and causes cutaneous immunisation if the destruction and hormone dependant telangiectasis of composition sour in skin care item rupture Power is fragile, remains epidermis using toxin such as some cosmetics containing heavy metal, causes sensitivity response, destroy cuticula, causes red The trace of blood；Often the upper face beauty parlor Zuo Xi nursing also results in blood vessel dilatation rupture, and doing cuticula polishing, photon delicate skin etc. causes Cuticula, which is damaged, causes red capillary.Skin is changed by beauty, because changing skin product mainly contains " benzoic acid ", repeatedly with " benzoic acid " Thin tender, fine and smooth face position is stimulated, the skin corium not being protected is externally exposed, receives the irradiation of intense UV rays It is caused；Skin long-term nutrition, allergy dehydration.Wing of nose nasal fossa is caused microfilament blood occur 3. external force improperly squeezes acne whelk etc. Pipe deformation.4. helminth such as acarid enters that corium causes skin contraction by hair follicle and face reddens.5. strong ultraviolet radiation Cuticula is destroyed, causes telangiectasia poor, causes red capillary；Such case is frequently not individually to lead to red capillary Reason usually plays the part of secondary role, thus the nursing of red blood trace on face should not be only dispel it is red, it is further noted that it is sun-proof, protect Wet, isolation, antiallergic etc. are many-sided to be combined；6. plateau high altitude localities skin anoxic, leads to increasing for erythrocyte number, causes hair Thin blood vessel dilatation rupture, capillary recycle unsmooth, angionecrosis because of anoxic；And cold district blood circulation is obstructed, blood vessel Wall stasis makes face that a rule red capillary be presented；Cold stimulation is air-dried, dust storm weather, and exposure in sunshine keeps capillary resistance to It has been more than normal range (NR) by property, telangiectasis is caused to rupture.7. other cause because of occupation, disease, personal bad habit etc. Red capillary illness.

The treatment of red capillary mainly improves the elasticity of facial capillary, restores the normal contraction and diastole function of blood vessel Can, reduce vasopermeability.Mainly there are the methods of living cells therapy, physiotherapy, chemotherapy to be treated at present.Living cells Therapy is to provide the cell that bio signal repairs skin epidermis by the albumen with very strong correlation bioactivity, gives epidermis Cells with nutrient, fine and close cuticula defense system is rebuild, to achieve the effect that treatment or improve red capillary.Physics is controlled Treatment is by using specific wavelength to skin exposure, absorption of two red capillarys to specific wavelength, to achieve the effect that dispel. The method mainly used has frequency multiplication Nd:YAG laser；varity pulse width VPW532；Semicontinuous laser；Pulsed dye Laser；Flash lamp pumped dye laser；Long pulse dye laser pulse dye laser PDL585；Copper vapor laser The physical methods such as (copper steam photodynamic therapy PDT) semicontinuous laser.Chemotherapy passes through chemistry Two specific absorption of the characteristics of product are to red capillary, to dispel red capillary.Chemicals mainly reduces vasopermeability.

The skin of red capillary is generally also more sensitive, also can choose some products for having effects that red capillary and repairing.It is special Not Jian Yi red capillary patient should usually be careful not to the food of the pungent stimulation of diet, no other than daily skin care item use It drinks, keeps sufficient sleep and good phychology that conditioning is gone to improve.Adhering to effectively improving improves and can repair comprehensively.

Red capillary degree can be from slightly to severe subdivision are as follows: is in dotted red capillary when skin damage 30%；Skin Impaired 50%, it is linear red capillary；Skin damage 70% is in netted red capillary；Skin damage 90% is in the form of sheets Red capillary.

Summary of the invention

To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of skin compositions of Red blood streak dispelling.

Skin composition of the present invention may include active constituent of the present invention and other of the present invention group Point, or be grouped as by these groups or be substantially grouped as by these groups, " being substantially grouped as by these groups " refers to this The invention skin composition can also include other components, as long as the other components will not change the present invention and be wanted significantly Ask the skin composition of protection or the basic characteristic of preparation method.

" skin care " of the present invention refers to improving the situation of skin, such as: enhancing skin elasticity, whitening, nti-freckle.

In addition, heretofore described " skin composition is acceptable " refers to that skin composition of the present invention is suitable For contacting with human skin, and toxicity, incompatibility, unstability and allergic reaction etc. will not be generated to human body.

In order to achieve the above objectives, the present invention uses following specific technical solution:

It is a kind of can Red blood streak dispelling skin composition, in the acceptable matrix of skin composition, include at least following work Property component, and the additional amount of the active component is in terms of skin composition total weight percent:

(1) composite plant Red blood streak dispelling preparation: by Gotu Kola P.E 0.05-0.5%, glycyrrhiza glabra root extract 0.05-0.5%, mountainous region mugwort extract 0.05-0.5%, narrow leaf blueberry berry extract 0.05-0.5%, ginkgo biloba p.e 0.05-0.5%, dog rose fruit oil 0.5-5.0% compounding are constituted；

(2) vitamin P4 0.1-1%；

(3) skin repair component: avenabeta glucosan 0.2-2.0% and Ectoin 0.1-3.0%；

(4) grease: fat of Oromaius norvaehollandeae 0.5-5.0%, rose hip oil 0.5-3.0% and grape seed oil 0.5-5.0%；

(5) N- palmityl hydroxy-proline cetyl 0.05-1.0%；

(6) moisturizing component: fermentative brown rice filtrate 1.0-15.0% and trehalose 0.5-3.0%.

In above-mentioned active component,

Composite plant Red blood streak dispelling preparation: there is stronger anti-inflammatory, anti-oxidant, antibacterial and soothe the skin multi-functional multiple Close galenical.The composite plant Red blood streak dispelling preparation MultiEx Rosanic of BIOSPECTRUM company, South Korea exploitation, contains Have Gotu Kola P.E, glycyrrhiza glabra root extract, mountainous region mugwort extract, narrow leaf blueberry berry extract, ginkgo biloba p.e, The substance of the oily six kinds of natural botanical sources of dog rose fruit.The main effective ingredient of Gotu Kola P.E kind is asiaticosid, is had Good curative effect has promotion Wound Healing.For treating wound, operation wound, burn, keloid and chorionitis.Treatment Because virus or bacterium caused by shingles zoster；Local leukocytosis, connective tissue rete vasculosum increase, and mucilage secretion increases, Fur hyperplasia accelerates, and plays the role of inhibiting skin ulcer.Gotu Kola P.E has calm work to rheumatism, arthritis in Chinese medicine With also having significant curative effect to blood vessel dilatation, anti-aging etc..Glycyrrhiza glabra root extract can go deep into inside skin and keep high work Property, it can inhibit the activity of tyrosinase, and can inhibit the activity of dopachrome interconversion and DHICA oxidizing ferment, be it is a kind of quickly, Efficiently, green whitening cosmetics additive has with SOD (superoxide dismutase) similar scavenging activated oxygen Ability has and Ability of antioxygen free radicals similar in vitamin E.Also have effects that prevent pachylosis and anti-inflammatory, antibacterial.Mountain Ground mugwort extract contains absinthin, Chinese mugwort Huang, absinthol etc..Chinese medicine be usually used in treat digestive system, worm, menstruation, corn, The diseases such as wart, acne, fever, cough, rheumatism, scurvy and oedema.Cowberry makees blueberry again, and cowberry contains ellagic acid, tan spends list Rather, the Multiple components such as the vitamin Cs such as folic acid, anthocyanin, flavonoids and B family vitamin, the expert of American Studies cowberry, Mao Rui Doctor and Japanese three professors Shi Yan, which study, confirms that cowberry fruit can increase the flexibility of capillary, can pure promotion vascular dilation And retractility, prevent angiorrhoxis；Antioxidant is provided, the free radical for making vascular sclerosis can be eliminated, prevention of arterial hardening is strengthened Capillary in other organ-tissues of body reaches each portion's organ vascular lesion of prevention.Glycosides displayed and flavones in ginkgo leaf Alcohol is all the street cleaner of free radical, can protect corium confluent monolayer cells, improves blood circulation, cell is prevented to be oxidized generation wrinkle. MultiEx Rosanic composite plant Red blood streak dispelling agent (detects free radical scavenging activity with DPPH method, dense by anti-oxidant Be essentially identical to same concentration VC effect when degree is 1%), it is anti-inflammatory that (the NF-B activity of LPS- induction, sends out after 1%Rosanic processing 40%) existing activity reduces, remove free radical and reduce the ROS& inflammatory factor for causing red capillary to be fallen ill, along with antibacterial and consolidate skin Skin barrier soothes the skin reduction water loss and reaches reduction red blood trace on face.

Vitamin P4: it is that there is stronger increase capillary resistance containing one kind, reduces capillary permeability Natural botanical source product.The agglutination that can inhibit blood platelet prevents thrombosis, at the same can fight 5 one hydroxytryptamines, Injury of blood vessel caused by bradykinin increases capillary resistance, reduces capillary permeability；It can prevent vasopermeability liter Oedema caused by height has significant protective effect to Acute ischemia rePerfusion.

Avenabeta glucosan and Ectoin: for one group of natural products with stronger repairing effect.Wherein, β-Portugal is poly- Sugar is formed by polysaccharide by the bond of glycosidic bond for D-Glucose monomer, and it is poly- naturally cannot to generate or synthesize Portugal in human body Sugar, obtaining this compound unique channel can only be by absorbing from outside.Such as Saccharomyces cerevisiae, mushroom, cereal, oat, barley, Wheat etc..It, which has human skin, promotes wound healing to alleviate inflammation, inhibits interior free yl, reinforces and maintain the water in skin The effects of dividing, adjusting anaphylaxis physical condition (low allergic constitution).Oat is water-soluble fibre (1,3/1,4) callose Abundant source, the influence to human health were widely studied at past 30 years.Avenabeta glucosan is to be present in oat A kind of non-starch polysaccharide of endosperm and gluten cell wall.With unique straight-chain molecular structure, good transdermal suction is imparted Performance is received, fibroblast is promoted to synthesize collagen, promotes wound healing, impaired skin is repaired, gives skin such as silk Moisten smooth sense of touch.And there is inhibition to the inflammatory cytokine such as prostaglandin E2 (PGE2) and IL-6 of ultraviolet radiation generation Effect.

Ectoin derives from high Halophiles (Halomonas Elongata), therefore also it is called " Facultative Halophiles extraction Liquid ".1985, for Professor Galinski in Egyptian desert discovery desert Halophiles * in high temperature, dry, strong UV irradiation was high Under saline environment, a kind of natural protective ingredient can be generated in cellulosa.Halophiles is bred by biofermentation technique, is being carried out Collect newborn program, Halophiles falls off Ectoin under good environment, then carries out multi-section and purify to obtain white powder high-purity Ectoin raw material finished product.In the second messenger of cell film layer reduction sunburn induction, (second messenger refers into the cell Ectoin The non-protein micromolecular of generation can induce a series of protein phosphorylations, finally cell be caused to be imitated by activated protein kinase Answer) it generates；Reducing the AP-2 because sunburn evokes in cellular plasm layer, (transcription factor-2 is that a kind of DNA of special serial number is combined Albumen can selectively be expressed with induction virus and cell enhancing original part interaction, stimulated gene) activity；In nucleus Reduce the life of anticusp inflammation factor after tanning severely (anticusp inflammation factor can lead to the cell factor such as interleukin 1 for generating inflammation) At.Ectoin plays good after-sun recovery effect to cell membrane, plasm and the multi-faceted influence of nucleus, can prevent Because of caused chain reaction of tanning severely, the induced mt-DNA mutation of prevention sunburn.And skin epidermis can also be protected to be located at Langerhans' cells (langerhans' cells Langerhans Cells is the important immunocyte of skin) between horn cell are exempted from Caused to injure and reach enhancing skin immune system by environmental stimuli.Can reduce 80-90% because ultraviolet light irradiation caused by The formation of sunburn cell.

Grease: it is good to moisten repairing effect.Wherein, emu is the large birds of Casuariiformes Dromiceidae, and the bodily form is former similar to ostrich Australia is produced, Australian ostrich is called.Its image is embedded on the national flag of Australia, is bird kind most ancient in the world One of.The physiological structure of emu is similar with camel, and the fat of whole body all concentrates in back fat capsule.It is extracted from adipose capsule Fat of Oromaius norvaehollandeae, collagen rich in, oleic acid, sub- fatty acid oil, vitamin E, vitamin A, OMEGA-3, OMEGA-6 etc. Natural component, being referred to as " mind oil " fat of Oromaius norvaehollandeae by Australia original inhabitant has the compatibility splendid with skin texture, especially contains A large amount of unsaturation olefin(e) acids, can enhance elasticity of skin, have extremely strong skin penetration, can obvious softening skin cuticula, calm down Wrinkle, removal dead skin, and the most desirable multiple nutritional components of human skin can be supplemented.2000~4000MW of small molecule is most easily by people Body skin and cell absorb；It can be good at having played infiltration, moisture-keeping function.Collagen in animal oils is extremely abundant. The loss of collagen is the basic reason of aging, and French LAVAYA science and technology laboratory is found, in human skin, collagen (collagen) it is primarily present in skin corium, as a kind of fiber head protein, collagen possesses fabulous support force, it Steel disk framework of the role just as skin histology；Unsaturated fatty acid: unsaturated fatty acid (is known as beauty acid), how unsaturated rouge Fat acid can be divided into omega-fatty acid (predominantly linolenic acid) and ω -6 fatty acid (predominantly linoleic acid) again.These are that human body must The fatty acid that need and human body itself cannot synthesize again.So also referred to as necessary fatty acid, according to world medical circle many decades to people The research of the essential fatty acid of body has shown that: when the essential fatty acid content omega-fatty acid of human body and the ratio of ω -6 fatty acid are When 1: 4, various diseases are difficult to invade human body.

Rose hip oil is rich in γ-linolenic acid, unsaturated fatty acid, palmitinic acid, citric acid, vitamin A, C, carotenoids Plain deep layer moisturizing provides nutrient, keeps skin soft, soft, wet, prevents ultraviolet light from damaging to skin, whitening flesh Skin；Increase vigor of skin tissue, keep skin high resilience, shrink coarse pore, dry cracked skin can be made to restore it naturally honorable； Tool strengthens the function of tissue effect and regeneration, and to cytothesis, maintenance and healing play the role of splendid, can effectively improve scar Trace, dark sore, whelk.To keeping moisture of skin effect distinguished, active function of organization, readily permeable skin corium are generated, moisturizing makes Skin is smooth.It can be such that skin pigment desalinates, and reappear the effect of homogeneous hue promotes skin smooth whitening, can also be pre- anti-sun Pigementation afterwards, sunburn are even all effective to psoriasis, eczema.

Grape seed oil is containing there are two types of important element, that is, linolenic acids (linoleic acid) and proanthocyanidin (0ligo Proanthocyanidin, abbreviation OPC), wherein linolenic acid is needed by human and for the fatty acid that human body cannot synthesize, With resistance free radical, elasticity that is anti-aging, strengthening the circulatory system and other effects；Procyanidine has protection blood vessel elasticity, prevents Platelet aggregation is hoarded on vascular wall and reduced to cholesterol.For skin, procyanidine can protect skin from ultraviolet light The destruction afflicted with great suffering torment, prevent collagenous fibres and elastomer, make skin keep it is due elasticity and tension, avoid skin sagging and Wrinkle generates.Antioxidant in grape pip also containing many strengths, such as young tiger gemic acid, cinnamic acid and vanillic acid are various natural Organic acid, these are all oxidation resistant elements.Grape seed oil penetration is strong, when can be used as facial massage and treatment, especially carefully Tender and sensitive skin, oiliness, dark sore, acne-prone skin.Containing abundant vitaminF, minerals, protein, the moisturizing of skin can be enhanced Effect, while can moisten, soft skin, the salubrious non-greasy of quality is easily absorbed by skin.Grape seed oil can also remove histamine, Histamine is to be attacked due to body basophil and mast cell by free radical, the cause for causing membranolysis to be released The scorching factor can cause a skin inflammation.

N- palmityl hydroxy-proline cetyl: there is stronger skin barrier function.N- palmityl hydroxy-proline whale This substance of wax ester is exactly the ceramide synthesized.Ceramide is naturally present in corneocyte interstitial, raw in cuticula It plays a crucial role in reason function, keeps skin smooth careful, prevent skin from drying because of water loss；Ceramide also assists in simultaneously The various physiological processes such as cell differentiation.But natural ceramide difficulty is extracted, price；And natural ceramide fusing point compares Height, it is bad to add in formula, because being easy crystallization.The ceramide of this synthesis of N- palmityl hydroxy-proline cetyl, energy The shortcomings that overcoming natural ceramide, structure are similar with natural ceramide.Efficacy test shows itself and natural ceramide It is same effective.This raw material can be used in anti-ageing product and remove for moisturizing and microgroove.Additive amount energy generally below 1% The effect played.The experimental data of one certain raw material quotient shows: using the N- palmityl hydroxy-proline spermaceti for containing 0.3% The anti-aging cream (noticing that this ingredient is that plan is used in anti-aging product) of ester is anti-ageing with the control group without this ingredient Cream is opposite, and the variation of skin moisture content is tested by Corrometer CM825 (moisture of skin tester), is made for a long time With rear, discovery improves 5.2% without the skin moisture content of N- palmityl hydroxy-proline cetyl, and uses and contain 0.3% The anti-ageing cream of N- palmityl hydroxy-proline cetyl, skin moisture content improve 21.4%.Show skin moisture-keeping energy The recovery of power.Bisabolol and N- palmityl hydroxy-proline cetyl have good synergistic effect, produce than individually adding Add the better skin barrier function maintenance effect of N- palmityl hydroxy-proline cetyl.Have not to the barrier function of maintenance skin The problems such as wrong effect improves and has dry skin to cuticle thickness and elasticity is increased, coarse has the effect of positive.

Fermentative brown rice filtrate and trehalose: the natural origin object of one group of high moisturizing.

Brown rice is a kind of Wholegrain rice with complete vitality, dietary fiber rich in, functional active components And minerals, cell viability and immune function of human body can be improved.Selected saccharomycete is as fermenting microbe, and brown rice is as main substrate It ferments.Nutriment after fermentation in brown rice is fully discharged, converted and is enriched with.Containing rich in fermentative brown rice filtrate Rich polypeptide, amino acid, antiactive oxygen phytic acid, ferulic acid, lactic acid, plant amide and sterol isoreactivity ingredient.These activity at Divide energy deep layer to nourish skin, inject vigour into for skin cell, effectively promote the injury repair of skin cell, resists aging, and And it is obscure to improve skin, keeps skin water profit beautiful.

Trehalose is a kind of natural carbohydrate, is a kind of non-reduced by stablizing of obtaining from cornstarch of biofermentation technique Property disaccharide, is highly soluble in water, trehalose can help organism to fight various harsh environment to keep the bioactivity of organism； By two glucose molecules with α, α -1,1- glucosides key connection forms trehalose, and chemical name is α-D- glucopyranosyl-α - D- glucopyranoside, has 2 crystallizations water, molecular formula C12H220112H20 under normal circumstances, and relative molecular mass is 378.33, the hydroxyl classification (having two kinds of α and β) based on first carbon on glucose molecule, trehalose have (α, α), (β, β), (α, β) 3 kinds of optical isomers, but (α, α) configuration trehalose can only be separated in organism.Since trehalose has 2 The glycosidic bond of hexamethylene sugar, therefore energy is lower, molecular structure is highly stable, can hardly also be decomposed by general enzyme, can only be by Trehalase with specificity is hydrolyzed.One layer of special protective film can be formed in cell surface in dry conditions, Aquation can also be played the role of in dehydration instead of moisture in cell with Bound Water Moleculess, to protect skin thin Born of the same parents will not be damaged.Trehalose can effectively prevent fibroblast in the dry state and be destroyed, and be with dose proportional, Exogenous trehalose is same as endogenous trehalose to have good non-specific defencive function to life entity and large biological molecule, And this protective effect seems all general to all biomolecule.Trehalose is highly safe, good physics and chemistry Stability and biological stability, excellent moisturizing, cytoprotection prevent grease from decomposing and reducing body odor, anti-radiation (removing α, β OH free radical caused by ray makes cell DNA be not susceptible to be mutated), prevent albuminous degeneration (for it is some can not room temperature with Keeping the activity of the biochemical substances such as active bEGF (epidermal growth factor), SOD (superoxide dismutase) for a long time has well Holding effect), Cutaneous permeation, reduce irritation and other effects.

Above six kinds are chosen the natural products functional component come, and are set about from the various injury symptoms of skin red capillary, are adopted Take the reparation of multipath from outside to inside.

Further, above-mentioned grease further includes shea butter, and the additional amount of the shea butter is skin composition The 3.0% of total weight.

The preferred technical solution of the present invention other one are as follows:

It is a kind of can Red blood streak dispelling skin composition, which is characterized in that including following components, and the additional amount of each component is equal In terms of skin composition total weight percent: fermentative brown rice filtrate 1.0-15.0%, avenabeta glucosan 0.2-2.0%, according to gram Mostly because of 0.1-3.0%, butanediol 4.0%, Natrulon H-10 3.0%, trehalose 0.5-3.0%, hydroxy-ethyl acrylate/acryloyl Dimethyltaurine sodium copolymer 1 .0%, hydrolysis Sodium Hyaluronate 0.1%, N- palmityl hydroxy-proline cetyl 0.05- 1.0%, dog rose fruit oil 0.5-5.0%, fat of Oromaius norvaehollandeae 0.5-5.0%, shea butter 3.0%, grape seed oil 0.5-5.0%, Rose hip oil 0.5-3.0%, tocopherol acetate 0.2%, bisabolol 0.1%, cetostearyl alcohol 1.5%, cetostearyl alcohol The smooth olive oleate 1.5% of olive oleate 1.5%, sorb, dimethyl silicone polymer 1.0%, dimethiconol 0.8%, double-PEG/PPG-16/16 PEG/PPG-16/16 dimethyl silicone polymers 0.08%, chamomile essential oil 0.2%, pungent Acid/Triglyceride DDD 0.12%, decoyl hydroximic acid 0.1%, glycerol caprylate 0.2%, propylene glycol 0.5%, 1,2- pentanediol 0.5%, vitamin P4 0.1-1%, Gotu Kola P.E 0.05-0.5%, glycyrrhiza glabra root extract 0.05-0.5%, mountainous region Mugwort extract 0.05-0.5%, narrow leaf blueberry berry extract 0.05-0.5%, ginkgo biloba p.e 0.05-0.5%, to hydroxyl Acetophenone 0.2%, disodium ethylene diamine tetraacetate 0.02%, surplus are water.

Another goal of the invention of the present invention be to provide it is a kind of can Red blood streak dispelling skin composition preparation method, according to each Weight percent of the component in skin composition, is prepared by following steps:

According to weight percent of each component in skin composition, prepared by following steps:

S1: by dog rose fruit oil, fat of Oromaius norvaehollandeae, shea butter, grape seed oil, rose hip oil, tocopherol acetate, red do not have Oily phase pot is added in the smooth olive oleate of medicine alcohol, cetostearyl alcohol, cetostearyl alcohol olive oleate, sorb, and stirring is warming up to 75- 80℃；

S2: by Ectoin, butanediol, Natrulon H-10, trehalose, hydroxy-ethyl acrylate/acryloyldimethyl taurine Sodium copolymer, hydrolysis Sodium Hyaluronate, N- palmityl hydroxy-proline cetyl, vitamin P4, disodium ethylene diamine tetraacetate, water It is sequentially added into emulsion pot, stirring is warming up to 80-85 DEG C, and stirring homogeneous 3 minutes is to being uniformly dispersed:

S3: vacuum is pumped into emulsion pot: oily phase pot Material being pumped into emulsion pot, extremely emulsifies heat preservation completely within stirring homogeneous 5 minutes 5 minutes；

S4: emulsion pot stirring is cooled to 55-60 DEG C, by the dimethyl silicone polymer being pre-mixed, polydimethylsiloxanes Alkanol, double-PEG/PPG-16/16 PEG/PPG-16/16 dimethyl silicone polymers, chamomile essential oil %, caprylic/capric glycerol Emulsion pot, then decoyl hydroximic acid, glycerol caprylate, propylene glycol, 1, the 2- pentanediol, para hydroxybenzene that will melt in advance is added in three esters Ethyl ketone keeps the temperature 5 minutes to emulsifying completely in stirring homogeneous 3 minutes；

S5: emulsion pot continues stirring and is cooled to 45 DEG C hereinafter, fermentative brown rice filtrate, avenabeta glucosan, centella are mentioned Take object, glycyrrhiza glabra root extract, mountainous region mugwort extract, narrow leaf blueberry berry extract, ginkgo biloba p.e that emulsion pot is added, Stirring 10 minutes to being uniformly dispersed；

S6:38 DEG C or so sample detection items physical and chemical index, it is qualified after filtering and discharging obtain target product.

A kind of above-mentioned preparation method be prepared can the skin composition of Red blood streak dispelling preparing answering in skin care item It using form is lotion, frost, cream, any form in aqua with, skin care item.

The invention has the beneficial effects that: the moisturizing that skin composition of the present invention and preparation method thereof is prepared Frost can effectively repair skin because cutin is damaged telangiectasis, silting, the impaired red capillary formed, also have property temperature With the superperformances such as skin sense silk is sliding, pro-skin easily absorbs.

Specific embodiment

Below in conjunction with detailed description of the invention by specific embodiments.

Percentage involved in following embodiment is the total weight according to composition.

Embodiment 1: skin cream is prepared.

The raw material of skin cream forms are as follows: fermentative brown rice filtrate 3.0%, avenabeta glucosan 0.2%, Ectoin 0.5%, Butanediol 4.0%, Natrulon H-10 3.0%, trehalose 1.0%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymerization Object 1.0%, hydrolysis Sodium Hyaluronate 0.1%, N- palmityl hydroxy-proline cetyl 0.05%, dog rose fruit oil 2%, Er Emu oil 1.0%, shea butter 3.0%, grape seed oil 2.0%, rose hip oil 2.0%, tocopherol acetate 0.2%, opopanax Alcohol 0.1%, cetostearyl alcohol 1.5%, cetostearyl alcohol olive oleate 1.5%, the smooth olive oleate 1.5% of sorb, poly- two Methylsiloxane 1.0%, dimethiconol 0.8%, double-PEG/PPG-16/16 PEG/PPG-16/16 poly dimethyls Siloxanes 0.08%, chamomile essential oil 0.2%, caprylic/capric triglyceride 0.12%, decoyl hydroximic acid 0.1%, glycerol octanoic acid Ester 0.2%, propylene glycol 0.5%, 1,2- pentanediol 0.5%, vitamin P4 0.2%, Gotu Kola P.E 0.05%, light fruit are sweet Grass roots extract 0.05%, mountainous region mugwort extract 0.05%, narrow leaf blueberry berry extract 0.05%, ginkgo biloba p.e 0.05%, parahydroxyacet-ophenone 0.2%, disodium ethylene diamine tetraacetate 0.02%, surplus are water.

Embodiment 2:

The raw material of skin cream forms are as follows: fermentative brown rice filtrate 5.0%, avenabeta glucosan 0.5%, Ectoin 1.0%, Butanediol 4.0%, Natrulon H-10 3.0%, trehalose 1.0%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymerization Object 1.0%, hydrolysis Sodium Hyaluronate 0.1%, N- palmityl hydroxy-proline cetyl 0.2%, dog rose fruit oil 2.0%, Fat of Oromaius norvaehollandeae 2.0%, grape seed oil 3.0%, rose hip oil 2.0%, tocopherol acetate 0.2%, red does not have shea butter 3.0% Medicine alcohol 0.1%, cetostearyl alcohol olive oleate 1.5%, the smooth olive oleate 1.5% of sorb, gathers cetostearyl alcohol 1.5% Dimethyl siloxane 1.0%, dimethiconol 0.8%, double poly- diformazans of-PEG/PPG-16/16 PEG/PPG-16/16 Radical siloxane 0.08%, chamomile essential oil 0.2%, caprylic/capric triglyceride 0.12%, decoyl hydroximic acid 0.1%, caprylic Acid esters 0.2%, propylene glycol 0.5%, 1,2- pentanediol 0.5%, vitamin P4 0.3%, Gotu Kola P.E 0.1%, light fruit are sweet Grass roots extract 0.1%, mountainous region mugwort extract 0.1%, narrow leaf blueberry berry extract 0.1%, ginkgo biloba p.e 0.1%, Parahydroxyacet-ophenone 0.2%, disodium ethylene diamine tetraacetate 0.02%, surplus are water.

Embodiment 3:

The raw material of skin cream forms are as follows: fermentative brown rice filtrate 8.0%, avenabeta glucosan 1.0%, Ectoin 2.0%, Butanediol 4.0%, Natrulon H-10 3.0%, trehalose 2.0%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymerization Object 1.0%, hydrolysis Sodium Hyaluronate 0.1%, N- palmityl hydroxy-proline cetyl 0.05-1.0%, dog rose fruit oil 3.0%, fat of Oromaius norvaehollandeae 3.0%, shea butter 3.0%, grape seed oil 2.0%, rose hip oil 3.0%, tocopherol acetate 0.2%, bisabolol 0.1%, cetostearyl alcohol 1.5%, cetostearyl alcohol olive oleate 1.5%, the smooth olive oleic acid of sorb Ester 1.5%, dimethyl silicone polymer 1.0%, dimethiconol 0.8%, double-PEG/PPG-16/16 PEG/PPG- 16/16 dimethyl silicone polymer 0.08%, chamomile essential oil 0.2%, caprylic/capric triglyceride 0.12%, decoyl hydroximic acid 0.1%, glycerol caprylate 0.2%, propylene glycol 0.5%, 1,2- pentanediol 0.5%, vitamin P4 0.3%, Gotu Kola P.E 0.15%, glycyrrhiza glabra root extract 0.15%, mountainous region mugwort extract 0.15%, narrow leaf blueberry berry extract 0.15%, silver Apricot leaf extract 0.15%, parahydroxyacet-ophenone 0.2%, disodium ethylene diamine tetraacetate 0.02%, surplus are water.

The preparation method of embodiment 1-3 is identical, are as follows: first will be by dog rose fruit oil, fat of Oromaius norvaehollandeae, shea butter, Portugal Grape seed oil, rose hip oil, tocopherol acetate, bisabolol, cetostearyl alcohol, cetostearyl alcohol olive oleate, sorb are smooth Oily phase pot is added in olive oleate, and stirring is warming up to 75-80 DEG C；Again by Ectoin, butanediol, Natrulon H-10, trehalose, Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, hydrolysis Sodium Hyaluronate, N- palmityl hydroxy-proline spermaceti Ester, vitamin P4, disodium ethylene diamine tetraacetate, water are sequentially added into emulsion pot, and stirring is warming up to 80-85 DEG C, and stirring homogeneous 3 divides Clock is to being uniformly dispersed；Then vacuum is pumped into emulsion pot: oily phase pot Material being pumped into emulsion pot, stirring homogeneous 5 minutes is to having emulsified Entirely, 5 minutes are kept the temperature；Emulsion pot stirring again is cooled to 55-60 DEG C, by the dimethyl silicone polymer being pre-mixed, poly- diformazan Radical siloxane alcohol, double-PEG/PPG-16/16 PEG/PPG-16/16 dimethyl silicone polymers, chamomile essential oil %, the octanoic acid/last of the ten Heavenly stems Acid glycerol three ester is added emulsion pot, then by the decoyl hydroximic acid melted in advance, glycerol caprylate, propylene glycol, 1,2- pentanediol, right Hydroxy acetophenone keeps the temperature 5 minutes to emulsifying completely in stirring homogeneous 3 minutes；Again by emulsion pot continue stirring be cooled to 45 DEG C with Under, by fermentative brown rice filtrate, avenabeta glucosan, Gotu Kola P.E, glycyrrhiza glabra root extract, mountainous region mugwort extract, Emulsion pot is added in narrow leaf blueberry berry extract, ginkgo biloba p.e, and stirring 10 minutes to being uniformly dispersed；Finally taken at 38 DEG C or so Sample detects every physical and chemical index, and filtering and discharging obtains target product after qualification.

It is preferred embodiment with embodiment 2, and carries out both effectiveness test using the preparation-obtained skin cream of embodiment 2.

The specific testing process of both effectiveness test are as follows:

1, object and method:

1.1 objects: random, open, Self-controlled study is taken.It chooses Guangzhou red capillary patient total 50 and (works as skin Impaired 30%, it is in dotted red capillary I grade 21；Skin damage 50% is linear red capillary II grade 16；Skin by Damage 70% is in netted red capillary III level 9；Skin damage 90% is flaky red capillary IV grade 4), wherein male Property patient 12, female patient 38,18 years old or more each age group.All patient's voluntary participation clinical observations sign and know together Meaning book, and promise to undertake and use the skin cream as required.

Inclusion criteria: patient has long-term or short-term skin red capillary illness before 1. observing, and does not use during observation Living cells therapy, physiotherapy, chemotherapy and other Red blood streak dispelling products similar with the present invention；2. during observation not Excessive drinking, does not eat excessive maror.

1.2 research methods:

1.2.1 application method:

Patient daily sooner or later by Irrigation it is clean after skin cream is uniformly applied to affected part, continue 56d or more, cannot between It is disconnected.

1.2.2 observation item and scoring:

Skin lesion improves situation: patient using the 7th after preceding and use, 14,28d respectively observe once, record use front and back skin Damage improves situation.The state presented to skin red capillary: dotted, linear, netted, sheet scores according to 4 grades of point systems, together When observe and record adverse reaction.

Red capillary improves situation: patient using the 7th after preceding and use, 14,28,56d respectively observe once, before record use Red capillary improves situation afterwards.

1.2.3 curative effect judging standard:

For red blood trace on face improve situation, we are defined as follows: skin red capillary present state grade reduce and It is effective for fully recovering, and is statisticallyd analyze after use without significant change to be invalid

Table 1 uses preceding each patient profiles

2 7d clinical effectiveness of table compares (example)

3 14d clinical effectiveness of table compares (example)

4 28d clinical effectiveness of table compares (example)

5 56d clinical effectiveness of table compares (example)

Result of study shows that Red blood streak dispelling skin cream has apparent therapeutic effect to different degrees of red blood trace on face, It is visible certain effect after the 7th day, the state that red capillary is presented and the rate that is almost recovered mention with the extension of use time Height, using the 28th day rate that is almost recovered up to 36% or more；The 56th day rate that is almost recovered is up to 76% or more；It does not fully recover part People is because starting red capillary degree is more serious, but in 56 days, red blood trace on face situation also has very good mitigation

2, result:

Skin lesion improves situation assessment patient using after skin cream 7d of the present invention, and skin specific retention is significantly improved, red after 56d The trace of blood is almost recovered rate up to 76% or more；There is significant difference (specific number using 14d, 28d, 56d and 7d indices According to seeing each table).

Clinical curative effect analysis

After skin cream 7d of the present invention, existing 8% patient is almost recovered (4/50), the acne base of 14d, 28d, 56d This cure rate is respectively 14% (7/50), 36% (18/50) and 76% (38/50), and clinical effectiveness is superior to 7d, and 28d is excellent It is better than 28d in 14d, 56d.

Adverse reaction

During skin cream of the present invention, do not occur adverse reaction, patient is reflected that the skin sense of this skin cream is good, do not pierced Swash property and uncomfortable feeling, all patients complete entire experiment.

The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should Understand, the above embodiments do not limit the invention in any form, all obtained by the way of equivalent substitution or equivalent transformation Technical solution is fallen within the scope of protection of the present invention.

Claims (5)

1. one kind can Red blood streak dispelling skin composition, which is characterized in that in the acceptable matrix of skin composition, at least wrap Following active component is included, and the additional amount of the active component is in terms of skin composition total weight percent:

(1) composite plant Red blood streak dispelling preparation: by Gotu Kola P.E 0.05-0.5%, glycyrrhiza glabra root extract 0.05- 0.5%, mountainous region mugwort extract 0.05-0.5%, narrow leaf blueberry berry extract 0.05-0.5%, ginkgo biloba p.e 0.05- 0.5%, dog rose fruit oil 0.5-5.0% compounding is constituted；

(2) vitamin P4 0.1-1%；

(3) skin repair component: avenabeta glucosan 0.2-2.0% and Ectoin 0.1-3.0%；

(4) grease: fat of Oromaius norvaehollandeae 0.5-5.0%, rose hip oil 0.5-3.0% and grape seed oil 0.5-5.0%；

(5) N- palmityl hydroxy-proline cetyl 0.05-1.0%；

(6) moisturizing component: fermentative brown rice filtrate 1.0-15.0% and trehalose 0.5-3.0%.

2. one kind according to claim 1 can Red blood streak dispelling skin composition, which is characterized in that the grease also wraps Shea butter is included, and the additional amount of the shea butter is the 3.0% of skin composition total weight.

3. one kind can Red blood streak dispelling skin composition, which is characterized in that including following components, and the additional amount of each component with Skin composition total weight percent meter: fermentative brown rice filtrate 1.0-15.0%, avenabeta glucosan 0.2-2.0%, Ectoin 0.1-3.0%, butanediol 4.0%, Natrulon H-10 3.0%, trehalose 0.5-3.0%, hydroxy-ethyl acrylate/acryloyldimethyl ox Sodium sulfonate copolymers 1.0%, hydrolysis Sodium Hyaluronate 0.1%, N- palmityl hydroxy-proline cetyl 0.05-1.0%, dog tooth rose Common vetch fruit oil 0.5-5.0%, fat of Oromaius norvaehollandeae 0.5-5.0%, shea butter 3.0%, grape seed oil 0.5-5.0%, rose hip oil 0.5-3.0%, Tocopherol acetate 0.2%, bisabolol 0.1%, cetostearyl alcohol 1.5%, cetostearyl alcohol olive oleate 1.5%, sorb are smooth Olive oleate 1.5%, dimethyl silicone polymer 1.0%, dimethiconol 0.8%, double-PEG/PPG-16/16 PEG/ PPG-16/16 dimethyl silicone polymer 0.08%, chamomile essential oil 0.2%, caprylic/capric triglyceride 0.12%, decoyl hydroxyl oxime Sour 0.1%, glycerol caprylate 0.2%, propylene glycol 0.5%, 1,2- pentanediol 0.5%, vitamin P4 0.1-1%, Gotu Kola P.E 0.05-0.5%, glycyrrhiza glabra root extract 0.05-0.5%, mountainous region mugwort extract 0.05-0.5%, narrow leaf blueberry berry extract 0.05-0.5%, ginkgo biloba p.e 0.05-0.5%, parahydroxyacet-ophenone 0.2%, disodium ethylene diamine tetraacetate 0.02%, surplus For water.

4. it is a kind of it is as claimed in claim 3 can Red blood streak dispelling skin composition preparation method, which is characterized in that according to each group Divide the weight percent in skin composition, prepared by following steps:

S1: by dog rose fruit oil, fat of Oromaius norvaehollandeae, shea butter, grape seed oil, rose hip oil, tocopherol acetate, opopanax Oily phase pot is added in the smooth olive oleate of alcohol, cetostearyl alcohol, cetostearyl alcohol olive oleate, sorb, and stirring is warming up to 75-80 ℃；

S2: Ectoin, butanediol, Natrulon H-10, trehalose, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate is total Polymers, hydrolysis Sodium Hyaluronate, N- palmityl hydroxy-proline cetyl, vitamin P4, disodium ethylene diamine tetraacetate, water are by suitable Emulsion pot is added in sequence, and stirring is warming up to 80-85 DEG C, and stirring homogeneous 3 minutes is to being uniformly dispersed；

S3: vacuum is pumped into emulsion pot: oily phase pot Material being pumped into emulsion pot, keeps the temperature 5 points to emulsifying completely within stirring homogeneous 5 minutes Clock；

S4: emulsion pot stirring be cooled to 55-60 DEG C, by the dimethyl silicone polymer being pre-mixed, dimethiconol, Double-PEG/PPG-16/16 PEG/PPG-16/16 dimethyl silicone polymers, chamomile essential oil %, caprylic/capric triglyceride add Enter emulsion pot, then decoyl hydroximic acid, glycerol caprylate, propylene glycol, 1, the 2- pentanediol, parahydroxyacet-ophenone that will melt in advance, Homogeneous 3 minutes are stirred to emulsifying completely, keeps the temperature 5 minutes；

S5: emulsion pot continue stirring be cooled to 45 DEG C hereinafter, by fermentative brown rice filtrate, avenabeta glucosan, Gotu Kola P.E, Emulsion pot, stirring is added in glycyrrhiza glabra root extract, mountainous region mugwort extract, narrow leaf blueberry berry extract, ginkgo biloba p.e 10 minutes to being uniformly dispersed；

S6:38 DEG C or so sample detection items physical and chemical index, it is qualified after filtering and discharging obtain target product.

5. a kind of preparation method as claimed in claim 4 be prepared can the skin composition of Red blood streak dispelling preparing skin care item In application, the skin care item are lotion, frost, cream, any form in aqua using form.