KR20220058240A - Cream Composition for moisturizing and improvement of skin itching comprising the extract of natural products - Google Patents

Abstract

The present invention relates to a cream composition for moisturizing skin and alleviating skin itching which comprises: a Houttuynia cordata extract; a Glycyrrhiza glabra root extract; a Centella asiatica extract; a Portulaca oleracea extract; a Scutellariae radix extract; a cabbage extract; and a kelp extract as active ingredients. The cream composition according to the present invention has itching alleviation and moisturizing effects and thus helps to alleviate sensitive skin. In addition, the cream composition has hypoallergenic properties to minimize allergic reactions and to relieve or alleviate skin troubles such as itching, inflammation, erythema, and skin damage. In particular, the cream composition can be usefully used to improve skin itching.

Description

Cream composition for moisturizing and improvement of skin itching comprising the extract of natural products

The present invention relates to a cream composition for moisturizing the skin or improving skin itching, comprising, as active ingredients, a yakmomil extract, a licorice root extract, a centella asiatica extract, a purslane extract, a golden extract, a cabbage extract and a kelp extract.

As a conventional natural extract technology related to itch, Korean Patent Laid-Open No. 2007-0095588 describes a special oriental herbal composition for atopic skin disease treatment and a method for manufacturing the same, including eoseongcho, angelica, wormwood, chrysanthemum sagebrush, chrysanthemum, Compositions of pine needles, mint, mung bean, apricot seed, rosin, sagebrush, ginger, ginseng, cuttlefish, green tea, marigold, bellflower, gold and silver bean are described, and Korean Patent Publication No. 2006-0074038 for the prevention of atopic dermatitis As a composition having an effect, a mixed extract of Geumgeumhwa, Angelica, Bupyeongcho, hyssop, marigold, aloe, and gold is described. In addition, in Korea Patent Publication No. 2006-0092373, the prevention and improvement of atopic dermatitis in children of a composition containing pollen, tonic, cordyceps, and cauliflower as main components, and further comprising gold ginseng, ginseng, ginseng, or pogongyeong as optional components Korean Patent Laid-Open No. 2007-0110589 describes the application of a composition for inhibiting human cell binding of acne-prone bacilli containing acidic polysaccharides isolated from mugwort and Staphylococcus aureus atopy, Korea Patent Laid-Open No. 2001-0003116 describes a functional food for the treatment of atopic dermatitis, characterized in that it contains a water extract and salt of green leaf and purpurea leaf.

The herbal medicines have functions, such as dermatitis-related physiological activity, and have been frequently used in cosmetics for this purpose, but the effect appeared within a short time and was insignificant. In particular, as a characteristic of pruritus, dry skin appears before itching symptoms, and this dryness causes itching, which induces scratching again, and even secondary infection. is being tried Dryness and itchiness are known to appear through damage to the skin cell membrane, and for this reason, it is known that it can help alleviate the symptoms of dryness and itching by protecting the cell membrane with lipids and fatty acids, such as ceramides, which are components of the cell membrane. .

The present inventors have confirmed that the cream composition comprising, as an active ingredient, an extract of yam buckwheat, licorice root extract, centella asiatica extract, purslane extract, golden extract, cabbage extract and kelp extract continuously maintains and improves skin moisture even in a long-term test, and further The present invention has been completed by confirming that it is possible to improve the itching caused by dry skin.

It is an object of the present invention to provide a cream composition for moisturizing or improving skin itchiness, comprising, as an active ingredient, a yakmomil extract, a licorice root extract, a Centella asiatica extract, a purslane extract, a golden extract, a cabbage extract and a kelp extract.

This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be considered that the scope of the present invention is limited by the specific descriptions described below.

One aspect of the present invention for achieving the above object is a cream composition for moisturizing or improving skin itching, comprising, as an active ingredient, an herbal extract, licorice root extract, Centella asiatica extract, purslane extract, golden extract, cabbage extract and kelp extract. am.

It is well known that certain skin types are more sensitive than others, and such skin is commonly referred to as sensitive skin. Sensitive skin is more prone to contact stimuli or allergic reactions than the average group. Although the cause of sensitive skin is not clearly known, it is generally known that it is influenced by external factors such as cosmetics, psychological and physical stress, and other environmental substances such as air pollution. Symptoms that often appear in people with sensitive skin include visible reactions such as erythema, dry skin, stinging, itching (itchiness) or inflammation, and the number of people with sensitive skin is increasing.

Itching (pruritus) is a symptom that causes the urge to scratch regardless of one's will, and it is common in skin diseases. When the severity or frequency of occurrence is high, the quality of life of patients is adversely affected, so prevention, treatment or symptom improvement of pruritus is a very important issue. For example, many types of skin diseases such as atopic dermatitis, food allergy, and parasitic infection cause erythema and mild itching. there is. Inflammation is a kind of reaction that occurs in the body when a living tissue is damaged. Fever, seizure, burning, and pain occur, which are called the four major signs of inflammation. In the inflammatory reaction, mast cells are activated, chemical mediators such as histamine, heparin, and serotonin stored in the granules are separated, inflammatory cytokines including leukotriene and prostaglandins are secreted, and inflammatory cells such as neutrophils and macrophages increase in the lesion site. Induces inflammatory and allergic reactions. Accordingly, blood vessels are dilated, permeability is increased, tissue edema, increased mucus secretion, and immune cell infiltration occurs.

Itching can appear in many diseases, and the causes are very diverse. In particular, there is a high tendency for the itch to continue to worsen and recur due to the act of 'scratching'. Although the causes of itching are various, such as dry skin, constitutional characteristics, infections caused by bacteria, viruses, fungi, emotional factors, and environmental factors, the mechanism of repeated itchiness begins with 'scratching' and is caused by scratching. As the inflammation occurs repeatedly, it appears in the form of more severe itching. Atopic dermatitis is the most representative itch, and in the case of atopic dermatitis, an abnormal immune response and a decrease in the skin's defense function are known to be the causes, but it is not clear.

If it progresses from pruritus to inflammation, it can be classified into atopic dermatitis and contact dermatitis, which are accompanied by skin redness, skin edema, blistering ulcers, and severe itching. If the treatment for the atopic dermatitis is not carried out, the skin is continuously exposed to substances that promote skin reaction, and the contact dermatitis becomes chronic, and if the chronic contact dermatitis is repeated, the skin becomes thick, peels off, becomes dry, and the color changes. In severe cases, hair loss occurs.

This type of dermatitis accounts for 0.5 to 1% of the total population and 5 to 10% in children. In the past, it was known as a disease that occurred briefly in childhood, but a recent study found that 50% of patients disappear within two years, 25% persist into adolescence, and the remaining 25% persist into adulthood.

Accordingly, in recent years, there is an increasing demand for cosmetics or external skin composition that can be safely used by owners of sensitive or extremely sensitive skin, such as atopic skin, without irritation. Research is also actively underway.

The cosmetic composition for itchy skin, such as atopic skin and (extreme) sensitive skin, as described above, has an anti-sedative effect for suppressing or alleviating existing itch without causing itching and skin irritation, an anti-inflammatory effect, and a destroyed skin barrier It needs the effect of inhibiting bacteria that inhibits the growth of bacteria in the skin, moisturizing, maintaining and repairing the skin barrier, and protecting the skin.

The present invention relates to a cream composition that has a moisturizing effect and helps relieve itching by utilizing an active substance derived from nature. Naturally derived extracts used to make the composition were selected by focusing on natural products that are traditionally known to help soothe the skin and relieve inflammation in oriental medicine. , golden extract, cabbage extract, and kelp extract as an active ingredient, a very good moisturizing effect and skin itch improvement effect could be confirmed.

Yakmomil is a perennial herb belonging to the family Sambokaceae. It grows wild in Korea, China, Japan, and Vietnam. In the present invention, ready-made products prepared by extracting the yakmomil extract and yakmomil water by a conventional method were used. As a traditional medicinal plant, Yakmomil, which has shown efficacy in a wide range of fields, has been reported to have antioxidant, antibacterial, anti-allergic, and immune-enhancing effects.

Licorice is a perennial plant belonging to the legume family, distributed in China, Siberia, Mongolia, etc., and is one of the widely used medicinal plants worldwide. Traditionally, licorice is known as an effective herb for cough relief, sputum removal, pain relief, and stomach strengthening, and through recent studies, several pharmacological effects such as anti-tumor, anti-microbial, anti-viral, anti-inflammatory, antioxidant, immune-modulating, and hepatoprotective effects have been found. It is known to have phosphorus activity. In cosmetics, it has been reported to be effective in suppressing skin discoloration and pigmentation, alleviating skin irritation and soothing.

Centella asiatica, called Centilla asiatica by its scientific name, is a plant that grows in humid places and is distributed in Asia including Korea, Japan, China, India, and the eastern United States. Byeongpum extract is a drug that improves symptoms related to venous circulation disorders when used as an oral drug, and is used as an auxiliary treatment for wounds or skin ulcers when used externally. It is also known to work by strengthening the connective tissue of blood vessels and increasing collagen formation. In the past, it is known that it mainly has wound healing and antioxidant effects in China. Centella asiatica was also used in ancient China, and it is reported that it was mainly used for wound healing and antioxidant effects. It is known to be effective in skin regeneration, antibacterial, anti-inflammatory, antioxidant, and skin tone improvement, so it is in the spotlight as a cosmetic ingredient.

Purslane is an annual weed of the purslane family, and is also called five elements such as ohaengcho, jangmyungchae, and machichae. According to 'Donguibogam', purslane has a cold nature, and is known to play a role in reducing heat and relieving eohyeol.

Gold is the root of Scutellariae Radix, either as it is or with the bark removed. It is distributed in Korea, China, Mongolia and eastern Siberia, and is used as an antipyretic, diuretic, diuretic, diarrhoea, and anti-inflammatory agent in oriental medicine.

Cabbage (Brassica oleracea var. capitata) belongs to the dicotyledonous perennials or biennials of the mustard family, and has been shown to have physiological activities such as antioxidant, antibacterial, or anticancer, and its efficacy and effect have been verified through various clinical trials.

Kelp (Laminaria japonica) belongs to the brown algae kelp family, and in the oriental medicine world, dried fronds are called bales and used as herbal medicines. As it contains a large amount of minerals such as iodine and potassium, it has the effect of promoting metabolism.

Each of the extracts may be extracted through a known extraction method. The above-mentioned various extracts can be prepared using conventional extraction solvents under conventional temperature and pressure conditions according to conventional extraction methods known in the art, and the type and content of the extraction solvent are also selected under arbitrary conditions. can be The extracts may be extracted using one or more extraction solvents selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, etc., for example, water and / or 70% ethanol or water and/or 1,3-butylene glycol may be used, but not limited thereto. The extraction methods include hot-water extraction, heat extraction, reflux cooling extraction, ultrasonic extraction, supercritical extraction using carbon dioxide, low-temperature compression, extraction using an ultrafiltration membrane having a constant molecular weight cut-off value, extraction using various chromatography methods, etc. Conventional extraction methods known in the art may be used. The extract is one or more selected from the group consisting of water, C ₁ to C ₄ lower alcohol, n-hexane, ethyl acetate, acetone, butyl acetate, 1,3-butylene glycol, methylene chloride, and mixed solvents thereof. It may be extracted with a solvent.

The cream composition of the present invention may be prepared by a known cream preparation method while including the mixed extract as an active ingredient. The composition may be prepared by including some fragrance, and the fragrance used at this time for sensitive skin may be prepared using an allergy-free certified product.

The cream composition of the present invention has an excellent effect of improving and alleviating itching symptoms with a skin moisturizing effect. In a specific embodiment of the present invention, as a result of applying the cream composition to the patient's skin, it was confirmed that the skin moisture content was improved in the long term, and it was confirmed that the skin itchiness was also remarkably improved. Therefore, the cream composition of the present invention can be very usefully used for skin moisturizing and/or skin itch improvement.

The cream composition according to the present invention has an itch improvement and moisturizing effect, so it helps to improve sensitive skin, has hypoallergenicity, so it minimizes allergic reactions, and relieves skin troubles such as itchiness, inflammation, erythema, and skin damage. can be improved In particular, it can be usefully used to improve skin itchiness.

Hereinafter, the configuration and effects of the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and the scope of the present invention is not limited by these examples.

Preparation Example 1: Preparation of cream composition

The cream composition of the present invention was prepared by mixing Yakmomil extract, licorice root extract, Centella asiatica extract, purslane extract, golden extract, cabbage extract and kelp extract.

Experimental Example 1: Corneometer ^® Evaluation of skin moisture content improvement effect using

1. Criteria for selection of research subjects

1) Those who usually have itching due to dryness in the test site

2) A person who voluntarily writes and signs the consent form after fully explaining the matters that the principal investigator or the person authorized by the principal investigator should inform the subject of the study

3) A healthy person without acute or chronic physical disease including skin disease

4) Those who can follow-up during the test period

2. Criteria for Exclusion of Study Subjects

1) Pregnant or lactating women and women of childbearing potential

2) Those who have used external skin preparations containing steroids for more than 1 month for the treatment of skin diseases

3) Those who have not passed 6 months after participating in the same exam

4) Those with sensitive skin

5) Those who have skin abnormalities such as spots, acne, erythema, and capillary dilatation at the test site

6) Those who have used the same or similar efficacy cosmetics and medicines at the test site within 3 months before the start of the study

7) Those who have had surgery on the test site within 6 months before the start of the study

8) Others who are considered unsuitable for the test at the discretion of the principal investigator

3. Criteria for dropout of study subjects

1) In case of adverse events such as pruritus or erythema at the test site

2) In the event that the evaluation of the results is impaired due to excessive UV exposure to the test site or excessive drinking or smoking during the course of the test

3) When it is difficult for the research subject to follow up due to personal circumstances during the course of the test

4. Number of study subjects and their rationale

Based on the Ministry of Food and Drug Safety's 'Test Method Guidelines for Cosmetic Labeling and Advertising Demonstration (Mar. 2018)' and the Korean Dermatological Research Institute's own regulations, effective data of more than 20 people were secured.

5. Test method

Corneometer ^® CM 825 (Courage & Khazaka electronic GmbH, Germany) is a device that indirectly measures the moisture content by using the property that the capacitance of the skin increases in proportion to the moisture content. It has high reproducibility, is easy to handle, and has a short measurement time, so it is most often used to measure the moisture content of the skin. The measurement principle is based on the physical law using two complex metal plate capacitors that are electrically insulated by a medium that is an insulator. The unit of measurement is expressed as Arbiturary Unit (AU), which is a relative, arbitrary value of skin moisture content. After attaching the probe attached to the Corneometer ^® to the skin surface vertically, press lightly to measure the moisture content.

The subject of the study made a first visit before the test to hear about the test method, schedule, risks, and possible adverse reactions, etc. After washing their face, pat them lightly with a paper towel to remove moisture, ~60% RH). The measurement site was partitioned by the intersection point of the horizontal line on the alare and the mid-pupillary line so that measurements could be made at the same site for each evaluation. After each measurement was performed 5 times with a Corneometer ^® , the average value of the measurements was recorded as the measurement value. After educating the study subjects on precautions and sample usage, the cream composition of Preparation Example 1 as a sample was distributed, and compliance with the sample use was checked every day during the test period by telephone or the like. The study subjects used the cream composition of the present invention twice daily in the morning and evening for 4 weeks.

The second visit was made 2 weeks after the test and the third visit was made 4 weeks after the test, and device evaluation was performed in the same site as on the first visit.

6. Evaluation method

The moisture content improvement rate was calculated as follows from the skin moisture content measured using Corneometer ^® before the test, 2 weeks after the test, and 4 weeks after the test.

7. Test results

As a result of using the cream composition of the present invention to study subjects during the test period of 4 weeks, it was confirmed that the Corneometer ^® measurement value (AU) indicating the skin moisture content was significantly increased compared to before the test. Therefore, it can be seen that the cream composition of the present invention has an excellent effect of increasing the skin moisture content to a statistically significant level even when applied to the skin for a long period of time.

Experimental Example 2: Evaluation of pruritus improvement effect

In Experimental Example 1, pruritus evaluation was performed on study subjects who visited before the test, 2 weeks after the test, and 4 weeks after the test. The evaluation criteria were performed with the same questions as in Table 1 below, and scores were given on a scale of 0 to 4 depending on the degree of pruritus.

score Evaluation standard 0 no itching at all One slight itchiness 2 Severe itching 3 there is a lot of itching 4 very severe itching

As a result of the evaluation, it was confirmed that the evaluation value of pruritus due to dry skin of the study subject was significantly reduced compared to before the test, and the symptoms of pruritus of the subject were improved. Therefore, it can be seen that the cream composition of the present invention has an excellent effect of improving skin itching to a statistically significant level even when applied to the skin for a long period of time.

Experimental Example 3: Safety evaluation by a dermatologist

The occurrence of side effects (erythema, edema, scale, itching, stinging, burning, stiffness, tingling and other abnormalities) by using the cream composition of the present invention during the test period was evaluated, but no adverse skin reactions were observed from all study subjects. .

In conclusion, it was confirmed that the skin moisture content was increased to a statistically significant level compared to before the test at the test site using the cream composition of the present invention for 4 weeks, and skin itchiness was improved. Therefore, the cream composition of the present invention can be very usefully used for skin moisturizing and/or skin itch improvement.

Claims (2)

A cream composition for moisturizing or improving skin itching, comprising, as an active ingredient, a yakmomil extract, a licorice root extract, a centella asiatica extract, a purslane extract, a golden extract, a cabbage extract and a kelp extract.
According to claim 1, wherein each of the extracts are water, C ₁ to C ₄ lower alcohol, n-hexane, ethyl acetate, acetone, butyl acetate, 1,3-butylene glycol, methylene chloride, and mixtures thereof. A cream composition for skin moisturizing or skin itch improvement, characterized in that it is extracted with one or more solvents selected from the group consisting of.