CN108114084A - It is a kind of to be used to improve Chinese medicine composition of eyesight and preparation method thereof - Google Patents
It is a kind of to be used to improve Chinese medicine composition of eyesight and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The present invention relates to a kind of for improving Chinese medicine composition of eyesight and preparation method thereof, for raw material and suitable weight proportion is carried out by using the fruit of Chinese wolfberry, Radix Angelicae Sinensis, chrysanthemum, peppermint, butterflybush flower, cassia seed, pearl powder and Moschus, what is be prepared is used to improve the Chinese medicine composition of eyesight, there is nourishing qi and blood, dredging collateral improving eyesight, it is high efficiency, quick, without side-effects for improving the significant effect of eyesight.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its preparation side for being used to improve eyesight
Method.
Background technology
With China's modernization development, while whole people's know-how improves, the eyesight of people is and then begun to decline, and is worn
The ratio of glasses is also higher and higher, is especially showed in population of adolescent the most apparent；According to statistics, pupil wears glasses
Ratio 20% or so, the ratio that middle school student wear glasses 30% or so, the ratio that high school student wears glasses 40% or so,
And this ratio also increases constantly.Teenager's visual impairment has certain rule of development：Learning burden weight --- study
Time and --- --- eyesight temporarily declines --- catching up with study schedule ---, and eye looks the books time to asthenopia with eye time lengthening
Long --- eyesight recoverability declines --- learning efficiency decline --- continuing increase eye learning time --- eyesight not recoverability
Decline, the vicious circle of this development causes teenager's visual impairment increasingly severe, not only influences study and life usually
It is living, it is also totally unfavorable to the total health development of teenager's body.
At present, the method for eyesight is improved by very much, and such as wearing spectacles, using health-care appliance, operative treatment and use are near several
Contact lenses risen on the market over year etc..Although the effect of these methods is fast, there is very big security risk.It wears glasses,
It can see object clearly at once, but for visual impairment the problem of does not obtain solution fundamentally, and long periods of wear can cause eye
The problems such as nest sink and is dizzy；Although some effects of health-care appliance, cannot cure, and easily recur and aggravate the state of an illness；Operation
Treatment is gone to the hospital and is all treated using the operation method of laser cutting, easily causes operation risk, there is excessively correction or low correction,
And after operation 5-6, thick cocoon is easily formed at surgical wound, causes the disastrous effect that eyesight is worse；Contact lens, students in middle and primary schools are just
In growth and development vigorous period, the eyeball optical axis is not yet shaped, if too early or long period continuous contact lens, are also easy to produce
The side effects such as cornea anoxic and physiological metabolism obstacle, lens cleaning disinfection it is not tight, then can scabies secondary infection, if eyeglass labyrinth and cornea
It is incompatible, corneal abrasion, exuviation can be also caused, severe patient can cause ulcer of the cornea or perforation.Therefore, these methods are all
It is palliative, for visual impairment the problem of does not obtain solution fundamentally.
The content of the invention
In order to solve the above problem existing in the prior art, the present invention provides a kind of high efficiency, it is quick, without pair make
For improving Chinese medicine composition of eyesight and preparation method thereof.The Chinese medicine composition has nourishing qi and blood, dredging collateral improving eyesight
The effect of, the Chinese medicine composition is used to improve the significant effect of eyesight.
The technical solution adopted in the present invention is：
A kind of Chinese medicine composition for being used to improve eyesight, raw material components include：
It is fruit of Chinese wolfberry 10-30 parts by weight, Radix Angelicae Sinensis 10-20 parts by weight, chrysanthemum 10-20 parts by weight, peppermint 10-20 parts by weight, close
Cover flower 10-20 parts by weight, cassia seed 10-15 parts by weight, pearl powder 5-15 parts by weight, Moschus 1-3 parts by weight.
The raw material components of the further preferably Chinese medicine composition for improving eyesight include：
It is fruit of Chinese wolfberry 18-22 parts by weight, Radix Angelicae Sinensis 12-18 parts by weight, chrysanthemum 12-18 parts by weight, peppermint 12-18 parts by weight, close
Cover flower 12-18 parts by weight, cassia seed 11-13 parts by weight, pearl powder 8-12 parts by weight, Moschus 1.5-2.5 parts by weight.
The raw material components of the further preferably Chinese medicine composition for improving eyesight include：
20 parts by weight of the fruit of Chinese wolfberry, 15 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of chrysanthemum, 15 parts by weight of peppermint, 15 parts by weight of butterflybush flower,
12 parts by weight of cassia seed, 10 parts by weight of pearl powder, 2 parts by weight of Moschus.
It is a kind of to prepare the method for being used to improve the Chinese medicine composition of eyesight, include the following steps：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, after drying, crushing, obtains chrysanthemum fine powder, after into the chrysanthemum fine powder water being added to be impregnated, then into
Row distillation extraction collects the oily mater in distillation condensate liquid to get the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, peppermint fine powder is obtained, petroleum ether and ethyl alcohol is added in into the peppermint fine powder, into
It after row impregnates, adds water and carries out distillation extraction, collect extracting solution and be filtered, filtrate removes organic solvent to get described thin
Lotus volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, are mixed after being separately dried, crushing, are obtained mixture
Material adds in 8-10 times of quality water into the mixed material, is decocted, and merges decoction liquor, after filtered, concentration, is carried
Take liquid；
(4) pearl powder and Moschus are added in vaseline, stirred evenly, be heated to melting, after sterilized processing, successively
The volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution is added in be sufficiently mixed uniformly to get described for improving in eyesight
Drug composition.
In step (1), the temperature of the drying is carried out as 60-90 DEG C, and the time for carrying out the drying is 1-6h.
In step (1), the grain size of the chrysanthemum fine powder is 300-500 mesh；The chrysanthemum fine powder with addition water quality it
Than for 1:8-1:12；
The temperature for carrying out the distillation extraction is 100-120 DEG C, and the time for carrying out the distillation extraction is 3-5h.
In step (2), the grain size of the peppermint fine powder is 300-500 mesh, the quality of the peppermint fine powder and petroleum ether it
Than for 1:1-1:1.2, the mass ratio of the peppermint fine powder and ethyl alcohol is 1:0.5-1:1；
The time of the immersion is carried out as 1-2h, the mass ratio of the peppermint fine powder and addition water is 1:2-1:4；
The temperature for carrying out the distillation extraction is 80-100 DEG C, and the time for carrying out the distillation extraction is 0.5-1.5h.
In step (3), the grain size of the mixed material is 300-500 mesh；
The addition quality of water and the mass ratio of mixed material are 8:1-10:1.
In step (3), 1/10-1/12 is concentrated into.
In step (4), the heating temperature of the vaseline is 140-160 DEG C.
For the ease of understanding the present invention, the raw material in the present invention and drug effect are further elaborated below.
The fruit of Chinese wolfberry, it is sweet in flavor, it is mild-natured.Nourishing liver and kidney, benefiting shrewd head.With controlling consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, interior
Heat is quenched one's thirst, blood deficiency chlorosis, blurred vision.
Radix Angelicae Sinensis, it is sweet in flavor, pungent, it is warm-natured.Replenishing and activating blood, menstruction regulating and pain relieving relax bowel.With controlling blood deficiency chlorosis, dizziness palpitaition, the moon
Through uncomfortable, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.
Chrysanthemum, sweet in flavor, bitter, cold nature.Relieve heat heat-clearing, flat liver improving eyesight.For anemopyretic cold, dizziness of having a headache, red eye, swell pain,
Eyes is dim-sighted.
Peppermint, acrid flavour are cool in nature.Dispelling wind-heat, refresh oneself, promoting eruption.Ached with the wind-heat that cures cold, headache, hot eyes, pharyngitis
Bitterly, pruitus, measles without adequate eruption etc..
Butterflybush flower, sweet in flavor, cold nature.Heat-clearing nourishing the liver purging intense heat, removing nebula.With controlling red eye, swell pain, more tear photophobia, screen of looking unfamiliar
Film, hepatasthenia dim eyesight, blurring of vision.
Cassia seed, bitter, sweet, cold nature.Heat-clearing improving eyesight relaxes bowel.With control attacked in the fire of deficiency type or wind-heat of liver channel etc. caused by
The more tears of red eye, swell pain, photophobia and yctalopia；Constipation with heat retention, dry constipation of intestines；Dizziness headache of liver-yang hyperactivity etc..
Pearl powder, it is sweet in flavor, salty, it is cold in nature.Calm the nerves arresting convulsion, improving eyesight disappears screen, solves taking poison and growing muscle due.For insomnia of palpitating with fear, infantile convulsion epilepsy,
Mesh gives birth to cloudiness, and sore is not held back.
Moschus, acrid flavour are warm-natured.Inducing resuscitation of having one's ideas straightened out, invigorate blood circulation, swelling and pain relieving.For pyreticosis coma, apoplexy coma due to blocking of the respiratory system, the obstruction of the circulation of vital energy
It faints cruelly, middle evil is gone into a coma, Amenorrhea , wei lumps in the abdomen, stillborn foetus of having difficult labour, trusted subordinate sudden and violent pain, carbuncle swells scrofula, abscess of throat, the pain of injury caused by falling and tumbling, numbness pain fiber crops
Wood.
Beneficial effects of the present invention are：
It is of the present invention for improving the Chinese medicine composition of eyesight, by using the fruit of Chinese wolfberry, Radix Angelicae Sinensis, chrysanthemum, peppermint, close
Flower, cassia seed, pearl powder, Moschus are covered as raw material and carries out suitable weight proportion, what is be prepared is used to improve in eyesight
Drug composition has effects that nourishing qi and blood, dredging collateral improving eyesight, for improving the significant effect of eyesight, high efficiency, it is quick,
It is without side-effects.
Specific embodiment
With reference to embodiment, the invention will be further described.
In example below 1g is represented with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of for improving the Chinese medicine composition of eyesight, raw material components include：
10 parts by weight of the fruit of Chinese wolfberry, 20 parts by weight of Radix Angelicae Sinensis, 10 parts by weight of chrysanthemum, 20 parts by weight of peppermint, 10 parts by weight of butterflybush flower,
15 parts by weight of cassia seed, 5 parts by weight of pearl powder, 3 parts by weight of Moschus.
Further, the present invention provides a kind of described for improving the preparation method of the Chinese medicine composition of eyesight, including as follows
Step：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, is crushed after 60 DEG C of dry 6h, the chrysanthemum fine powder that grain size is 300 mesh is obtained, into the chrysanthemum fine powder
After 8 times of quality water is added to be impregnated, then carry out at 100 DEG C distillation extraction 5h, collect the oily mater in distillation condensate liquid to get
The volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, the peppermint fine powder that grain size is 300 mesh is obtained, 1 is added in into the peppermint fine powder
Times petroleum ether of quality and the ethyl alcohol of 0.5 times of quality after carrying out immersion 1h, add 2 times of quality water distillation are carried out at 80 DEG C and carry
1.5h is taken, extracting solution is collected and is filtered, filtrate removes petroleum ether and ethyl alcohol to get the Herba Menthae Haplocalycis volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, is mixed after being separately dried, crushing, and obtaining grain size is
The mixed material of 300 mesh adds in 8 times of quality water into the mixed material, is decocted, and merges decoction liquor, filtered, concentration
To after 1/10, extracting solution is obtained；
(4) pearl powder and Moschus is taken to be added in vaseline, is stirred evenly, being heated to 140 DEG C makes its melting, sterilized place
After reason, sequentially add the volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution and be sufficiently mixed uniformly to get described for carrying
The Chinese medicine composition of high eyesight.
Embodiment 2
The present embodiment provides a kind of for improving the Chinese medicine composition of eyesight, raw material components include：
30 parts by weight of the fruit of Chinese wolfberry, 10 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of chrysanthemum, 10 parts by weight of peppermint, 20 parts by weight of butterflybush flower,
10 parts by weight of cassia seed, 15 parts by weight of pearl powder, 1 parts by weight of Moschus.
Further, the present invention provides a kind of described for improving the preparation method of the Chinese medicine composition of eyesight, including as follows
Step：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, is crushed after 90 DEG C of dry 1h, the chrysanthemum fine powder that grain size is 500 mesh is obtained, into the chrysanthemum fine powder
After 12 times of quality water is added to be impregnated, then distillation extraction 3h is carried out at 120 DEG C, collect the oily mater in distillation condensate liquid, i.e.,
Obtain the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, the peppermint fine powder that grain size is 500 mesh is obtained, is added in into the peppermint fine powder
The petroleum ether of 1.2 times of quality and the ethyl alcohol of 1 times of quality, after carrying out immersion 2h, add 4 times of quality water and are distilled at 100 DEG C
0.5h is extracted, extracting solution is collected and is filtered, filtrate removes petroleum ether and ethyl alcohol to get the Herba Menthae Haplocalycis volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, is mixed after being separately dried, crushing, and obtaining grain size is
The mixed material of 500 mesh adds in 10 times of quality water into the mixed material, is decocted, and merges decoction liquor, filtered, dense
After being reduced to 1/12, extracting solution is obtained；
(4) pearl powder and Moschus is taken to be added in vaseline, is stirred evenly, being heated to 160 DEG C makes its melting, sterilized place
After reason, sequentially add the volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution and be sufficiently mixed uniformly to get described for carrying
The Chinese medicine composition of high eyesight.
Embodiment 3
The present embodiment provides a kind of for improving the Chinese medicine composition of eyesight, raw material components include：
18 parts by weight of the fruit of Chinese wolfberry, 18 parts by weight of Radix Angelicae Sinensis, 12 parts by weight of chrysanthemum, 18 parts by weight of peppermint, 12 parts by weight of butterflybush flower,
13 parts by weight of cassia seed, 8 parts by weight of pearl powder, 2.5 parts by weight of Moschus.
Further, the present invention provides a kind of described for improving the preparation method of the Chinese medicine composition of eyesight, including as follows
Step：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, is crushed after 75 DEG C of dry 3.5h, the chrysanthemum fine powder that grain size is 400 mesh is obtained, to the chrysanthemum fine powder
In plus after 10 times of quality water are impregnated, then distillation extraction 4h is carried out at 110 DEG C, collects the oily mater in distillation condensate liquid,
Up to the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, the peppermint fine powder that grain size is 400 mesh is obtained, is added in into the peppermint fine powder
The petroleum ether of 1.1 times of quality and the ethyl alcohol of 0.75 times of quality after carrying out immersion 1.5h, add 3 times of quality water in 90 DEG C of progress
Distillation extraction 1h, collects extracting solution and is filtered, and filtrate removes petroleum ether and ethyl alcohol to get the Herba Menthae Haplocalycis volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, is mixed after being separately dried, crushing, and obtaining grain size is
The mixed material of 400 mesh adds in 9 times of quality water into the mixed material, is decocted, and merges decoction liquor, filtered, concentration
To after 1/11, extracting solution is obtained；
(4) pearl powder and Moschus is taken to be added in vaseline, is stirred evenly, being heated to 150 DEG C makes its melting, sterilized place
After reason, sequentially add the volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution and be sufficiently mixed uniformly to get described for carrying
The Chinese medicine composition of high eyesight.
Embodiment 4
The present embodiment provides a kind of for improving the Chinese medicine composition of eyesight, raw material components include：
22 parts by weight of the fruit of Chinese wolfberry, 12 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of chrysanthemum, 12 parts by weight of peppermint, 18 parts by weight of butterflybush flower,
11 parts by weight of cassia seed, 12 parts by weight of pearl powder, 1.5 parts by weight of Moschus.
Further, the present invention provides a kind of described for improving the preparation method of the Chinese medicine composition of eyesight, including as follows
Step：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, is crushed after 75 DEG C of dry 3.5h, the chrysanthemum fine powder that grain size is 400 mesh is obtained, to the chrysanthemum fine powder
In plus after 10 times of quality water are impregnated, then distillation extraction 4h is carried out at 110 DEG C, collects the oily mater in distillation condensate liquid,
Up to the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, the peppermint fine powder that grain size is 400 mesh is obtained, is added in into the peppermint fine powder
The petroleum ether of 1.1 times of quality and the ethyl alcohol of 0.75 times of quality after carrying out immersion 1.5h, add 3 times of quality water in 90 DEG C of progress
Distillation extraction 1h, collects extracting solution and is filtered, and filtrate removes petroleum ether and ethyl alcohol to get the Herba Menthae Haplocalycis volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, is mixed after being separately dried, crushing, and obtaining grain size is
The mixed material of 400 mesh adds in 9 times of quality water into the mixed material, is decocted, and merges decoction liquor, filtered, concentration
To after 1/11, extracting solution is obtained；
(4) pearl powder and Moschus is taken to be added in vaseline, is stirred evenly, being heated to 150 DEG C makes its melting, sterilized place
After reason, sequentially add the volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution and be sufficiently mixed uniformly to get described for carrying
The Chinese medicine composition of high eyesight.
Embodiment 5
The present embodiment provides a kind of for improving the Chinese medicine composition of eyesight, raw material components include：
20 parts by weight of the fruit of Chinese wolfberry, 15 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of chrysanthemum, 15 parts by weight of peppermint, 15 parts by weight of butterflybush flower,
12 parts by weight of cassia seed, 10 parts by weight of pearl powder, 2 parts by weight of Moschus.
Further, the present invention provides a kind of described for improving the preparation method of the Chinese medicine composition of eyesight, including as follows
Step：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, is crushed after 75 DEG C of dry 3.5h, the chrysanthemum fine powder that grain size is 400 mesh is obtained, to the chrysanthemum fine powder
In plus after 10 times of quality water are impregnated, then distillation extraction 4h is carried out at 110 DEG C, collects the oily mater in distillation condensate liquid,
Up to the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, the peppermint fine powder that grain size is 400 mesh is obtained, is added in into the peppermint fine powder
The petroleum ether of 1.1 times of quality and the ethyl alcohol of 0.75 times of quality after carrying out immersion 1.5h, add 3 times of quality water in 90 DEG C of progress
Distillation extraction 1h, collects extracting solution and is filtered, and filtrate removes petroleum ether and ethyl alcohol to get the Herba Menthae Haplocalycis volatile oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, is mixed after being separately dried, crushing, and obtaining grain size is
The mixed material of 400 mesh adds in 9 times of quality water into the mixed material, is decocted, and merges decoction liquor, filtered, concentration
To after 1/11, extracting solution is obtained；
(4) pearl powder and Moschus is taken to be added in vaseline, is stirred evenly, being heated to 150 DEG C makes its melting, sterilized place
After reason, sequentially add the volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution and be sufficiently mixed uniformly to get described for carrying
The Chinese medicine composition of high eyesight.
Experimental example
1st, the using effect analysis of 3 gained Chinese medicine composition of the embodiment of the present invention
Application method：0.3-0.5g Chinese medicine compositions are taken, is mixed thoroughly, embrocated in eyes of patients in the left hand centre of the palm with right hand forefinger
Around, it is using eyeball as the center of circle to embrocate scope, and radius draws circle for 3cm, after mesh being closed after embrocating 30 minutes, is opened eyes, after one hour again
Eye circumference is enclosed clean.It embrocates twice daily.
By the way that 110 clinical observations are proved with have more significant health care to rectify visual effect teenager and school-ager's pseudo-myopia
Fruit.Clinical observation case and the results are shown in Table 1.
Table 1- clinical cases
Overall health-care effect is as shown in table 2.
Table 2- totality health-care effects
2nd, the acute dermal toxicity detection of 3 gained Chinese medicine composition of the embodiment of the present invention
Experimental animal：SD strains big white mouse 20, each 10 of male and female, weight 180-220g, by Xian Medical Univ animal
Raising center provides.
Tested material：3 gained Chinese medicine composition of the embodiment of the present invention.
Test method：Big white mouse is taken, its back wool is sloughed, depilation scope is the 10% of its body surface area.By tested material
By the dosage of 1.0/100g, experiment mouse depilation position is applied, 24 it is small when after, warm water removes residual tested material, continuous to see
It examines 7 days.
Result of the test：Experiment mouse whole body anomalous variation is had no in observation period, experiment mouse does not also occur the phenomena of mortality, after coating
The reactions such as part has no red and swollen, festers, inflammation necrosis.
Evaluation of result：Chinese medicine composition of the present invention belongs to actual nontoxic grade.
3rd, the sensitivity response detection of 3 gained Chinese medicine composition of the embodiment of the present invention
Experimental animal：Britain cavy 30, weight 200-220g, each 15 of male and female, by The Fourth Military Medical University's animal feeding
Center provides.
Tested material：3 gained Chinese medicine composition of the embodiment of the present invention.
Test method：Guinea pig back diamond wool is taken off when before administration 24 is small, unhairing scope is per side about 3*3cm2.It will examination
It tests cavy and is randomly divided into three groups by weight, gender, every group 10, each 15 of male and female, first group is put to the test, and second group of feminine gender is right
According to the 3rd group is positive control.
Sensitization contact：Tested material 0.2g is taken to be coated in back hair removal section on the left of animal, continue 6 it is small when, the 7th day and the 14th day,
It is in kind repeated once, negative control applies distilled water, and positive control applies 0.1%DNCB.
Excitation contact：In last to 14 days after tested material sensitization, tested material 0.2g is applied to hair removal section on the left of guinea pig back,
6 it is small when after remove tested material, at once observe allergic reaction situation, then observed again when 1,24,28 is small, negative control group
(distilled water) and positive controls (0.1%DNCB), operation is with observation method with by medicine group.
Result of the test is as shown in table 3.
Table 3- sensitivity responses are scored
From table 3 it can be seen that Chinese medicine composition of the present invention is without sensitization.
4th, the Skin Irritation Test of 3 gained Chinese medicine composition of the embodiment of the present invention
Experimental animal：New zealand white rabbit three, weight 2.5*0.5kg, is carried by Xian Medical Univ's animal feeding center
For.
Tested material：3 gained Chinese medicine composition of the embodiment of the present invention.
Test method：Take before the administration of new zealand white rabbit three 24 it is small when by each unhairing 3* in rabbit back spine column both sides
2cm2, take tested material 1.0g/ only, even application material, with adhesive plaster, opposite side applies distilled water as blank control, after coating 4 it is small when
Residual tested material, local skin response situation when observation 1,24,48,72 is small are removed with warm water.
Result of the test is as shown in table 4.
Table 4- skin wound repair appraisal results
From table 4, it can be seen that Chinese medicine composition of the present invention is to no skin irritation.
5th, the performance detection promoting blood circulation and removing blood stasis of 3 gained Chinese medicine composition of the embodiment of the present invention
Experimental animal：TCR Strains of Mouse 30, weight 20-25g, each 15 of male and female, The Fourth Military Medical University's animal center carries
For.
Reagent：Yellow Jackets, upper sea-run Zhi Hua formulas factory produce, and it is spare to be made into 1% concentration for lot number 9211019；Adrenal gland
It is spare to be made into 0.1% for element.East blood-activating cream, east pharmaceutical factory production, makees positive control.
Method：30 mouse are randomly divided into 3 groups, every group 10, modeling control group is a little per mouse auris dextra painting physiological saline；
The east blood-activating cream of positive controls left ear painting heating per mouse is a little；Administration group applies Chinese medicine composition of the present invention.After 15min
1% yellow Jackets 0.1ml/10g, anesthetized animal is injected intraperitoneally, subsequent 0.1 adrenaline 0.1ml/10g of tail vein injection is stood
Observe ear fine motion vein bore and 1mm2Capillary vessel number, T examine processing experimental data.
Influence of the table 5- Chinese medicine compositions of the present invention to mouse ear fine motion vein bore and capillary open number
As can be seen from the above table, pharmaceutical composition of the present invention is to fine motion, vein bore and capillary open number
There is increasing action, illustrate that there is effect promoting blood circulation and removing blood stasis.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the enlightenment of the present invention
The product of form, however, make any variation in its shape or structure, it is every that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for being used to improve eyesight, which is characterized in that raw material components include：
Fruit of Chinese wolfberry 10-30 parts by weight, Radix Angelicae Sinensis 10-20 parts by weight, chrysanthemum 10-20 parts by weight, peppermint 10-20 parts by weight, butterflybush flower
10-20 parts by weight, cassia seed 10-15 parts by weight, pearl powder 5-15 parts by weight, Moschus 1-3 parts by weight.
2. the Chinese medicine composition according to claim 1 for being used to improve eyesight, which is characterized in that raw material components include：
Fruit of Chinese wolfberry 18-22 parts by weight, Radix Angelicae Sinensis 12-18 parts by weight, chrysanthemum 12-18 parts by weight, peppermint 12-18 parts by weight, butterflybush flower
12-18 parts by weight, cassia seed 11-13 parts by weight, pearl powder 8-12 parts by weight, Moschus 1.5-2.5 parts by weight.
3. the Chinese medicine composition according to claim 1 for being used to improve eyesight, which is characterized in that raw material components include：
20 parts by weight of the fruit of Chinese wolfberry, 15 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of chrysanthemum, 15 parts by weight of peppermint, 15 parts by weight of butterflybush flower, Cassia
Sub 12 parts by weight, 10 parts by weight of pearl powder, 2 parts by weight of Moschus.
4. a kind of prepare claim 1-3 any one of them for improving the method for the Chinese medicine composition of eyesight, feature exists
In including the following steps：
(1) volatile oil of chrysanthemum extracts：
Chrysanthemum is taken, after drying, crushing, chrysanthemum fine powder is obtained, after into the chrysanthemum fine powder water being added to be impregnated, then is steamed
Extraction is evaporated, collects the oily mater in distillation condensate liquid to get the volatile oil of chrysanthemum；
(2) Herba Menthae Haplocalycis volatile oil extracts：
Peppermint is taken, after drying, crushing, peppermint fine powder is obtained, petroleum ether and ethyl alcohol is added in into the peppermint fine powder, is soaked
It after bubble, adds water and carries out distillation extraction, collect extracting solution and be filtered, filtrate removes organic solvent and waved to get the peppermint
Hair oil；
(3) extracting solution is prepared：
The fruit of Chinese wolfberry, Radix Angelicae Sinensis, butterflybush flower and cassia seed are weighed respectively, are mixed after being separately dried, crushing, are obtained mixed material, to
8-10 times of quality water is added in the mixed material, is decocted, merges decoction liquor, after filtered, concentration, obtains extracting solution；
(4) pearl powder and Moschus are added in vaseline, stirred evenly, be heated to melting, after sterilized processing, sequentially added
The volatile oil of chrysanthemum, Herba Menthae Haplocalycis volatile oil, extracting solution are sufficiently mixed uniformly to get the Chinese medicine group for being used to improve eyesight
Close object.
5. preparation method according to claim 4, which is characterized in that in step (1), the temperature for carrying out the drying is
60-90 DEG C, the time for carrying out the drying is 1-6h.
6. the preparation method of the Chinese medicine composition according to claim 4 for being used to improve eyesight, which is characterized in that step
(1) in, the grain size of the chrysanthemum fine powder is 300-500 mesh；The mass ratio of the chrysanthemum fine powder and addition water is 1:8-1:12；
The temperature for carrying out the distillation extraction is 100-120 DEG C, and the time for carrying out the distillation extraction is 3-5h.
7. the preparation method of the Chinese medicine composition according to claim 4 for being used to improve eyesight, which is characterized in that step
(2) in, the grain size of the peppermint fine powder is 300-500 mesh, and the mass ratio of the peppermint fine powder and petroleum ether is 1:1-1:
1.2, the mass ratio of the peppermint fine powder and ethyl alcohol is 1:0.5-1:1；
The time of the immersion is carried out as 1-2h, the mass ratio of the peppermint fine powder and addition water is 1:2-1:4；
The temperature for carrying out the distillation extraction is 80-100 DEG C, and the time for carrying out the distillation extraction is 0.5-1.5h.
8. the preparation method of the Chinese medicine composition according to claim 4 for being used to improve eyesight, which is characterized in that step
(3) in, the grain size of the mixed material is 300-500 mesh；
The addition quality of water and the mass ratio of mixed material are 8:1-10:1.
9. the preparation method of the Chinese medicine composition according to claim 8 for being used to improve eyesight, which is characterized in that step
(3) in, it is concentrated into 1/10-1/12.
10. the preparation method of the Chinese medicine composition according to claim 4 for being used to improve eyesight, which is characterized in that step
(4) in, the heating temperature of the vaseline is 140-160 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109806396A (en) * | 2019-03-08 | 2019-05-28 | 上海明恺中医药技术有限公司 | A kind of external application type acupuncture point plaster formula for alleviating asthenopia |
| CN112190630A (en) * | 2020-10-23 | 2021-01-08 | 四川福怡长者文化传播有限公司 | Eye ointment for regulating eyesight and preparation method thereof |
| CN113144013A (en) * | 2021-04-19 | 2021-07-23 | 上海眸动力生物科技有限公司 | Medicine for relieving dry eye and preparation method thereof |
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| CN1217922A (en) * | 1997-11-21 | 1999-06-02 | 宋百一 | Visual acuity health-care paste and preparation and usage |
| CN101380395A (en) * | 2008-10-22 | 2009-03-11 | 李华鹏 | Traditional Chinese medicine composition for preventing and treating ophthalmic diseases and preparation method thereof |
| KR20110054579A (en) * | 2009-11-18 | 2011-05-25 | 강홍구 | Herbal medicine composite and pill for ophthalmic fatigue relief and eyesight recovery |
| CN106309726A (en) * | 2016-09-18 | 2017-01-11 | 马利忠 | Eye beautifying and eyesight improving nutritional agent and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1217922A (en) * | 1997-11-21 | 1999-06-02 | 宋百一 | Visual acuity health-care paste and preparation and usage |
| CN101380395A (en) * | 2008-10-22 | 2009-03-11 | 李华鹏 | Traditional Chinese medicine composition for preventing and treating ophthalmic diseases and preparation method thereof |
| KR20110054579A (en) * | 2009-11-18 | 2011-05-25 | 강홍구 | Herbal medicine composite and pill for ophthalmic fatigue relief and eyesight recovery |
| CN106309726A (en) * | 2016-09-18 | 2017-01-11 | 马利忠 | Eye beautifying and eyesight improving nutritional agent and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109806396A (en) * | 2019-03-08 | 2019-05-28 | 上海明恺中医药技术有限公司 | A kind of external application type acupuncture point plaster formula for alleviating asthenopia |
| CN112190630A (en) * | 2020-10-23 | 2021-01-08 | 四川福怡长者文化传播有限公司 | Eye ointment for regulating eyesight and preparation method thereof |
| CN113144013A (en) * | 2021-04-19 | 2021-07-23 | 上海眸动力生物科技有限公司 | Medicine for relieving dry eye and preparation method thereof |
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