CN105342966B - Skin care moisturiser containing Hirudo japonica and preparation method thereof - Google Patents
Skin care moisturiser containing Hirudo japonica and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61Q19/00—Preparations for care of the skin
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Abstract
This patent discloses the skin care moisturisers containing Hirudo japonica, are made of the raw material components of its following mass fraction, A phases：1.5 3.5 parts of octadecyl alcolol, 0.2 0.4 parts of Butylated Hydroxytoluene, 0.5 2.5 parts of isomery hexadecane, 0.5 3 parts of isopropyl myristate, 24 parts of glycerol stearate ester admixture, 0.1 0.4 parts of olive oil, 15 parts of caprylic/capric triglyceride；B phases：55 65 parts of deionized water, 5 10 parts of glycerine；C phases：14 parts of dimethyl silicone polymer, 0.8 2.5 parts of 13 mixture of polyacrylate；D phases：5 15 parts of deionized water, 1 2.5 parts of glycine betaine, 14 parts of biological polyoses glue, 14 parts of niacinamide, 0.2 0.5 parts of aloe gel spray dried powder, 0.05 0.3 parts of Radix Paeoniae Alba medicament extracting solution, 0.05 0.3 parts of angelica extract, 0.05 0.3 parts of crocus sativus, 0.1 0.5 parts of Hirudo japonica extract, 0.05 0.3 parts of Ginseng extract；E phases：0.2 0.5 parts of pentanediol, 0.2 0.5 parts of vitamin E, 0.5 0.8 parts of Phenoxyethanol.The technical problem to be solved in the present invention is to provide good skin care moisturisers containing Hirudo japonica of a kind of moistening effect and preparation method thereof.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of skin care moisturiser containing Hirudo japonica and its preparation side
Method.
Background technology
Skin care is always the intersection point of many women concerns of liking to be beautiful, they can spend substantial amounts of money and time to do the guarantor of skin
It supports.Skin moisture-keeping, when air themperature reduces, keratoderma cannot adjust enough moisturizing factors in time, and grease gland enlivens
Degree declines, and grease, moisture decline on the face, and skin is present with tight phenomenon, even now and nose branch shows microgroove, by using
Skin care with corresponding effect, foster skin product, skin care simultaneously prevent skin evaporation, improve microcirculation, enhancing skin wettability
Process is just named moisturizing, and best moisturizing is exactly the good interaction of skin and moisturizing product.At present, on the market moisturizer from washing
Face milk, toner, Essence to moisturiser, can play the role of moisturizing to a certain extent.
Hirudo japonica cures the animal of leech category, popular name hirudo nipponica, leech, line leech, leech, Japan's doctor's water for Yi Zhi sections
Leech；Be distributed in Japan, the Far East Area of Russia, Mongolia and China's Mainland North gets northeast each province, the Inner Mongol, west to four
The ground such as river, Gansu, Nan Da Guangdong are generally inhabited in paddy field and its irrigation canals and ditches communicated therewith, pond and marsh and are particularly
Quantity is most in long-term ponding or the waterlogged plot of impeded drainage and field heart.It was found that it is separated from Hirudo japonica and identifies 8
Compound, structure are respectively：Campesterol (campesterol), hexadecyl-glyceryl ether, (2S, 3S, 4E) -4,5- two are de-
18 sphingol hyenic acid fatty acid amide of hydrogen, 1-O- β-D- glucopyranosyls -2-N- (two dodecanoyls)-E-4,5- bis-
18 cerebroside (4) of dehydrogenation -3- hydroxyls, succinic acid (5), hypoxanthine (6), alanine (7), isoleucine (8) etc., inventor
During Hirudo japonica is studied, it is found that moisturiser is made with other moisturizing ingredient compatibilities in it, there is unexpected guarantor
Wet effect.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of good skin care moisturisers containing Hirudo japonica of moistening effect
And preparation method thereof.
In order to solve the above technical problem, the present invention provides following basic technology schemes：Skin care containing Hirudo japonica is protected
Wet frost is made of the raw material components of its following mass fraction,
A phases：1.5-3.5 parts of octadecyl alcolol, 0.2-0.4 parts of Butylated Hydroxytoluene, 0.5-2.5 parts of isomery hexadecane, myristic acid are different
0.5-3 parts of propyl ester, 2-4 parts of glycerol stearate ester admixture, 0.1-0.4 parts of olive oil, 1-5 parts of caprylic/capric triglyceride；
B phases：55-65 parts of deionized water, 5-10 parts of glycerine；
C phases：1-4 parts of dimethyl silicone polymer, 0.8-2.5 parts of -13 mixture of polyacrylate；
D phases：5-15 parts of deionized water, 1-2.5 parts of glycine betaine, 1-4 parts of biological polyoses glue, 1-4 parts of niacinamide, aloe gel
0.2-0.5 parts of spray dried powder, 0.05-0.3 parts of Radix Paeoniae Alba medicament extracting solution, 0.05-0.3 parts of angelica extract, crocus sativus
0.05-0.3 parts, 0.1-0.5 parts of Hirudo japonica extract, 0.05-0.3 parts of Ginseng extract；
E phases：0.2-0.5 parts of pentanediol, 0.2-0.5 parts of vitamin E, 0.5-0.8 parts of Phenoxyethanol.
Using the skin care moisturiser containing Hirudo japonica of technical solution of the present invention, A phases, octadecyl alcolol is surfactant,
It is the common moisturizer of cosmetics；Butylated Hydroxytoluene, molecular formula C15H240, relative molecular mass 220.35, be white crystals or
Crystalline powder, tasteless or slightly particularity smell, 69.7 DEG C of fusing point, 265 DEG C of boiling point, to thermostabilization, with Action of Metal Ions
It will not colour, be common oil antioxidant.Isomery hexadecane, isohexadecane are mainly the mixture of isoparaffin C16, are contained
There are the isoparaffin of a small amount of C12 and C20, the liquid of colorless and odorless has good thermal stability and oxidation stability, mainly
It is used in high performance cosmetics and personal care articles.Isopropyl myristate is widely used in cosmetics, can play guarantor
Wet and skin care effect, skin is preferable to the absorbability of this product, can effectively be contacted with hair follicle in cortex, and it is deep to penetrate into cortex
Place, and the active component in cosmetics is brought into, give full play to the effect of active ingredient.Stearine the ingredients of a mixture
Predominantly stearine, cetostearyl alcohol, stearoyl dilactic acid sodium, contained ingredient is similar to skin, stearoyl breast
City imitates the sweller of high HBL in skin to sour sodium in chemistry, such as cholesterol sulfate and phosphatide, and cetostearyl alcohol and glycerine
Stearate imitates hydrophobic free fatty, cholesterol and ceramide, due to combining in the proper ratio, this breast
Agent, which has skin, rebuilds skin keratin layer function, improves moisture retention, the water-resistance of skin, tender, smooth and glossy, and subtracts
Scattering and disappearing for few active ingredient, makes active ingredient preferably play effect.Olive oil is by the fresh direct cold press of olive fruit
It forms, not heated and chemical treatment remains natural nutrient component.Olive oil is considered as in the grease found so far
It is most suitable for the grease of human nutrition.Caprylic/capric triglyceride, it is clear extremely faint yellow, it is that height clearly spends tasteless grease, belongs to palm
The derivative of oil or coconut oil, it is easy to be absorbed by the skin, play the role of to the uniform and smooth of cosmetics good, moisten skin
Cunning has light.B phases, deionized water, deionized water refer to eliminate the pure water in after ionic species impurity.International Organization for standardization
" deionization " is defined as defined in ISO/TC 147：" deionized water is complete or incompletely removes ionic species." present work
Skill is mainly produced using the reverse osmosis methods of RO；Glycerine, glycerine is colourless sweet clear and bright thick liquid, odorless, there is warm sweet taste,
Glycerine is commonly called as, moisture can be absorbed from air.C phases, dimethyl silicone polymer, in addition to directly use, in order to make methyl-silicone oil point
Dissipate, convenient for dipping, spraying, improve efficiency, also can wiring solution-forming type, lipid, emulsion-type three types use, with derivative
All it is the quality raw materials of cosmetics, there is good skin-protecting function, belong to the Synthetic Oil in cosmetic material.Polyacrylic acid
The main component of -13 mixture of ester is：Polyacrylate -13, polyisobutene and polysorbate -20 quick-acting can thicken, and stablize
Property good, ambient operation, broad pH value range be (pH=2.5-11), be smooth to the touch not sticky, the frost of emulsifier-free can be made
Shape gel, additive amount is low, to electrolyte better tolerance, the effect of property formula especially suitable for being rich in electrolyte.D phases, glycine betaine
A kind of alkaline matter, have strong moisture pick-up properties, biological polyoses glue have low-molecular-weight carbohydrate characteristic, moisture-absorbing moisture-keeping,
Long-acting moisturizing water lock effect is can reach, effect connected applications scope is wider, based on any system can add in
It moisturizing and assigns finished product more added values, especially emulsion system and does not increase viscosity, water-soluble adding ingredient is more easy to prescription behaviour
Make, effect and suitable system can be used for eye, sensitive skin, hair, body care, skin care, color make-up etc. all than wide；
Niacinamide be white crystals or crystalline powder, odorless or almost odorless, bitter.Aloe gel spray dried powder is from perennial lily
Juice (purified processing) obtained by the gravy part of section's Chinese aloe leaf, mainly there is an aloe-emodin, aloe anthrone, various saccharides,
The compositions such as enzyme, amino acid.For pistac liquid, relative density is 0.98~1.02, and pH value 4~6 is mainly used in cosmetics
Skin, hair protection articles for use, have moisturizing, sun-proof, deodorization, preventing obesity, softening skin, anti-inflammatory anti-itch, analgesic, anti-acne,
Freckle lightens the stain and other effects.It can also be used in medicine and food.Radix Paeoniae Alba medicament extracting solution is dicotyledon medicine ranunculaceae plant
The root of Chinese herbaceous peony (cultigen), root is thick thick sturdy, is traditional Chinese medicine, and Radix Paeoniae Alba is cold, bitter acid, have soft liver of enriching blood,
Smooth liver and relieve pain holds back cloudy receipts sweat and other effects, can treat the illnesss such as fever due to yin deficiency, irregular menstruation, diarrhea dysentery abdominal pain, moreover it is possible to invigorating qi and benefiting blood,
Whitening spot-removing.Angelica extract is a kind of for replenishing and activating blood, and menstruction regulating and pain relieving relaxes bowel, blood deficiency chlorosis, dizziness palpitaition, the moon
Through uncomfortable, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, the plant extracts of ulcer sores.Safranine
Flower is Asia west and south initial species, earliest by Greek's artificial cultivation, is mainly distributed on the ground such as Europe, Mediterranean and the Central Asia, bright
Towards when be passed to China,《Compendium of Materia Medica》It is included in the ground such as drug etc, Zhejiang Province, China plantation, is a kind of rare Chinese medicine
Material has powerful physiological activity, and column cap is medicinal in Asia and Europe conduct, has calmness, eliminating the phlegm, spasmolysis, for stomach
The treatment of disease, menstruation regulating, measles, fever, jaundice, hepatosplenomegaly etc..Ginseng extract, ginseng are described as " King of Herbs " and " are grown from ancient times
The moon mend life, strengthen the body resistance to consolidate the constitution " superfine product, containing a variety of saponins and polysaccharide constituents, leachate can be by skin slow-absorbing and without bad
It stimulates, capillary of skin can be expanded, promote skin blood Xun Huan, increase skin-nourishing, adjust the water and oil balance of skin, prevent
Skin dehydration, hardening, corrugation, ginseng active material inhibit the reducing property of melanin, make skin pure white smooth, can enhance skin
Elasticity obtains cell newborn, is the superfine product improved looks.E phases, pentanediol is the moisturizer haveing excellent performance, while is had anti-
Corruption effect can prepare the product of preservative free, reduce allergy caused by preservative；The water-resistance of sunscreen product formula can be improved；
The active ingredient of indissoluble is dissolved, for the various skin-protection products such as face cream, eye cream, surfactant, infant care product, sunscreen product
In.Vitamin E, vitamin E are the liposoluble vitamins for having 8 kinds of forms, are an important antioxidant, can be used in beauty side
Face.Phenoxyethanol is a kind of organic compound for being frequently used for skin-protection product, can be formed by ethylene glycol and menthylphenoxypolyethoxy ethanol, common
In face cream and suncream.
Moisturiser made of more than Multiple components shows that moistening effect is good according to zoopery and clinical test.
Preferred embodiment one, on base case, the mass fraction of the raw material components is：A phases：2.5 parts of octadecyl alcolol,
0.3 part of Butylated Hydroxytoluene, 1.5 parts of isomery hexadecane, 1 part of isopropyl myristate, 3 parts of glycerol stearate ester admixture, olive oil
0.3 part, 3 parts of caprylic/capric triglyceride；
B phases：59.1 parts of deionized water, 8 parts of glycerine；
C phases：2 parts of dimethyl silicone polymer, 1.6 parts of -13 mixture of polyacrylate；
D phases：10 parts of deionized water, 1.5 parts of glycine betaine, 2 parts of biological polyoses glue, 2 parts of niacinamide, aloe gel spray dried powder
0.3 part, 0.1 part of Radix Paeoniae Alba medicament extracting solution, 0.1 part of angelica extract, 0.1 part of crocus sativus, Hirudo japonica extract 0.3
Part, 0.1 part of Ginseng extract；
E phases：0.3 part of pentanediol, 0.3 part of vitamin E, 0.6 part of Phenoxyethanol.
Preferred embodiment two, on base case, the mass fraction of the raw material components is：A phases：3 parts of octadecyl alcolol, fourth
0.3 part of hydroxy toluene, 2 parts of isomery hexadecane, 1.5 parts of isopropyl myristate, 2.5 parts of glycerol stearate ester admixture, olive oil
0.2 part, 3.5 parts of caprylic/capric triglyceride；
B phases：60.5 parts of deionized water, 9 parts of glycerine；
C phases：1.5 parts of dimethyl silicone polymer, 1.8 parts of -13 mixture of polyacrylate；
D phases：12 parts of deionized water, 2 parts of glycine betaine, 2.5 parts of biological polyoses glue, 2.5 parts of niacinamide, aloe gel spraying are dry
0.4 part of powder, 0.2 part of Radix Paeoniae Alba medicament extracting solution, 0.2 part of angelica extract, 0.2 part of crocus sativus, Hirudo japonica extract 0.4
Part, 0.2 part of Ginseng extract；
E phases：0.4 part of pentanediol, 0.4 part of vitamin E, 0.5 part of Phenoxyethanol.
Preferred embodiment three, on base case, the mass fraction of the raw material components is：A phases：2 parts of octadecyl alcolol, fourth
0.2 part of hydroxy toluene, 0.8 part of isomery hexadecane, 1 part of isopropyl myristate, 3.5 parts of glycerol stearate ester admixture, olive oil
0.3 part, 2 parts of caprylic/capric triglyceride；
B phases：58 parts of deionized water, 6 parts of glycerine；
C phases：2.6 parts of dimethyl silicone polymer, 1.2 parts of -13 mixture of polyacrylate；
D phases：9 parts of deionized water, 1.5 parts of glycine betaine, 3 parts of biological polyoses glue, 2 parts of niacinamide, aloe gel spray dried powder
0.2 part, 0.1 part of Radix Paeoniae Alba medicament extracting solution, 0.3 part of angelica extract, 0.3 part of crocus sativus, Hirudo japonica extract 0.4
Part, 0.3 part of Ginseng extract；
E phases：0.3 part of pentanediol, 0.3 part of vitamin E, 0.6 part of Phenoxyethanol.
The present invention also provides another base case, the preparation method of the skin care moisturiser containing Hirudo japonica, operation steps
It is rapid as follows：
One) B phases, are taken：Deionized water, glycerine are heated to 70-90 DEG C, are stirred and opened with the rotating speed of 100-200rpm；
Two) A phases, are taken：Octadecyl alcolol, Butylated Hydroxytoluene, isomery hexadecane, isopropyl myristate, stearine mixing
Object, olive oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester are heated to 75-80 DEG C, and stirring is until dissolving；
Three) homogeneous, is opened, A is added in B phases, emulsifying temperature is 70-90 DEG C, with the rotating speed homogeneous 4- of 4000rpm
10min；
Four) after the completion of, emulsifying, stirring is cooled to 50 DEG C, is again turned on homogeneous, sequentially adds C phases：Polydimethylsiloxanes
Alkane, -13 mixture of polyacrylate, with the rotating speed homogeneous 3-6min of 4000rpm；
Five), continue stirring and be cooled to 40 degree；Prepare D phases：Deionized water, glycine betaine, biological polyoses glue, niacinamide, aloe
Gel powder spray dried powder, Radix Paeoniae Alba medicament extracting solution, angelica extract, crocus sativus, Hirudo japonica extract)：It is being cooled to
D phases are added at 40 DEG C, are stirred evenly；
Seven)：Finally sequentially add E phase raw materials：Pentanediol, vitamin E, Phenoxyethanol, stir evenly, and obtain finished product.
Preferred embodiment one, on second base case, the heating temperature of the step one) B phases is to 80 DEG C.
Preferred embodiment two, on second base case, the emulsifying temperature of the step three) homogeneous is 80 DEG C,
The time of matter is 5min.
Preferred embodiment three, on second base case, the time of the step four) homogeneous is 3min.
Specific embodiment
The component and mass fraction of each embodiment of skin care moisturiser of the present invention containing Hirudo japonica are as shown in table 1：
Table 1
Comparative example three：Commercially available moisturiser.
By taking embodiment two as an example, the preparation method of the present invention is illustrated, operating procedure is as follows：
One) B phases, are taken：Deionized water 60.5g, glycerine 9g are mixed and heated to 80 DEG C, are stirred with the rotating speed of 100-200rpm
It opens；
Two) A phases, are taken：Octadecyl alcolol 3g, Butylated Hydroxytoluene 0.3g, isomery hexadecane 2g, isopropyl myristate 1.5g, glycerine
Stearate mixture 2.5g, olive oil 0.2g, caprylic/capric triglyceride 3.5g are heated to 75-80 DEG C, and stirring is until molten
Solution, stearine the ingredients of a mixture are：Stearine, cetostearyl alcohol, stearoyl dilactic acid sodium, purchased from section
Nai Ou trades (Shanghai) Co., Ltd.；
Three) homogeneous, is opened, A is added in B phases, emulsifying temperature is 80 DEG C, with the rotating speed homogeneous 5min of 4000rpm；
Four) after the completion of, emulsifying, stirring is cooled to 50 DEG C, is again turned on homogeneous, sequentially adds C phases：Dimethyl silicone polymer
1.5g, -13 mixture 1.8g of polyacrylate, with the rotating speed homogeneous 3min of 4000rpm, -13 mixture of polyacrylate into
It is divided into：Polyacrylate -13, polyisobutene, polysorbate20 match BIC Corp purchased from France；
Five), continue stirring and be cooled to 40 degree；Prepare D phases：Deionized water 12g, glycine betaine 2g, biological polyoses glue 2.5g, cigarette
Amide 2.5g, aloe gel spray dried powder 0.4g, Radix Paeoniae Alba medicament extracting solution 0.2g, angelica extract 0.2g, crocus sativus
0.2g, Hirudo japonica extract 0.4g, Ginseng extract 0.2g；
Six)：D phases are added in when being cooled to 40 DEG C, are stirred evenly；
Seven)：Finally sequentially add E phase raw materials：Pentanediol 0.4g, vitamin E 0.4g, Phenoxyethanol 0.5g, stir evenly
, obtain finished product.
Embodiment one：
The operating method difference part of its operating method and embodiment two is：The heating temperature of step one) the B phases
To 85 DEG C, the emulsifying temperature of the step three) homogeneous is 85 DEG C, and the time of homogeneous is 8min, the step four) homogeneous
Time is 5min.
Embodiment three：
The operating method difference part of its operating method and embodiment two is：The heating temperature of step one) the B phases
To 70 DEG C, the emulsifying temperature of the step three) homogeneous is 70 DEG C, and time of homogeneous is 10min, the step four) homogeneous
Time be 6min.
Example IV：
The operating method difference part of its operating method and embodiment two is：The heating temperature of step one) the B phases
To 90 DEG C, the emulsifying temperature of the step three) homogeneous is 90 DEG C, and the time of homogeneous is 4min, the step four) homogeneous
Time is 3min.
Embodiment five：
The operating method difference part of its operating method and embodiment two is：The heating temperature of step one) the B phases
To 75 DEG C, the emulsifying temperature of the step three) homogeneous is 75 DEG C, and the time of homogeneous is 8min, the step four) homogeneous
Time is 4min.
Experiment finds that operating method has appearance, the sense of touch of product slightly difference, but the effect of product and preparation method
Difference is irrelevant.
Experiment one, moistening effect experiment
1. test environment conditions
20 DEG C -22 DEG C of environment temperature, humidity 40%-60%.
2. volunteer's condition
Age 80 people of volunteer (except pregnant or women breast-feeding their children) between 18-65 Sui is selected, is randomly divided into 8 groups, often
10 people of group.Volunteer without serious systemic disease, without immune deficiency or autoimmune disease, subject did not receive skin and controlled
Treat, beauty and other may influence the test of result, no active anaphylactia, no extremely sensitive person of constitution, nearly January
Inside not using hormone medicine and immunosuppressor, present or nearest three months recipient sites do not participate in other clinical tests
Person.
3. test method
Sample presses 3mg/cm2Dosage is uniformly applied on the inside of subject's left hand inner forearm (4cm*4cm) and right forearm
At (4cm*4cm), the hydrauture of skin is measured in 0.5h, 1h, 2h, 4h, the 8h for smearing sample respectively.Test result such as 2 institute of table
Show：
Table 2
By table 2 as it can be seen that in various embodiments of the present invention, the moistening effect of one~embodiment of embodiment five is with respect to comparative example
First, comparative example two, the effect of comparative example three are good, and the moistening effect of embodiment two is optimal, and comparative example one, the effect of comparative example two
It is poor, therefore, illustrate the compatible preferable moisturizer that can tell on of active ingredient in the D phases of the present invention, and without this
Active ingredient or the effect of only Hirudo japonica extract are poor.
Experiment two：Clinical test
1st, the healthy women of Chongqing region 240 is chosen as study subject, the range of age 18-60 Sui, average age 32
Year, without serious systemic disease, no immune deficiency or autoimmune disease, no skin allergic disease, in nearly one month not
Once using hormone medicine and immunosuppressor person, other clinical test persons are not participated in, tested material is used according to regulations and data is neat
Entirely, all volunteers should fill in informed consent form before test.Above-mentioned subject's facial skin is mainly shown as：Skin of face is done
Dry, nonelastic, peeling is coarse.It is divided into three test groups, every group 30, is carried out respectively using the sample in the embodiment of the present invention
Moistening effect is tested.
2nd, test method：This experiment uses Germany CK companies MPA9ZX21 type Multi-functional skin testers.Using makeup
1 day moisture for measuring its skin of face after 4 weeks with continuous use cosmetics before product, 22 DEG C ± 1 DEG C of test environment, humidity is
50% ± 5%, dry skin, cleaning are kept during test.
3rd, sample application method：After respectively being washed one's face respectively at early morning and just before going to bed with warm water, the subject of three test groups
The different samples of experimental example 1-3 of the present invention is taken uniformly to be applied to face respectively, then slight massaging 2-5 minutes, apply sample
Cloth is uniform, then retains 20 minutes or more on the face, then clean with warm water washing.All subjects are 3 days before this experiment
With experiment in the process without using other any cosmetics.
4th, moisture of skin increase rate=(continuous use cosmetics moisture after 4 weeks-use the moisture of 1 day before cosmetics
Content)/use the moisture * 100% of 1 day before cosmetics.Moisture increase rate is higher, illustrates that moistening effect is better.
5th, effect criterion：(1) it is effective：Skin moisturizing is smooth, skin effect phenomenon completely disappears, the colour of skin is ruddy flexible,
Moisture of skin increase rate is more than 10%；(2) effectively：Have dry skin, there is skin effect phenomenon but have improvement, the colour of skin take a turn for the better but elasticity not
Foot, moisture of skin increase rate is in 3%-10%；(3) it is invalid：Without improvement, moisture of skin increase rate exists for dry skin, skin effect phenomenon
Less than 3%.
6th, experimental result is as shown in table 3：
Table 3
| Invalid (ratio) | Effectively (ratio) | Effective (ratio) | |
| Embodiment one | Nothing | 14 (46.7%) | 16 (53.3%) |
| Embodiment two | Nothing | 4 (13.3%) | 26 (86.7%) |
| Embodiment three | Nothing | 12 (40%) | 18 (60%) |
| Example IV | Nothing | 6 (20%) | 24 (80%) |
| Embodiment five | Nothing | 8 (26.7%) | 22 (73.3%) |
| Comparative example one | 4 (13.3%) | 18 (60%) | 8 (26.7%) |
| Comparative example two | Nothing | 15 (50%) | 15 (50%) |
| Comparative example three | Nothing | 9 (30%) | 21 (70%) |
By table 3 as it can be seen that the moistening effect of one~embodiment of the embodiment of the present invention five is compared with comparative example one, two effect of comparative example
It is good, it is suitable with the effect of comparative example three, and the moistening effect of embodiment two is optimal, and the moistening effect of embodiment two is better than comparison
The moistening effect of example three.
For those skilled in the art, under the premise of not departing from the present invention, can also make it is several deformation and
It improves, these should also be considered as protection scope of the present invention, these all do not interfere with the reality of the effect implemented and patent of the invention
The property used.
Claims (8)
1. the skin care moisturiser containing Hirudo japonica, it is characterised in that：It is made of the raw material components of its following mass fraction,
A phases：1.5-3.5 parts of octadecyl alcolol, 0.2-0.4 parts of Butylated Hydroxytoluene, 0.5-2.5 parts of isomery hexadecane, isopropyl myristate
0.5-3 parts, 2-4 parts of glycerol stearate ester admixture, 0.1-0.4 parts of olive oil, 1-5 parts of caprylic/capric triglyceride；
B phases：55-65 parts of deionized water, 5-10 parts of glycerine；
C phases：1-4 parts of dimethyl silicone polymer, 0.8-2.5 parts of -13 mixture of polyacrylate；
D phases：5-15 parts of deionized water, 1-2.5 parts of glycine betaine, 1-4 parts of biological polyoses glue, 1-4 parts of niacinamide, aloe gel spraying
0.2-0.5 parts of dry powder, 0.05-0.3 parts of Radix Paeoniae Alba medicament extracting solution, 0.05-0.3 parts of angelica extract, crocus sativus 0.05-
0.3 part, 0.1-0.5 parts of Hirudo japonica extract, 0.05-0.3 parts of Ginseng extract；
E phases：0.2-0.5 parts of pentanediol, 0.2-0.5 parts of vitamin E, 0.5-0.8 parts of Phenoxyethanol；
Stearine the ingredients of a mixture is mainly stearine, cetostearyl alcohol, stearoyl dilactic acid sodium；
The main component of -13 mixture of polyacrylate is:Polyacrylate -13, polyisobutene and polysorbate -20.
2. the skin care moisturiser according to claim 1 containing Hirudo japonica, it is characterised in that：The raw material components
Mass fraction is：A phases：It is 2.5 parts of octadecyl alcolol, 0.3 part of Butylated Hydroxytoluene, 1.5 parts of isomery hexadecane, 1 part of isopropyl myristate, sweet
3 parts of oil-stearic acid ester admixture, 0.3 part of olive oil, 3 parts of caprylic/capric triglyceride；
B phases：59.1 parts of deionized water, 8 parts of glycerine；
C phases：2 parts of dimethyl silicone polymer, 1.6 parts of -13 mixture of polyacrylate；
D phases：10 parts of deionized water, 1.5 parts of glycine betaine, 2 parts of biological polyoses glue, 2 parts of niacinamide, aloe gel spray dried powder 0.3
Part, 0.1 part of Radix Paeoniae Alba medicament extracting solution, 0.1 part of angelica extract, 0.1 part of crocus sativus, 0.3 part of Hirudo japonica extract, people
Join 0.1 part of extracting solution；
E phases：0.3 part of pentanediol, 0.3 part of vitamin E, 0.6 part of Phenoxyethanol.
3. the skin care moisturiser according to claim 1 containing Hirudo japonica, it is characterised in that：The raw material components
Mass fraction is：A phases：3 parts of octadecyl alcolol, 0.3 part of Butylated Hydroxytoluene, 2 parts of isomery hexadecane, 1.5 parts of isopropyl myristate, glycerine
2.5 parts of stearate mixture, 0.2 part of olive oil, 3.5 parts of caprylic/capric triglyceride；
B phases：60.5 parts of deionized water, 9 parts of glycerine；
C phases：1.5 parts of dimethyl silicone polymer, 1.8 parts of -13 mixture of polyacrylate；
D phases：12 parts of deionized water, 2 parts of glycine betaine, 2.5 parts of biological polyoses glue, 2.5 parts of niacinamide, aloe gel spray dried powder
0.4 part, 0.2 part of Radix Paeoniae Alba medicament extracting solution, 0.2 part of angelica extract, 0.2 part of crocus sativus, Hirudo japonica extract 0.4
Part, 0.2 part of Ginseng extract；
E phases：0.4 part of pentanediol, 0.4 part of vitamin E, 0.5 part of Phenoxyethanol.
4. the skin care moisturiser according to claim 1 containing Hirudo japonica, it is characterised in that：The raw material components
Mass fraction is：A phases：2 parts of octadecyl alcolol, 0.2 part of Butylated Hydroxytoluene, 0.8 part of isomery hexadecane, 1 part of isopropyl myristate, glycerine
3.5 parts of stearate mixture, 0.3 part of olive oil, 2 parts of caprylic/capric triglyceride；
B phases：58 parts of deionized water, 6 parts of glycerine；
C phases：2.6 parts of dimethyl silicone polymer, 1.2 parts of -13 mixture of polyacrylate；
D phases：9 parts of deionized water, 1.5 parts of glycine betaine, 3 parts of biological polyoses glue, 2 parts of niacinamide, aloe gel spray dried powder 0.2
Part, 0.1 part of Radix Paeoniae Alba medicament extracting solution, 0.3 part of angelica extract, 0.3 part of crocus sativus, 0.4 part of Hirudo japonica extract, people
Join 0.3 part of extracting solution；
E phases：0.3 part of pentanediol, 0.3 part of vitamin E, 0.6 part of Phenoxyethanol.
5. the preparation method of the skin care moisturiser according to claims 1 to 4 containing Hirudo japonica, it is characterised in that：Behaviour
It is as follows to make step：
One) B phases, are taken：Deionized water, glycerine are heated to 70-90 DEG C, are stirred and opened with the rotating speed of 100-200rpm；
Two) A phases, are taken：Octadecyl alcolol, Butylated Hydroxytoluene, isomery hexadecane, isopropyl myristate, glycerol stearate ester admixture, olive
Olive oil, caprylic/capric triglyceride are heated to 75-80 DEG C, and stirring is until dissolving；
Three) homogeneous, is opened, A is added in B phases, emulsifying temperature is 70-90 DEG C, with the rotating speed homogeneous 4- of 4000rpm
10min；
Four) after the completion of, emulsifying, stirring is cooled to 50 DEG C, is again turned on homogeneous, sequentially adds C phases：Dimethyl silicone polymer gathers
- 13 mixture of acrylate, with the rotating speed homogeneous 3-6min of 4000rpm；
Five), continue stirring and be cooled to 40 degree；Prepare D phases：Deionized water, glycine betaine, biological polyoses glue, niacinamide, aloe gel
Powder spray dried powder, Radix Paeoniae Alba medicament extracting solution, angelica extract, crocus sativus, Hirudo japonica extract, Ginseng extract；
Six)：D phases are added in when being cooled to 40 DEG C, are stirred evenly；
Seven)：Finally sequentially add E phase raw materials：Pentanediol, vitamin E, Phenoxyethanol, stir evenly, and obtain finished product.
6. the preparation method of the skin care moisturiser according to claim 5 containing Hirudo japonica, it is characterised in that：Described
Step 1) B phases heating temperature to 80 DEG C.
7. the preparation method of the skin care moisturiser according to claim 5 containing Hirudo japonica, it is characterised in that：Described
Step 3) homogeneous emulsifying temperature for 80 DEG C, the time of homogeneous is 5min.
8. the preparation method of the skin care moisturiser according to claim 5 containing Hirudo japonica, it is characterised in that：Described
Step 4) homogeneous time be 3min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NL2030032A (en) * | 2021-12-03 | 2022-05-16 | Wolfberry Science Inst Ningxia Academy Of Agricultural And Forestry Sciences | Wolfberry capsule essence, preparation method and use thereof |
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| CN105641258A (en) * | 2016-04-20 | 2016-06-08 | 努尔尼沙·托乎提 | Preparation method of goat tail oil skin cream |
| CN109453059B (en) * | 2018-12-26 | 2022-03-11 | 广州市科能化妆品科研有限公司 | Whitening cosmetic additive, whitening sleep mask and preparation method of whitening cosmetic additive |
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| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN103263567A (en) * | 2013-05-24 | 2013-08-28 | 苏州谷力生物科技有限公司 | Acne-removing and face-cleaning composition and preparation method thereof |
| CN103622890A (en) * | 2013-11-19 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Ageing-resistant skin care composition containing leech extract |
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2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN103263567A (en) * | 2013-05-24 | 2013-08-28 | 苏州谷力生物科技有限公司 | Acne-removing and face-cleaning composition and preparation method thereof |
| CN103622890A (en) * | 2013-11-19 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Ageing-resistant skin care composition containing leech extract |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NL2030032A (en) * | 2021-12-03 | 2022-05-16 | Wolfberry Science Inst Ningxia Academy Of Agricultural And Forestry Sciences | Wolfberry capsule essence, preparation method and use thereof |
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