CN105641258A - A kind of preparation method of sheeptail oil skin ointment - Google Patents
A kind of preparation method of sheeptail oil skin ointment Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000002674 ointment Substances 0.000 title claims description 28
- 239000003921 oil Substances 0.000 claims abstract description 57
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- 238000002156 mixing Methods 0.000 claims abstract description 8
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- 235000015655 Crocus sativus Nutrition 0.000 abstract description 21
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- 239000000463 material Substances 0.000 description 2
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 2
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- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
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- 241001113425 Iridaceae Species 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
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- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
Description
技术领域technical field
本发明涉及一种皮肤膏的制备方法,特别是一种羊尾油皮肤膏的制备方法。The invention relates to a preparation method of skin ointment, in particular to a preparation method of sheeptail oil skin ointment.
背景技术Background technique
皮肤膏在中国古代人们的生活中有着广泛的使用。从自古代就有使用记载,多以动物油和植物油为基础,辅以多种药材制成,使用范围、功效广泛,主要有活血化瘀、美容、嫩肤等多种功效,不同的配方的效果都不相同,在中医、维医、蒙医里均有记载。Skin ointment was widely used in ancient Chinese people's life. It has been used since ancient times. It is mostly based on animal oil and vegetable oil, supplemented by a variety of medicinal materials. It has a wide range of uses and effects, mainly including promoting blood circulation, removing blood stasis, beautifying, and skin rejuvenation. The effects of different formulas They are all different, and are recorded in Chinese medicine, Uyghur medicine, and Mongolian medicine.
羊尾巴油,白色或微黄色蜡状固体,相对密度0.943~0.952。熔点42~48℃。碘值38~42。皂化值194-199。主要成分为油酸、硬脂酸和棕榈酸的甘油三酸酯。是从羊的尾巴附近和皮下含脂肪的组织,用熬煮法制取,油脂含量高,外用具有隔绝空气的效果。Sheep tail oil, white or light yellow waxy solid, relative density 0.943~0.952. The melting point is 42-48°C. The iodine value is 38-42. Saponification value 194-199. The main ingredients are triglycerides of oleic acid, stearic acid and palmitic acid. It is made from fat-containing tissue near the tail and subcutaneous of sheep by boiling. It has high oil content and has the effect of isolating air when used externally.
西红花,为鸢尾科植物番红花CrocussativusL的干燥柱头。引入栽培种。现北京、山东、浙江、四川等地有栽培。具有活血化瘀,凉血解毒,解郁安神的功效。用于经闭症瘕,产后瘀阻,温毒发斑,忧郁痞闷,惊悸发狂。Saffron is the dry stigma of Crocussativus L, a plant of the family Iridaceae. Introduce cultivars. It is now cultivated in Beijing, Shandong, Zhejiang, Sichuan and other places. There is blood circulation promoting and blood stasis dispelling, cooling blood and detoxification, effect of relieving stagnation and calming the nerves. For amenorrhea lumps in the abdomen, postpartum stasis, hot toxin hair spots, melancholy, ruffian, palpitation and madness.
中药皮肤膏以油脂为基础,辅以多种配方,有一定中药保健效果,适宜大范围生产销售。Traditional Chinese medicine skin ointment is based on oil and supplemented with various formulas. It has a certain health care effect of traditional Chinese medicine and is suitable for large-scale production and sales.
发明内容Contents of the invention
本发明的目的在于提供一种羊尾油皮肤膏的制备方法。The object of the present invention is to provide a kind of preparation method of sheeptail oil skin ointment.
一种羊尾油皮肤膏的制备方法,由下列组分按重量混合而成:羊尾油60-65份,西红花5-10份,羊骨髓8-12份,宰吉瓦油5-10份,橄榄油10-15份。A preparation method of sheeptail oil skin ointment, which is prepared by mixing the following components by weight: 60-65 parts of sheeptail oil, 5-10 parts of saffron, 8-12 parts of sheep bone marrow, 5- 10 parts, olive oil 10-15 parts.
进一步的,本发明的一种羊尾油皮肤膏的制备方法,由下述步骤组成:Further, the preparation method of a sheeptail oil skin ointment of the present invention consists of the following steps:
(1)熬制羊尾油:将羊尾部的油脂取下,放到加热容器中,温度维持在150-180℃,待羊尾的油脂出来后,把油渣滤除,将熬好的羊尾油放在干净的容器中;(1) Boiling sheep tail oil: remove the fat from the tail of the sheep, put it in a heating container, and keep the temperature at 150-180°C. Tail oil is placed in a clean container;
(2)西红花磨制:将西红花放到研磨机中研磨,将研磨的粉末放在0.3mm×0.3mm的筛网中,将大颗粒粉末去除,得到西红花粉末;(2) Grinding of saffron: putting saffron into a grinder for grinding, putting the ground powder in a sieve of 0.3mm×0.3mm, removing the large particle powder to obtain saffron powder;
(3)羊骨髓制膏:将羊骨髓放到搅拌器中,搅拌5-8分钟,制成膏状;(3) Goat bone marrow paste: put the goat bone marrow in a blender and stir for 5-8 minutes to make a paste;
(4)水浴混合:将羊尾油放到水浴器中,水浴温度控制在60-75℃,将西红花粉、羊骨髓膏、宰吉瓦油,橄榄油按比例放入到羊尾油中,均匀搅拌8-10分钟;(4) Water bath mixing: put the sheep tail oil in a water bath, and control the temperature of the water bath at 60-75°C, put the saffron powder, sheep bone marrow paste, Zajiwa oil, and olive oil into the sheep tail oil in proportion , stir evenly for 8-10 minutes;
(5)制膏:将上述混合液体分装在容器中,放置在28℃以下的室内,静置24小时以上,即可制成羊尾油皮肤膏。(5) Ointment preparation: the above mixed liquid is divided into containers, placed in a room below 28°C, and left to stand for more than 24 hours to make sheeptail oil skin ointment.
具体的,在本发明中:Specifically, in the present invention:
西红花,本品呈线形,三分枝,长约3cm。暗红色,上部较宽而略扁平,顶端边缘显不整齐的齿状,内侧有一短裂隙,下端有时残留一小段黄色花柱。体轻,质松软,无油润光泽,干燥后质脆易断。气特异,微有刺激性,味微苦。记载于《中华人民共和国药典》2010版第一部-120-121;Saffron, this product is linear, three-branched, about 3cm long. Dark red, the upper part is wider and slightly flattened, the edge of the top is irregularly toothed, there is a short crack inside, and a small section of yellow style sometimes remains at the lower end. Light in body, soft in quality, non-oily and lustrous, brittle and easy to break after drying. Specific gas, slightly irritating, slightly bitter taste. Recorded in the first part of "Pharmacopoeia of the People's Republic of China" 2010 edition -120-121;
本发明的羊尾油皮肤膏有较好的护肤和防晒效果,对烧伤也有一定疗效,同时,具有活血化瘀的作用。The sheeptail oil skin ointment of the invention has good skin care and sunscreen effects, and has certain curative effect on burns, and at the same time, has the effect of promoting blood circulation and removing blood stasis.
具体实施方式detailed description
为能详细说明本发明,下面结合具体实施例对本发明做进一步详细的描述。In order to illustrate the present invention in detail, the present invention will be further described in detail below in conjunction with specific examples.
实施例1Example 1
本发明中的羊尾油皮肤膏的制备方法实施例:The preparation method embodiment of sheep tail oil skin ointment among the present invention:
一种羊尾油皮肤膏的制备方法,由下述步骤组成:A preparation method of sheeptail oil skin ointment, comprising the following steps:
(1)熬制羊尾油:将1000g羊尾部的油脂取下,放到加热容器中,温度维持在150-180℃,待羊尾的油脂出来后,把油渣滤除,得到780g羊尾油,放在干净的容器中;(1) Boil sheep tail oil: remove 1000g of sheep tail fat, put it in a heating container, keep the temperature at 150-180°C, after the sheep tail fat comes out, filter out the oil residue, and get 780g sheep tail oil, in a clean container;
(2)西红花磨制:将120g西红花放到研磨机中研磨,将研磨的粉末放在0.3mm×0.3mm的筛网中,将大颗粒粉末去除,得到115g西红花粉末;(2) Grinding of saffron: put 120g saffron into a grinder for grinding, put the ground powder in a 0.3mm×0.3mm sieve, remove the large particle powder, and obtain 115g saffron powder;
(3)羊骨髓制膏:将100g羊骨髓放到搅拌器中,搅拌8分钟,制成膏状;(3) Oat bone marrow preparation: put 100g of sheep bone marrow in a blender, stir for 8 minutes, and make a paste;
(4)水浴混合:将600g羊尾油放到水浴器中,水浴温度控制在60-75℃,将100g西红花粉、100g羊骨髓膏、100g宰吉瓦油、100g橄榄油按比例放入到羊尾油中,均匀搅拌10分钟;(4) Mixing in a water bath: put 600g of sheep tail oil in a water bath, and control the temperature of the water bath at 60-75°C. Put 100g of saffron pollen, 100g of sheep bone marrow paste, 100g of Zajiva oil, and 100g of olive oil in proportion Add to sheeptail oil and stir evenly for 10 minutes;
(5)制膏:将上述混合液体分装在容器中,放置在28℃以下的室内,静置24小时,得到所述羊尾油皮肤膏。(5) Ointment preparation: the above-mentioned mixed liquid is divided into containers, placed in a room below 28° C., and left to stand for 24 hours to obtain the sheeptail oil skin ointment.
实施例2Example 2
本发明中的羊尾油皮肤膏的制备方法实施例:The preparation method embodiment of sheep tail oil skin ointment among the present invention:
一种羊尾油皮肤膏的制备方法,由下述步骤组成:A preparation method of sheeptail oil skin ointment, comprising the following steps:
(1)熬制羊尾油:将1000g羊尾部的油脂取下,放到加热容器中,温度维持在150-180℃,待羊尾的油脂出来后,把油渣滤除,得到760g羊尾油,放在干净的容器中;(1) Cook sheep tail oil: remove 1000g of sheep tail fat, put it in a heating container, keep the temperature at 150-180°C, after the sheep tail fat comes out, filter out the oil residue, and get 760g of sheep tail oil, in a clean container;
(2)西红花磨制:将100g西红花放到研磨机中研磨,将研磨的粉末放在0.3mm×0.3mm的筛网中,将大颗粒粉末去除,得到90g西红花粉末;(2) Grinding of saffron: put 100g of saffron into a grinder for grinding, put the ground powder in a 0.3mm×0.3mm sieve, remove the large particle powder, and obtain 90g of saffron powder;
(3)羊骨髓制膏:将150g羊骨髓放到搅拌器中,搅拌5分钟,制成膏状;(3) Oat bone marrow preparation: put 150g of sheep bone marrow in a blender, stir for 5 minutes, and make a paste;
(4)水浴混合:将600g羊尾油放到水浴器中,水浴温度控制在60-75℃,将80g西红花粉、120g羊骨髓膏、100g宰吉瓦油、100g橄榄油按比例放入到羊尾油中,均匀搅拌10分钟;(4) Mixing in a water bath: put 600g of sheep tail oil in a water bath, and control the temperature of the water bath at 60-75°C. Put 80g of saffron pollen, 120g of sheep bone marrow paste, 100g of zajiwa oil, and 100g of olive oil in proportion Add to sheeptail oil and stir evenly for 10 minutes;
(5)制膏:将上述混合液体分装在容器中,放置在28℃以下的室内,静置24小时,得到所述羊尾油皮肤膏。(5) Ointment preparation: the above-mentioned mixed liquid is divided into containers, placed in a room below 28° C., and left to stand for 24 hours to obtain the sheeptail oil skin ointment.
实施例3Example 3
本发明中的羊尾油皮肤膏的制备方法实施例:The preparation method embodiment of sheep tail oil skin ointment among the present invention:
一种羊尾油皮肤膏的制备方法,由下述步骤组成:A preparation method of sheeptail oil skin ointment, comprising the following steps:
(1)熬制羊尾油:将1000g羊尾部的油脂取下,放到加热容器中,温度维持在150-180℃,待羊尾的油脂出来后,把油渣滤除,得到780g羊尾油,放在干净的容器中;(1) Boil sheep tail oil: remove 1000g of sheep tail fat, put it in a heating container, keep the temperature at 150-180°C, after the sheep tail fat comes out, filter out the oil residue, and get 780g sheep tail oil, in a clean container;
(2)西红花磨制:将100g西红花放到研磨机中研磨,将研磨的粉末放在0.3mm×0.3mm的筛网中,将大颗粒粉末去除,得到93g西红花粉末;(2) Grinding of saffron: 100g of saffron is put into a grinder for grinding, the ground powder is placed in a 0.3mm×0.3mm sieve, and the large particle powder is removed to obtain 93g of saffron powder;
(3)羊骨髓制膏:将150g羊骨髓放到搅拌器中,搅拌5分钟,制成膏状;(3) Oat bone marrow preparation: put 150g of sheep bone marrow in a blender, stir for 5 minutes, and make a paste;
(4)水浴混合:将600g羊尾油放到水浴器中,水浴温度控制在60-75℃,将80g西红花粉、120g羊骨髓膏、80g宰吉瓦油、120g橄榄油按比例放入到羊尾油中,均匀搅拌8分钟;(4) Mixing in a water bath: put 600g of sheep tail oil in a water bath, control the temperature of the water bath at 60-75°C, put 80g of saffron pollen, 120g of sheep bone marrow paste, 80g of zajiwa oil, and 120g of olive oil in proportion Add to sheeptail oil and stir evenly for 8 minutes;
(5)制膏:将上述混合液体分装在容器中,放置在28℃以下的室内,静置24小时,得到所述羊尾油皮肤膏。(5) Ointment preparation: the above-mentioned mixed liquid is divided into containers, placed in a room below 28° C., and left to stand for 24 hours to obtain the sheeptail oil skin ointment.
测试例一、毒性测试:Test example 1. Toxicity test:
实验材料:实施例1中羊尾油皮肤膏;Experimental material: sheep tail oil skin ointment in embodiment 1;
根据《中药、天然药物免疫毒性研究技术指导原则》和《职业性急性化学物中毒性血液系统诊断标准》对小白鼠进行毒性试验,试验结果合格,具体结果见下文试验具体实施及结论。According to the "Technical Guidelines for Immunotoxicity Research of Traditional Chinese Medicines and Natural Medicines" and "Diagnostic Criteria for Occupational Acute Chemical Poisoning Hematological System", the toxicity test was carried out on mice, and the test results were qualified. For specific results, see the specific implementation and conclusion of the test below.
小鼠每日喂食10g,连续喂食28天,上述实验鼠饮食活动未见异常,每日对实验鼠进行抽血检测,血样正常,停药7天,无明显药物依赖作用。观察期内无死亡,LD50大于5000毫克/公斤,属于实际无毒。The mice were fed with 10g per day for 28 consecutive days. There was no abnormality in the dietary activities of the above-mentioned experimental mice. Blood samples were drawn from the experimental mice every day, and the blood samples were normal. The drug was withdrawn for 7 days, and there was no obvious drug dependence. There was no death during the observation period, and the LD50 was greater than 5000 mg/kg, which was actually non-toxic.
测试例二、眼刺激试验:Test example 2. Eye irritation test:
以实施例1中的羊尾油皮肤膏为例,对小鼠进行眼刺激试验,实验结果为急性眼刺激积分指数为0,说明对粘膜无刺激作用。Taking the ointment of sheep tail oil in Example 1 as an example, an eye irritation test was carried out on mice. The result of the experiment was that the acute eye irritation integral index was 0, indicating that it had no irritation to the mucous membrane.
通过上述用品安全实验的测试数据可以得知,本发明无急性毒副作用、药物依赖作用。It can be known from the test data of the above product safety experiment that the present invention has no acute toxic side effects and drug dependence.
以上显示和描述了本发明的基本原理和主要特征及本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的只是说明本发明的原理,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above-mentioned embodiments, and what described in the above-mentioned embodiments and the description only illustrates the principles of the present invention, and the present invention will also have other functions without departing from the spirit and scope of the present invention. Variations and improvements are possible, which fall within the scope of the claimed invention. The protection scope of the present invention is defined by the appended claims and their equivalents.
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CN109998098A (en) * | 2019-05-07 | 2019-07-12 | 买买提木沙·阿力比亚提 | A kind of Kirgiz formula external use health care product with special effect to restore body function and preparation method thereof |
CN113304095A (en) * | 2021-06-17 | 2021-08-27 | 内蒙古农业大学 | Pure natural sheep tail oil lipstick |
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CN103767897A (en) * | 2014-01-26 | 2014-05-07 | 新疆亲努尔生物科技有限公司 | Sheep tail oil cream for children and preparation method thereof |
CN105342966A (en) * | 2015-12-05 | 2016-02-24 | 重庆市中药研究院 | Skin care moisturizer containing hirudo nipponia and preparation method of skin care moisturizer |
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CN103767897A (en) * | 2014-01-26 | 2014-05-07 | 新疆亲努尔生物科技有限公司 | Sheep tail oil cream for children and preparation method thereof |
CN105342966A (en) * | 2015-12-05 | 2016-02-24 | 重庆市中药研究院 | Skin care moisturizer containing hirudo nipponia and preparation method of skin care moisturizer |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN109998098A (en) * | 2019-05-07 | 2019-07-12 | 买买提木沙·阿力比亚提 | A kind of Kirgiz formula external use health care product with special effect to restore body function and preparation method thereof |
CN113304095A (en) * | 2021-06-17 | 2021-08-27 | 内蒙古农业大学 | Pure natural sheep tail oil lipstick |
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