CN106361684A - Active composition for adjusting microorganism ecological balance of skin surface - Google Patents
Active composition for adjusting microorganism ecological balance of skin surface Download PDFInfo
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- CN106361684A CN106361684A CN201610781095.4A CN201610781095A CN106361684A CN 106361684 A CN106361684 A CN 106361684A CN 201610781095 A CN201610781095 A CN 201610781095A CN 106361684 A CN106361684 A CN 106361684A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses an active composition for adjusting microorganism ecological balance of a skin surface, and aims to provide an active composition capable of effectively promoting growth and reproduction of beneficial bacteria, inhibiting multiplication of harmful bacteria and adjusting microorganism ecological balance of the skin surface. The composition comprises, by weight, 3-15 parts of fructo-oligosaccharide, 5-12 parts of monosaccharide compositions, 1-8 parts of lactobacillus/soybean milk fermentation product filtrate and 30-50 parts of polyhydric alcohols. The invention belongs to the technical field of biology.
Description
Technical field
The present invention relates to a kind of compositionss, specifically, it is related to a kind of regulation skin surface microbial ecological balance
Active compound, belongs to biological technical field.
Background technology
It is engraved in during skin and come into contacts with the probiotic bacteria on its surface and harmful bacteria, coexistence and co-prosperity, influence each other.Probiotic bacteria and having
The dynamic equilibrium (i.e. microecological balance) of evil bacterium, has close relationship with ecological film.
Ecological film is the family of probiotic bacteria, and it is the one layer of very thin emulsified fatty substance film being formed in skin surface, by sebum, antiperspirant
Liquid, the cell die, the probiotic bacteria of a large amount of symbiosis and its metabolite (ferment) collectively constitute, and can prevent moisture evaporation, improve
Skin cell metabolism, self-cleaning, self preservation, the ability such as self-regeneration.
Skin microecosystem balance remains stablizing of skin environment, and good ambient condition can be conducive to probiotic bacteria
Growth, probiotic bacteria quantity is more than harmful bacteria, thus skin food (perspiration, sebum and dead bark) is sucked by probiotic bacteria, promotees further
Enter probiotic bacteria breeding, reach optimum circulation.But excessive cleaning, the external world chemically and physically factor for example antibiotic, ultraviolet,
Lack nutrition, cold, the balance that all can destroy between probiotic bacteria and harmful bacteria, invasion flora stress be waited.When probiotic bacteria quantity reduces,
They will gradually be replaced by harmful bacteria, and skin food is sucked by harmful bacteria, promote harmful bacteria to breed further again, lead to skin
Skin environment changes, and simultaneously also thus changing the environment of growth of probiotics, produces pernicious circulation.Skin is occupied meeting by pathogen
Cause infection and the stress such as inflammation, redness, prurituss, cicatrix, erythema, lose original brilliance, or even cause more skin to ask
Topic.
Mainly realized by prebioticses currently used for adjusting skin microecological balance, prebioticses are beneficial by selectively promoting
The growth and breeding of bacterium, is colonized by occupy-place, and competition nutrition and secretion inhibiting substances etc., to suppress the growth of harmful bacteria, make imbalance
Tiny ecosystem returns to the material of normal condition.Relatively common in prebioticses is oligosaccharide (i.e. oligosaccharide), and oligosaccharide is except permissible
As prebioticses, itself can also activate skin immune cells release immune factor, improve skin and resist extraneous antibacterial and disease
The ability of poison；And probiotic bacteria metabolite is then to make the Tiny ecosystem of imbalance return to normal shape by suppressing the growth of harmful bacteria
State.
With the rise of skin microbial, the research about adjusting the skin microecological balance mechanism of action is day by day ripe,
Adjusting and safeguard skin microecological balance from root thus improving skin quality, the new direction of industry development will be become.How as early as possible
Develop one kind to effectively facilitate probioticss growth and breeding and suppress harmful bacteria increment, realize adjusting the combination of skin microecological balance
Thing, is the technical barrier of those skilled in the art's urgent need to resolve.
Content of the invention
For the problems referred to above, it is an object of the invention to provide a kind of effectively facilitate the growth and breeding of probioticss and suppress harmful
The increment of bacterium, realizes adjusting the active compound of skin surface microbial ecological balance.
For solving above-mentioned technical problem, the technical scheme that the present invention provides is such that
A kind of active compound adjusting skin surface microbial ecological balance, including following components in parts by weight: oligomeric
Fructose 3-15 part, monosaccharide compositionss 5-12 part, lactobacilluss/bean milk tunning filtrate 1-8 part, polyhydric alcohol 30-50 part.
Further, a kind of active compound of above-mentioned regulation skin surface microbial ecological balance, also includes yeast
Bacterium tunning filtrate 1-6 part or fermentation of bacillus product 1-6 part or lactobacilluss/bear's weed tunning are extracted
Thing 1-6 part.
Further, a kind of above-mentioned regulation skin surface microbial ecological balance active compound it is characterised in that:
Also include sugar Thallus Laminariae (Thallus Eckloniae) extract 2-10 part and krameria triandra root extract 1-5 part.
Further, a kind of above-mentioned regulation skin surface microbial ecological balance active compound it is characterised in that:
Also include extra large sludge extract 1-6 part.
Further, a kind of above-mentioned regulation skin surface microbial ecological balance active compound it is characterised in that:
Described monosaccharide compositionss rhamnose for 7:5:3:2 by ratio, glucose, glucuronic acid, fucose forms.
Further, the active compound of above-mentioned a kind of regulation skin surface microbial ecological balance, becomes silted up in described sea
Mud extract passes through following step and is obtained:
1) take glacier sea mud, under conditions of room temperature, add distilled water stirring to make mud, after crossing 800 mesh sieves, with
8000r/min, is centrifuged 10min, collects wet mud, after 800 mesh sieves after dry, pulverize, obtains glacier sea mud dry powder；
2) taking step 1) glacier prepared sea mud dry powder is dissolved in distilled water, adjusts ph 6-7, extract at 35-50 DEG C
30min, agitated, after mixing, take clear liquor with after 10000r/min centrifugation 10min, precipitation plus suitable quantity of water repeat to process 3 times,
Merge 3 secondary clearing liquid and be settled to 250ml, decompression rotary evaporation, to 100ml, is obtained sea sludge extract；
The weight ratio of the glacier sea mud described in wherein: step 1) and distilled water is for 1:3；Step 2) described in glacier sea become silted up
The weight of mud dry powder and distilled water is than for 1:5.
Compared with prior art, the technical scheme that the present invention provides has the advantage that
(1) the monosaccharide compositionss that the present invention provides are by rhamnose, glucose, glucuronic acid and fucose compound and
Become, they are fine with the affinity of horn cell, by occupying horn cell receptor, can effectively suppress harmful bacteria to stick to skin
On skin surface, and suppress inflammatory factor il8 and the release of pge2.This monosaccharide compositions is compounded with oligofructose, can promote
Skin surface probioticss activity, suppresses harmful bacteria, recovers the ecological balance of skin surface microorganism, controls and is forming one-level play
The flaw increasing and acne, the malaise symptoms such as the inflammation of alleviation skin, prurituss, small pox.
(2) lactobacilluss/bean milk tunning filtrate that the present invention provides comprise the opposing of different lactic acid bacillus mycopremnas stress
Reaction and the cell debriss that produce are containing various active molecule such as aminoacid, protein, polypeptide, vitamin, phospholipid etc., and low
Polyfructose., monosaccharide compositionss and the mutual compatibility of polyhydric alcohol, have inhibitory action for various stimulus, skin can be helped to resist outer
To stimulate, and to have powerful moisturizing, releive and repair effect.
(3) technical scheme that the present invention provides contains yeast fermentation Product filtrate, fermentation of bacillus product, lactic acid bar
Any one in bacterium/bear's weed tunning extract.Wherein, yeast fermentation Product filtrate contains various active
Point, skin can be risen with moisturizing, promote cellular metabolism, whitening etc. acts on, and helps improve skin, improves skin allergy；Bud
Spore bacillus fermentation product is a kind of cutin lysozyme；Lactobacilluss/bear's weed tunning extract be selected from California and
The bear's weed of northern Mexico and lactobacillus fermentation form, and (have non-rich in mucopolysaccharide (polysaccharide of highly branched chain) and glycoprotein
Often good hydratability), the glucoprotein structure of similar human skin, there is good moisturizing, lubricate and releive performance, promote to support
Divide and absorb, improve polysaccharides and glucoprotein astringent sense, increase skin softness and smoothness.
(4) sugar Thallus Laminariae (Thallus Eckloniae) extract and krameria triandra root extract are compounded by the technical scheme that the present invention provides, can
To suppress harmful bacteria breeding.Wherein, sugar Thallus Laminariae (Thallus Eckloniae) extract is skin purification factor, rich in brown algae polyphenols, has cleaning and sterilization work(
Can, can help remove the microorganism of invasion, the oils and fatss of excessive secretion can be reduced, adjust physiological equilibrium simultaneously；The present invention provides
Krameria triandra root extract contains neolignan constituents, has antifungal, antiinflammatory, antioxidation and antimicrobial acivity (spy
Other to gram positive bacteria).
(5) the extra large sludge extract that the present invention provides is selected from glacier sea mud, and the granule of this mud is fine and smooth, rich in abundant
Mineral and ocean elite, simultaneously for faintly acid and have potassium/na ratio in a balanced way, can effectively maintain the ph of skin balance
Value, maintains the greasy dirt in the isobaric environment of skin cell, and abundant unclogging so that nutrient is effectively sent to pore bottom,
It is more beneficial for skin absorption.
Sum it up, the technical scheme that the present invention provides can effectively facilitate probioticss growth and breeding, and suppress harmful bacteria
Increment, is conducive to maintaining the harmony with host's (skin) for the micropopulation of skin surface, the composition to biological barrier, sebaceous gland
Decomposition, acid cover formed and its important effect.It is particularly advantageous in dominant population Propionibacterium in skin microecosystem
With permanent bacterium such as staphylococcus epidermidiss, cover beneficial to collaborative decomposition skin lipid material, acid；Furthermore, it is possible to promote propionibacterium, bar-shaped
Bacillus decomposes Keratoderma layer residue, secretes regulator class material, stimulates the growth such as staphylococcus epidermidiss.
And, above component synergism, safeguards the microecological balance of skin jointly, recover and strengthen skin itself self
Update the ability with maintenance, skin quality is improved from root, solve drying, sallow well, coarse, the skin subhealth state such as sensitivity is asked
Topic.
Specific embodiment
With reference to specific embodiment, the claim of the present invention is described in further detail, but do not constitute right
Any restriction of the present invention, the modification of anyone limited number of time being made in the claims in the present invention protection domain etc, still exist
Within the claims of the present invention.
It should be noted that the raw material employed in the technical scheme of present invention offer, outside non-specified otherwise, all by often
Rule means are prepared or are bought by commercial channel.
Yeast fermentation Product filtrate is purchased in Angel Yeast Co., Ltd；Fermentation of bacillus product is purchased in section
Nai Ou trade (Shanghai) Co., Ltd.；Lactobacilluss/bear's weed tunning extract is purchased in the right biotechnology of Guangzhou promise
Company limited；Sugar Thallus Laminariae (Thallus Eckloniae) extract is purchased in Guangzhou hundred Hao Bo company limited；Krameria triandra root extract is purchased in Shenzhen
Rui Jite bio tech ltd；Rhamnose, glucose, glucuronic acid, lactobacilluss/bean milk tunning filtrate purchase in
Guangzhou Ou Jin Chemical Co., Ltd.；Fucose is purchased in Hebei Yuan Chuan bio tech ltd.
Embodiment 1
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 3g, monosaccharide compositionss 12g, lactobacilluss/bean milk tunning filtrate 1g, butanediol 20g, 1,2- penta
Glycol 10g, 1,2- hexanediol 20g.
Embodiment 2
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 15g, monosaccharide compositionss 5g, lactobacilluss/bean milk tunning filtrate 8g, 1,2- hexanediol 15g, 1,
Ammediol 15g.
Embodiment 3
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 10g, monosaccharide compositionss 7g, lactobacilluss/bean milk tunning filtrate 5g, butanediol 8g, 1,2- penta 2
Alcohol 8g, 1,2- hexanediol 8g, 1,3-PD 8g, yeast tunning extract 4g.
Embodiment 4
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 12g, monosaccharide compositionss 8g, lactobacilluss/bean milk tunning filtrate 6g, butanediol 15g, 1,2- penta
Glycol 20g, fermentation of bacillus product 4g.
Embodiment 5
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 11g, monosaccharide compositionss 11g, lactobacilluss/bean milk tunning filtrate 7g, butanediol 38g, lactic acid bar
Bacterium/bear's weed tunning extract 5g.
Embodiment 6
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into:
Oligofructose 4g, monosaccharide compositionss 6g, lactobacilluss/bean milk tunning filtrate 2g, 1,3-PD 35g, sugar
Thallus Laminariae (Thallus Eckloniae) extract 10g and krameria triandra root extract 2g.
Embodiment 7
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 5g, monosaccharide compositionss 7g, lactobacilluss/bean milk tunning filtrate 3g, butanediol 15g, 1,2- penta 2
Alcohol 15g, 1,3-PD 8g, extra large sludge extract 6g.
Embodiment 8
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 6g, monosaccharide compositionss 8g, lactobacilluss/bean milk tunning filtrate 4g, butanediol 30g, 1,3- the third two
Alcohol 9g, yeast tunning extract 6g, sugar Thallus Laminariae (Thallus Eckloniae) extract 3g and krameria triandra root extract 5g.
Embodiment 9
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
Be grouped into: oligofructose 7g, monosaccharide compositionss 9g, lactobacilluss/bean milk tunning filtrate 5g, butanediol 12g, 1,2- oneself two
Alcohol 16g, 1,3-PD 12g, fermentation of bacillus product 5g, sugar Thallus Laminariae (Thallus Eckloniae) extract 4g and krameria triandra root extract 4g.
Embodiment 10
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 8g, monosaccharide compositionss 10g, lactobacilluss/bean milk tunning filtrate 7g, butanediol 12g, 1,2- is own
Glycol 12g, 1,3-PD 12g, lactobacilluss/bear's weed tunning extract 6g, sugar Thallus Laminariae (Thallus Eckloniae) extract 4g and Peru
Ratanhia extract 4g.
Embodiment 11
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 11g, monosaccharide compositionss 10g, lactobacilluss/bean milk tunning filtrate 6g, 1,3-PD 46g, ferment
Female tunning extract 3g, extra large sludge extract 1g.
Embodiment 12
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 13g, monosaccharide compositionss 10g, yeast tunning extract 6g, butanediol 20g, 1,3-PD
23g, fermentation of bacillus product 5g, extra large sludge extract 3g.
Embodiment 13
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 15g, monosaccharide compositionss 7g, lactobacilluss/bean milk tunning filtrate 5g, butanediol 12g, 1,2- penta
Glycol 12g, 1,2- hexanediol 12g, 1,3-PD 12g, lactobacilluss/bear's weed tunning extract 5g, extra large mud
Extract 3g.
Embodiment 14
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 10g, monosaccharide compositionss 10g, lactobacilluss/bean milk tunning filtrate 6g, 1,2- hexanediol 45g, ferment
Female tunning extract 1g, sugar Thallus Laminariae (Thallus Eckloniae) extract 7g, krameria triandra root extract 4g and extra large sludge extract 3g.
Embodiment 15
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 11g, monosaccharide compositionss 10g, lactobacilluss/bean milk tunning filtrate 7g, 1,2- pentanediol 30g, bud
Spore bacillus fermentation product 5g, sugar Thallus Laminariae (Thallus Eckloniae) extract 8g, krameria triandra root extract 2g and extra large sludge extract 4g.
Embodiment 16
A kind of active compound of regulation skin surface microbial ecological balance that the present invention provides, by following weight array
It is grouped into: oligofructose 11, monosaccharide compositionss 7g, lactobacilluss/bean milk tunning filtrate 7g, butanediol 40g, lactic acid bar
Bacterium/bear's weed tunning extract 5g, sugar Thallus Laminariae (Thallus Eckloniae) extract 8g, krameria triandra root extract 2g and extra large sludge extract
3g.
Wherein, the monosaccharide compositionss of above-described embodiment 1-16 are by the rhamnose for 7:5:3:2 for the ratio, glucose, glucose
Aldehydic acid, fucose composition；Described yeast tunning extract can for yeast/soybean protein tunning or
Yeast/Fructus Hordei Vulgaris seed tunning filtrate, yeast/rice fermentation Product filtrate；Described fermentation of bacillus product can be
Bacillus cereuss/fermented soybean product extract, bacillus cereuss/rice bran extract/soybean extract tunning filtrate.
In above-described embodiment, the preparation method of extra large sludge extract is as follows:
1) take glacier sea mud, under conditions of room temperature, add distilled water stirring to make mud, after crossing 800 mesh sieves, with
8000r/min, is centrifuged 10min, collects wet mud, after 800 mesh sieves after dry, pulverize, obtains extra large mud dry powder；
2) taking step 1) the extra large mud dry powder prepared is dissolved in distilled water, adjusts ph6-7, extract at 35-50 DEG C
30min, agitated, after mixing, take clear liquor with after 10000r/min centrifugation 10min, precipitation plus suitable quantity of water repeat to process 3 times,
Merge 3 secondary clearing liquid and be settled to 250ml, decompression rotary evaporation, to 100ml, is obtained sea sludge extract；
The weight ratio of the glacier sea mud described in wherein: step 1) and distilled water is for 1:3；Step 2) described in extra large mud do
The weight of powder and distilled water is than for 1:5.
When specifically used, the active compound of section skin surface microbial ecological balance prepared by the present invention is dissolved in after water
It is directly appended in skin care item substrate, stirs, its addition accounts for the 0.5-6% of skin care item gross mass；Can also be by
Compositionss directly smear use after being made into aqueous solution.
The regulation skin surface microbial ecological of present invention offer, in order to better illustrate advantages of the present invention, is provided
The efficacy test of the active compound of balance:
(1) microbiological test
1st, the compositionss of embodiment of the present invention 1-16 are prepared solution as follows: first by oligofructose, monosaccharide group
Compound stirring is completely dissolved in deionized water, adds remaining material component and stirs.
2nd, respectively staphylococcus epidermidiss are inoculated in nutrient broth medium, bifidobacterium adolescentiss are inoculated in the training of tpy agar
Foster base, in nutrient broth medium, propionibacterium acness are inoculated in gam culture fluid to S. aureus Inoculate.Every kind of culture
Liquid respectively takes 10ml, each 4 parts, is separately added into compositionss and the 0.1ml deionized water (blank) of 0.1ml embodiment 1-16.So
Afterwards staphylococcus epidermidiss, bifidobacterium adolescentiss, staphylococcus aureuses are placed in the aerobic culture of 24h at 37 DEG C, by acne propanoic acid
Bacillus is placed in 48h Anaerobic culturel at 37 DEG C.Measure skin microbial in culture fluid before and after cultivating with dilution-plate method and count and compare
(cfu/ml).Measurement result is shown in Table 1.
Before and after table 1 culture, skin microbial counts and compares (cfu/ml)
Result shows, the compositionss of embodiment 1-16 can effectively facilitate skin normal bacterium (staphylococcus epidermidiss and youth
Bacillus bifiduss) propagation, inhibited to skin harmful bacteria (staphylococcus aureuses and propionibacterium acness), this is described
Bright compositionss can effectively adjust skin surface microbial ecological balance.
(2) human body in-service evaluation test
First, the compositionss in embodiment 1-16 are added separately in essence substrate, stir, make elite
Liquid, is calculated as essence 1-16 successively.Wherein: the mass ratio 4:96 of compositionss and essence substrate, the preparation side of essence substrate
Method is carried out according to this area common process and raw material.
1st, test population: vigorous from face skin fat secretion, there is an acne, red swelling of the skin, personnel 180 people of prurituss,
Age 18-28 year, sex is random, is divided into 18 groups, every group of 10 people.
2nd, test sample: essence 1-16 and any two oil control and acne removal essences commercially available.
3rd, method of testing:
Before experimenter smears sample, first voluntarily face cleaning, after drying, then smear sample in face, sooner or later respectively smear 1 time within 1 day,
Experimenter can not use other any cosmetics or other drugs during testing, and keeps light diet.Using right after 60 days
Experimenter is tested, statistical result.
In crowd using essence 1-16,88% people represents that skin oil and fat secretion significantly reduces, and acne fades away,
Red swelling of the skin and pruritis substantially mitigate；12% people represents that skin gradually tends to water and oil balance, and fat secretion reduces, acne
Improved, red swelling of the skin and pruritis mitigate；100% use people's group representation uses essence 1-16, and face is showed no
The side effect such as xerosis cutiss, sensation of pricking, inflammation, after 60 days, skin gradually becomes softness, water moistens and smooth.
In crowd using any two oil control and acne removal essences commercially available, only 52% people represents that skin oil and fat secretion has subtracted
Few, acne reduces, and red swelling of the skin and pruritis mitigate；The people having 40% represents that symptom has no improvement；The people having 8% represents oil
Fat secretion increases, and acne increases, red swelling of the skin and pruritis increase.
Result shows, the compositionss of embodiment 1-16 can effectively reduce the oils and fatss of excessive secretion, reduces acne, alleviates flesh
The malaise symptoms such as skin inflammation, prurituss, small pox.
In sum, the active compound of a kind of regulation skin surface microbial ecological balance that the present invention provides, each group
Divide synergism, jointly safeguard the microecological balance of skin, recover and strengthen the ability of skin itself self renewal and maintenance, from
Skin quality is improved on root, solves drying, sallow, coarse, the skin inferior health problem such as sensitivity well, skin can be made simultaneously to become
Soft, water profit and smooth.
Claims (6)
1. a kind of active compound adjusting skin surface microbial ecological balance is it is characterised in that include following weight parts
Component: oligofructose 3-15 part, monosaccharide compositionss 5-12 part, lactobacilluss/bean milk tunning filtrate 1-8 part, polyhydric alcohol 30-
50 parts.
2. a kind of active compound adjusting skin surface microbial ecological balance according to claim 1, its feature exists
In also including yeast fermentation Product filtrate 1-6 part or fermentation of bacillus product 1-6 part or lactobacilluss/North America holy
Careless tunning extract 1-6 part.
3. a kind of active compound adjusting skin surface microbial ecological balance according to claim 1, its feature exists
In also including sugar Thallus Laminariae (Thallus Eckloniae) extract 2-10 part and krameria triandra root extract 1-5 part.
4. a kind of active compound adjusting skin surface microbial ecological balance according to claim 1, its feature exists
In also including extra large sludge extract 1-6 part.
5. a kind of active compound adjusting skin surface microbial ecological balance according to claim 1, its feature exists
It is made up of the rhamnose for 7:5:3:2 for the ratio, glucose, glucuronic acid and fucose in, described monosaccharide compositionss.
6. a kind of active compound adjusting skin surface microbial ecological balance according to claim 4, its feature exists
In described extra large sludge extract passes through following step and is obtained:
1) take glacier sea mud, under conditions of room temperature, add distilled water stirring to make mud, after crossing 800 mesh sieves, with 8000r/
Min, is centrifuged 10min, collects wet mud, after 800 mesh sieves after dry, pulverize, obtains glacier sea mud dry powder；
2) taking step 1) glacier prepared sea mud dry powder is dissolved in distilled water, adjusts ph6-7, extract at 35-50 DEG C
30min, agitated, after mixing, take clear liquor with after 10000r/min centrifugation 10min, precipitation plus suitable quantity of water repeat to process 3 times,
Merge 3 secondary clearing liquid and be settled to 250ml, decompression rotary evaporation, to 100ml, is obtained sea sludge extract；
The weight ratio of the glacier sea mud described in wherein: step 1) and distilled water is for 1:3；Step 2) described in glacier sea mud do
The weight of powder and distilled water is than for 1:5.
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