CN112826790B - Pet shower gel capable of improving skin micro-ecology and preparation method thereof - Google Patents
Pet shower gel capable of improving skin micro-ecology and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention relates to a pet shower gel for improving skin micro-ecology and a preparation method thereof, wherein the preparation raw materials of the pet shower gel comprise the following components: probiotic fermented extract, ecological nutrient, surfactant, chelating agent, humectant, thickener, pH regulator, antiseptic and water. The shower gel for pets, disclosed by the invention, creatively combines the probiotic fermentation extract, the ecological nutrients and other conventional additive components, so that the shower gel has excellent effects of improving the micro-ecological balance of skin and repairing skin barriers, and is remarkable in moisturizing effect, safe and non-irritant.
Description
Technical Field
The invention belongs to the technical field of daily chemical articles for pets, particularly relates to a shower gel for pets and a preparation method thereof, and particularly relates to a shower gel for pets for improving skin micro-ecology and a preparation method thereof.
Background
The skin of pets protects the body against the external environment, and with the development and improvement of the technology, the layered research on the skin is more and more intensive, and in the daily care of the skin of pets, in addition to the skin physical barrier which is in contact with the skin, the skin microbial barrier is inseparable with the skin health of the pets. There are often some microorganisms present on the skin, some of which may be parasitic on the skin of pets for a longer period of time as a result of long-term adaptation, known as the normal skin microflora, also known as the normal skin flora. The normal flora and the host macroorganisms and the external environment form a habitat, microorganisms in the habitat colonize certain organs of the macroorganisms to form microbial localization, and the skin is also one of the localizations. This interdependence constitutes an ecosystem.
It is essential for the skin to possess a "good flora" which is a good condition of the skin, and skin health is largely dependent on the species of microorganisms present on the skin surface and how they interact. Most microorganisms are harmless to the skin, and a certain amount of microorganisms attached to the epidermis may even prevent the invasion of pathogenic bacteria. In general, the microbiome can be divided into several broad categories: the gastrointestinal tract, respiratory tract, genital mucosa and the skin. The microbiome is responsible for the normal functioning of the human organ functions including digestion, production of nutrients and activation of the immune system, the last of which is important to the skin. Not a single microorganism is responsible for this function, but a combination of bacterial, fungal and viral bacteria. As the pet grows, more and more microbes from the surrounding environment adhere to the skin, and over time, the skin microbiome matures, changes in the skin flora where the sebaceous glands are active, and the skin microbiome may become unbalanced.
At present, pets are generally bred, and care products of the pets, such as shower gel in the aspect of cleaning, pay more and more attention to the quality of the products.
CN111773164A discloses a bath lotion for pet, which is prepared from radix Sophorae Flavescentis, cortex Meliae root, herba Macleayae Cordatae, radix Angelicae Dahuricae, radix Stemonae, realgar, radix et caulis Opuntiae Dillenii, polygonum tinctorium, cortex Phellodendri, radix et rhizoma Rhei, and herba Rosmarini officinalis as medicinal materials; the prepared shower gel has strong detergency, is easy to clean and wash, has no stimulation to skin, and the cleaned skin hair is smooth, tender, cool, comfortable, rich in elasticity and delicate fragrance, has the effects of relieving itching, diminishing inflammation and promoting the renewal of skin cutin, is particularly remarkable in cleaning, nursing and health care of the skin, can remarkably reduce the colony number on the surface of the skin, and has a good degerming effect.
CN109833239A discloses a multifunctional pet bath lotion and a preparation method thereof. The multifunctional pet shower gel is prepared from the following raw materials in parts by mass: 5-20 parts of gleditsia sinensis lam stock solution, 2-4 parts of glycerol, 70-85 parts of rose hydrosol, 1-2 parts of radix angelicae, 2-3 parts of sweet almond oil and 10-15 parts of PHMB. The pet fur cleanser can clean pet furs, moisten skins, enable the furs to be full of gloss, smooth and easy to comb, remove body odor of the pet furs and inhibit breeding of bacteria.
However, most of the body wash for pets disclosed in the prior art focuses on the efficacy of removing mites and inhibiting bacteria, realgar and PHMB have strong irritation to the skin of pets, and are easy to cause sensitivity and irritation of pets, and the body wash for pets disclosed in the prior art does not consider the skin condition and the microbial population condition of pets, so that the body wash for pets for improving skin microecology is developed to promote the balance of skin microecology of pets, resist external irritation and protect physical and mental health of pets, and is very significant.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the shower gel for the pet and the preparation method thereof, and particularly relates to the shower gel for the pet for improving skin microecology and the preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a shower gel for pets, which can improve skin micro-ecology, and the preparation raw materials of the shower gel for pets comprise the following components: probiotic fermentation extract, ecological nutrient, surfactant, chelating agent, humectant, thickener, pH regulator, antiseptic and water.
The bath cream for pets creatively combines the probiotic fermented extract, the ecological nutrient and other conventional additive components including a surfactant, a chelating agent, a humectant, a thickening agent, a pH regulator, a preservative and water, so that the bath cream has excellent effects of improving the skin micro-ecological balance and repairing the skin barrier, has an obvious moisturizing effect, and is safe and non-irritant. The various components in the body wash for pets of the invention act respectively, and have synergistic effect on the beneficial effects, which is difficult to predict.
Preferably, the preparation raw materials of the shower gel for pets comprise the following components in parts by weight: 0-5 parts of probiotic fermented extract but not 0 part, 0-10 parts of ecological nutrient but not 0 part, 10-40 parts of surfactant, 0.05-0.2 part of chelating agent, 0.5-5 parts of humectant, 0.1-2 parts of thickening agent, 0.01-0.2 part of pH regulator, 0.1-1 part of preservative and 40-90 parts of water.
When the raw materials for preparing the shower gel for the pet are matched according to the specific mass ratio, the shower gel for the pet has more remarkable effects on the aspects of improving the micro-ecological balance of skin, repairing skin barriers, moisturizing effect and biological safety.
The probiotic fermented extract can be 0.1 part, 0.2 part, 0.4 part, 0.7 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 5 parts and the like in parts by weight.
The ecological nutrient can be 0.1 part, 0.5 part, 0.8 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 10 parts and the like in parts by weight.
The weight parts of the surfactant can be 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts and the like.
The chelating agent can be 0.05 part, 0.08 part, 0.1 part, 0.12 part, 0.15 part, 0.18 part, 0.2 part and the like in parts by weight.
The humectant can be 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like by weight.
The weight portion of the thickening agent can be 0.1 portion, 0.2 portion, 0.4 portion, 0.7 portion, 1 portion, 1.5 portions, 2 portions and the like.
The weight parts of the pH regulator can be 0.01 part, 0.02 part, 0.04 part, 0.07 part, 0.1 part, 0.15 part, 0.2 part and the like.
The preservative can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like in parts by weight.
The water may be present in an amount of 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, etc.
Other specific values within the above ranges can be selected, and are not described in detail herein.
In the present invention, the probiotic fermentation extract comprises any one of or a combination of at least two of lactobacillus fermentation lysate, yeast bifidus fermentation filtrate, or lactobacillus fermentation product. The combination of at least two of the above-mentioned two types, for example, the combination of lactobacillus fermentation lysate and bifidus yeast fermentation product filtrate, the combination of bifidus yeast fermentation product filtrate and lactobacillus fermentation product, the combination of lactobacillus fermentation lysate, bifidus yeast fermentation product filtrate and lactobacillus fermentation product, and the like, can be selected from any other combination modes, and are not described in detail herein.
The lactobacillus fermentation lysate contains polypeptide compounds with bacteriostatic action such as lactobacillin, is a natural bacteriostatic agent, has sedative and bactericidal effects on the skin, is adhered to epidermal cells, forms a protective barrier on the skin and protects the skin from being attacked by the external environment; contains components beneficial to skin care such as amino acid, small peptide, polysaccharide, B vitamins and the like, can strengthen the metabolism of stratum corneum, remove cell free radicals, inhibit the peroxidation of lipid, activate the repair performance of organisms, inhibit the activity of cell tyrosinase, and has the functions of repair, whitening and antioxidation; the lactobacillus fermentation lysate can also restore the balance of the proportion of various media, is beneficial to the regulation and control of an immune system and relieves the skin inflammation; the Natural Moisturizing Factor (NMF) is rich in lactic acid and sodium lactate, is a main water-soluble acid in the Natural Moisturizing Factor (NMF) of a human body, has strong hygroscopicity, effectively enhances the hydration of the horny layer, and prevents the water loss of the skin.
The lysate of the yeast fermentation product of the second split has strong immunity restoration resistance, can effectively protect the skin, is not damaged by ultraviolet rays, and helps to prevent the photoaging of the epidermis and the dermis. It produces small molecules including vitamin B group, minerals, amino acids, etc. that are beneficial for skin care; it can enhance stratum corneum metabolism, capture free radicals, inhibit lipid peroxidation, and has skin whitening and antiaging effects; the product is rich in nutrients, and has skin nourishing effect.
The lactobacillus is a lactic acid bacterium with wide distribution, is named because the fermentation sugar produces a large amount of lactic acid, contains peptidoglycan, teichoic acid, protein, phospholipid, sterol, fatty acid, various enzymes, peptide, amino acid, nucleotide, extracellular polysaccharide and the like, provides rich nutrition for skin, and has good anti-aging effect.
The probiotic fermented extract is preferably a combination of a lactobacillus fermented lysate, a secondary split yeast fermented product filtrate and a lactobacillus fermented product, has more excellent performances in the aspects of improving the microecological balance of pet skin and repairing the skin barrier of a pet under the condition of meeting a specific mass ratio relationship, has more obvious synergistic effect with ecological nutrients, and has a certain auxiliary moisturizing effect.
Preferably a combination of a lactobacillus fermentation lysate, a secondary split yeast fermentation filtrate and a lactobacillus fermentation product.
Preferably, the mass ratio of the lactobacillus fermentation lysate, the secondary fission yeast fermentation product filtrate to the lactobacillus fermentation product is (1-2): 1, such as 1.
In the present invention, the ecological nutrient includes any one or a combination of at least two of inulin, alpha-glucan oligosaccharide, fructooligosaccharide, galactooligosaccharide, xylooligosaccharide, isomaltooligosaccharide, or soybean oligosaccharide; the combination of at least two of the inulin and the alpha-glucan oligosaccharide, the alpha-glucan oligosaccharide and the fructo-oligosaccharide, the galacto-oligosaccharide and the xylo-oligosaccharide, and the like can be selected in any combination manner, and the details are not repeated herein.
The ecological nutrient can stimulate the growth of beneficial flora, does not stimulate the growth of harmful bacteria with potential pathogenicity or putrefactive activity, has 'external supplement and internal regulation' by cooperating with the components of the probiotic fermented extract in the shower gel, enables the probiotic microbiota of the pet to play a greater role, and has the optimal effect by combining inulin, alpha-glucan oligosaccharide, galacto-oligosaccharide and soybean oligosaccharide. The combination mode can assist in stabilizing the foam of the shower gel, has good dispersibility, spreadability and thickening effect, can make the foam fine and soft, is easy to wash and clean, has good skin feel, can smooth the skin of a pet and maintain hair, and has certain anti-oxygen property and nutrition effect.
A combination of inulin, alpha-glucan oligosaccharides, galactooligosaccharides and soy oligosaccharides is preferred.
Preferably, the mass ratio of the inulin, the alpha-glucan oligosaccharide, the galactooligosaccharide and the soybean oligosaccharide is (2-3): 1-2, such as 2.
When the mass ratio of the inulin to the alpha-glucan oligosaccharide to the galactooligosaccharide to the soybean oligosaccharide satisfies the mass ratio relationship, the inulin has a more remarkable effect on stimulating the growth of beneficial flora.
In the present invention, the surfactant includes any one of sodium laureth sulfate, cocamide DEA, cocamide propyl betaine, or lauryl glucoside, or a combination of at least two thereof; the combination of at least two of the above-mentioned compounds, such as the combination of sodium laureth sulfate and cocamide DEA, the combination of cocamide propyl betaine and lauryl glucoside, the combination of cocamide DEA and cocamide propyl betaine, etc., can be selected in any combination manner, and will not be described in detail herein.
A combination of sodium laureth sulfate, cocamide DEA, cocamidopropyl betaine and lauryl glucoside is preferred.
The surfactant is preferably the combination of sodium laureth sulfate, cocamide DEA, cocamidopropyl betaine and lauryl glucoside, because the combination mode can enable the whole shower gel system to be more stable, and can enable foams to be fine and soft, and the shower gel is easy to wash and clean and has good skin feel. When the following proportional relationships are combined, the effect is better.
Preferably, the mass ratio of the sodium laureth sulfate, the cocamide DEA, the cocamidopropyl betaine and the lauryl glucoside is (10-20): (2-4): (1-2).
The specific point value in the (10-20) can be 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 and the like.
The specific point value in (2-4) can be 2, 3, 4, etc.
Specific point values in the (1-2) may be 1, 1.5, 2, and the like.
Specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the chelating agent comprises disodium EDTA.
Preferably, the thickener comprises sodium chloride.
Preferably, the pH adjusting agent comprises citric acid and/or sodium citrate.
Preferably, the humectant comprises any one or a combination of at least two of glycerol, propylene glycol, 1, 3-butylene glycol, sorbitol, polyethylene glycol, hyaluronic acid, ceramide or collagen; the combination of at least two of the above-mentioned compounds, such as the combination of glycerin and propylene glycol, the combination of 1, 3-butylene glycol and sorbitol, the combination of hyaluronic acid and ceramide, etc., can be selected in any combination manner, and will not be described in detail herein. Glycerol is preferred.
Preferably, the bath cream for pets further comprises 0-1 part of perfume, but not 0, such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like, and specific points in the numerical range can be selected, and are not repeated herein.
In a second aspect, the present invention provides a preparation method of the pet shower gel for improving skin micro-ecology according to the first aspect, the preparation method comprising the steps of:
(1) Mixing a chelating agent with water to obtain a first mixed solution;
(2) Mixing the first mixed solution obtained in the step (1) with a surfactant to obtain a second mixed solution;
(3) And (3) mixing the second mixed solution obtained in the step (2), the probiotic fermented extract, ecological nutrients, a humectant, a thickener, a pH regulator and a preservative to obtain the shower gel for pets, which is used for improving skin micro-ecology.
The preparation process of the pet shower gel for improving skin micro-ecology, disclosed by the invention, is simple and easy to operate, is very suitable for large-scale industrial production, and has obvious practicability and practical significance.
Preferably, the mixing temperature in step (1) is 80-85 ℃, for example, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃ and the like, and the mixing time is 5-10min, for example, 5min, 6min, 7min, 8min, 9min, 10min and the like, and specific values within the above numerical ranges can be selected, which is not described herein again.
Preferably, the mixing temperature in the step (2) is 60-70 ℃, such as 60 ℃, 62 ℃, 64 ℃, 65 ℃, 66 ℃, 68 ℃, 70 ℃ and the like, and the mixing time is 5-15min, such as 5min, 6min, 7min, 8min, 10min, 12min, 15min and the like, and specific values in the above numerical value ranges can be selected, which is not described herein again.
Preferably, the mixing temperature in step (3) is 40-50 ℃, for example, 40 ℃, 42 ℃, 44 ℃, 45 ℃, 46 ℃, 48 ℃, 50 ℃ and the like, the mixing time is 20-40min, for example, 20min, 22min, 25min, 30min, 32min, 35min, 40min and the like, and specific values within the above numerical ranges can be selected, which is not described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
the bath cream for pets, disclosed by the invention, creatively combines the probiotic fermentation extract, ecological nutrients and other conventional additive components, including a surfactant, a chelating agent, a humectant, a thickener, a pH regulator, a preservative and water, so that the bath cream has excellent effects of improving the microecological balance of skin and repairing skin barriers, and is remarkable in moisturizing effect, safe and non-irritant. The various components in the body wash for pets of the invention respectively play roles, and have synergistic effect on the beneficial effects, which is difficult to be expected.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples or comparative examples relate to the following raw materials for preparation with the following source information:
other preparation raw materials can also be purchased from commercial sources.
Example 1
The embodiment provides a bath cream for pets, which comprises the following components in percentage by weight: lactobacillus fermentation lysate 0.02%, yeast fermentation lysate 0.02%, lactobacillus fermentation product 0.01%; inulin 0.3%, alpha-glucan oligosaccharide 0.2%, galacto-oligosaccharide 0.1%, soybean oligosaccharide 0.1%; 10% of sodium laureth sulfate, 3% of cocamide DEA, 2% of cocamidopropyl betaine and 2% of lauryl glucoside; 0.1% of EDTA disodium; 3% of glycerol; 1% of NaCl; 0.1% of citric acid; 0.1 percent of methyl hydroxybenzoate and the balance of water.
The preparation method comprises the following steps:
(1) Mixing a chelating agent and water at 80 ℃ for 10min to obtain a first mixed solution;
(2) Mixing the first mixed solution obtained in the step (1) with a surfactant at 65 ℃ for 10min to obtain a second mixed solution;
(3) And (3) mixing the second mixed solution obtained in the step (2), the probiotic fermented extract, the ecological nutrient, the humectant, the thickener, the pH regulator and the preservative at 45 ℃ for 30min to obtain the shower gel for the pet for improving the skin micro-ecology.
Example 2
The embodiment provides a bath cream for pets, which comprises the following components in percentage by weight: lactobacillus fermentation lysate 0.01%, two split yeast fermentation lysate 0.01%, lactobacillus fermentation product 0.01%; inulin 0.3%, alpha-glucan oligosaccharide 0.3%, galacto-oligosaccharide 0.1%, soybean oligosaccharide 0.2%; sodium laureth sulfate 10%, cocamide DEA 2%, cocamidopropyl betaine 1%, lauryl glucoside 1%; 0.1 percent of EDTA disodium; 3% of glycerol; 1% of NaCl; 0.1% of citric acid; 0.1 percent of methyl hydroxybenzoate and the balance of water.
The preparation method comprises the following steps:
(1) Mixing a chelating agent and water at 80 ℃ for 10min to obtain a first mixed solution;
(2) Mixing the first mixed solution obtained in the step (1) with a surfactant at 60 ℃ for 15min to obtain a second mixed solution;
(3) And (3) mixing the second mixed solution obtained in the step (2), the probiotic fermented extract, the ecological nutrient, the humectant, the thickening agent, the pH regulator and the preservative at 40 ℃ for 40min to obtain the skin micro-ecological shower gel for pets.
Example 3
The embodiment provides a bath cream for pets, which comprises the following components in percentage by weight: lactobacillus fermentation lysate 0.02%, two split yeast fermentation lysate 0.01%, lactobacillus fermentation product 0.01%; inulin 0.2%, alpha-glucan oligosaccharide 0.2%, galacto-oligosaccharide 0.1%, soybean oligosaccharide 0.1%; 10% of sodium laureth sulfate, 2% of cocamide DEA, 1% of cocamidopropyl betaine and 2% of lauryl glucoside; 0.1 percent of EDTA disodium; 3% of glycerol; 1% of NaCl; 0.1 percent of citric acid; 0.1 percent of methyl hydroxybenzoate and the balance of water.
The preparation method comprises the following steps:
(1) Mixing a chelating agent and water at 85 ℃ for 5min to obtain a first mixed solution;
(2) Mixing the first mixed solution obtained in the step (1) with a surfactant at 70 ℃ for 5min to obtain a second mixed solution;
(3) And (3) mixing the second mixed solution obtained in the step (2), the probiotic fermented extract, the ecological nutrient, the humectant, the thickening agent, the pH regulator and the preservative at 50 ℃ for 20min to obtain the skin micro-ecological shower gel for pets.
Example 4
The present example provides a bath lotion for pets, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are as follows: second split yeast fermentation lysate 0.03%, lactobacillus fermentation product 0.02%; the other components and contents were kept constant. The preparation method is the same as example 1.
Example 5
This example provides a bath lotion for pet, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are: lactobacillus fermentation lysate 0.03%, lactobacillus fermentation product 0.02%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 6
The present example provides a bath lotion for pets, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are as follows: lactobacillus fermentation lysate 0.025%, yeast fermentation lysate 0.025%; the other components and contents were kept constant. The preparation method is the same as example 1.
Example 7
This example provides a bath lotion for pet, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are: lactobacillus fermentation lysate 0.5%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 8
This example provides a bath lotion for pet, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are: 0.5% of a yeast bifidus fermentation product lysate; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 9
This example provides a bath lotion for pet, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are: 0.5% of lactobacillus fermentation product; the other components and contents were kept constant. The preparation method is the same as example 1.
Example 10
This example provides a bath lotion for pet, which is different from the formulation of example 1 only in that the components of the probiotic fermented extract are: lactobacillus fermentation lysate 0.01%, two split yeast fermentation lysate 0.01%, lactobacillus fermentation product 0.03%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 11
The present example provides a bath lotion for pets, which is different from the formulation of example 1 only in that the ecological nutrients comprise the following components: 0.3% of alpha-glucan oligosaccharide, 0.2% of galacto-oligosaccharide and 0.2% of soybean oligosaccharide; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 12
The present example provides a bath lotion for pets, which is different from the formulation of example 1 only in that the ecological nutrients comprise the following components: inulin 0.3%, galacto-oligosaccharide 0.2%, soybean oligosaccharide 0.2%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 13
The present example provides a bath cream for pets, which is different from the formula of example 1 only in that the components of the ecological nutrients are: inulin 0.3%, alpha-glucan oligosaccharide 0.2%, soybean oligosaccharide 0.2%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 14
The present example provides a bath cream for pets, which is different from the formula of example 1 only in that the components of the ecological nutrients are: inulin 0.3%, alpha-glucan oligosaccharide 0.2%, fructo-oligosaccharide 0.1%, xylo-oligosaccharide 0.1%; the other components and contents were kept constant. The preparation method is the same as example 1.
Example 15
The present example provides a bath lotion for pets, which is different from the formulation of example 1 only in that the ecological nutrients comprise the following components: inulin 0.1%, alpha-glucan oligosaccharide 0.1%, galacto-oligosaccharide 0.2%, soybean oligosaccharide 0.3%; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 16
The present embodiment provides a bath cream for pets, which is different from the formulation of embodiment 1 only in that the moisturizer comprises the following components: 3% of 1, 3-butanediol; the other components and contents were kept constant. The preparation method is the same as that of example 1.
Example 17
The present embodiment provides a bath cream for pets, which is different from the formulation of embodiment 1 only in that the moisturizer comprises the following components: 3% of sorbitol; the other components and contents were kept constant. The preparation method is the same as example 1.
Comparative example 1
The present comparative example provides a bath cream for pets, the formulation of which differs from example 1 only in that it does not contain the probiotic fermented extract component, and the other components and amounts remain the same.
Comparative example 2
This comparative example provides a bath lotion for pets, which formulation differs from example 1 only in that it does not contain the ecological nutrient components, and the other components and amounts remain the same.
Test example 1:
the safety performance test was performed on the body wash for pets provided in examples 1 to 17, by the following method:
(1) Haemolysis test of erythrocytes
Preparation of erythrocyte suspension: selecting healthy rabbit, taking 9mL of blood from heart, adding 1mL of 2% potassium oxalate solution, centrifuging, discarding supernatant, diluting the precipitate to 20mL with 20mmol/L PBS solution, and storing at 4 ℃ for later use. Select samples were diluted with PBS solution to different concentrations, with 5 concentration gradients set for each sample. Adding 200 μ L of the above erythrocyte suspension (final concentration of the sample is controlled to be 5, 10, 20, 50, 100mg/mL respectively) into 10mL of diluent of the sample to be tested, taking distilled water as total blood-dissolving control, taking PBS solution as negative control, mixing gently, incubating at 37 deg.C for 30min, centrifuging at 2000r/min for 10min, collecting supernatant, and testing its absorbance at 560nm with spectrophotometer (A) 560 ) Calculating the hemolysis rate according to the following formula;
the hemolysis rate-sample concentration standard curve was plotted, and the sample concentration at which 50% of erythrocytes were Hemolyzed (HD) was calculated 50 )。
(2) Protein denaturation experiments:
diluting the sample to 10g/L with PBS solution, collecting 10mL dilution of the sample to be tested, adding 200 μ L of the above erythrocyte suspension, using distilled water as blank control, dissolving with 1mg/mL Sodium Dodecyl Sulfate (SDS)Mixing the solution as positive control, incubating at 37 deg.C for 30min, centrifuging at 2000r/min for 10min, collecting supernatant, and testing absorbance A at 540nm and 575nm with spectrophotometer 540 And A 575 Calculating a protein Denaturation Index (DI) according to the following formula;
wherein R is 1 = blank control group A 575 Blank control group A 540 ，R 2 = Experimental group A 575 Experimental group A 540 ，R 3 = Positive control group A 575 Positive control group A 540 。
Evaluating the irritation of the sample to be tested according to the L/D value, wherein the L/D value is HD 50 DI, erythrocyte hemolysis assay irritation grading criteria are shown in Table 1 below:
TABLE 1
| L/D | Grading |
| >100 | Has no irritation |
| 10<L/D≤100 | Micro-stimulation property |
| 1<L/D≤10 | Mild irritation |
| 0.1<L/D≤1 | Moderate irritation |
The results of the above-described hemolysis test and protein denaturation test are shown in Table 2 below:
TABLE 2
As can be seen from the data in the table 2, the bath cream for the pets is mild, has no stimulation, and is high in safety; the invention relates to a sample HD when 50% red blood cells of shower gel for pets are hemolyzed 50 The protein denaturation index DI is above 368mg/L and below 0.77.
Test example 2:
the bath cream for pets provided in examples 1 to 17 and comparative examples 1 to 2 was tested for diversity and abundance of skin microorganisms shannon as follows:
95 test labrador dogs are selected, and male dogs with the age of about 3 months (the physique and the health condition are basically consistent). The test dogs were randomly divided into 19 groups of 5 dogs each, and all were kept in the same environment, free-moving, and free-drinking. The using method comprises the following steps: the samples were applied 1 time every 3 days to each dog, 7g each time, and the residence time of the samples on the skin was about 10min for one month of continuous application.
The shannon diversity index was analyzed by means of a microorganism detector and bioinformatics software, and the relative abundance of gluconobacteriaceae and moraxeceae was evaluated. The test results are shown in table 3 (data are presented as mean values):
TABLE 3
| Test sample | Shannon diversity index | Changes in abundance of gluconobacteriaceae | Moraxeridae abundance changes |
| Example 1 | 1.35 | -30.7％ | 23.3％ |
| Example 2 | 1.26 | -29.2％ | 23.0％ |
| Example 3 | 1.19 | -28.5％ | 22.6％ |
| Example 4 | 1.06 | -27.1％ | 19.6％ |
| Example 5 | 1.02 | -26.5％ | 18.9％ |
| Example 6 | 1.05 | -27.1％ | 20.3％ |
| Example 7 | 1.15 | -28.0％ | 20.7％ |
| Example 8 | 1.05 | -25.6％ | 20.5％ |
| Example 9 | 1.12 | -26.9％ | 19.6％ |
| Example 10 | 1.08 | -26.8％ | 19.2％ |
| Example 11 | 0.98 | -21.2％ | 17.9％ |
| Example 12 | 0.91 | -25.8％ | 16.2％ |
| Example 13 | 0.86 | -23.4％ | 14.2％ |
| Example 14 | 0.89 | -20.8％ | 15.6％ |
| Example 15 | 0.89 | -22.5％ | 15.7％ |
| Example 16 | 1.26 | -29.0％ | 23.3％ |
| Example 17 | 1.32 | -28.9％ | 22.7％ |
| Comparative example 1 | 0.76 | -17.1％ | 12.5％ |
| Comparative example 2 | 0.69 | -15.8％ | 11.9％ |
Wherein a lower shannon diversity index value indicates a lower microbial diversity, which is often associated with skin unhealthy. Wherein the staphylococcaceae family is associated with skin diseases such as atopic dermatitis and psoriasis; moraxeaceae belongs to the phylum Proteobacteria, gamma Proteobacteria, and has been shown to have potential anti-inflammatory properties, which are associated with immune homeostasis.
From the data results in table 3, it can be seen that: the shower gel for pets, disclosed by the invention, can increase the microbial diversity of pet skin, promote the generation of beneficial bacteria and reduce harmful bacteria.
Test example 3:
the pet body washes provided in examples 1 to 17 and comparative examples 1 to 2 were subjected to a microbial barrier repair test as follows:
95 test labrador dogs are selected and male, wherein the age of the labrador dogs is about 3 months (the physique and the health condition are basically consistent). The test dogs were kept in the same environment, freely moving, and freely drinking water. The using method comprises the following steps: the samples were applied 1 time every 3 days to each dog, 7g each time, and the residence time of the samples on the skin was about 10min for one month of continuous application.
The method comprises the steps of conducting hair removal treatment on the same area on the back of all test dogs, dipping a small amount of physiological saline in a sterilized cotton swab, wiping the cotton swab for 50 times, soaking the cotton swab into the physiological saline with the same volume, vibrating the cotton swab by using a vortex oscillator, and dispersing bacteria into the physiological saline. This sample was taken as the initial skin colony count and was designated A 0 (ii) a Wherein the amount of Staphylococcus aureus is B 0 。
And then, dipping a small amount of physiological saline in a sterilized cotton swab at intervals of 6 hours and 12 hours respectively to wipe the cotton swab back and forth for 50 times, soaking the cotton swab in the physiological saline with the same volume, and oscillating by using a vortex oscillator to disperse bacteria in the physiological saline. The recovery value of the number of skin colonies of this sample was recorded as A 1 Wherein the amount of Staphylococcus aureus is B 1 。
Wherein the recovery rate of skin colonies = [ (A) 0 -A 1 )/A 0 ]X is 100%; inhibition rate of staphylococcus aureus = [ (B) 0 -B 1 )/B 0 ]×100％。
The specific test results are shown in table 4:
TABLE 4
As can be seen from the test results of table 4: the shower gel for pets, disclosed by the invention, has the effect of promoting the recovery of skin bacterial colonies and simultaneously inhibiting the growth of staphylococcus aureus.
The applicant states that the present invention is described by the above examples to describe a body wash for pet and a preparation method thereof, but the present invention is not limited to the above examples, that is, it does not mean that the present invention is implemented by relying on the above examples. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (13)
1. The shower gel for pets for improving skin micro-ecology is characterized by comprising the following raw materials in parts by weight: 0-0.7 part but not 0 part of probiotic fermented extract, 0-1 part but not 0 part of ecological nutrient, 10-40 parts of surfactant, 0.05-0.2 part of chelating agent, 0.5-5 parts of humectant, 0.1-2 parts of thickening agent, 0.01-0.2 part of pH regulator, 0.1-1 part of preservative and 40-90 parts of water;
the probiotic fermentation extract is a combination of a lactobacillus fermentation lysate, a yeast dehiscence lysate and a lactobacillus fermentation product;
the ecological nutrient is a combination of inulin, alpha-glucan oligosaccharide, galacto-oligosaccharide and soybean oligosaccharide;
the mass ratio of the lactobacillus fermentation lysate to the secondary fission yeast fermentation product lysate to the lactobacillus fermentation product is (1-2): (1-2): 1;
the mass ratio of the inulin to the alpha-glucan oligosaccharide to the galacto-oligosaccharide to the soybean oligosaccharide is (2-3) to (1-2).
2. A skin micro-ecology improving body wash for pets according to claim 1, wherein said surfactant comprises any one of sodium laureth sulfate, cocamide DEA, cocamide propyl betaine or lauryl glucoside, or a combination of at least two thereof.
3. A skin micro-ecology improving body wash for pets according to claim 2, wherein said surfactant is a combination of sodium laureth sulfate, cocamide DEA, cocamide propyl betaine and lauryl glucoside.
4. The skin micro-ecological improving shower gel for pets according to claim 3, wherein the mass ratio of sodium laureth sulfate, cocamide DEA, cocamide propyl betaine and lauryl glucoside is (10-20): (2-4): (1-2).
5. The skin micro-ecology improving body wash for pets according to claim 1, wherein said chelating agent comprises disodium EDTA.
6. A skin micro-ecology improving body wash for pets according to claim 1, wherein said thickener comprises sodium chloride.
7. The skin micro-ecology improving body wash for pets according to claim 1, wherein said pH adjuster comprises citric acid and/or sodium citrate.
8. The skin micro-ecology improving shower gel for pets according to claim 1, wherein the moisturizing agent comprises any one of glycerin, propylene glycol, 1, 3-butylene glycol, sorbitol, polyethylene glycol, hyaluronic acid, ceramide, or collagen, or a combination of at least two of them.
9. The body wash for pets for improving skin micro ecology according to claim 8, wherein said moisturizing agent is glycerin.
10. A method of preparing a pet shower gel for improving skin micro ecology according to any one of claims 1 to 9, comprising the steps of:
(1) Mixing a chelating agent with water to obtain a first mixed solution;
(2) Mixing the first mixed solution obtained in the step (1) with a surfactant to obtain a second mixed solution;
(3) And (3) mixing the second mixed solution obtained in the step (2), the probiotic fermented extract, the ecological nutrient, the humectant, the thickening agent, the pH regulator and the preservative to obtain the shower gel for pets, which is used for improving skin micro-ecology.
11. The method of preparing a pet shower gel for improving skin micro ecology according to claim 10, wherein the mixing temperature in the step (1) is 80-85 ℃ and the mixing time is 5-10min.
12. The method of preparing a pet shower gel for improving skin micro ecology according to claim 10, wherein the mixing temperature in the step (2) is 60-70 ℃ and the mixing time is 5-15min.
13. The method of preparing a pet shower gel for improving skin micro ecology according to claim 10, wherein the mixing temperature in the step (3) is 40-50 ℃ and the mixing time is 20-40min.
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| CN103315921A (en) * | 2013-06-28 | 2013-09-25 | 广州丹奇日用化工厂有限公司 | Shower gel |
| CN111249217A (en) * | 2020-03-19 | 2020-06-09 | 西安润玉医疗科技有限公司 | Cleansing liquid for adjusting skin micro-ecological balance and preparation method thereof |
| CN111658600A (en) * | 2020-07-31 | 2020-09-15 | 山东国力生物科技有限公司 | Biological nursing lotion and preparation method thereof |
| CN112426373A (en) * | 2020-11-27 | 2021-03-02 | 佛山市南海东方澳龙制药有限公司 | Pet shampoo with functions of treating ectoparasite dermatosis and resisting bacteria and preparation method thereof |
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| US20170368109A1 (en) * | 2016-06-28 | 2017-12-28 | Animal Cell Therapies Inc. | Probiotic Fermentation Products |
| CN111265470A (en) * | 2020-03-30 | 2020-06-12 | 西安润玉医疗科技有限公司 | Microecological restoration composition and preparation method thereof |
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| CN103315921A (en) * | 2013-06-28 | 2013-09-25 | 广州丹奇日用化工厂有限公司 | Shower gel |
| CN111249217A (en) * | 2020-03-19 | 2020-06-09 | 西安润玉医疗科技有限公司 | Cleansing liquid for adjusting skin micro-ecological balance and preparation method thereof |
| CN111658600A (en) * | 2020-07-31 | 2020-09-15 | 山东国力生物科技有限公司 | Biological nursing lotion and preparation method thereof |
| CN112426373A (en) * | 2020-11-27 | 2021-03-02 | 佛山市南海东方澳龙制药有限公司 | Pet shampoo with functions of treating ectoparasite dermatosis and resisting bacteria and preparation method thereof |
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