CN102688158A - Additive-free anti-aging cosmetic and preparation method thereof - Google Patents
Additive-free anti-aging cosmetic and preparation method thereof Download PDFInfo
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Abstract
The invention provides an additive-free anti-aging cosmetic and a preparation method thereof. The cosmetic is prepared from the following components in percentage by weight: a component A: 0.01-0.2 percent of sodium hyaluronate, 2-10 percent of 1,3-butanediol, 3-5 percent of 1,2-pentanediol and 70-90 percent of water; a component B: 0.3-1.0 percent of a mixture of 1,2-hexanediol and 1,2-ethohexadiol; a component C: 0.5-5 percent of collagen; a component D: 0.01-0.2 percent of carnosine; and a component E: 0.05-0.3 percent of natural essence. Every 100 percent of the additive-free anti-aging cosmetic comprises 0.3-1 percent of component B, 0.5-5 percent of component C, 0.01-0.5 percent of component D, 0.05-0.5 percent of component E and the balance of component A.
Description
Technical field
The present invention relates to a kind of cosmetics, relate in particular to a kind of prescription and method for preparing of not having the anti-aging cosmetics of interpolation.
Background technology
The Along with people's growth in the living standard, people require increasingly highly to cosmetics, but the antidotal cosmetics general utility functions of selling in the market are more single, DeGrain.
On the one hand, at present defying age has become main market players, and aging has many-sided reason, wherein mainly contains the existence, telomerase activation disappearance, macromolecules cross-linking of interior free yl etc.Wherein, The existence of interior free yl is the main cause that causes the generation of skin aging phenomenon; Free radical (ROS, RCS) mainly contains the effect of two aspects: the one, act on the polyunsaturated fatty acid of cell membrane, and form MDA, the protein effect on material such as the malonaldehyde of generation and the cell membrane and generate brown pigment; Be deposited in skin, form mottle.The 2nd, can make the crosslinked and degeneration of collagen protein, elastic fibers in the epiderm skin, become fragile and follow the string.The raw material that the existing product that generally is used for free radical resisting uses mainly contains glutathion, carotene, vitamin C, vitamin E etc.; These raw materials mainly are its antioxidations; Hinder free radical and form peroxide, act on more singlely, can not promote synthesizing of collagen protein.
To above problem, need to solve: one, remove interior free yl two, promote proteic synthetic three, the moistening effect of strengthening skin of collagen in the body from three aspects.
On the other hand, the whole world has 40%-70% people that sensitivity skin tendency is arranged, and life-time service contains the skin care item of antiseptic, spice, pigment and mineral oil and causes skin erythema, decortication, pimple and rash responsive phenomenon such as itch to occur easily.Normally the consuming capacity are than higher colony in responsive skin consumer, and antiseptic, artificial color, artificial flavors and mineral oil are maximum cosmetics stimulus.The nothing interpolation cosmetics that exploitation does not contain antiseptic, artificial flavors, artificial color and mineral oil can really satisfy these large numbers of consumer demands.
Summary of the invention
The present invention is directed to a series of problems of existing anti-aging cosmetics; With 1,3 butylene glycol, 1,2-pentanediol, 1; 2-hexanediol, 1; 2-ethohexadiol and carnosine, collagen protein are applied in the anti-aging cosmetics, have avoided using the sensitivity of traditional preservatives to skin, and have fundamentally solved the old and feeble problem of skin.
The invention provides a kind of anti-aging cosmetics that does not have interpolation, comprise following component by weight percentage:
A component: hyaluronate sodium 0.01-0.2%, 1,3 butylene glycol 2-10%, 1,2-pentanediol 3-5%, water 80-80.5%;
The B component: 1,2-hexanediol and 1,2-ethohexadiol mixture 0.3-1.0%;
C component: collagen protein 0.5-5%;
D component: carnosine 0.01-0.2%;
E component: natural essence 0.05-0.3%;
There not to be the anti-aging cosmetics that adds is 100%, and said B component is 0.3-1%, and said C component is 0.5-5%, and said D component is 0.01-0.5%, and said E component is 0.05-0.5%, and surplus is the A component.
Among them, collagen purchased from Beijing Yum Andean bio-engineering company, is the use of modern biological extraction technology to extract collagen lyophilized powder; carnosine in the virtues of purchasing Xin Company, its main chemical composition of β-alanine-L-histidine .
Preferably, said 1,2-hexanediol and 1, the weight ratio of 2-ethohexadiol is 1:1.
Preferably, said natural essence is natural rose essential and the SP-115C of mass ratio 1:4.
Wherein, SP-115C is a kind of solubilizing agent.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds C component, D component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds C component, E component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, C component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, E component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, C component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
The invention provides a kind of method for preparing of cosmetics, comprise following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, D component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Preferably, said C component and D component add after using the cooled deionized water dissolving of heating fully respectively again.
The invention has the beneficial effects as follows: the synergism that passes through each composition by the cosmetics of above-mentioned formulation; Microorganism there is certain inhibitory action; Reach the antiseptical effect; Adopt the defying age compositions of preserving moisture such as collagen protein and carnosine to cooperate jointly simultaneously, guaranteed product preserve moisture, comprehensive effect of aspect such as crease-resistant, reparation, concrete effect is following:
Antiseptic effect: the 1,3 butylene glycol of use, 1,2-pentanediol, 1; 2-hexanediol and 1, the 2-ethohexadiol has the good restraining effect to microorganism, and wherein 1; The 3-butanediol plays auxiliary anticorrosion, specifically, and 1; The 2-pentanediol obtains its MIC to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, aspergillus niger and is respectively: 3.2%, 1.6%, 3.2%, 1.6%, 1.6% through agar dilution.1,2-hexanediol and 1, the 2-ethohexadiol is respectively the MIC of escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, aspergillus niger: 0.31%, 0.63%, 0.31%, 0.16%, 0.08%.
Defying age: the collagen protein of use is a kind of born multifilament protein, is the most basic pillar of skin texture.It has makes skin softness and the ability that keeps moisture, accounts for 90% of total skin dose.On the one hand because a large amount of existence of molecule outside hydrophilic group carboxyl and hydroxyl etc.; Complicated in addition biomacromolecule structure makes it can a large amount of moisture of occlusion, and can form the epithelium of similar epidermal structure after using in skin surface; Protection skin; The lost naturally speed of the interior moisture of the skin that slows down makes it can have the good moisture preserving effect, reaches the purpose that keeps the moist degree of skin.Possess the advantages of good skin compatibility on the other hand, be easy to absorbed, after the absorption, form a large amount of micromolecule oligopeptide or free amino acid by skin, its peculiar hydroxyproline composition especially, thus give skin layer necessary nutrient.Moreover; The membranaceous material of class skin that skin surface forms has good permeability; Moisture and air can access diffusion freely; Also can keep out of the damage of undesirable elements such as extraneous dust, antibacterial, ultraviolet simultaneously, guarantee that skin histology has a good physiological environment, accelerate tissue repair speed skin.
Employed carnosine is a kind of natural component among the present invention, on two different horizontal, brings into play senile-resistant efficacy on the one hand: 1) protection-obstruction radical reaction and glycosylation; 2) repair-prevent that products of oxidative stress and advanced glycation dead end product from generating.On the other hand, cancellation reactive oxygen free radical and carbonyl free radical suppress matrix metalloproteinase 1 comprehensively, and the generation of stimulation collagen delays the process that telomere shortens.Thereby reach antidotal purpose.
Description of drawings
Fig. 1 is R2, R5, the R7 value variation diagram of the embodiment of the invention 8.
The specific embodiment
Below in conjunction with accompanying drawing, more excellent embodiment of the present invention is done further detailed description:
Embodiment 1:
The present invention does not have the anti-aging cosmetics of interpolation and comprises A component, B component, C component, D component, E component, and the A component is a deionization 88.93%, hyaluronate sodium 0.01%, 1; 3-butanediol 10%, 1,2-pentanediol 5%; B component 1,2-hexanediol 0.5%, 1,2-ethohexadiol 0.5%; C collagen protein 5%, D carnosine 0.01%, E natural essence 0.05%.
Method for preparing: 1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes; 2) stirring is cooled to 40 ℃, adds C component, D component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again; 3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.C, D component are complete with the cooled deionized water dissolving of heating respectively.
Embodiment 2:
The A component is a deionization 93.5%, hyaluronate sodium 0.2%, 1,3 butylene glycol 2%, 1,2-pentanediol 3%, B component 1,2-hexanediol 0.15%, 1,2-ethohexadiol 0.15%, C collagen protein 0.5%, D carnosine 0.2%, E natural essence 0.3%.
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds C component, E component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Embodiment 3:
The A component is a deionization 85.8%, hyaluronate sodium 0.1%, 1,3 butylene glycol 6%, 1,2-pentanediol 4%, B component 1,2-hexanediol 0.4%, 1,2-ethohexadiol 0.4%, C collagen protein 3%, D carnosine 0.1%, E natural essence 0.2%.
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, C component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Embodiment 4:
The A component is a deionization 83.6%, hyaluronate sodium 0.05%, 1,3 butylene glycol 8%, 1,2-pentanediol 4.5%, B component 1,2-hexanediol 0.3%, 1,2-ethohexadiol 0.3%, C collagen protein 3%, D carnosine 0.15%, E natural essence 0.1%.
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, E component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Embodiment 5:
The A component is a deionization 85.25%, hyaluronate sodium 0.15%, 1,3 butylene glycol 6%, 1,2-pentanediol 4%, B component 1,2-hexanediol 0.2%, 1,2-ethohexadiol 0.2%, C collagen protein 4%, D carnosine 0.05%, E natural essence 0.15%.
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, C component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Embodiment 6:
The A component is a deionization 82.17%, hyaluronate sodium 0.08%, 1,3 butylene glycol 10%, 1,2-pentanediol 4%, B component 1,2-hexanediol 0.25%, 1,2-ethohexadiol 0.25%, C collagen protein 3%, D carnosine 0.2%, E natural essence 0.05%.
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, D component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
Select for use by the prescription of embodiment 1 and the cosmetics of method for preparing preparation its various aspects of performance is done test, concrete test experiments is following:
Embodiment 7: microorganism challenge experiment:
1, method
Adopt the antiseptic efficiency evaluation method that generally adopts both at home and abroad, be CTFA recommend once add the test of bacterium preservation challenge property.
2, the testing time:
One-period was done once check in per 7 days, and the time is 28 days altogether.
3, testing standard:
1) the 28th day the time; Contain antibacterial or mycete in the sample>103cfu/g (ml); This sample can not show that the protective system of sample can not play the inhibition action of microorganisms effectively through the challenge experiment of microorganism attack, and product is easy to receive contamination by micro in producing, preserve and using.
2) the 28th day the time; Contain antibacterial or mycete in the sample at 102cfu/g (ml)-103cfu/g (ml), through the challenge experiment, promptly protein or other animals and plants material composition are not high especially to this sample in product conditionally; The hygienic conditions of producing simultaneously meet the requirements; When packing material was difficult for secondary pollution takes place, this protective system can use, otherwise can not.
3) the 28th day the time, contain antibacterial or mycete in the sample, show that the protective system of this sample has stronger pressing down to kill effect to microorganism, through the challenge test at 10cfu/g (ml)-102cfu/g (ml).Product is not easy to receive microbial contamination when producing, preserving and using.
4) from the 7th day, < 10cfu/>g (ml), the protective system that this sample is described has the inhibitory or killing effect of extra-heavy to microorganism, through the challenge test for antibacterial in the sample or mycete.Product is not easy by microbial contamination when producing, preserving and using very much.
4, experimental strain:
1) with the staphylococcus aureus of buying, bacillus pyocyaneus, aspergillus niger, white candida mycoderma, colibacillus of excrement are processed with the workshop mixed vaccine and are mixed outstanding bacterium liquid,
2) extract workshop mixed cell and mycete yeast, inoculated and cultured
3) to add bacterium amount be 8.9 * 106cfu/ml to the antibacterial mixing suspension.It is 5.8 * 104 cfu/ml that the fungus mixing suspension adds the bacterium amount
Table 1 test result
| Testing time | The 0th day | The 7th day | The 14th day | The 21st day | The 28th day |
| Total number of bacteria | 8900000 | 0 | 0 | 0 | 0 |
| Total number of fungi | 58000 | 0 | 0 | 0 | 0 |
5, interpretation of result:
These cosmetics have strong inhibitory or killing effect to microorganism, through preservation challenge.
Embodiment 8: the defying age experiment:
1, experiment crowd:
The user of 30 health.
2, testing standard:
Skin elasticity test: use Reviscometer RV600 (elastic fibrous tissue's test probe) survey of the skin elasticity tester MPA580 of German Courage+Khazaka (CK) company to average for three times.
3, method of testing:
Facial left and right sides cheekbone, nose and pupil intersection place left and right sides cheek, temple and corners of the mouth intersection place left and right sides are as pilot region in the experiment; The blank value (R2, R5, R7) of 30min behind elder generation's measurement facial cleansing; Standard experimenter or care-giver adhere to using sample every day sooner or later then, test R2, R5, the R7 value of 1 week, 2 weeks, 3 weeks, 4 all backs pilot region skin elasticitys respectively.
R2=Ua/Uf R5=Ur/Ue R7=Ur/Uf wherein
Uf---skin maximum tension amount
After Ue---constant negative pressure is added on the skin, the amount of tension of skin during 0.1 second, location elastic part amount of tension.
Ur---after the cancellation negative pressure, the skin attitude that will restore to the original state rapidly is divided into elastic score value Ur equally, promptly cancels negative pressure after 0.1 second, and recovery value and the viscoelasticity of skin partly are worth, or title plasticity partly is worth.
Ua---from the recovery value of cancellation negative pressure skin when the follow-on test skin surface adds negative pressure more next time.
When generally speaking measuring, R2, R5, R7 are more near 1, and skin elasticity is good more
4, search time:
Whole research is 4 weeks by a definite date, and researcher is in the 0th week, 1 week, 2 weeks, and 3 weeks, 4 weeks are carried out the clinical trial outcome evaluation.
5, test data:
Use 4 weeks of the said goods, in the 0th week, 1 week, 2 weeks, 3 weeks, 4 weeks are carried out the clinical trial outcome evaluation.
Table 1: test data
6, experimental analysis:
Can find out that from Fig. 1 and table 1 value of R2, R5, R7 is significantly improved, around, the R2 value has improved 57.79%, and R5 has improved 67.60%, and R7 has improved 97.69%, therefore, can prove that these cosmetics have anti-aging effects preferably to skin.
Above content is to combine concrete preferred implementation to the further explain that the present invention did, and can not assert that practical implementation of the present invention is confined to these explanations.For the those of ordinary skill of technical field under the present invention, under the prerequisite that does not break away from the present invention's design, can also make some simple deduction or replace, all should be regarded as belonging to protection scope of the present invention.
Claims (10)
1. an anti-aging cosmetics that does not have interpolation is characterized in that, comprises following component by weight percentage:
A component: hyaluronate sodium 0.01-0.2%, 1,3 butylene glycol 2-10%, 1,2-pentanediol 3-5%, water 70-90%;
The B component: 1,2-hexanediol and 1,2-ethohexadiol mixture 0.3-1.0%;
C component: collagen protein 0.5-5%;
D component: carnosine 0.01-0.2%;
E component: natural essence 0.05-0.3%;
There not to be the anti-aging cosmetics that adds is 100%, and said B component is 0.3-1%, and said C component is 0.5-5%, and said D component is 0.01-0.5%, and said E component is 0.05-0.5%, and surplus is the A component.
2. the anti-aging cosmetics that nothing as claimed in claim 1 is added is characterized in that, and is said 1,2-hexanediol and 1, and the weight ratio of 2-ethohexadiol is 1:1.
3. the anti-aging cosmetics that nothing as claimed in claim 1 is added is characterized in that said natural essence is natural rose essential and the SP-115C of mass ratio 1:4.
4. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, and said method comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds C component, D component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
5. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds C component, E component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
6. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, C component and E component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
7. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds D component, E component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
8. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, C component and D component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
9. the method for preparing of cosmetics is characterized in that, comprises the anti-aging cosmetics that adds like the described nothing of claim 1 to 3, comprises following several steps:
1) the A component is joined in the main pot, be stirred and heated to 80-85 ℃, insulated and stirred 30 minutes;
2) stirring is cooled to 40 ℃, adds E component, D component and C component successively, after the stirring homogenizing is uniformly dispersed, is cooled to 35 ℃ again;
3) discharging is promptly processed and is not had the anti-aging cosmetics that adds.
10. like each described method of claim 4 to 8, it is characterized in that said C component and D component add after using the cooled deionized water dissolving of heating fully respectively again.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156786A (en) * | 2013-03-06 | 2013-06-19 | 张朝群 | Non-additivated antisenescence cosmetic |
| CN105796476A (en) * | 2016-05-24 | 2016-07-27 | 广州丹奇日用化工厂有限公司 | Moisturizing and senile-resistant cosmetic containing sagittaria sagittifolia extracts and preparation method thereof |
| CN105902402A (en) * | 2015-01-18 | 2016-08-31 | 西姆莱斯股份公司 | Active mixture |
| CN106913510A (en) * | 2017-04-20 | 2017-07-04 | 合肥卡迪尔化妆品有限公司 | One kind attains product collagen protein face |
| CN108125903A (en) * | 2018-01-19 | 2018-06-08 | 深圳光彩生命工程技术有限公司 | A kind of novel stem cells composite factor anti-aging cosmetics |
| CN114222554A (en) * | 2019-06-28 | 2022-03-22 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
| CN116807924A (en) * | 2023-08-31 | 2023-09-29 | 成都普什制药有限公司 | Collagen-containing skin anti-wrinkle composition, anti-wrinkle product and preparation method thereof |
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2012
- 2012-06-06 CN CN2012101837442A patent/CN102688158A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156786A (en) * | 2013-03-06 | 2013-06-19 | 张朝群 | Non-additivated antisenescence cosmetic |
| CN103156786B (en) * | 2013-03-06 | 2015-03-25 | 广州市美驰化妆品有限公司 | Non-additivated antisenescence cosmetic |
| CN105902402A (en) * | 2015-01-18 | 2016-08-31 | 西姆莱斯股份公司 | Active mixture |
| CN105796476A (en) * | 2016-05-24 | 2016-07-27 | 广州丹奇日用化工厂有限公司 | Moisturizing and senile-resistant cosmetic containing sagittaria sagittifolia extracts and preparation method thereof |
| CN106913510A (en) * | 2017-04-20 | 2017-07-04 | 合肥卡迪尔化妆品有限公司 | One kind attains product collagen protein face |
| CN108125903A (en) * | 2018-01-19 | 2018-06-08 | 深圳光彩生命工程技术有限公司 | A kind of novel stem cells composite factor anti-aging cosmetics |
| CN114222554A (en) * | 2019-06-28 | 2022-03-22 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
| CN114222554B (en) * | 2019-06-28 | 2024-03-12 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
| CN116807924A (en) * | 2023-08-31 | 2023-09-29 | 成都普什制药有限公司 | Collagen-containing skin anti-wrinkle composition, anti-wrinkle product and preparation method thereof |
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Application publication date: 20120926 |