CN116807924A - Collagen-containing skin anti-wrinkle composition, anti-wrinkle product and preparation method thereof - Google Patents
Collagen-containing skin anti-wrinkle composition, anti-wrinkle product and preparation method thereof Download PDFInfo
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- Cosmetics (AREA)
Abstract
The application discloses a collagen-containing skin anti-wrinkle composition, an anti-wrinkle product and a preparation method thereof, belonging to the technical field of skin care products, wherein the anti-wrinkle composition comprises the following components in parts by weight: 0.5-2 parts of hydrolyzed sodium hyaluronate, 0.1-0.5 part of sodium hyaluronate, 0.2-1 part of collagen, 0.5-2 parts of ectoin, 2-4 parts of hirudin, 0.01-0.05 part of carnosine and 200 parts of water; wherein the collagen comprises macromolecular collagen and micromolecular collagen. The essence has the remarkable effects of resisting wrinkles, repairing skin, enhancing barrier, moisturizing, shrinking pores and the like, and effectively solves the problems of the existing products.
Description
Technical Field
The application belongs to the technical field of skin care products, and particularly relates to a collagen-containing skin anti-wrinkle composition, an anti-wrinkle product and a preparation method thereof.
Background
Skin aging is natural aging and aging caused by environmental factors, generally after 25 years old, metabolism of female skin is gradually slow, balance between proliferation and differentiation of cells and aging and apoptosis of cells is disturbed, so that the scavenging capacity of excessive aging cells to free radicals in the body is reduced, and in addition, the skin aging cells continuously contact with the outside, external pollution factors such as ultraviolet rays and electromagnetic radiation and the like continuously generate a large amount of free radicals and active oxygen in the human body, the free radicals and the active oxygen can act with proteins in the skin, so that the proteins are spatially heterogeneous, or active groups in molecules are oxidized to cause protein denaturation, further, the proteins lose original functions, and the proteins comprise collagen and elastin in dermis layers, so that skin elasticity is reduced, and wrinkles are generated.
Currently, there are a wide variety of commercially available anti-wrinkle products, and the general formulation contains the following major active ingredients: collagen or hydrolyzed collagen components can form obvious skin tightening effect on skin in a very short time, but can not really achieve long-acting anti-wrinkle and tightening effects. The retinol has outstanding anti-aging and anti-wrinkle effects, but has poor stability and is easy to oxidize, so that the effectiveness of the retinol is limited, and the use effect of the retinol is reduced; in addition, high concentrations of retinol may cause irritation to sensitive skin. Hexapeptide and snake venom peptide substances are high in price, low in content and unobvious in effect, have certain side effects, and can cause local nerve injury and local skin sensibility reduction after long-term and large-scale use, and can cause muscle paralysis in severe cases, can cause facial muscle stiffness and influence facial expression. Based on the above statements, it can be seen that although the prior art wrinkle resistant products are diverse, there are few truly safe and effective products.
Disclosure of Invention
Aiming at the defects in the prior art, the application provides a collagen-containing skin anti-wrinkle composition, an anti-wrinkle product and a preparation method thereof, wherein the anti-wrinkle composition has obvious effects of anti-wrinkle, skin repair, barrier enhancement, water supplementing, moisture preservation, pore shrinking and the like, and effectively solves the problems of the existing product.
In order to achieve the above purpose, the technical scheme adopted by the application for solving the technical problems is as follows:
a collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 0.5-2 parts of hydrolyzed sodium hyaluronate, 0.1-0.5 part of sodium hyaluronate, 0.2-1 part of collagen, 0.5-2 parts of ectoin, 2-4 parts of hirudin, 0.01-0.05 part of carnosine and 200 parts of water; wherein the collagen comprises macromolecular collagen and micromolecular collagen.
Further, 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1 part of ectoin, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water.
Further, the molecular weight of the hydrolyzed sodium hyaluronate is 0.5-1WDa, and the molecular weight of the sodium hyaluronate is 40-150W Da.
Further, the macromolecular collagen and the micromolecular collagen are recombinant type III collagen, the molecular weight of the macromolecular collagen is 4-5WDa, and the molecular weight of the micromolecular collagen is 3500-5000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the anti-wrinkle product being a concentrate, lotion or cream.
The preparation method of the anti-wrinkle product comprises the following steps:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin in water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving phospholipid in oil and fat to obtain phospholipid solution;
(4) Slowly dripping the first solution into a phospholipid solution to prepare a phospholipid microsphere solution;
(5) Mixing the phospholipid microsphere solution with the second solution under stirring, and packaging.
Further, the ratio of the water usage of the first solution to the second solution is 2-5:15-18.
Further, in the step (3), the grease is grape seed oil, avocado oil, shea butter or almond oil, the phospholipid is soybean lecithin or egg yolk phospholipid, and the mass ratio of the phospholipid to the grease is 1-2:1-2.
Further, in the step (4), the volume ratio of the first solution to the phospholipid solution is 1.5-3:1.
Further, the stirring speed is 300-500r/min, and the stirring time is 1-3min.
The beneficial effects of the application are as follows:
1. the composition is added with the ectoine, the collagen, the sodium hyaluronate and the hirudin, and the ectoine is a high-polarity molecule which has strong complexing ability with water molecules, so that the water molecules are arranged around the composition in a directional way, the spatial arrangement of the water molecules is changed, and the water loss is reduced; the elmendocin carrying water molecules tends to be distributed around proteins and cells, so that a hydration layer is formed outside the proteins and the cells by the water molecules, and damages of free radicals, active oxygen, ultraviolet rays and the like to the cells and the proteins are blocked; in addition, under the condition that the cells are in a high water environment, the metabolic activity of the cells is enhanced, more signal substances can be secreted to promote the regeneration of autologous collagen, so that the skin becomes more compact and full, and the generation of wrinkles is reduced; the sodium hyaluronate has extremely strong water absorption, can absorb more water, is used for complexing and arranging the ectoin, and has the combined action of the two, thereby improving the moisturizing, moisturizing and repairing effects;
collagen belongs to protein substances, micromolecular collagen can permeate into the skin, macromolecular collagen stays on the surface layer of the skin, the collagen is used as a positioning structure, the characteristics that the ectoin can directionally surround the collagen to be distributed, and the water molecules can surround the ectoin to be distributed are utilized, so that the water content of the surface layer and the deep layer of the skin is increased, the moisture content of the surface layer of the skin is increased, the moisturizing effect can be improved, the barrier effect of the skin can be enhanced, the influence of external factors on the skin is reduced, and the generation of free radicals and active oxygen is reduced; the moisture on the surface layer of the skin is increased, so that the cuticle can be softened, the metabolism of the cuticle can be accelerated, the skin state can be improved, and the purposes of shrinking pores, brightening skin color and relieving are achieved. The water content in the skin is increased, so that metabolism of the skin can be accelerated, and skin cell renewal can be promoted; the purpose of using two kinds of sodium hyaluronate with different molecular weights is to supplement water at different parts of skin, sodium hyaluronate mainly acts on the surface layer of skin, hydrolyzed sodium hyaluronate mainly acts on the deep layer of skin and is matched with the acting part of collagen, and a large amount of water is absorbed by the sodium hyaluronate and hydrolyzed sodium hyaluronate to supplement enough water for the part distributed by the collagen, so that the protective effect on the collagen and cells is improved, and the soothing effect is further improved;
the hirudin is a substance with smaller molecular weight, can permeate into the dermis layer through the skin surface layer, is usually used as an anticoagulation component, can increase metabolism of skin tissues, improve symptoms such as dark yellow skin, color spots and the like, promotes autologous collagen production after the metabolism is enhanced, combines the effects of collagen, ectoin and sodium hyaluronate, and can obviously improve the problems such as wrinkles, dry lines, dark yellow skin and the like of the skin after long-term use.
2. When the product is prepared, small molecular collagen, hydrolyzed sodium hyaluronate, ectoin and hirudin are dissolved in water to prepare a first solution, and then the first solution is wrapped in phospholipid to form phospholipid microspheres which are dispersed in grease; dissolving macromolecular collagen, sodium hyaluronate and carnosine in water to prepare a second solution, and directly mixing the grease containing phospholipid microspheres with the second solution when the prepared product is essence; when the prepared product is emulsion or facial cream, adding a proper amount of emulsifying agent into the emulsion to emulsify the emulsion; when in use, because the components of the phospholipid with cell membranes are almost the same, the phospholipid and the skin surface layer have better compatibility, and the phospholipid microspheres are fused with cells after being contacted with the cells, so that micromolecular collagen, hydrolyzed sodium hyaluronate, ectoin, hirudin and the like contained in the phospholipid microspheres penetrate into the deep layer of the skin preferentially, and the action effect is improved; the macromolecular collagen, sodium hyaluronate and other components of the solution act on the skin after permeation of other components and act on the surface layer of the skin, and by adopting the method, the permeability of the small molecular components can be improved, the situation that the macromolecular components act on the surface layer of the skin preferentially to block permeation channels and obstruct permeation of the small molecular components is avoided, and the overall acting effect is further improved.
3. Carnosine can be actively combined with redundant sugar, so that collagen in skin is prevented from being saccharified, and the carnosine has certain effects of resisting sugar and scavenging free radicals; meanwhile, the carnosine is alkaline, can be used as an acid-base regulator while playing a role, replaces the conventional sodium hydroxide, and regulates the pH value of the solution, so that the prepared skin care product is 5.0-7.0, the comfort of the product when the product acts on the skin is improved, and the phenomenon of allergy of a patient is avoided.
Detailed Description
The present application will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present application more apparent. It should be understood that the particular embodiments described herein are illustrative only and are not intended to limit the application, i.e., the embodiments described are merely some, but not all, of the embodiments of the application.
Thus, the following detailed description of the embodiments of the application, as provided, is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to be within the scope of the present application.
It is noted that relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises an element.
Example 1
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1 part of ectoin, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 80WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 4000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Example 2
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 0.8 part of hydrolyzed sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 0.8 part of ectoin, 2 parts of hirudin, 0.02 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.5WDa, the molecular weight of the sodium hyaluronate is 40WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 3500Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin in 20 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in avocado oil, wherein the mass ratio of the soybean lecithin to the avocado oil is 2:1, preparing phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 1.5:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 300r/min for 3min, and packaging.
Example 3
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 2 parts of hydrolyzed sodium hyaluronate, 0.5 part of sodium hyaluronate, 0.3 part of macromolecular collagen, 0.2 part of micromolecular collagen, 2 parts of ectoin, 4 parts of hirudin, 0.05 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 1WDa, the molecular weight of the sodium hyaluronate is 150WDa, the molecular weight of the macromolecular collagen is 5WDa, and the molecular weight of the micromolecular collagen is 5000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin 50 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) The yolk phospholipids are dissolved in the shea butter, and the mass ratio of the yolk phospholipids to the shea butter is 2:1, preparing phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 2:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 500r/min for 1min, and packaging.
Example 4
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1.5 parts of hydrolyzed sodium hyaluronate, 0.4 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.5 part of micromolecular collagen, 1.5 parts of ectoin, 3 parts of hirudin, 0.03 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.7 and WDa, the molecular weight of the sodium hyaluronate is 120 and WDa, the molecular weight of the macromolecular collagen is 5W Da, and the molecular weight of the micromolecular collagen is 4200Da.
An anti-wrinkle product comprising a collagen-containing dermatological anti-wrinkle composition, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin 40 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) The yolk phospholipids are dissolved in the almond oil, and the mass ratio of the yolk phospholipids to the almond oil is 1:2, preparing phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 2.5:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 350r/min for 2min, and packaging.
Example 5
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1.8 parts of hydrolyzed sodium hyaluronate, 0.4 part of sodium hyaluronate, 0.3 part of macromolecular collagen, 0.5 part of micromolecular collagen, 1.2 parts of ectoin, 2.5 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 100WDa, the molecular weight of the macromolecular collagen is 5W Da, and the molecular weight of the micromolecular collagen is 3500Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving yolk phospholipids into grape seed oil, wherein the mass ratio of the yolk phospholipids to the grape seed oil is 2:2, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Example 6
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 0.8 part of hydrolyzed sodium hyaluronate, 0.4 part of sodium hyaluronate, 0.6 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1.5 parts of ectoin, 4 parts of hirudin, 0.05 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 1WDa, the molecular weight of the sodium hyaluronate is 130WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 4200Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin in 35 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving yolk phospholipids into avocado oil, wherein the mass ratio of yolk phospholipids to avocado oil is 1:1, and preparing phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 2:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 3min, and packaging.
Comparative example 1
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1 part of ectoin, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the sodium hyaluronate is 80WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 4000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving small molecular collagen, hirudin and ectoin in 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Comparative example 2
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 1 part of ectoin, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 80WDa, and the molecular weight of the macromolecular collagen is 4W Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, hirudin and ectoin 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Comparative example 3
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 80WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 4000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen and hirudin in 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Comparative example 4
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1 part of ectoin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 80WDa, the molecular weight of the macromolecular collagen is 4W Da, and the molecular weight of the micromolecular collagen is 4000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen and ectoin in 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Comparative example 5
A collagen-containing dermatological anti-wrinkle composition comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of micromolecular collagen, 1 part of ectoin, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water; wherein, the molecular weight of the hydrolyzed sodium hyaluronate is 0.8WDa, the molecular weight of the sodium hyaluronate is 80WDa, and the molecular weight of the small molecular collagen is 4000Da.
An anti-wrinkle product comprising the collagen-containing dermatological anti-wrinkle composition described above, the method of making comprising:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin 30 parts of water to prepare a first solution;
(2) Dissolving sodium hyaluronate and carnosine in the residual water to prepare a second solution;
(3) Dissolving soybean lecithin in grape seed oil, wherein the mass ratio of the soybean lecithin to the grape seed oil is 1:1, and preparing a phospholipid solution;
(4) Slowly dripping the first solution into the phospholipid solution, wherein the volume ratio of the first solution to the phospholipid solution is 3:1, and preparing a phospholipid microsphere solution;
(5) Mixing phospholipid microsphere solution and the second solution under stirring at 400r/min for 2min, and packaging.
Experimental example
120 facial skin is recruited, and the water loss is more than or equal to 15g/m 2 h and lactic acid stinging positive volunteers used the products of example 1 and comparative examples 1-5 periodically as required, and at the set time point, by the method of instrumental test, TEWL values, heme, a-value, wrinkle count (canthus lines, stature lines), wrinkle area ratio (canthus lines, stature lines), wrinkle length (canthus lines, stature lines), skin firmness F4, skin elasticity R2 of the tested parts were measured before using the products, after using the products for 14 days, after using the products for 28 days, and product repairing, soothing, anti-wrinkle, compactness efficacy was evaluated according to the values, and whether the products were suitable for the sensitive muscle group was evaluated.
(1) Volunteer conditions:
1. age between 18-45 years (except pregnant or lactating women);
2. the basic value of the percutaneous water loss of the facial skin is 15g/m 2 And (3) scoring the lactic acid stinging score for more than 3, and investigating the subjective facial skin questionnaire as sensitive skin.
3. Sebum secretion affecting formulations were not used in the last month.
4. No antihistamine was used for the last week or no immunosuppressant was used during the last month;
5. not those with inflammatory skin diseases that are clinically unhealed;
6. not insulin dependent diabetics;
7. patients with asthma or other chronic respiratory diseases who are not undergoing treatment;
8. patients receiving anti-cancer chemotherapy are not received in nearly six months;
9. patients who are not immunodeficiency or autoimmune disease;
11. not bilateral mastectomy and bilateral axillary lymphadenectomy patients;
11. the test part is not affected by scar, pigment, atrophy, mole, or other flaws;
12. is not a highly sensitive person;
13. no other clinical trial study was engaged.
(2) Limiting matters
During the test, hot water and spicy food were prohibited from being consumed;
during the test, frequent access to the constant temperature and humidity room is forbidden;
during the test, shielding the touch test part in the test process is forbidden.
(3) Experimental instrument
MPA10 Multi-Probe test System (Coura & Khazaka, germany): tewameter test probe, skin-Colorimeter test probe, mexameter test probe, corneometer CM test probe, TM Hex probe.
(4) Test environment
Temperature: 210 ℃ +/-1.0 ℃; humidity: 50% ± 10%, and performing real-time dynamic monitoring.
(5) Test procedure
Table 1: test procedure
(6) Adverse events
The classification of the skin adverse reaction is judged according to the classification standard of the skin adverse reaction in the human trial safety evaluation specified in the 2015 edition of the cosmetic safety technical Specification:
table 2: adverse reaction decomposition table
(7) Experimental results
Table 3: subject's skin heme Erythema value before and after use of test sample
Table 4: TEWL value (g/m) of percutaneous moisture loss before and after using test sample 2 h）
Table 5: subject skin elasticity R2 before and after use of test sample
Table 6: subject skin firmness before and after use of test sample F4
Table 7: skin color a values before and after use of the test sample by the subject
Table 8: subject use of test sample for anterior and posterior eye angular pattern conditions
Table 9: subject's pre-and post-use french conditions with test sample
Table 10: adverse reaction conditions
As can be seen from the results in tables 3-7, the test products of example 1 were used to demonstrate the efficacy of repair, relaxation, and tightening in that the test products of examples 1 were used to demonstrate the variations in TEWL, heme, a, skin firmness F4, and skin elasticity R2 that were all greater than the test products of comparative examples 1-5.
As can be seen from the results in tables 8 to 9, the test products of example 1 were used to test the test products for the presence of a reduced number of canthus lines and french lines, a reduced canthus line area ratio and a reduced canthus line and french line length, and a greater rate of change than the test products of comparative examples 1 to 5, and further demonstrated that the products of the present application had anti-wrinkle effects.
In comparative examples 1 to 5, the effects of hyaluronic acid, small molecular collagen, ectoin, hirudin and macromolecular collagen, which are hydrolyzed, are respectively canceled, and after canceling the above components, the effects of repairing, relieving, tightening, anti-wrinkle and the like of the product are all deteriorated, and analysis shows that each component in the composition has an interaction relationship, and after canceling a certain component, the interaction with other components is lost, thereby causing the effect of the product to be deteriorated.
As can be seen from the results in Table 10, the test persons did not show any adverse reaction after using the products of example 1 and comparative examples 1 to 5, demonstrating that the product of the present application was used for the skin allergy test, and the skin allergy problem was not caused.
Claims (10)
1. A collagen-containing dermatological anti-wrinkle composition, comprising the following components in parts by weight: 0.5-2 parts of hydrolyzed sodium hyaluronate, 0.1-0.5 part of sodium hyaluronate, 0.2-1 part of collagen, 0.5-2 parts of ectoin, 2-4 parts of hirudin, 0.01-0.05 part of carnosine and 200 parts of water; wherein the collagen comprises macromolecular collagen and micromolecular collagen.
2. The collagen-containing dermatological anti-wrinkle composition according to claim 1, comprising the following components in parts by weight: 1 part of hydrolyzed sodium hyaluronate, 0.3 part of sodium hyaluronate, 0.2 part of macromolecular collagen, 0.2 part of micromolecular collagen, 1 part of ectoine, 3 parts of hirudin, 0.04 part of carnosine and 200 parts of water.
3. Collagen-containing dermatological anti-wrinkle composition according to claim 1 or 2, wherein the hydrolyzed sodium hyaluronate has a molecular weight of 0.5-1WDa and the sodium hyaluronate has a molecular weight of 40-150W Da.
4. The collagen-containing dermatological anti-wrinkle composition according to claim 2, wherein the macromolecular collagen and the small molecular collagen are recombinant type III collagen, the molecular weight of the macromolecular collagen is 4-5W Da, and the molecular weight of the small molecular collagen is 3500-5000Da.
5. An anti-wrinkle product comprising a collagen-containing dermatological anti-wrinkle composition according to any one of claims 1-4, wherein the anti-wrinkle product is a concentrate, an emulsion or a cream.
6. The method for producing an anti-wrinkle product according to claim 5, comprising the steps of:
(1) Dissolving hydrolyzed sodium hyaluronate, small molecular collagen, hirudin and ectoin in water to prepare a first solution;
(2) Dissolving sodium hyaluronate, macromolecular collagen and carnosine in the residual water to prepare a second solution;
(3) Dissolving phospholipid in oil and fat to obtain phospholipid solution;
(4) Slowly dripping the first solution into a phospholipid solution to prepare a phospholipid microsphere solution;
(5) Mixing the phospholipid microsphere solution with the second solution under stirring, and packaging.
7. The method of producing an anti-wrinkle product according to claim 6, wherein the ratio of the water usage in the first solution to that in the second solution is 2-5:15-18.
8. The method of producing anti-wrinkle product according to claim 6, wherein the fat in step (3) is grapeseed oil, avocado oil, shea butter or almond oil, the phospholipid is soybean lecithin or egg yolk phospholipid, and the mass ratio of the phospholipid to the fat is 1-2:1-2.
9. The method of producing an anti-wrinkle product according to claim 6, wherein the volume ratio of the first solution to the phospholipid solution in step (4) is 1.5-3:1.
10. The method for producing an anti-wrinkle product according to claim 6, wherein the stirring speed is 300-500r/min and the stirring time is 1-3min.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
| CN117618321A (en) * | 2024-01-24 | 2024-03-01 | 成都普什制药有限公司 | Moisturizing and repairing essence and preparation method thereof |
| CN118286100A (en) * | 2024-06-04 | 2024-07-05 | 广州伊尔美生物科技有限公司 | III type collagen anti-wrinkle cream and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688158A (en) * | 2012-06-06 | 2012-09-26 | 广州舒泰生物技术有限公司 | Additive-free anti-aging cosmetic and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688158A (en) * | 2012-06-06 | 2012-09-26 | 广州舒泰生物技术有限公司 | Additive-free anti-aging cosmetic and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
| CN117618321A (en) * | 2024-01-24 | 2024-03-01 | 成都普什制药有限公司 | Moisturizing and repairing essence and preparation method thereof |
| CN118286100A (en) * | 2024-06-04 | 2024-07-05 | 广州伊尔美生物科技有限公司 | III type collagen anti-wrinkle cream and preparation method thereof |
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