CN112438904A - Moisturizing mask liquid containing glycerol glucoside and preparation method thereof - Google Patents
Moisturizing mask liquid containing glycerol glucoside and preparation method thereof Download PDFInfo
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- CN112438904A CN112438904A CN202011505232.4A CN202011505232A CN112438904A CN 112438904 A CN112438904 A CN 112438904A CN 202011505232 A CN202011505232 A CN 202011505232A CN 112438904 A CN112438904 A CN 112438904A
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- moisturizing
- glycerol glucoside
- mask liquid
- glycerol
- humectant
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims abstract description 87
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 40
- 229930182478 glucoside Natural products 0.000 title claims abstract description 36
- -1 glycerol glucoside Chemical class 0.000 title claims abstract description 36
- 239000007788 liquid Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000003906 humectant Substances 0.000 claims abstract description 22
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 16
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 16
- 239000002562 thickening agent Substances 0.000 claims abstract description 16
- 239000000047 product Substances 0.000 claims abstract description 15
- 239000004902 Softening Agent Substances 0.000 claims abstract description 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 11
- 238000000855 fermentation Methods 0.000 claims abstract description 11
- 230000004151 fermentation Effects 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000011159 matrix material Substances 0.000 claims abstract description 6
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 20
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 20
- 230000001815 facial effect Effects 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 10
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 10
- 229940032094 squalane Drugs 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 239000003974 emollient agent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 7
- 229960000281 trometamol Drugs 0.000 claims description 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 5
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 5
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 229940101267 panthenol Drugs 0.000 claims description 5
- 235000020957 pantothenol Nutrition 0.000 claims description 5
- 239000011619 pantothenol Substances 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract description 6
- 229940010747 sodium hyaluronate Drugs 0.000 abstract description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002421 anti-septic effect Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 19
- 238000012360 testing method Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 210000000245 forearm Anatomy 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 208000026935 allergic disease Diseases 0.000 description 3
- ZAFJDLVZVINKSX-UHFFFAOYSA-N azane butane-1,1,1-triol Chemical compound N.CCCC(O)(O)O ZAFJDLVZVINKSX-UHFFFAOYSA-N 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000010637 Aquaporins Human genes 0.000 description 1
- 108010063290 Aquaporins Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102100028314 Filaggrin Human genes 0.000 description 1
- 101710088660 Filaggrin Proteins 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010050637 Skin tightness Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 description 1
- 229940093767 glabridin Drugs 0.000 description 1
- PMPYOYXFIHXBJI-ZDUSSCGKSA-N glabridin Natural products C1([C@H]2CC=3C=CC4=C(C=3OC2)CCC(O4)(C)C)=CC=C(O)C=C1O PMPYOYXFIHXBJI-ZDUSSCGKSA-N 0.000 description 1
- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000001521 two-tailed test Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a moisturizing mask liquid containing glycerol glucoside and a preparation method thereof, wherein the moisturizing mask liquid comprises 1-5% of glycerol glucoside by mass and the balance of a mask liquid matrix, and the mask liquid matrix comprises the following raw materials in percentage by weight: 0.08-0.15% of thickening agent, 6-15.85% of humectant, 1-2% of softening agent, 0.065-0.12% of acid-base regulator, 0.3-0.5% of antioxidant, and yeast fermentation product filtrate. The invention replaces the common moisturizing raw materials such as sodium hyaluronate and the like with the novel moisturizing agent glycerol glucoside, thereby enhancing the absorptivity and the use feeling and reducing the cost; the invention adopts an anhydrous and non-antiseptic formula, is safer to use and has more obvious effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an essence mainly containing glabridin and having an efficient whitening effect and a preparation method of the essence.
Background
The mark of aging left against the years is the lesson of the graduate of each woman. Day cream or night cream is a luxury thing in the past, but now the living standard of people is improved, and the consumption of the mask is increased sharply. Often, many women leave a work, wash the face with warm water, stick a facial mask, lie on a lounge chair, enjoy the relaxation between the minutes, also let your face beautify and repair and moisten, this is the work class after many women leave a work, also is one of the relaxation of work for the rest of a day. The moisturizing mask is a mask for moisturizing human skin, and is used for moisturizing and improving the skin state aiming at the adverse states of skin tightness, dryness, itching and the like. At present, sodium hyaluronate is adopted in most commercially available moisturizing facial masks, but the sodium hyaluronate has the disadvantages of complex process, high cost and poor use feeling.
Disclosure of Invention
The invention aims to provide moisturizing facial mask liquid containing glycerol glucoside and a preparation method thereof
The technical scheme adopted by the invention is as follows:
the moisturizing mask liquid containing the glycerol glucoside is characterized in that: the facial mask liquid comprises 1-5% of glycerol glucoside and the balance of a facial mask liquid matrix, wherein the facial mask liquid matrix comprises the following raw materials in percentage by weight: 0.08-0.15% of thickening agent, 6-15.85% of humectant, 1-2% of softening agent, 0.065-0.12% of acid-base regulator, 0.3-0.5% of antioxidant, and yeast fermentation product filtrate.
The humectant is a mixture of glycerol, butanediol, panthenol, trehalose, glycerol glucoside, 1, 2-hexanediol, and ethylhexylglycerin.
The thickening agent is carbomer, and the pH regulator is tromethamine.
The antioxidant is p-hydroxyacetophenone, and the emollient is a mixture of polyglycerol-10 stearate and squalane.
A preparation method of moisturizing facial mask liquid containing glycerol glucoside is characterized by comprising the following steps:
step 1: weighing humectant, yeast fermentation product filtrate and thickener, and stirring at 70-80 deg.C for dissolving;
step 2: cooling to 60-70 deg.C, adding tromethamine as acid-base regulator, and stirring;
and step 3: weighing the softening agents of polyglycerol-10 stearate and squalane, and independently dissolving at 60-70 ℃;
and 4, step 4: adding emollient, and homogenizing for 3-5 min;
and 5: adding humectant 1, 2-hexanediol, ethylhexyl glycerol and antioxidant p-hydroxyacetophenone, stirring to dissolve completely;
step 6: sampling, detecting, packaging and warehousing.
The invention has the advantages that: common moisturizing raw materials such as sodium hyaluronate and the like are replaced by the novel moisturizing agent glycerol glucoside, so that the absorptivity and the use feeling are enhanced, and the cost is reduced; the invention adopts an anhydrous and non-antiseptic formula, is safer to use and has more obvious effect.
Detailed Description
Example 1
The moisturizing mask liquid containing the glycerol glucoside is prepared from the following raw materials in percentage by weight: 7.75% of humectant (wherein glycerol glucoside is 1%), 0.08% of thickening agent, 0.065% of acid-base regulator, 0.3% of antioxidant, 1% of softening agent and the balance of yeast fermentation product filtrate to 100%.
Wherein the humectant is a mixture of glycerol, butanediol, panthenol, trehalose, glycerol glucoside, 1, 2-hexanediol and ethylhexylglycerin; the thickening agent is carbomer; the pH regulator is tromethamine; the antioxidant is p-hydroxyacetophenone; the softening agent is a mixture of polyglycerol-10 stearate and squalane.
The preparation method of the moisturizing facial mask liquid containing the glycerol glucoside comprises the following steps:
step 1: weighing humectant, yeast fermentation product filtrate and thickener, and stirring at 70 deg.C for dissolving;
step 2: cooling to 60 ℃, adding ammonia butanetriol serving as an acid-base regulator, and stirring uniformly;
and step 3: weighing the softening agents of polyglycerol-10 stearate and squalane, and independently dissolving at 60 ℃;
and 4, step 4: adding emollient, and homogenizing for 3 min;
and 5: adding humectant 1, 2-hexanediol, ethylhexyl glycerol and antioxidant p-hydroxyacetophenone, stirring to dissolve completely;
step 6: sampling, detecting, packaging and warehousing.
Example 2
The moisturizing mask liquid containing the glycerol glucoside is prepared from the following raw materials in percentage by weight: 14.3% of humectant (wherein the content of glycerol glucoside is 3%), 0.1% of thickening agent, 0.077% of acid-base regulator, 0.4% of antioxidant, 1.6% of softening agent and the balance of yeast fermentation product filtrate to 100%.
Wherein the humectant is a mixture of glycerol, butanediol, panthenol, trehalose, glycerol glucoside, 1, 2-hexanediol and ethylhexylglycerin; the thickening agent is carbomer; the pH regulator is tromethamine; the antioxidant is p-hydroxyacetophenone; the softening agent is a mixture of polyglycerol-10 stearate and squalane.
The preparation method of the moisturizing facial mask liquid containing the glycerol glucoside comprises the following steps:
step 1: weighing humectant, yeast fermentation product filtrate and thickener, and stirring at 80 deg.C for dissolving;
step 2: cooling to 70 ℃, adding ammonia butanetriol serving as an acid-base regulator, and stirring uniformly;
and step 3: weighing the softening agents of polyglycerol-10 stearate and squalane, and independently dissolving at 70 ℃;
and 4, step 4: adding emollient, and homogenizing for 5 min;
and 5: adding humectant 1, 2-hexanediol, ethylhexyl glycerol and antioxidant p-hydroxyacetophenone, stirring to dissolve completely;
step 6: sampling, detecting, packaging and warehousing.
Example 3
The moisturizing mask liquid containing the glycerol glucoside is prepared from the following raw materials in percentage by weight: 20.85% of humectant (wherein the content of glycerol glucoside is 5%), 0.13% of thickening agent, 0.1% of acid-base regulator, 0.5% of antioxidant, 2% of soft lubricant, and the balance of yeast fermentation product filtrate to 100%.
Wherein the humectant is a mixture of glycerol, butanediol, panthenol, trehalose, glycerol glucoside, 1, 2-hexanediol and ethylhexylglycerin; the thickening agent is carbomer; the pH regulator is tromethamine; the antioxidant is p-hydroxyacetophenone; the softening agent is a mixture of polyglycerol-10 stearate and squalane.
The preparation method of the moisturizing facial mask liquid containing the glycerol glucoside comprises the following steps:
step 1: weighing humectant, yeast fermentation product filtrate and thickener, and stirring at 75 deg.C for dissolving;
step 2: cooling to 65 ℃, adding ammonia butanetriol serving as an acid-base regulator, and stirring uniformly;
and step 3: weighing the softening agents of polyglycerol-10 stearate and squalane, and independently dissolving at 65 ℃;
and 4, step 4: adding emollient, and homogenizing for 4 min;
and 5: adding humectant 1, 2-hexanediol, ethylhexyl glycerol and antioxidant p-hydroxyacetophenone, stirring to dissolve completely;
step 6: sampling, detecting, packaging and warehousing.
The invention replaces the common moisturizing raw materials such as sodium hyaluronate and the like with the novel moisturizing agent glycerol glucoside, thereby enhancing the absorptivity and the use feeling and reducing the cost; the invention adopts an anhydrous and non-antiseptic formula, is safer to use and has more obvious effect.
The moisture retention efficacy evaluation of the invention:
first, experimental material
The instrument comprises the following steps: cornemeter CMB25 (Germany CK company)
And (3) testing a sample: example 1, example 2, and example 3
II, experimental conditions: indoor environment, no strong sunlight or direct light, environment temperature of 20 +/-2 ℃ and environment humidity of 40-60%.
Third, subject Condition
1. The subjects with age of 18-60 years are all male and female, and female takes precedence
2. Patients without severe systemic disease, immunodeficiency or autoimmune disease
3. Patients with inactive allergic diseases
4. Has no history of allergy to skin care cosmetics
5. Hormone medicine and immunosuppressant have not been used in the last month
6. Those who did not participate in other clinical trials
7. Volunteer participator capable of completing specified contents according to experiment requirements
Fourth, the working principle of the moisture content of the skin
The moisture content of the skin can be measured by adopting a worldwide accepted Cornemeter-capacitance method, the principle of which is based on that the dielectric constant (< 7) of water (81) and other substances is changed greatly, and a properly-shaped measuring capacitor changes along with the change of the capacitance of the skin according to the difference of water content, and the capacitance of the skin is in a measuring range. The capacitance measuring method is superior to other methods in that the test result is practically not affected by polarization effect and ionic conductivity since the skin to be tested is not in unnatural contact with the test probe and almost no current flows through the skin to be tested. The instrument probe and the water in the skin have no inertia in the process of establishing balance, and can realize quick measurement, thereby eliminating the influence of active skin on the measurement result.
Fifth, testing step
1. Test area: the inner side of the forearm;
2. preparation before testing: the whitening effect products (cosmetics, external medicines or internal health products) cannot be used 2-3 days before the tested part, the testee needs to uniformly clean the inner side of the forearm before the test, the forearm is wiped clean by dry facial tissue, the measuring area mark is made on the inner side of the forearm of the testee after the cleaning, the testee needs to sit still for at least 30min in a room meeting the standard before formal test, the forearm is exposed and placed in a testing state to keep relaxed.
3. In the experiment, the inner forearm is marked with 5X 4cm2 experimental area, and the same arm can mark multiple areas at the same time, and the areas are spaced by 2 cm. The test products and the blank control are randomly distributed on the forearm, the blank value of 30min after cleaning of each test area is firstly measured, then the test sample is uniformly coated in the experimental area by using a latex finger cot according to the dosage of 2.0 +/-0.1 mg sample/cm 2, and the skin moisture content of the test area and the control area is respectively measured after the test sample and the control area are coated for 0.5h, 1.0h, 1.5h, 2.0h, 4.0h, 6.0 h. The measurements of the same volunteer were performed by the same measurement staff.
Sixthly, measuring indexes: skin moisture content determination: the measurement was performed 3 times, and the average value was taken.
Seventhly, comparison form: different treatment controls were performed using the same.
Eighthly, a statistical method comprises the following steps: and performing pairing t test.
Results and analysis
The results of the measurements of the participating test persons are shown in table 1:
table 1;
and (3) analysis: a moisturizing mask solution containing glycerol glucoside example 1/2/3 was evaluated for skin moisturizing efficacy after 6 hours of use, and volunteers did not experience adverse reactions such as allergy during use.
After trial for 6h, the experimental data is analyzed as shown in table 2, the two-tailed test, t0.05 (3) =3.182
Table 2;
through statistical analysis, after the samples are used for 0.5h, 1h, 1.5h, 2h, 4h and 6h, the moisturizing mask liquid containing the glycerol glucoside in the embodiment 1/2/3 has the moisturizing effect, and the moisturizing time is 6 h.
The difference has statistical significance, and the embodiment 1/2/3 of the moisturizing mask liquid containing the glycerol glucoside has the moisturizing effect, and the moisturizing time is 6 hours.
And (3) analysis and summary: a moisturizing facial mask liquid containing glycerol glucoside has moisturizing effect.
Skin water deficiency can cause the appearance of dryness, yellowing, dullness, laxity, wrinkles, aging, etc., and adult women have skin water content of only 15% or less, far below 25% of that of infants, and water deficiency is the root cause of skin aging. But merely moisturizing does not solve the skin problem, and water locking and moisturizing are also important. The moisture retention is to prevent the evaporation of the moisture of the skin, moisten the skin, improve the microcirculation and enhance the moisture of the skin. The common humectant such as sodium hyaluronate has the defects of complex process, high cost, poor use feeling and the like. The glycerol glucoside is from plants, is safe and low in risk, does not affect the final use feeling of products, and most importantly, can stimulate the expression of filaggrin mRNA, promote the synthesis of aquaporin and bring more required water to skin cells.
The above-mentioned embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements made to the technical solution of the present invention by those skilled in the art without departing from the spirit of the present invention should be included in the protection scope defined by the claims of the present invention.
Claims (5)
1. The moisturizing mask liquid containing the glycerol glucoside is characterized in that: the facial mask liquid comprises 1-5% of glycerol glucoside and the balance of a facial mask liquid matrix, wherein the facial mask liquid matrix comprises the following raw materials in percentage by weight: 0.08-0.15% of thickening agent, 6-15.85% of humectant, 1-2% of softening agent, 0.065-0.12% of acid-base regulator, 0.3-0.5% of antioxidant, and yeast fermentation product filtrate.
2. The moisturizing mask solution containing the glycerol glucoside according to claim 1, wherein: the humectant is a mixture of glycerol, butanediol, panthenol, trehalose, glycerol glucoside, 1, 2-hexanediol, and ethylhexylglycerin.
3. The moisturizing mask solution containing the glycerol glucoside according to claim 1, wherein: the thickening agent is carbomer, and the pH regulator is tromethamine.
4. The moisturizing mask solution containing the glycerol glucoside according to claim 1, wherein: the antioxidant is p-hydroxyacetophenone, and the emollient is a mixture of polyglycerol-10 stearate and squalane.
5. The method for preparing moisturizing mask solution containing glycerol glucoside according to claim 1, comprising the following steps:
step 1: weighing humectant, yeast fermentation product filtrate and thickener, and stirring at 70-80 deg.C for dissolving;
step 2: cooling to 60-70 deg.C, adding tromethamine as acid-base regulator, and stirring;
and step 3: weighing the softening agents of polyglycerol-10 stearate and squalane, and independently dissolving at 60-70 ℃;
and 4, step 4: adding emollient, and homogenizing for 3-5 min;
and 5: adding humectant 1, 2-hexanediol, ethylhexyl glycerol and antioxidant p-hydroxyacetophenone, stirring to dissolve completely;
step 6: sampling, detecting, packaging and warehousing.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110680771A (en) * | 2019-10-24 | 2020-01-14 | 凡其生物科技(北京)有限公司 | A composition containing Fucus vesiculosus extract and glycerol glucoside |
| CN111759792A (en) * | 2020-06-30 | 2020-10-13 | 广州市科能化妆品科研有限公司 | Preservative-free moisturizing mask liquid and preparation method thereof |
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2020
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110680771A (en) * | 2019-10-24 | 2020-01-14 | 凡其生物科技(北京)有限公司 | A composition containing Fucus vesiculosus extract and glycerol glucoside |
| CN111759792A (en) * | 2020-06-30 | 2020-10-13 | 广州市科能化妆品科研有限公司 | Preservative-free moisturizing mask liquid and preparation method thereof |
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| Title |
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| 现代百朗德生物科技（江苏）有限公司: "The Bio Mask玻尿酸保湿红茶菌发酵面膜 备案编号：苏G妆网备字2020004430", 《国产非特殊用途化妆品备案服务平台》 * |
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