KR20070096163A - Composition for atopy skin - Google Patents

Abstract

A composition for atopy skin is provided to alleviate or treat atopy skin disease, and improve coarse and dry skin state when it is applied to the specific skin region where a horny layer is easily formed without side effects. A composition for atopy skin comprises 80-98 wt.% of horse oil, 0.5-20 wt.% of Chamaecyparis Obtusa oil, 0.5-1.2 wt.% of lactic acid bacterium-fermented product, 0.01-0.02 wt.% of lactic acid bacteria, 0.5-0.9 wt.% of octyldodecanol, and 0.04-0.06 wt.% of stearyl glycyrrhetinate, wherein the lactic acid bacterium-fermented product contains the product produced by lactic acid bacteria of a plant selected from mugwort, mushroom, spinach, olive, laurel leaf, sea tangle, brown seaweed, plantain, Houttuyniae Herba, Agaricus blazei murrill, fig, tangerine, orange, mulberry fruit, clematis, blueberry or plum.

Description

Composition for atopy skin

The present invention relates to atopic dermatological compositions, and more particularly, to atopic dermatitis, which can relieve or alleviate each step of skin drying, itching, inflammation, microbial infection, etc., which are the main clinical aspects of atopic dermatitis by applying to the skin. It relates to a composition.

Atopic dermatitis is a recurrent chronic dermatitis with severe pruritus and its cause has not been clearly identified to date, but it is estimated that 10 to 20% of the world's population suffers from this dermatitis. In addition, the prevalence of atopic dermatitis continues to rise in recent decades due to an increase in the cause of airborne allergens due to environmental pollution and the increase of conditions for forming dry skin. The number is on the rise.

The term atopy has a dictionary meaning of a clinical hypersensitivity or allergy, meaning 'weird' or 'inappropriate'. People with atopic dermatitis are well known for their urticaria response to a number of antigens when they are tested for protein antigens such as house dust, mites, animal hair, pollen, and foods. Anaphylactic shock, urticaria and angioedema, wheezing and shortness of breath, nasal congestion, runny nose, sneezing, conjunctival redness and swelling, vomiting, diarrhea and abdominal pain when the body is exposed to the body in minutes or hours. The immediate response of the dorsal to the skin, respiratory, eye and intestinal mucosa well, and this strange and inappropriate response is characterized by a family appearance.

Clinically, atopic dermatitis has a characteristic skin lesion and distribution according to the age of the patient. It can be divided into three stages: infancy, childhood, puberty and adulthood. In infants from 2 months to 3 months to 2 years of age when atopic dermatitis begins, symptoms of atopic dermatitis appear red, moist, oily, and crusty on the head, face, and trunk. .

Conventionally, atopic dermatitis was considered to be a kind of allergy, but as the consideration on the non-allergic side expands, it is approaching the cause and solution of the eczema reaction. In the process of reviewing the patients with various skin physiological functions, it shows abnormal function such as decreased sweating, decreased sebum secretion, abnormal skin vascular response, and dry skin. Composition A new view suggests that skin has the most significant significance as a condition of atopic dermatitis.

When dry skin is formed, the protective function of the surface of the skin is lost, and it is easy to infiltrate the skin from allergens or allergens, and the skin reacts to such invasion. The rejection of the skin is manifested as an inflammatory phenomenon caused by the cytokines produced and released by keratinocytes, which constitute the majority of the surface components, by activating a small number of langerhans, melanocytes, and the like. The cytokines act to attract inflammatory cells, and in particular, activate the constituent cells of the skin to cause an inflammatory response centered on the upper skin layer and form an eczema reaction, which is called non-allergic skin disease.

Atopic rhinitis as described above is a disease that has a high risk of recurrence and requires special skin care.

To this end, various types of skin compositions have been developed in the past. However, there are limitations to effectively alleviate the atopic dermatitis, as well as consisting mainly of chemicals as the main ingredient. In addition, atopic dermatological compositions using various natural products have been developed, but incompleteness still exists in terms of effects or skin application.

The present invention is to take into consideration the incompleteness of the conventional atopic dermatitis-related composition as described above, and provides a composition for atopic dermatitis that can protect and prevent atopic skin and alleviate the symptoms of atopic dermatitis.

Atopic dermatitis composition according to the present invention horse oil (horse oil) 80 to 98% by weight, cypress essential oil 0.5 to 20% by weight, lactic acid bacteria fermentation 0.5 to 1.2% by weight, lactic acid bacteria 0.01 to 0.02% by weight, octyldodecanol (octyldodecanol) 0.5 to 0.9 weight percent, and 0.04 to 0.06 weight percent stearyl glycyrrhetinate.

The lactic acid bacteria fermentation is at least one plant selected from the group consisting of wormwood, mushrooms, spinach, olives, bay leaf, kelp, seaweed, plantain, eoseongcho, agaricus, fig, citrus, orange, mulberry fruit, vine, blueberry and plum Contains fermented products by lactic acid bacteria.

The lactic acid bacteria fermentation may be fermented by two or more kinds of lactic acid bacteria complex.

The atopic dermatological composition may further comprise 0.5 to 1.0% by weight of at least one hot water extract selected from the group consisting of aloe hot water extract and Echocho hot water extract.

As described above, the composition for atopic dermatitis may act on acne, dry skin, wounded skin as well as atopic dermatitis, thereby alleviating side effects according to the above symptoms. Furthermore, by using it steadily, it is possible to prevent the above symptoms and to provide an excellent moisturizing effect on the user's skin.

Hereinafter, the present invention will be described in detail.

Atopic dermatitis composition according to an aspect of the present invention comprises a natural oil component and lactic acid bacteria fermentation.

The atopic dermatological composition includes horse oil (horse oil) as the natural oil component. The horse oil is an animal oil and contains an excess of unsaturated fatty acids in addition to saturated fatty acids. In particular, the unsaturated fatty acid contains at least 60% alpha linolenic acid and linolenic acid. In addition, the horse oil has a chemical property very similar to the fatty acids of humans, so it has very good affinity and moisturizing properties.

If the amount of horse oil is less than 80% by weight, there is a problem that the skin penetration performance of the composition for atopic skin is lowered. In addition, when the amount of horse oil exceeds 98% by weight, the activity of other components is significantly lowered.

Therefore, the horse oil is 80 to 98% by weight, more preferably 96 to 98% by weight.

The horse oil can prevent the secondary bacterial infection through the skin by forming the oil film on the cell activity and regeneration of the skin.

In addition, the composition for atopic dermatitis contains a protein oil as a natural oil component.

The cypress essential oil is a volatile oil extracted from a hinoki tree native to Taiwan and Japan, and after extracting the hinoki for a long time under high temperature and high pressure steam, only essential oil components can be extracted by fractional distillation. The protein essential oil contains at least 2% hinocchiol. The hinochichiol has a high antibacterial effect that can inhibit the reproduction of various bacteria, such as Staphylococcus aureus and Escherichia coli.

If the content of the essential oil is less than 0.5% by weight, the antimicrobial effect is insufficient, while if the content of the essential oil is more than 20% by weight tends to weaken the activity of the lactic acid bacteria fermentation to be described later.

Therefore, the content of the essential oil is 0.5 to 20% by weight, preferably 0.5 to 2% by weight.

The protein essential oil has excellent bactericidal and antibacterial properties, and can relieve itching and wounds of the skin.

The lactic acid bacteria fermented product is a product obtained by fermenting vegetable materials such as vegetables or fruits using lactic acid bacteria. Plants used for the production of the fermentation, mugwort, mushrooms (matsuri, oyster), spinach, olives, laurel leaves, kelp, seaweed, plantain, seongchocho, agaricus, fig, tangerine, orange, mulberry fruit, vine, blue Berry, plum, etc. The plants may be used alone or in combination of two or more.

As lactic acid bacteria that can be used for the production of the lactic acid bacteria fermentation, Lactobacillus (Sactobacillus), Streptococcus (Streptococcus), Pediococcus (Pediococcus), Leukonostok (Leuconostoc) and the like. The lactic acid bacteria are morphologically divided into lactic acid bacillus (Lactobacillus genus) and lactic acid cocci (Streptococcus genus, Pedio coccus genus, Leukonostock genus). It can be classified into yeast fermentation bacteria to be produced, and heterofermentation bacteria to produce by-products (alcohol, carbon dioxide, etc.) in addition to lactic acid.

Lactic acid bacteria fermented product according to the present invention is preferably fermented with the hetero-fermentation bacteria.

In the present invention, the content of the lactic acid bacteria fermentation is preferably 0.5% to 1.2% by weight. The content of the lactic acid bacteria fermentation may vary depending on the type of lactic acid bacteria.

The composition for atopic dermatitis according to the present invention comprises lactic acid bacteria separately from lactic acid bacteria to produce lactic acid bacteria fermented products. The lactic acid bacteria to be added may be different from the lactic acid bacteria for production of the lactic acid bacteria fermentation product. In addition, the lactic acid bacteria may be used alone or two or more kinds of complex lactic acid bacteria may be used.

The lactic acid bacteria fermentation is preferably by a traditional fermentation method, preferably using a fermented product aged for one year or more. Fermentation method is as follows.

That is, in order to obtain the fermented lactic acid bacteria, various materials such as wormwood, mushrooms, figs, and blueberries are mixed and finely sliced, and then put into a reactor in a fermentor of water bath and stirred. The black (sulfur) sugar is added to the reactor while maintaining the temperature inside the fermenter at 20 to 45, and then stirred again. Then, inoculate the lactic acid bacteria strain to the lactic acid bacteria fermentation target in the reactor is engraft for about a week. After a certain period of time, the fermented product is extracted in units of 1 year, 3 years and 5 years after sealing in a porous container according to the traditional fermentation method. Or it can ferment under conditions using a constant temperature fermenter. The extraction period is the same as the traditional method.

In addition, the atopic dermatological composition comprises 0.5 to 0.9 wt% of octyldodecanol, and 0.04 to 0.06 wt% of stearyl glycyrrhetinate.

The atopic dermatitis composition may further comprise a hydrothermal extract of the functional plant. Examples of the hot water extract include aloe, fish cake, and the like. The functional plants may be used alone or in combination of two or more.

The hot water extract is preferably included to have a content of 0.5 to 1.0% by weight.

Although not described herein, the composition for atopic dermatitis according to the present invention may further include natural ingredients or chemical ingredients capable of performing specific functions.

Hereinafter, the present invention will be described in detail with reference to Examples. However, the technical spirit of the present invention is not limited by the following examples.

Example

Example 1

Lactobacillus Fermented product  Produce

For quick implementation, this example used a general fermentation method instead of the traditional method.

As the sample to be fermented, mugwort, mushroom, spinach, olive, bay leaf, kelp, seaweed, plantain, eoseongcho, agaricus, fig, citrus, orange, mulberry fruit, vine, blueberry and plum were used.

Each sample was dried and then ground. Each of the pulverized samples was added to distilled water and immersed for about 4 hours and then sterilized in a sterilization pot at 110 ° C. Lactobacillus Lactobacillus acidophilus and Lactobacillus bularicus were inoculated 1% in each sterilized sample and incubated for about one day. Each fermentation cultured during the day was lyophilized.

The lyophilized fermentations were centrifuged and the centrifuged fractions were concentrated.

Example 2

Preparation of atopic dermatological composition (1)

Using the concentrated fermentation (mugwort, fig) prepared in Example 1 to prepare a composition for atopic skin.

First, lactic acid bacteria fermented product, lactic acid bacteria, octyldodecanol and stearyl glycyrrhetinate were added to horse oil to prepare the atopic dermatological composition, followed by stirring sufficiently. A cypress essential oil (Aomori hiba) was added to the stirred mixture, followed by further mixing and stirring.

The final product, the composition for atopic dermatitis, was a cream type composition with some viscosity.

The composition of the atopy skin composition prepared in this example is shown in Table 1 below.

Example 3

Preparation of Atopy Skin Composition (2)

The atopic dermatological composition according to the present embodiment is the same in terms of components as the atopy composition of Example 2, except that the composition further comprises a hydrothermal extract.

In this example, hot water extracts of aloe and fish vinegar were further added to horse oil.

The hot water extract was cut into aloe and eoseongcho cut into pieces of a predetermined size and then extracted with hot water using 100 ℃ water.

The composition of the atopy skin composition prepared in this example is shown in Table 1 below.

ingredient Content (% by weight) Example 2 Example 3 Horse oil 80 80 Cypress Essential Oil 18.23 17.23 Lactobacillus fermented product Mugwort fermentation 0.5 0.5 Fig Ferment 0.5 0.5 Lactobacillus Lactobacillus ashdophyllus 0.01 0.01 Lactobacillus Bulgaricus 0.01 0.01          Octyldodecanol 0.7 0.7 Stearyl glycyrrhetinate 0.05 0.05 Hot Water Extract (Aloe / Echo) 1.0

Example 4

Panel Test (1)

-The 14-year-old man (A) and 12-year-old woman (B) who had acne were asked to apply the composition for atopic dermatitis prepared in Example 2 after washing for 2 weeks before bedtime and evaluating the improvement of symptoms.

-The 14-year-old man (A) and 12-year-old woman (B) who had acne were asked to apply the composition for atopy skin prepared in Example 3 after washing for 2 weeks before bedtime and evaluating the improvement of symptoms.

-Three-year-old man (C) with severe atopic symptoms on both arms was asked to apply the atopic dermatological composition prepared in Example 2 for two weeks and the degree of improvement of symptoms was evaluated.

-Three-year-old man (C) with severe atopic symptoms on both arms was asked to apply the composition for atopic skin prepared in Example 3 for two weeks and the degree of improvement of symptoms was evaluated.

-Adult female (D) who had severe itching, red spots, and skin peeling due to both hands due to the pharmaceutic drug was applied to the atopy skin composition prepared in Example 2 for one week, and the degree of improvement of symptoms was evaluated.

-Adult women (D) who had severe itching and red spots and skin peeling due to pharmaceutics were asked to apply the atopic dermatological composition prepared in Example 3 for 1 week and the degree of improvement of symptoms was evaluated.

The adult man (E) with exfoliated keratin and severe itching on the leg and waist side was asked to apply the composition for atopy skin prepared in Example 2 for 1 week and the degree of improvement of symptoms was evaluated.

The adult man (E) with exfoliated keratin and severe itching on the leg and waist side was asked to apply the atopy skin composition prepared in Example 3 for 1 week and the degree of improvement of symptoms was evaluated.

The evaluation results are shown in Table 2 below.

object Example 1 Example 2 A 4 4 B 4 4 C 5 5 D 4 5 E 3 4

* 5: Almost cure / 4: Very good / 3: Good / 2: No change / 1: Deterioration of symptoms

Example 5

Panel Test (2)

Five adolescent men and women without special skin diseases were treated with the atopic dermatitis skin composition of Example 2 for two weeks, and two weeks later, the skin condition (softness / moisturizing effect) of the atopic dermatological composition (right elbow) was evaluated. It was made.

Similarly, each of five adult men and women were subjected to atopic dermatitis composition of Example 3 for two weeks, and two weeks later, the skin condition (softness / moisturizing effect) of the atopic dermatological composition (left elbow) was evaluated. .

The results are expressed as the average rating of 10 people in total. Specific results are shown in Table 3 below.

Item Example 2 Example 3 Softness 2.4 2.6 Moisturizing effect 2.4 2.7

* 1 point: no change / 2 points: good / 3 points: very good

Referring to Tables 2 and 3, it was found that Examples 2 and 3 were excellent in alleviating or healing skin disease symptoms, and further improved skin condition from a cosmetic point of view.

The atopic dermatological compositions of Examples 2 and 3 had almost the same healing effect against skin diseases, but in terms of softness and moisturizing effect, the atopic dermatological compositions of Example 3 were relatively more in comparison with those of Example 2 Found to be excellent.

The composition for atopic dermatitis according to the present invention is composed mainly of natural products and has almost no chemical side effects, and is very excellent in alleviating or healing skin disease symptoms.

In addition, it has a very good performance in improving the condition of the skin, it is expected to be able to improve the rough skin and dry skin conditions when applied to a specific part of the body well formed keratin.

Although described with reference to the embodiments above, those skilled in the art will understand that the present invention can be variously modified and changed without departing from the spirit and scope of the invention as set forth in the claims below. Could be.

Claims (4)

Horse oil 80-98 wt%; 0.5 to 20% by weight of white powder essential oils; Lactic acid bacteria ferment 0.5-1.2% by weight; 0.01 to 0.02 weight percent of lactic acid bacteria; Octyldodecanol 0.5-0.9 wt%; And Stearyl glycyrrhetinate containing 0.04 to 0.06% by weight of atopic dermatitis composition. The method of claim 1, wherein the lactic acid bacteria fermentation is mugwort, mushroom, spinach, olive, bay leaf, kelp, seaweed, plantain, effervescent, agaricus, fig, tangerine, orange, mulberry fruit, vine, blueberry, and plum Atopic dermatitis composition comprising a fermented product of at least one plant selected from the group consisting of lactic acid bacteria. The composition for atopy skin according to claim 2, wherein the lactic acid bacteria fermented product is fermented by at least two or more complex lactic acid bacteria. The composition for atopy skin according to claim 1, wherein the composition for atopic dermatitis further comprises 0.5 to 1.0% by weight of at least one hot water extract selected from the group consisting of aloe hot water extract and Echocho hot water extract.