KR20150023132A - Composit for improving atopic dermatitis - Google Patents

Abstract

The present invention relates to a composition for atopic dermatitis, which can protect and prevent atopic dermatitis, and alleviates symptoms of atopic dermatitis. According to the present invention, the composition for atopic dermatitis comprises 80 to 98 wt% of horse oil, 0.5 to 20 wt% of cypress essential oil, 0.5 to 1.2 wt% of a lactic-acid ferment, 0.01 to 0.02 wt% of lactic acid bacteria, 0.5 to 0.9 wt% of octyldodecanol, and 0.04 to 0.06 wt% of stearyl glycyrrhetinate.

Description

COMPOSITE FOR IMPROVING ATOPIC DERMATITIS [0001]

The present invention relates to a composition for atopic dermatitis, and more particularly, to a composition for atopic dermatitis, which is capable of eliminating or alleviating each step of skin dryness, itching, inflammation, microbial infection and the like which are main clinical features of atopic dermatitis ≪ / RTI >

Atopic dermatitis is a recurrent chronic dermatitis that has a severe sense of well-being. Its cause has not yet been clearly identified, but it is estimated that 10 to 20% of the world's population suffer from this dermatitis. In addition, the prevalence rate of atopic dermatitis has been rising continuously in recent decades due to the increase of causative substances of air-mediated allergy caused by environmental pollution and the condition for forming dry skin, and the prevalence rate of atopic dermatitis The number is growing.

The term atopy has a preliminary meaning of clinical hypersensitivity or allergy, which means 'strange' or 'inappropriate' in the etymology. When a skin reaction test is conducted on protein antigens such as house dust mites, ticks, animal hair, pollen, food and the like, which are frequently encountered in the surrounding environment, a person having atopic eczema is very likely to develop an urticaria reaction to many antigens. Anaphylactic shock, urticaria and angioedema, wheezing and dyspnea, nasal obstruction, runny nose, sneezing, conjunctival hyperemia and edema, vomiting, diarrhea, abdominal pain, etc. within minutes or hours Immediate type reactions occur well in the skin, respiratory tract, eyes and intestinal mucosa, and these abnormal and inappropriate responses are family-specific.

Clinically, atopic dermatitis is characterized by relatively characteristic skin lesions and distribution patterns according to the age of the patient, which can be divided into three periods: early childhood, childhood, adolescence and adulthood. In infancy from 2 months to 3 months to 2 years of age when atopic dermatitis starts, symptoms of atopic dermatitis appear as lesions that are red, moist, greasy, crusty, etc. on the head, face, .

In the past, atopic dermatitis was thought to be a kind of allergies. However, as non-allergic considerations expand, they are approaching the causes and solutions of eczema reactions. In the process of examining the various physiological functions of the patient, the patient exhibits abnormalities such as decreased sweating, decreased sebum secretion, abnormal skin vascular response, dry skin, etc. In view of nonallergic Drying The new view suggests that skin has the most important meaning as a condition of atopic dermatitis.

When the dry skin is formed, the protective function of the skin surface is lost, and it is not only easy to invade the skin of the dermatologic material or the allergen from the outside but also cause the skin to reject the penetration. Keratinocytes, which constitute the vast majority of surface components, are activated by cells such as Langerhans and melanocytes, which cause inflammation by cytokines produced and released by these cells. The cytokine acts to attract inflammatory cells, and particularly stimulates constitutive cells of the skin to cause an inflammatory reaction mainly in the upper layer of the skin, and forms an eczema reaction, which is called non-allergic skin disease.

The atopic nonbacterium as described above has a high risk of recurrence and is usually a disease requiring special skin care.

Various types of skin compositions have conventionally been developed for this purpose. However, not only is the chemical substance mainly composed of the major components, but also there is a limit to effectively alleviate the atopic dermatitis. In addition, although atopic dermatological compositions using various natural products have been developed, there are still incomplete effects and skin applications.

The present invention provides a composition for atopic skin that protects and prevents atopic skin and alleviates the symptoms of atopic dermatitis, taking into account incompleteness of the conventional atopic dermatitis-related composition as described above.

The composition for atopic skin according to the present invention comprises 80 to 98% by weight of horse oil, 0.5 to 20% by weight of a whitening essential oil, 0.5 to 1.2% by weight of fermented lactic acid bacteria, 0.01 to 0.02% by weight of lactic acid bacterium, octyldodecanol, 0.5 to 0.9% by weight, and 0.04 to 0.06% by weight of stearyl glycyrrhetinate.

Wherein the lactic acid bacteria fermented product is at least one plant selected from the group consisting of wormwood, mushroom, spinach, olive, laurel leaf, kelp, seaweed, plantain, obtusa, agaricus, fig, citrus, orange, mulberry, Of the fermented product by the lactic acid bacteria.

The fermented lactic acid bacteria may be fermented by at least two kinds of lactic acid bacterial complexes.

The composition for atopic skin may further comprise 0.5 to 1.0% by weight of at least one hot-water extract solution selected from the group consisting of aloe hot-water extract and hot-water extract.

The composition for atopic dermatoses as described above can act on acne, dry skin and scratched skin as well as atopic dermatitis, thereby alleviating side effects due to each symptom. Furthermore, by regularly using the product regularly, it is possible not only to prevent the above-mentioned symptoms, but also to provide an excellent moisturizing effect on the user's skin.

The composition for atopic skin according to the present invention is substantially free of chemical side effects because the main component is made of natural materials, and the skin disease symptom is alleviated or the healing effect is excellent.

It is also expected to be able to improve rough skin and dry skin conditions when applied to body-specific areas where keratin is well formed, as it has very good performance in improving the condition of the skin.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the appended claims. It will be possible.

Hereinafter, the present invention will be described in detail.

The composition for atopic skin according to one aspect of the present invention comprises a natural oil component and a fermented product of lactic acid bacteria.

The composition for atopic dermatitis includes horse oil as the natural oil component. The above-mentioned horse oil is an animal oil and contains an excessive amount of unsaturated fatty acids besides saturated fatty acids. Especially, unsaturated fatty acids contain more than 60% of alpha-linolenic acid and linolenic acid. In addition, the hemp oil has very similar chemical properties to human fatty acids, and thus has excellent affinity and moisturizing power.

If the content of the hair follicle is less than 80% by weight, the skin penetration performance of the composition for atopic skin tends to deteriorate.

In addition, if the content of the main component is more than 98% by weight, the activity of the other components is significantly lowered.

Therefore, the content of the hemp oil is 80 to 98% by weight, more preferably 96 to 98% by weight.

The hemp oil can prevent secondary bacterial infection through the skin by regulating cell activity and regeneration of the skin and forming an oil film on the cells.

In addition, the composition for atopic skin includes, as a natural oil component, a whitening essential oil.

The whitening essential oil is volatile oil extracted from a hinoki tree originating in Taiwan and Japan. The hinoki tree is allowed to aerate high-temperature and high-pressure water vapor for a long time and extract only essential oil components by fractional distillation. The whitening essential oil contains 2% or more of hinoki chol. The hinochiol has high antimicrobial effect which can inhibit the growth of various bacteria such as Staphylococcus aureus and Escherichia coli.

If the content of the white essential oil is less than 0.5% by weight, the antibacterial effect is insufficient. On the other hand, if the content of the white curd essential oil exceeds 20% by weight, the activity of the fermented lactic acid bacteria tends to be weakened.

Therefore, the content of the above-mentioned whitening essential oil is 0.5 to 20% by weight, preferably 0.5 to 2% by weight.

The above-mentioned whitening essential oil has excellent sterilizing power and antibacterial power, and it can alleviate itching and scars of the skin.

The lactic acid bacteria fermented product is a product obtained by fermenting vegetable materials such as vegetables or fruits with lactic acid bacteria. Examples of the plant used for producing the fermentation product include mugwort, mushroom (pine nut, oyster), spinach, olive, laurel leaf, kelp, seaweed, plantain, mulberry, agaricus, fig, citrus, orange, mulberry, Berry, and plum. The plants may be used singly or in combination of two or more.

Examples of the lactic acid bacteria that can be used for producing the fermented lactic acid bacteria include Lactobacillus, Streptococcus, Pediococcus, Leuconostoc and the like. The lactic acid bacteria are morphologically divided into lactic acid bacterium (Lactobacillus sp.) And lactic acid bacterium (Streptococcus sp., Streptococcus sp., Pediococcus sp., And Lukonostok sp.). Physiologically, Yeast fermenting bacteria that produce yeast, and heteroblotting bacteria that produce by-products (alcohol, carbon dioxide, etc.) in addition to lactic acid.

The lactic acid bacteria fermented according to the present invention is preferably fermented into the heterozygous bacteria.

In the present invention, the content of the fermented lactic acid bacteria is preferably 0.5% by weight to 1.2% by weight. The content of the fermented lactic acid bacteria may vary depending on the kind of the lactic acid bacteria.

The composition for atopic skin according to the present invention comprises lactic acid bacteria separately from lactic acid bacteria in the production of fermented lactic acid bacteria. The added lactic acid bacteria may be different from the lactic acid bacteria for producing the fermented lactic acid bacteria. The lactic acid bacteria may be used alone or in combination of two or more different lactic acid bacteria.

The lactic acid bacteria fermentation is preferably performed by a conventional fermentation method, and it is preferable to use a fermented product aged for at least one year. The fermentation method is as follows.

That is, in order to obtain the fermented lactic acid bacteria, various materials such as mugwort, mushroom, fig, and blueberry are mixed and finely sliced, placed in a reactor in a fermenter of a water bath, and then stirred. While maintaining the temperature inside the fermenter at 20 to 45, black (sulfur) sugar is added to the reactor and then stirred again. Thereafter, the lactic acid bacteria strain is inoculated to the fermentation target of the lactic acid bacteria in the reactor, and is allowed to engraft for about one week. After a certain period of time, it is transferred to a porous container according to a conventional fermentation method, and then the fermentation product is extracted at a rate of one year, three years and five years. Alternatively, fermentation can be carried out by using a constant temperature fermenter.

The extraction time is the same as the traditional method.

In addition, the composition for atopic skin includes 0.5 to 0.9% by weight of octyldodecanol, and 0.04 to 0.06% by weight of stearyl glycyrrhetinate.

The composition for atopic skin may further comprise a hot-water extract solution of a functional plant. Examples of the hot water extract liquid include aloe, sorghum and the like. The functional plants may be used alone or in combination of two or more.

The hot-water extract is preferably contained in an amount of 0.5 to 1.0 wt%.

Although not described herein, the composition for atopic skin according to the present invention may further include natural ingredients or chemical ingredients capable of performing a specific function.

Hereinafter, the present invention will be described in detail with reference to examples. However, the technical idea of the present invention is not limited by the following examples.

Example

[Example 1]

Production of fermented lactic acid bacteria

For quick implementation, the general fermentation method is used instead of the traditional method in this embodiment.

Mugwort, mushroom, spinach, olive, laurel leaf, kelp, seaweed, plantain, obtusa, agaricus, fig, citrus, orange, mulberry, mulberry, blueberry and plum were used as samples for fermentation.

Each of the above samples was dried and pulverized. Each of the crushed samples was immersed in distilled water for about 4 hours and sterilized in a sterilization pot at 110 ° C. Lactobacillus acidophilus lactobacillus acidophilus and lactobacillus bularicus were mixed with each of the sterilized samples, and the mixture was inoculated 1% and cultured for about one day. Each of the fermentations cultured during the day was lyophilized.

The lyophilized fermentations were centrifuged and the centrifuged fractions were concentrated.

[Example 2]

Preparation of composition for atopic skin (1)

A composition for atopic skin was prepared using the concentrated fermented product (wormwood, fig) prepared in Example 1 above.

First, in order to prepare the composition for atopic dermatitis, fermented lactic acid bacteria, lactic acid bacteria, octyldodecanol, and stearyl glycyrrhetinate were each added to Ma yu and sufficiently stirred. To the agitated mixture was added a whiskey essential oil (Aomori Hiba) and further mixed and stirred.

The final product, a composition for atopic dermatitis, was a cream-type composition having a slight viscosity.

The composition of the composition for atopic skin prepared in this Example is shown in Table 1 below.

[Example 3]

Preparation of compositions for atopic dermatitis (2)

The composition for atopic skin according to this example is the same as the composition for atopic composition of Example 2 except that it further comprises a hot-water extract.

In this example, hot water extract of aloe and rhizome was further added to Maou.

The hot-water extract was prepared by cutting the aloe and herringbone into fractions of a predetermined size, and then subjecting to hot-water extraction using water at 100 ° C.

The composition of the composition for atopic skin prepared in this Example is shown in Table 1 below.

ingredient Content (% by weight) Example 2 Example 3 Mayu 80 80 Whitening oil 18.23 17.23 Fermented product of lactic acid bacteria Mugwort fermented water 0.5 0.5 Fig fermentation product 0.5 0.5 Lactobacillus Lactobacillus acidophilus 0.01 0.01 Lactobacillus bulgaricus 0.01 0.01 Octyldodecanol 0.7 0.7 Stearyl glycyrrhetinate 0.05 0.05 Hot Water Extract (Aloe / Persimmon) 1.0

[Example 4]

Panel Test (1)

A 14-year old male (A) and a 12-year-old female (B) with acne were each given 2 hours of cleansing before going to bed for 2 weeks and then applied the composition for atopic skin prepared in Example 2 and evaluated the degree of improvement.

A 14-year old man (A) and a 12-year-old woman (B) with acne were each given 2 hours of cleansing before going to bed to apply the composition for atopic skin prepared in Example 3 and evaluate the degree of improvement.

- A 3 year old male (C) with severe atopic symptoms in both arms was given the composition for atopic skin prepared in Example 2 for 2 weeks, and the degree of improvement of symptoms was evaluated.

- A 3-year old male (C) with severe atopic symptoms in both arms was given the composition for atopic skin prepared in Example 3 for 2 weeks, and the degree of improvement of symptoms was evaluated.

- An adult female (D) having severe itching, red spot, and skin peeling due to the pharmacological treatment of both hands was applied with the composition for atopic skin prepared in Example 2 for 1 week, and the degree of improvement of symptoms was evaluated.

- An adult female (D) with severe itching, red spot, and skin peeling due to the pharmacological treatment of both hands was applied with the composition for atopic skin prepared in Example 3 for 1 week and the degree of improvement of symptoms was evaluated.

- An adult male (E) with peeling of the keratin on the leg and waist side and severe itching was applied the composition for atopic skin prepared in Example 2 for 1 week and the improvement degree of the symptom was evaluated.

- An adult male (E) with peeled keratin on the legs and waist side and severe itching was applied with the composition for atopic skin prepared in Example 3 for 1 week, and the degree of improvement of symptoms was evaluated.

The evaluation results are shown in Table 2 below.

object Example 1 Example 2 A 4 4 B 4 4 C 5 5 D 4 5 E 3 4

* 5: Almost cured / 4: Very cured / 3: Good / 2: No change / 1: Bad condition

[Example 5]

Panel Test (2)

Five adults each having no specific skin disease were evaluated for skin condition (softness / moisturizing effect) of the area where the composition for atopic skin was applied (right elbow) after 2 weeks of correcting the skin composition for atopic skin of Example 2 Respectively.

Likewise, each of the five adult males and females was given the same composition for atopic dermatitis of Example 3 for 2 weeks, and after two weeks, the skin condition (softness / moisturizing effect) of the area where the composition for atopic skin was applied (left elbow) was evaluated .

Results were expressed as mean values of 10 persons. Specific results are shown in Table 3 below.

Item Example 2 Example 3 Softness 2.4 2.6 Moisturizing effect 2.4 2.7

* 1 point: No change / 2 points: Good / 3 points: Very good

Referring to Tables 2 and 3, it was found that Examples 2 and 3 were excellent in relieving or curing skin disease symptoms, and further improving the skin condition from a cosmetic point of view.

The compositions for atopic dermatoses of Examples 2 and 3 showed almost similar curing effects to skin diseases. However, in terms of softness and moisturizing effect, the compositions for atopic dermatitis of Example 3 were relatively more .

Claims (4)

Horse oil 80 to 98% by weight;
0.5 to 20% by weight of a white essential oil;
0.5 to 1.2% by weight of fermented lactic acid bacteria;
0.01 to 0.02% by weight of lactic acid bacterium;
0.5 to 0.9% by weight of octyldodecanol; And
0.04 to 0.06% by weight of stearyl glycyrrhetinate. The fermented product of lactic acid bacteria according to claim 1, wherein the fermented lactic acid bacteria is selected from the group consisting of wormwood, mushroom, spinach, olive, laurel leaf, kelp, seaweed, plantain, obtusa, agaricus, fig, tangerine, orange, mulberry, And at least one plant fermented by a lactic acid bacterium selected from the group consisting of: [Claim 3] The composition for atopic skin according to claim 2, wherein the fermented lactic acid bacteria is fermented by at least two or more kinds of lactic acid bacteria. The composition for atopic skin according to claim 1, wherein the composition for atopic skin further comprises 0.5 to 1.0% by weight of at least one hot-water extract solution selected from the group consisting of aloe hot-water extract and hot-water extract.